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4 results on '"Nthala, Sharon"'

1. Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study

Author

Epi Infectieziekten Team 1, Chibwana, Marah G., Thole, Herbert W., Anscombe, Cat, Ashton, Philip M., Green, Edward, Barnes, Kayla G., Cornick, Jen, Turner, Ann, Witte, Desiree, Nthala, Sharon, Thom, Chikondi, Kanyandula, Felistas, Ainani, Anna, Mtike, Natasha, Tambala, Hope, N'goma, Veronica, Mwafulirwa, Dorah, Asima, Erick, Morton, Ben, Gmeiner, Markus, Gundah, Zaziwe, Kawalazira, Gift, French, Neil, Feasey, Nicholas, Heyderman, Robert S., Swarthout, Todd D., Jambo, Kondwani C., Epi Infectieziekten Team 1, Chibwana, Marah G., Thole, Herbert W., Anscombe, Cat, Ashton, Philip M., Green, Edward, Barnes, Kayla G., Cornick, Jen, Turner, Ann, Witte, Desiree, Nthala, Sharon, Thom, Chikondi, Kanyandula, Felistas, Ainani, Anna, Mtike, Natasha, Tambala, Hope, N'goma, Veronica, Mwafulirwa, Dorah, Asima, Erick, Morton, Ben, Gmeiner, Markus, Gundah, Zaziwe, Kawalazira, Gift, French, Neil, Feasey, Nicholas, Heyderman, Robert S., Swarthout, Todd D., and Jambo, Kondwani C.

Published
2023

2. Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study

Author

Chibwana, Marah G., primary, Thole, Herbert W., additional, Anscombe, Cat, additional, Ashton, Philip M., additional, Green, Edward, additional, Barnes, Kayla G., additional, Cornick, Jen, additional, Turner, Ann, additional, Witte, Desiree, additional, Nthala, Sharon, additional, Thom, Chikondi, additional, Kanyandula, Felistas, additional, Ainani, Anna, additional, Mtike, Natasha, additional, Tambala, Hope, additional, N’goma, Veronica, additional, Mwafulirwa, Dorah, additional, Asima, Erick, additional, Morton, Ben, additional, Gmeiner, Markus, additional, Gundah, Zaziwe, additional, Kawalazira, Gift, additional, French, Neil, additional, Feasey, Nicholas, additional, Heyderman, Robert S., additional, Swarthout, Todd D., additional, and Jambo, Kondwani C., additional

Published
2023
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3. Differential symptoms among COVID-19 outpatients before and during periods of SARS-CoV-2 Omicron variant dominance in Blantyre, Malawi: a prospective observational study

Author

Chibwana, Marah G., primary, Thole, Herbert W., additional, Anscombe, Cat, additional, Ashton, Philip M., additional, Green, Edward, additional, Barnes, Kayla G., additional, Cornick, Jen, additional, Turner, Ann, additional, Witte, Desiree, additional, Nthala, Sharon, additional, Thom, Chikondi, additional, Kanyandula, Felistas, additional, Ainani, Anna, additional, Mtike, Natasha, additional, Tambala, Hope, additional, N’goma, Veronica, additional, Mwafulirwa, Dorah, additional, Asima, Erick, additional, Morton, Ben, additional, Gmeiner, Markus, additional, Gundah, Zaziwe, additional, Kawalazira, Gift, additional, French, Neil, additional, Feasey, Nicholas, additional, Heyderman, Robert S., additional, Swarthout, Todd D, additional, and Jambo, Kondwani C., additional

Published
2022
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4. Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa

Author

Morton, Ben, Barnes, Kayla G., Anscombe, Catherine, Jere, Khuzwayo, Matambo, Prisca, Mandolo, Jonathan, Kamng’ona, Raphael, Brown, Comfort, Nyirenda, James, Phiri, Tamara, Banda, Ndaziona P., Van Der Veer, Charlotte, Mndolo, Kwazizira S., Mponda, Kelvin, Rylance, Jamie, Phiri, Chimota, Mallewa, Jane, Nyirenda, Mulinda, Katha, Grace, Kambiya, Paul, Jafali, James, Mwandumba, Henry C., Gordon, Stephen B., Cornick, Jennifer, Jambo, Kondwani C., Phulusa, Jacob, Mkandawire, Mercy, Kaimba, Sylvester, Thole, Herbert, Nthala, Sharon, Nsomba, Edna, Keyala, Lucy, Mandala, Peter, Chinoko, Beatrice, Gmeiner, Markus, Kaudzu, Vella, Lissauer, Samantha, Freyne, Bridget, MacPherson, Peter, Swarthout, Todd D., Iroh Tam, Pui-Ying, Sichone, Simon, Ahmadu, Ajisa, Kanjewa, Oscar, Nyasulu, Vita, Chinyama, End, Zuza, Allan, Denis, Brigitte, Storey, Evance, Bondera, Nedson, Matchado, Danford, Chande, Adams, Chingota, Arthur, Ntwea, Chimenya, Mkandawire, Langford, Mhango, Chimwemwe, Lakudzala, Agness, Chaponda, Mphatso, Mwenechanya, Percy, Mvaya, Leonard, Tembo, Dumizulu, Henrion, Marc Y. R., Chirombo, James, Masesa, Clemens, and Gondwe, Joel

Subjects
wa_105, qw_568, mental disorders, wc_505, qw_160, wa_395
Abstract

Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.

Published
2021

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