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A mixture DMSO-allyl bromide has been developed as a reagent for an atom economic one-pot N -allylation and aryl bromination under basic conditions. Utilizing this reagent, N -allylation-bromination of a number of 2°-aryl amines, aryl aminoamides, indoles, and 7-aza indoles has been achieved. The scope of the substrates and limitations, the synthetic utility of the products, and a plausible reaction mechanism have been proposed., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

A facile and diversity-oriented approach has been developed for the synthesis of pyrrole-, pyridine-, or azepine-appended (het)aryl aminoamides via the N -allylation/homoallylation-ring-closing metathesis (RCM) strategy. Microwave condition was efficiently utilized for N -allylation of (het)aryl aminoamides to synthesize di-, tri-, and tetra-allyl/homoallylated RCM substrates in good yields. All of the RCM substrates were successfully converted to respective pyrroles 6a-h , 13a , b , 15a , b , pyridines 11a-d , 13c , and azepines 7a , b via RCM. All of the five-, six-, and seven-membered N -heterocycles were synthesized in shorter reaction times with excellent yields without isomerization products. A one-pot reaction to synthesize compounds 6a and 6b without isolating corresponding RCM substrates was achieved successfully. The synthetic utility of the compound 6b has been demonstrated by synthesizing biaryl derivatives 17a , b under the microwave Suzuki coupling reaction condition., Competing Interests: The authors declare no competing financial interest., (Copyright © 2020 American Chemical Society.)

Marine sponges are a rich source of more than 50% of marine natural compounds that have been isolated from marine organisms. This review article is focused on the importance of biologically active and pharmaceutically important secondary metabolites extracted from one of the important classes of marine sponge Hyrtios sp. This review also deals with reported synthetic routes of some indole alkaloids extracted from the marine sponge Hyrtios sp. A range of bioactivities displayed by indole-based alkaloids is described., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

In the mol-ecule of the title compound, C(20)H(23)NO(3), the bulky methoxy-phenyl substituents at the equatorial 2,6-positions crowd the vicinity of the equatorial amino H atom and prevent it from forming inter-molecular hydrogen bonds. The piperidine ring adopts a distorted chair conformation.