Search

Your search keyword '"Nowakowska, Dominika"' showing total 124 results
Start Over Author "Nowakowska, Dominika"
124 results on '"Nowakowska, Dominika"'

1. Can Corporate Social Responsibility Shift Consumer Behavior? Insights from Scenario-Based Experiment in the Fast Fashion Industry.

Author

Zaborek, Piotr and Nowakowska, Dominika

Subjects
CONSUMER behavior, SUSTAINABLE consumption, SOCIAL responsibility of business, EXTRINSIC motivation, FAST fashion, CONSUMER ethics
Abstract

This study investigates the interplay between Corporate Social Responsibility (CSR) engagement and pricing strategies in shaping consumer purchase intentions in the fast fashion industry. Using a scenario-based experimental design with 267 participants, this research explores how different levels of CSR and two distinct price points influence purchasing behavior. Additionally, the moderating effects of individual differences, such as consumer wealth, motivations for sustainable behavior, and income, are examined. The findings indicate that higher levels of CSR engagement significantly enhance purchase intentions, particularly when combined with higher price points, perhaps due to consumer perceptions of CSR programs associated with more expensive brands as more authentic. However, price remains a critical factor for lower-income consumers, revealing an "ethical consumption gap" where affordability outweighs ethical concerns. Extrinsic motivations, such as social pressure, strongly influence wealthier consumers' decisions, while intrinsic motivations show a more complex relationship with purchasing behavior. The findings provide practical insights for fast fashion brands, suggesting that aligning CSR with competitive pricing and authentic messaging is crucial for appealing to both price-sensitive and ethically conscious consumers. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor Growth.

Author

Novobrantseva, Tatiana, Manfra, Denise, Ritter, Jessica, Razlog, Maja, O'Nuallain, Brian, Zafari, Mohammad, Nowakowska, Dominika, Basinski, Sara, Phennicie, Ryan T., Nguyen, Phuong A., Brehm, Michael A., Sazinsky, Stephen, and Feldman, Igor

Subjects
RNA metabolism, CLINICAL drug trials, SMALL interfering RNA, LIGANDS (Biochemistry), RESEARCH funding, T cells, MACROPHAGES, ANTINEOPLASTIC agents, INVESTIGATIONAL drugs, CELL physiology, IMMUNOTHERAPY, IMMUNOGLOBULINS, GLYCOPROTEINS, MONOCLONAL antibodies, CELL lines, IMMUNE checkpoint inhibitors, GENE expression, DRUG efficacy, DRUG development, TUMORS, INFLAMMATION, BIOMARKERS, SEQUENCE analysis, PHARMACODYNAMICS
Abstract

Simple Summary: Cancer can create a shield of suppressive innate immune cells that stop our body's natural defenses from tumors. VTX-0811 is a new drug that targets these cells and turns them from allies of cancer to fighters against it. Preclinical tests show that it works in the lab on human cells and tumors and is safe and efficacious in animals. The results are promising and pave the way for human trials to see if VTX-0811 can become a new powerful weapon against cancer. Omnipresent suppressive myeloid populations in the tumor microenvironment limit the efficacy of T-cell-directed immunotherapies, become more inhibitory after administration of T-cell checkpoint inhibitors, and are overall associated with worse survival of cancer patients. In early clinical trials, positive outcomes have been demonstrated for therapies aimed at repolarizing suppressive myeloid populations in the tumor microenvironment. We have previously described the key role of P-selectin glycoprotein ligand-1 (PSGL-1) in maintaining an inhibitory state of tumor-associated macrophages (TAMs), most of which express high levels of PSGL-1. Here we describe a novel, first-in-class humanized high-affinity monoclonal antibody VTX-0811 that repolarizes human macrophages from an M2-suppressive phenotype towards an M1 inflammatory phenotype, similar to siRNA-mediated knockdown of PSGL-1. VTX-0811 binds to PSGL-1 of human and cynomolgus macaque origins without inhibiting PSGL-1 interaction with P- and L-Selectins or VISTA. In multi-cellular assays and in patient-derived human tumor cultures, VTX-0811 leads to the induction of pro-inflammatory mediators. RNAseq data from VTX-0811 treated ex vivo tumor cultures and M2c macrophages show similar pathways being modulated, indicating that the mechanism of action translates from isolated macrophages to tumors. A chimeric version of VTX-0811, consisting of the parental murine antibody in a human IgG4 backbone, inhibits tumor growth in a humanized mouse model of cancer. VTX-0811 is exceptionally well tolerated in NHP toxicology assessment and is heading into clinical evaluation after successful IND clearance. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Phenotype and function of regulatory T cells in Th1- and Th2-mediated inflammatory diseases

Author

Nowakowska, Dominika Joanna, Anderton, Stephen, and O'Connor, Richard

Subjects
616.97, autoimmunity, allergic airways inflammation, regulatory T cells
Abstract

Regulatory T cells (Treg) are critical to the maintenance of immune tolerance, partly by controlling the unwanted activation of effector T cells (Teff) and thereby enhancing the resolution of autoimmune and allergic inflammation. Recent data suggest that Treg can specialize to better control different types of inflammation by using transcriptional machinery which controls differentiation and function of Teff. This thesis addresses questions related to the efficacious use of Treg, notably their ability to adopt distinct phenotypic profiles under different inflammatory contexts and their need to recognize antigen in the inflamed organ. Two differentially mediated mouse disease models were used in this project, namely Th1/Th17-mediated experimental autoimmune encephalomyelitis (EAE) as a model of multiple sclerosis and Th2-mediated allergic airways inflammation (AAI) as a model of asthma. A new model of rMOG-induced AAI was developed to specifically answer the questions on the importance of cell phenotype versus antigen-reactivity for the effective Treg-mediated suppression. It was demonstrated that Treg from the inflamed CNS in EAE had an upregulated expression of Th1 master regulator T-bet and Th1-associated chemokine receptor CXCR3, whereas Treg derived from the inflamed lung in AAI had an increased expression of Th2 master regulator GATA-3, lacked expression of T-bet and displayed decreased levels of CXCR3. This specialized and activated phenotype was restricted to tissue-derived Treg. The importance of appropriate Treg phenotype for effective suppression was suggested by the observed inability of CNS-derived Treg to inhibit AAI. A different Treg subset, TGF-β-induced Treg (iTreg), was shown to express high levels of T-bet and CXCR3, but not GATA-3 upon induction in vitro. iTreg effectively suppressed both Th1 and Th2 types of inflammation and the antigenreactivity was key to this. This thesis demonstrates that Treg are capable of acquiring a distinct phenotype corresponding with a CD4+ T cell response driving inflammatory disease and identifies antigen-reactivity as key to the efficacious suppression of inflammation. It also highlights substantial phenotypic differences between iTreg and naturally-occurring Treg which could be associated with different modes of suppression.

Published
2013

5. Supplementary Figure 1 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

6. FIGURE 3 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

7. FIGURE 2 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

8. Supplementary Table 3 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

9. FIGURE 5 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

10. Supplementary Figure 9 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

11. FIGURE 6 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

12. Supplementary Table 1 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Figure 2 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figure 4 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Figure 6 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figure 5 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Figure 7 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

18. Supplementary Figure 3 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Table 2 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 8 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

21. FIGURE 4 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

22. FIGURE 1 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, primary, Nowakowska, Dominika, primary, Zafari, Mohammad, primary, Nguyen, Phuong A., primary, Phennicie, Ryan, primary, Vollmann, Elisabeth H., primary, O'Nuallain, Brian, primary, Basinski, Sara, primary, Komoroski, Veronica, primary, Rooney, Kate, primary, Culyba, Elizabeth K., primary, Wahle, Joseph, primary, Ries, Carola, primary, Brehm, Michael, primary, Sazinsky, Steve, primary, Feldman, Igor, primary, and Novobrantseva, Tatiana I., primary

Published
2023
Full Text
View/download PDF

23. PSGL-1 Blockade Induces Classical Activation of Human Tumor-Associated Macrophages

Author

Kauffman, Kevin, primary, Manfra, Denise, additional, Nowakowska, Dominika, additional, Zafari, Mohammad, additional, Nguyen, Phuong A, additional, Phennicie, Ryan, additional, Vollmann, Elisabeth H, additional, O'Nuallain, Brian, additional, Basinski, Sara, additional, Komoroski, Veronica, additional, Rooney, Kate, additional, Culyba, Elizabeth K, additional, Wahle, Joseph, additional, Ries, Carola, additional, Brehm, Michael, additional, Sazinsky, Stephen, additional, Feldman, Igor, additional, and Novobrantseva, Tatiana I., additional

Published
2023
Full Text
View/download PDF

24. Impact of revascularization in patients with sustained ventricular arrhythmias, prior myocardial infarction, and preserved left ventricular ejection fraction

Author

Mondésert, Blandine, Khairy, Paul, Schram, Gernot, Shohoudi, Azadeh, Talajic, Mario, Andrade, Jason G., Dubuc, Marc, Guerra, Peter G., Macle, Laurent, Roy, Denis, Dyrda, Katia, Thibault, Bernard, Barrero, Miguel, Diaz, Ariel, Kouz, Simon, McNicoll, Serge, Nowakowska, Dominika, and Rivard, Léna

Published
2016
Full Text
View/download PDF

27. Zastosowanie rekombinowanego aktywowanego czynnika VII w przypadkach krwotoku poporodowego i atonii macicy.

Author

Radoń-Pokracka, Małgorzata and Nowakowska, Dominika

Abstract

Copyright of Ginekologia i Perinatologia Praktyczna is the property of VM Medica-VM Group (Via Medica) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023

29. Abstract P107: PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Author

Nguyen, Ani, primary, Ritter, Jessica, additional, Zafari, Mohammad, additional, Manfra, Denise, additional, Komoroski, Veronica, additional, O'Nuallain, Brian, additional, Phennicie, Ryan, additional, Kauffman, Kevin, additional, Nowakowska, Dominika, additional, Wahle, Joe, additional, Sazinsky, Steve, additional, Brehm, Michael, additional, Feldman, Igor, additional, and Novobrantseva, Tatiana, additional

Published
2021
Full Text
View/download PDF

30. 877 PSGL-1 blocking antibodies repolarize tumor associated macrophages, reduce suppressive myeloid populations and induce inflammation in the tumor microenvironment, leading to suppression of tumor growth

Author

Nguyen, Phuong, primary, Ritter, Jessica, additional, Zafari, Mohammad, additional, Manfra, Denise, additional, Komoroski, Veronica, additional, O’Nuallain, Brian, additional, Phennicie, Ryan, additional, Kauffman, Kevin, additional, Nowakowska, Dominika, additional, Wahle, Joe, additional, Sazinsky, Steve, additional, Brehm, Michael, additional, Feldman, Igor, additional, and Novobrantseva, Tatiana, additional

Published
2021
Full Text
View/download PDF

31. Acute retinal pigment epithelitis in a 11-year-old child: case presentation and follow-up using optical coherence tomography angiography and static visual field.

Author

Hamdan, Paweł, Piekuta-Hamdan, Magdalena, Nowakowska, Dominika, Kowalczyk, Małgorzata, Nowomiejska, Katarzyna, and Rejdak, Robert

Subjects
EPITHELIAL cells, NONSTEROIDAL anti-inflammatory agents, VISION disorders, RETINITIS pigmentosa, OPTICAL coherence tomography, REHABILITATION of blind people, VISUAL fields, VISUAL acuity
Abstract

We present a case of unilateral self-limiting acute retinal pigment epithelitis (ARPE) in an 11-year-old girl and 10 weeks of follow-up until complete recovery using spectral domain optical coherence tomography (SD-OCT), SD-OCT-angiography (SD-OCTA) and static visual field. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma

Author

Fiedorowicz, Michal; https://orcid.org/0000-0001-5755-3608, Choragiewicz, Tomasz, Turski, Waldemar A; https://orcid.org/0000-0002-5805-5106, Kocki, Tomasz, Nowakowska, Dominika; https://orcid.org/0000-0002-1200-563X, Wertejuk, Kamila, Kamińska, Agnieszka, Avitabile, Teresio, Wełniak-Kaminska, Marlena, Grieb, Pawel; https://orcid.org/0000-0002-6983-7947, Zweifel, Sandrine, Rejdak, Robert; https://orcid.org/0000-0003-3321-2723, Toro, Mario Damiano; https://orcid.org/0000-0001-7152-2613, Fiedorowicz, Michal; https://orcid.org/0000-0001-5755-3608, Choragiewicz, Tomasz, Turski, Waldemar A; https://orcid.org/0000-0002-5805-5106, Kocki, Tomasz, Nowakowska, Dominika; https://orcid.org/0000-0002-1200-563X, Wertejuk, Kamila, Kamińska, Agnieszka, Avitabile, Teresio, Wełniak-Kaminska, Marlena, Grieb, Pawel; https://orcid.org/0000-0002-6983-7947, Zweifel, Sandrine, Rejdak, Robert; https://orcid.org/0000-0003-3321-2723, and Toro, Mario Damiano; https://orcid.org/0000-0001-7152-2613

Abstract

BACKGROUND It has been shown that a possible pathogenetic mechanism of neurodegeneration in the mouse model of glaucoma (DBA/2J) may be an alteration of kynurenic acid (KYNA) in the retina. This study aimed to verify the hypothesis that alterations of tryptophan (TRP) metabolism in DBA/2J mice is not limited to the retina. METHODS Samples of the retinal tissue and serum were collected from DBA/2J mice (6 and 10 months old) and control C57Bl/6 mice of the same age. The concentration of TRP, KYNA, kynurenine (KYN), and 3-hydroxykynurenine (3OH-K) was measured by HPLC. The activity of indoleamine 2,3-dioxygenase (IDO) was also determined as a KYN/TRP ratio. RESULTS TRP, KYNA, L-KYN, and 3OH-K concentration were significantly lower in the retinas of DBA/2J mice than in C57Bl/6 mice. 3OH-K concentration was higher in older mice in both strains. Serum TRP, L-KYN, and KYNA concentrations were lower in DBA/2J than in age-matched controls. However, serum IDO activity did not differ significantly between compared groups and strains. CONCLUSIONS Alterations of the TRP pathway seem not to be limited to the retina in the murine model of hereditary glaucoma.

Published
2021

37. Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma

Author

Fiedorowicz, Michal, primary, Choragiewicz, Tomasz, additional, Turski, Waldemar A., additional, Kocki, Tomasz, additional, Nowakowska, Dominika, additional, Wertejuk, Kamila, additional, Kamińska, Agnieszka, additional, Avitabile, Teresio, additional, Wełniak-Kaminska, Marlena, additional, Grieb, Pawel, additional, Zweifel, Sandrine, additional, Rejdak, Robert, additional, and Toro, Mario Damiano, additional

Published
2021
Full Text
View/download PDF

39. 862 Targeting PSGL-1, a novel macrophage checkpoint, repolarizes suppressive macrophages, induces an inflammatory tumor microenvironment, and suppresses tumor growth

Author

Nguyen, Phuong, primary, Phennicie, Ryan, additional, Kauffman, Kevin, additional, Nowakowska, Dominika, additional, Zafari, Mohammad, additional, Komoroski, Veronica, additional, Sazinsky, Steve, additional, Wahle, Joe, additional, Manfra, Denise, additional, Vaidya, Shantashri, additional, Brehm, Michael, additional, Feldman, Igor, additional, and Novobrantseva, Tatiana, additional

Published
2020
Full Text
View/download PDF

41. PSGL-1 is a novel macrophage checkpoint in immuno-oncology.

Author

Nowakowska, Dominika, primary, Phennicie, Ryan, additional, Kauffman, Kevin, additional, Zafari, Mohammad, additional, Rooney, Kathryn, additional, O’Nuallain, Brian, additional, Sazinsky, Steve, additional, Wahle, Joe, additional, Feldman, Igor, additional, and Novobrantseva, Tatiana, additional

Published
2020
Full Text
View/download PDF

46. Tryptophan and Kynurenine Pathway Metabolites in Animal Models of Retinal and Optic Nerve Damage: Different Dynamics of Changes

Author

Fiedorowicz, Michal, primary, Choragiewicz, Tomasz, additional, Thaler, Sebastian, additional, Schuettauf, Frank, additional, Nowakowska, Dominika, additional, Wojtunik, Kamila, additional, Reibaldi, Michele, additional, Avitabile, Teresio, additional, Kocki, Tomasz, additional, Turski, Waldemar A., additional, Kaminska, Agnieszka, additional, Grieb, Pawel, additional, Zrenner, Eberhart, additional, Rejdak, Robert, additional, and Toro, Mario Damiano, additional

Published
2019
Full Text
View/download PDF

49. Central retinal artery occlusion (CRAO)- case report

Author

Jędrzej Tkaczyk, Brożyna, Klaudia, Baltaziak, Katarzyna, Ciechański, Krystian, Nowakowska, Dominika, and Rejdak, Robert

Subjects
lcsh:Sports, ophthalmology, lcsh:GV557-1198.995, genetic structures, crao, lcsh:R, lcsh:Medicine, occlusion, lcsh:L, eye diseases, lcsh:Education
Abstract

Tkaczyk Jędrzej, Brożyna Klaudia, Baltaziak Katarzyna, Ciechański Krystian, Nowakowska Dominika, Rejdak Robert. Central retinal artery occlusion (CRAO)- case report. Journal of Education, Health and Sport. 2018;8(9):359-366. eISNN 2391-8306. DOI http://dx.doi.org/10.6084/m9.figshare.6990896 http://ojs.ukw.edu.pl/index.php/johs/article/view/5846 Central retinal artery occlusion (CRAO)- case report Jędrzej Tkaczyk1, Klaudia Brożyna1, Katarzyna Baltaziak2, Krystian Ciechański1, Dominika Nowakowska3, Robert Rejdak3 1 Student’s research group at the Clinical Department of Vascular Surgery and Angiology, Medical University of Lublin 2 Student’s research group at the Clinical Department of Ophthalmology, Medical University of Lublin 3 Clinical Department of General Ophthalmology, Medical University of Lublin Corresponding author: Jędrzej Tkaczyk, e-mail: jedrzej.tkaczyk@gmail.com Abstract: Central retinal artery occlusion (CRAO) is an ophthalmic emergency, most commonly caused by an embolism, usually from the carotid arteries. It can be considered as an acute stroke of the eye, and is an ocular analogue of cerebral stroke. The incidence of CRAO is estimated to be 1 in 100 000 people. Risk factors include hypertension, carotid atherosclerosis, structural cardiac pathology, coronary heart disease, cerebral vascular accident, and diabetes mellitus. CRAO usually presents with a sudden, painless loss of vision. 52 - year old male was admitted to the Ophthalmology ER, reporting a painless monocular vision loss in a right eye for two days. After such a long time from the occurrence of symptoms, there weren’t any possible treatment methods for this patient, besides preventing future embolic events. Ophthalmological examination showed only a light perception in a right eye and vision in the left eye was 1.0. Patient was diagnosed to identify risk factors of CRAO: hypertension, hypercholesterolemia, atherosclerosis or thrombophilia. He was qualified for a careful observation for the atherosclerotic risk factors and educated, that in case of occurrence of the similar symptoms, he needs to report to a Ophthalmologist immediately. Currently, there are two main types of treating an acute non-arteritic CRAO: the first: ‘standard’, non-invasive method, and the second: using the thrombolytics deployed intravenously or intra-arterially. Unfortunately, they couldn’t be used to treat described patient, since he has already been in a late phase of CRAO. Key words: CRAO, occlusion, ophthalmology

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results