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11. Risk-Based Control Strategies of Recombinant Monoclonal Antibody Charge Variants

Author

Beck, Alain, primary, Nowak, Christine, additional, Meshulam, Deborah, additional, Reynolds, Kristina, additional, Chen, David, additional, Pacardo, Dennis B., additional, Nicholls, Samantha B., additional, Carven, Gregory J., additional, Gu, Zhenyu, additional, Fang, Jing, additional, Wang, Dongdong, additional, Katiyar, Amit, additional, Xiang, Tao, additional, and Liu, Hongcheng, additional

Published
2022
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13. Identification of Dihydroorotate Dehydrogenase Inhibitors Using the Cell Painting Assay

Author

Schölermann, Beate, primary, Bonowski, Jana, additional, Grigalunas, Michael, additional, Burhop, Annina, additional, Xie, Yusheng, additional, Hoock, Joseph G. F., additional, Liu, Jie, additional, Dow, Mark, additional, Nelson, Adam, additional, Nowak, Christine, additional, Pahl, Axel, additional, Sievers, Sonja, additional, and Ziegler, Slava, additional

Published
2022
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16. Data Supplement

Author

Liu, Jen-Kai, Schüller, Margot, Grabmeier, Markus, Kotzel, Uwe, Nowak, Christine, and Schucher, Günter

Abstract

China aktuell, China aktuell - Data Supplement - 1/2005

Published
2020
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17. China Monthly Data

Author

Liu, Jen-Kai, Schüller, Margot, Schucher, Günter, Kotzel, Uwe, and Nowak, Christine

Abstract

China aktuell, China aktuell - September 2002

Published
2020
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18. The lipidated membrane anchor of full length N-Ras protein shows an extensive dynamics as revealed by solid-state NMR spectroscopy

Author

Reuther, Guido, Kui-Thong Tan, Vogel, Alexander, Nowak, Christine, Arnold, Klaus, Kuhlmann, Jurgen, Waldmann, Herbert, and Huster, Daniel

Subjects
Nuclear magnetic resonance spectroscopy -- Usage, Cellular signal transduction -- Research, Hydrophobic effect -- Analysis, Lipid membranes -- Structure, Lipid membranes -- Chemical properties, Chemistry
Abstract

A study reports the first comprehensive investigation of the molecular dynamics of the C-terminus of membrane-associated full-length lapidated Ras protein determined by solid-state nuclear molecular resonance. The C-terminus of Ras shows a versatile dynamics with segmental fluctuations and axially symmetric overall motions on the membrane surface.

Published
2006

20. Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket

Author

Karatas, Hacer, primary, Akbarzadeh, Mohammad, additional, Adihou, Hélène, additional, Hahne, Gernot, additional, Pobbati, Ajaybabu V., additional, Yihui Ng, Elizabeth, additional, Guéret, Stéphanie M., additional, Sievers, Sonja, additional, Pahl, Axel, additional, Metz, Malte, additional, Zinken, Sarah, additional, Dötsch, Lara, additional, Nowak, Christine, additional, Thavam, Sasikala, additional, Friese, Alexandra, additional, Kang, CongBao, additional, Hong, Wanjin, additional, and Waldmann, Herbert, additional

Published
2020
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22. Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta

Author

Braslavsky, Carolina J. Villa, Nowak, Christine, Gorlich, Dirk, Wittinghofer, Alfred, and Kuhlmann, Jurgen

Subjects
Cytochemistry -- Research, Carrier proteins -- Physiological aspects, Nuclear membranes -- Physiological aspects, Cellular signal transduction -- Physiological aspects, Binding sites (Biochemistry) -- Research, Chemical reaction, Rate of -- Physiological aspects, Cytoplasm -- Physiological aspects, Biological sciences, Chemistry
Abstract

Structural and kinetic requirements for interaction of Ran with the Ran-binding domains from RanBP2 and importin-beta are discussed. It appears that the C-terminus of Ran acts like a loose tether in Ran.GTP complexes of importins or exportins leaving the nucleus. The flag is recognized by the multiple RanBDis at or near the nuclear pore complex. That makes efficient disassembly of the Ran.GTP complexes possible.

Published
2000

23. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

Author

Vetter, Ingrid R., Nowak, Christine, Nishimoto, Takeharu, Kuhlmann, Jurgen, and Wittinghofer, Alfred

Subjects
Carrier proteins -- Research, Cell cycle -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The crystal structure of the complex of the first Ran-binding domain of human Ran-binding protein 2 (RanBP2) with Ran bound to a non-hydrolysable GTP analogue indicates a molecular mechanism to explain the function of RanBPs in nuclear transport. It is likely that the main function of Ran-binding domains is to sequester the C-terminal extension of Ran. There is currently no structural model for Ran-transport-factor complexes, and this makes it hard to identify the function of RanBPs as a 'dissociator' of nuclear-export complexes.

Published
1999

24. Impact of Particle Size Distribution on Performance of Lithium‐Ion Batteries

Author

Bl��ubaum, Lars, R��der, Fridolin, Nowak, Christine, Chan, Seng Hoon, Kwade, Arno, and Krewer, Ulrike

Subjects
ddc:620, Engineering & allied operations
Abstract

This work reveals the impact of particle size distribution of spherical graphite active material on negative electrodes in lithium���ion batteries. Basically all important performance parameters, i. e. charge/discharge characteristics, capacity, coulombic and energy efficiencies, cycling stability and C���rate capability are shown to be affected by distribution shapes. A narrow distribution with smaller particles results in better cell performance than broader and coarser distributions. However, particle size reduction has a limitation as extremely small particles show negative effect in performance. More critically, independent of the particle size distribution, the existence of coarse particles are found to promote lithium plating, which lowers cell performance and threatens the safety of battery operation. Furthermore, impedance analysis and cycling stability show huge differences for different electrodes. Our study shows that a better understanding of the influence of particle size distribution is an important base to engineer electrodes with higher C���rate capability, higher performance, and lower safety risk due to lithium plating.

Published
2020

30. Die Skanska-Entscheidung des EuGH - Haftung des Rechtsnachfolgers bei Kartellschadensersatz, aber keine Haftung der „wirtschaftlichen Einheit”.

Author

Kremer, Michael J. R. and Nowak, Christine

Abstract

Copyright of Wirtschaft und Wettbewerb is the property of Fachmedien Otto Schmidt KG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

31. Enhanced Processing and Testing Concepts for New Active Materials for Lithium‐Ion Batteries.

Author

Bockwinkel, Kai, Nowak, Christine, Thiede, Bastian, Nöske, Markus, Dietrich, Franz, Thiede, Sebastian, Haselrieder, Wolfgang, Dröder, Klaus, Kwade, Arno, and Herrmann, Christoph

Subjects
LITHIUM-ion batteries, MANUFACTURING processes, INTERMEDIATE goods, MATERIALS, MANUAL labor, GRINDING machines
Abstract

Electrode manufacturing requires multiple process steps, e.g., dispersing and coating. In‐between these steps, intermediate products have to be transferred, stored, and handled. Especially for the development of new active materials or electrode formulations, the variety of parameters that need to be screened is enormous. In addition, these materials are initially tested in small batches, and it is not always possible to upscale the used processes. To evaluate the performance of different materials or differently processed materials, test cells are assembled. This usually requires manual work procedures, which are inherently sensitive to variations and untraceable errors. If the stochastic flaws are large enough, the effects of process variations are covered by these. It is therefore important to increase reproducibility in all process steps. Herein, new concepts for electrode production and automated sample preparation for highly reproducible production and more effective electrode development and screening of parameters are presented. A combined grinding and dispersion process for the production of silicon‐based anodes and an automated assembly system for efficient testing is presented. The processes are supported by methods of data mining to collect process data, ensure high reproducibility, and support research on new active materials. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Structure, heterogeneity and developability assessment of therapeutic antibodies

Author

Xu, Yingda, primary, Wang, Dongdong, additional, Mason, Bruce, additional, Rossomando, Tony, additional, Li, Ning, additional, Liu, Dingjiang, additional, Cheung, Jason K, additional, Xu, Wei, additional, Raghava, Smita, additional, Katiyar, Amit, additional, Nowak, Christine, additional, Xiang, Tao, additional, Dong, Diane D., additional, Sun, Joanne, additional, Beck, Alain, additional, and Liu, Hongcheng, additional

Published
2018
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34. Analytical comparability study of recombinant monoclonal antibody therapeutics

Author

Ambrogelly, Alexandre, primary, Gozo, Stephen, additional, Katiyar, Amit, additional, Dellatore, Shara, additional, Kune, Yune, additional, Bhat, Ram, additional, Sun, Joanne, additional, Li, Ning, additional, Wang, Dongdong, additional, Nowak, Christine, additional, Neill, Alyssa, additional, Ponniah, Gomathinayagam, additional, King, Cory, additional, Mason, Bruce, additional, Beck, Alain, additional, and Liu, Hongcheng, additional

Published
2018
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39. Cover Feature: Revealing the Impact of Particle Size Distribution on Ageing of Lithium‐Ion Batteries with Frequency Response Analysis (Batteries & Supercaps 10/2023).

Author

Seng Chan, Hoon, Bläubaum, Lars, Vijayshankar, Dandapani, Röder, Fridolin, Nowak, Christine, Weber, André, Kwade, Arno, and Krewer, Ulrike

Subjects
LITHIUM-ion batteries, PARTICLE size distribution, AGE distribution, ELECTRIC batteries, ELECTROCHEMICAL analysis, SODIUM ions
Abstract

Polydispersity, electrode-resolved analysis, electrochemical impedance spectroscopy, distribution of relaxation time, nonlinear frequency response analysis, electrochemistry, surface analysis Cover Feature: Revealing the Impact of Particle Size Distribution on Ageing of Lithium-Ion Batteries with Frequency Response Analysis (Batteries & Supercaps 10/2023) Keywords: polydispersity; electrode-resolved analysis; electrochemical impedance spectroscopy; distribution of relaxation time; nonlinear frequency response analysis; electrochemistry; surface analysis EN polydispersity electrode-resolved analysis electrochemical impedance spectroscopy distribution of relaxation time nonlinear frequency response analysis electrochemistry surface analysis 1 1 1 10/10/23 20231001 NES 231001 B The Cover Feature b shows the particle-size specific ageing in lithium-ion batteries and its detection with nonlinear and linear frequency response analysis methods. [Extracted from the article]

Published
2023
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