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1. Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone

Author

Stempel, Da, Raphiou, Ih, Kral, Km, Yeakey, Am, Emmett, Ah, Prazma, Cm, Buaron, Ks, Pascoe, Sj, Austri, Investigators, Altieri, Hh, Antuni, Jd, Bergna, Ma, Cuadrado, Ja, De Gennaro MS, Fazio Lizandrelo CL, Gattolin, G, Gosn, Am, Larrateguy, Ld, Marcipar, Am, Maspero, Jf, Medina, Iv, Perez Chada RD, Silva, D, Victorio, Cf, Bardin, Pg, Carroll, Pa, Clements, Bs, Dore, Nd, Robinson, Pd, Fitzgerald, Da, Robinson, Pj, Russo, Ma, Sajkov, D, Thomas, Ps, Upham, Jw, Forstner, B, Kaik, G, Koeberl, Gh, Studnicka, M, Wallner, G, Balthazar, Y, Bauler, A, Dupont, Lj, Martinot, Jb, Ninane, V, Peché, R, Pilette, C, Dimitrova, R, Dimova, D, Kissyova Ibrishimova, G, Loboshka Becheva, M, Machkovska, M, Madjarov, S, Mandazhieva Pepelanova, M, Naidenova, I, Noleva, K, Takovska, N, Terziev, C, Aggarwal, Nk, Chapman, Kr, Csanadi, Ma, Dhillon, R, Henein, S, Kelly, Aj, Lam, As, Liem, Jj, Lougheed, Md, Lowe, Dw, Rizvi, Q, van den Berg, L, Zidel, B, Barros Monge MJ, Calvo Gil MA, Castillo Hofer CR, Diaz Amor PV, Lezana Soya, V, Quilodran Silva CN, Bolivar Grimaldos, F, Solarte-Rodriguez, I, Butkovic-Tomljanovic, R, Hegedus-Jungvirth, M, Ivkovic-Jurekovic, I, Simunov-Karuza, G, Buresova, M, Bursova, J, Fratrik, J, Guttlerova, E, Hartman, P, Jirmanova, I, Kalina, P, Kolman, P, Kucera, M, Povysilova, L, Pravda, P, Svabkova, A, Zakova, L, Backer, V, Maltbaek, N, Johnsen, Cr, Aries, Sp, Babyesiza, A, Barth, D, Benedix, A, Berg, P, Bergtholdt, B, Bettig, U, Bindig, Hw, Botzen, U, Brehler, R, Breyer, Go, Bruckhaus-Walter, M, Dapper, T, Eckhard, Jg, Engelhard, R, Feldmeyer, F, Fissan, H, Franz, Kh, Frick, Bs, Funck, J, Gessner, Cm, Ginko, T, Grigat, Ce, Grimm-Sachs, V, Groth, G, Hampf, J, Hanf, G, Havasi-Jost, G, Heinz, Gu, Helm, K, Hoeltz, S, Hofmann, S, Jander, R, Jandl, M, Jasch-Hoppe, B, Jung, T, Junggeburth, Jj, Kardos, P, Knueppel, W, Koch, T, Kolorz, C, Korduan, M, Korth-Wiemann, B, Krezdorn, Hg, Kroker, A, Kruell, M, Kuehne, P, Lenk, U, Liefring, E, Merke, J, Micke, L, Mitlehner, W, Mueller, H, Naudts, If, Neumann, G, Oldenburg, W, Overlack, A, Panzer, F, Reinholz, N, Remppis, R, Riegel, P, Rueckert, P, Schaetzl, Rj, Schauer, U, Hamelmann, E, Schenkenberger, I, Schlegel, V, Scholz, G, Schroers, M, Schwittay, A, Sebert, M, Tyler, K, Soemantri, Pa, Stock, P, Stuchlik, G, Unland, M, von Mallinckrodt, C, Wachter, J, Weber, U, Weberling, F, Wehgartner-Winkler, S, Weimer, J, Wiemer, S, Winkelmann, Ej, Zeisler, Kh, Ziegner, A, Zimny, Hh, Andrasofszky, Z, Bartha, A, Farkas, M, Gömöri, K, Kis, S, Major, K, Mészáros, I, Mezei, M, Rakvacs, M, Szalai, Z, Szántó, J, Szentesi, M, Szolnoki, E, Valyon, E, Zibotics, H, Anwar, J, Arimah, C, Djajalaksana, S, Rai, Ib, Setijadi, Ar, Setyanto, Db, Susanti, F, Syafiuddin, T, Syamsi, Ln, Wijanarko, P, Yunus, F, Bonavia, M, Braga, M, Chetta, Aa, Cerveri, I, Luisetti, M, Crimi, N, Cutrera, R, De Rosa, M, Esposito, S, Foresi, A, Gammeri, E, Iemoli, E, Legnani, Dl, Michetti, G, Pastorello, Ea, Pesci, A, Pistolesi, M, Riva, E, Romano, A, Scichilone, N, Terracciano, L, Tripodi, S, Choi, I, Kim, C, Kim, Js, Kim, Wj, Koh, Yy, Kwon, Ss, Lee, Sh, Lee, S, Lee, Sk, Park, Cs, Cirule, I, Eglite, R, Petrova, I, Poga, M, Smiltena, I, Chomiciene, A, Davoliene, I, Griskeviciene, V, Naudziunas, A, Naudziunas, S, Rudzeviciene, O, Sitkauskiene, B, Urbonas, G, Vaicius, D, Valavicius, A, Valiulis, A, Vebriene, J, bin Abdul Aziz FA, Daud, M, Ismail, Ai, Tengku Saifudin TI, Md Kassim RM, Mohd Fadzli FB, Wan Mohamad WH, Aguilar Dominguez PE, Aguilar-Orozco, Ra, Garza-Salinas, S, Ramirez-Diaz, Sp, Sánchez Llamas, F, Soto-Ramos, M, Velarde-Mora, Hj, Aguirre Sosa, I, Cisneros, Am, Estrella Viladegut RA, Matsuno Fuchigami, A, Adiaz-Baui, Tt, Bernan, Ap, Onia, Af, Sandagon, Mj, S-Naval, S, Yu, Cy, Bartuzi, Z, Bielous-Wilk, A, Błażowski, Ł, Bożek, A, Brzostek, J, Chorostowska-Wynimko, J, Ciekalska, K, Ziora, D, Cieslicki, J, Emeryk, A, Folcik, K, Gałuszka-Bilińska, A, Gawlik, R, Giejlo, M, Harat, R, Hofman, T, Jahnz-Różyk, K, Jedrzejczak, M, Kachel, T, Kamiński, D, Kelm Warchol, A, Konieczny, Z, Kwasniewski, A, Leszczyński, W, Mincewicz, G, Niezgoda, K, Olszewska-Ziąber, A, Onasz-Manitius, M, Pawlukiewicz, M, Piotrowicz, P, Piotrowski, W, Pisarczyk-Bogacka, E, Piskorz, P, Prokop-Staszecka, A, Roslan, A, Słomka, A, Smalera, E, Stelmach, I, Swierczynska-Krepa, M, Szmidt, M, Tarnowska-Matusiak, M, Tłuczykont, B, Tyminska, K, Waszkuc-Golonko, J, Wojciechowska, I, Alexandrescu, Ds, Neamtu, Ml, Todea, D, Alekseeva, E, Aleksandrova, E, Asherova, I, Barbarash, Ol, Bugrova, O, Bukreeva, Eb, Chermenskiy, A, Chizhova, O, Demko, I, Evdokimova, A, Giorgadze, Ml, Grigoryev, S, Irkhina, I, Khurkhurova, Nv, Kondyurina, Eg, Kostin, Vi, Kudelya, L, Laleko, Sl, Lenskaya, L, Levashov, S, Logvinenko, N, Martynov, A, Mizernitski, Y, Nemtsov, B, Novozhenov, Vg, Pavlishchuk, S, Popova, Vv, Reshetko, Ov, Sherenkov, A, Shirinsky, Vs, Shpagina, L, Soloviev, Ki, Tkachev, A, Trofimov, Vi, Vertkin, Al, Vorobeva, E, Idrisova, E, Yakushin, S, Zadionchenko, V, Zhiglinskaya, O, Zykov, K, Dopudja Pantic, V, Nadaskic, R, Nestorovic, B, Skodric Trifunovic, V, Stojanovic, A, Vukcevic, M, Vujic, T, Mitic Milikic, M, Banovcin, P, Horvathova, H, Karako, P Sr, Plutinsky, J, Pribulova, E, Szarazova, M, Zlatos, A, Adams, L, Badat, A, Bassa, A, Breedt, J, Bruning, A, Ellis, Gc, Emanuel, S, Fouche, Lf, Fulat, Ma, Gani, M, Ismail, Ms, Jurgens, Jc, Nell, H, Nieuwoudt, G, Noor, F, Bolliger, Ct, Puterman, As, Siddique, N, Trokis, Js, Vahed, Ya, Van Der Berg BJ, Van der Linden, M, Van Zyl, L, Visser, Ss, Antépara Ercoreca, I, Arnedillo Muñoz, A, Barbe Illa, F, Barreiro López, B, Blanco Aparicio, M, Boada Valmaseda, A, Bosque García, M, Bustamante Ruiz, A, Carretero Anibarro, P, Del Campo Matias, F, Echave-Sustaet, Jm, Espinosa de los Monteros Garde MJ, Garcia Hernandez GM, López Viña, A, Lores Obradors, L, Luengo Planas MT, Monsó Molas, E, Navarro Dourdil, A, Nieto García AJ, Perpina Tordera, M, Picado Valles, C, Rodriguez Alvarez Mdel, M, Saura Vinuesa, A, Serra Batlles, J, Soler Sempere MJ, Toran Montserrat, P, Valdés Cuadrado LG, Villasante Fernandez-Montes, C, Cheng, Sl, Chern, Jh, Chiu, Mh, Chung, Cl, Lai, Rs, Lin, Ck, Liu, Yc, Wang, Cc, Wei, Yf, Amer, L, Berenfus, Vi, Besh, L, Duka, Kd, Fushtey, Im, Garmash, N, Dudnyk, O, Godlevska, O, Vlasenko, Ma, Hospodarskyy, I, Iashyna, L, Kaladze, M, Khvelos, Si, Kostromina, Vp, Krakhmalova, O, Kryuchko, T, Kulynych, Ov, Krasko, Mp, Levchenko, O, Litvinova, T, Panina, Ss, Pasiyeshvili, Lm, Prystupa, Ln, Romaniuk, Li, Sirenko, I, Synenko, Vi, Vynnychenko, Lb, Yatsyshyn, Ri, Zaitsev, I, Zhebel, V, Zubarenko, O, Arthur, Cp, Brown, V, Burhan, H, Chaudhuri, R, Collier, D, Barnes, Nc, Davies, Ej, Ellery, A, Kwok, S, Lenney, W, Nordstrom, M, Pandya, Hc, Parker, Iw, Rajakulasingam, K, Seddon, P, Sharma, R, Thomas, Ec, Wakeling, Ja, Abalos-Galito, M, Abboy, C, Abreu, E, Ackerman, If, Acosta, Ia, Adaoag, Aa, Ahmed, M, Ali, Mi, Allen, Dr, Allen GG Jr, Diogo, Jj, Allison, Dc, Alwine, Lk, Apaliski, Sj, Arastu, Rs, Arora, Cm, Auerbach, D, Azzam, Sj, Badar FL 3rd, Baker, Jw, Barasch, Jp, Barber, Ma, Bardinas-Rodriguez, R, Barreiro, Tj, Baumbach, Rr, Baur, Ce, Baxter, Bs, Beach, Jl, Beasley, Rl, Beavins, Je, Beliveau, Wj, Benbow, Mj, Bennett, Nl, Bennett, Rl, Bernal, H, Bernstein, Di, Blaiss, Ms, Blumenthal, Kw, Boas, Sr, Borders, Jl, Boscia, Ja, Boulware, Wn, Bowling, Bt, Brabec, Ba, Bramlet, Dg, Figueroa, Dp, Brautigam, Df, Brownell, Jm, Bruce, Tr, Call, Rs, Campbell, Ca, Canaan, Ya, Cannon, Df, Carpio, Jm, Cathcart, Ws, Cevallos, Jp, Chauhan, Av, Chuang, Rb, Chevalier, D, Christensen, J, Christensen, Ta, Christina, Mo, Chrzanowski, Rr, Civitarese, Fa, Clark, Jp, Clifford, Dp, Lapidus, Rj, Coggi, Ja, Lenz, Jj, Cohen, Kr, Collins, Bg, Collins, H, Comellas, A, Condit, J, Cordasco EM Jr, Corder, Cn, Covar, Ra, Coverston, Kd, Croce, Sa, Cruz, H, Curtis, Ct, Daftary, Pk, Dalan, D, Dalawari, Sp, Daly, Wc, Davis, Kc, Dawes, Kw, Decotiis, Ba, Deluca, Rf, Desantis, Dm, De Valle OL, Diaz, Jl, Diaz, Jd, Dice, Jp, Elizalde, A, Hosler, Mr, Dixon, C, Dobkin, La, Dobrusin, Rs, Dransfield, Mt, Ebbeling, Wl, Edwards, Jd, Elacion, Jm, Elkayam, D, Ellison, Wt, Elsen, Jr, Engel, Lr, Ensz, Dj, Ericksen, Cl, Ervin, Je, Fang, C, Abrahamian, F, Farrah, Vb, Field, Jd, Fishman, Hj, Florea, R, Nayyar, S, Focil, A, Focauld, F, Franco MA Jr, Frandsen, Br, Ganti, K, Garcia, Fl, Lee, Wm, Garscadden, Ag, Gatti, Ea, Gellady, Am, George, Ar, Gibbon, Gw, Gleason, Gp, Goldberg, P, Goldstein, Mf, Gonzalez, Ge, Gower, Rg, Grande, Ja, Gregory, D, Grubb, Sd, Guthrie, Rp, Haas, Ta, Haft, Ks, Hajal, R, Hammond, Gd, Hansel, Nn, Hansen, Vr, Harris, Af, Hartman, An, Harvey, Rr, Hazan-Steinberg, S, Headley, Dm, Heigerick, Gc, Heller, Bn, Hendrix, El, Herrod, Jn, Hewitt, Mj, Hines, Rl, Hirdt, Ap, Hirschfield, Ja, Hoffman, Ks, Hogan, Ad, Howland, Wc, Hsu, Cc, Hsu, Fj, Hubbard, Wm, Hudson, Jd, Huffman, C, Hussain, M, Ioachimescu, Oc, Ismail, Ym, Jaffrani, Na, Jiang, N, Jones, Sw, Jordan, Rs, Joshi, Ke, Kaashmiri, Mw, Kalafer, M, Kamdar, Ba, Kanuga, Jg, Kao, Nl, Karetzky, M, Katsetos, Jc, Kay, Js, Kimmel, Ma, Kimura, Sh, Kingsley, Jk, Mahmood, Sm, Subich, Dc, Kirstein, Jl, Kleerup, Ec, Klein, Rm, Koh, Dw, Kohli, N, Koura, Fa, Kovacs, Sp, Kratzer, J, Kreit, Ci, Kreutter, Fm, Kubicki, Tm, Labuda, Jm, Latorre, Aj, Lara, Mm, Lechin, Ae, Lee, Jj, Lee, Md, Lentnek, Al, Lesh, Kw, Levins, Pf, Anspach, Rb, Levinsky, Dm, Lillestol, Mj, Lim, H, Livezey, Md, Lloyd-Turney, Cw, Lockey, Rf, Long, Ra, Lynch, Mj, Macgillivray, Bk, Mahadevan, Kp, Makam, Sk, Maloney, Mj, Mapel, D, Margolis, Bd, Margulies, J, Martin, Ef, Martin, Ee, Mascolo, M, Mataria, H, Sunbuli, M, Mathur, Rn, Mattar, Pn, Maynard, Km, Maynard, N, Mccormick, B, Mcelya, M, Mcevoy, Ce, Mckenzie, Wc, Medwedeff, Le, Mehta, Kd, Melamed, Ir, Meli, Jv, Merrick, Bh, Meyers, Pj, Miller, Bt, Minton, Sm, Miranda, Fg, Mohar, De, Montenegro, Ch, Morris, Fa, Morrison, Bs, Moss, Mh, Munoz, F, Naini, Gr, Nakamura, Ct, Naseeruddin, S, Nassim, C, Navazo, Lj, Nissim, Je, Norman, D, Oberoi, Ms, O'Connor, Tm, Offenberger, J, Orr, Rr, Osea, Ea, Paine, Wj, Rasmussen, Nl, Palatnik, M, Pangtay, D, Panuto, Ja, Patel, M, Perera, Ms, Perez, A, Peters PH Jr, Pimentel SM Jr, Pluto, Tm, Pollock, Mt, Posner, Ls, Pritchard, Jc, Pudi, Kk, Puig, Cm, Qaqundah, Py, Radbill, Mk, Rahman, St, Raikhel, M, Raissy, Hh, Ramstad, Ds, Ranasinghe, Es, Rangel, Os, Rapo, Se, Raschal, Sp, Reddy, Dg, Rehman, Sm, Reyes, Sr, Rhodes, Rb, Riffer, E, Rihal, Ps, Riley ED 4th, Rodriguez, Dh, Rogers, Cm, Rohlf, Jl, Romeu, H, Roney, Cw, Ronsick, So, Rosen, Jb, Rowe, Ms, Ruoff, Ge, Ryan, Eh, Saff, Rh, Saini, N, Anand, S, Balakrishnan, K, Samuels, Bs, Samuelson, Rj, Saniuk, Rj, Sargeant, Wo, Saunders, Mk, Saway, W, Scarupa, Md, White, Mv, Schear, Mj, Schwarz, Cm, Scott, Rb, Segall, N, Seibert, Af, Seidmeyer, V, Seidner, Mr, Seifer, Fd, Serje, J, Shah, Ms, Shah, Sb, Shapero, Pa, Shearer, Sd, Sheikh, Sq, Shepherd, Ts, Sher, Er, Sher, Ld, Short, Bh, Silas, Pe, Alvey, Jc, Silverfield, Jc, Simon, Sj, Sitar, S, Skoner, Dp, Smallow, Sa, Smart, Ba, Smith, Ca, Smith, Ke, Smith, Sk, Snyders, Gc, Soong, W, Soufer, J, Spangenthal, S, Stahlman, Je, Steele, Lg, Stegemoller, Rk, Stocks, J, Storms, Ww, Suen, J, Surowitz, Rz, Swauger, Jr, Taber, La, Tan, Ae, Pratt, Se, Tanus, T, Tarpay, Mm, Tarshis, Ga, Tenney, Jw, Tilghman, Kg, Trevino, Me, Troyan, Be, Twiddy, Sk, Updegrove, Jd, Urval, Kr, Uusinarkaus, Kt, Vaela, R, Van Cleeff, M, Varano, S, Vo, Qd, Wainz, Rj, Wald, Ja, Wall, Sj, Wasserman, Rl, Weinstein, Dl, Welker, Ja, Wellmon, B 2nd, Wells, T, Wenocur, Hs, Williams, Dl, Williams, Sl, Win, Ph, Wingo, Td, Wisman PP Jr, Wyszomierski, Da, Yamada, Hm, Yarows, S, Yunger TM Jr, Ziering, Rw., the AUSTRI Investigators, Stempel, D., Raphiou, I., Kral, K., Yeakey, A., Emmett, A., Prazma, C., Buaron, K., and Pascoe, S. Scichilone N tra i collaboratori

Subjects
Male, asthma, serious events, fluticasone, salmeterol, AUSTRI, Exacerbation, Intention to Treat Analysi, INHALED CORTICOSTEROIDS, Severity of Illness Index, law.invention, 0302 clinical medicine, Randomized controlled trial, law, immune system diseases, Ús terapèutic, Broncodilatadors, 030212 general & internal medicine, Child, Fluticasone, RISK, ACTING BETA-AGONISTS, EXACERBATIONS, METAANALYSIS, MORTALITY, SAFETY, DEATH, FDA, Medicine (all), Hazard ratio, General Medicine, Bronchodilator agents, Middle Aged, Fluticasone-Salmeterol Drug Combination, Bronchodilator Agents, Intention to Treat Analysis, Anesthesia, Female, Salmeterol, medicine.drug, Human, Adult, medicine.medical_specialty, Adolescent, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Fluticasone propionate, 03 medical and health sciences, Double-Blind Method, Internal medicine, Administration, Inhalation, medicine, Humans, Asma, Bronchodilator Agent, Asthma, Aged, Proportional Hazards Models, business.industry, Therapeutic use, medicine.disease, respiratory tract diseases, 030228 respiratory system, Fluticasone Propionate, Salmeterol Xinafoate Drug Combination, Proportional Hazards Model, business
Abstract

BACKGROUND The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate. METHODS In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of lifethreatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone–salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation. RESULTS Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone–salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthmarelated event in the fluticasone–salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P = 0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthmarelated intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone–salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone–salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P

Published
2016

2. Predictors of low efficacy of hepatitis B vaccination in hemodialysis (HD) patients

Author

Zubkin Ml, V. Shilo, V. Taranov, Y. Kozhokar, Novozhenov Vg, E. Selkova, A. Starchenko, Baranova Fs, V. Chervinko, and I. Stenina

Subjects
Microbiology (medical), medicine.medical_specialty, business.industry, viruses, virus diseases, General Medicine, biochemical phenomena, metabolism, and nutrition, surgical procedures, operative, Infectious Diseases, stomatognathic system, Hepatitis b vaccination, Internal medicine, Medicine, business, Hemodialysis hd
Published
2002
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4. Treatment of chronic hepatitis B with lamivudine in renal transplant recipients

Author

Igor G. Bakulin, Baranova Fs, A. Kovalchuk, E. Balakirev, V. Stahanova, V. Zolotarevsky, A. Stanke, I. Stenina, V. Chervinko, Zubkin Ml, and Novozhenov Vg

Subjects
Adult, Liver Cirrhosis, Male, Drug, Hepatitis B virus, medicine.medical_specialty, Time Factors, Biopsy, media_common.quotation_subject, 030232 urology & nephrology, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 030204 cardiovascular system & hematology, Clinical nephrology, Antiviral Agents, Biomaterials, 03 medical and health sciences, Hepatitis B, Chronic, 0302 clinical medicine, Chronic hepatitis, Renal Dialysis, Internal medicine, medicine, Humans, Hepatitis B e Antigens, Viremia, media_common, Immunosuppression Therapy, business.industry, Remission Induction, Lamivudine, Alanine Transaminase, General Medicine, Middle Aged, Hepatitis B, medicine.disease, Hepatitis C, Kidney Transplantation, Renal transplant, DNA, Viral, Immunology, Reverse Transcriptase Inhibitors, Female, business, Follow-Up Studies, medicine.drug
Abstract

Treatment of chronic hepatitis B in renal transplant recipients remains one of the major problems in clinical nephrology. Lamivudine is considered to be a drug of choice for these patients, however, its efficacy in patients with hepatitis B after renal transplantation (RT) has not been completely proven. Twenty-two RT recipients treated with lamivudine were evaluated. The duration of treatment was 15.6±1.9 months. Fourteen patients (64%) had normalization of aminotransferase (ALT); in 9 of them (41% of the whole group), serum HBV DNA was eliminated. Serum HBeAg was undetectable in 4 out of 15 (27%) previously positive patients. It has been statistically proven that the efficacy of lamivudine therapy correlates with degree of fibrosis and higher histological activity index values. We could not establish any correlation between the outcome of antiviral therapy and patients' age, sex, conditions of contagion (while on dialysis or after RT), time lapsed after the infection had been detected, duration of post-transplant period, type of immunosuppression, HBeAg positivity or negativity, ALT levels, concomitant HCV infection. The efficacy of antiviral HBV therapy is limited by the duration of lamivudine treatment: in 4 out of 5 patients with virologic response, the viremia condition relapsed several weeks after the medication had been stopped. Two patients continued to sustain their biochemical response and 1 patient had ALT levels elevated to above normal, but the value was almost twice as low as initially reported. Liver biopsy was repeated in 4 RT recipients after the end of antiviral therapy; in 3 of them positive morphologic changes were observed.

5. 77 Late results of hepatitis B vaccination in hemodialysis patients

Author

Igor G. Bakulin, E. Balakirev, V. Taranov, Novozhenov Vg, V. Chervinko, Baranova Fs, Zubkin Ml, and A. Stanke

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, Infectious Diseases, Hepatitis b vaccination, business.industry, medicine.medical_treatment, medicine, General Medicine, Hemodialysis, business, Late results
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6. [RHEUTMATIC MYALGIA COMPLICATED BY AA-AMYLOIDOSIS].

Author

Zubkin ML, Ovchinnikov YV, Frolova NF, Chervinko VI, Zagrebneva AI, Volodina EV, Stolyarevich ES, Chumikov AA, Novozhenov VG, and Radenska-Lopovok SG

Subjects
Aged, Comorbidity, Female, Humans, Amyloidosis epidemiology, Amyloidosis metabolism, Polymyalgia Rheumatica epidemiology, Serum Amyloid A Protein metabolism
Abstract

Rheumatic myalgia is associated with intense inflammation and, unlike other diseases, is very rarely complicated by AA- amyloidosis. Only 12 such cases have been described worldwide, most of them in combination with giant cell arteritis. The present article reports the first case of rheumatic myalgia complicated by AA-amyloidosis encountered in Russia and the relevant literature review.

Published
2015

7. [Chronic hepatitis B, hemosiderosis, and hepatic fibrosis in a renal graft recipient].

Author

Zubkin ML, Pavlov ChS, Chervinko VI, Semenenko TA, Balakirev EM, Zolotarevskiĭ VB, Frolov AV, Baranova FS, Repetiĭ NG, Bakulin IG, Stanke AA, and Novozhenov VG

Subjects
Antiviral Agents therapeutic use, Biopsy, Diagnosis, Differential, Female, Follow-Up Studies, Hemosiderosis diagnosis, Hemosiderosis therapy, Hepatitis B, Chronic diagnosis, Hepatitis B, Chronic therapy, Humans, Liver Cirrhosis diagnosis, Liver Cirrhosis therapy, Middle Aged, Phlebotomy methods, Prognosis, Hemosiderosis etiology, Hepatitis B, Chronic etiology, Kidney Failure, Chronic surgery, Kidney Transplantation adverse effects, Liver Cirrhosis etiology
Abstract

Chronic hepatitis B is a frequent concomitant disease in recipients of a renal graft that worsens results of kidney transplantation due to renal and extrarenal complications. Much rarer hemochromatosis either has genetic roots (hereditary hemochromatosis) or results from multiple blood transfusions and hemolysis during treatment by hemodialysis (secondary hemochromatosis). Combination of chronic hepatitis B and hemochromatosis increases the risk of chronic liver disease leading to cirrhosis and hepatocellular carcinoma. Success of antiviral therapy combined with massive phlebotomy is illustrated by a case of kidney transplantation to a patient with chronic hepatitis B of large duration and iron overload syndrome.

Published
2009

8. [The possibilities of element status evaluation in determination of antiviral therapy resistance in patients with chronic hepatitis C].

Author

Bakulin IG, Novozhenov VG, and Ivanova MA

Subjects
Adult, Antiviral Agents therapeutic use, Case-Control Studies, Drug Therapy, Combination, Elements, Female, Hepacivirus isolation & purification, Humans, Interferon alpha-2, Interferon-alpha therapeutic use, Male, Middle Aged, Recombinant Proteins, Treatment Outcome, Arsenic blood, Drug Resistance, Viral, Hepatitis C, Chronic diagnosis, Hepatitis C, Chronic drug therapy, Metals blood, Phosphorus blood
Published
2006

9. [Chronic hepatitis B and C in renal graft recipients].

Author

Zubkin ML, Balakirev EM, Chervinko VI, Zolotarevskiĭ VB, Baranova FS, Taranov VA, Bakulin IG, Stanke AA, Evseev AA, and Novozhenov VG

Subjects
Adolescent, Adult, Aged, Biopsy, Female, Follow-Up Studies, Hepacivirus immunology, Hepatitis B Antibodies immunology, Hepatitis B virus immunology, Hepatitis B, Chronic pathology, Hepatitis B, Chronic virology, Hepatitis C Antibodies immunology, Hepatitis C, Chronic pathology, Hepatitis C, Chronic virology, Humans, Kidney Failure, Chronic surgery, Kidney Transplantation pathology, Male, Middle Aged, Postoperative Complications, Prognosis, Risk Factors, Hepatitis B, Chronic etiology, Hepatitis C, Chronic etiology, Kidney Transplantation adverse effects
Abstract

Clinical and morphological features of chronic hepatitis B (CHB), C (CHC), and B+C (CHB+C) were studied in 283 renal graft recipients. High total bilirubin serum levels were detected significantly more often in CHB and CHB+C patients vs. CHC patients. High ALT activity was noted in 65% of CHB patients and only in 45% of CHC patients (p = 0.003). Stable low activity of hepatitis prevailed in renal recipients; it was noted in 56.7% of CHB patients, 66.2% of CHC patients, and 62% of CHB+C patients. The character of pathomorphological liver changes in chronic viral hepatitis was studied in 53 renal graft recipients using puncture biopsy. Histopathological activity index (HAI, Knodell R.G. et al., 1981) witnessed a more severe liver lesion in CHB vs. CHC and CHB+C. Thus, inflammatory activity in CHB was found to be minimal or low in 13 patients, and moderate or high in 11 patients, whilst a minimal or low activity in CHC or CHB+C was found in 16 and 10 patients, respectively, and a moderate activity was detected only in two and one, respectively (p = 0.016 and 0.024 compared with CHB). Advanced hepatic fibrosis or cirrhosis was significantly more frequent (p = 0.006) in CHB patients (eight out of 24) than in CHC ones (none out of 18). The rate of advanced sclerotic changes in CHB+C was lower (one out of 10 patients) than that in CHB, and similar to CHC. Thus, clinico-morphological manifestations were more prominent in renal graft recipients with CHB vs. CHC.

Published
2006

10. [The trace element status in patients with chronic hepatic diseases].

Author

Bakulin IG, Novozhenov VG, and Degoeva BA

Subjects
Adult, Biomarkers blood, Fatty Liver diagnosis, Fatty Liver, Alcoholic diagnosis, Fatty Liver, Alcoholic metabolism, Female, Humans, Liver Cirrhosis diagnosis, Male, Mass Spectrometry, Middle Aged, Regression Analysis, Trace Elements blood, Fatty Liver metabolism, Liver Cirrhosis metabolism, Trace Elements metabolism
Abstract

Despite of the achievements of pharmacology it is very actually to improve the diagnosis and therapy of different chronic hepatic diseases. The purpose of the investigation is to study trace element (TE) status in patients with chronic hepatic diseases for estimating the possibility of therapy efficiency improvement. 102 patients with chronic hepatic diseases, aged from 19 to 60 were clinically and laboratory investigated. Group 1 (36 patients) suffered from alcoholic liver cirrhosis, group 2 (35 patients) had chronic alcoholic steatohepatitis and group 3 (31 patients) had non-alcoholic steatohepatitis (NASH). Multielement blood plasma analysis by ICP-MS and ICP-OES was perfomed in the Center of Biotic Medicine (Moscow). The results showed the significant changes in TE status in patients with chronic hepatic diseases that proves the expediency of studying both the essential and toxic element in such patients to improve the diagnosis and to optimize the treatment. Patients with chronic hepatic diseases are characterized by changing of such elements as Al, Ca, Cu, K, Se, Zn, that leads to necessity of using them for diagnosis.

Published
2004

11. [Malnutrition in patients with chronic liver diseases].

Author

Bakulin IG, Novozhenov VG, and Kolobanova EV

Subjects
Adult, Blood Proteins analysis, Body Mass Index, Female, Hepatitis, Alcoholic metabolism, Hepatitis, Alcoholic pathology, Hepatitis, Alcoholic therapy, Hepatitis, Chronic pathology, Hepatitis, Chronic therapy, Humans, Liver metabolism, Liver pathology, Liver Cirrhosis, Alcoholic metabolism, Liver Cirrhosis, Alcoholic pathology, Liver Cirrhosis, Alcoholic therapy, Male, Malnutrition pathology, Malnutrition therapy, Micronutrients blood, Middle Aged, Nutritional Support, Hepatitis, Chronic metabolism, Malnutrition metabolism
Published
2004

12. [Correction of selenium deficiency in patients with pneumonia].

Author

Bakulin IG, Novozhenov VG, Orlov AM, Gmoshinskiĭ IV, and Mazo VK

Subjects
Adult, Deficiency Diseases etiology, Dose-Response Relationship, Drug, Food Additives therapeutic use, Humans, Male, Pneumonia diet therapy, Pneumonia drug therapy, Selenium blood, Deficiency Diseases diet therapy, Pneumonia complications, Selenium therapeutic use
Abstract

The estimation of selenium (Se) safety in patients with pneumonia is important for evaluation of antioxidant defense system capacity and the immune status of the patients. The research has been carried out on the serum Se levels in patients with pneumonia at standard treatment and at treatment with the usage of selenium enriched food supplement (Se-spirulina). The results of research have shown that application of additional selenium in amount providing physiological requirement leads to full varnishing its deficiency cases and to restoration in the majority of patients the suboptimum Se level.

Published
2004

13. [Significance of antibacterial therapy of Chlamydophila pneumoniae infection in patients with bronchial asthma].

Author

Khamitov RF, Pal'mova LIu, and Novozhenov VG

Subjects
Chlamydophila Infections etiology, Female, Humans, Male, Middle Aged, Quality of Life, Anti-Bacterial Agents administration & dosage, Asthma complications, Azithromycin administration & dosage, Chlamydophila Infections drug therapy, Chlamydophila pneumoniae
Abstract

Aim: To study effects of eradication of Chlamydophila pneumoniae CP) infection in bronchial asthma (BA) on BA course and changes in quality of life (QOL) in BA patients., Material and Methods: 194 BA patients in clinical remission participated in the trial. Microbiological diagnosis of asymptomatic CP infection was made serologically (ELISA, indirect enzyme immunoassay) using polymerase chain reaction. Clinical and biochemical tests, assessment of pulmonary ventilation function, QOL by AQLQ during 6-week antimicrobial therapy were made in 56 patients., Results: Patients with stable BA had high frequency of serological signs of clinically asymptomatic CP infection (52%) deteriorating BA symptoms and QOL. Antibacterial therapy of latent CP infection with azitromycin significantly improved BA course and QOL of BA patients., Conclusion: When laboratory tests detect CP infection in patients with long-term course of BA, especially in smoking males with moderate and severe BA it is clinically valid to prescribe addition of azitromycin to basic antiinflammatory treatment of BA.

Published
2004

18. [Heart failure in casualties with explosive mine trauma].

Author

Gadzhieva LR and Novozhenov VG

Subjects
Blast Injuries pathology, Heart Diseases etiology, Humans, Military Medicine, Military Personnel, Russia, Blast Injuries complications, Heart Diseases complications, Warfare
Published
2003

19. [Change in activity of angiotensin-converting enzyme in pneumonia and chronic obstructive lung diseases].

Author

Al'tshuler BIu, Poĭtman AP, Fedorova TA, Novozhenov VG, Belkov SA, Gordeev MN, Iarovaia GA, Neshkova EA, and Ustinov AA

Subjects
Bronchoalveolar Lavage Fluid, Humans, Peptidyl-Dipeptidase A metabolism, Pulmonary Disease, Chronic Obstructive metabolism
Abstract

Aim: To study the activity of angiotensin-converting enzyme (ACE) in patients with pneumonia and chronic obstructive lung diseases (COLD)., Material and Methods: Sixty nine patients with pneumonia and 77 with COLD were examined. The activity of ACE in the serum and bronchoalveolar lavage (BAL) and the effects of leukocytic elastase and concentrations of zinc, endogenous inhibitors, and activators were studied., Results: The patients with pneumonia in the acute phase of the disease have been found to have low ACE activity in both blood and BAL. As the inflammatory process comes to an end, ACE activity normalizes. In the patients with COLD, the activity of ACE is primarily decreased at remission. When COLD aggravates, the activity of ACE in blood and BAL increases. In pneumonia and COLD, the changes in ACE activity are more profound in BAL than in blood., Conclusion: The only cause of the altered activity of ACE in patients with COLD and pneumonia is a change in the concentration of the enzyme.

Published
2003

21. [Changes in angiotensin-converting enzyme activity in pneumonia and chronic obstructive lung diseases].

Author

Al'tshuler BIu, Roĭtman AP, Fedorova TA, Iarovaia GA, Neshkova EA, Novozhenov VG, and Belkov SA

Subjects
Biomarkers blood, Humans, Pulmonary Disease, Chronic Obstructive blood, Pneumonia enzymology, Pulmonary Disease, Chronic Obstructive enzymology, Renin metabolism
Abstract

The activity of angiotensin converting enzyme (ACE) was analysed in blood serum and bronchial fluid of 69 patients with acute pneumonia and 77 patients with chronic obstructive pulmonary diseases (COPD). In patients with pneumonia in acute phase ACE activity was lower in both serum and bronchial fluid. During recovery of patients with acute pneumonia ACE activity was normalizated. In patients with COPD ACE activity was lower in remission stage and higher (both serum and bronchial fluid) during COPD exacerbation. The changes of ACE activity were more pronounced in bronchial fluid than serum in both COPD and pneumonia.

Published
2002

23. [Nutrition mixes in the complex rehabilitation of young men with constitutional deficit of body weight].

Author

Novozhenov VG, Luft VM, Ruseĭkin VM, and Bakulin IG

Subjects
Adolescent, Hospitalization, Humans, Length of Stay, Male, Nutrition Disorders rehabilitation, Body Weight, Nutrition Disorders diet therapy
Abstract

It was investigated peculiarities of the constitutional malnutrition in 94 young men. The influence of oral supplementation by enteral nutrition on recovering 54 young men with constitutional malnutrition was examined. The results of investigation indicated a high efficacy of using oral supplementation in the complex treatment of malnourished young men. It results in improvement of patient's rehabilitation and reduce the time of hospitalization.

Published
2002

24. [Experience of nutritional support in late period of traumatic disease of wounded patients].

Author

Novozhenov VG, Bakulin IG, Luft VM, Sandler IuG, and Al'tshuler BIu

Subjects
Adult, Atrophy, Dyspepsia pathology, Humans, Inflammation diet therapy, Male, Nutritional Support, Treatment Outcome, Wound Healing, Wounds and Injuries pathology, Dietary Supplements, Dyspepsia diet therapy, Dyspepsia etiology, Wounds and Injuries complications
Abstract

There are no standards of nutritional support of wounded patients in different periods of disease. Influence of supplementation with Nutrition on dynamic of anthropometric indexes, some biochemical and laboratory parameters in wounded malnourished patients in the last period of disease was examined. The results of investigation indicated that supplementation with Nutrizon increased all tianthropometric indexes, normalized albumin blood level, nitrogen balance, decreased nitrogen of urine.

Published
2002

26. [Changes in the respiratory tract organs in patients with opiate addiction].

Author

Novozhenov VG and Pevtsov GV

Subjects
Adult, Bronchial Diseases pathology, Bronchial Diseases physiopathology, Female, Fibrosis, Humans, Lung Diseases pathology, Lung Diseases physiopathology, Male, Respiratory Function Tests, Sclerosis, Bronchial Diseases etiology, Lung Diseases etiology, Opioid-Related Disorders complications
Published
2001

29. [Infections caused by Mycoplasma pneumoniae].

Author

Khamitov RF, Pal'mova LIu, and Novozhenov VG

Subjects
Humans, Mycoplasma pneumoniae genetics, Mycoplasma pneumoniae immunology, Mycoplasma pneumoniae pathogenicity, Pneumonia, Mycoplasma epidemiology, Pneumonia, Mycoplasma immunology, Pneumonia, Mycoplasma microbiology
Published
2001

30. [Assessing the surgical risk in patients with concomitant cardiovascular diseases].

Author

Chernov AP, Belkov SA, Novozhenov VG, Bronskaia LK, Samokhin AIa, and Chushkin MI

Subjects
Humans, Risk Assessment, Risk Factors, Cardiovascular Diseases complications, Gastrointestinal Diseases complications, Gastrointestinal Diseases surgery, Lung Diseases complications, Lung Diseases surgery, Surgical Procedures, Operative adverse effects
Published
2001

32. [The medical rehabilitation of servicemen following aortocoronary bypass].

Author

Kremnev IuA, Zamotaev IuN, Mandrykin IuV, Novozhenov VG, Podshibiakin SE, and Kosov VA

Subjects
Adaptation, Psychological, Coronary Angiography, Coronary Artery Bypass psychology, Coronary Artery Bypass statistics & numerical data, Exercise Tolerance, Humans, Male, Middle Aged, Postoperative Complications epidemiology, Risk Factors, Russia, Time Factors, Coronary Artery Bypass rehabilitation, Military Personnel psychology, Military Personnel statistics & numerical data
Abstract

The results of aortocoronary shunting (ACSh) were studied in 243 patients after myocardial infarction at different stages of rehabilitation--in rehabilitative hospital and military sanatorium. Result assessment at the final stage of therapy in sanatorium confirmed ACSh efficiency in overwhelming majority of patients. At the same time principal peculiarities were revealed showing the necessity of differential approach to determination of volume and place for conduction of restorative therapy. Process of successful adaptation in most patients is achieved during the periods up to 8 weeks that corresponds to two-staged rehabilitative system. More long periods of therapy are required for patients having complications not arrested at hospital stage, low exercise tolerance, poor psychological readaptation. Optimization of rehabilitative system in order to determine the volume and place of rehabilitation will contribute to further improvement of staged therapy in such patient group.

Published
2000

33. [Distribution and features of infection with hepatitis viruses B and C during hemodialysis treatment].

Author

Zubkin ML, Selivanov NA, Stakhanova VM, Novozhenov VG, Sel'kova EP, Kucherova TE, Baranova FS, Kozhokar' IuV, Kirkhman VV, Kasapova EN, Stenina II, and L'vov DK

Subjects
Alanine Transaminase blood, Aspartate Aminotransferases blood, Genotype, Hepacivirus genetics, Hepatitis B enzymology, Hepatitis B transmission, Hepatitis C enzymology, Hepatitis C transmission, Humans, Prevalence, Hepatitis B epidemiology, Hepatitis C epidemiology, Renal Dialysis adverse effects
Abstract

The prevalence of hepatitides B and C was evaluated in 140 patients treated by hemodialysis. Almost half of patients (48%) had acute hepatitis B which completely resolved. Acute hepatitis B was detected in 6% in the course of observation. In 6% chronic hepatitis B was diagnosed, and in 24% chronic hepatitis C. A combination of hepatitides B and C was diagnosed in 2% patients. Only 12% patients were not infected with hepatitis. Genotype 1b predominated in patients with HCV infection (73%); genotypes 1a, 21, and 3a were equally incident (9%). Replication of HBV and HCV in patients with uremia under conditions of hemodialysis was detected in 83 and 86% patients, respectively. Relationship between HBV and HCV infection and the duration of hemodialysis treatment was analyzed. The percentage of non-infected patients persistently decreased, and the time course of HBV and HCV infection was different. Infection with HBV after the beginning of hemodialysis occurred sooner (16.0 +/- 4.0 months) than with HCV (30.2 +/- 4.6 months, p < 0.04). The levels of SGPT and SGOT in patients with various manifestations of HBV and HCV infection treated by hemodialysis were followed up.

Published
2000

34. [The rehabilitation of servicemen after myocardial revascularization].

Author

Kremnev IuA, Novozhenov VG, Zamotaev IuN, Mandrykin IuV, and Kosov VA

Subjects
Health Resorts, Humans, Male, Middle Aged, Myocardial Infarction psychology, Myocardial Infarction rehabilitation, Myocardial Infarction surgery, Myocardial Revascularization psychology, Psychophysiology, Russia, Military Personnel psychology, Myocardial Revascularization rehabilitation
Published
1999

35. [Difficulties in diagnosis of extrapulmonary tuberculosis running with hyperthermia and cytopenia].

Author

Chernov AP, Novozhenov VG, Belkov SA, Popova NS, Tokareva IIa, and Nikolaeva VK

Subjects
Anemia, Aplastic diagnosis, Diagnosis, Differential, Fatal Outcome, Female, Fever diagnosis, Follow-Up Studies, Humans, Middle Aged, Pancytopenia diagnosis, Tuberculosis, Miliary complications, Anemia, Aplastic complications, Fever complications, Pancytopenia complications, Tuberculosis, Miliary diagnosis
Published
1998

36. [Pneumonia in young males in extreme conditions].

Author

Novozhenov VG and Gembitskiĭ EV

Subjects
Adolescent, Adult, Afghanistan epidemiology, Environmental Exposure, Follow-Up Studies, Hospitalization, Humans, Immunoglobulins immunology, Incidence, Lipid Peroxidation physiology, Male, Military Personnel, Russia epidemiology, Stress, Psychological, T-Lymphocytes immunology, Warfare, Pneumonia, Bacterial epidemiology, Pneumonia, Bacterial etiology, Pneumonia, Bacterial metabolism
Published
1998

38. [The effect of protein deficiency on the clinical course of pneumonia and the immunological indices of young people].

Author

Novozhenov VG, Kriukov EV, and Popov IV

Subjects
Acute Disease, Adolescent, Adult, Antibody Formation, Disease Progression, Humans, Immunity, Cellular, Male, Military Personnel, Pneumonia, Pneumococcal diagnosis, Pneumonia, Pneumococcal immunology, Protein Deficiency diagnosis, Protein Deficiency immunology, Russia, Time Factors, Pneumonia, Pneumococcal etiology, Protein Deficiency complications
Published
1996

39. [The use of protein preparations in the combined treatment of pneumonia patients].

Author

Novozhenov VG, Kriukov EV, and Popov IV

Subjects
Adolescent, Adult, Combined Modality Therapy, Humans, Infusions, Intravenous, Pneumonia immunology, Protein Deficiency immunology, Protein Deficiency therapy, Russia, Time Factors, Amino Acids administration & dosage, Military Personnel, Pneumonia therapy, Serum Albumin administration & dosage
Published
1996

40. [Chronic obstructive bronchitis: its pathogenetic aspects and the characteristics of its clinical course].

Author

Novozhenov VG, Belonogov MA, Teselkin IuO, Kolomoets NM, Prishchepov IA, Terent'ev VA, and Kuleshova LS

Subjects
Adolescent, Adult, Antioxidants, Bronchitis blood, Bronchitis physiopathology, Bronchitis therapy, Chronic Disease, Disease Progression, Hospitalization, Humans, Lipid Peroxidation, Middle Aged, Recurrence, Respiration, Time Factors, Bronchitis etiology
Abstract

Lipid peroxidation (LPO) and antioxidant system (AOS) were examined in 40 inpatients with chronic obstructive bronchitis (COB) on conventional treatment. The above parameters were considered in relation to clinical picture. It is shown that inflammation in the bronchial tree is associated with AOS functional deterioration and marked LPO intensification. A correlation was established between LPO activity, concentration of alpha-tocopherol in red cell membrane and degree of bronchial obstruction as well as remission quality. Persistent high intensity of LPO is suggested as an underlying cause of the disease transition to chronic form and progression of bronchial obstruction. Basing on the above observations, the authors insist on antioxidants introduction in COB treatment.

Published
1996

41. [Pulmonary complications in severe combined craniocerebral trauma (their pathogenesis, clinical picture, diagnosis and treatment)].

Author

Gembitskiĭ EV, Kolomoets NM, and Novozhenov VG

Subjects
Acute Disease, Adult, Afghanistan, Combined Modality Therapy, Critical Care methods, Humans, Lung Diseases diagnosis, Lung Diseases therapy, Male, Military Personnel, USSR, Warfare, Blast Injuries complications, Brain Injuries complications, Lung Diseases etiology, Multiple Trauma complications, Skull injuries, Wounds, Penetrating complications
Abstract

Within 1979-1989 the authors treated 26 wounded soldiers and officers with brain injury inflicted by mine explosion. 5 patients were in severe condition, 18 in extremely grave and 3 in critical condition. The patients had concomitant blast injuries and contusions. Pulmonary complications observed in such patients compused to DIC and respiratory distress syndromes running in the presence of marked metabolic disorders, hypoxia and intoxication. It is thought important that conservative therapy of respiratory disorders in patients with brain traumas were not constricted with correction of bronchial obstruction. The additional intensive treatment of the above syndromes is needed including extracorporeal detoxication (plasmapheresis) and hyperbaric oxygenation.

Published
1996

42. [The pathogenesis of a broncho-obstructive syndrome in patients with chronic bronchitis].

Author

Novozhenov VG, Belonogov MA, Man'kov IuU, Kolomoets NM, Teselkin IuO, and Popova NS

Subjects
Adolescent, Adult, Antioxidants, Bronchitis blood, Bronchitis physiopathology, Chronic Disease, Humans, Lipid Peroxidation, Lung Diseases, Obstructive blood, Lung Diseases, Obstructive physiopathology, Middle Aged, Respiration, Syndrome, Bronchitis complications, Lung Diseases, Obstructive etiology
Abstract

Lipid peroxidation (LPO) and antioxidant system (AOS) were investigated in 40 patients with chronic obstructive bronchitis (COB) in relation to clinical features of the disease. Bronchial tree inflammation was associated with reduced AOS function and intensification of LPO which reached a new high level. LPO activity, tocopherol concentration in red cell membranes and the severity of respiratory obstructive syndrome were correlated. It is suggested that high LPO activity may underlie the disease chronicity and development of progressive irreversible bronchial obstruction. Antioxidant drugs are believed necessary for COB patients not only in acute, but also in regression and remission phases of the disease.

Published
1995

43. [Current problems in organizing therapeutic care].

Author

Ivashkin VT and Novozhenov VG

Subjects
Delivery of Health Care organization & administration, Disasters, Emergency Medical Services organization & administration, Russia, Warfare, Military Medicine organization & administration, Therapeutics
Abstract

The article studies the problems in organization of therapeutical care in Mobile Forces on the basis of the analysis of medical support of troops in local wars. The authors emphasize the high dynamics of changes in the structure of military disease hazards depending on different combat theaters. This fact proves the necessity to make a transition to a module principle of formation of medical units and establishments which provide medical care to the wounded and sick.

Published
1995

44. [Principles and methods of current pathogenetic therapy of acute pneumonia].

Author

Gembitskiĭ EV and Novozhenov VG

Subjects
Acute Disease, Adjuvants, Immunologic therapeutic use, Anti-Bacterial Agents therapeutic use, Antioxidants metabolism, Blood Transfusion, Hemoperfusion, Humans, Lipid Peroxidation, Plasmapheresis, Pneumonia etiology, Pneumonia metabolism, Time Factors, Pneumonia therapy
Published
1994

45. [The clinical course of acute pneumonia in servicemen in Afghanistan].

Author

Novozhenov VG, Kolomoets NM, Volchek IA, and Belonogov MA

Subjects
Acute Disease, Afghanistan epidemiology, Antibody Formation, Humans, Immunity, Cellular, Lipid Peroxidation, Pneumonia epidemiology, Pneumonia immunology, Pneumonia metabolism, Retrospective Studies, USSR epidemiology, Warfare, Military Personnel statistics & numerical data, Pneumonia diagnosis
Abstract

The study of 820 histories was carried out in order to ascertain characteristic features of clinical course of acute pneumonia in the conditions of Afghanistan. All these patients underwent treatment in the Central Military Hospital of the 40th Army in Kabul in 1980-1989. The immunity status, the the level of peroxide oxidation of lipids (POL), and the state of antioxidant system (AOS) were also studied in 132 patients. The clinical course of pneumonia in comparison with its manifestation on the territory of Russia was characterized by pronounced intoxication of an organism, broncho-obstruction, vast inflammatory infiltration, hyperactivization of the immune system, POL, and AOS exhaustion. All these factors correspond to the syndrome of disadoptative disorders. Medications recommended for complex treatment: antioxidants, immunoglobulins, albumin, low-molecular dextrans.

Published
1994

46. [The clinico-functional status of the organs and systems in pilots who participated in the cleanup of the aftereffects of the accident at the Chernobyl Atomic Electric Power Station].

Author

Nikolaevskiĭ EE and Novozhenov VG

Subjects
Adult, Aerospace Medicine, Dose-Response Relationship, Radiation, Follow-Up Studies, Humans, Middle Aged, Psychophysiology, Radiation Injuries epidemiology, Radiation Injuries physiopathology, Radiation Injuries psychology, Time Factors, Ukraine epidemiology, Accidents, Military Personnel statistics & numerical data, Nuclear Reactors, Power Plants, Radiation Injuries diagnosis
Published
1993

47. [Early detoxification therapy in radiation exposures].

Author

Belkov SA, Novozhenov VG, Klimov IA, Legeza VI, and Andriukhin VI

Subjects
Adult, Hodgkin Disease blood, Hodgkin Disease complications, Hodgkin Disease radiotherapy, Humans, Male, Radiation Injuries blood, Radiation Injuries etiology, Radiotherapy adverse effects, Time Factors, Toxemia blood, Toxemia etiology, Toxemia therapy, Radiation Injuries therapy, Sorption Detoxification
Abstract

According to the structural metabolic theory of radiation injuries radiotoxins perform a leading role in the development of disorders. The experiments have disclosed the characteristic features of the development of toxemia in irradiated organism. These data have served as a ground for studying the efficiency of various methods of detoxication. Metabolic plasmapheresis is seemed to be of most pronounced effect in comparison with other methods of detoxication. On the basis of the results of these studies several practical recommendations were provided for performing an early disintoxicative therapy in patients with radiation injuries.

Published
1993

48. [Changes in lipid peroxidation and the antioxidant system in patients with acute radiation sickness].

Author

Novozhenov VG, Lysenko AE, Podvigin AV, and Petunin VV

Subjects
Accidents, Acute Disease, Adult, Humans, Middle Aged, Nuclear Reactors, Power Plants, Ukraine, Antioxidants radiation effects, Lipid Peroxidation radiation effects, Radiation Injuries metabolism
Abstract

Peroxide oxidation of lipids and antioxidant system perform an important role for making an adequate response of cells, organs and systems to radiation influence. The results which were obtained made it possible to forward a supposition concerning the efficiency of antioxidant drugs for prophylaxis and treatment of radiation injuries. It seems to be perspective for military medicine to study the efficiency of antioxidants for prophylaxis of injuries among personnel in radioactive contamination zones.

Published
1993

49. [The characteristics of the course of reactive arthritis in Afghanistan].

Author

Kolomoets NM, Novozhenov VG, Volchek IA, Gorelov AI, and Antonov IuS

Subjects
Adolescent, Adult, Afghanistan, Antibody Formation, Arthritis, Reactive immunology, Arthritis, Reactive microbiology, Autoimmune Diseases etiology, Autoimmune Diseases immunology, Autoimmune Diseases microbiology, Bacteria isolation & purification, Humans, Immunity, Cellular, USSR, Arthritis, Reactive etiology, Military Personnel
Published
1992

50. [The therapeutic problems of medicine in catastrophes].

Author

Ivashkin VT, Kirillov MM, Novozhenov VG, Grigor'ev IuK, and Lysenko AE

Subjects
Accidents, Accidents, Occupational, Armenia, Chemical Industry, First Aid, Humans, Lithuania, Nuclear Reactors, Power Plants, Ukraine, Workforce, Disasters, Emergency Medical Services organization & administration
Abstract

There are lack of principle differences between the problems of medical aid during the military and civil disasters, and therefore one can draw a conclusion concerning the validity and necessity of using the experience of military medics in disaster medicine during peace-time. The following aspects are discussed: organization of therapeutic caring of the victims during Chernobyl's AES disaster, earthquake in Armenia and accident in chemical enterprise "Nitrogen" in Jonava. Requirements to the teams for emergency medical service have been formulated with determination of Principles of putting them into practice; the further directions of therapeutic aid improvement are outlined.

Published
1990

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