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Background: Left ventricular assist device (LVAD) candidates are at increased risk of immune dysregulation and infectious complications. To attenuate the elevated proinflammatory cytokine levels and associated adverse clinical outcomes, it has been postulated that extracorporeal blood purification could improve the overall survival rate and morbidity of patients undergoing LVAD implantation. Methods: We retrospectively reviewed prospectively collected data of 15 patients who underwent LVAD implantation at our center between January 2021 and March 2022. Of these, 15 (100%) who received HeartMate 3™ (St. Jude Medical, Abbott, MN, USA) device were eligible. Intraoperatively, patients were single randomized 1:1:1 to three groups: group 1, patients who received Cytosorb therapy (n = 5; installed in the CPB circuit); group 2, patients who received Jafron HA330 (n = 5; installed in the CPB circuit); and control group 3, patients who did not receive filter (n = 5; usual care, neither Cytosorb nor Jafron during CPB). Baseline patient characteristics and intraoperative data were compared between the groups. Blood sample analyses were performed to assess the levels of inflammatory markers (IL-1, 6, 8; CRP, Leukocyte, Lactate, PCT, NT-proBNP, TNF-α) in both preoperative and postoperative data. Results: Baseline patient characteristics were similar in all three groups. We found that IL1α; IL 6; IL8; Lactatedehydrogenase, PCT, pro-BNP, CRP; Leukocyte, and TNFα levels significantly increased with LVAD implantation and that neither Cytosorb nor Jafron influenced this response. In-hospital mortality and overall survival during follow-up were similar among the groups. Conclusion: Our preliminary results showed that hemoadsorption therapy using Cytosorb or Jafron hemoadsorption (HA) 330 may not be clinically beneficial for patients with advanced heart failure undergoing LVAD implantation. Large prospective studies are needed to evaluate the potential role of HA therapy in improving outcomes in patients undergoing LVAD implantation.

The relevance of the study is caused by the necessity to form a plan for the development of secondary vocational education that provides training of the most popular and promising specialties and working professions in accordance with international standards and advanced technologies on the basis of the leading professional educational organizations. The goal of this article is to identify the main motives and meanings of applicants' choices of popular and prospective specialties of secondary vocational education and working professions during the psychological, pedagogical and sociological research to paint a sociological portrait of students of vocational education and specialties from the TOP-50 list. The goals of the research are to carry out a comparative analysis of: 1) professional self-determination, 2) value orientations, 3) attitudes toward the teaching and upbringing, 4) life plans of applicants and students. The leading method in investigating this problem is the method of questioning. In our study we surveyed the applicants and students of specialties from the TOP-50 list. Results of the research: In order to study certain aspects of the sociological portrait of students through the method of questioning of students from the TOP-50 specialties we compiled a sociological questionnaire that included four blocks. The questionnaire for students included 28 questions and the questionnaire for applicants included 33 open and closed questions with the use of different scales with the possibility of selecting several of the listed options and the fields for answers. The results of the questioning of applicants and students are presented; the similarities and differences of the key motives, life plans, values of applicants and students who have chosen perspective professions of secondary vocational education are identified and summarized.

The work carried out a geoecological assessment of the acoustic pollution of the city of Shelekhov, based on the zoning of the territory according to the noise level. Field surveys were carried out and the number of vehicles registered on the city's road network was calculated. With the help of sound level meters, instrumental measurements were made in the daytime and at night, and the daily course of the distribution of the noise level on the main and secondary roads was plotted. In order to identify the propagation range of noise generated by motor vehicles, the sound pressure levels in the city were calculated for daytime and nighttime using the Ecologist Noise program. The results obtained were compared with the established sanitary standards. The result of acoustic monitoring was the creation of maps of the sound pressure level of the territory. Based on noise pollution maps, a set of measures is proposed to prevent and reduce noise impact on the urban environment.

[Display omitted] In this work, a new cathode material for lithium–sulfur (Li–S) batteries was developed. Microporous carbon (with predominant pore size £ 1.2 nm) served as both a matrix for sulfur retention and conductive additive. Microporous carbon was shown to be capable of adsorbing lithium polysulfides thereby suppressing their migration toward lithium anode. The discharge capacity of the S/C composite at the 1st and 20th cycles in Li–S battery operation was 513 and 421 mAh g–1 at a scan rate of 0.1 mV s–1. [ABSTRACT FROM AUTHOR]

Xylan is a polysaccharide found in plant cell walls. It is considered to be a biodegradable polymer, which does not affect negatively the environment. Sulfated xylan derivatives exhibit valuable bioactive properties, in particular, anticoagulant and hypolipidemic. We report on the development of a new method for sulfation of birch wood xylan. Activators of the sulfation reaction with sulfamic acid have been evaluated. Numerical methods have been used to establish the optimum process parameters that ensure the maximum sulfur content in the reaction product. The incorporation of a sulfate group has been confirmed by infrared and nuclear magnetic resonance spectroscopy, and elemental analysis. The initial and sulfated xylans have been comprehensively studied by theoretical methods and the most favorable conformations of the initial xylan and its sulfate have been established. [ABSTRACT FROM AUTHOR]