602 results on '"Nowicki, Marek"'
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2. Studies of temperature-dependent Raman spectra of thin PtSe2 layers on Al2O3 substrate
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Raczyński, Jan, Nowak, Ewelina, Nowicki, Marek, El-Ahmar, Semir, Szybowicz, Mirosław, and Koczorowski, Wojciech
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- 2023
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3. Synthesis of novel bifunctional polyolefins and their application as hydrophobic agents for cotton fabrics
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Januszewski, Rafał, Dutkiewicz, Michał, Nowicki, Marek, and Kownacki, Ireneusz
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- 2023
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4. Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV‐Infected Women
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Tamraz, Bani, Huang, Yong, French, Audrey L, Kassaye, Seble, Anastos, Kathryn, Nowicki, Marek J, Gange, Stephen, Gustafson, Deborah R, Bacchetti, Peter, Greenblatt, Ruth M, Hysi, Pirro G, Aouizerat, Bradley E, and Study, Women's Interagency HIV
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Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,ATP Binding Cassette Transporter ,Subfamily B ,Area Under Curve ,Atazanavir Sulfate ,Chromatography ,High Pressure Liquid ,Citrus sinensis ,Cytochrome P-450 CYP3A Inhibitors ,Diarrhea ,Dose-Response Relationship ,Drug ,Female ,Genotype ,HIV Infections ,HIV Protease Inhibitors ,Hair ,Heroin Dependence ,Humans ,Hydrogen-Ion Concentration ,Longitudinal Studies ,MicroRNAs ,Polymorphism ,Single Nucleotide ,Racial Groups ,Receptors ,Cell Surface ,Tandem Mass Spectrometry ,Women's Interagency HIV Study ,Pharmacology & Pharmacy ,Pharmacology and pharmaceutical sciences - Abstract
SORCS2 rs73208473 was recently associated with decreased atazanavir (ATV) concentration in the hair of women with seropositive HIV. Herein, we report on a pharmacogenetic study of women with seropositive HIV demonstrating a similar association between rs73208473 and dose-adjusted plasma ATV concentration in African Americans.
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- 2020
5. Unraveling the Impact of Open-Cage Silsesquioxane Modifiers on Material Properties in Epoxy Resin Composites
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Grzelak, Magdalena, primary, Szołyga, Mariusz, additional, Nowicki, Marek, additional, Sałasińska, Kamila, additional, and Celiński, Maciej, additional
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- 2024
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6. Magnetically Recyclable Borane Lewis Acid Catalyst for Hydrosilylation of Imines and Reductive Amination of Carbonyls.
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Saptal, Vitthal B., Ranjan, Prabodh, Zbořil, Radek, Nowicki, Marek, and Walkowiak, Jędrzej
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ACID catalysts ,LEWIS acids ,WASTE recycling ,FERRIC oxide ,REDUCING agents - Abstract
Fluorinated arylborane‐based Lewis acid catalysts have shown remarkable activity and serve as ideal examples of transition metal‐free catalysts for diverse organic transformations. However, their homogeneous nature poses challenges in terms of recyclability and separation from reaction mixtures. This work presents an efficient technique for the heterogenization of boron Lewis acid catalysts by anchoring Piers' borane to allyl‐functionalized iron oxide. This catalyst demonstrates excellent activity in the hydrosilylation of imines and the reductive amination of carbonyls using various silanes as reducing agents under mild reaction conditions. The catalyst exhibits broad tolerance towards a wide range of functional substrates. Furthermore, it exhibits good recyclability and can be easily separated from the products using an external magnetic field. This work represents a significant advance in the development of sustainable heterogenous metal‐free catalysts for organic transformations. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Performance Evaluation of Java/PCJ Implementation of Parallel Algorithms on the Cloud
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Nowicki, Marek, Górski, Łukasz, Bała, Piotr, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Balis, Bartosz, editor, B. Heras, Dora, editor, Antonelli, Laura, editor, Bracciali, Andrea, editor, Gruber, Thomas, editor, Hyun-Wook, Jin, editor, Kuhn, Michael, editor, Scott, Stephen L., editor, Unat, Didem, editor, and Wyrzykowski, Roman, editor
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- 2021
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8. Reduction-adsorption of chromium(VI) by using IL-imprinted resin -innovative solution for water purification
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Filipowiak, Kinga, Wieszczycka, Karolina, Buchwald, Tomasz, Nowicki, Marek, Wójcik, Grzegorz, Aksamitowski, Przemysław, and Staszak, Katarzyna
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- 2021
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9. Changes in Urinary Biomarkers Over 10 Years Is Associated With Viral Suppression in a Prospective Cohort of Women Living With HIV
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Baxi, Sanjiv M, Scherzer, Rebecca, Jotwani, Vasantha, Estrella, Michelle M, Abraham, Alison G, Parikh, Chirag R, Bennett, Michael R, Cohen, Mardge H, Nowicki, Marek J, Gustafson, Deborah R, Sharma, Anjali, Young, Mary A, and Shlipak, Michael G
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Medical Microbiology ,Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Hepatitis ,Women's Health ,Emerging Infectious Diseases ,Health Disparities ,Hepatitis - C ,Minority Health ,Kidney Disease ,Digestive Diseases ,Liver Disease ,Infectious Diseases ,Sexually Transmitted Infections ,Prevention ,Clinical Research ,HIV/AIDS ,Infection ,Good Health and Well Being ,Adult ,Albuminuria ,Alpha-Globulins ,Anti-Retroviral Agents ,Biomarkers ,Creatinine ,Female ,HIV Infections ,Humans ,Interleukin-18 ,Middle Aged ,Prospective Studies ,Renal Insufficiency ,Sustained Virologic Response ,biomarkers ,chronic renal insufficiency ,HIV ,WIHS ,women ,Womenʼs Interagency HIV Study ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
BackgroundUrine biomarkers have helped identify persons at risk for progressing to kidney disease in the setting of HIV infection. We explored factors associated with changes in 3 urine biomarkers over 10 years among women living with HIV.MethodsProspective cohort of 294 HIV-infected women from the multicenter Women's Interagency HIV Study. Predictors included HIV viral and immunological parameters, comorbid conditions, and health-related behaviors. Outcomes were patterns of changes of urine interleukin-18 (IL-18), albumin-to-creatinine ratio (ACR), and alpha-1-microglobulin (α1m) over 10 years. We used quantile regression to examine patterns of change in each urine biomarker during follow-up and multivariable analysis of variance regression to identify predictors of biomarker changes.ResultsOver 10 years, the median concentrations of IL-18 declined from 120 to 64 pg/mL, α1m rose from 0.7 to 1.5 ng/mL, and ACR remained stable (9-8 mg/g). In multivariate analyses, the strongest predictors of increases in IL-18 were higher baseline body mass index, increase in waist circumference, higher follow-up HIV viral load, lower follow-up CD4 cell count, hepatitis C virus (HCV) coinfection, and higher follow-up high density lipoprotein cholesterol. Predictors of increasing concentration of α1m were lower CD4 cell counts, higher diastolic blood pressure, HCV coinfection, and smoking. Finally, determinants of ACR increases during follow-up were higher follow-up diastolic blood pressure, HCV coinfection, higher follow-up HIV viral load, and triglyceride concentration.ConclusionsOver 10 years, HIV disease status had different associations with each urine biomarker under study. Overall, the associations with changes in each biomarker support research into their use for longitudinal monitoring of kidney health.
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- 2017
10. Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women
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Ascher, Simon B, Scherzer, Rebecca, Peralta, Carmen A, Tien, Phyllis C, Grunfeld, Carl, Estrella, Michelle M, Abraham, Alison, Gustafson, Deborah R, Nowicki, Marek, Sharma, Anjali, Cohen, Mardge H, Butch, Anthony W, Young, Mary A, Bennett, Michael R, and Shlipak, Michael G
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Infectious Diseases ,Hypertension ,HIV/AIDS ,Cardiovascular ,Clinical Research ,Kidney Disease ,Sexually Transmitted Infections ,Prevention ,Renal and urogenital ,Good Health and Well Being ,Acute Kidney Injury ,Adult ,Biomarkers ,Female ,Glomerular Filtration Rate ,HIV ,HIV Infections ,Humans ,Incidence ,Kidney ,Prevalence ,Retrospective Studies ,United States ,albuminuria ,glomerular filtration rate ,hypertension ,kidney disease ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences - Abstract
Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injury: α-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid-binding protein, N-acetyl-β-d-glucosaminidase, and α1-acid-glycoprotein. We used multivariable Poisson regression to evaluate associations of kidney biomarkers with incident hypertension, defined as 2 consecutive visits of antihypertensive medication use. During a median follow-up of 9.6 years, 288 HIV-infected women (35%) developed hypertension. Among the HIV-infected women, higher urine albumin-to-creatinine ratio was independently associated with incident hypertension (relative risk =1.13 per urine albumin-to-creatinine ratio doubling, 95% confidence interval, 1.07-1.20), as was lower estimated glomerular filtration rate (relative risk =1.10 per 10 mL/min/1.73 m2 lower estimated glomerular filtration rate; 95% confidence interval, 1.04-1.17). No tubular injury and dysfunction biomarkers were independently associated with incident hypertension in HIV-infected women. In contrast, among the HIV-uninfected women, urine albumin-to-creatinine ratio was not associated with incident hypertension, whereas higher urine interleukin-18, α1-acid-glycoprotein, and N-acetyl-β-d-glucosaminidase levels were significantly associated with incident hypertension. These findings suggest that early glomerular injury and kidney dysfunction may be involved in the pathogenesis of hypertension in HIV-infected people. The associations of tubular markers with hypertension in HIV-uninfected women should be validated in other studies.
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- 2017
11. Increased glucose transporter-1 expression on intermediate monocytes from HIV-infected women with subclinical cardiovascular disease
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Butterfield, Tiffany R, Hanna, David B, Kaplan, Robert C, Kizer, Jorge R, Durkin, Helen G, Young, Mary A, Nowicki, Marek J, Tien, Phyllis C, Golub, Elizabeth T, Floris-Moore, Michelle A, Titanji, Kehmia, Fischl, Margaret A, Heath, Sonya L, Martinson, Jefferey, Crowe, Suzanne M, Palmer, Clovis S, Landay, Alan L, and Anzinger, Joshua J
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Biomedical and Clinical Sciences ,Immunology ,Cardiovascular ,HIV/AIDS ,Heart Disease ,Good Health and Well Being ,ADP-ribosyl Cyclase 1 ,Adult ,Anti-Retroviral Agents ,CD4 Lymphocyte Count ,Cardiovascular Diseases ,Carotid Arteries ,Carotid Intima-Media Thickness ,Female ,Flow Cytometry ,Glucose Transporter Type 1 ,HIV Infections ,Humans ,Longitudinal Studies ,Membrane Glycoproteins ,Middle Aged ,Monocytes ,T-Lymphocytes ,cardiovascular disease ,GLUT1 ,HIV ,monocyte ,T cell ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectivePeople living with HIV (PLWH) have chronic immune activation and increased cardiovascular disease (CVD) risk. Activation of monocytes and T lymphocytes causes upregulation of glucose transporter-1 (GLUT1) for efficient function. PLWH have an increased percentage of GLUT1-expressing monocytes and T lymphocytes, but it is unclear if these cells are associated with CVD. We evaluated the expression of GLUT1 and CD38 on monocyte and T lymphocyte populations from HIV-infected women with subclinical CVD.MethodsParticipants with more than 75th percentile (n = 15) and less than 25th percentile (n = 15) age-adjusted intima-media thickness (IMT) at the right common carotid artery and bifurcation were identified from the Women's Interagency HIV Study. Groups were matched by age, race/ethnicity, smoking status, and CD4 cell count. All women were receiving suppressive antiretroviral therapy except for one high and one low IMT participant. Monocyte and T lymphocyte populations were evaluated for GLUT1 and CD38 expression using flow cytometry.ResultsIntermediate monocytes from high IMT women had significantly increased expression of GLUT1 (310 MFI vs. 210 MFI, P = 0.024) (66.4% vs. 48.5%, P = 0.031) and CD38 (339 MFI vs. 211 MFI, P = 0.002) (10.5% vs. 3.8%, P = 0.0002) compared with women with low IMT. High and low IMT participants showed no differences in GLUT1 or CD38 expression on classical monocytes, nonclassical monocytes, CD4 and CD8 T lymphocytes.ConclusionGLUT1-expressing intermediate monocytes are elevated in HIV-infected women with subclinical CVD. These cells may contribute to development of CVD in PLWH and could be a novel target to limit inflammation.
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- 2017
12. A green approach for hybrid material preparation based on carbon nanotubes/lignosulfonate decorated with silver nanostructures for electrocatalytic sensing of H2O2
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Płócienniczak, Patrycja, Rębiś, Tomasz, Nowicki, Marek, and Milczarek, Grzegorz
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- 2021
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13. Microcapsules containing task-specific ionic liquids for Zn(II) and Cu(II) recovery from dilute aqueous solutions
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Wieszczycka, Karolina, Filipowiak, Kinga, Buchwald, Tomasz, and Nowicki, Marek
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- 2020
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14. Reducing friction and engine vibrations with trace amounts of carbon nanotubes in the lubricating oil
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Kałużny, Jarosław, Waligórski, Marek, Szymański, Grzegorz M., Merkisz, Jerzy, Różański, Jacek, Nowicki, Marek, Al Karawi, Mohanad, and Kempa, Krzysztof
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- 2020
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15. 3D Spongin Scaffolds as Templates for Electro-Assisted Deposition of Selected Iron Oxides.
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Nowacki, Krzysztof, Kubiak, Anita, Nowicki, Marek, Tsurkan, Dmitry, Ehrlich, Hermann, and Jesionowski, Teofil
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SPONGE (Material) ,FERRIC oxide ,IRON oxides ,HEAVY metals removal (Sewage purification) ,SPONGES (Invertebrates) ,CALCIUM ions - Abstract
The skeletons of marine sponges are ancient biocomposite structures in which mineral phases are formed on 3D organic matrices. In addition to calcium- and silicate-containing biominerals, iron ions play an active role in skeleton formation in some species of bath sponges in the marine environment, which is a result of the biocorrosion of the metal structures on which these sponges settle. The interaction between iron ions and biopolymer spongin has motivated the development of selected extreme biomimetics approaches with the aim of creating new functional composites to use in environmental remediation and as adsorbents for heavy metals. In this study, for the first time, microporous 3D spongin scaffolds isolated from the cultivated marine bath sponge Hippospongia communis were used for electro-assisted deposition of iron oxides such as goethite [α-FeO(OH)] and lepidocrocite [γ-FeO(OH)]. The obtained iron oxide phases were characterized with the use of scanning electron microscopy, FTIR, and X-ray diffraction. In addition, mechanisms of electro-assisted deposition of iron oxides on the surface of spongin, as a sustainable biomaterial, are proposed and discussed. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Synthesis and properties of hybrid materials obtained via additive cross-linking of liquid polybutadiene rubber with H-Si containing reagents
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Januszewski, Rafał, Dutkiewicz, Michał, Nowicki, Marek, and Kownacki, Ireneusz
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- 2020
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17. Determining the structure of a layer under 2D-cover: the case of Pb underneath epitaxial graphene on Ru(0001)
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Morawski, Ireneusz, Wang, Ying, Dawczak-Dębicki, Hubert, Stobiecki, Feliks, Lewandowski, Mikołaj, and Nowicki, Marek
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- 2020
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18. Unveiling the Interplay between a Au(100) Electrode, Adsorbed TTMAPP Porphyrin Cations, and Iodide Anions: An EC-STM and CV Study
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Kosmala, Tomasz, primary, Wasielewski, Radosław, additional, Nowicki, Marek, additional, and Wandelt, Klaus, additional
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- 2024
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19. Use of urine biomarker-derived clusters to predict the risk of chronic kidney disease and all-cause mortality in HIV-infected women
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Scherzer, Rebecca, Lin, Haiqun, Abraham, Alison, Thiessen-Philbrook, Heather, Parikh, Chirag R, Bennett, Michael, Cohen, Mardge H, Nowicki, Marek, Gustafson, Deborah R, Sharma, Anjali, Young, Mary, Tien, Phyllis, Jotwani, Vasantha, and Shlipak, Michael G
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Biomedical and Clinical Sciences ,Clinical Sciences ,Infectious Diseases ,Kidney Disease ,Prevention ,Sexually Transmitted Infections ,HIV/AIDS ,Clinical Research ,Infection ,Renal and urogenital ,Good Health and Well Being ,Acetylglucosaminidase ,Adult ,Alpha-Globulins ,Biomarkers ,Creatinine ,Cystatin C ,Fatty Acid-Binding Proteins ,Female ,HIV Infections ,HIV-1 ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Interleukin-18 ,Lipocalin-2 ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,Renal Insufficiency ,Chronic ,Risk Factors ,biomarker ,chronic kidney disease ,cluster analysis ,HIV ,risk discrimination ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundAlthough individual urine biomarkers are associated with chronic kidney disease (CKD) incidence and all-cause mortality in the setting of HIV infection, their combined utility for prediction remains unknown.MethodsWe measured eight urine biomarkers shown previously to be associated with incident CKD and mortality risk among 902 HIV-infected women in the Women's Interagency HIV Study: N-acetyl-β-d-glucosaminidase (NAG), kidney injury molecule-1 (KIM-1), alpha-1 microglobulin (α1m), interleukin 18, neutrophil gelatinase-associated lipocalin, albumin-to-creatinine ratio, liver fatty acid-binding protein and α-1-acid-glycoprotein. A group-based cluster method classified participants into three distinct clusters using the three most distinguishing biomarkers (NAG, KIM-1 and α1m), independent of the study outcomes. We then evaluated associations of each cluster with incident CKD (estimated glomerular filtration rate
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- 2016
20. Isolated Hepatitis B Core Antibody Status Is Not Associated With Accelerated Liver Disease Progression in HIV/Hepatitis C Coinfection
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French, Audrey L, Hotton, Anna, Young, Mary, Nowicki, Marek, Augenbraun, Michael, Anastos, Kathryn, Seaberg, Eric, Rosenberg, William, and Peters, Marion G
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Medical Microbiology ,Biomedical and Clinical Sciences ,Sexually Transmitted Infections ,Digestive Diseases ,Emerging Infectious Diseases ,Hepatitis ,Liver Disease ,Hepatitis - C ,Clinical Research ,Infectious Diseases ,Chronic Liver Disease and Cirrhosis ,HIV/AIDS ,Substance Misuse ,Women's Health ,Infection ,Good Health and Well Being ,Adult ,Biomarkers ,CD4 Lymphocyte Count ,Case-Control Studies ,Coinfection ,DNA ,Viral ,Disease Progression ,Female ,HIV Infections ,Hepatitis B ,Hepatitis B Antibodies ,Hepatitis B Core Antigens ,Hepatitis C ,Humans ,Risk Factors ,United States ,HIV ,hepatitis C ,hepatitis B ,isolated anti-HBc ,liver disease progression ,hepatic fibrosis ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
BackgroundIsolated hepatitis B core antibody (anti-HBc) is a common serologic finding in HIV-infected persons, but the clinical significance is uncertain. We studied HIV/hepatitis C virus (HCV)-infected women over time to determine whether the trajectory of liver disease progression is affected by isolated anti-HBc serologic status.MethodsWe performed serial enhanced liver fibrosis (ELF) markers on HIV/HCV-coinfected women to assess liver disease progression trajectory over time comparing women with isolated anti-HBc to women with either negative HB serologies, anti-HBs alone, or anti-HBc and anti-HBs. ELF, a serum marker that combines direct markers of extracellular matrix remodeling and fibrosis, was performed on serum stored biannually. Women with at least 3 ELF determinations and persistent HCV RNA positivity were included.ResultsThree hundred forty-four women, including 132 with isolated anti-HBc and 212 with other serologic findings, were included. A median of 6 (interquartile range, 5-7) biannual ELF values was available for each woman, totaling 2119 visits. ELF increased over time from a median of 9.07 for women with isolated anti-HBc and 9.10 for those without isolated anti-HBc to 9.83 and 9.88, respectively, with no difference in degree of change or slope in the mixed-effects model including age, race, CD4 count, antiretroviral therapy, and drug and alcohol use. Factors independently associated with liver disease progression were older age, lower CD4, antiretroviral therapy nonuse, and Hispanic ethnicity.ConclusionIsolated anti-HBc serologic status was not associated with accelerated liver disease progression over a median of 9.5 years among HIV/HCV-coinfected women.
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- 2016
21. CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception
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Sciaranghella, Gaia, Wang, Cuiwei, Hu, Haihong, Anastos, Kathryn, Merhi, Zaher, Nowicki, Marek, Stanczyk, Frank Z, Greenblatt, Ruth M, Cohen, Mardge, Golub, Elizabeth T, Watts, D Heather, Alter, Galit, Young, Mary A, and Tsibris, Athe MN
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Medical Microbiology ,Reproductive Medicine ,Biomedical and Clinical Sciences ,Immunology ,Contraception/Reproduction ,HIV/AIDS ,Clinical Research ,Good Health and Well Being ,Adult ,CD4-Positive T-Lymphocytes ,CD8-Positive T-Lymphocytes ,Contraception ,Contraceptives ,Oral ,Combined ,Educational Status ,Female ,HIV Seronegativity ,Humans ,Levonorgestrel ,Medroxyprogesterone Acetate ,Receptors ,CCR5 ,Receptors ,CXCR4 ,T-Lymphocyte Subsets ,HIV-1 ,hormonal contraception ,CCR5 ,medroxyprogesterone acetate ,levonorgestrel ,oral contraceptive pills ,peripheral blood mononuclear cells ,CD4 ,CXCR4 ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.
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- 2015
22. PCJ Java library as a solution to integrate HPC, Big Data and Artificial Intelligence workloads
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Nowicki, Marek, Górski, Łukasz, and Bała, Piotr
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- 2021
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23. APOL1 Genotype and Glomerular and Tubular Kidney Injury in Women With HIV
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Jotwani, Vasantha, Shlipak, Michael G, Scherzer, Rebecca, Parekh, Rulan S, Kao, WH Linda, Bennett, Michael, Cohen, Mardge H, Nowicki, Marek, Sharma, Anjali, Young, Mary, Tien, Phyllis C, Parikh, Chirag R, and Estrella, Michelle M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Infectious Diseases ,Genetics ,Kidney Disease ,Minority Health ,Prevention ,Sexually Transmitted Infections ,Women's Health ,HIV/AIDS ,Clinical Research ,Health Disparities ,Renal and urogenital ,Good Health and Well Being ,Acute-Phase Proteins ,Adult ,Black or African American ,Albuminuria ,Alpha-Globulins ,Apolipoprotein L1 ,Apolipoproteins ,Case-Control Studies ,Creatinine ,Female ,Genetic Predisposition to Disease ,Genotype ,HIV Infections ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Interleukin-18 ,Kidney Glomerulus ,Kidney Tubules ,Lipocalin-2 ,Lipocalins ,Lipoproteins ,HDL ,Membrane Glycoproteins ,Middle Aged ,Polymorphism ,Single Nucleotide ,Prospective Studies ,Proto-Oncogene Proteins ,Receptors ,Virus ,Renal Insufficiency ,Chronic ,Serum Albumin ,APOL1 genotype ,risk variant ,risk allele ,G1 allele ,G2 allele ,single-nucleotide polymorphism ,albumin-creatinine ratio ,proteinuria ,tubular injury biomarker ,apolipoprotein L1 ,kidney disease ,renal function ,glomerular injury ,African American ,Women's Interagency HIV Study ,Women’s Interagency HIV Study ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundAPOL1 genotype is associated with advanced kidney disease in African Americans, but the pathogenic mechanisms are unclear. Here, associations of APOL1 genotype with urine biomarkers of glomerular and tubular injury and kidney function decline were evaluated.Study designObservational study.Setting & participants431 human immunodeficiency virus (HIV)-infected African American women enrolled in Women's Interagency HIV Study (WIHS).PredictorAPOL1 genotype.OutcomesAlbumin-creatinine ratio (ACR), 4 tubular injury biomarkers (interleukin 18 [IL-18], kidney injury molecule 1 [KIM-1], neutrophil gelatinase-associated lipocalin [NGAL], and α1-microglobulin [A1M]), and kidney function estimated using the CKD-EPI cystatin C equation.MeasurementsParticipants were genotyped for APOL1 single-nucleotide polymorphisms rs73885319 (G1 allele) and rs71785313 (G2 allele). Urine biomarkers were measured using stored samples from 1999-2000. Cystatin C was measured using serum collected at baseline and 4- and 8-year follow-ups.ResultsAt baseline, ACRs were higher among 47 women with 2 APOL1 risk alleles versus 384 women with 0/1 risk allele (median, 24 vs 11mg/g; P30 (95% CI, 1.17-3.44) mg/g after multivariable adjustment. APOL1 genotype showed little association with urine IL-18:Cr ratio, KIM-1:Cr ratio, and NGAL:Cr ratio (estimates of -5% [95% CI, -24% to 18%], -20% [95% CI, -36% to -1%], and 10% [95% CI, -26% to 64%], respectively) or detectable urine A1M (prevalence ratio, 1.13; 95% CI, 0.65-1.97) in adjusted analyses. Compared with women with 0/1 allele, women with 2 risk alleles had faster eGFR decline, by 1.2 (95% CI, 0.2 to 2.2) mL/min/1.73m(2) per year, and 1.7- and 3.4-fold greater rates of incident chronic kidney disease (95% CI, 1.1 to 2.5) and 10% annual eGFR decline (95% CI, 1.7 to 6.7), respectively, with minimal attenuation after adjustment for glomerular and tubular injury biomarker levels.LimitationsResults may not be generalizable to men.ConclusionsAmong HIV-infected African American women, APOL1-associated kidney injury appears to localize to the glomerulus, rather than the tubules.
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- 2015
24. Fault-Tolerance Mechanisms for the Java Parallel Codes Implemented with the PCJ Library
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Szynkiewicz, Michał, Nowicki, Marek, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Wyrzykowski, Roman, editor, Dongarra, Jack, editor, Deelman, Ewa, editor, and Karczewski, Konrad, editor
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- 2018
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25. Performance Comparison of Graph BFS Implemented in MapReduce and PGAS Programming Models
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Ryczkowska, Magdalena, Nowicki, Marek, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Wyrzykowski, Roman, editor, Dongarra, Jack, editor, Deelman, Ewa, editor, and Karczewski, Konrad, editor
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- 2018
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26. Big Data Analytics in Java with PCJ Library: Performance Comparison with Hadoop
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Nowicki, Marek, Ryczkowska, Magdalena, Górski, Łukasz, Bala, Piotr, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Wyrzykowski, Roman, editor, Dongarra, Jack, editor, Deelman, Ewa, editor, and Karczewski, Konrad, editor
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- 2018
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27. Evaluation of the Parallel Performance of the Java and PCJ on the Intel KNL Based Systems
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Nowicki, Marek, Górski, Łukasz, Bała, Piotr, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Wyrzykowski, Roman, editor, Dongarra, Jack, editor, Deelman, Ewa, editor, and Karczewski, Konrad, editor
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- 2018
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28. Association of Markers of Hemostasis With Death in HIV-Infected Women
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Kiefer, Elizabeth, Hoover, Donald R, Shi, Qiuhu, Kuniholm, Mark H, Augenbraun, Michael, Cohen, Mardge H, Golub, Elizabeth T, Kaplan, Robert C, Liu, Chenglong, Nowicki, Marek, Tien, Phyllis C, Tracy, Russell P, and Anastos, Kathryn
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Prevention ,Clinical Research ,Infectious Diseases ,HIV/AIDS ,Good Health and Well Being ,Adult ,Biomarkers ,Factor VIII ,Female ,Fibrin Fibrinogen Degradation Products ,HIV Infections ,Hemostasis ,Humans ,Middle Aged ,Multivariate Analysis ,Plasminogen Activator Inhibitor 1 ,Predictive Value of Tests ,Prospective Studies ,Protein S ,United States ,HIV infection ,women ,hemostasis ,D-dimer ,death ,biomarkers ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
: In HIV negatives, markers of hemostasis, including D-dimer, factor VIII, plasminogen activator inhibitor-1 antigen (PAI-1), and total protein S are associated with all-cause and cardiovascular disease mortality. In HIV positives, studies of D-dimer and factor VIII with death were limited to short follow-up; associations of PAI-1 and total protein S with death have not been examined. In 674 HIV-infected women from the Women's Interagency HIV Study, markers from the first visit after enrollment were exposures of interest in multivariate analyses of death (AIDS and non-AIDS) in separate models at 5 and 16 years. There were 87 AIDS and 44 non-AIDS deaths at 5 years, and 159 AIDS and 113 non-AIDS deaths at 16 years. An inverse association of total protein S quartiles with non-AIDS deaths was observed at 5 (P trend = 0.002) and 16 years (P trend = 0.02); there was no association with AIDS deaths. The third quartile of PAI-1 was associated with AIDS deaths at 5 [hazard ratio (HR) = 4.0; 95% confidence interval (CI): 1.9 to 8.4] and 16 years (HR = 3.4; 95% CI: 1.9 to 5.9); and with non-AIDS deaths at 5 years (HR = 4.8; 95% CI: 1.6 to 13.9). D-dimer and factor VIII were not associated with AIDS or non-AIDS death at 5 or 16 years. Lower total Protein S was a consistent marker of non-AIDS death. We found no association between D-dimer with AIDS or non-AIDS death, in contrast to previous studies showing increased short-term (
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- 2014
29. Corrigendum to “A green approach for hybrid material preparation based on carbon nanotubes/lignosulfonate decorated with silver nanostructures for electrocatalytic sensing of H2O2” [J. Electroanal. Chem. 880 (2021) 114896]
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Płócienniczak, Patrycja, Rębiś, Tomasz, Nowicki, Marek, and Milczarek, Grzegorz
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- 2024
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30. Performance Evaluation of Java/PCJ Implementation of Parallel Algorithms on the Cloud
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Nowicki, Marek, primary, Górski, Łukasz, additional, and Bała, Piotr, additional
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- 2021
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31. Serum Albumin and Kidney Function Decline in HIV-Infected Women
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Lang, Joshua, Scherzer, Rebecca, Tien, Phyllis C, Parikh, Chirag R, Anastos, Kathryn, Estrella, Michelle M, Abraham, Alison G, Sharma, Anjali, Cohen, Mardge H, Butch, Anthony W, Nowicki, Marek, Grunfeld, Carl, and Shlipak, Michael G
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Biomedical and Clinical Sciences ,Clinical Sciences ,HIV/AIDS ,Infectious Diseases ,Prevention ,Kidney Disease ,Clinical Research ,Renal and urogenital ,AIDS-Associated Nephropathy ,Adult ,Creatinine ,Disease Progression ,Female ,Glomerular Filtration Rate ,HIV ,Humans ,Kidney Function Tests ,Prognosis ,Renal Insufficiency ,Chronic ,Retrospective Studies ,Risk Factors ,Serum Albumin ,United States ,Albumin ,kidney function ,incident reduced estimated ,glomerular filtration rate ,albuminuria ,disease trajectory ,chronic kidney disease (CKD) progression ,incident reduced estimated glomerular filtration rate ,Public Health and Health Services ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundSerum albumin concentrations are a strong predictor of mortality and cardiovascular disease in human immunodeficiency virus (HIV)-infected individuals. We studied the longitudinal associations between serum albumin levels and kidney function decline in a population of HIV-infected women.Study designRetrospective cohort analysis.Setting & participantsStudy participants were recruited from the Women's Interagency HIV Study (WIHS), a large observational study designed to understand risk factors for the progression of HIV infection in women living in urban communities. 908 participants had baseline assessment of kidney function and 2 follow-up measurements over an average of 8 years.PredictorThe primary predictor was serum albumin concentration.OutcomesWe examined annual change in kidney function. Secondary outcomes included rapid kidney function decline and incident reduced estimated glomerular filtration rate (eGFR).MeasurementsKidney function decline was determined by cystatin C-based (eGFR(cys)) and creatinine-based eGFR (eGFR(cr)) at baseline and follow-up. Each model was adjusted for kidney disease and HIV-related risk factors using linear and relative risk regression.ResultsAfter multivariate adjustment, each 0.5-g/dL decrement in baseline serum albumin concentration was associated with a 0.56-mL/min faster annual decline in eGFR(cys) (P < 0.001), which was attenuated only slightly to 0.55 mL/min/1.73 m(2) after adjustment for albuminuria. Results were similar whether using eGFR(cys) or eGFR(cr). In adjusted analyses, each 0.5-g/dL lower baseline serum albumin level was associated with a 1.71-fold greater risk of rapid kidney function decline (P < 0.001) and a 1.72-fold greater risk of incident reduced eGFR (P < 0.001).LimitationsThe cohort is composed of only female participants from urban communities within the United States.ConclusionsLower serum albumin levels were associated strongly with kidney function decline and incident reduced eGFRs in HIV-infected women independent of HIV disease status, body mass index, and albuminuria.
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- 2014
32. Donor-Derived West Nile Virus Infection in Solid Organ Transplant Recipients
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Winston, Drew J, Vikram, Holenarasipur R, Rabe, Ingrid B, Dhillon, Gundeep, Mulligan, David, Hong, Johnny C, Busuttil, Ronald W, Nowicki, Marek J, Mone, Thomas, Civen, Rachel, Tecle, Selam A, Trivedi, Kavita K, and Hocevar, Susan N
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Infectious Diseases ,Orphan Drug ,Biodefense ,Vaccine Related ,Rare Diseases ,Clinical Research ,Vector-Borne Diseases ,Emerging Infectious Diseases ,Neurosciences ,Genetics ,Prevention ,West Nile Virus ,Transplantation ,Organ Transplantation ,Infection ,Good Health and Well Being ,Antibodies ,Viral ,Humans ,Immunoglobulin M ,Immunosuppressive Agents ,Kidney Transplantation ,Liver Transplantation ,Lung Transplantation ,Lymph Nodes ,Male ,Middle Aged ,RNA ,Viral ,Spleen ,Tissue Donors ,West Nile Fever ,West Nile virus ,Donor-derived infection ,West Nile Virus Transplant-Associated Transmission Investigation Team ,Medical and Health Sciences ,Surgery - Abstract
We describe four solid-organ transplant recipients with donor-derived West Nile virus (WNV) infection (encephalitis 3, asymptomatic 1) from a common donor residing in a region of increased WNV activity. All four transplant recipients had molecular evidence of WNV infection in their serum and/or cerebrospinal fluid (CSF) by reverse transcription polymerase chain reaction (RT-PCR) testing. Serum from the organ donor was positive for WNV IgM but negative for WNV RNA, whereas his lymph node and spleen tissues tested positive for WNV by RT-PCR. Combination therapy included intravenous immunoglobulin (4 cases), interferon (3 cases), fresh frozen plasma with WNV IgG (2 cases), and ribavirin (1 case). Two of the four transplant recipients survived.Review of the 20 published cases of organ-derived WNV infection found that this infection is associated with a high incidence of neuroinvasive disease (70%) and severe morbidity and mortality (30%). Median time to onset of symptomatic WNV infection was 13 days after transplantation (range 5-37 days). Initial unexplained fever unresponsive to antibiotic therapy followed by rapid onset of neurologic deficits was the most common clinical presentation. Confirmation of infection was made by testing serum and CSF for both WNV RNA by RT-PCR and WNV IgM by serological assays. Treatment usually included supportive care, reduction of immunosuppression, and frequent intravenous immunoglobulin. The often negative results for WNV by current RT-PCR and serological assays and the absence of clinical signs of acute infection in donors contribute to the sporadic occurrence of donor-derived WNV infection. Potential organ donors should be assessed for unexplained fever and neurological symptoms, particularly if they reside in areas of increased WNV activity.
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- 2014
33. Does HIV Infection Promote Early Kidney Injury in Women?
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Jotwani, Vasantha, Scherzer, Rebecca, Abraham, Alison, Estrella, Michelle M, Bennett, Michael, Devarajan, Prasad, Anastos, Kathryn, Cohen, Mardge H, Nowicki, Marek, Sharma, Anjali, Young, Mary, Tien, Phyllis C, Grunfeld, Carl, Parikh, Chirag R, and Shlipak, Michael G
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Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Kidney Disease ,Prevention ,HIV/AIDS ,Sexually Transmitted Infections ,Infectious Diseases ,Clinical Research ,Infection ,Renal and urogenital ,Good Health and Well Being ,Adult ,Aged ,Albuminuria ,Antiretroviral Therapy ,Highly Active ,Biomarkers ,CD4 Lymphocyte Count ,Creatinine ,Cross-Sectional Studies ,Female ,HIV Infections ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Interleukin-18 ,Kidney Diseases ,Membrane Glycoproteins ,Middle Aged ,Prospective Studies ,Receptors ,Virus ,Risk Factors ,Viral Load ,Young Adult ,Microbiology ,Virology ,Clinical sciences ,Medical microbiology - Abstract
BackgroundIn HIV-infected women, urine concentrations of novel tubulointerstitial injury markers, interleukin-18 (IL-18) and kidney injury marker-1 (KIM-1), are associated with kidney function decline and all-cause mortality. We hypothesized that HIV-infected individuals with preserved kidney filtration function would have more extensive kidney injury, as determined by urine injury markers, compared to the uninfected controls, and that risk factors for tubulointerstitial injury would differ from risk factors for albuminuria.MethodsIn this cross-sectional study, we compared urine concentrations of IL-18, KIM-1 and albumin-to-creatinine ratio (ACR) in 908 HIV-infected and 289 HIV-uninfected women enrolled in the Women's Interagency HIV Study, utilizing stored urine specimens from visits between 1999 and 2000.ResultsAfter multivariate-adjusted linear regression analysis, mean urine concentrations were higher in HIV-infected individuals by 38% for IL-18 (P
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- 2014
34. Metallodendrimers Unveiled: Investigating the Formation and Features of Double-Decker Silsesquioxane-Based Silylferrocene Dendrimers
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Mrzygłód, Aleksandra, primary, García Armada, M. Pilar, additional, Rzonsowska, Monika, additional, Dudziec, Beata, additional, and Nowicki, Marek, additional
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- 2023
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35. On the Mechanical Properties of Microfibre-Based 3D Chitinous Scaffolds from Selected Verongiida Sponges
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Duminis, Tomas, primary, Heljak, Marcin, additional, Święszkowski, Wojciech, additional, Ereskovsky, Alexander, additional, Dziedzic, Izabela, additional, Nowicki, Marek, additional, Pajewska-Szmyt, Martyna, additional, Voronkina, Alona, additional, Bornstein, Stefan R., additional, and Ehrlich, Hermann, additional
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- 2023
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36. Massively Parallel Sequence Alignment with BLAST Through Work Distribution Implemented Using PCJ Library
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Nowicki, Marek, Bzhalava, Davit, Bała, Piotr, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Ibrahim, Shadi, editor, Choo, Kim-Kwang Raymond, editor, Yan, Zheng, editor, and Pedrycz, Witold, editor
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- 2017
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37. Polydopamine grafted on an advanced Fe3O4/lignin hybrid material and its evaluation in biosensing
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Jędrzak, Artur, Rębiś, Tomasz, Nowicki, Marek, Synoradzki, Karol, Mrówczyński, Radosław, and Jesionowski, Teofil
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- 2018
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38. Comparisons of creatinine and cystatin C for detection of kidney disease and prediction of all-cause mortality in HIV-infected women
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Driver, Todd H, Scherzer, Rebecca, Peralta, Carmen A, Tien, Phyllis C, Estrella, Michelle M, Parikh, Chirag R, Butch, Anthony W, Anastos, Kathryn, Cohen, Mardge H, Nowicki, Marek, Sharma, Anjali, Young, Mary A, Abraham, Alison, and Shlipak, Michael G
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Biomedical and Clinical Sciences ,Clinical Sciences ,Infectious Diseases ,Kidney Disease ,Prevention ,Sexually Transmitted Infections ,HIV/AIDS ,Clinical Research ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Renal and urogenital ,Good Health and Well Being ,Adult ,Biomarkers ,Chronic Disease ,Cohort Studies ,Creatinine ,Cystatin C ,Female ,Glomerular Filtration Rate ,HIV Infections ,Humans ,Kidney Diseases ,Middle Aged ,Prognosis ,Survival Analysis ,creatinine ,cystatin C ,glomerular filtration rate ,HIV ,kidney ,mortality ,women ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundCystatin C could improve chronic kidney disease (CKD) classification in HIV-infected women relative to serum creatinine.DesignRetrospective cohort analysis.MethodsCystatin C and creatinine were measured from specimens taken and stored during the 1999-2000 examination among 908 HIV-infected participants in the Women's Interagency HIV study (WIHS). Mean follow-up was 10.2 years. Predictors of differential glomerular filtration rate (GFR) estimates were evaluated with multivariable linear regression. The associations of baseline categories (90 ml/min per 1.73 m) of creatinine estimated GFR (eGFRcr), cystatin C eGFR (eGFRcys), and combined creatinine-cystatin C eGFR (eGFRcr-cys) with all-cause mortality were evaluated using multivariable Cox regression. The net reclassification index (NRI) was calculated to evaluate the effect of cystatin C on reclassification of CKD staging.ResultsCKD risk factors were associated with lower eGFRcys and eGFRcr-cys values compared with eGFRcr. Relative to eGFR more than 90, the eGFR less than 60 category by eGFRcys (Adjusted hazard ratio: 2.56; 95% confidence interval: 1.63-4.02), eGFRcr-cys (3.11; 1.94-5.00), and eGFRcr (2.34; 1.44-3.79) was associated with increased mortality risk. However, the eGFR 60-90 category was associated with increased mortality risk for eGFRcys (1.80; 1.28-2.53) and eGFRcr-cys (1.91; 1.38-2.66) but not eGFRcr (1.20; 0.85-1.67). The overall NRI for mortality was 26% when reclassifying from eGFRcr to eGFRcys (P
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- 2013
39. Racial/Ethnic Differences in Spontaneous HCV Clearance in HIV Infected and Uninfected Women
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Sarkar, Monika, Bacchetti, Peter, Tien, Phyllis, Mileti, Elizabeth, French, Audrey L, Edlin, Brian R, Keller, Marla, Seaberg, Eric, Nowicki, Marek J, Young, Mary, and Peters, Marion G
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Medical Microbiology ,Biomedical and Clinical Sciences ,Hepatitis ,Pediatric AIDS ,Digestive Diseases ,Clinical Research ,Liver Disease ,Infectious Diseases ,HIV/AIDS ,Pediatric ,Drug Abuse (NIDA only) ,Hepatitis - C ,Substance Misuse ,Chronic Liver Disease and Cirrhosis ,Emerging Infectious Diseases ,Infection ,Good Health and Well Being ,Adult ,Black or African American ,Cross-Sectional Studies ,Female ,HIV Infections ,Hepatitis C ,Hispanic or Latino ,Humans ,Prospective Studies ,United States ,White People ,African American ,Hispanic ,Acute hepatitis C ,Clinical Sciences ,Gastroenterology & Hepatology ,Clinical sciences - Abstract
Background/aimsAmong individuals without human immunodeficiency virus (HIV), African Americans have lower spontaneous clearance of hepatitis C virus (HCV) than Caucasians, and women have higher clearance than men. Few studies report racial/ethnic differences in acute HCV in HIV infected, or Hispanic women. We examined racial/ethnic differences in spontaneous HCV clearance in a population of HCV mono- and co-infected women.MethodsWe conducted a cross sectional study of HCV seropositive women (897 HIV infected and 168 HIV uninfected) followed in the US multicenter, NIH-funded Women's Interagency HIV Study (WIHS), to determine the association of race/ethnicity with spontaneous HCV clearance, as defined by undetectable HCV RNA at study entry.ResultsAmong HIV and HCV seropositive women, 18.7 % were HCV RNA negative, 60.9 % were African American, 19.3 % Hispanic and 17.7 % Caucasian. HIV infected African American women were less likely to spontaneously clear HCV than Hispanic (OR 0.59, 95 % CI 0.38-0.93, p = 0.022) or Caucasian women (OR 0.57, 95 % CI 0.36-0.93, p = 0.023). Among HIV uninfected women, African Americans had less HCV clearance than Hispanics (OR 0.18, 95 % CI 0.07-0.48, p = 0.001) or Caucasians (OR 0.26, 95 % CI 0.09-0.79, p = 0.017). There were no significant differences in HCV clearance between Hispanics and Caucasians, among either HIV infected (OR 0.97, 95 % CI 0.57-1.66, p = 0.91) or uninfected (OR 1.45, 95 % CI 0.56-3.8, p = 0.45) women.ConclusionsAfrican Americans were less likely to spontaneously clear HCV than Hispanics or Caucasians, regardless of HIV status. No significant differences in spontaneous HCV clearance were observed between Caucasian and Hispanic women. Future studies incorporating IL28B genotype may further explain these observed racial/ethnic differences in spontaneous HCV clearance.
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- 2013
40. Association of Hepatitis C With Markers of Hemostasis In HIV-Infected and Uninfected Women in the Women's Interagency HIV Study (WIHS)
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Kiefer, Elizabeth M, Shi, Qiuhu, Hoover, Donald R, Kaplan, Robert, Tracy, Russell, Augenbraun, Michael, Liu, Chenglong, Nowicki, Marek, Tien, Phyllis C, Cohen, Mardge, Golub, Elizabeth T, and Anastos, Kathryn
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Chronic Liver Disease and Cirrhosis ,Infectious Diseases ,Clinical Research ,HIV/AIDS ,Digestive Diseases ,Hematology ,Liver Disease ,Hepatitis ,Emerging Infectious Diseases ,Hepatitis - C ,Infection ,Good Health and Well Being ,Adult ,Biomarkers ,Coinfection ,Cross-Sectional Studies ,Factor VIII ,Female ,Fibrin Fibrinogen Degradation Products ,HIV Infections ,Hemostasis ,Hepatitis C ,Humans ,Plasminogen Activator Inhibitor 1 ,Prospective Studies ,Protein S ,Regression Analysis ,United States ,hepatitis C ,HIV ,thrombosis ,coinfection ,coagulation ,Clinical Sciences ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
BackgroundCoinfection with HIV and hepatitis C virus (HCV) is common. HIV infection and treatment are associated with hypercoagulability; thrombosis in HCV is underinvestigated. Proposed markers of hemostasis in HIV include higher D-dimer, Factor VIII%, and plasminogen activator inhibitor-1 (PAI-1) antigen and lower total Protein S% (TPS) but have not been examined in HCV. We assessed the independent association of HCV with these 4 measures of hemostasis in a multicenter, prospective study of HIV: the Women's Interagency HIV Study.MethodsWe randomly selected 450 HCV-infected (anti-HCV+ with detectable plasma HCV RNA) and 450 HCV-uninfected (anti-HCV-) women. HCV was the main exposure of interest in regression models.ResultsFour hundred forty-three HCV+ and 425 HCV- women were included. HCV+ women had higher Factor VIII% (124.4% ± 3.9% vs. 101.8% ± 3.7%, P < 0.001) and lower TPS (75.7% ± 1.1% vs. 84.3% ± 1.1%,
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- 2013
41. Urinary Markers of Kidney Injury and Kidney Function Decline in HIV-Infected Women
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Shlipak, Michael G, Scherzer, Rebecca, Abraham, Alison, Tien, Phyllis C, Grunfeld, Carl, Peralta, Carmen A, Devarajan, Prasad, Bennett, Michael, Butch, Anthony W, Anastos, Kathryn, Cohen, Mardge H, Nowicki, Marek, Sharma, Anjali, Young, Mary A, Sarnak, Mark J, and Parikh, Chirag R
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Biomedical and Clinical Sciences ,Clinical Sciences ,Sexually Transmitted Infections ,HIV/AIDS ,Clinical Research ,Kidney Disease ,Infectious Diseases ,Renal and urogenital ,Good Health and Well Being ,AIDS-Associated Nephropathy ,Acute-Phase Proteins ,Adult ,Albuminuria ,Biomarkers ,Case-Control Studies ,Creatinine ,Disease Progression ,Female ,Glomerular Filtration Rate ,HIV Infections ,Hepatitis A Virus Cellular Receptor 1 ,Humans ,Interleukin-18 ,Kidney ,Lipocalin-2 ,Lipocalins ,Membrane Glycoproteins ,Middle Aged ,Proto-Oncogene Proteins ,Receptors ,Virus ,Risk Factors ,HIV ,KIM-1 ,NGAL ,IL-18 ,albumin-to-creatinine ratio ,cystatin C ,kidney injury ,Public Health and Health Services ,Virology ,Clinical sciences ,Epidemiology ,Public health - Abstract
ObjectiveHIV-infected persons have substantially higher risk of kidney failure than persons without HIV, but serum creatinine levels are insensitive for detecting declining kidney function. We hypothesized that urine markers of kidney injury would be associated with declining kidney function among HIV-infected women.MethodsIn the Women's Interagency HIV Study, we measured concentrations of albumin-to-creatinine ratio, interleukin-18 (IL-18), kidney injury marker-1 (KIM-1), and neutrophil gelatinase-associated lipocalin from stored urine among 908 HIV-infected and 289 HIV-uninfected participants. Primary analyses used cystatin C-based estimated glomerular filtration rate (CKD-EPI eGFRcys) as the outcome, measured at baseline and 2 follow-up visits over 8 years; secondary analyses used creatinine (CKD-EPI eGFRcr). Each urine biomarker was categorized into tertiles, and kidney decline was modeled with both continuous and dichotomized outcomes.ResultsCompared with the lowest tertiles, the highest tertiles of albumin-to-creatinine ratio (-0.15 mL/min per 1.73 m, P < 0.0001), IL-18 (-0.09 mL/min per 1.73 m, P < 0.0001) and KIM-1 (-0.06 mL/min per 1.73 m, P < 0.001) were independently associated with faster eGFRcys decline after multivariate adjustment including all 3 biomarkers among HIV-infected women. Among these biomarkers, only IL-18 was associated with each dichotomized eGFRcys outcome: ≥3% (relative risk = 1.40; 95% confidence interval: 1.04 to 1.89); ≥5% (1.88; 1.30 to 2.71); and ≥10% (2.16; 1.20 to 3.88) for the highest versus lowest tertile. In alternative models using eGFRcr, the high tertile of KIM-1 had independent associations with 5% (1.71; 1.25 to 2.33) and 10% (1.78; 1.07 to 2.96) decline, and the high IL-18 tertile with 10% decline (1.97; 1.00 to 3.87).ConclusionsAmong HIV-infected women in the Women's Interagency HIV Study cohort, novel urine markers of kidney injury detect risk for subsequent declines in kidney function.
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- 2012
42. Lower liver‐related death in African‐American women with human immunodeficiency virus/hepatitis C virus coinfection, compared to Caucasian and Hispanic women
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Sarkar, Monika, Bacchetti, Peter, French, Audrey L, Tien, Phyllis, Glesby, Marshall J, Nowicki, Marek, Plankey, Michael, Gange, Stephen, Sharp, Gerald, Minkoff, Howard, Peters, Marion G, and Study, for the Women's Interagency HIV
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Medical Microbiology ,Biomedical and Clinical Sciences ,Emerging Infectious Diseases ,HIV/AIDS ,Clinical Research ,Hepatitis ,Chronic Liver Disease and Cirrhosis ,Digestive Diseases ,Liver Disease ,Infectious Diseases ,Hepatitis - C ,Infection ,Good Health and Well Being ,Adult ,Black or African American ,CD4 Lymphocyte Count ,Coinfection ,Female ,HIV ,HIV Infections ,Hepacivirus ,Hepatitis C ,Hispanic or Latino ,Humans ,Liver Diseases ,Middle Aged ,Multivariate Analysis ,Prospective Studies ,RNA ,Viral ,United States ,White People ,Women's Interagency HIV Study ,Medical Biochemistry and Metabolomics ,Clinical Sciences ,Immunology ,Gastroenterology & Hepatology ,Clinical sciences - Abstract
UnlabelledAmong individuals with and without concurrent human immunodeficiency virus (HIV), racial/ethnic differences in the natural history of hepatitis C virus (HCV) have been described. African Americans have lower spontaneous HCV clearance than Caucasians, yet slower rates of liver fibrosis once chronically infected. It is not clear how these differences in the natural history of hepatitis C affect mortality, in either HIV-positive or -negative individuals. We conducted a cohort study of HIV/HCV coinfected women followed in the multicenter Women's Interagency HIV Study to determine the association of self-reported race/ethnicity with all-cause and liver-related mortality. Survival analyses were performed using Cox's proportional hazards models. The eligible cohort (n = 794) included 140 Caucasians, 159 Hispanics, and 495 African Americans. There were 438 deaths and 49 liver-related deaths during a median follow-up of 8.9 years and maximum follow-up of 16 years. African-American coinfected women had significantly lower liver-related mortality, compared to Caucasian (hazard ratio [HR], 0.41; 95% confidence interval [CI]: 0.19-0.88; P = 0.022) and Hispanic coinfected women (HR, 0.38; 95% CI: 0.19-0.76; P = 0.006). All-cause mortality was similar between racial/ethnic groups (HRs for all comparisons: 0.82-1.03; log-rank test: P = 0.8).ConclusionsAfrican-American coinfected women were much less likely to die from liver disease, as compared to Caucasians and Hispanics, independent of other causes of death. Future studies are needed to investigate the reasons for this marked racial/ethnic discrepancy in liver-related mortality.
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- 2012
43. Interleukin 10 Responses Are Associated With Sustained CD4 T-Cell Counts in Treated HIV Infection
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Villacres, Maria C, Kono, Naoko, Mack, Wendy J, Nowicki, Marek J, Anastos, Kathryn, Augenbraun, Michael, Liu, Chenglong, Landay, Alan, Greenblatt, Ruth M, Gange, Stephen J, and Levine, Alexandra M
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,HIV/AIDS ,Hepatitis ,Digestive Diseases ,Liver Disease ,Hepatitis - C ,Sexually Transmitted Infections ,Clinical Research ,Emerging Infectious Diseases ,Infectious Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Infection ,Inflammatory and immune system ,Good Health and Well Being ,Antiretroviral Therapy ,Highly Active ,CD4 Lymphocyte Count ,CD4-Positive T-Lymphocytes ,Female ,HIV Infections ,HIV-1 ,Hepacivirus ,Hepatitis C ,Chronic ,Humans ,Inflammation ,Interleukin-10 ,Linear Models ,Multivariate Analysis ,Prospective Studies ,RNA ,Viral ,Reverse Transcriptase Polymerase Chain Reaction ,Toll-Like Receptor 3 ,Toll-Like Receptor 4 ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundInflammation persists in treated human immunodeficiency virus (HIV) infection and may contribute to an increased risk for non-AIDS-related pathologies. We investigated the correlation of cytokine responses with changes in CD4 T-cell levels and coinfection with hepatitis C virus (HCV) during highly active antiretroviral treatment (HAART).MethodsA total of 383 participants in the Women's Interagency HIV Study (212 with HIV monoinfection, 56 with HCV monoinfection, and 115 with HIV/HCV coinfection) were studied. HIV-infected women had 200 CD4 T cells/μL; 98% were receiving HAART at baseline. Changes in CD4 T-cell count between baseline and 2-4 years later were calculated. Peripheral blood mononuclear cells (PBMCs) obtained at baseline were used to measure interleukin 1β (IL-1β), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor α (TNF-α) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation.ResultsUndetectable HIV RNA (
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- 2012
44. Comparison of sort algorithms in Hadoop and PCJ
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Nowicki, Marek
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- 2020
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45. Genital Herpes Evaluation by Quantitative TaqMan PCR: Correlating Single Detection and Quantity of HSV-2 DNA in Cervicovaginal Lavage Fluids with Cross-sectional and Longitudinal Clinical Data.
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Aumakhan, Bulbulgul, Hardick, Andrew, Quinn, Thomas C, Laeyendecker, Oliver, Gange, Stephen J, Beyrer, Chris, Cox, Christopher, Anastos, Kathryn, Cohen, Mardge, Greenblatt, Ruth M, Merenstein, Daniel J, Minkoff, Howard, Nowicki, Marek, and Gaydos, Charlotte A
- Abstract
Abstract Objective To evaluate the utility of a single quantitative PCR (qPCR) measurement of HSV (HSV-1&2) DNA in cervicovaginal lavage (CVL) specimens collected from women with predominantly chronic HSV-2 infection in assessing genital HSV shedding and the clinical course of genital herpes (GH) within a cohort with semiannual schedule of follow up and collection of specimens. Methods Two previously described methods used for detection of HSV DNA in mucocutaneous swab samples were adapted for quantification of HSV DNA in CVLs. Single CVL specimens from 509 women were tested. Presence and quantity of CVL HSV DNA were explored in relation to observed cross-sectional and longitudinal clinical data. Results The PCR assay was sensitive and reproducible with a limit of quantification of ~50 copies per milliliter of CVL. Overall, 7% of the samples were positive for HSV-2 DNA with median log10 HSV-2 DNA copy number of 3.9 (IQR: 2.6-5.7). No HSV-1 was detected. Presence and quantity of HSV-2 DNA in CVL directly correlated with the clinical signs and symptoms of presence of active symptomatic disease with frequent recurrences. Conclusion Single qPCR measurement of HSV DNA in CVL fluids of women with chronic HSV-2 infection provided useful information for assessing GH in the setting of infrequent sampling of specimens. Observed positive correlation of the presence and quantity of HSV-2 DNA with the presence of active and more severe course of HSV-2 infection may have clinical significance in the evaluation and management of HSV-2 infected patients.
- Published
- 2010
46. Clinical reactivations of herpes simplex virus type 2 infection and human immunodeficiency virus disease progression markers.
- Author
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Aumakhan, Bulbulgul, Gaydos, Charlotte A, Quinn, Thomas C, Beyrer, Chris, Benning, Lorie, Minkoff, Howard, Merenstein, Daniel J, Cohen, Mardge, Greenblatt, Ruth, Nowicki, Marek, Anastos, Kathryn, and Gange, Stephen J
- Subjects
Humans ,Herpesvirus 2 ,Human ,Herpes Genitalis ,HIV Infections ,Disease Progression ,RNA ,Viral ,CD4 Lymphocyte Count ,Longitudinal Studies ,Virus Activation ,Adult ,Female ,Biomarkers ,Herpesvirus 2 ,Human ,RNA ,Viral ,General Science & Technology - Abstract
BackgroundThe natural history of HSV-2 infection and role of HSV-2 reactivations in HIV disease progression are unclear.MethodsClinical symptoms of active HSV-2 infection were used to classify 1,938 HIV/HSV-2 co-infected participants of the Women's Interagency HIV Study (WIHS) into groups of varying degree of HSV-2 clinical activity. Differences in plasma HIV RNA and CD4+ T cell counts between groups were explored longitudinally across three study visits and cross-sectionally at the last study visit.ResultsA dose dependent association between markers of HIV disease progression and degree of HSV-2 clinical activity was observed. In multivariate analyses after adjusting for baseline CD4+ T cell levels, active HSV-2 infection with frequent symptomatic reactivations was associated with 21% to 32% increase in the probability of detectable plasma HIV RNA (trend p = 0.004), an average of 0.27 to 0.29 log10 copies/ml higher plasma HIV RNA on a continuous scale (trend p
- Published
- 2010
47. Precipitation of Pt, Pd, Rh, and Ru Nanoparticles with Non-Precious Metals from Model and Real Multicomponent Solutions
- Author
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Rzelewska-Piekut, Martyna, primary, Wolańczyk, Zuzanna, additional, Nowicki, Marek, additional, and Regel-Rosocka, Magdalena, additional
- Published
- 2023
- Full Text
- View/download PDF
48. The Performance Evaluation of the Java Implementation of Graph500
- Author
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Ryczkowska, Magdalena, Nowicki, Marek, Bala, Piotr, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Wyrzykowski, Roman, editor, Deelman, Ewa, editor, Dongarra, Jack, editor, Karczewski, Konrad, editor, Kitowski, Jacek, editor, and Wiatr, Kazimierz, editor
- Published
- 2016
- Full Text
- View/download PDF
49. Electrochemical polymerization of pyrrole on Au(111) in sulphuric acid and sodium hexafluoroaluminate solutions monitored by electrochemical scanning tunneling microscopy
- Author
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Madry, Bartosz, Grzeszczuk, Maria, Wandelt, Klaus, and Nowicki, Marek
- Published
- 2017
- Full Text
- View/download PDF
50. On-line Service for Teaching Parallel Programming
- Author
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Nowicki, Marek, Marchwiany, Maciej, Szpindler, Maciej, Bała, Piotr, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Hunold, Sascha, editor, Costan, Alexandru, editor, Giménez, Domingo, editor, Iosup, Alexandru, editor, Ricci, Laura, editor, Gómez Requena, María Engracia, editor, Scarano, Vittorio, editor, Varbanescu, Ana Lucia, editor, Scott, Stephen L., editor, Lankes, Stefan, editor, Weidendorfer, Josef, editor, and Alexander, Michael, editor
- Published
- 2015
- Full Text
- View/download PDF
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