Search

Your search keyword '"Nowicka, Anna M."' showing total 347 results
Start Over Author "Nowicka, Anna M."
347 results on '"Nowicka, Anna M."'

2. Lack of cytotoxic and genotoxic effects of mPEG-silane coated iron(III) oxide nanoparticles doped with magnesium despite cellular uptake in cancerous and noncancerous lung cells

Author

Sikorska, Malgorzata, Ruzycka-Ayoush, Monika, Rios-Mondragon, Ivan, Longhin, Eleonora Marta, Meczynska-Wielgosz, Sylwia, Wojewodzka, Maria, Kowalczyk, Agata, Kasprzak, Artur, Nowakowska, Julita, Sobczak, Kamil, Muszynska, Magdalena, Cimpan, Mihaela Roxana, Runden-Pran, Elise, Shaposhnikov, Sergey, Kruszewski, Marcin, Dusinska, Maria, Nowicka, Anna M., and Grudzinski, Ireneusz P.

Published
2024
Full Text
View/download PDF

21. Oxidation-derived anticancer potential of sumanene–ferrocene conjugates.

Author

Kasprzak, Artur, Zuchowska, Agnieszka, Romanczuk, Pawel, Kowalczyk, Agata, Grudzinski, Ireneusz P., Malkowska, Anna, Nowicka, Anna M., and Sakurai, Hidehiro

Subjects
CHROMOSOME abnormalities, AMES test, REACTIVE oxygen species, CANCER cells, CYTOTOXINS, FERROCENE
Abstract

An effective synthetic protocol towards the oxidation of sumanene–ferrocene conjugates bearing one to four ferrocene moieties has been established. The oxidation protocol was based on the transformation of FeII from ferrocene to FeIII-containing ferrocenium cations by means of the treatment of the title organometallic buckybowls with a mild oxidant. Successful isolation of these ferrocenium-tethered sumanene derivatives 5–7 gave rise to the biological evaluation of the first, buckybowl-based anticancer agents, as elucidated by in vitro assays with human breast adenocarcinoma cells (MDA-MB-231) and embryotoxicity trials in zebrafish embryos supported with in silico toxicology studies. The designed ferrocenium-tethered sumanene derivatives featured attractive properties in terms of their use in cancer treatments in humans. The tetra-ferrocenium sumanene derivative 7 featured especially beneficial biological features, elucidated by low (<40% for 10 μM) viabilities of MDA-MB-231 cancer cells together with a 1.4–1.7-fold higher viability of normal cells (human mammary fibroblasts, HMF) for respective concentrations. Compound 7 featured significant cytotoxicity against cancer cells thanks to the presence of sumanene and ferrocenium moieties; the latter motif also provided the selectivity of anticancer action. The biological properties of 7 were also improved in comparison with those of native building blocks, which suggested the effects of the presence of the sumanene skeleton towards the anticancer action of this molecule. Ferrocenium-tethered sumanene derivatives exhibited potential towards the generation of reactive oxygen species (ROS), responsible for biological damage to the cancer cells, with the most efficient generation of the tetra-ferrocenium sumanene derivative 7. Derivative 7 also did not show any embryotoxicity in zebrafish embryos at the tested concentrations, which supports its potential as an effective and cancer-specific anticancer agent. In silico computational analysis also showed no chromosomal aberrations and no mutation with AMES tests for the compound 7 tested with and without microsomal rat liver fractions, which supports its further use as a potent drug candidate in detailed anticancer studies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Supplementary Figure S2 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Author

Ruf, Melanie, primary, Mittmann, Christiane, primary, Nowicka, Anna M., primary, Hartmann, Arndt, primary, Hermanns, Thomas, primary, Poyet, Cédric, primary, van den Broek, Maries, primary, Sulser, Tullio, primary, Moch, Holger, primary, and Schraml, Peter, primary

Published
2023
Full Text
View/download PDF

30. Supplementary Tables S1-S4 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

Author

Ruf, Melanie, primary, Mittmann, Christiane, primary, Nowicka, Anna M., primary, Hartmann, Arndt, primary, Hermanns, Thomas, primary, Poyet, Cédric, primary, van den Broek, Maries, primary, Sulser, Tullio, primary, Moch, Holger, primary, and Schraml, Peter, primary

Published
2023
Full Text
View/download PDF

35. Synthesis of π-extended and bowl-shaped sumanene–ferrocene conjugates and their application in highly selective and sensitive cesium cations electrochemical sensors

Author

Cyniak, Jakub S., primary, Kocobolska, Łucja, additional, Bojdecka, Natalia, additional, Gajda-Walczak, Aleksandra, additional, Kowalczyk, Agata, additional, Wagner, Barbara, additional, Nowicka, Anna M., additional, Sakurai, Hidehiro, additional, and Kasprzak, Artur, additional

Published
2023
Full Text
View/download PDF

42. Parallel SPR and QCM‑D Quantitative Analysis of CD9, CD63, and CD81 Tetraspanins: A Simple and Sensitive Way to Determine the Concentration of Extracellular Vesicles Isolated from Human Lung Cancer Cells.

Author

Kowalczyk, Agata, Gajda-Walczak, Aleksandra, Ruzycka-Ayoush, Monika, Targonska, Alicja, Mosieniak, Grazyna, Glogowski, Maciej, Szumera-Cieckiewicz, Anna, Prochorec-Sobieszek, Monika, Bamburowicz-Klimkowska, Magdalena, Nowicka, Anna M., and Grudzinski, Ireneusz P.

Published
2023
Full Text
View/download PDF

43. Application of biocompatible and ultrastable superparamagnetic iron(III) oxide nanoparticles doped with magnesium for efficient magnetic fluid hyperthermia in lung cancer cells.

Author

Nowicka, Anna M., Ruzycka-Ayoush, Monika, Kasprzak, Artur, Kowalczyk, Agata, Bamburowicz-Klimkowska, Magdalena, Sikorska, Malgorzata, Sobczak, Kamil, Donten, Mikolaj, Ruszczynska, Anna, Nowakowska, Julita, and Grudzinski, Ireneusz P.

Abstract

Magnetic fluid hyperthermia (MFH) is a promising therapeutic strategy that targets malignant tissues by heating to 40–43 °C using magnetic nanoparticles (MNPs) subjected to an alternating magnetic field (AMF). In this study, novel magnetic iron(III) oxide nanoparticles doped with magnesium (Mg0.1-γ-Fe2O3(mPEG-silane)0.5) were synthesized, and their structural, chemical, and magnetic properties were analyzed using the following techniques: Fourier-transform infrared spectroscopy, Raman spectroscopy, vibrating magnetometer analysis, powder X-ray diffraction, inductively coupled plasma mass spectrometry, scanning electron microscopy, high-resolution transmission electron microscopy, and energy-dispersive X-ray spectroscopy. The as-synthesized MNPs were used as water ferrofluids for MFH under an AMF in two calorimetric setups, namely phantom and lung cancer cell (A549) models. The as-synthesized MNPs were hexagonal or rhombohedral shaped, with an average size of 27 nm. They showed a typical soft ferromagnetic behavior based on the hysteresis profile, with a magnetic saturation of 70 emu g−1 and remnant magnetization of 1.6 emu g−1. In phantom studies, the ferrofluid (3.0 mg mL−1) exposed to an AMF (18.3 kA m−1, 110.1 kHz) heated up extremely quickly, reaching more than 90 °C in the first 10 min of magnetization. In cell studies, the ferrofluid (0.25 mg mL−1) under an AMF (16.7 kA m−1, 110.1 kHz) showed a slight increase in temperature within the first 12 min, reaching a peak of ca. 43–45 °C, which was stable up to the end of the AMF exposure (45 min). Under these conditions, a pronounced cytotoxic effect on the lung cancer cells was observed (viability ca. 15–20%). No such deleterious effects were observed when the cells were treated with MNPs only without an AMF. Specific absorption rate (SAR) measurements were performed using three mathematical approaches, namely the initial slope method, the corrected slope method, and the Box–Lucas method, which ranged from ca. 429 to 596 W g−1 for phantom and cell studies. Iron(III) oxide MNPs doped with magnesium were found to be candidates for MFH in lung cancer treatments. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results