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7. Incidence patterns of childhood non-Wilms renal tumors: Comparing data of the Nationwide Registry of Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST), Greece, and the Surveillance, Epidemiology, and End Results Program (SEER), USA

Author

Moschovi, Maria, Antoniad, Kondilia, Polychronopoulou, Sofia, Papakonstantinou, Eugenia, Tragiannidis, Athanasios, Vasileiou, Eleni, Katzilakis, Nikolaos, Pelagiadis, Iordanis, Dana, Helen, Stefanaki, Kalliopi, Strantzia, Katerina, Gavra, Maria, Alexopoulou, Aikaterini, Doganis, Dimitrios, Karalexi, Maria A., Panagopoulou, Paraskevi, Bouka, Panagiota, Bouka, Evdoxia, Markozannes, Georgios, Ntzani, Evangelia E., Steliarova-Foucher, Eva, and Petridou, Eleni Th.

Published
2022
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8. The Effect of Activity Tracking Apps on Physical Activity and Glycemic Control in People with Prediabetes Compared to Normoglycemic Individuals: A Pilot Study.

Author

Kalampoki, Aikaterini, Ntzani, Evangelia E., Asimakopoulos, Alexandros-Georgios I., Liberopoulos, Evangelos, Tentolouris, Nikolaos, Anastasiou, Georgia, Adamidis, Petros-Spyridonas, Kotsa, Kalliopi, and Rizos, Evangelos C.

Abstract

Introduction—Aim: Adopting a lifestyle that incorporates regular physical activity confers substantial benefits to both physical and mental health and is recommended for prediabetic individuals. The aim of this study is to investigate the impact of activity tracking apps on increasing physical activity and its effect on glycemic control in people with prediabetes. Materials and Methods: This pilot study included 37 participants, 18 in the prediabetic group and 19 in the normoglycemic group matched for age and gender (mean age 53 years, 40% males). Participants used the Google Fit app for 3 months. The number of daily steps was recorded via the app, and blood and urine tests as well as body fat measurements were conducted before and following 3 months of app use. The co-primary outcome was the change in steps, and the change in HbA1c in both groups. Secondary outcomes were the change in fasting plasma glucose (FPG) (main secondary outcome), as well as lipid parameters, body mass index, visceral fat, and kidney function indices among the two groups. Results: Both groups increased the daily step count following the app intervention, without any statistically significant difference when we compared the steps change between the two groups. We found a statistically significant difference between HbA1c levels in favor of the prediabetic compared to the normoglycemic group [mean difference (MD) 0.16, 95%CI 0.04, 0.28, p-value 0.01)], following the 3-month intervention. Additionally, there was a statistically significant difference between FPG levels in favor of the prediabetic compared to the normoglycemic group (MD 9.06, 95%CI 4.16, 13.96, p-value 0.001). Conclusions: The present study suggests that the use of activity tracking apps, combined with tailored activity goals and monthly supportive phone calls, may contribute to improved glycemic control among individuals with prediabetes. [ABSTRACT FROM AUTHOR]

Published
2025
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16. Effect of Different Dietary Patterns on Cardiometabolic Risk Factors: An Umbrella Review of Systematic Reviews and Meta-Analyses.

Author

Chatzi, Christina A., Basios, Athanasios, Markozannes, Georgios, Ntzani, Evangelia E., Tsilidis, Konstantinos K., Kazakos, Kyriakos, Agouridis, Aris P., Barkas, Fotios, Pappa, Maria, Katsiki, Niki, and Rizos, Evangelos C.

Abstract

Background/Objectives: Lifestyle interventions such as dietary changes have been proposed to control the cardiometabolic risk factors and thus prevent cardiovascular (CV) disease (CVD). We performed an umbrella review to investigate whether different dietary patterns affect CV risk in individuals with at least one cardiometabolic risk factor (hypertension, dyslipidemia, obesity, diabetes, metabolic syndrome) but not established CVD. Methods: We systematically searched the PubMed and Scopus databases (up to August 2024) for the systematic reviews and meta-analyses of randomized controlled trials (RCTs). Articles should be written in English and refer to a specific dietary pattern (such as Mediterranean diet, etc.). The population studied referred to adults with at least one cardiovascular (CV) risk factor. Results: From 4512 records identified, we finally included 25 meta-analyses with a total of 329 associations. Strong evidence for a benefit was found for LCD with reductions in BW [MD: −4.79 (95% CI −5.85, −3.72) kg, p ≤ 0.001], SBP [MD: −6.38 (95% CI −7.84, −4.93) mmHg, p ≤ 0.001], TG [WMD: −5.81 (95% CI −7.96, −3.66) mg/dL, p ≤ 0.001], and fasting plasma insulin [MD: −15.35 (95% CI −19.58, −11.12) pmol/L, p ≤ 0.001], as well as for low-GI diet for the reduction of BW [SMD: −0.66 (95% CI −0.90, −0.43) kg, p ≤ 0.001]. Conclusions: Across many dietary patterns, LCD showed strong or highly suggestive evidence for a benefit on SBP, BW reduction, and lipid profile improvement. Secondarily, low-GI, DASH, and Portfolio and Nordic diets suggested beneficial effects on controlling CV risk. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Fertilizers and Human Health—A Systematic Review of the Epidemiological Evidence.

Author

Tagkas, Christos F., Rizos, Evangelos C., Markozannes, Georgios, Karalexi, Maria A., Wairegi, Lydia, and Ntzani, Evangelia E.

Subjects
ORGANIC fertilizers, SOIL fertility, FERTILIZERS, ENVIRONMENTAL exposure, HEMATOLOGIC malignancies
Abstract

Background: Fertilizers are widely used to supply nutrients to crops, thereby increasing yields and soil fertility. However, the effects of their production and application on human health through occupational, residential, and environmental exposure remain unclear. Objective: To conduct a systematic review of epidemiological studies on the association between exposure to fertilizers and health-related outcomes. Methods: We searched in PubMed, Scopus, and Web of Science for cohort, case-control, cross-sectional, and ecological studies (up to May 2024) related to exposure to fertilizers and any reported human health endpoints across all age groups, without language or geographical limitations. Data were extracted for population and study characteristics, type of fertilizer used, exposure assessment, sample size, outcome and its definition, effect estimate, and quality characteristics from the eligible studies, and they were descriptively synthesized. Results: We found 65 eligible publications, with 407 postulated associations. Forty-six publications (321 associations) assessed exposure to inorganic fertilizers, and nineteen studies (93 associations) assessed organic fertilizers. Exposure assessed was related to occupation, residence, and/or proximity. The assessed outcomes were diverse, with considerable harmonization challenges. Inorganic fertilizers have been associated with an increased risk of cancerous outcomes in a small number of studies with methodological limitations and low replication validity, while organic fertilizers have been associated with infections and diarrhea. Conclusions: The epidemiological evidence suggests possible associations between inorganic fertilizers with solid organ tumors and hematological malignancies and organic fertilizers with infections and diarrhea. However, the available evidence is limited, and heterogeneity prevails. Further research is needed to enlarge the evidence base and increase the replication validity and robustness of the results. [ABSTRACT FROM AUTHOR]

Published
2024
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21. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

Author

Evangelou, Evangelos, Kerkhof, Hanneke J, Styrkarsdottir, Unnur, Ntzani, Evangelia E, Bos, Steffan D, Esko, Tonu, Evans, Daniel S, Metrustry, Sarah, Panoutsopoulou, Kalliope, Ramos, Yolande FM, Thorleifsson, Gudmar, Tsilidis, Konstantinos K, Arden, Nigel, Aslam, Nadim, Bellamy, Nicholas, Birrell, Fraser, Blanco, Francisco J, Carr, Andrew, Chapman, Kay, Day-Williams, Aaron G, Deloukas, Panos, Doherty, Michael, Engström, Gunnar, Helgadottir, Hafdis T, Hofman, Albert, Ingvarsson, Thorvaldur, Jonsson, Helgi, Keis, Aime, Keurentjes, J Christiaan, Kloppenburg, Margreet, Lind, Penelope A, McCaskie, Andrew, Martin, Nicholas G, Milani, Lili, Montgomery, Grant W, Nelissen, Rob GHH, Nevitt, Michael C, Nilsson, Peter M, Ollier, William ER, Parimi, Neeta, Rai, Ashok, Ralston, Stuart H, Reed, Mike R, Riancho, Jose A, Rivadeneira, Fernando, Rodriguez-Fontenla, Cristina, Southam, Lorraine, Thorsteinsdottir, Unnur, Tsezou, Aspasia, Wallis, Gillian A, Wilkinson, J Mark, Gonzalez, Antonio, Lane, Nancy E, Lohmander, L Stefan, Loughlin, John, Metspalu, Andres, Uitterlinden, Andre G, Jonsdottir, Ingileif, Stefansson, Kari, Slagboom, P Eline, Zeggini, Eleftheria, Meulenbelt, Ingrid, Ioannidis, John PA, Spector, Tim D, van Meurs, Joyce BJ, Valdes, Ana M, and Consortium, arcOGEN

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Prevention, Arthritis, Human Genome, Genetics, Osteoarthritis, Aging, Pain Research, 2.1 Biological and endogenous factors, Musculoskeletal, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, HMGN Proteins, Homeodomain Proteins, Humans, Immediate-Early Proteins, Male, Nuclear Receptor Coactivator 3, Osteoarthritis, Hip, Polymorphism, Single Nucleotide, Protein Serine-Threonine Kinases, Protein-Tyrosine Kinases, Sex Factors, White People, Dyrk Kinases, arcOGEN Consortium, Epidemiology, Gene Polymorphism, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectivesOsteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects.MethodsWe performed a two-stage meta-analysis on more than 78,000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres were used for 'in silico' or 'de novo' replication. Besides the main analysis, a stratified by sex analysis was performed to detect possible sex-specific signals. Meta-analysis was performed using inverse-variance fixed effects models. A random effects approach was also used.ResultsWe accumulated 11,277 cases of radiographic and symptomatic hip OA. We prioritised eight single nucleotide polymorphism (SNPs) for follow-up in the discovery stage (4349 OA cases); five from the combined analysis, two male specific and one female specific. One locus, at 20q13, represented by rs6094710 (minor allele frequency (MAF) 4%) near the NCOA3 (nuclear receptor coactivator 3) gene, reached genome-wide significance level with p=7.9×10(-9) and OR=1.28 (95% CI 1.18 to 1.39) in the combined analysis of discovery (p=5.6×10(-8)) and follow-up studies (p=7.3×10(-4)). We showed that this gene is expressed in articular cartilage and its expression was significantly reduced in OA-affected cartilage. Moreover, two loci remained suggestive associated; rs5009270 at 7q31 (MAF 30%, p=9.9×10(-7), OR=1.10) and rs3757837 at 7p13 (MAF 6%, p=2.2×10(-6), OR=1.27 in male specific analysis).ConclusionsNovel genetic loci for hip OA were found in this meta-analysis of GWAS.

Published
2014

22. Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortium

Author

Papadimitriou, Nikos, Tsilidis, Konstantinos K, Orfanos, Philippos, Benetou, Vassiliki, Ntzani, Evangelia E, Soerjomataram, Isabelle, Künn-Nelen, Annemarie, Pettersson-Kymmer, Ulrika, Eriksson, Sture, Brenner, Hermann, Schöttker, Ben, Saum, Kai-Uwe, Holleczek, Bernd, Grodstein, Francine D, Feskanich, Diane, Orsini, Nicola, Wolk, Alicja, Bellavia, Andrea, Wilsgaard, Tom, Jørgensen, Lone, Boffetta, Paolo, Trichopoulos, Dimitrios, and Trichopoulou, Antonia

Published
2017
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25. Interventions for Substance Use Disorders in Adolescents: A Systematic Review

Author

Steele, Dale W., primary, Becker, Sara J., additional, Danko, Kristin J., additional, Balk, Ethan M., additional, Saldanha, Ian J., additional, Adam, Gaelen P., additional, Bagley, Sarah M., additional, Friedman, Catherine, additional, Spirito, Anthony, additional, Scott, Kelli, additional, Ntzani, Evangelia E., additional, Saeed, Iman, additional, Smith, Bryant, additional, Popp, Jonah, additional, and Trikalinos, Thomas A., additional

Published
2020
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33. Nutritional Status at Diagnosis as Predictor of Survival from Childhood Cancer: A Review of the Literature

Author

Karalexi, Maria A., primary, Markozannes, Georgios, additional, Tagkas, Christos F., additional, Katsimpris, Andreas, additional, Tseretopoulou, Xanthippi, additional, Tsilidis, Konstantinos K., additional, Spector, Logan G., additional, Schüz, Joachim, additional, Siahanidou, Tania, additional, Petridou, Eleni Th., additional, and Ntzani, Evangelia E., additional

Published
2022
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34. Difference on Glucose Profile From Continuous Glucose Monitoring in People With Prediabetes vs. Normoglycemic Individuals: A Matched-Pair Analysis

Author

Rizos, Evangelos C., primary, Kanellopoulou, Afroditi, additional, Filis, Panagiotis, additional, Markozannes, Georgios, additional, Chaliasos, Konstantinos, additional, Ntzani, Evangelia E., additional, Tzamouranou, Athina, additional, Tentolouris, Nikolaos, additional, and Tsilidis, Konstantinos K., additional

Published
2022
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36. Reply - Letter to the editor

Author

Markozannes, Georgios, primary, Ntzani, Evangelia E., additional, Tsiara, Stavroula, additional, Xanthos, Theodoros, additional, Patrikios, Ioannis, additional, and Rizos, Evangelos C., additional

Published
2022
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37. Incidence patterns of childhood non-Wilms renal tumors: Comparing data of the Nationwide Registry of Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST), Greece, and the Surveillance, Epidemiology, and End Results Program (SEER), USA

Author

Doganis, Dimitrios, primary, Karalexi, Maria A., additional, Panagopoulou, Paraskevi, additional, Bouka, Panagiota, additional, Bouka, Evdoxia, additional, Markozannes, Georgios, additional, Ntzani, Evangelia E., additional, Steliarova-Foucher, Eva, additional, Petridou, Eleni Th., additional, Moschovi, Maria, additional, Antoniad, Kondilia, additional, Polychronopoulou, Sofia, additional, Papakonstantinou, Eugenia, additional, Tragiannidis, Athanasios, additional, Vasileiou, Eleni, additional, Katzilakis, Nikolaos, additional, Pelagiadis, Iordanis, additional, Dana, Helen, additional, Stefanaki, Kalliopi, additional, Strantzia, Katerina, additional, Gavra, Maria, additional, and Alexopoulou, Aikaterini, additional

Published
2022
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38. sj-docx-1-dst-10.1177_19322968221123530 – Supplemental material for Difference on Glucose Profile From Continuous Glucose Monitoring in People With Prediabetes vs. Normoglycemic Individuals: A Matched-Pair Analysis

Author

Rizos, Evangelos C., Kanellopoulou, Afroditi, Filis, Panagiotis, Markozannes, Georgios, Chaliasos, Konstantinos, Ntzani, Evangelia E., Tzamouranou, Athina, Tentolouris, Nikolaos, and Tsilidis, Konstantinos K.

Subjects
111708 Health and Community Services, FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, Medicine, FOS: Health sciences, 110306 Endocrinology
Abstract

Supplemental material, sj-docx-1-dst-10.1177_19322968221123530 for Difference on Glucose Profile From Continuous Glucose Monitoring in People With Prediabetes vs. Normoglycemic Individuals: A Matched-Pair Analysis by Evangelos C. Rizos, Afroditi Kanellopoulou, Panagiotis Filis, Georgios Markozannes, Konstantinos Chaliasos, Evangelia E. Ntzani, Athina Tzamouranou, Nikolaos Tentolouris and Konstantinos K. Tsilidis in Journal of Diabetes Science and Technology

Published
2022
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39. Online supplementary file 1 - Supplemental material for Treatment With Dupilumab in Patients With Atopic Dermatitis: Systematic Review and Meta-Analysis

Author

Koskeridis, Fotios, Evangelou, Evangelos, Ntzani, Evangelia E., Kostikas, Konstantinos, and Tsabouri, Sophia

Subjects
Medicine
Abstract

Supplemental material, Online supplementary file 1, for Treatment With Dupilumab in Patients With Atopic Dermatitis: Systematic Review and Meta-Analysis by Fotios Koskeridis, Evangelos Evangelou, Evangelia E. Ntzani, Konstantinos Kostikas and Sophia Tsabouri in Journal of Cutaneous Medicine and Surgery

Published
2022
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40. Generalizability of randomized controlled trials in primary health care: Applying the PRECIS‐2 tool on published protocols.

Author

Papagiannopoulou, Evridiki, Laiou, Elpiniki, Tatsi, Chrysanthi, Dimakopoulos, Georgios, Ntzani, Evangelia E., Siamopoulos, Konstantinos, and Tatsioni, Athina

Subjects
PUBLISHING, STATISTICS, CONFIDENCE intervals, MULTIVARIATE analysis, PRIMARY health care, MEDICAL protocols, RANDOMIZED controlled trials, DESCRIPTIVE statistics, ODDS ratio
Abstract

Rationale: Pragmatic design may facilitate the generalizability of effectiveness of randomized controlled trials (RCTs) in primary health care (PHC). Aims and Objectives: The aim of this study was to investigate whether published protocols in PHC were designed pragmatically and to explore whether specific trial characteristics may be related to a pragmatic design. Methods: Using the Pragmatic Explanatory Continuum Indicator Summary‐2 (PRECIS‐2), we assessed pragmatism for 123 published RCT protocols. For each domain, we calculated the mean score with the 95% confidence interval (95% CI). Interrater reliability was assessed by weighted κ‐coefficient with 95% CI. We examined potential associations of published protocol characteristics with overall pragmatism by performing univariate and multivariate analyses. Results: We observed the highest score for primary analysis (4.66, 95% CI: 4.51, 4.82). The eligibility score was intermediate (3.16, 95% CI: 3.01, 3.32). Domains with scores towards the explanatory side included organization (2.50, 95% CI: 2.36, 2.63), flexibility of delivery (2.74, 95% CI: 2.60, 2.88) and flexibility of adherence (3.00, 95% CI: 2.83, 3.17). Interrater agreement was good (κ = 0.61; 95% CI: 0.34, 0.80; p < 0.001). Higher sample sizes were correlated to a pragmatic design (odds ratio: 6.86, 95% CI: 1.64, 28.75; p = 0.04). Conclusion: Most RCT protocols were rated as intermediate in the pragmatic‐explanatory continuum. Future research may guide all stakeholders on how best to incorporate the level of pragmatism in the interpretation of the results so that the trials are more likely to be applicable in real‐world settings. [ABSTRACT FROM AUTHOR]

Published
2023
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42. SARS-CoV-2 Sero-Surveillance in Greece: Evolution over Time and Epidemiological Attributes during the Pre-Vaccination Pandemic Era

Author

Koureas, Michalis, primary, Bogogiannidou, Zacharoula, additional, Vontas, Alexandros, additional, Kyritsi, Maria A., additional, Mouchtouri, Varvara A., additional, Dadouli, Katerina, additional, Anagnostopoulos, Lemonia, additional, Mina, Paraskevi, additional, Matziri, Alexia, additional, Ntouska, Maria, additional, Tsigaridaki, Maria, additional, Gkiata, Vasiliki, additional, Tsilidis, Konstantinos K., additional, Ntzani, Evangelia E., additional, Prezerakos, Panagiotis, additional, Tsiodras, Sotirios, additional, Speletas, Matthaios, additional, and Hadjichristodoulou, Christos, additional

Published
2022
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43. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture

Author

Zheng, Hou-Feng, Forgetta, Vincenzo, Hsu, Yi-Hsiang, Estrada, Karol, Rosello-Diez, Alberto, Leo, Paul J., Dahia, Chitra L., Park-Min, Kyung Hyun, Tobias, Jonathan H., Kooperberg, Charles, Kleinman, Aaron, Styrkarsdottir, Unnur, Liu, Ching-Ti, Uggla, Charlotta, Evans, Daniel S., Nielson, Carrie M., Walter, Klaudia, Pettersson-Kymmer, Ulrika, McCarthy, Shane, Eriksson, Joel, Kwan, Tony, Jhamai, Mila, Trajanoska, Katerina, Memari, Yasin, Min, Josine, Huang, Jie, Danecek, Petr, Wilmot, Beth, Li, Rui, Chou, Wen-Chi, Mokry, Lauren E., Moayyeri, Alireza, Claussnitzer, Melina, Cheng, Chia-Ho, Cheung, Warren, Medina-Gómez, Carolina, Ge, Bing, Chen, Shu-Huang, Choi, Kwangbom, Oei, Ling, Fraser, James, Kraaij, Robert, Hibbs, Matthew A., Gregson, Celia L., Paquette, Denis, Hofman, Albert, Wibom, Carl, Tranah, Gregory J., Marshall, Mhairi, Gardiner, Brooke B., Cremin, Katie, Auer, Paul, Hsu, Li, Ring, Sue, Tung, Joyce Y., Thorleifsson, Gudmar, Enneman, Anke W., van Schoor, Natasja M., de Groot, Lisette C. P. G. M., van der Velde, Nathalie, Melin, Beatrice, Kemp, John P., Christiansen, Claus, Sayers, Adrian, Zhou, Yanhua, Calderari, Sophie, van Rooij, Jeroen, Carlson, Chris, Peters, Ulrike, Berlivet, Soizik, Dostie, Josée, Uitterlinden, Andre G., Williams, Stephen R., Farber, Charles, Grinberg, Daniel, LaCroix, Andrea Z., Haessler, Jeff, Chasman, Daniel I., Giulianini, Franco, Rose, Lynda M., Ridker, Paul M., Eisman, John A., Nguyen, Tuan V., Center, Jacqueline R., Nogues, Xavier, Garcia-Giralt, Natalia, Launer, Lenore L., Gudnason, Vilmunder, Mellström, Dan, Vandenput, Liesbeth, Amin, Najaf, van Duijn, Cornelia M., Karlsson, Magnus K., Ljunggren, Östen, Svensson, Olle, Hallmans, Göran, Rousseau, François, Giroux, Sylvie, Bussière, Johanne, Arp, Pascal P., Koromani, Fjorda, Prince, Richard L., Lewis, Joshua R., Langdahl, Bente L., Hermann, Pernille A., Jensen, Jens-Erik B., Kaptoge, Stephen, Khaw, Kay-Tee, Reeve, Jonathan, Formosa, Melissa M., Xuereb-Anastasi, Angela, Åkesson, Kristina, McGuigan, Fiona E., Garg, Gaurav, Olmos, Jose M., Zarrabeitia, Maria T., Riancho, Jose A., Ralston, Stuart H., Alonso, Nerea, Jiang, Xi, Goltzman, David, Pastinen, Tomi, Grundberg, Elin, Gauguier, Dominique, Orwoll, Eric S., Karasik, David, Davey-Smith, George, Smith, Albert V., Siggeirsdottir, Kristin, Harris, Tamara B., Zillikens, Carola M., van Meurs, Joyce B. J., Thorsteinsdottir, Unnur, Maurano, Matthew T., Timpson, Nicholas J., Soranzo, Nicole, Durbin, Richard, Wilson, Scott G., Ntzani, Evangelia E., Brown, Matthew A., Stefansson, Kari, Hinds, David A., Spector, Tim, Cupples, Adrienne L., Ohlsson, Claes, Greenwood, Celia M. T., Jackson, Rebecca D., Rowe, David W., Loomis, Cynthia A., Evans, David M., Ackert-Bicknell, Cheryl L., Joyner, Alexandra L., Duncan, Emma L., Kiel, Douglas P., Rivadeneira, Fernando, and Richards, Brent J.

Published
2015
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44. Factors Associated with Healthcare Workers’ (HCWs) Acceptance of COVID-19 Vaccinations and Indications of a Role Model towards Population Vaccinations from a Cross-Sectional Survey in Greece, May 2021

Author

Fotiadis, Konstantinos, primary, Dadouli, Katerina, additional, Avakian, Ioanna, additional, Bogogiannidou, Zacharoula, additional, Mouchtouri, Varvara A., additional, Gogosis, Konstantinos, additional, Speletas, Matthaios, additional, Koureas, Michalis, additional, Lagoudaki, Eleni, additional, Kokkini, Sofia, additional, Bolikas, Emmanouil, additional, Diamantopoulos, Vasilios, additional, Tzimitreas, Athanasios, additional, Papadopoulos, Christos, additional, Farmaki, Evangelia, additional, Sofos, Antonis, additional, Chini, Maria, additional, Tsolia, Maria, additional, Papaevangelou, Vassiliki, additional, Ntzani, Evangelia E., additional, Gikas, Achilleas, additional, Prezerakos, Panagiotis, additional, and Hadjichristodoulou, Christos, additional

Published
2021
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48. Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies

Author

Rodriguez-Fontenla, Cristina, Calaza, Manuel, Evangelou, Evangelos, Valdes, Ana M., Arden, Nigel, Blanco, Francisco J., Carr, Andrew, Chapman, Kay, Deloukas, Panos, Doherty, Michael, Esko, Tõnu, Garcés Aletá, Carlos M., Gomez-Reino Carnota, Juan J., Helgadottir, Hafdis, Hofman, Albert, Jonsdottir, Ingileif, Kerkhof, Hanneke J. M., Kloppenburg, Margreet, McCaskie, Andrew, Ntzani, Evangelia E., Ollier, William E. R., Oreiro, Natividad, Panoutsopoulou, Kalliope, Ralston, Stuart H., Ramos, Yolande F., Riancho, Jose A., Rivadeneira, Fernando, Slagboom, Eline P., Styrkarsdottir, Unnur, Thorsteinsdottir, Unnur, Thorleifsson, Gudmar, Tsezou, Aspasia, Uitterlinden, André G., Wallis, Gillian A., Wilkinson, Mark J., Zhai, Guangju, Zhu, Yanyan, Felson, David T., Ioannidis, John P. A., Loughlin, John, Metspalu, Andres, Meulenbelt, Ingrid, Stefansson, Kari, van Meurs, Joyce B., Zeggini, Eleftheria, Spector, Timothy D., and Gonzalez, Antonio

Published
2014
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49. Factors Associated with Healthcare Workers' (HCWs) Acceptance of COVID-19 Vaccinations and Indications of a Role Model towards Population Vaccinations from a Cross-Sectional Survey in Greece, May 2021

Author

Fotiadis, Konstantinos Dadouli, Katerina Avakian, Ioanna and Bogogiannidou, Zacharoula Mouchtouri, Varvara A. Gogosis, Konstantinos Speletas, Matthaios Koureas, Michalis and Lagoudaki, Eleni Kokkini, Sofia Bolikas, Emmanouil and Diamantopoulos, Vasilios Tzimitreas, Athanasios Papadopoulos, Christos Farmaki, Evangelia Sofos, Antonis Chini, Maria and Tsolia, Maria Papaevangelou, Vassiliki Ntzani, Evangelia E. and Gikas, Achilleas Prezerakos, Panagiotis Hadjichristodoulou, Christos

Abstract

A Knowledge, Attitudes and Practices (KAP) study was conducted at the end of May 2021 engaging 1456 healthcare workers (HCWs) from 20 hospitals throughout Greece. Acceptance of vaccination against coronavirus disease 2019 (COVID-19) was estimated at 77.7%, with lower vaccine acceptance identified in nurses compared to physicians. Fears related to vaccine safety, lack of information and general knowledge about vaccinations, influenza vaccine acceptance, education level and years of practice were among the factors independently associated with vaccine acceptance. A strong association was identified between vaccination of HCWs in each health region and the population coverage, indicating that HCWs may be role models for the general population. Information campaigns should continue despite decisions taken regarding mandatory vaccinations.

Published
2021

50. Association between childhood asthma and history of assisted reproduction techniques: a systematic review and meta-analysis

Author

Tsabouri, Sofia Lavasidis, Georgios Efstathiadou, Anthoula and Papasavva, Margarita Bellou, Vanessa Bergantini, Helio and Priftis, Konstantinos Ntzani, Evangelia E.

Abstract

Genetic and environmental factors during early development may influence lung growth and impact lung function. We performed a meta-analysis of epidemiological studies examining the association between conception history of assisted reproduction techniques (ART) and childhood asthma. We searched PubMed and Embase up to November 2020 for relevant observational studies and synthesized data data under a fixed or random effects model as appropriate. Heterogeneity was assessed using the I-2 metric. We identified 13 individual studies including 3,226,386 participants. We did not observe a statistically significant association between ART and physician-diagnosed asthma (n = 9, random OR 1.16; 95% CI 0.94-1.43; I-2 61%). We observed a statistically significant association between ART and prescription of asthma medications (n = 6, fixed OR 1.27; 95% CI 1.23-1.32; I-2 0%). Wheezing was also associated with ART (n = 4, fixed OR 1.71; 95% CI 1.08-2.72; I-2 0%). When we combined studies using any asthma definition, a statistically significant association was observed (random OR 1.19; 95% CI 1.05-1.34; I-2 80%). Conclusion: The available observational evidence suggests that the risk of asthma is higher among children born after ART. The mechanism and potential sources of bias behind this association are under scrutiny, and further work is needed to establish causality. What is Known: “Positive” epidemiological signals for the association between assisted reproduction techniques and asthma stemming from large studies were not replicated by subsequent research. Any available research synthesis effort so far bears no quantitative aspect. What is New: The available observational evidence suggests that the risk of asthma is higher among children born after ART. The mechanism and potential sources of bias behind this association are under scrutiny.

Published
2021

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