191 results on '"Novaković S"'
Search Results
2. Novel Indole-Pyrazine Alkaloid: Synthesis, Characterization, and Crystal Structure
- Author
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Ghalib, R. M., Mehdi, S. H., Malla, A. M., Alam, M. G., Hashim, R., Novaković, S. B., Kawamura, F., and Alzahrani, H. A. H.
- Published
- 2021
- Full Text
- View/download PDF
3. LP-60: Bisphenol A and its effects on human ovarian granulosa cell line COV434
- Author
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Celar Šturm, D., primary, Škerl, P., additional, Novaković, S., additional, and Virant Klun, I., additional
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- 2023
- Full Text
- View/download PDF
4. Synthesis, Crystal Structure, and Spectral Study of a Novel Indenoimidazole Carboxylic Acid Amide
- Author
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Ghalib, R. M., primary, Mehdi, S. H., additional, Malla, A. M., additional, Alam, M. G., additional, Novaković, S. B., additional, Gupta, A. K., additional, and Alzahrani, H. A. H., additional
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- 2021
- Full Text
- View/download PDF
5. 81 Cytological samples for detection of BRCA 1/2 mutations in patients with high grade serous ovarian cancer
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Skof, E, primary, Novaković, S, additional, Stegel, V, additional, Miceska, S, additional, Krajc, M, additional, Bebar, S, additional, Kloboves-Prevodnik, V, additional, Setrajcic Dragos, V, additional, and Blatnik, A, additional
- Published
- 2021
- Full Text
- View/download PDF
6. 558 Non-BRCA1/2 pathogenic/likely pathogenic variants detected in 2.6% of patients with ovarian, fallopian tube or primary peritoneal cancer
- Author
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Mesaric, VA, primary, Drusany Staric, K, additional, Hotujec, S, additional, Strojnik, K, additional, Blatnik, A, additional, Banjac, M, additional, Skof, E, additional, Stegel, V, additional, Novaković, S, additional, and Krajc, M, additional
- Published
- 2021
- Full Text
- View/download PDF
7. 2337P Feasibility of mutation detection in cytological samples from metastasis in patients with metastatic prostate cancer
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Mencinger, M., Kloboves Prevodnik, V., Novakovic, S., and Seruga, B.
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- 2023
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- View/download PDF
8. Introducing a novel crystal form of pyruvic acid thiosemicarbazone and its sodium salt
- Author
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Belošević Svetlana K., Novaković Slađana B., Rodić Marko V., Leovac Vukadin M., Vojinović-Ješić Ljiljana S., Bogdanović Goran A., and Radanović Mirjana M.
- Subjects
thiosemicarbazone ,crystal structure ,physicochemical properties ,metal complexes ,hydrogen bonding ,Chemistry ,QD1-999 - Abstract
The reaction of thiosemicarbazide and sodium pyruvate has been thoroughly studied and the novel crystal form of pyruvic acid thiosemicarbazone (H2pt) and its sodium salt was obtained. Compounds were characterized by IR spectra, melting points, elemental analysis, conductometric measurements and single-crystal X-ray analysis. A detailed comparative analysis of crystal structures of these compounds is given, as well as comparison with some of the earlier known complexes containing H2pt. The two novel crystal structures exhibit notably different hydrogen bonding patterns, mutually and in comparison with previously reported crystal form of H2pt. All crystal structures are stabilized by extensive network of N–H⋅⋅⋅O, O–H⋅⋅⋅O and N–H⋅⋅⋅S hydrogen bonds. The cyclic hydrogen bonding motif involving the thioureido moieties of the ligand is the only one which repeats in each structure.
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- 2024
- Full Text
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9. Geographical distribution of Slovenian BRCA1/2 families according to family origin: implications for genetic screening
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Krajc, M, Zadnik, V, Novaković, S, Stegel, V, Teugels, E, Bešič, N, Hočevar, M, Vakselj, A, De Grève, J, and Žgajnar, J
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- 2014
- Full Text
- View/download PDF
10. Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
- Author
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Landi, M.T. Bishop, D.T. MacGregor, S. Machiela, M.J. Stratigos, A.J. Ghiorzo, P. Brossard, M. Calista, D. Choi, J. Fargnoli, M.C. Zhang, T. Rodolfo, M. Trower, A.J. Menin, C. Martinez, J. Hadjisavvas, A. Song, L. Stefanaki, I. Scolyer, R. Yang, R. Goldstein, A.M. Potrony, M. Kypreou, K.P. Pastorino, L. Queirolo, P. Pellegrini, C. Cattaneo, L. Zawistowski, M. Gimenez-Xavier, P. Rodriguez, A. Elefanti, L. Manoukian, S. Rivoltini, L. Smith, B.H. Loizidou, M.A. Del Regno, L. Massi, D. Mandala, M. Khosrotehrani, K. Akslen, L.A. Amos, C.I. Andresen, P.A. Avril, M.-F. Azizi, E. Soyer, H.P. Bataille, V. Dalmasso, B. Bowdler, L.M. Burdon, K.P. Chen, W.V. Codd, V. Craig, J.E. Dębniak, T. Falchi, M. Fang, S. Friedman, E. Simi, S. Galan, P. Garcia-Casado, Z. Gillanders, E.M. Gordon, S. Green, A. Gruis, N.A. Hansson, J. Harland, M. Harris, J. Helsing, P. Henders, A. Hočevar, M. Höiom, V. Hunter, D. Ingvar, C. Kumar, R. Lang, J. Lathrop, G.M. Lee, J.E. Li, X. Lubiński, J. Mackie, R.M. Malt, M. Malvehy, J. McAloney, K. Mohamdi, H. Molven, A. Moses, E.K. Neale, R.E. Novaković, S. Nyholt, D.R. Olsson, H. Orr, N. Fritsche, L.G. Puig-Butille, J.A. Qureshi, A.A. Radford-Smith, G.L. Randerson-Moor, J. Requena, C. Rowe, C. Samani, N.J. Sanna, M. Schadendorf, D. Schulze, H.-J. Simms, L.A. Smithers, M. Song, F. Swerdlow, A.J. van der Stoep, N. Kukutsch, N.A. Visconti, A. Wallace, L. Ward, S.V. Wheeler, L. Sturm, R.A. Hutchinson, A. Jones, K. Malasky, M. Vogt, A. Zhou, W. Pooley, K.A. Elder, D.E. Han, J. Hicks, B. Hayward, N.K. Kanetsky, P.A. Brummett, C. Montgomery, G.W. Olsen, C.M. Hayward, C. Dunning, A.M. Martin, N.G. Evangelou, E. Mann, G.J. Long, G. Pharoah, P.D.P. Easton, D.F. Barrett, J.H. Cust, A.E. Abecasis, G. Duffy, D.L. Whiteman, D.C. Gogas, H. De Nicolo, A. Tucker, M.A. Newton-Bishop, J.A. Peris, K. Chanock, S.J. Demenais, F. Brown, K.M. Puig, S. Nagore, E. Shi, J. Iles, M.M. Law, M.H. GenoMEL Consortium Q-MEGA QTWIN Investigators ATHENS Melanoma Study Group 23andMe The SDH Study Group IBD Investigators Essen-Heidelberg Investigators AMFS Investigators MelaNostrum Consortium
- Abstract
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified 54 significant (P < 5 × 10−8) loci with 68 independent single nucleotide polymorphisms. Analysis of risk estimates across geographical regions and host factors suggests the acral melanoma subtype is uniquely unrelated to pigmentation. Combining this meta-analysis with GWAS of nevus count and hair color, and transcriptome association approaches, uncovered 31 potential secondary loci for a total of 85 cutaneous melanoma susceptibility loci. These findings provide insights into cutaneous melanoma genetic architecture, reinforcing the importance of nevogenesis, pigmentation and telomere maintenance, together with identifying potential new pathways for cutaneous melanoma pathogenesis. © 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
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- 2020
11. Overlapping genetic architecture between Parkinson disease and melanoma
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Dube, Umber, Ibanez, Laura, Budde, John P., Benitez, Bruno A., Davis, Albert A., Harari, Oscar, Iles, M. M., Law, Matthew H., Brown, Kevin M., Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Bishop, D. T., Lee, J. E., Brossard, M., Martin, N. G., Moses, E. K., Song, F., Barrett, J. H., Kumar, R., Easton, D. F., Pharoah, P. D., Swerdlow, A. J., Kypreou, K. P., Taylor, J. C., Harland, M., Randerson-Moor, J., Akslen, L. A., Andresen, P. A., Avril, M. F., Azizi, E., Scarrà, G. B., Brown, K. M., Debniak, T., Duffy, D. L., Elder, D. E., Fang, S., Friedman, E., Galan, P., Ghiorzo, P., Gillanders, E. M., Goldstein, A. M., Gruis, N. A., Hansson, J., Helsing, P., Hočevar, M., Höiom, V., Ingvar, C., Kanetsky, P. A., Chen, W. V., Landi, M. T., Lang, J., Lathrop, G. M., Lubiński, J., Mackie, R. M., Mann, G. J., Molven, A., Montgomery, G. W., Novaković, S., Olsson, H., Puig, S., Puig-Butille, J. A., Wu, W., Qureshi, A. A., Radford-Smith, G. L., van der Stoep, N., van Doorn, R., Whiteman, D. C., Craig, J. E., Schadendorf, E., Simms, L. A., Burdon, K. P., Nyholt, D. R., Pooley, K. A., Orr, N., Stratigos, A. J., Cust, A. E., Ward, S. V., Hayward, N. K., Han, J., Schulze, H. J., Dunning, A. M., Bishop, J. A., Demenais, F., Amos, C. I., MacGregor, S., Cruchaga, Carlos, other, and, Dube, Umber, Ibanez, Laura, Budde, John P., Benitez, Bruno A., Davis, Albert A., Harari, Oscar, Iles, M. M., Law, Matthew H., Brown, Kevin M., Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre, Furlotte, Nicholas A., Hinds, David A., Huber, Karen E., Kleinman, Aaron, Litterman, Nadia K., McCreight, Jennifer C., McIntyre, Matthew H., Mountain, Joanna L., Noblin, Elizabeth S., Northover, Carrie A.M., Pitts, Steven J., Sathirapongsasuti, J. Fah, Sazonova, Olga V., Shelton, Janie F., Shringarpure, Suyash, Tian, Chao, Tung, Joyce Y., Vacic, Vladimir, Wilson, Catherine H., Bishop, D. T., Lee, J. E., Brossard, M., Martin, N. G., Moses, E. K., Song, F., Barrett, J. H., Kumar, R., Easton, D. F., Pharoah, P. D., Swerdlow, A. J., Kypreou, K. P., Taylor, J. C., Harland, M., Randerson-Moor, J., Akslen, L. A., Andresen, P. A., Avril, M. F., Azizi, E., Scarrà, G. B., Brown, K. M., Debniak, T., Duffy, D. L., Elder, D. E., Fang, S., Friedman, E., Galan, P., Ghiorzo, P., Gillanders, E. M., Goldstein, A. M., Gruis, N. A., Hansson, J., Helsing, P., Hočevar, M., Höiom, V., Ingvar, C., Kanetsky, P. A., Chen, W. V., Landi, M. T., Lang, J., Lathrop, G. M., Lubiński, J., Mackie, R. M., Mann, G. J., Molven, A., Montgomery, G. W., Novaković, S., Olsson, H., Puig, S., Puig-Butille, J. A., Wu, W., Qureshi, A. A., Radford-Smith, G. L., van der Stoep, N., van Doorn, R., Whiteman, D. C., Craig, J. E., Schadendorf, E., Simms, L. A., Burdon, K. P., Nyholt, D. R., Pooley, K. A., Orr, N., Stratigos, A. J., Cust, A. E., Ward, S. V., Hayward, N. K., Han, J., Schulze, H. J., Dunning, A. M., Bishop, J. A., Demenais, F., Amos, C. I., MacGregor, S., Cruchaga, Carlos, and other, and
- Abstract
Epidemiologic studies have reported inconsistent results regarding an association between Parkinson disease (PD) and cutaneous melanoma (melanoma). Identifying shared genetic architecture between these diseases can support epidemiologic findings and identify common risk genes and biological pathways. Here, we apply polygenic, linkage disequilibrium-informed methods to the largest available case–control, genome-wide association study summary statistic data for melanoma and PD. We identify positive and significant genetic correlation (correlation: 0.17, 95% CI 0.10–0.24; P = 4.09 × 10−06) between melanoma and PD. We further demonstrate melanoma and PD-inferred gene expression to overlap across tissues (correlation: 0.14, 95% CI 0.06 to 0.22; P = 7.87 × 10−04) and highlight seven genes including PIEZO1, TRAPPC2L, and SOX6 as potential mediators of the genetic correlation between melanoma and PD. These findings demonstrate specific, shared genetic architecture between PD and melanoma that manifests at the level of gene expression.
- Published
- 2020
12. Correlation of t(14;18) translocation breakpoint site with clinical characteristics in follicular lymphoma
- Author
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Panjan Matej, Boltezar Lucka, Novakovic Srdjan, Kokovic Ira, and Jezersek Novakovic Barbara
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follicular lymphoma ,t(14 ,18) translocation ,breakpoint region ,clinical characteristics ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
t(14;18)(q32;q21) translocation is an important genetic feature of follicular lymphoma resulting in antiapoptotic B-cell lymphoma 2 (BCL2) protein overexpression. On chromosome 18 breakpoint-site variation is high but does not affect BCL2. Breakpoint most commonly occurs at major breakpoint region (MBR) but may happen at minor cluster region (mcr) and between MBR and mcr at 3′MBR and 5′mcr. The aim of this study was to analyze the correlation of t(14;18)(q32;q21) breakpoint site with clinical characteristics in follicular lymphoma.
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- 2023
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13. Association between PIK3CA activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy
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Ribnikar Domen, Horvat Valentina Jeric, Ratosa Ivica, Veitch Zachary W, Grcar Kuzmanov Biljana, Novakovic Srdjan, Langerholc Erik, Amir Eitan, and Seruga Bostjan
- Subjects
invasive lobular carcinoma ,pik3ca mutation ,endocrine therapy ,genomics of invasive lobular carcinoma ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
The aim of the study was to evaluate the independent prognostic role of PIK3CA activating mutations and an association between PIK3CA activating mutations and efficacy of adjuvant endocrine therapy (ET) in patients with operable invasive lobular carcinoma (ILC).
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- 2023
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14. Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
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Duffy, David L, Zhu, Gu, Xin, Li, Sanna, Marianna, Iles, Mark M, Jacobs, Leonie C, Evans, David M, Yazar, Seyhan, Beesley, Jonathan, Law, Matthew H, Kraft, Peter, Visconti, Alessia, Taylor, John C, Lui, Fan, Wright, Margaret J, Henders, Anjali K, Bowdler, Lisa, Glass, Dan, Ikram, Arfan M, Uitterlinden, André G, Madden, Pamela A, Heath, Andrew C, Nelson, Elliot C, Green, Adele C, Chanock, Stephen, Barrett, Jennifer H, Brown, Matthew A, Hayward, Nicholas K, Macgregor, Stuart, Sturm, Richard A, Hewitt, Alex W, Kayser, Manfred, Hunter, David J, Newton Bishop, Julia A, Spector, Timothy D, Montgomery, Grant W, Mackey, David A, Smith, George Davey, Nijsten, Tamar E, Bishop, D Timothy, Bataille, Veronique, Falchi, Mario, Han, Jiali, Martin, Nicholas, G, Lee, Je, Brossard, M, Moses, Ek, Song, F, Kumar, R, Easton, Df, Pharoah, Pdp, Swerdlow, Aj, Kypreou, Kp, Harland, M, Randerson-Moor, J, Akslen, La, Andresen, Pa, Avril, Mf, Azizi, E, Scarrà, Gb, Brown, Km, Dębniak, T, Elder, De, Fang, S, Friedman, E, Galan, P, Ghiorzo, P, Gillanders, Em, Goldstein, Am, Gruis, Na, Hansson, J, Helsing, P, Hočevar, M, Höiom, V, Ingvar, C, Kanetsky, Pa, Chen, Wv, Landi, Mt, Lang, J, Lathrop, Gm, Lubiński, J, Mackie, Rm, Mann, Gj, Molven, A, Novaković, S, Olsson, H, Puig, S, Puig-Butille, Ja, Radford-Smith, Gl, van der Stoep, N, van Doorn, R, Whiteman, Dc, Craig, Je, Schadendorf, D, Simms, La, Burdon, Kp, Nyholt, Dr, Pooley, Ka, Orr, N, Stratigos, Aj, Cust, Ae, Ward, Sv, Schulze, Hj, Dunning, Am, Demenais, F, Amos, Ci., Apollo - University of Cambridge Repository, Dermatology, Genetic Identification, Epidemiology, Internal Medicine, and Consortium, Melanoma Gwas
- Subjects
0301 basic medicine ,Skin Neoplasms ,Medizin ,General Physics and Astronomy ,Genome-wide association study ,Receptors, G-Protein-Coupled ,0302 clinical medicine ,Guanine Nucleotide Exchange Factors ,lcsh:Science ,skin and connective tissue diseases ,Melanoma ,Telomerase ,Genetics ,0303 health sciences ,Nevus, Pigmented ,Stem Cell Factor ,Multidisciplinary ,Microfilament Proteins ,Nuclear Proteins ,RNA-Binding Proteins ,Genetic Pleiotropy ,Microphthalmia-associated transcription factor ,3. Good health ,030220 oncology & carcinogenesis ,Cytochrome P-450 CYP1B1 ,Interferon Regulatory Factors ,Medical genetics ,PPARGC1B ,Dock8 ,medicine.medical_specialty ,Science ,Telomere-Binding Proteins ,Single-nucleotide polymorphism ,Nerve Tissue Proteins ,Biology ,Polymorphism, Single Nucleotide ,General Biochemistry, Genetics and Molecular Biology ,Histone Deacetylases ,White People ,Group VI Phospholipases A2 ,03 medical and health sciences ,Genetic predisposition ,Pigmented Nevus ,medicine ,Nevus ,Humans ,Genetic Predisposition to Disease ,neoplasms ,030304 developmental biology ,General Chemistry ,medicine.disease ,Repressor Proteins ,MicroRNAs ,030104 developmental biology ,Cutaneous melanoma ,RNA ,lcsh:Q ,Carrier Proteins ,IRF4 ,Genome-Wide Association Study - Abstract
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, United Kingdom, and United States, comprising a total of 52,506 phenotyped individuals. We confirm known loci including MTAP, PLA2G6, and IRF4, and detect novel SNPs at a genome-wide level of significance in KITLG, DOCK8, and a broad region of 9q32. In a bivariate analysis combining the nevus results with those from a recent melanoma GWAS meta-analysis (12,874 cases, 23,203 controls), SNPs near GPRC5A, CYP1B1, PPARGC1B, HDAC4, FAM208B and SYNE2 reached global significance, and other loci, including MIR146A and OBFC1, reached a suggestive level of significance. Overall, we conclude that most nevus genes affect melanoma risk (KITLG an exception), while many melanoma risk loci do not alter nevus count. For example, variants in TERC and OBFC1 affect both traits, but other telomere length maintenance genes seem to affect melanoma risk only. Our findings implicate multiple pathways in nevogenesis via genes we can show to be expressed under control of the MITF melanocytic cell lineage regulator.
- Published
- 2018
15. Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes
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Zhang, Tongwu, Choi, Jiyeon, Kovacs, Michael A., Shi, Jianxin, Mai, Xu, Goldstein, Alisa M., Trower, Adam J., Bishop, D. Timothy, Iles, Mark M., Duffy, David L., Macgregor, Stuart, Amundadottir, Laufey T., Law, Matthew H., Loftus, Stacie K., Pavan, William J., Brown, Kevin M., Lee, Je, Brossard, M, Martin, Ng, Moses, Ek, Song, F, Barrett, Jh, Kumar, R, Easton, Df, Pharoah, Pdp, Swerdlow, Aj, Kypreou, Kp, Taylor, Jc, Harland, M, Randerson-Moor, J, Akslen, La, Andresen, Pa, Avril, Mf, Azizi, E, Bianchi Scarrà, G, Dȩbniak, T, Duffy, Dl, Elder, De, Fang, S, Friedman, E, Galan, P, Ghiorzo, P, Gillanders, Em, Goldstein, Am, Gruis, Na, Hansson, J, Helsing, P, Hočevar, M, Höiom, V, Ingvar, C, Kanetsky, Pa, Chen, Wv, Landi, Mt, Lang, J, Lathrop, Gm, Lubiński, J, Mackie, Rm, Mann, Gj, Molven, A, Montgomery, Gw, Novaković, S, Olsson, H, Puig, S, Puig-Butille, Ja, Wu, W, Qureshi, Aa, Radford-Smith, Gl, van der Stoep, N, van Doorn, R, Whiteman, Dc, Craig, Je, Schadendorf, D, Simms, La, Burdon, Kp, Nyholt, Dr, Pooley, Ka, Orr, N, Stratigos, Aj, Cust, Ae, Ward, Sv, Hayward, Nk, Han, J, Schulze, Hj, Dunning, Am, Bishop, Jan, Demenais, F, Amos, Ci, Macgregor, S, Iles, Mm, Barnabas, Bb, Bouffard, Gg, Brooks, Sy, Coleman, H, Dekhtyar, L, Guan, X, Ho, Sl, Legaspi, R, Maduro, Ql, Masiello, Ca, Mcdowell, Jc, Montemayor, C, Mullikin, Jc, Park, M, Riebow, Nl, Schandler, K, Schmidt, B, Sison, C, Smith, R, Stantripop, S, Thomas, Jw, Thomas, Pj, Vemulapalli, M, and Young, Ac.
- Subjects
0301 basic medicine ,Hemeproteins ,Linkage disequilibrium ,Quantitative Trait Loci ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Quantitative trait locus ,Melanocyte ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,03 medical and health sciences ,Heme-Binding Proteins ,0302 clinical medicine ,Genetics ,medicine ,Basic Helix-Loop-Helix Transcription Factors ,Humans ,Genetic Predisposition to Disease ,Melanoma ,Genetics (clinical) ,Cells, Cultured ,Genetic association ,Research ,medicine.disease ,Repressor Proteins ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Expression quantitative trait loci ,Interferon Regulatory Factors ,Melanocytes ,Carrier Proteins - Abstract
Most expression quantitative trait locus (eQTL) studies to date have been performed in heterogeneous tissues as opposed to specific cell types. To better understand the cell-type–specific regulatory landscape of human melanocytes, which give rise to melanoma but account for cis-eQTL SNPs prior to linkage disequilibrium (LD) pruning and 4997 eGenes (FDR < 0.05). Melanocyte eQTLs differed considerably from those identified in the 44 GTEx tissue types, including skin. Over a third of melanocyte eGenes, including key genes in melanin synthesis pathways, were unique to melanocytes compared to those of GTEx skin tissues or TCGA melanomas. The melanocyte data set also identified trans-eQTLs, including those connecting a pigmentation-associated functional SNP with four genes, likely through cis-regulation of IRF4. Melanocyte eQTLs are enriched in cis-regulatory signatures found in melanocytes as well as in melanoma-associated variants identified through genome-wide association studies. Melanocyte eQTLs also colocalized with melanoma GWAS variants in five known loci. Finally, a transcriptome-wide association study using melanocyte eQTLs uncovered four novel susceptibility loci, where imputed expression levels of five genes (ZFP90, HEBP1, MSC, CBWD1, and RP11-383H13.1) were associated with melanoma at genome-wide significant P-values. Our data highlight the utility of lineage-specific eQTL resources for annotating GWAS findings, and present a robust database for genomic research of melanoma risk and melanocyte biology.
- Published
- 2018
16. The feasibility of pulsed light processing in the meat industry
- Author
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Tomasevic, I, primary, Djekic, I, additional, Novaković, S, additional, Barba, F, additional, and Lorenzo, J M, additional
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- 2019
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17. CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review
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Gasljevic Gorana, Boltezar Lucka, Novakovic Srdjan, Setrajcic-Dragos Vita, Jezersek-Novakovic Barbara, and Kloboves-Prevodnik Veronika
- Subjects
diffuse large b-cell lymphoma not otherwise specified ,cd56 ,immunohistochemistry ,genetic profiling ,prognosis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. The expression of CD56 in DLBCL is highly unusual. Little is known about its incidence and clinical importance. So far, no genetic profiling was performed in CD56 positive DLBCL.
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- 2023
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18. Searching for new TNF-α analogs having potential application in cancer therapy
- Author
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Menart, V., Kus, B., Novaković, S., Serša, G., Gaberc-Porekar, V., Harb, V., Miličić, S., and Štalc, A.
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- 1996
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19. A comparison between Warner-Bratzler shear force measurement and texture profile analysis of meat and meat products: a review
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Novaković, S, primary and Tomašević, I, additional
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- 2017
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20. Job Satisfaction of employees in the municipal police (militia) of the Republic of Serbia
- Author
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Manić Aleksandar, Manić Saška, Novaković Srđan, and Karabašević Darjan
- Subjects
communal police ,job satisfaction ,motivation ,Commerce ,HF1-6182 ,Finance ,HG1-9999 - Abstract
The research was designed as a cross-sectional study in two time periods (2014 and 2019) on a selected sample in 12 cities of the Republic of Serbia. It aims to find out about the level of job satisfaction of employees in the municipal police (Official Gazette of the RS, No. 51/2009) - militia (Official Gazette of the RS, No. 49/2019). In order to obtain valid results from the respondents, the measurement of the degree of satisfaction was carried out by means of an anonymous standardized questionnaire for measuring job satisfaction - Job Satisfaction Survey (JSS). The collected data were processed by Descriptive statistical analysis (Macura, Kovacevic, 2018), determined is medium value, relationships and connections with categorical by division on the subscales and total scales For pleasure by work: dissatisfied, ambivalent and satisfied. T test of independent samples performed is a comparison of mean values on the job satisfaction scale and all its subscales. Standard multiple regression analysis of certain is mutual and influence and statistics the significance of the set variables on Employee Job Satisfaction. The results showed a statistically significant influence between the subscales on the job satisfaction scale, where the greatest influence on employee dissatisfaction in 2014 was the salary, promotion, benefits, rewards and the very nature of the job. The greatest influence on employee ambivalence was satisfaction with work procedures and satisfaction with communications in 2014, while in 2019 the greatest influence on employee ambivalence was satisfaction with co-workers, rewards, the very nature of work and communication.
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- 2022
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21. Pallet truck selection with MEREC and WISP-S methods
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Ulutaş Alptekin, Stanujkić Dragiša, Karabašević Darjan, Popović Gabrijela, and Novaković Srđan
- Subjects
wisp-s ,merec ,pallet truck ,logistics ,Production management. Operations management ,TS155-194 ,Personnel management. Employment management ,HF5549-5549.5 - Abstract
Background: The article presents an MCDM model based on the MEREC and WISP-S methods for pallet truck selection. Purpose: The main purpose of the study was to apply a new MCDM model for pallet truck selection in the textile workshop. Study design/methodology/approach: This article presents a simplified adoption of the Simple Weighted Sum Product (WISP) method, the Simplified WISP (WISP-S) method. The proposed method has fewer computation steps than the regular WISP method. In addition, this study proposes a new hybrid MCDM model in the literature by combining the MEREC method and the WISP-S method. Finding/conclusions: The obtained results can be achieved in a shorter time compared to regular WISP. The application of the new method is considered in this study. In order to check whether the WISP-S method achieves accurate results, the results of the WISP-S method and the results of the ROV and WASPAS methods were compared. As a result of the comparison of the results of the methods, it was observed that the WISP-S method achieved accurate results. Limitations/future research: As a direction for future research, other MCDM models can be applied for solving the same problem. When it comes to the limitations of the proposed model, it can be mentioned that the MCDM model is based on the use of crisp numbers.
- Published
- 2022
- Full Text
- View/download PDF
22. Synthesis and structural characterization of Cd(II) complexes with 2-acetylpyridine-aminoguanidine - a novel coordination mode
- Author
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Radanović Mirjana M., Novaković Slađana B., Rodić Marko V., Vojinović-Ješić Ljiljana S., Janiak Christoph, and Leovac Vukadin M.
- Subjects
guanylhydrazone ,schiff base ,crystal structure ,physicochemical properties ,metal complexes ,Chemistry ,QD1-999 - Abstract
The structures of the first two complexes with bidentate coordination of aminoguanidine Schiff base, i.e., 2-acetylpyridine-aminoguanidine (L), are reported. The complex of the formula [Cd2Cl6(HL)2] (1) was obtained in the reaction of warm aqueous solutions of chloride salts of Cd(II), Zn(II) and the ligand, while the reaction of cadmium bromide and the ligand in the presence of deprotonating agent as well as ammonium thiocyanate resulted in the formation of the complex in which Schiff base has both the role of the ligand and the counterion, viz., [HL][Cd(HL)(NCS)2XY]·H2O (2), where X is Cl- or Br-, and Y Br- or SCN-. The complexes were characterized by IR spectroscopy, elemental analysis, conductometric measurements and single crystal X-ray diffraction. The unusual bidentate coordination of the Schiff base lead to significant changes in the geometry of this molecule (from almost planar in free form and as a tridentate ligand to twisted as a bidentate ligand). Besides, in complex 1 relatively rare bridging coordination of Cl- in octahedral Cd(II) is found, while the crystal structure of complex 2 exhibits substitutional disorder, and contains four different anions: [Cd(HL)(NCS)2Br(SCN)]- (ca. 61 %), [Cd(HL)(NCS)2Cl(SCN)]- (ca. 35 %), [Cd(HL)(NCS)2Br2]- (ca. 3 %) and [Cd(HL)(NCS)2ClBr]- (ca. 1 %).
- Published
- 2022
- Full Text
- View/download PDF
23. Analysis of the efficiency of work of communal police when providing assistance: Case report of the City of Zajecar
- Author
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Manić Aleksandar, Karabašević Darjan, and Novaković Srđan
- Subjects
communal police ,assistance ,service ,materijal efficiency ,immaterial efficiency ,Commerce ,HF1-6182 ,Finance ,HG1-9999 - Abstract
The task of the communal police is primarily reflected in the provision of assistance and services that have their own specifics. When it comes to the communal police in the Republic of Serbia, in that case the duties are reflected in the performance of supervision and control in accordance with the legal authorizations of the city regulations. Accordingly, the communal police, by performing tasks within their jurisdiction, ensures the performance of tasks within the jurisdiction of the City of Zajecar, in the areas of communal activities, environmental protection, people and goods, protection and maintenance of order in the use of land, space, local roads, streets and other public facilities, as well as the unhindered performance of certain tasks within the jurisdiction of the city, and so forth. Having in mind the specifics of the communal police, the aim of the research is to show the efficiency of the work of the Communal Police when providing assistance (2014-2019) through a systematic approach to the processing of data from archival materials, on the example of the service provided to the city authorities, which refers to providing assistance to PC Parking Service Zajecar.
- Published
- 2022
- Full Text
- View/download PDF
24. Clustering of Na+ channels and node of Ranvier formation in remyelinating axons
- Author
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AG Koszowski, Dugandzija-Novaković S, Simon R. Levinson, and Peter Shrager
- Subjects
Immunocytochemistry ,Sodium Channels ,Mitomycins ,Schwann cell proliferation ,Myelin ,Paranodal junction ,Ranvier's Nodes ,medicine ,Animals ,Tissue Distribution ,Remyelination ,Myelin Sheath ,Node of Ranvier ,Chemistry ,General Neuroscience ,Articles ,Immunohistochemistry ,Axons ,Rats ,Cell biology ,medicine.anatomical_structure ,nervous system ,Rats, Inbred Lew ,Female ,Schwann Cells ,Neuroscience ,Cell Division - Abstract
Polyclonal antibodies were raised against a well conserved region of the vertebrate Na+ channel and were affinity purified for use in immunocytochemistry. Focal demyelination of rat sciatic axons was initiated by an intraneural injection of lysolecithin and Na+ channel clustering was followed at several stages of myelin removal and repair. At 1 week post-injection axons contained long, fully demyelinated regions. Na+ channel clusters appeared only at heminodes forming the borders of these zones, and at widely spaced isolated sites that may represent former nodes of Ranvier. Over the next few days proliferating Schwann cells adhered to axons and began to extend processes. Clusters of Na+ channels appeared at the edges of these structures. As the Schwann cells elongated, the clusters seemed to move with them, since they remained at edges and the distance between aggregates increased. Clusters associated with different Schwann cells ultimately approached each other and appeared to fuse. Na+ channels then coalesced further at these sites, forming new nodes of Ranvier in regions that previously were internodal. If Schwann cell proliferation were blocked by mitomycin, no new clusters of Na+ channels appeared within internodes. Under these conditions, heminodal clusters remained visible at 1 week postinjection, but by 2 weeks they were no longer detectable, suggesting that proliferating Schwann cells are required for their maintenance. Clusters at normal nodes of Ranvier remained. It is concluded that Na+ channel aggregation and mobility in demyelinated nerve fibers is controlled by adhering Schwann cells, resulting in the formation of stable new nodes of Ranvier during remyelination.
- Published
- 1995
25. Survival, development, and electrical activity of central nervous system myelinated axons exposed to tumor necrosis factor in vitro
- Author
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Peter Shrager and Dugandzija-Novaković S
- Subjects
Necrosis ,Tumor Necrosis Factor-alpha ,Graft Survival ,Central nervous system ,Action Potentials ,Alpha (ethology) ,In Vitro Techniques ,Biology ,Molecular biology ,Axons ,Oligodendrocyte ,Nerve conduction velocity ,Mice ,Microscopy, Electron ,Cellular and Molecular Neuroscience ,Myelin ,medicine.anatomical_structure ,Spinal Cord ,Immunology ,medicine ,Animals ,Tumor necrosis factor alpha ,medicine.symptom ,Receptor ,Demyelinating Diseases - Abstract
Spinal cord explants from CD-1 mouse embryos were cultured in Maximow slide assemblies to promote myelin development. At about 20 days in vitro, recombinant human or mouse tumor necrosis factor alpha (TNF alpha) was added. Observed 3-8 days later, myelin was largely intact. The myelin blistering and oligodendrocyte damage seen in other strains were generally absent. Axonal conduction was measured optically through the use of a voltage-sensitive dye. Action potential shape, conduction velocity, and refractory period were all unchanged by exposure to TNF alpha. Two series of explants were grown with TNF alpha present continuously throughout the culture period. Observed with light and electron microscopy, myelin developed in at least 50% of the explants treated with recombinant mouse TNF alpha and 80% of those exposed to recombinant human TNF alpha. Optically recorded action potentials were of normal shape and refractory period. Conduction velocities were slightly lower than controls. CD-1 mouse central nervous system contains TNF alpha receptors and yet was resistant to myelin damage. The apparent strain specificity of TNF alpha disruption of myelin may result from more indirect modes of action, including interaction with other cytokines produced by glial cells. Survival of axonal conduction suggests that Na+ channel function remains intact following TNF alpha exposure.
- Published
- 1995
26. Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk
- Author
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Orr, N., Lemnrau, A., Cooke, R., Fletcher, O., Tomczyk, K., Jones, M., Johnson, N., Lord, C. J., Mitsopoulos, C, Zvelebil, M., McDade, S. S., Buck, G., Blancher, C., Trainer, A. H., James, P. A., Bojesen, S. E., Bokm, S., Nevanlinna, H., Mattson, J., Friedman, E, Laitman, Y., Palli, D., Masala, G., Zanna, I., Ottini, L., Giannini, G., Hollestelle, A., Van Den Ouwel, A. M. W., Novaković, S., Krajc, M., Gago Dominguez, Manuela, Castelao Fernández, José Esteban, Olsson, H., Hedenfalk, I., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Bishop, D. T., Neuhausen, S. L., Steele, L., Houlston, R. S., Garcia-Closas, M., Ashworth, A., and Swerdlow, A. J.
- Subjects
Chromosomes, Human, Pair 14 ,DNA-Binding Proteins ,Male ,Neoplasias de la Mama Masculina ,Risk Factors ,European Continental Ancestry Group ,Proteínas de Unión al ADN ,Humans ,Genetic Predisposition to Disease ,Polymorphism, Single Nucleotide ,Breast Neoplasms, Male ,Genome-Wide Association Study ,Estudio de Asociación del Genoma Completo - Abstract
We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10-13; odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10-15; OR = 1.50). Instituto de Salud Carlos III/Programa Grupos Emergentes
- Published
- 2012
27. The effect on melanoma risk of genes previously associated with telomere length.
- Author
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Iles, MM, Bishop, DT, Taylor, JC, Hayward, NK, Brossard, M, Cust, AE, Dunning, AM, Lee, JE, Moses, EK, Akslen, LA, AMFS Investigators, Andresen, PA, Avril, M-F, Azizi, E, Scarrà, GB, Brown, KM, Dębniak, T, Elder, DE, Friedman, E, Ghiorzo, P, Gillanders, EM, Goldstein, AM, Gruis, NA, Hansson, J, Harland, M, Helsing, P, Hočevar, M, Höiom, V, IBD investigators, Ingvar, C, Kanetsky, PA, Landi, MT, Lang, J, Lathrop, GM, Lubiński, J, Mackie, RM, Martin, NG, Molven, A, Montgomery, GW, Novaković, S, Olsson, H, Puig, S, Puig-Butille, JA, QMEGA and QTWIN Investigators, Radford-Smith, GL, Randerson-Moor, J, SDH Study Group, van der Stoep, N, van Doorn, R, Whiteman, DC, MacGregor, S, Pooley, KA, Ward, SV, Mann, GJ, Amos, CI, Pharoah, PDP, Demenais, F, Law, MH, Newton Bishop, JA, Barrett, JH, GenoMEL Consortium, Iles, MM, Bishop, DT, Taylor, JC, Hayward, NK, Brossard, M, Cust, AE, Dunning, AM, Lee, JE, Moses, EK, Akslen, LA, AMFS Investigators, Andresen, PA, Avril, M-F, Azizi, E, Scarrà, GB, Brown, KM, Dębniak, T, Elder, DE, Friedman, E, Ghiorzo, P, Gillanders, EM, Goldstein, AM, Gruis, NA, Hansson, J, Harland, M, Helsing, P, Hočevar, M, Höiom, V, IBD investigators, Ingvar, C, Kanetsky, PA, Landi, MT, Lang, J, Lathrop, GM, Lubiński, J, Mackie, RM, Martin, NG, Molven, A, Montgomery, GW, Novaković, S, Olsson, H, Puig, S, Puig-Butille, JA, QMEGA and QTWIN Investigators, Radford-Smith, GL, Randerson-Moor, J, SDH Study Group, van der Stoep, N, van Doorn, R, Whiteman, DC, MacGregor, S, Pooley, KA, Ward, SV, Mann, GJ, Amos, CI, Pharoah, PDP, Demenais, F, Law, MH, Newton Bishop, JA, Barrett, JH, and GenoMEL Consortium
- Abstract
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
- Published
- 2014
28. A variant in FTO shows association with melanoma risk not due to BMI
- Author
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Iles, Mm, Law, Mh, Stacey, Sn, Han, J, Fang, S, Pfeiffer, R, Harland, M, Macgregor, S, Taylor, Jc, Aben, Kk, Akslen, La, Avril, M, Azizi, E, Bakker, B, Benediktsdottir, Kr, Bergman, W, Scarrà, Gb, Brown, Km, Calista, D, Chaudru, V, Fargnoli, Mc, Cust, Ae, Demenais, F, De Waal, Ac, Dębniak, T, Elder, De, Friedman, E, Galan, P, Ghiorzo, P, Gillanders, Em, Goldstein, Am, Gruis, Na, Hansson, J, Helsing, P, Hočevar, M, Höiom, V, Hopper, Jl, Ingvar, C, Janssen, M, Jenkins, Ma, Kanetsky, Pa, Kiemeney, La, Lang, J, Lathrop, Gm, Leachman, S, Lee, Je, Lubiński, J, Mackie, Rm, Mann, Gj, Martin, Ng, Mayordomo, Ji, Molven, A, Mulder, S, Nagore, E, Novaković, S, Okamoto, I, Olafsson, Jh, Olsson, H, Pehamberger, H, Peris, Ketty, Grasa, Mp, Planelles, D, Puig, S, Puig Butille, Ja, Randerson Moor, J, Requena, C, Rivoltini, L, Rodolfo, M, Santinami, M, Sigurgeirsson, B, Snowden, H, Song, F, Sulem, P, Thorisdottir, K, Tuominen, R, Van Belle, P, Van Der Stoep, N, Van Rossum, Mm, Wei, Q, Wendt, J, Zelenika, D, Zhang, M, Landi, Mt, Thorleifsson, G, Bishop, Dt, Amos, Ci, Hayward, Nk, Stefansson, K, Bishop, Jan, Barrett, Jh, Peris, Ketty (ORCID:0000-0002-5237-0463), Iles, Mm, Law, Mh, Stacey, Sn, Han, J, Fang, S, Pfeiffer, R, Harland, M, Macgregor, S, Taylor, Jc, Aben, Kk, Akslen, La, Avril, M, Azizi, E, Bakker, B, Benediktsdottir, Kr, Bergman, W, Scarrà, Gb, Brown, Km, Calista, D, Chaudru, V, Fargnoli, Mc, Cust, Ae, Demenais, F, De Waal, Ac, Dębniak, T, Elder, De, Friedman, E, Galan, P, Ghiorzo, P, Gillanders, Em, Goldstein, Am, Gruis, Na, Hansson, J, Helsing, P, Hočevar, M, Höiom, V, Hopper, Jl, Ingvar, C, Janssen, M, Jenkins, Ma, Kanetsky, Pa, Kiemeney, La, Lang, J, Lathrop, Gm, Leachman, S, Lee, Je, Lubiński, J, Mackie, Rm, Mann, Gj, Martin, Ng, Mayordomo, Ji, Molven, A, Mulder, S, Nagore, E, Novaković, S, Okamoto, I, Olafsson, Jh, Olsson, H, Pehamberger, H, Peris, Ketty, Grasa, Mp, Planelles, D, Puig, S, Puig Butille, Ja, Randerson Moor, J, Requena, C, Rivoltini, L, Rodolfo, M, Santinami, M, Sigurgeirsson, B, Snowden, H, Song, F, Sulem, P, Thorisdottir, K, Tuominen, R, Van Belle, P, Van Der Stoep, N, Van Rossum, Mm, Wei, Q, Wendt, J, Zelenika, D, Zhang, M, Landi, Mt, Thorleifsson, G, Bishop, Dt, Amos, Ci, Hayward, Nk, Stefansson, K, Bishop, Jan, Barrett, Jh, and Peris, Ketty (ORCID:0000-0002-5237-0463)
- Abstract
We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 × 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanoma-susceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.
- Published
- 2013
29. The prevalence of occult ovarian cancer in the series of 155 consequently operated high risk asymptomatic patients – Slovenian population based study
- Author
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Gornjec Andreja, Merlo Sebastijan, Novakovic Srdjan, Stegel Vida, Gazic Barbara, Perhavec Andraz, Blatnik Ana, and Krajc Mateja
- Subjects
risk-reducing salpingo-oophorectomy (rrso) ,occult serous cancer ,serous tubal intraepithelial cancer (stic) ,brca1/2 pathogenic or likely pathogenic variant ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
We assessed the prevalence, localization, type and outcome of occult cancer at risk-reducing salpingo-oophorectomy or salpingectomy (RRSO) in asymptomatic carriers of pathogenic or likely pathogenic BRCA1/2 variants and high-risk BRCA1/2 negative women.
- Published
- 2020
- Full Text
- View/download PDF
30. Synthesis, crystal structure and biological activity of copper(II) complex with 4-nitro-3-pyrazolecarboxylic ligand
- Author
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Kosović Milica, Novaković Slađana, Jaćimović Željko, Latinović Nedeljko, Marković Nada, Đorđević Tamara, Libowitzky Eugen, and Giester Gerald
- Subjects
pyrazole ,copper (ii) ,coordination complexes ,crystal structure ,infrared spectra ,inhibition effect ,Chemistry ,QD1-999 - Abstract
The reaction of 4-nitro-3-pyrazolecarboxylic acid and Cu(OAc)2⋅H2O in ethanol resulted in a new coordination compound [Cu2(4-nitro-3- -pzc)2(H2O)6]2H2O (4nitro-3pzc = 4-nitro-3-pyrazolecarboxylate). The compound was investigated by means of single-crystal X-ray diffraction and infrared spectroscopy. The biological activity of the complex was also tested. In the crystal structure of [Cu2(4nitro-3-pzc)2(H2O)6]2H2O, the Cu(II) ion is in a distorted [4+2] octahedral coordination due to the Jan–Teller effect. A survey of the Cambridge Structural Database showed that the octahedral coordination geometry is generally rare for pyrazole-bridged Cu(II) complexes. In the case of Cu(II) complexes with the 3-pyrazolecarboxylato ligands, no complexes with a similar octahedral coordination geometry have been reported. Biological research based on determination of the inhibition effect of the commercial fungicide Cabrio top and the newly synthesized complex on Ph. viticola were performed using the phytosanitary method.
- Published
- 2020
- Full Text
- View/download PDF
31. Characterization of some Lead-Free Bronzes
- Author
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Živković, D., primary, Mitovski, A., additional, Novaković, S., additional, Balanović, Lj., additional, Marković, D., additional, and Marjanović, B., additional
- Published
- 2013
- Full Text
- View/download PDF
32. Geographical distribution of Slovenian BRCA1/2 families according to family origin: implications for genetic screening
- Author
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Krajc, M, primary, Zadnik, V, additional, Novaković, S, additional, Stegel, V, additional, Teugels, E, additional, Bešič, N, additional, Hočevar, M, additional, Vakselj, A, additional, De Grève, J, additional, and Žgajnar, J, additional
- Published
- 2013
- Full Text
- View/download PDF
33. Electronic properties of noncovalent interactions in [Co(fam)en]Cl complex
- Author
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Novaković, S. B., primary, Bogdanović, G. A., additional, Francuski, B. M., additional, Miodragović, D., additional, and Fraisse, B., additional
- Published
- 2011
- Full Text
- View/download PDF
34. Synthesis and crystal structure of s-cis-(ethylenediamine-N,N '-diacetato)cobalt(III) complex with N,N-dimethylglycine
- Author
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Dinovic, VM, Bogdanović, Goran A., Novaković, S, Sabo, Tibor, Dinovic, VM, Bogdanović, Goran A., Novaković, S, and Sabo, Tibor
- Abstract
The s-cis-geometrical isomer of the cobalt(III) complex with N,N-dimethylglycine (dmgly) and the tetradentate ligand ethylenediamine-N,N'-diacetate ion (edda) was prepared by a direct synthesis from cobalt(II) chloride hexahydrate, N,N-dimethylglycine and edda in the presence of lead(IV) oxide. The complex has been isolated chromatographically and characterized by elemental analyses, electron absorption spectra, infrared spectra and X-ray diffraction analysis.
- Published
- 2002
35. The role of leaders in creating an organizational culture that fosters the concept of preservation the natural resources
- Author
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Vujić Danijela, Karabašević Darjan, Maksimović Mlađan, and Novaković Srđan
- Subjects
leadership ,leader, organizational culture, natural resources ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Leadership becomes an important topic of research in the organizational theory as it is an essential factor for the success of organizations. Leadership can be understood as a process of influencing followers based on the clear values and beliefs. Organizational culture is largely evolving under the influence of leadership, and the culture of an organization in some segment can also affect the leadership. The efficient organizations in order to survive in increasingly competitive business conditions require a tactical and strategic thinking as well as the creation of a culture by the leader. Vision and mission of the organization can be realized only if the leader creates a culture dedicated to the support of this vision. Bearing in mind that the natural resources are a factor necessary for the functioning of societies in the modern world, the aim of the manuscript was to determine the role that a leader has in creating an organizational culture that fosters the concept of preserving the natural resources.
- Published
- 2019
- Full Text
- View/download PDF
36. The role of the leader in empowering and supporting employees towards sustainable development
- Author
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Vujić Danijela, Novaković Srđan, Maksimović Mlađan, and Karabašević Darjan
- Subjects
leaders ,leadership ,empowering ,sustainable development ,Military Science - Abstract
The modern world is moving from an industrial society towards a knowledge-based economy. In such a society, there is a need for inventive leaders, i.e. the leaders who will become the key comparative advantage of modern organizations. Therefore, in today's business conditions, more attention is paid to leadership. As a specialized management discipline, leadership is becoming the inevitable factor that has an impact on the business performance of organizations. Leadership can be seen as a process in which an individual influences the other members of the group in order to achieve common goals. Leadership should not be focused on one single position or one single individual, but on certain characteristics that have to be developed by all the members of the organization. Bearing in mind the fact that sustainable development is an important issue for mankind, as well as for organizations, the paper is aimed at determining the role that a leader has in empowering and supporting employees towards sustainable development.
- Published
- 2019
- Full Text
- View/download PDF
37. BRCA 1/2 mutations in a first cohort of 145 Slovenian breast/ovarian cancer families tested
- Author
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Krajc, M, primary, Teugels, E, additional, Žgajnar, J, additional, Besic, N, additional, Hocevar, M, additional, Novaković, S, additional, De Greve, J, additional, Bilban Jakopin, C, additional, Stegel, V, additional, Cirila Škufca Smrdel, A, additional, and Rener, M, additional
- Published
- 2007
- Full Text
- View/download PDF
38. BRCA gene mutations in Slovenian male breast cancer patients
- Author
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Besic, N, primary, Cernivc, B, additional, De Greve, J, additional, Lokar, K, additional, Krajc, M, additional, Novaković, S, additional, Žgajnar, J, additional, and Teugels, E, additional
- Published
- 2007
- Full Text
- View/download PDF
39. P063 Mechanisms of action of rituximab and its effectiveness in high risk patients with aggressive CD20+ lymphoma
- Author
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Jezersek Novaković, B., primary, Kotnik, V., additional, Južnič Šetina, T., additional, Vovk, M., additional, and Novaković, S., additional
- Published
- 2007
- Full Text
- View/download PDF
40. Experimental charge density study of (E)-4-(2,4-diisopropylphenyl)-4-oxo-2-butenoic acid
- Author
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Novaković, S. B., primary, Bogdanović, G. A., additional, Drakulić, B. J., additional, Spasojević-de Biré, A., additional, and Juranić, I. O., additional
- Published
- 2007
- Full Text
- View/download PDF
41. Specific T cell responses to Helicobacter pylori predict successful eradication therapy
- Author
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Kopitar, A.N., primary, Stegel, V., additional, Tepeš, B., additional, Gubina, M., additional, Novaković, S., additional, and Ihan, A., additional
- Published
- 2007
- Full Text
- View/download PDF
42. Randomised trial of HPV self-sampling among non-attenders in the Slovenian cervical screening programme ZORA: comparing three different screening approaches
- Author
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Ivanus Urska, Jerman Tine, Fokter Alenka Repse, Takac Iztok, Prevodnik Veronika Kloboves, Marcec Mateja, Gajsek Ursula Salobir, Pakiz Maja, Koren Jakob, Celik Simona Hutter, Kramberger Kristina Gornik, Klopcic Ulrika, Kavalar Rajko, Zatler Simona Sramek, Kuzmanov Biljana Grcar, Florjancic Mojca, Nolde Natasa, Novakovic Srdjan, Poljak Mario, and Zakelj Maja Primic
- Subjects
cervical cancer ,screening programme ,non-attenders ,cytology ,hpv ,self-sampling ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
To overcome obstacles within the Slovenian organised cervical cancer screening programme, a randomised pilot study of human papillomavirus (HPV) self-sampling among non-attenders was performed, aiming to assess three different screening approaches.
- Published
- 2018
- Full Text
- View/download PDF
43. Prevalence of BRAF, NRAS and c-KIT mutations in Slovenian patients with advanced melanoma
- Author
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Moltara Maja Ebert, Novakovic Srdjan, Boc Marko, Bucic Marina, Rebersek Martina, Zadnik Vesna, and Ocvirk Janja
- Subjects
braf ,nras ,c-kit ,prevalence ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
BRAF, NRAS and c-KIT mutations are characteristics of tumour tissues that influence on treatment decisions in metastatic melanoma patients. Mutation frequency and their correlation with histological characteristics in Slovenian population have not been investigated yet.
- Published
- 2018
- Full Text
- View/download PDF
44. Examination of leadership styles in organizations in Serbia which in its operations apply the concept of preserving the natural resources
- Author
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Vujić Danijela, Novaković Srđan, Maksimović Mlađan, and Karabašević Darjan
- Subjects
leadership ,natural resources ,leadership styles ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Leadership becomes an important topic of research in the organizational theory as it is an essential factor for success of organizations. Leadership can be understood as a process of influencing followers based on clear values and beliefs. Leaders, based on their own power, create trust in the organization and desire for followers to achieve the goals of both the group and organization. Bearing in mind that the natural resources are a factor necessary for functioning the societies in the modern world, the main goal of this paper is to determine the leadership styles in organizations that apply the concept of preservation the natural resources in their operations.
- Published
- 2018
- Full Text
- View/download PDF
45. Selection of production lines in the metallurgical industry using the Compromise Programming method
- Author
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Radivojević Srbislav, Maksimović Mlađan, Karabašević Darjan, and Novaković Srđan
- Subjects
metallurgical industry ,production lines ,mcdm ,compromise programming ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Every organization today faces the problem of decision making. In this regard, the intent of this paper is to present an approach based on the multi-criteria decision-making methods. Primarily, the proposed approach is aimed to help solving problem of choosing the optimal production lines in the metallurgical industry. The proposed approach is based on the use of the AHP method for determining the weights of criteria, whereas the Compromise Programming is used for selection the alternatives. The usability, applicability and efficiency of the proposed approach is demonstrated in a conducted case study of selection the production lines in the metallurgical industry.
- Published
- 2018
- Full Text
- View/download PDF
46. Internal audit in the function of management
- Author
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Novaković Srđan, Jovićević Predrag, and Simin Marina
- Subjects
internal audit ,management ,business management ,business decision making ,research ,Commerce ,HF1-6182 ,Finance ,HG1-9999 - Abstract
In modern business conditions, more and more attention is paid to the introduction of internal audit in our everyday practice and its development and improvement. In this context, the question arises whether the level of development of internal audit in enterprises in the Republic of Serbia corresponds with the achieved degree of development of that profession in the countries of a developed market economy, as well as the role of internal audit in the function of management that manages the enterprise. This issue is also a fundamental problem of this research. The aim of the research is to theoretically and empirically process the relationship between internal audit and enterprise management and to investigate the degree of development of internal audit in enterprises operating in the Republic of Serbia. Empirical research provides answers to the key questions that are the foundation of the research itself, which is: Does internal audit contribute to the improvement of business management? The results of the conducted empirical research point to the conclusion that internal audit contributes to the improvement of business management in companies in the Republic of Serbia. but also point to slow development of internal audit as a profession.
- Published
- 2018
47. Managing agricultural company by using internal control and significance of risk presentation
- Author
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Novaković Srećko, Vukasović Dragan, Laban Bogdan, Ivić Mladen, Popović Vera, and Popović Slobodan
- Subjects
managing ,risk ,internal control ,Agriculture - Abstract
The survival of a company on the market is possible if there is a good company managing, led by agile and professional management. Company development is a general objective and it can be achieved if the management of the company managed to establish their own style of organization and management. In addition to the aforesaid, the management should have a developed system of internal control within the regular and continuous business operations. Our contribution is reflected in the presentation of mode of managing nursery-garden plant production, using internal control for the benefits of management. We found that the application of detected risks in said production could be presented and illustrated in a range of risks, all of it with the aim of making management decisions that will reduce the overall risk of an agricultural company's business operations.
- Published
- 2018
48. 2-Acetylpyrydine-aminoguanidine Schiff base – Novel ligand salt and zinc(II) complex containing thiocyanate
- Author
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Radanović Mirjana M., Novaković Slađana B., Vojinović-Ješić Ljiljana S., Rodić Marko V., and Leovac Vukadin M.
- Subjects
Schiff base ,crystal structure ,physico-chemical characterization ,metal complexes ,Chemistry ,QD1-999 - Abstract
A new salt of Schiff base of aminoguanidine and 2-acetylpyridine, and its zinc(II) complex were obtained and their physicochemical and structural properties studied. The reaction of an aqueous solution of the chloride ligand salt and NH4NCS resulted in formation of the dithiocyanate ligand salt, L·2HNCS, while the reaction of the obtained salt with zinc(II) acetate gave a neutral complex of the formula [ZnL(NCS)2]. In this complex, chelate ligand is coordinated in its neutral form, in a common tridentate NNN manner, via pyridine, azomethine and imino nitrogen atoms of the aminoguanidine fragment. This coordination mode results in formation of two strained five-membered metallocycles. Zinc(II) is situated in a distorted square-pyramidal environment of the tridentate ligand and one thiocyanate ion in the equatorial and the other thiocyanate ion in the apical position. The crystal structure of the ligand salt is stabilized by N–H…N and N–H…S interactions formed between the cationic and anionic species, while the three-dimensional crystal packing of the complex units is based on weak N–H…S interactions which involve the S acceptors from both NCS ligands. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172014]
- Published
- 2018
- Full Text
- View/download PDF
49. Clinical evaluation of potential usefulness of CEA, CA 15-3, and MCA in follow-up of breast cancer patients
- Author
-
Jezeršek, B., primary, Červek, J., additional, Rudolf, Z., additional, and Novaković, S., additional
- Published
- 1996
- Full Text
- View/download PDF
50. The influence of TNF on the membrane fluidity of tumor cells
- Author
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Štalc, A., primary, Šentjurc, M., additional, Serša, G., additional, and Novaković, S., additional
- Published
- 1992
- Full Text
- View/download PDF
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