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2. Prevalence of pulmonary embolism among patients with recent onset of dyspnea on exertion. A cross-sectional study

Author

Prandoni, Paolo, Lensing, Anthonie W.A., Prins, Martin H., Ciammaichella, Maurizio, Pirillo, Silvana, Pace, Federica, Zalunardo, Beniamino, Bottino, Fabrizio, Ageno, Walter, Muiesan, Maria L., Forlin, Marco, Depietri, Luca, Bova, Carlo, Costantini, Nicoletta, Caviglioli, Cosimo, Migliaccio, Ludovica, Noventa, Franco, Levi, Marcel, Davidson, Bruce L., and Palareti, Gualtiero

Published
2023
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5. Renal safety in 3264 HCV patients treated with DAA-based regimens: Results from a large Italian real-life study

Author

D’Ambrosio, Roberta, Pasulo, Luisa, Giorgini, Alessia, Spinetti, Angiola, Messina, Emanuela, Fanetti, Ilaria, Puoti, Massimo, Aghemo, Alessio, Viganò, Paolo, Vinci, Maria, Menzaghi, Barbara, Lombardi, Andrea, Pan, Angelo, Pigozzi, Marie Graciella, Grossi, Paolo, Lazzaroni, Sergio, Spinelli, Ombretta, Invernizzi, Pietro, Maggiolo, Franco, Terreni, Natalia, Monforte, Antonella D’Arminio, Poggio, Paolo Del, Taddei, Maria Teresa, Colombo, Silvia, Pozzoni, Pietro, Molteni, Chiara, Brocchieri, Alessandra, Bhoori, Sherrie, Buscarini, Elisabetta, Centenaro, Riccardo, Mendeni, Monia, Colombo, Alberto Eraldo, Di Marco, Mariella, Dionigi, Elena, Bella, Daniele, Borghi, Marta, Zuin, Massimo, Zaltron, Serena, Noventa, Franco, Annalisa, De Silvestri, Lampertico, Pietro, and Fagiuoli, Stefano

Published
2020
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6. The QR-max index, a novel electrocardiographic index for the determination of left ventricular conduction delay and selection of cardiac resynchronization in patients with non-left bundle branch block

Author

Pastore, Gianni, Maines, Massimiliano, Marcantoni, Lina, Lanza, Daniela, Zanon, Francesco, Noventa, Franco, Corbucci, Giorgio, Rigatelli, Gianluca, Baracca, Enrico, Zuin, Marco, Picariello, Claudio, Carraro, Mauro, Conte, Luca, Roncon, Loris, and Barold, S. Serge

Published
2020
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7. Real-life effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in hepatitis C patients with previous DAA failure

Author

Degasperi, Elisabetta, Spinetti, Angiola, Lombardi, Andrea, Landonio, Simona, Rossi, Maria Cristina, Pasulo, Luisa, Pozzoni, Pietro, Giorgini, Alessia, Fabris, Paolo, Romano, Antonietta, Lomonaco, Lorenzo, Puoti, Massimo, Vinci, Maria, Gatti, Federico, Carolo, Giada, Zoncada, Alessia, Bonfanti, Paolo, Russo, Francesco Paolo, Aghemo, Alessio, Soria, Alessandro, Centenaro, Riccardo, Maggiolo, Franco, Rovere, Pierangelo, Pasin, Francesca, Paon, Veronica, Faggiano, Giovanni, Vario, Alessandro, Grossi, Glenda, Soffredini, Roberta, Carriero, Canio, Paolucci, Stefania, Noventa, Franco, Alberti, Alfredo, Lampertico, Pietro, and Fagiuoli, Stefano

Published
2019
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8. Real-world effectiveness and safety of glecaprevir/pibrentasvir in 723 patients with chronic hepatitis C

Author

D'Ambrosio, Roberta, Pasulo, Luisa, Puoti, Massimo, Vinci, Maria, Schiavini, Monica, Lazzaroni, Sergio, Soria, Alessandro, Gatti, Federico, Menzaghi, Barbara, Aghemo, Alessio, Capelli, Francesca, Rumi, Maria Grazia, Morini, Lorenzo, Giorgini, Alessia, Pigozzi, Marie Graciella, Rossini, Angelo, Maggiolo, Franco, Pan, Angelo, Memoli, Massimo, Spinelli, Ombretta, Del Poggio, Paolo, Saladino, Valeria, Spinetti, Angiola, De Bona, Anna, Capretti, Andrea, Uberti-Foppa, Caterina, Bonfanti, Paolo, Terreni, Natalia, Menozzi, Fernanda, Colombo, Alberto Eraldo, Giglio, Omar, Centenaro, Riccardo, Borghi, Marta, Baiguera, Chiara, Picciotto, Viviana, Landonio, Simona, Gori, Andrea, Magnani, Carlo, Noventa, Franco, Paolucci, Stefania, Lampertico, Pietro, and Fagiuoli, Stefano

Published
2019
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9. Newly diagnosed hepatocellular carcinoma in patients with advanced hepatitis C treated with DAAs: A prospective population study

Author

Romano, Antonietta, Angeli, Paolo, Piovesan, Sara, Noventa, Franco, Anastassopoulos, Georgios, Chemello, Liliana, Cavalletto, Luisa, Gambato, Martina, Russo, Francesco Paolo, Burra, Patrizia, Vincenzi, Valter, Scotton, Pier Giorgio, Panese, Sandro, Tempesta, Diego, Bertin, Tosca, Carrara, Maurizio, Carlotto, Antonio, Capra, Franco, Carolo, Giada, Scroccaro, Giovanna, and Alberti, Alfredo

Published
2018
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17. Safety and Efficacy of Rivaroxaban as Extended-Phase Anticoagulation in Patients with Cancer and Venous Thromboembolism: A Preliminary Data Analysis from the Mac Project

Author

Bernardi, Enrico, primary, Camporese, Giuseppe, additional, Bortoluzzi, Cristiano, additional, Noventa, Franco, additional, Ceccato, Davide, additional, Tonello, Chiara, additional, Vohong, Stefania, additional, Campello, Elena, additional, Simion, Chiara, additional, Imbalzano, Egidio, additional, Di Micco, Pierpaolo, additional, Callegari, Elena, additional, and Simioni, Paolo, additional

Published
2022
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18. Safety and Efficacy of Rivaroxaban for Extended-Phase Anticoagulation of Patients with Unprovoked or Recurrent Venous Thromboembolism: Real-Life Data from the MAC Project

Author

Bortoluzzi, Cristiano, primary, Bernardi, Enrico, additional, Camporese, Giuseppe, additional, Noventa, Franco, additional, Ceccato, Davide, additional, Tonello, Chiara, additional, Vo Hong, Ngoc, additional, Campello, Elena, additional, Simion, Chiara, additional, Imbalzano, Egidio, additional, Di Micco, Pierpaolo, additional, Callegari, Elena, additional, and Simioni, Paolo, additional

Published
2022
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19. The PhysioVP-AF study, a randomized controlled trial to assess the clinical benefit of physiological ventricular pacing vs. managed ventricular pacing for persistent atrial fibrillation prevention in patients with prolonged atrioventricular conduction: design and rationale

Author

Pastore, Gianni, Bertini, Matteo, Bonanno, Carlo, Coluccia, Giovanni, Dell'Era, Gabriele, Mattia, Luca De, Grieco, Domenico, Katsouras, Grigorius, Maines, Massimiliano, Marcantoni, Lina, Marinaccio, Leonardo, Paglino, Gabriele, Palmisano, Pietro, Ziacchi, Matteo, Zoppo, Franco, and Noventa, Franco

Abstract

Aims In patients with prolonged atrioventricular (AV) conduction and pacemaker (PM) indication due to sinus node disease (SND) or intermittent AV-block who do not need continuous ventricular pacing (VP), it may be difficult to determine which strategy to adopt. Currently, the standard of care is to minimize unnecessary VP by specific VP avoidance (VPA) algorithms. The superiority of this strategy over standard DDD or DDD rate-responsive (DDD/DDDR) in improving clinical outcomes is controversial, probably owing to the prolongation of the atrialventricular conduction (PR interval) caused by the algorithms. Conduction system pacing (CSP) may offer the most physiological-VP approach, providing appropriate AV conduction and preventing pacing-induced dyssynchrony. Methods and results PhysioVP-AF is a prospective, controlled, randomized, single-blind trial designed to determine whether atrial-synchronized conduction system pacing (DDD-CSP) is superior to standard DDD-VPA pacing in terms of 3-year reduction of persistent-AF occurrence. Cardiovascular hospitalization, quality-of-life, and safety will be evaluated. Patients with indication for permanent DDD pacing for SND or intermittent AV-block and prolonged AV conduction (PR interval > 180 ms) will be randomized (1:1 ratio) to DDD-VPA (VPA-algorithms ON, septal/apex position) or to DDD-CSP (His bundle or left bundle branch area pacing, AV-delay setting to control PR interval, VPA-algorithms OFF). Approximately 400 patients will be randomized in 24 months in 13 Italian centres. Conclusion The PhysioVP-AF study will provide an essential contribution to patient management with prolonged AV conduction and PM indication for sinus nodal disease or paroxysmal 2nd-degree AV-block by determining whether CSP combined with a controlled PR interval is superior to standard management that minimizes unnecessary VP in terms of reducing clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Serial-2 point ultrasonography plus D-dimer vs whole-leg color-coded Doppler ultrasonography for diagnosing suspected symptomatic deep vein

Author

Cogo, Alberto, Camporese, Giuseppe, Buller, Harry R., Imberti, Davide, Berchio, Arrigo, Ghirarduzzi, Angelo, Verlato, Fabio, Anastasio, Raffaela, Prati, Carolina, Piccioli, Andrea, Pesavento, Raffaele, Bova, Carlo, Maltempi, Patrizia, Zanatta, Nello, Cappelli, Roberto, Bucherini, Eugenio, Cuppini, Stefano, Noventa, Franco, and Prandoni, Paolo

Subjects
Venous thrombosis -- Diagnosis, Venous thrombosis -- Care and treatment, Ultrasound imaging -- Usage, Ultrasound imaging -- Health aspects
Abstract

A study was conducted to investigate whether 2 diagnostic strategies are the same for management of symptomatic outpatients with suspected Deep vein thrombosis (DVT) of the lower extremities. Results indicated that 2 diagnostic strategies were equivalent for management of symptomatic outpatients with suspected DVT of lower extremities.

Published
2008

33. MAC Project—Monitoring Anticoagulant Therapy Observational Study: Rationale and Protocol

Author

Camporese, Giuseppe, primary, Bernardi, Enrico, additional, Bortoluzzi, Cristiano, additional, Noventa, Franco, additional, Hong, Ngoc Vo, additional, Callegari, Elena, additional, Villalta, Sabina, additional, Tonello, Chiara, additional, Nardin, Michela, additional, Campello, Elena, additional, Spiezia, Luca, additional, and Simioni, Paolo, additional

Published
2021
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34. Occurrence of persistent atrial fibrillation during pacing for sinus node disease: The influence of His bundle pacing versus managed ventricular pacing

Author

Pastore, Gianni, primary, Marcantoni, Lina, additional, Lanza, Daniela, additional, Maines, Massimiliano, additional, Noventa, Franco, additional, Corbucci, Giorgio, additional, Rigatelli, Gianluca, additional, Baracca, Enrico, additional, Roncon, Loris, additional, and Zanon, Francesco, additional

Published
2020
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35. Impact if HBV infection in HCV/HBV coinfected patients treated with DAAs in north Italy

Author

Fabris, Paolo, primary, Noventa, Franco, additional, Fagiuoli, Stefano, additional, Farina, Francesca, additional, Carolo, Giada, additional, Carlotto, Antonio, additional, Rovere, Pierangelo, additional, Cavinato, Silvia, additional, Romano, Antonietta, additional, Vario, Alessandro, additional, Franceschet, Irene, additional, Panese, sandro, additional, Bertin, Tosca, additional, Zappalà, Francesco, additional, Alberti, Alfredo, additional, Lobello, Salvatore, additional, Aghemo, Alessio, additional, Bruno, Raffaele, additional, Puoti, Massimo, additional, Rizzardini, Giuliano, additional, Spinelli, Ombretta, additional, Pigozzi, Marie Graciella, additional, Spinetti, Angiola, additional, Menzaghi, Barbara, additional, Pan, Angelo, additional, Bella, Daniele, additional, Re, Tiziana, additional, Borghi, Marta, additional, Lombardi, Andrea, additional, Viganò, Mauro, additional, Salpietro, Stefania, additional, Lleo, Ana, additional, and Del Punta, Veronica, additional

Published
2020
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36. Comparison of three therapeutic regimens for genotype‐3 hepatitis C virus infection in a large real‐life multicentre cohort

Author

Soria, Alessandro, primary, Fava, Marco, additional, Bernasconi, Davide P., additional, Lapadula, Giuseppe, additional, Colella, Elisa, additional, Valsecchi, Maria G., additional, Migliorino, Guglielmo M., additional, D'Ambrosio, Roberta, additional, Landonio, Simona, additional, Schiavini, Monica, additional, Spinetti, Angiola, additional, Carriero, Canio, additional, Degasperi, Elisabetta, additional, Cologni, Giuliana, additional, Gatti, Federico, additional, Viganò, Paolo, additional, Hasson, Hamid, additional, Uberti‐Foppa, Caterina, additional, Pasulo, Luisa, additional, Baiguera, Chiara, additional, Rossotti, Roberto, additional, Vinci, Maria, additional, Puoti, Massimo, additional, Giorgini, Alessia, additional, Menzaghi, Barbara, additional, Lombardi, Andrea, additional, Pan, Angelo, additional, Aghemo, Alessio, additional, Grossi, Paolo A., additional, Boldizzoni, Roberto, additional, Colombo, Silvia, additional, Viganò, Mauro, additional, Rumi, Maria G., additional, Del Poggio, Paolo, additional, Valenti, Luca, additional, Giglio, Omar, additional, De Bona, Anna, additional, d'Arminio Monforte, Antonella, additional, Colombo, Alberto, additional, Spinelli, Ombretta, additional, Pigozzi, Marie G., additional, Molteni, Chiara, additional, Bonfanti, Paolo, additional, Terreni, Natalia, additional, Perini, Paolo, additional, Capretti, Andrea, additional, Bella, Daniele, additional, Liani, Cecilia, additional, Polo, Silvia, additional, Aimo, Gianpiero, additional, Pagnucco, Layla, additional, Bhoori, Sherrie, additional, Centenaro, Riccardo, additional, Graffeo, Massimo, additional, Ciaccio, Antonio, additional, Dionigi, Elena, additional, Lazzaroni, Sergio, additional, Carderi, Isabella, additional, Di Marco, Mariella, additional, Rizzardini, Giuliano, additional, Noventa, Franco, additional, Lampertico, Pietro, additional, and Fagiuoli, Stefano, additional

Published
2020
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41. Serial 2-Point Ultrasonography Plus D-Dimer vs Whole-Leg Color-Coded Doppler Ultrasonography for Diagnosing Suspected Symptomatic Deep Vein Thrombosis: A Randomized Controlled Trial

Author

Bernardi, Enrico, Camporese, Giuseppe, Büller, Harry R., Siragusa, Sergio, Imberti, Davide, Berchio, Arrigo, Ghirarduzzi, Angelo, Verlato, Fabio, Anastasio, Raffaela, Prati, Carolina, Piccioli, Andrea, Pesavento, Raffaele, Bova, Carlo, Maltempi, Patrizia, Zanatta, Nello, Cogo, Alberto, Cappelli, Roberto, Bucherini, Eugenio, Cuppini, Stefano, Noventa, Franco, and Prandoni, Paolo

Published
2008

48. Prevalence of liver disease in a population of asymptomatic persons with hepatitis C virus infection

Author

Alberi, Alfredo, Noventa, Franco, Benvegnu, Luisa, Boccato, Silvia, and Gatta, Angelo

Subjects
Hepatitis C -- Physiological aspects, Hepatitis C -- Development and progression, Health
Abstract

Background: The prevalence of significant liver disease in persons with asymptomatic hepatitis C virus (HCV) infection is unclear. Objective: To determine the prevalence and severity of HCV infection in asymptomatic persons. Design: Population-based cross-sectional study. Setting: Northeastern Italy. Patients: 4820 apparently healthy Telecom Italy employees or their relatives who underwent screening for cardiovascular risk factors. Measurements: Initial screening for anti-HCV by enzyme-linked immunosorbent assay followed by HCV RNA testing by polymerase chain reaction and monitoring of alanine aminotransferase levels in viremic persons (92% of viremic persons also had liver biopsies to assess their METAVIR scores). Results: 116 persons (2.4% [95% CI, 1.97% to 2.84%]) were positive for anti-HCV and 85 (1.76% [CI, 1.39% to 2.14%]) were also viremic. The ALT level was persistently normal in 39 (46%) of viremic patients and elevated in 46 (54%). Significant hepatic histologic abnormalities were detected in 19% (CI, 7.21% to 36.4%) of persons with persistently normal ALT levels and in 61% (CI, 45.4% to 74.9%) of viremic persons who had elevated ALT levels (P Conclusions: Hepatitis C is histologically active and progressive in up to 40% of asymptomatic persons with HCV infection. The severity of liver disease correlates with abnormal ALT levels and increases with age.

Published
2002

49. Efficacy of Rivaroxaban for thromboprophylaxis after Knee Arthroscopy (ERIKA)

Author

Camporese, Giuseppe, Bernardi, Enrico, Noventa, Franco, Bosco, Mario, Monteleone, Giuseppe, Santoro, Luca, Bortoluzzi, Cristiano, Freguja, Stefano, Nardin, Michela, Marullo, Matteo, Zanon, Giacomo, Mazzola, Claudio, Damiani, Guido, Maniscalco, Pietro, Imberti, Davide, Lodigiani, Corrado, Becattini, Cecilia, Tonello, Chiara, Agnelli, Giancarlo, Tonello, C., Bosco, M., Monteleone, G., Santoro, L., Santoliquido, A., Di Giorgio, A., Nicolardi, E., Biondi, G., Fieri, C., Dall’Acqua, D., De Matthaeis, A., Giannotta, L., Masciangelo, M., Taccardo, G., De Vitis, R., Militerno, A., Serpieri, S., Cilli, V., Bortoluzzi, C., Freguja, S., Nardin, M., Parisi, R., Marullo, M., Azzaretti, A., Zanon, G., Mazzola, C., Damiani, G., Gori, A., Cassola, P., Zabzuni, D., Lodigiani, C., Volpi, P., Bait, C., Vitali, S., Vedovati, MARIA CRISTINA, Di Micco, P., Dimaro, P., Ghirarduzzi, A., and Veropalumbo, R.

Subjects
Adult, Male, medicine.medical_specialty, Knee Joint, Anterior cruciate ligament reconstruction, medicine.medical_treatment, 030204 cardiovascular system & hematology, Placebo, Asymptomatic, Arthroscopy, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Rivaroxaban, Risk Factors, Settore MED/41 - ANESTESIOLOGIA, medicine, Humans, Bleeding, Prophylaxis, Venous thromboembolism, Hematology, 030212 general & internal medicine, Meniscectomy, Venous Thrombosis, Settore MED/12 - Gastroenterologia, Knee arthroscopy, Anterior Cruciate Ligament Reconstruction, medicine.diagnostic_test, business.industry, Absolute risk reduction, Middle Aged, Surgery, Relative risk, Female, medicine.symptom, business, Factor Xa Inhibitors, medicine.drug
Abstract

SummaryWithout thromboprophylaxis, knee arthroscopy (KA) carries a low to moderate risk of venous thromboembolism. Over 5 million arthroscopies are performed worldwide yearly. It was our study objective to assess the efficacy and safety of rivaroxaban for thromboprophylaxis after therapeutic KA. Patients undergoing KA in nine Italian teaching or community hospitals were allocated to once-daily rivaroxaban (10 mg) or placebo for seven days in a phase II, multicentre, double-blind, placebo-controlled randomised trial. The primary efficacy outcome was a composite of all-cause death, symptomatic thromboembolism and asymptomatic proximal DVT at three months; major bleeding represented the primary safety outcome. All patients underwent whole-leg ultrasonography at day 7(+1), or earlier if symptomatic. A total of 241 patients were randomised (122 rivaroxaban, 119 placebo), and 234 completed the study. The primary efficacy outcome occurred in 1/120 of the rivaroxaban group and in 7/114 of the placebo group (0.8% vs 6.1%, respectively, p=0.03; absolute risk difference, −5.3%, 95% CI, −11.4 to −0.8; crude relative risk 0.14, 95% CI, 0.02 to 0.83; number-needed-to-treat=19). No major bleedings were observed. We found no association between different arthroscopic procedures and thrombotic events. Small sample size, high exclusion rate, and low number of anterior cruciate ligament reconstruction procedures are the main limitations of our study. In conclusion, a seven-day course of 10-mg rivaroxaban may be safely employed for thromboprophylaxis after KA. Whether prophylaxis after KA should be given to all patients, or to selected “high-risk” subjects, remains to be determined. A larger trial to verify our preliminary results is warranted.

Published
2016
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50. Deep-vein thrombosis and the incidence of subsequence symptomatic cancer

Author

Prandoni, Paolo, Lensing, Anthonie W.A., Buller, Harry R., Cogo, Alberto, Prins, Martin H., Cattelan, Anna M., Cuppini, Stefano, Noventa, Franco, and Cate, Jan W. ten

Subjects
Venous thrombosis -- Causes of, Cancer -- Complications
Abstract

There may be an association between deep-vein thrombosis and the development of cancer, especially in patients who have recurrent episodes of unknown cause. Deep-vein thrombosis is the formation of a blood clot in a major vein. Among 250 patients with a first episode of deep-vein thrombosis who were followed over a two-year period, 145 were diagnosed with idiopathic venous thrombosis, or thrombosis of unknown cause, and 105 developed a venous thrombosis secondary to another disease. Eleven patients (7.6%) with idiopathic venous thrombosis developed symptomatic cancer during the follow-up period, compared with two patients (1.9%) with secondary venous thrombosis. Thirty-five patients with idiopathic venous thrombosis had recurring episodes of thrombosis. Six of these patients (17%) later developed cancer. Some patients with recurrent idiopathic venous thrombosis may be suffering from cancer, but have not developed symptoms yet.

Published
1992

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