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2. The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure.

Author

Horiuchi, Y, Wettersten, Nicholas, Vanveldhuisen, Dirk, Mueller, Christian, Nowak, Richard, Hogan, Christopher, Kontos, Michael, Cannon, Chad, Birkhahn, Robert, Vilke, Gary, Mahon, Niall, Nuñez, Julio, Briguori, Carlo, Duff, Stephen, Murray, Patrick, and Maisel, Alan

Subjects
acute heart failure, biomarker, body mass index, cardiac troponin, natriuretic peptide, Humans, Lipocalin-2, Heart Failure, Body Mass Index, Galectin 3, Biomarkers, Prognosis, Obesity, Natriuretic Peptide, Brain
Abstract

BACKGROUND: Body mass index (BMI) is a known confounder for natriuretic peptides, but its influence on other biomarkers is less well described. We investigated whether BMI interacts with biomarkers association with prognosis in patients with acute heart failure (AHF). METHODS AND RESULTS: B-type natriuretic peptide (BNP), high-sensitivity cardiac troponin I (hs-cTnI), galectin-3, serum neutrophil gelatinase-associated lipocalin (sNGAL), and urine NGAL were measured serially in patients with AHF during hospitalization in the AKINESIS (Acute Kidney Injury Neutrophil gelatinase-associated lipocalin Evaluation of Symptomatic Heart Failure) study. Cox regression analysis was used to determine the association of biomarkers and their interaction with BMI for 30-day, 90-day and 1-year composite outcomes of death or HF readmission. Among 866 patients, 21.2%, 29.7% and 46.8% had normal (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) or obese (≥ 30 kg/m2) BMIs on admission, respectively. Admission values of BNP and hs-cTnI were negatively associated with BMI, whereas galectin-3 and sNGAL were positively associated with BMI. Admission BNP and hs-cTnI levels were associated with the composite outcome within 30 days, 90 days and 1 year. Only BNP had a significant interaction with BMI. When BNP was analyzed by BMI category, its association with the composite outcome attenuated at higher BMIs and was no longer significant in obese individuals. Findings were similar when evaluated by the last-measured biomarkers and BMIs. CONCLUSIONS: In patients with AHF, only BNP had a significant interaction with BMI for the outcomes, with its association attenuating as BMI increased; hs-cTnI was prognostic, regardless of BMI.

Published
2023

3. Galectin-3, Acute Kidney Injury and Myocardial Damage in Patients With Acute Heart Failure.

Author

Horiuchi, Y, Wettersten, Nicholas, VAN Veldhuisen, Dirk, Mueller, Christian, Filippatos, Gerasimos, Nowak, Richard, Hogan, Christopher, Kontos, Michael, Cannon, Chad, Müeller, Gerhard, Birkhahn, Robert, Taub, Pam, Vilke, Gary, McDonald, Kenneth, Mahon, Niall, Nuñez, Julio, Briguori, Carlo, Passino, Claudio, Duff, Stephen, Maisel, Alan, and Murray, Patrick

Subjects
acute heart failure, acute kidney injury, galectin-3, myocardial injury, prognosis, renal tubular damage, Humans, Acute Disease, Acute Kidney Injury, Biomarkers, Cardiomyopathies, Galectin 3, Heart Failure, Kidney, Lipocalin-2, Natriuretic Peptide, Brain, Prognosis, Retrospective Studies, Troponin I
Abstract

BACKGROUND: Galectin-3, a biomarker of inflammation and fibrosis, can be associated with renal and myocardial damage and dysfunction in patients with acute heart failure (AHF). METHODS AND RESULTS: We retrospectively analyzed 790 patients with AHF who were enrolled in the AKINESIS study. During hospitalization, patients with galectin-3 elevation (> 25.9 ng/mL) on admission more commonly had acute kidney injury (assessed by KDIGO criteria), renal tubular damage (peak urine neutrophil gelatinase-associated lipocalin [uNGAL] > 150 ng/dL) and myocardial injury (≥ 20% increase in the peak high-sensitivity cardiac troponin I [hs-cTnI] values compared to admission). They less commonly had ≥ 30% reduction in B-type natriuretic peptide from admission to last measured value. In multivariable linear regression analysis, galectin-3 was negatively associated with estimated glomerular filtration rate and positively associated with uNGAL and hs-cTnI. Higher galectin-3 was associated with renal replacement therapy, inotrope use and mortality during hospitalization. In univariable Cox regression analysis, higher galectin-3 was associated with increased risk for the composite of death or rehospitalization due to HF and death alone at 1 year. After multivariable adjustment, higher galectin-3 levels were associated only with death. CONCLUSIONS: In patients with AHF, higher galectin-3 values were associated with renal dysfunction, renal tubular damage and myocardial injury, and they predicted worse outcomes.

Published
2023

4. Implications of worsening renal function before hospitalization for acute heart failure

Author

Wettersten, Nicholas, Duff, Stephen, Horiuchi, Yu, Veldhuisen, Dirk J, Mueller, Christian, Filippatos, Gerasimos, Nowak, Richard, Hogan, Christopher, Kontos, Michael C, Cannon, Chad M, Müeller, Gerhard A, Birkhahn, Robert, Taub, Pam, Vilke, Gary M, McDonald, Kenneth, Mahon, Niall, Nuñez, Julio, Briguori, Carlo, Passino, Claudio, Maisel, Alan, Murray, Patrick T, and Ix, Joachim H

Subjects
Kidney Disease, Heart Disease, Clinical Research, Cardiovascular, Patient Safety, Renal and urogenital, Humans, Kidney, Creatinine, Acute Disease, Biomarkers, Heart Failure, Hospitalization, Acute heart failure, Acute kidney injury, Cardiorenal syndrome, Cardiorespiratory Medicine and Haematology
Abstract

AimsKidney function changes dynamically during AHF treatment, but risk factors for and consequences of worsening renal function (WRF) at hospital admission are uncertain. We aimed to determine the significance of WRF at admission for acute heart failure (AHF).Methods and resultsWe evaluated a subgroup of 406 patients from The Acute Kidney Injury Neutrophil gelatinase-associated lipocalin Evaluation of Symptomatic heart failure Study (AKINESIS) who had serum creatinine measurements available within 3 months before and at the time of admission. Admission WRF was primarily defined as a 0.3 mg/dL or 50% creatinine increase from preadmission. Alternative definitions evaluated were a ≥0.5 mg/dL creatinine increase, ≥25% glomerular filtration rate decrease, and an overall change in creatinine. Predictors of admission WRF were evaluated. Outcomes evaluated were length of hospitalization, a composite of adverse in-hospital events, and the composite of death or HF readmission at 30, 90, and 365 days. Biomarkers' prognostic ability for these outcomes were evaluated in patients with admission WRF. One-hundred six patients (26%) had admission WRF. These patients had features of more severe AHF with lower blood pressure, higher BUN, and lower serum sodium concentrations at admission. Higher BNP (odds ratio [OR] per doubling 1.16-1.28, 95% confidence interval [CI] 1.00-1.55) and lower diastolic blood pressure (OR 0.97-0.98, 95% CI 0.96-0.99) were associated with a higher odds for the three definitions of admission WRF. The primary WRF definition was not associated with a longer hospitalization, but alternative WRF definitions were (1.3 to 1.6 days longer, 95% CI 1.0-2.2). WRF across definitions was not associated with a higher odds of adverse in-hospital events or a higher risk of death or HF readmission. In the subset of patients with WRF, biomarkers were not prognostic for any outcome.ConclusionsAdmission WRF is common in AHF patients and is associated with an increased length of hospitalization, but not adverse in-hospital events, death, or HF readmission. Among those with admission WRF, biomarkers did not risk stratify for adverse events.

Published
2023

5. Prediction of left ventricular thrombus after myocardial infarction: a cardiac magnetic resonance-based prospective registry

Author

Bertolin-Boronat, Carlos, Marcos-Garcés, Víctor, Merenciano-González, Hector, Perez, Nerea, Pérez del Villar, Candelas, Gavara, Jose, Lopez-Lereu, Maria P., Monmeneu, Jose V., Herrera Flores, Cristian, Domenech-Ximenos, Blanca, López-Fornás, Francisco Jesús, Rios-Navarro, Cesar, de Dios, Elena, Moratal, David, Ortiz-Pérez, Jose T., Bayes-Genis, Antoni, Rodríguez-Palomares, Jose F, Nuñez, Julio, Sánchez, Pedro L., Sanchis, Juan, and Bodi, Vicente

Published
2025
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10. Combining loop with thiazide diuretics in patients discharged home after a heart failure decompensation: Association with 30-day outcomes

Author

Fuentes, Marta, Davila, Aitor, del Amo, Sonia, Alonso, Héctor, Pérez-Llantada, Enrique, Martín-Sánchez, Francisco Javier, Miró, Òscar, Gil, Víctor, Escoda, Rosa, Sánchez, Carolina, Repullo, Daniel, Masso, Marta, Millán, Javier, Serrano, Leticia, Pavón, José, González, Nayra Cabrera, Rodríguez, Rafael Calvo, Reyes, Juan Antonio Vega, López-Grima, María Luisa, Valero, Amparo, Juan, María Ángeles, Aguirre, Alfons, Masó, Silvia Mínguez, Alonso, María Isabel, Mecina, Ana Belén, Tost, Josep, Ramón, Susana Sánchez, Rodríguez, Virginia Carbajosa, Piñera, Pascual, Nicolás, José Andrés Sánchez, Aragüés, Paula Lázaro, Garate, Raquel Torres, Rodríguez, Esther Álvarez, Arias, Pilar Paz, Alquézar-Arbé, Aitor, Herrera, Sergio, Carrete, Carlos José Romero, Jacob, Javier, Roset, Alex, Cabello, Irene, Haro, Antonio, Richard, Fernando, Fernández, Elisa, Diez, María Pilar López, Puente, Pablo Herrero, Álvarez, Joaquín Vázquez, García, Belén Prieto, Fernández, Alejandra Fernández, Ramos, Belén Álvarez, Miranda, Natalia Fernández, Llorens, Pere, Espinosa, Begoña, Jara, Gema, Felipe, Alba, Andueza, Juan Antonio, Romero, Rodolfo, López, Mariella Luengo, Domínguez, Gema, Ruíz, Martín, Arriaga, Beatriz Amores, Bergua, Beatriz Sierra, Mojarro, Enrique Martín, Jiménez, Lidia Cuevas, Bécquer, Lisette Travería, Burillo, Guillermo, García, Lluís Llauger, Urbano, Carmen Agüera, de los Ángeles, María, de la Torre, González, Jiménez, Carmen Esmeralda Romero, Ferrer, Ester Soy, Múñoz, María Adroher, Garrido, José Manuel, Lucas-Imbernón, Francisco Javier, Gaya, Rut, Bibiano, Carlos, Mir, María, Rodríguez, Beatriz, Martín, Monika Vicente, Adrada, Esther Rodríguez, Domingo, Eva, Carvajal, Marianela Guzmán, Fortuny, María José, García, Yelenis Gómez, de las Nieves Segura Coronill, Verónica, Esquivias, Marco Antonio, García, Rocío Moyano, Rodríguez, Pablo, Noceda, José, Blasco, Santiago Harris, Romero, Marta, Lorenzo, Miguel, Núñez, Gonzalo, de la Espriella, Rafael, Villar, Sandra, Santas, Enrique, Miñana, Gema, Bodí, Vicent, Sanchis, Juan, Núñez, Julio, Bautista, Prado Salamanca, Hueso, Rocío Ruiz, Domingo, Soraya, Núñez, Mª Victoria, Olmedo, Jesús, Vázquez, Carmen, López, Juan Bosco, Peinado, Alejandro, Montes, Juan Antonio, Díez-Manglano, Jesús, Rodés, Pablo Martínez, Garcés, Vanesa, Rubio, Jorge, Rodríguez, José M Fernández, Curto, Adrián Argüelles, Murphy, Orla Torrallardona, Manso, Meritxell Gavà, Martel, Alicia Conde, García, José Mª, González, Sonia, Dávila, Melitón F, Hernández, Rubén, Gudiño, Diego José, Mendoza, Humberto, Carrera, Margarita, Trullàs, Joan Carles, Epelde, Francisco, Biosca, Anna Sánchez, Becerra, Raquel, Gil, Mercè, Massi, Paulina Ivanova, Chivite, David, Formiga, Francesc, Núñez, Raquel, Pacho, Cristina, Contra, Anna, Ceresuela, Luis, Morales, José Luís, Pla, Xavi, López, Gabriel, Blázquez, Julio, Reboiro, Manuel Lorenzo López, Castro, José López, Asenjo, María, de Peralta, Paula, Llàcer, Pau, Manzano, Luis, Ortega, Raúl Antonio Ruiz, Vázquez, Miguel Ángel, Soler, Llanos, Mesado, Daniel, Casado, Jesús, Abad, Daniel, Ballesta, Ana Isabel Peláez, Rodríguez, Elena Morcillo, Lopez-Ayala, Pedro, Llauger, Lluís, Mollar, Anna, Garcés-Horna, Vanesa, Martínez-Nadal, Gemma, and Mueller, Christian

Published
2024
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11. The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases

Author

Genovese, Federica, Bager, Cecilie, Frederiksen, Peder, Vazquez, Dario, Sand, Jannie Marie Bülow, Jenkins, R Gisli, Maher, Toby M., Stewart, Iain D., Molyneaux, Philip L., Fahy, William A, Wain, Louise V., Vestbo, Jørgen, Nanthakumar, Carmel, Shaker, Saher Burhan, Hoyer, Nils, Leeming, Diana Julie, George, Jacob, Trebicka, Jonel, Rasmussen, Daniel Guldager Kring, Hansen, Michael K., Cockwell, Paul, Kremer, Daan, Bakker, Stephan JL, Selby, Nicholas M, Reese-Petersen, Alexander Lynge, González, Arantxa, Núñez, Julio, Rossing, Peter, Nissen, Neel I., Boisen, Mogens Karsbøl, Chen, Inna M., Zhao, Lei, Karsdal, Morten A., and Schuppan, Detlef

Published
2024
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13. Consensus on the approach to hydrosaline overload in acute heart failure. SEMI/SEC/S.E.N. recommendations

Author

Llàcer, Pau, Romero, Gregorio, Trullàs, Joan Carles, de la Espriella, Rafael, Cobo, Marta, Quiroga, Borja, Casado, Jesús, Slon-Roblero, María F., Morales-Rull, José Luis, Morgado, José Ignacio, Ortiz, Alberto, Formiga, Francesc, Melendo-Viu, María, de Sequera, Patricia, Recio, Alejandro, Díez, Javier, Manzano, Luis, and Núñez, Julio

Published
2024
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14. Consenso sobre el abordaje de la sobrecarga hidrosalina en insuficiencia cardiaca aguda. Recomendaciones SEMI/SEC/S.E.N.

Author

Llàcer, Pau, Romero, Gregorio, Trullàs, Joan Carles, de la Espriella, Rafael, Cobo, Marta, Quiroga, Borja, Casado, Jesús, Slon-Roblero, María F., Morales-Rull, José Luis, Morgado, José Ignacio, Ortiz, Alberto, Formiga, Francesc, Melendo-Viu, María, de Sequera, Patricia, Recio, Alejandro, Díez, Javier, Manzano, Luis, and Núñez, Julio

Published
2024
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15. Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials

Author

Butler, Javed, Shah, Sanjiv J, Petrie, Mark C, Borlaug, Barry A, Abildstrøm, Steen Z, Davies, Melanie J, Hovingh, G Kees, Kitzman, Dalane W, Møller, Daniél Vega, Verma, Subodh, Einfeldt, Mette Nygaard, Lindegaard, Marie L, Rasmussen, Søren, Abhayaratna, Walter, Ahmed, Fozia Z, Ben-Gal, Tuvia, Chopra, Vijay, Ezekowitz, Justin A, Fu, Michael, Ito, Hiroshi, Lelonek, Małgorzata, Melenovský, Vojtěch, Merkely, Bela, Núñez, Julio, Perna, Eduardo, Schou, Morten, Senni, Michele, Sharma, Kavita, van der Meer, Peter, Von Lewinski, Dirk, Wolf, Dennis, and Kosiborod, Mikhail N

Published
2024
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16. Comparing indications, complexity and outcomes of laparoscopic liver resection between centers with and without a liver transplant program: a French nationwide study

Author

Cauchy, Francois, Nomi, Takeo, Oudafal, Nassima, Gayet, Brice, Kawai, Takayuki, Komatsu, Shohei, Okumura, Shinya, Petrucciani, Nicolo, Bucur, Petru, Trechot, Boris, Nunez, Julio, Tedeschi, Michele, Allard, Marc-Antoine, Golse, Nicolas, Ciacio, Oriana, Pittau, Gabriella, Cunha, Antonio S., Adam, Rene, Laurent, Christophe, Leourier, Pauline, Rebibo, Lionel, Ferre, Lorenzo, Souche, Francois-Regis, Chauvat, John, Jehaes, Francois, Mohkam, Kayvan, Hor, Thevy, Paye, Francois, Balladur, Pierre, Suc, Bertrand, Millet, Guillaume, Amrani, Mehdi El, Ratajczak, Celine, Lecolle, Katia, Pruvot, Francois-Rene, Kianmanesh, Ali-Reza, Codjia, Tatiana, Schwarz, Lilian, Girard, Edouard, Abba, Julio, Letoublon, Christian, Bouras, Ahmed F., Carmelo, Antoine, VanBrugghe, Charles, Cherkaoui, Zineb, Unterteiner, Xavier, Pessaux, Patrick, Memeo, Riccardo, Lhermite, Emilie, Bougard, Marie, Barbieux, Julien, Marchese, Ugo, Ewald, Jacques, Turini, Olivier, Thobie, Alexandre, Menahem, Benjamin, Mulliri, Andrea, Lubrano, Jean, Zemour, Johanna, Fagot, Herve, Passot, Guillaume, Gregoire, Emilie, le Treut, Yves P., Patrice, David, Laroche, Sophie, Lim, Chetana, Goumard, Claire, Rayar, Michel, Cherqui, Daniel, Chiche, Laurence, Barbier, Louise, Salamé, Ephrem, Mabrut, Jean-Yves, Lesurtel, Mickael, Truant, Stéphanie, Boleslawski, Emmanuel, Muscari, Fabrice, Hobeika, Christian, Chirica, Mircea, Buc, Emmanuel, Hardwigsen, Jean, Herrero, Astrid, Navarro, Francis, Faitot, François, Bachellier, Philippe, Regimbeau, Jean-Marc, Laurent, Alexis, Fuks, David, Soubrane, Olivier, Azoulay, Daniel, Vibert, Eric, and Scatton, Olivier

Published
2024
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24. Sodium Zirconium Cyclosilicate for Management of Hyperkalemia During Spironolactone Optimization in Patients With Heart Failure

Author

Kosiborod, Mikhail N., Cherney, David Z.I., Desai, Akshay S., Testani, Jeffrey M., Verma, Subodh, Chinnakondepalli, Khaja, Dolling, David, Patel, Shachi, Dahl, Magnus, Eudicone, James M., Friberg, Lovisa, Ouwens, Mario, Antunes, Murillo O., Connelly, Kim A., Madrini, Vagner, Jr., Kuthi, Luca, Lala, Anuradha, Lorenzo, Miguel, Guimarães, Patrícia O., Marcos, Marta Cobo, Merkely, Béla, Nuñez, Julio, Squire, Iain, Václavík, Jan, Wranicz, Jerzy, and Petrie, Mark C.

Published
2024
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25. Utilidad pronóstica de la angina persistente tras revascularización percutánea en el síndrome coronario crónico con angiografía y RMC de estrés alteradas

Author

Pérez-Solé, Nerea, de Dios, Elena, Monmeneu, José V., López-Lereu, María P., Gavara, José, Ríos-Navarro, César, Marcos-Garces, Víctor, Merenciano, Héctor, Bonanad, Clara, Cánoves, Joaquim, Platero, Félix, Ventura, Andrea, Moratal, David, Bayés-Genís, Antoni, Sanz, Jorge, Jiménez-Navarro, Manuel, Martínez-Dolz, Luis, Sanchis, Juan, Núñez, Julio, and Bodí, Vicente

Published
2024
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26. Prognostic role of persistent angina after percutaneous revascularization in chronic coronary syndrome with altered angiography and stress CMR

Author

Pérez-Solé, Nerea, de Dios, Elena, Monmeneu, José V., López-Lereu, María P., Gavara, José, Ríos-Navarro, César, Marcos-Garces, Víctor, Merenciano, Héctor, Bonanad, Clara, Cánoves, Joaquim, Platero, Félix, Ventura, Andrea, Moratal, David, Bayés-Genís, Antoni, Sanz, Jorge, Jiménez-Navarro, Manuel, Martínez-Dolz, Luis, Sanchis, Juan, Núñez, Julio, and Bodí, Vicente

Published
2024
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27. Geriatric conditions and invasive management in frail patients with NSTEMI. A subgroup analysis of a randomized clinical trial

Author

Sanchis, Juan, Bueno, Héctor, García-Blas, Sergio, Gómez-Hospital, Joan A., Martí, David, Martínez-Sellés, Manuel, Domínguez-Pérez, Laura, Díez-Villanueva, Pablo, Barrabés, José A., Marín, Francisco, Villa, Adolfo, Sanmartín, Marcelo, Llibre, Cinta, Sionis, Alessandro, Carol, Antoni, Valero, Ernesto, Calvo, Elena, Morales, María José, Elízaga, Jaime, Gómez, Iván, Alfonso, Fernando, García del Blanco, Bruno, Formiga, Francesc, Núñez, Eduardo, Núñez, Julio, and Ariza-Solé, Albert

Published
2024
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29. Prevalence and clinical profile of kidney disease in patients with chronic heart failure. Insights from the Spanish cardiorenal registry

Author

Cobo Marcos, Marta, de la Espriella, Rafael, Gayán Ordás, Jara, Llàcer, Pau, Pomares, Antonia, Fort, Aleix, Ponz de Antonio, Inés, Méndez, Ana, Blázquez-Bermejo, Zorba, Caravaca Pérez, Pedro, Rubio Gracia, Jorge, Recio-Mayoral, Alejandro, Zegrí, Isabel, García Pinilla, José Manuel, Montero Hernández, Esther, Castro, Almudena, Soler, María José, Górriz, José Luis, Bascompte Claret, Ramón, Fluvià-Brugués, Paula, Manzano, Luis, and Núñez, Julio

Published
2024
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30. Condiciones geriátricas y estrategia invasiva en pacientes frágiles con IAMSEST. Análisis de subgrupos de un ensayo clínico aleatorizado

Author

Sanchis, Juan, Bueno, Héctor, García-Blas, Sergio, Gómez-Hospital, Joan A., Martí, David, Martínez-Sellés, Manuel, Domínguez-Pérez, Laura, Díez-Villanueva, Pablo, Barrabés, José A., Marín, Francisco, Villa, Adolfo, Sanmartín, Marcelo, Llibre, Cinta, Sionis, Alessandro, Carol, Antoni, Valero, Ernesto, Calvo, Elena, Morales, María José, Elízaga, Jaime, Gómez, Iván, Alfonso, Fernando, García del Blanco, Bruno, Formiga, Francesc, Núñez, Eduardo, Núñez, Julio, and Ariza-Solé, Albert

Published
2024
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32. Prevalencia y perfil clínico de la enfermedad renal en pacientes con insuficiencia cardiaca crónica. Datos del Registro cardiorrenal español

Author

Cobo Marcos, Marta, de la Espriella, Rafael, Gayán Ordás, Jara, Llàcer, Pau, Pomares, Antonia, Fort, Aleix, Ponz de Antonio, Inés, Méndez, Ana, Blázquez-Bermejo, Zorba, Caravaca Pérez, Pedro, Rubio Gracia, Jorge, Recio-Mayoral, Alejandro, Zegrí, Isabel, García Pinilla, José Manuel, Montero Hernández, Esther, Castro, Almudena, Soler, María José, Górriz, José Luis, Bascompte Claret, Ramón, Fluvià-Brugués, Paula, Manzano, Luis, and Núñez, Julio

Published
2024
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33. Decongestion discriminates risk for one-year mortality in patients with improving renal function in acute heart failure.

Author

Wettersten, Nicholas, Horiuchi, Yu, van Veldhuisen, Dirk, Ix, Joachim, Mueller, Christian, Filippatos, Gerasimos, Nowak, Richard, Hogan, Christopher, Kontos, Michael, Cannon, Chad, Müeller, Gerhard, Birkhahn, Robert, Taub, Pam, Vilke, Gary, Duff, Stephen, McDonald, Kenneth, Mahon, Niall, Nuñez, Julio, Briguori, Carlo, Passino, Claudio, Maisel, Alan, and Murray, Patrick

Subjects
Acute heart failure, B-type natriuretic peptide, Congestion, Kidney function, Prognosis, Acute Disease, Aged, Biomarkers, Heart Failure, Humans, Kidney, Male, Natriuretic Peptide, Brain, Prognosis
Abstract

AIMS: Improving renal function (IRF) is paradoxically associated with worse outcomes in acute heart failure (AHF), but outcomes may differ based on response to decongestion. We explored if the relationship of IRF with mortality in hospitalized AHF patients differs based on successful decongestion. METHODS AND RESULTS: We evaluated 760 AHF patients from AKINESIS for the relationship between IRF, change in B-type natriuretic peptide (BNP), and 1-year mortality. IRF was defined as a ≥20% increase in estimated glomerular filtration rate (eGFR) relative to admission. Adequate decongestion was defined as a ≥40% decrease in last measured BNP relative to admission. IRF occurred in 22% of patients who had a mean age of 69 years, 58% were men, 72% were white, and median admission eGFR was 49 mL/min/1.73 m2 . IRF patients had more severe heart failure reflected by lower admission eGFR, higher blood urea nitrogen, lower systolic blood pressure, lower sodium, and higher use of inotropes. IRF patients had higher 1-year mortality (25%) than non-IRF patients (15%) (P

Published
2021

45. Empagliflozin cardiovascular and renal effectiveness and safety compared to dipeptidyl peptidase-4 inhibitors across 11 countries in Europe and Asia: Results from the EMPagliflozin compaRative effectIveness and SafEty (EMPRISE) study

Author

Karasik, Avraham, Lanzinger, Stefanie, Chia-Hui Tan, Elise, Yabe, Daisuke, Kim, Dae Jung, Sheu, Wayne H-H, Melzer-Cohen, Cheli, Holl, Reinhard W., Ha, Kyoung Hwa, Khunti, Kamlesh, Zaccardi, Francesco, Subramanian, Anuradhaa, Nirantharakumar, Krishnarajah, Nyström, Thomas, Niskanen, Leo, Linnemann Jensen, Majken, Hoti, Fabian, Klement, Riho, Déruaz-Luyet, Anouk, Kyaw, Moe H., Koeneman, Lisette, Vistisen, Dorte, Carstensen, Bendix, Halvorsen, Sigrun, Langslet, Gisle, Fazeli Farsani, Soulmaz, Patorno, Elisabetta, and Núñez, Júlio

Published
2023
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