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8 results on '"Nowakowski, Alexander"'

1. Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes.

Author

Dankner, Matthew, Maritan, Sarah M, Priego, Neibla, Kruck, Georgia, Nkili-Meyong, Andriniaina, Nadaf, Javad, Zhuang, Rebecca, Annis, Matthew G, Zuo, Dongmei, Nowakowski, Alexander, Biondini, Marco, Kiepas, Alexander, Mourcos, Caitlyn, Le, Phuong, Charron, François, Inglebert, Yanis, Savage, Paul, Théret, Louis, Guiot, Marie-Christine, and McKinney, R Anne

Published
2024
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4. Cell migration capacity alone can be hereditary and predict metastatic burden

Author

Desjardins-Lecavalier, Nicolas, primary, Annis, Matthew G., additional, Nowakowski, Alexander, additional, Kiepas, Alexander, additional, Binan, Loic, additional, Roy, Joannie, additional, Modica, Graziana, additional, Hebert, Steven, additional, Kleinman, Claudia L., additional, Siegel, Peter M., additional, and Costantino, Santiago, additional

Published
2023
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5. Abstract 1569: pSTAT3+ stromal cells drive the invasive growth of brain metastases

Author

Dankner, Matthew, primary, Maritan, Sarah M., additional, Priego, Neibla, additional, Nadaf, Javad, additional, Nkili, Andy, additional, Zhuang, Rebecca, additional, Kruck, Georgia, additional, Zuo, Dongmei, additional, Nowakowski, Alexander, additional, Inglebert, Yanis, additional, Savage, Paul, additional, Park, Morag, additional, Guiot, Marie-Christine, additional, McKinney, Anne, additional, Muller, William J., additional, Valiente, Manuel, additional, Petrecca, Kevin, additional, and Siegel, Peter M., additional

Published
2022
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7. Clinical activity of mitogen-activated protein kinase (MAPK) inhibitors in patients with MAP2K1 (MEK1)-mutated metastatic cancers: A systematic review and meta-analysis.

Author

Dankner, Matthew, Petrecca, Sarah, Fabi, Francois, Nowakowski, Alexander, Rajadurai, Charles Vincent, Rousselle, Emmanuelle, Stein, Andrew, Bian, David Jiahua, Tai, Peter, Belaiche, Alicia, Li, Meredith, Lazaratos, Anna-Maria, Quaiattini, Andrea, Normanno, Nicola, Arcila, Maria E., Elkrief, Arielle, Ladanyi, Marc, and Rose, April A. N.

Published
2023
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8. Mitochondrial elongation impairs breast cancer metastasis.

Author

Minarrieta, Lucía, Annis, Matthew G., Audet-Delage, Yannick, Kuasne, Hellen, Pacis, Alain, St-Louis, Catherine, Nowakowski, Alexander, Biondini, Marco, Khacho, Mireille, Park, Morag, Siegel, Peter M., and St-Pierre, Julie

Subjects
*METASTATIC breast cancer, *MITOCHONDRIAL dynamics, *CELL physiology, *MITOCHONDRIA, *TREATMENT effectiveness, *BREAST
Abstract

Mitochondrial dynamics orchestrate many essential cellular functions, including metabolism, which is instrumental in promoting cancer growth and metastatic progression. However, how mitochondrial dynamics influences metastatic progression remains poorly understood. Here, we show that breast cancer cells with low metastatic potential exhibit a more fused mitochondrial network compared to highly metastatic cells. To study the impact of mitochondrial dynamics on metastasis, we promoted mitochondrial elongation in metastatic breast cancer cells by individual genetic deletion of three key regulators of mitochondrial fission (Drp1, Fis1, Mff) or by pharmacological intervention with leflunomide. Omics analyses revealed that mitochondrial elongation causes substantial alterations in metabolic pathways and processes related to cell adhesion. In vivo, enhanced mitochondrial elongation by loss of mitochondrial fission mediators or treatment with leflunomide notably reduced metastasis formation. Furthermore, the transcriptomic signature associated with elongated mitochondria correlated with improved clinical outcome in patients with breast cancer. Overall, our findings highlight mitochondrial dynamics as a potential therapeutic target in breast cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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