Search

Your search keyword '"Novotny, Paul"' showing total 1,022 results
Start Over Author "Novotny, Paul"
1,022 results on '"Novotny, Paul"'

8. Expanding Beyond Maximum Grade: Chemotherapy Toxicity over Time by Age and Performance Status in Advanced Non‐Small Cell Lung Cancer in CALGB 9730 (Alliance A151729)

Author

Wong, Melisa L, Gao, Junheng, Thanarajasingam, Gita, Sloan, Jeff A, Dueck, Amylou C, Novotny, Paul J, Jatoi, Aminah, Hurria, Arti, Walter, Louise C, Miaskowski, Christine, Cohen, Harvey J, Wood, William A, Feliciano, Josephine L, Stinchcombe, Thomas E, and Wang, Xiaofei

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Cancer, Lung Cancer, Clinical Research, Aging, Neurodegenerative, Neurosciences, Lung, Peripheral Neuropathy, Breast Cancer, Aged, Antineoplastic Combined Chemotherapy Protocols, Carboplatin, Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, Paclitaxel, Geriatric oncology, Chemotherapy, Lung cancer, Fatigue, Neuropathy, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundPrior comparisons of chemotherapy adverse events (AEs) by age and performance status (PS) are limited by the traditional maximum grade approach, which ignores low-grade AEs and longitudinal changes.Materials and methodsTo compare fatigue and neuropathy longitudinally by age (

Published
2021

12. Alliance A222001: A randomized, double-blind, placebo controlled phase II study of oxybutynin versus placebo for the treatment of hot flashes in men receiving androgen deprivation therapy.

Author

Stish, Brad J., primary, Mazza, Gina L., additional, Nauseef, Jones T., additional, Humeniuk, Michael Sandon, additional, Smith, Thomas J., additional, Tofthagen, Cindy, additional, Diaz Pardo, Dayssy Alexandra, additional, Chay, Christopher H., additional, Huang, Andrew Jonathan, additional, Naha, Kushal, additional, Tagawa, Scott T., additional, Chow, Selina Lai-ming, additional, Adams-Campbell, Lucile L., additional, Novotny, Paul J., additional, and Loprinzi, Charles L., additional

Published
2024
Full Text
View/download PDF

13. Frailty and Clinical Outcomes in Chronic Obstructive Pulmonary Disease

Author

Kennedy, Cassie C, Novotny, Paul J, LeBrasseur, Nathan K, Wise, Robert A, Sciurba, Frank C, and Benzo, Roberto P

Subjects
Lung, Clinical Research, Aging, Respiratory, Good Health and Well Being, Aged, Female, Forced Expiratory Volume, Frail Elderly, Hospitalization, Humans, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Quality of Life, Retrospective Studies, Surveys and Questionnaires, Survival Analysis, United States, Walk Test, frailty, COPD, survival, hospitalizations, quality of life
Abstract

RationaleFrailty represents an increased vulnerability to adverse health outcomes. The frailty phenotype conceptual model (three or more patient attributes of wasting, exhaustion, low activity, slowness, and weakness) is associated with increased morbidity and mortality in geriatric populations.ObjectivesOur objective was to describe the risks associated with frailty in patients with chronic obstructive pulmonary disease.MethodsData from the National Emphysema Treatment Trial (NETT) were retrospectively analyzed. The frailty phenotype conceptual model was operationalized as three or more frailty parameters (a body mass index decrease of ≥5% over 12 months, self-reported exhaustion, low 6-minute walk distance, or physical activity or respiratory muscle strength in the lowest quartile). Frail participants were compared with participants with two or fewer frailty parameters. Participants were followed starting 12 months after NETT randomization (to minimize surgical effect) for 24 months. Univariate, multivariate, Kaplan-Meier, and Cox proportional hazard analyses were performed, adjusting for treatment arm, age, modified Medical Research Council dyspnea scale, sex, and baseline forced expiratory volume in 1 second (FEV1). Multiple imputation was used for missing values.ResultsThe participants (N = 902) were predominantly white (94.5%) males (59.5%), with a median age of 67 years (interquartile range, 63-70 yr) and a median FEV1% predicted of 26 (interquartile range, 20-33). Six percent of the participants (95% confidence interval [CI], 4.5 to 7.6) were frail. The incidence rate of frailty was 6.4 per 100 person-years. Frail participants reported significantly worse disease-specific and overall quality of life by St. George's Respiratory Questionnaire total score (mean difference of 11.6; 95% CI, 7.6 to 15.6; P < 0.001), mental composite on Medical Outcomes Survey Short Form-36 (mean difference -6.8; 95% CI, -10.0 to -3.6; P < 0.001), and physical composite scores on Medical Outcomes Survey Short Form-36 (mean difference -16.7; 95% CI, -21.3 to -12.1; P = 0.001). Frail participants had an increased rate of hospitalization (adjusted hazard ratio, 1.6; 95% CI, 1.1 to 2.5; P = 0.02) and an adjusted increase in hospital use of 8.0 days (95% CI, 4.4 to 11.6; P < 0.001) compared with nonfrail participants. Frail participants had a higher mortality rate (adjusted hazard ratio, 1.4; 95% CI, 0.97 to 2.0; P = 0.07).ConclusionsAmong adults with chronic obstructive pulmonary disease, our measure of frailty (modified from the Fried frailty phenotype) was associated with incident and longer-duration hospitalization, and with poor quality of life.

Published
2019

14. Low income as a determinant of exercise capacity in COPD

Author

Porta, Ana Sofia, Lam, Nyanjok, Novotny, Paul, and Benzo, Roberto

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Lung, Behavioral and Social Science, Chronic Obstructive Pulmonary Disease, Clinical Research, Clinical Trials and Supportive Activities, Rehabilitation, Respiratory, Good Health and Well Being, Aged, Exercise Test, Exercise Therapy, Exercise Tolerance, Female, Forced Expiratory Volume, Humans, Income, Male, Pulmonary Disease, Chronic Obstructive, Quality of Life, Socioeconomic Factors, COPD, social determinants of health, exercise capacity, quality of life, pulmonary rehabilitation, CPET, 6-minute walking test, NETT Research Group, Cardiorespiratory Medicine and Haematology, Respiratory System, Cardiovascular medicine and haematology
Abstract

Exercise capacity (EC) is a critical outcome in chronic obstructive lung disease (chronic obstructive pulmonary disease (COPD)). It measures the impact of the disease and the effect of specific interventions like pulmonary rehabilitation (PR). EC determines COPD prognosis and is associated with health-care utilization and quality of life. Field walking tests and cardiopulmonary exercise test (CPET) are two ways to measure EC. The 6-minute walking test (6MWT) is the commonest and easiest field test. CPET has the advantage of assessing maximal aerobic capacity. Determinants of EC include age, gender, breathlessness, and lung function. Previous research suggests that socioeconomic status (SES), a meaningful factor in COPD, may also be associated with EC. However, those findings have not been replicated. We aimed to determine whether SES is an independent factor associated with EC in COPD. For this analysis, we used the National Emphysema Treatment Trial (NETT) database. NETT was a multicenter clinical trial where severe COPD patients were randomized to lung volume reduction surgery or medical therapy. Measures used were taken at baseline, postrehabilitation. Patients self-reported their income and were divided in two groups whether it was less or above US$30,000. Patients with a lower income had worse results in 6MWT ( p < 0.0001). We found an independent association between income and the 6MWT in patients with severe COPD after adjusting for age, gender, lung function, dyspnea, and living conditions ( p < 0.0007). One previous publication stated the relationship between income and EC. Our research confirms and extends previous publications associating EC with income by studying a large and well characterized cohort of severe COPD patients, also addressing EC by two different methods (maximal watts and 6MWT). Our results highlight the importance of addressing social determinants of health such as income when assessing COPD patients.

Published
2019

15. Negative Mood is Associated with Sociobehavioral Factors Contributing to Cardiovascular Risk in an Immigrant Population

Author

Tranby, Brianna N., primary, Sia, Irene G., additional, Clark, Matthew M., additional, Novotny, Paul J., additional, Lohr, Abby M., additional, Pardo, Laura Suarez, additional, Patten, Christi A., additional, Iteghete, Sheila O., additional, Zeratsky, Katherine A., additional, Rieck, Thomas M., additional, Molina, Luz, additional, Capetillo, Graciela Porraz, additional, Ahmed, Yahye, additional, Dirie, Hana, additional, and Wieland, Mark L., additional

Published
2024
Full Text
View/download PDF

18. A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102

Author

Cathcart-Rake, Elizabeth, Novotny, Paul, Leon-Ferre, Roberto, Le-Rademacher, Jennifer, Storrick, Elizabeth M., Adjei, Araba A., Terstriep, Shelby, Glaser, Rebecca, Giuliano, Armando, Mitchell, William R., Page, Seth, Austin, Colleen, Deming, Richard L., Ferreira, Margaret A., Lafky, Jacqueline M., Birrell, Stephen N., and Loprinzi, Charles L.

Published
2021
Full Text
View/download PDF

21. Association of social network factors with weight status and weight loss intentions among hispanic adults

Author

Wieland, Mark L., Njeru, Jane W., Okamoto, Janet M., Novotny, Paul J., Breen-Lyles, Margaret K., Goodson, Miriam, and Porraz Capetillo, Graciela D.

Subjects
Social networks -- Health aspects, Hispanic Americans -- Social aspects -- Health aspects, Weight loss -- Social aspects -- Methods, Psychology and mental health
Abstract

Hispanic adults have the highest obesity prevalence in the United States, but little is known about weight-related social network influences. A community-based sample of 610 Hispanic participants completed height/weight and a survey. The proportion of overweight or obese (OW/OB) network members was higher for OW/OB respondents compared to normal weight respondents. Participants with high weight loss intentions reported more positive social norms for weight control, social support, and social cohesion. If most or all of OW/OB participant's social contacts were trying to lose weight, the odds that they were likely to try to lose weight was four times higher than other participants. The relationship between weight loss intentions and number of social contacts trying to lose weight was strongly mediated by social norms for weight control and social support. These results suggest that social contacts and functional network characteristics may impact weight status and weight control intentions among Hispanic adults., Author(s): Mark L. Wieland [sup.1] [sup.6] , Jane W. Njeru [sup.1] [sup.6] , Janet M. Okamoto [sup.2] , Paul J. Novotny [sup.3] , Margaret K. Breen-Lyles [sup.2] , Miriam Goodson [...]

Published
2020
Full Text
View/download PDF

25. Clinicopathologic characteristics, prognostication and treatment outcomes for myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U): Mayo Clinic-Moffitt Cancer Center study of 135 consecutive patients

Author

Mangaonkar, Abhishek A., Swoboda, David M., Coltro, Giacomo, Lasho, Terra L., Novotny, Paul J., Pophali, Prateek, Carr, Ryan M., Binder, Moritz, Finke, Christy M., Gangat, Naseema, Al-Kali, Aref, Begna, Kebede H., Reichard, Kaaren K., Ketterling, Rhett P., Al Ali, Najla H., Vafaii, Pardis, Zhang, Ling, Padron, Eric, Talati, Chetasi, and Patnaik, Mrinal M.

Published
2020
Full Text
View/download PDF

29. Patient Engagement in Health Coaching and Self-Management Abilities in Chronic Obstructive Pulmonary Disease.

Author

Benzo, Maria V., Kelpin, Sydney S., Werneburg, Brooke, Hoult, Johanna, Clark, Matthew M., Novotny, Paul, and Benzo, Roberto

Subjects
HEALTH education, HOME environment, MINDFULNESS, PATIENT participation, SELF-management (Psychology), COMMUNICATIVE competence, MOTIVATIONAL interviewing, BREATHING exercises, MEDICAL care, REGRESSION analysis, HELPLINES, RESPONSIBILITY, MEDICAL care use, SELF-efficacy, PRE-tests & post-tests, OBSTRUCTIVE lung diseases, QUESTIONNAIRES, QUALITY of life, HEALTH behavior, DESCRIPTIVE statistics, RESEARCH funding, PATIENT-professional relations, TELEMEDICINE, GOAL (Psychology)
Abstract

Objective : Health coaching has the potential to improve self-management abilities (SM) in patients with Chronic Obstructive Pulmonary Disease (COPD). Patient engagement with health care providers has a beneficial effect on patient outcomes. We examined the association of patient engagement with the health coach on SM abilities in patients with COPD. Methods : We analyzed the association between the degree of engagement measured by the Working Alliance Inventory (WAI-SR) and the SM measured by the Self-Management-Ability-Scale-30 (SMAS-30) at the end of a COPD health coaching intervention. Results : The cohort included 146 moderate to severe COPD patients. The WAI-SR total score was 85% of the maximum possible scores indicating a high degree of engagement between the health coach and the patients. The WAI-SR Task and Bond domains were positively associated with SM abilities after adjusting for lung function (FEV1 %) and depression symptoms (PHQ-2). Conclusion : The degree of engagement between a health coach and patients is associated with the perception of SM abilities in patients with COPD. Our results may inform self-management intervention and clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

31. Longitudinal cognitive function and brain metabolites in women receiving chemotherapy for stage 1 to 3 breast cancer: Observational study

Author

Beyer, Joana, primary, Couch, Ronan, additional, Ruddy, Kathryn J., additional, Zeydan, Burcu, additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Novotny, Paul J., additional, Kohli, Sadhna, additional, Cerhan, Jane H., additional, Pruthi, Sandhya, additional, Kantarci, Kejal, additional, and Kara, Firat, additional

Published
2023
Full Text
View/download PDF

35. Maintenance Sunitinib following Initial Platinum-Based Combination Chemotherapy in Advanced-Stage IIIB/IV Non–Small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study—CALGB 30607 (Alliance)

Author

Baggstrom, Maria Q., Socinski, Mark A., Wang, Xiaofei F., Gu, Lin, Stinchcombe, Thomas E., Edelman, Martin J., Baker, Sherman, Jr., Feliciano, Josephine, Novotny, Paul, Hahn, Olwen, Crawford, Jeffrey A., and Vokes, Everett E.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results