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2. Nitrogen dioxide pollution increases vulnerability to COVID-19 through altered immune function

Author

Di Ciaula, Agostino, Bonfrate, Leonilde, Portincasa, Piero, Appice, C, Belfiore, A, Binetti, M, Cafagna, G, Campanale, G, Carrieri, A, Cascella, G, Cataldi, S, Cezza, A, Ciannarella, M, Cicala, L, D’Alitto, F, Dell’Acqua, A, Dell’Anna, L, Diaferia, M, Erroi, G, Fiermonte, F, Galerati, I, Giove, M, Grimaldi, L, Mallardi, C, Mastrandrea, E, Mazelli, G. D., Mersini, G, Messina, G, Messina, M, Montesano, A, Noto, A, Novielli, M. E., Noviello, M, Palma, M. V., Palmieri, V. O., Passerini, F, Perez, F, Piro, C, Prigigallo, F, Pugliese, S, Rossi, O, Stasi, C, Stranieri, R, and Vitariello, G

Published
2022
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3. An Unbiased MEMS Capacitance-Controlled Oscillator as a Microphone for HMI Applications

Author

Noviello, M, Quintero, A, De Milleri, N, Wiesbauer, A, Paton, S, Noviello M., Quintero A., De Milleri N., Wiesbauer A., Paton S., Noviello, M, Quintero, A, De Milleri, N, Wiesbauer, A, Paton, S, Noviello M., Quintero A., De Milleri N., Wiesbauer A., and Paton S.

Abstract

MEMS microphones are usually DC biased with a voltage exceeding 10V and a large resistance, requiring a charge pump and a high-ohmic link between the ASIC and the MEMS. This DC biasing is needed to obtain enough sensitivity for medium to high quality microphones. This manuscript inves-tigates capacitance-controlled oscillators which allow to directly connect the MEMS sensor to the oscillator; this solution is prone to scaling. A new type of configuration (referred to as Cross-Connected Sensor) is presented and discussed. Its main advantage is the increase in the sensitivity and, when integrated in an ADC architecture, in the achievable SNR. The proposed solution is intended for Human-Machine Interface applications given their moderate SNR requirements.

Published
2022

4. POS1418 ANTIGEN-SPECIFIC T-CELL DYNAMICS AND MULTIDIRECTIONAL IMMUNE DYSREGULATION IN SLE

Author

Ramirez, G. A., primary, Tassi, E., additional, Noviello, M., additional, Mazzi, B. A., additional, Moroni, L., additional, Sorce, A., additional, Citterio, L., additional, Zagato, L., additional, Tombetti, E., additional, Baldissera, E., additional, Colombo, G., additional, Yacoub, M. R., additional, Bozzolo, E., additional, Bonini, C., additional, Dagna, L., additional, and Manfredi, A., additional

Published
2023
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7. TCR Redirected T Cells for Cancer Treatment: Achievements, Hurdles, and Goals

Author

Manfredi, F, Cianciotti, B, Potenza, A, Tassi, E, Noviello, M, Biondi, A, Ciceri, F, Bonini, C, Ruggiero, E, Manfredi F., Cianciotti B. C., Potenza A., Tassi E., Noviello M., Biondi A., Ciceri F., Bonini C., Ruggiero E., Manfredi, F, Cianciotti, B, Potenza, A, Tassi, E, Noviello, M, Biondi, A, Ciceri, F, Bonini, C, Ruggiero, E, Manfredi F., Cianciotti B. C., Potenza A., Tassi E., Noviello M., Biondi A., Ciceri F., Bonini C., and Ruggiero E.

Abstract

Adoptive T cell therapy (ACT) is a rapidly evolving therapeutic approach designed to harness T cell specificity and function to fight diseases. Based on the evidence that T lymphocytes can mediate a potent anti-tumor response, initially ACT solely relied on the isolation, in vitro expansion, and infusion of tumor-infiltrating or circulating tumor-specific T cells. Although effective in a subset of cases, in the first ACT clinical trials several patients experienced disease progression, in some cases after temporary disease control. This evidence prompted researchers to improve ACT products by taking advantage of the continuously evolving gene engineering field and by improving manufacturing protocols, to enable the generation of effective and long-term persisting tumor-specific T cell products. Despite recent advances, several challenges, including prioritization of antigen targets, identification, and optimization of tumor-specific T cell receptors, in the development of tools enabling T cells to counteract the immunosuppressive tumor microenvironment, still need to be faced. This review aims at summarizing the major achievements, hurdles and possible solutions designed to improve the ACT efficacy and safety profile in the context of liquid and solid tumors.

Published
2020

8. Mother Donors Improve Outcomes after HLA Haploidentical Transplantation: A Study by the Cellular Therapy and Immunobiology Working Party of the European Society for Blood and Marrow Transplantation

Author

Ruggeri, L., Eikema, D. -J., Bondanza, A., Noviello, M., van Biezen, A., de Wreede, L. C., Crucitti, L., Vago, L., Ciardelli, S., Bader, P., Koc, Y., Locatelli, Franco, Veelken, J. H., Gruhn, B., Evans, P., Chabannon, C., Toubert, A., Velardi, A., Locatelli F. (ORCID:0000-0002-7976-3654), Ruggeri, L., Eikema, D. -J., Bondanza, A., Noviello, M., van Biezen, A., de Wreede, L. C., Crucitti, L., Vago, L., Ciardelli, S., Bader, P., Koc, Y., Locatelli, Franco, Veelken, J. H., Gruhn, B., Evans, P., Chabannon, C., Toubert, A., Velardi, A., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Transplacental trafficking of maternal and fetal cells during pregnancy establishes long-term reciprocal microchimerism in both mother and child. Consequently, the maternal immune system may become sensitized to paternal histocompatibility antigens. It has been hypothesized that mother's “exposure” to paternal HLA haplotype antigens during pregnancy may affect the outcome of hematopoietic stem cell transplantation (HSCT) when the mother serves as a donor for the child. In T cell-depleted HLA haploidentical HSCT, maternal donors have been associated with improved transplantation outcomes. The present retrospective multicenter study, conducted on behalf of the Cellular Therapy and Immunobiology Working Party of the European Society of Blood and Marrow Transplantation, involved 409 patients (102 pediatric and 307 adult) with acute leukemia who underwent HLA-haploidentical HSCT. The goal of the study was to evaluate the role of maternal donors in a large cohort of haploidentical transplantation recipients. Transplantation from maternal donors was associated with a lower relapse incidence in T cell-depleted HSCTs (hazard ratio [HR], 2.13; 95% confidence interval [CI], 1.16 to 3.92; P = .018) as well as in a limited series of unmanipulated in vivo T cell-depleted HSCTs (HR, 4.15; 95% CI, 0.94 to 18.35; P = .06), along with better graft-versus-host disease/relapse-free survival (GRFS) in T cell-depleted HSCT (HR, 1.67; 95% CI, 1.02 to 2.73; P = .04). These results indicate that the mother is the preferred donor to provide better GRFS in T cell-depleted HLA-haploidentical HSCT for acute leukemia.

Published
2022

9. Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors

Author

Peccatori, J, Forcina, A, Clerici, D, Crocchiolo, R, Vago, L, Stanghellini, M T L, Noviello, M, Messina, C, Crotta, A, Assanelli, A, Marktel, S, Olek, S, Mastaglio, S, Giglio, F, Crucitti, L, Lorusso, A, Guggiari, E, Lunghi, F, Carrabba, M, Tassara, M, Battaglia, M, Ferraro, A, Carbone, M R, Oliveira, G, Roncarolo, M G, Rossini, S, Bernardi, M, Corti, C, Marcatti, M, Patriarca, F, Zecca, M, Locatelli, F, Bordignon, C, Fleischhauer, K, Bondanza, A, Bonini, C, and Ciceri, F

Published
2015
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10. Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT

Author

Noviello, M, Manfredi, F, Ruggiero, E, Perini, T, Oliveira, G, Cortesi, F, De Simone, P, Toffalori, C, Gambacorta, V, Greco, R, Peccatori, J, Casucci, M, Casorati, G, Dellabona, P, Onozawa, M, Teshima, T, Griffioen, M, Halkes, C, Falkenburg, J, Stolzel, F, Altmann, H, Bornhauser, M, Waterhouse, M, Zeiser, R, Finke, J, Cieri, N, Bondanza, A, Vago, L, Ciceri, F, Bonini, C, Noviello M., Manfredi F., Ruggiero E., Perini T., Oliveira G., Cortesi F., De Simone P., Toffalori C., Gambacorta V., Greco R., Peccatori J., Casucci M., Casorati G., Dellabona P., Onozawa M., Teshima T., Griffioen M., Halkes C. J. M., Falkenburg J. H. F., Stolzel F., Altmann H., Bornhauser M., Waterhouse M., Zeiser R., Finke J., Cieri N., Bondanza A., Vago L., Ciceri F., Bonini C., Noviello, M, Manfredi, F, Ruggiero, E, Perini, T, Oliveira, G, Cortesi, F, De Simone, P, Toffalori, C, Gambacorta, V, Greco, R, Peccatori, J, Casucci, M, Casorati, G, Dellabona, P, Onozawa, M, Teshima, T, Griffioen, M, Halkes, C, Falkenburg, J, Stolzel, F, Altmann, H, Bornhauser, M, Waterhouse, M, Zeiser, R, Finke, J, Cieri, N, Bondanza, A, Vago, L, Ciceri, F, Bonini, C, Noviello M., Manfredi F., Ruggiero E., Perini T., Oliveira G., Cortesi F., De Simone P., Toffalori C., Gambacorta V., Greco R., Peccatori J., Casucci M., Casorati G., Dellabona P., Onozawa M., Teshima T., Griffioen M., Halkes C. J. M., Falkenburg J. H. F., Stolzel F., Altmann H., Bornhauser M., Waterhouse M., Zeiser R., Finke J., Cieri N., Bondanza A., Vago L., Ciceri F., and Bonini C.

Abstract

The major cause of death after allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for acute myeloid leukemia (AML) is disease relapse. We investigated the expression of Inhibitory Receptors (IR; PD-1/CTLA-4/TIM-3/LAG-3/2B4/KLRG1/GITR) on T cells infiltrating the bone marrow (BM) of 32 AML patients relapsing (median 251 days) or maintaining complete remission (CR; median 1 year) after HSCT. A higher proportion of early-differentiated Memory Stem (T SCM ) and Central Memory BM-T cells express multiple IR in relapsing patients than in CR patients. Exhausted BM-T cells at relapse display a restricted TCR repertoire, impaired effector functions and leukemia-reactive specificities. In 57 patients, early detection of severely exhausted (PD-1 + Eomes + T-bet − ) BM-T SCM predicts relapse. Accordingly, leukemia-specific T cells in patients prone to relapse display exhaustion markers, absent in patients maintaining long-term CR. These results highlight a wide, though reversible, immunological dysfunction in the BM of AML patients relapsing after HSCT and suggest new therapeutic opportunities for the disease.

Published
2019

12. Beneficial role of CD8+T-cell reconstitution after HLA-haploidentical stem cell transplantation for high-risk acute leukaemias

Author

Bondanza, A., Ruggeri, L., Noviello, M., Eikema, D.J., Bonini, C., Chabannon, C., Werf, S. van der, Biezen, A. van, Wreede, L.C. de, Crucitti, L., Vago, L., Merluzzi, M., Massei, M.S., Veelken, H., Koc, Y., Bader, P., Gruhn, B., Locatelli, F., Ciceri, F., Toubert, A., Velardi, A., Bernardo, M.E., Dazzi, F., Ellard, R., Fleischhauer, K., Greco, R., Hudecek, M., Kohl, U., Kuball, J., Malard, F., Pedrazzoli, P., Rocha, V., Ruggeri, A., Urbano-Ispizua, A., Wang, J.F., Wieten, L., EBMT Cell Therapy Immunobiol Worki, Bondanza, Attilio, Ruggeri, Loredana, Noviello, Maddalena, Eikema, Dirk-Jan, Bonini, Chiara, Chabannon, Christian, van der Werf, Steffie, van Biezen, Anja, de Wreede, Liesbeth C., Crucitti, Lara, Vago, Luca, Merluzzi, Mara, Massei, Maria Speranza, Veelken, Hendrik, Koc, Yener, Bader, Peter, Gruhn, Bernd, Locatelli, Franco, Ciceri, Fabio, Toubert, Antoine, Velardi, Andrea, MUMC+: DA TI Laboratorium (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and MUMC+: DA TI Staf (9)

Subjects
Male, Oncology, BLOOD, COUNT, Medizin, CHILDREN, CD8-Positive T-Lymphocytes, DISEASE, 0302 clinical medicine, Risk Factors, hemic and lymphatic diseases, Cytotoxic T cell, Registries, Child, INDEX, Leukemia, Hematology, Middle Aged, RECOVERY, Haematopoiesis, surgical procedures, operative, medicine.anatomical_structure, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Transplantation, Child, Preschool, 030220 oncology & carcinogenesis, HSCT, Female, Stem cell, Adult, medicine.medical_specialty, Adolescent, T cell, Human leukocyte antigen, Young Adult, 03 medical and health sciences, CD8-positive T-lymphocytes, haematopoietic stem cell transplantation, risk factors, Internal medicine, SCORE, medicine, Humans, IMMUNOTHERAPY, Aged, business.industry, ADULTS, BONE-MARROW-TRANSPLANTATION, Transplantation, Haploidentical, business, CD8, Stem Cell Transplantation, 030215 immunology, RESPONSES
Abstract

HLA-haploidentical haematopoietic stem cell transplantation (haplo-HSCT) is increasingly offered to patients with high-risk acute leukaemia. Unfortunately, haplo-HSCT is followed by a delayed immunoreconstitution. The aim of this EBMT registry study was to explore the clinical impact of lymphocyte subset counts after haplo-HSCT. We considered 144 leukaemic patients transplanted in the period 2001-2012. Pre-transplantation clinical variables and differential immune-cell counts (CD3, CD4, CD8 T cells, NK and B cells) measured before day 100 were evaluated for their capacity to predict overall survival, relapse mortality or non-relapse mortality (NRM). Negative prognostic factors for overall survival were advanced disease state at transplantation, host age and CMV seropositivity. Higher CD3, CD4 and CD8 counts were associated with a better overall survival and a lower NRM. Strikingly, when tested in multivariable analysis, higher CD3 and CD8 counts were still significantly associated with a lower NRM. These results indicate that an accelerated T-cell reconstitution correlates with less transplantation mortality, likely due to the protective role of T cells against viral infections. This observation suggests that CD8+ T-cell counts should be investigated as surrogate biomarkers of outcome in prospective haplo-HSCT trials.

Published
2019

21. Rapamycin-based GvHD prophylaxis after T-cell replete unmanipulated haploidentical peripheral stem cell transplantation for advanced leukaemias: preliminary results of the TrRaMM study: O171

Author

Peccatori, J., Clerici, D., Forcina, A., Messina, C., Stanghellini, Lupo M.T., Noviello, M., Valtolina, V., Giorgiani, G., Crocchiolo, R., Marcatti, M., Mastaglio, S., Assanelli, A., Guggiari, E., Crotta, A., Gattillo, S., Rossini, S., Corti, C., Bernardi, M., Locatelli, F., Bonini, C., and Ciceri, F.

Published
2009

23. Beneficial role of CD8+ T-cell reconstitution after HLA-haploidentical stem cell transplantation for high-risk acute leukaemias: results from a clinico-biological EBMT registry study mostly in the T-cell-depleted setting

Author

Bondanza, A., Ruggeri, L., Noviello, M., Eikema, D. -J., Bonini, C., Chabannon, C., van der Werf, S., van Biezen, A., de Wreede, L. C., Crucitti, L., Vago, L., Merluzzi, M., Massei, M. S., Veelken, H., Koc, Y., Bader, P., Gruhn, B., Locatelli, Franco, Ciceri, F., Toubert, A., Velardi, A., Locatelli F. (ORCID:0000-0002-7976-3654), Bondanza, A., Ruggeri, L., Noviello, M., Eikema, D. -J., Bonini, C., Chabannon, C., van der Werf, S., van Biezen, A., de Wreede, L. C., Crucitti, L., Vago, L., Merluzzi, M., Massei, M. S., Veelken, H., Koc, Y., Bader, P., Gruhn, B., Locatelli, Franco, Ciceri, F., Toubert, A., Velardi, A., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

HLA-haploidentical haematopoietic stem cell transplantation (haplo-HSCT) is increasingly offered to patients with high-risk acute leukaemia. Unfortunately, haplo-HSCT is followed by a delayed immunoreconstitution. The aim of this EBMT registry study was to explore the clinical impact of lymphocyte subset counts after haplo-HSCT. We considered 144 leukaemic patients transplanted in the period 2001–2012. Pre-transplantation clinical variables and differential immune-cell counts (CD3, CD4, CD8 T cells, NK and B cells) measured before day 100 were evaluated for their capacity to predict overall survival, relapse mortality or non-relapse mortality (NRM). Negative prognostic factors for overall survival were advanced disease state at transplantation, host age and CMV seropositivity. Higher CD3, CD4 and CD8 counts were associated with a better overall survival and a lower NRM. Strikingly, when tested in multivariable analysis, higher CD3 and CD8 counts were still significantly associated with a lower NRM. These results indicate that an accelerated T-cell reconstitution correlates with less transplantation mortality, likely due to the protective role of T cells against viral infections. This observation suggests that CD8+ T-cell counts should be investigated as surrogate biomarkers of outcome in prospective haplo-HSCT trials.

Published
2019

24. HHV6 Specific T-cells are Predictor of Clinically Relevant HHV6 Infection after Allogeneic HSCT

Author

Greco R, Noviello M, Crucitti L, Racca S, Valtolina V, Pozzato M, Morelli M, Giglio F, Mannina D, Barbanti MC, Forcina A, Rolla S, Assanelli A, Carrabba M, Marktel S, Bernardi M, Corti C, Stanghellini MTL, Vago L, Peccatori J, Clementi M, Bonini C, Ciceri F, Greco, R, Noviello, M, Crucitti, L, Racca, S, Valtolina, V, Pozzato, M, Morelli, M, Giglio, F, Mannina, D, Barbanti, Mc, Forcina, A, Rolla, S, Assanelli, A, Carrabba, M, Marktel, S, Bernardi, M, Corti, C, Stanghellini, Mtl, Vago, L, Peccatori, J, Clementi, M, Bonini, C, and Ciceri, F

Published
2016

25. Early recovery of CMV-specific T cells after HLA-haploidentical HSCT with post-transplant cyclophosphamide is associated with a reduced risk of severe infections: a validation study

Author

Noviello M, Greco R, Valtolina V, Forcina A, Pozzato M, Staghellini MTL, Giglio F, Morelli M, Assanelli A, Dalto SC, Piemontese S, Bernardi M, Corti C, Vago L, Cieri N, Peccatori J, Bonini C, Bondanza A, Ciceri F, Noviello, M, Greco, R, Valtolina, V, Forcina, A, Pozzato, M, Staghellini, Mtl, Giglio, F, Morelli, M, Assanelli, A, Dalto, Sc, Piemontese, S, Bernardi, M, Corti, C, Vago, L, Cieri, N, Peccatori, J, Bonini, C, Bondanza, A, and Ciceri, F

Published
2016

26. T-cell immune reconstitution predicts the outcome of Human Herpes Virus 6 Infection in 54 Patients after Allogeneic Hematopoietic Stem Cell Transplantation

Author

Greco R, Crucitti L, Noviello M, Racca S, Barbanti MC, Valtolina V, Dvir R, Vago L, Stanghellini MTL, Giglio F, Morelli M, Rolla S, Lorentino F, Orsini A, Forcina A, Assanelli A, Carrabba M, Marktel S, Bernardi M, Corti C, Peccatori J, Bonini C, Clementi M, Ciceri F, Greco, R, Crucitti, L, Noviello, M, Racca, S, Barbanti, Mc, Valtolina, V, Dvir, R, Vago, L, Stanghellini, Mtl, Giglio, F, Morelli, M, Rolla, S, Lorentino, F, Orsini, A, Forcina, A, Assanelli, A, Carrabba, M, Marktel, S, Bernardi, M, Corti, C, Peccatori, J, Bonini, C, Clementi, M, and Ciceri, F

Published
2015

27. Long-term immunological profile of patients treated with haploidentical HSCT and TK-cells to unravel the requirements of memory T cell persistence

Author

Oliveira G, Stanghellini MTL, Cieri N, D'Agostino M, Ruggiero E, Greco R, Mastaglio S, Noviello M, Vago L, Biasco L, Bondanza A, Aiuti A, Lambiase A, Schmidt M, Traversari C, Von Kalle C, Ciceri F, Bordignon C, Bonini C, Oliveira, G, Stanghellini, Mtl, Cieri, N, D'Agostino, M, Ruggiero, E, Greco, R, Mastaglio, S, Noviello, M, Vago, L, Biasco, L, Bondanza, A, Aiuti, A, Lambiase, A, Schmidt, M, Traversari, C, Von Kalle, C, Ciceri, F, Bordignon, C, and Bonini, C

Published
2015

28. Human Herpes Virus 6 Encephalitis: a major challenge after Haploidentical Hematopoietic Stem Cell Transplantation

Author

Greco R, Noviello M, Vago L, Stanghellini MTL, Cieri N, Oliveira G, Giglio F, Morelli M, Valtolina V, Barbanti MC, Lorentino F, Crucitti L, Orsini A, Forcina A, Assanelli A, Carrabba M, Marktel S, Bernardi M, Corti C, Peccatori J, Bordignon C, Bonini C, Ciceri F, Greco, R, Noviello, M, Vago, L, Stanghellini, Mtl, Cieri, N, Oliveira, G, Giglio, F, Morelli, M, Valtolina, V, Barbanti, Mc, Lorentino, F, Crucitti, L, Orsini, A, Forcina, A, Assanelli, A, Carrabba, M, Marktel, S, Bernardi, M, Corti, C, Peccatori, J, Bordignon, C, Bonini, C, and Ciceri, F

Published
2015

30. Long-Term Immunological Profile of Patients Treated with Haploidentical HSCT and TK-Cells to Study the Requirements of Memory T Cell Persistence

Author

Oliveira G, Stanghellini MTL, Ruggiero E, Cieri N, D'Agostino M, Greco R, Mastaglio S, Noviello M, Vago L, Biasco L, Bondanza A, Aiuti A, Lambiase A, Schmidt M, Traversari C, von Kalle C, Ciceri F, Bordignon C, Bonini C, Oliveira, G, Stanghellini, Mtl, Ruggiero, E, Cieri, N, D'Agostino, M, Greco, R, Mastaglio, S, Noviello, M, Vago, L, Biasco, L, Bondanza, A, Aiuti, A, Lambiase, A, Schmidt, M, Traversari, C, von Kalle, C, Ciceri, F, Bordignon, C, and Bonini, C

Published
2014

31. Revealing the Generation of Human Memory Stem T Cells in Haploidentical T-Replete Hematopoietic Stem Cell Transplantation

Author

Cieri N, Oliveira G, Greco R, Forcato M, Taccioli C, Valtolina V, Noviello M, Vago L, Bondanza A, Lunghi F, Marktel S, Bellio L, Bordignon C, Bicciato S, Peccatori J, Ciceri F, Bonini C, Cieri, N, Oliveira, G, Greco, R, Forcato, M, Taccioli, C, Valtolina, V, Noviello, M, Vago, L, Bondanza, A, Lunghi, F, Marktel, S, Bellio, L, Bordignon, C, Bicciato, S, Peccatori, J, Ciceri, F, and Bonini, C

Published
2014

32. Long term persistence of TK-cells and dynamics of memory T cells in patients treated with suicide gene therapy for hematological malignancies

Author

Oliveira G, Stanghellini MTL, Ruggiero E, Cieri N, D'Agostino M, Greco R, Mastaglio S, Noviello M, Vago L, Biasco L, Bondanza A, Aiuti A, Schmidt M, Traversari C, Von Kalle C, Ciceri F, Bordignon C, Bonini C, Oliveira, G, Stanghellini, Mtl, Ruggiero, E, Cieri, N, D'Agostino, M, Greco, R, Mastaglio, S, Noviello, M, Vago, L, Biasco, L, Bondanza, A, Aiuti, A, Schmidt, M, Traversari, C, Von Kalle, C, Ciceri, F, Bordignon, C, and Bonini, C

Published
2014

33. TRACKING T CELL DYNAMICS IN THE FIRST MONTH AFTER ALLOGENEIC HSCT OFFERS A UNIQUE OPPORTUNITY TO UNVEIL THE MECHANISM OF MEMORY STEM T CELL FORMATION IN HUMANS

Author

Cieri, N, Peccatori, J, Oliveira, G, Greco, R, Taccioli, C, Forcato, M, Noviello, M, Valtolina, V, Bondanza, A, Morelli, M, Lunghi, F, Marktel, S, Bellio, L, Bicciato, S, Ciceri, F, Bonini, C, Cieri, N, Peccatori, J, Oliveira, G, Greco, R, Taccioli, C, Forcato, M, Noviello, M, Valtolina, V, Bondanza, A, Morelli, M, Lunghi, F, Marktel, S, Bellio, L, Bicciato, S, Ciceri, F, and Bonini, C

Published
2014

34. LONG-TERM IMMUNOLOGICAL PROFILE AND T CELL DYNAMICS IN PATIENTS TREATED WITH ALLOGENEIC TRANSPLANTATION AND TK-CELLS FOR HEMATOLOGICAL MALIGNANCIES

Author

Oliveira G, Stanghellini MTL, Cieri N, Greco R, D'Agostino M, Noviello M, Valtolina V, Vago L, Bondanza A, Traversari C, Ruggiero E, Paruzynski A, Schmidt M, Von Kalle C, Ciceri F, Bordignon C, Bonini C, Oliveira, G, Stanghellini, Mtl, Cieri, N, Greco, R, D'Agostino, M, Noviello, M, Valtolina, V, Vago, L, Bondanza, A, Traversari, C, Ruggiero, E, Paruzynski, A, Schmidt, M, Von Kalle, C, Ciceri, F, Bordignon, C, and Bonini, C

Published
2014

35. HUMAN HERPES VIRUS 6 AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

Author

Greco R, Lorentino F, Crucitti L, Vago L, Stanghellini MTL, Forcina A, Giglio F, Morelli M, Levati G, Orsini A, Carbone MR, Valtolina V, Noviello M, Marktel S, Assanelli A, Carrabba M, Marcatti M, Peccatori J, Bernardi M, Bonini C, Corti C, Ciceri F, Greco, R, Lorentino, F, Crucitti, L, Vago, L, Stanghellini, Mtl, Forcina, A, Giglio, F, Morelli, M, Levati, G, Orsini, A, Carbone, Mr, Valtolina, V, Noviello, M, Marktel, S, Assanelli, A, Carrabba, M, Marcatti, M, Peccatori, J, Bernardi, M, Bonini, C, Corti, C, and Ciceri, F

Published
2014

38. Long-Term Immunological Profile and T Cell Dynamics In Patients Treated With Allogeneic Transplantation and TK-Cells For Hematological Malignancies

Author

Oliveira G, Stanghellini MTL, Cieri N, Greco R, Noviello M, Valtolina V, Vago L, Traversari C, Ruggiero E, Paruzynski A, Schmidt M, von Kalle C, Ciceri F, Bordignon C, Bonini C, Oliveira, G, Stanghellini, Mtl, Cieri, N, Greco, R, Noviello, M, Valtolina, V, Vago, L, Traversari, C, Ruggiero, E, Paruzynski, A, Schmidt, M, von Kalle, C, Ciceri, F, Bordignon, C, and Bonini, C

Published
2013

41. Early reconstitution of functional CMV immunity predicts a low risk for viral reactivation after HLA-haploidentical haematopoietic stem cell transplantation

Author

Noviello M, Forcina A, Lupo Stanghellini MT, Carrabba M, Assanelli A, Carbone MR, Magnani Z, Peccatori J, Bernardi M, Corti C, CICERI , FABIO, BONINI , MARIA CHIARA, BONDANZA , ATTILIO, Noviello, M, Forcina, A, Lupo Stanghellini, Mt, Carrabba, M, Assanelli, A, Carbone, Mr, Magnani, Z, Peccatori, J, Bernardi, M, Corti, C, Ciceri, Fabio, Bonini, MARIA CHIARA, and Bondanza, Attilio

Published
2012

43. Mechanisms of thymic renewal after Infusion of suicide gene-modified donor T cellsafter hematopoietic stem cell transplantation (HSCT) in adult patients

Author

BORDIGNON, CLAUDIO, Vago L, Oliveira G, Noviello M, Soldati C, Ghio D, Brigida I, Aiuti A, Lupo-stanghellini Mt, Peccatori J, Lambiase A, DEL MASCHIO, ALESSANDRO, CICERI, FABIO, Bonini C., BONDANZA , ATTILIO, Bordignon, Claudio, Vago, L, Oliveira, G, Noviello, M, Soldati, C, Ghio, D, Brigida, I, Aiuti, A, Lupo-stanghellini, Mt, Peccatori, J, Lambiase, A, Bondanza, Attilio, DEL MASCHIO, Alessandro, Ciceri, Fabio, and Bonini, C.

Published
2011

44. T Cell Suicide Gene Therapy Prompts Thymic Renewal in Adults After Haploidentical Hematopoietic Stem Cell Transplantation in the Absence of Post-Transplant Immunesuppression

Author

Vago L, Oliveira G, Noviello M, Soldati C, Ghio D, Brigida I, Greco R, Lupo-stanghellini Mt, Peccatori J, Fracchia S, Del Fiacco M, Traversari C, Aiuti A, Lambiase A, DEL MASCHIO, ALESSANDRO, BONDANZA , ATTILIO, BORDIGNON, CLAUDIO, CICERI, FABIO, BONINI , MARIA CHIARA, Vago, L, Oliveira, G, Bondanza, Attilio, Noviello, M, Soldati, C, Ghio, D, Brigida, I, Greco, R, Lupo-stanghellini, Mt, Peccatori, J, Fracchia, S, Del Fiacco, M, Traversari, C, Aiuti, A, Lambiase, A, DEL MASCHIO, Alessandro, Bordignon, Claudio, Ciceri, Fabio, and Bonini, MARIA CHIARA

Published
2011

45. The infusion of suicide gene-modified donor T cells after hematopoietic stem cell transplantation prompts thymic renewal in adult patients by an IL-7 dependent mechanism

Author

Oliveira G, Vago L, Noviello M, Soldati C, Ghio D, Brigida I, Aiuti A, Stanghellini MTL, Peccatori J, Bondanza A, Del Maschio A, Bordignon C, Ciceri F, Bonini C, Oliveira, G, Vago, L, Noviello, M, Soldati, C, Ghio, D, Brigida, I, Aiuti, A, Stanghellini, Mtl, Peccatori, J, Bondanza, A, Del Maschio, A, Bordignon, C, Ciceri, F, and Bonini, C

Published
2011

46. Thymic Renewal and Anti-Leukemic Effect In Adults After Haploidentical Transplantation and Donor T Cell Suicide Gene Therapy

Author

Vago L, Oliveira G, Noviello M, Soldati C, Ghio D, Nicoletti R, Brigida I, Aiuti A, Stanghellini MT Lupo, Mastaglio S, Greco R, Lambiase A, Peccatori J, BONDANZA , ATTILIO, Fleischhauer K, BORDIGNON, CLAUDIO, CICERI, FABIO, BONINI , MARIA CHIARA, Vago, L, Oliveira, G, Noviello, M, Soldati, C, Ghio, D, Nicoletti, R, Brigida, I, Aiuti, A, Stanghellini MT, Lupo, Mastaglio, S, Greco, R, Lambiase, A, Peccatori, J, Bondanza, Attilio, Fleischhauer, K, Bordignon, Claudio, Ciceri, Fabio, and Bonini, MARIA CHIARA

Published
2010

47. Thymic renewal in adult leukaemia patients after haplodentical stem cell transplantation and infusion of suicide gene-modified donor T-cells

Author

Vago L, Oliveira G, Noviello M, Soldati C, Nicoletti R, Brigida I, Aiuti A, Stanghellini MT Lupo, Peccatori J, BONDANZA , ATTILIO, BORDIGNON, CLAUDIO, CICERI, FABIO, BONINI , MARIA CHIARA, Vago, L, Oliveira, G, Noviello, M, Soldati, C, Nicoletti, R, Brigida, I, Aiuti, A, Stanghellini MT, Lupo, Peccatori, J, Bondanza, Attilio, Bordignon, Claudio, Ciceri, Fabio, and Bonini, MARIA CHIARA

Published
2010

48. Thymic renewal and anti-leukemic effect in adults after haplodentical transplantation and suicide gene therapy

Author

Vago L, Oliveira G, Noviello, M, Soldati C, Ghio D, Nicoletti R, Brigida I, Aiuti A, Lupo Stanghellini MT, Peccatori J, BONDANZA , ATTILIO, Fleischhauer K, BORDIGNON, CLAUDIO, CICERI, FABIO, BONINI , MARIA CHIARA, Vago, L, Oliveira, G, Noviello, M, Soldati, C, Ghio, D, Nicoletti, R, Brigida, I, Aiuti, A, Lupo Stanghellini, Mt, Peccatori, J, Bondanza, Attilio, Fleischhauer, K, Bordignon, Claudio, Ciceri, Fabio, and Bonini, MARIA CHIARA

Published
2010

49. In-vivo T-regs generation by rapamycin-mycophenolate-ATG as a new platform for GvHD prophylaxis in T-cell repleted unmanipulated haploidentical peripheral stem cell transplantation: results in 59 patients

Author

Peccatori J, Clerici D, Forcina A, Bemardi M, Crocchiolo R, Messina C, Noviello M, Mastaglio S, Giglio F, Malato S, Stanghelllini MTL, Marktel S, Assanelli A, BATTAGLIA, MARCO MARIA, Ferraro A, Rossini S, Bernardo ME, BONDANZA, ATTILIO, Roncarolo MG, BONINI , MARIA CHIARA, Locatelli F, CICERI, FABIO, Peccatori, J, Clerici, D, Forcina, A, Bemardi, M, Crocchiolo, R, Messina, C, Noviello, M, Mastaglio, S, Giglio, F, Malato, S, Stanghelllini, Mtl, Marktel, S, Assanelli, A, Battaglia, MARCO MARIA, Ferraro, A, Rossini, S, Bernardo, Me, Bondanza, Attilio, Roncarolo, Mg, Bonini, MARIA CHIARA, Locatelli, F, and Ciceri, Fabio

Published
2010

50. Thymic renewal in adults after haploidentical hematopoietic stem cell transplantation and suicide gene therapy

Author

Oliveira G, Vago L, Noviello M, Soldati C, Ghio D, Nicoletti R, Brigida I, Aiuti A, Stanghellini MTL, Peccatori J, Fleischhauer K, BONDANZA , ATTILIO, BORDIGNON, CLAUDIO, CICERI, FABIO, BONINI , MARIA CHIARA, Oliveira, G, Vago, L, Noviello, M, Soldati, C, Ghio, D, Nicoletti, R, Brigida, I, Aiuti, A, Stanghellini, Mtl, Peccatori, J, Bondanza, Attilio, Fleischhauer, K, Bordignon, Claudio, Ciceri, Fabio, and Bonini, MARIA CHIARA

Published
2010

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