721 results on '"Novak G"'
Search Results
2. Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer’s subjects from the Alzheimer’s Disease Neuroimaging Initiative
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Samtani MN, Raghavan N, Novak G, Nandy P, and Narayan VA
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Mahesh N Samtani, Nandini Raghavan, Gerald Novak, Partha Nandy, Vaibhav A Narayan On behalf of the Alzheimer’s disease Neuroimaging Initiative Janssen Research and Development, LLC, Raritan, New Jersey, USA Background: The objective of this analysis was to develop a nonlinear disease progression model, using an expanded set of covariates that captures the longitudinal Clinical Dementia Rating Scale–Sum of Boxes (CDR–SB) scores. These were derived from the Alzheimer’s disease Neuroimaging Initiative ADNI-1 study, of 301 Alzheimer’s disease and mild cognitive impairment patients who were followed for 2–3 years. Methods: The model describes progression rate and baseline disease score as a function of covariates. The covariates that were tested fell into five groups: a) hippocampal volume; b) serum and cerebrospinal fluid (CSF) biomarkers; c) demographics and apolipoprotein Epsilon 4 (ApoE4) allele status; d) baseline cognitive tests; and e) disease state and comedications. Results: Covariates associated with baseline disease severity were disease state, hippocampal volume, and comedication use. Disease progression rate was influenced by baseline CSF biomarkers, Trail-Making Test part A score, delayed logical memory test score, and current level of impairment as measured by CDR–SB. The rate of disease progression was dependent on disease severity, with intermediate scores around the inflection point score of 10 exhibiting high disease progression rate. The CDR–SB disease progression rate in a typical patient, with late mild cognitive impairment and mild Alzheimer’s disease, was estimated to be approximately 0.5 and 1.4 points/year, respectively. Conclusions: In conclusion, this model describes disease progression in terms of CDR–SB changes in patients and its dependency on novel covariates. The CSF biomarkers included in the model discriminate mild cognitive impairment subjects as progressors and nonprogressors. Therefore, the model may be utilized for optimizing study designs, through patient population enrichment and clinical trial simulations. Keywords: NONMEM®, beta-regression, CSF Aß1–42, hippocampal volume, trial enrichment
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- 2014
3. The role of the magnetic field in the fragmentation process: the case of G14.225-0.506
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Añez-López, N., Busquet, G., Koch, P. M., Girart, J. M., Liu, H. B., Santos, F., Chapman, N. L., Novak, G., Palau, A., Ho, P. T. P., and Zhang, Q.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
B-fields are predicted to play a role in the formation of filamentary structures and their fragmentation process. We aim at investigating the role of the B-field in the process of core fragmentation toward the hub-filament systems in the IRDC G14.2, which present different fragmentation level. We performed observations of the thermal dust polarization at 350 {\mu}m using the CSO toward the hubs. We applied the polarization--intensity-gradient method to estimate the significance of the B-field over the G-force. The B-field in Hub-N shows a uniform structure along the E-W orientation, perpendicular to the major axis of the hub-filament system. The I-gradient in Hub-N displays a local minimum coinciding with the dust core MM1a detected with interferometric observations. The B-field orientation is perturbed when approaching the dust core. Hub-S shows 2 local minima, reflecting the bimodal distribution of the B-field. In Hub-N, both E and W of the hub-filament system, the I-gradient and the B-field are parallel whereas they tend to be perpendicular when penetrating the filaments and hub. The analysis of the {\delta}- and {\Sigma} B-maps indicate that, the B-field cannot prevent the collapse, suggesting that the B-field is initially dragged by the infalling motion and aligned with it, or is channeling material toward the central ridge from both sides. Values of {\Sigma} B > 1 are found toward a N-S ridge encompassing the dust emission peak, indicating that in this region B-field dominates over G-force, or that with the current angular resolution we cannot resolve an hypothetical more complex structure. We estimated the B-field strength, the MtF ratio and the A-M number, and found differences between the 2 hubs. The different levels of fragmentation observed in these 2 hubs could arise from the differences in the B-field properties rather than from different intensity of the G-field., Comment: 14 pages, 9 figures
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- 2020
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4. PICO: Probe of Inflation and Cosmic Origins
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Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., and Zonca, A.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,High Energy Physics - Theory - Abstract
The Probe of Inflation and Cosmic Origins (PICO) is a proposed probe-scale space mission consisting of an imaging polarimeter operating in frequency bands between 20 and 800 GHz. We describe the science achievable by PICO, which has sensitivity equivalent to more than 3300 Planck missions, the technical implementation, the schedule and cost., Comment: APC White Paper submitted to the Astro2020 decadal panel; 10 page version of the 50 page mission study report arXiv:1902.10541
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- 2019
5. SOFIA/HAWC+ traces the magnetic fields in NGC 1068
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Lopez-Rodriguez, E., Dowell, C. D., Jones, T. J., Harper, D. A., Berthoud, M., Chuss, D., Dale, D. A., Guerra, J. A., Hamilton, R. T., Looney, L. W., Michail, J. M., Nikutta, R., Novak, G., Santos, F. P., Sheth, K., Siah, J., Staguhn, J., Stephens, I. W., Tassis, K., Trinh, C. Q., Ward-Thompson, D., Werner, M., Wollack, E. J., and Zweibel, E.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report the first detection of galactic spiral structure by means of thermal emission from magnetically aligned dust grains. Our 89 $\mu$m polarimetric imaging of NGC 1068 with the High-resolution Airborne Wideband Camera/Polarimeter (HAWC+) on NASA's Stratospheric Observatory for Infrared Astronomy (SOFIA) also sheds light on magnetic field structure in the vicinity of the galaxy's inner-bar and active galactic nucleus (AGN). We find correlations between the 89 $\mu$m magnetic field vectors and other tracers of spiral arms, and a symmetric polarization pattern as a function of the azimuthal angle arising from the projection and inclination of the disk field component in the plane of the sky. The observations can be fit with a logarithmic spiral model with pitch angle of $16.9^{+2.7}_{-2.8}$$^{\circ}$ and a disk inclination of $48\pm2^{\circ}$. We infer that the bulk of the interstellar medium from which the polarized dust emission originates is threaded by a magnetic field that closely follows the spiral arms. Inside the central starburst disk ($<1.6$ kpc), the degree of polarization is found to be lower than for far-infrared sources in the Milky Way, and has minima at the locations of most intense star formation near the outer ends of the inner-bar. Inside the starburst ring, the field direction deviates from the model, becoming more radial along the leading edges of the inner-bar. The polarized flux and dust temperature peak $\sim 3-6$" NE of the AGN at the location of a bow shock between the AGN outflow and the surrounding interstellar medium, but the AGN itself is weakly polarized ($< 1$%) at both 53 and 89 \um., Comment: 13 pages, 7 figures, Accepted for publication by ApJ
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- 2019
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6. Sensitivity of the Preclinical Alzheimer’s Cognitive Composite (PACC), PACC5, and Repeatable Battery for Neuropsychological Status (RBANS) to Amyloid Status in Preclinical Alzheimer’s Disease -Atabecestat Phase 2b/3 EARLY Clinical Trial
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Papp, Kathryn V., Rofael, H., Veroff, A. E., Donohue, M. C., Wang, S., Randolph, C., Grober, E., Brashear, H. Robert, Novak, G., Ernstrom, K., Raman, R., Aisen, P. S., Sperling, R., Romano, Gary, and Henley, David
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- 2022
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7. Measuring filament orientation: a new quantitative, local approach
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Green, C. -E., Dawson, J. R., Cunningham, M. R., Jones, P. A., Novak, G., and Fissel, L. M.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The relative orientation between filamentary structures in molecular clouds and the ambient magnetic field provides insight into filament formation and stability. To calculate the relative orientation, a measurement of filament orientation is first required. We propose a new method to calculate the orientation of the one pixel wide filament skeleton that is output by filament identification algorithms such as \textsc{filfinder}. We derive the local filament orientation from the direction of the intensity gradient in the skeleton image using the Sobel filter and a few simple post-processing steps. We call this the `Sobel-gradient method'. The resulting filament orientation map can be compared quantitatively on a local scale with the magnetic field orientation map to then find the relative orientation of the filament with respect to the magnetic field at each point along the filament. It can also be used in constructing radial profiles for filament width fitting. The proposed method facilitates automation in analysis of filament skeletons, which is imperative in this era of `big data'., Comment: 12 pages, 7 figures. Accepted for publication in ApJS, August 2017
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- 2017
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8. Removing visual bias in filament identification: a new goodness-of-fit measure
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Green, C. -E., Cunningham, M. R., Dawson, J. R., Jones, P. A., Novak, G., and Fissel, L. M.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Different combinations of input parameters to filament identification algorithms, such as Disperse and FilFinder, produce numerous different output skeletons. The skeletons are a one pixel wide representation of the filamentary structure in the original input image. However, these output skeletons may not necessarily be a good representation of that structure. Furthermore, a given skeleton may not be as good a representation as another. Previously there has been no mathematical `goodness-of-fit' measure to compare output skeletons to the input image. Thus far this has been assessed visually, introducing visual bias. We propose the application of the mean structural similarity index (MSSIM) as a mathematical goodness-of-fit measure. We describe the use of the MSSIM to find the output skeletons most mathematically similar to the original input image (the optimum, or `best', skeletons) for a given algorithm, and independently of the algorithm. This measure makes possible systematic parameter studies, aimed at finding the subset of input parameter values returning optimum skeletons. It can also be applied to the output of non-skeleton based filament identification algorithms, such as the Hessian matrix method. The MSSIM removes the need to visually examine thousands of output skeletons, and eliminates the visual bias, subjectivity, and limited reproducibility inherent in that process, representing a major improvement on existing techniques. Importantly, it also allows further automation in the post-processing of output skeletons, which is crucial in this era of `big data'., Comment: 8 pages, 3 figures, Accepted for publication in ApJL, April 2017
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- 2017
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9. On the relation between the column density structures and the magnetic field orientation in the Vela C molecular complex
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Soler, J. D., Ade, P. A. R., Angilè, F. E., Ashton, P., Benton, S. J., Devlin, M. J., Dober, B., Fissel, L. M., Fukui, Y., Galitzki, N., Gandilo, N. N., Hennebelle, P., Klein, J., Li, Z. -Y., Korotkov, A. L., Martin, P. G., Matthews, T. G., Moncelsi, L., Netterfield, C. B., Novak, G., Pascale, E., Poidevin, F., Santos, F. P., Savini, G., Scott, D., Shariff, J. A., Thomas, N. E., Tucker, C. E., Tucker, G. S., and Ward-Thompson, D.
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Astrophysics - Astrophysics of Galaxies - Abstract
We statistically evaluate the relative orientation between gas column density structures, inferred from Herschel submillimetre observations, and the magnetic field projected on the plane of sky, inferred from polarized thermal emission of Galactic dust observed by BLASTPol at 250, 350, and 500 micron, towards the Vela C molecular complex. First, we find very good agreement between the polarization orientations in the three wavelength-bands, suggesting that, at the considered common angular resolution of 3.0 arcminutes that corresponds to a physical scale of approximately 0.61 pc, the inferred magnetic field orientation is not significantly affected by temperature or dust grain alignment effects. Second, we find that the relative orientation between gas column density structures and the magnetic field changes progressively with increasing gas column density, from mostly parallel or having no preferred orientation at low column densities to mostly perpendicular at the highest column densities. This observation is in agreement with previous studies by the Planck collaboration towards more nearby molecular clouds. Finally, we find a correspondence between the trends in relative orientation and the shape of the column density probability distribution functions. In the sub-regions of Vela C dominated by one clear filamentary structure, or "ridges", we find a sharp transition from preferentially parallel or having no preferred relative orientation at low column densities to preferentially perpendicular at highest column densities. In the sub-regions of Vela C dominated by several filamentary structures with multiple orientations, or "nests", such a transition is also present, but it is clearly less sharp than in the ridge-like sub-regions. Both of these results suggest that the magnetic field is dynamically important for the formation of density structures in this region., Comment: 16 pages, 17 figures. Submitted to A&A
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- 2017
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10. Blood Derived Amyloid Biomarkers for Alzheimer’s Disease Prevention
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Udeh-Momoh, C., Zheng, B., Sandebring-Matton, A., Novak, G., Kivipelto, M., Jönsson, L., and Middleton, Lefkos
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- 2022
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11. AGN feedback and star formation in ETGs: negative and positive feedback
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Ciotti, L., Ostriker, J. P., Negri, A., Pellegrini, S., Posacki, S., and Novak, G.
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Astrophysics - Astrophysics of Galaxies - Abstract
AGN feedback from supermassive black holes (SMBHs) at the center of early type galaxies is commonly invoked as the explanation for the quenching of star formation in these systems. The situation is complicated by the significant amount of mass injected in the galaxy by the evolving stellar population over cosmological times. In absence of feedback, this mass would lead to unobserved galactic cooling flows, and to SMBHs two orders of magnitude more massive than observed. By using high-resolution 2D hydrodynamical simulations with radiative transport and star formation in state-of-the-art galaxy models, we show how the intermittent AGN feedback is highly structured on spatial and temporal scales, and how its effects are not only negative (shutting down the recurrent cooling episodes of the ISM), but also positive, inducing star formation in the inner regions of the host galaxy., Comment: 4 pages, 1 figure, to appear in Proceedings of IAU Symposium 315 "From interstellar clouds to star-forming galaxies: universal processes?", P. Jablonka, F. van der Tak and P. Andre', eds. - Correction of affiliations
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- 2015
12. Tracing H2 column density with atomic carbon (CI) and CO isotopologues
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Lo, N., Cunningham, M. R., Jones, P. A., Bronfman, L., Cortes, P. C., Simon, R., Lowe, V., Fissel, L., and Novak, G.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present first results of neutral carbon ([CI], 3P1 - 3P0 at 492 GHz) and carbon monoxide (13CO, J = 1 - 0) mapping in the Vela Molecular Ridge cloud C (VMR-C) and G333 giant molecular cloud complexes with the NANTEN2 and Mopra telescopes. For the four regions mapped in this work, we find that [CI] has very similar spectral emission profiles to 13CO, with comparable line widths. We find that [CI] has opacity of 0.1 - 1.3 across the mapped region while the [CI]/13CO peak brightness temperature ratio is between 0.2 to 0.8. The [CI] column density is an order of magnitude lower than that of 13CO. The H2 column density derived from [CI] is comparable to values obtained from 12CO. Our maps show CI is preferentially detected in gas with low temperatures (below 20 K), which possibly explains the comparable H2 column density calculated from both tracers (both CI and 12CO underestimate column density), as a significant amount of the CI in the warmer gas is likely in the higher energy state transition ([CI], 3P2 - 3P1 at 810 GHz), and thus it is likely that observations of both the above [CI] transitions are needed in order to recover the total H2 column density., Comment: accepted for publication in ApJ Letters
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- 2014
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13. P784 Efficacy of ustekinumab in biologically naïve patients with Inflammatory Bowel Disease
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Šubic, Ž, primary and Novak, G, additional
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- 2024
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14. Testing Magnetic Field Models for the Class 0 Protostar L1527
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Davidson, J. A., Li, Z. -Y., Hull, C. L. H., Plambeck, R. L., Kwon, W., Crutcher, R. M., Looney, L. W., Novak, G., Chapman, N. L., Matthews, B. C., Stephens, I. W., Tobin, J. J., and Jones, T. J.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
For the Class 0 protostar, L1527, we compare 131 polarization vectors from SCUPOL/JCMT, SHARP/CSO and TADPOL/CARMA observations with the corresponding model polarization vectors of four ideal-MHD, non-turbulent, cloud core collapse models. These four models differ by their initial magnetic fields before collapse; two initially have aligned fields (strong and weak) and two initially have orthogonal fields (strong and weak) with respect to the rotation axis of the L1527 core. Only the initial weak orthogonal field model produces the observed circumstellar disk within L1527. This is a characteristic of nearly all ideal-MHD, non-turbulent, core collapse models. In this paper we test whether this weak orthogonal model also has the best agreement between its magnetic field structure and that inferred from the polarimetry observations of L1527. We found that this is not the case; based on the polarimetry observations the most favored model of the four is the weak aligned model. However, this model does not produce a circumstellar disk, so our result implies that a non-turbulent, ideal-MHD global collapse model probably does not represent the core collapse that has occurred in L1527. Our study also illustrates the importance of using polarization vectors covering a large area of a cloud core to determine the initial magnetic field orientation before collapse; the inner core magnetic field structure can be highly altered by a collapse and so measurements from this region alone can give unreliable estimates of the initial field configuration before collapse., Comment: 43 pages, 9 figures, 4 tables. Accepted by the Astrophysical Journal
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- 2014
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15. Simulating multiple merger pathways to the central kinematics of early-type galaxies
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Moody, Christopher E., Romanowsky, Aaron J., Cox, Thomas J., Novak, G. S., and Primack, Joel R.
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Astrophysics - Astrophysics of Galaxies - Abstract
Two-dimensional integral field surveys such as ATLAS^3D are producing rich observational data sets yielding insights into galaxy formation. These new kinematic observations have highlighted the need to understand the evolutionary mechanisms leading to a spectrum of fast-rotators and slow-rotators in early-type galaxies. We address the formation of slow and fast rotators through a series of controlled, comprehensive hydrodynamical simulations sampling idealized galaxy merger scenarios constructed from model spiral galaxies. Idealized and controlled simulations of this sort complement the more 'realistic' cosmological simulations by isolating and analyzing the effects of specific parameters, as we do in this paper. We recreate minor and major binary mergers, binary merger trees with multiple progenitors, and multiple sequential mergers. Within each of these categories of formation history, we correlate progenitor gas fraction, mass ratio, orbital pericenter, orbital ellipticity, and spin with remnant kinematic properties. We create kinematic profiles of these 95 simulations comparable to ATLAS^3D data. By constructing remnant profiles of the projected specific angular momentum (lambda_R =
/ , triaxiality, and measuring the incidences of kinematic twists and kinematically decoupled cores, we distinguish between varying formation scenarios. We find that binary mergers nearly always form fast rotators. Slow rotators can be formed from zero initial angular momentum configurations and gas-poor mergers, but are not as round as the ATLAS^3D galaxies. Remnants of binary merger trees are triaxial slow rotators. Sequential mergers form round slow rotators that most resemble the ATLAS^3D rotators., Comment: MNRAS, in press, 12 pages, 15 figures - Published
- 2014
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16. The Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry-BLASTPol: Performance and results from the 2012 Antarctic flight
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Galitzki, N., Ade, P. A. R., Angilé, F. E., Benton, S. J., Devlin, M. J., Dober, B., Fissel, L. M., Fukui, Y., Gandilo, N. N., Klein, J., Korotkov, A. L., Matthews, T. G., Moncelsi, L., Netterfield, C. B., Novak, G., Nutter, D., Pascale, E., Poidevin, F., Savini, G., Scott, D., Shariff, J. A., Soler, J. D., Tucker, C. E., Tucker, G. S., and Ward-Thompson, D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry (BLASTPol) is a suborbital mapping experiment, designed to study the role played by magnetic fields in the star formation process. BLASTPol observes polarized light using a total power instrument, photolithographic polarizing grids, and an achromatic half-wave plate to modulate the polarization signal. During its second flight from Antarctica in December 2012, BLASTPol made degree scale maps of linearly polarized dust emission from molecular clouds in three wavebands, centered at 250, 350, and 500 microns. The instrumental performance was an improvement over the 2010 BLASTPol flight, with decreased systematics resulting in a higher number of confirmed polarization vectors. The resultant dataset allows BLASTPol to trace magnetic fields in star-forming regions at scales ranging from cores to entire molecular cloud complexes., Comment: Presented at SPIE Ground-based and Airborne Telescopes V, June 23, 2014
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- 2014
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17. Thermal design and performance of the balloon-borne large aperture submillimeter telescope for polarimetry BLASTPol
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Soler, J. D., Ade, P. A. R., Angilè, F. E., Benton, S. J., Devlin, M. J., Dober, B., Fissel, L. M., Fukui, Y., Galitzki, N., Gandilo, N. N., Klein, J., Korotkov, A. L., Matthews, T. G., Moncelsi, L., Mroczkowski, A., Netterfield, C. B., Novak, G., Nutter, D., Pascale, E., Poidevin, F., Savini, G., Scott, D., Shariff, J. A., Thomas, N. E., Truch, M. D., Tucker, C. E., Tucker, G. S., and Ward-Thompson, D.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the thermal model of the Balloon-borne Large-Aperture Submillimeter Telescope for Polarimetry (BLASTPol). This instrument was successfully flown in two circumpolar flights from McMurdo, Antarctica in 2010 and 2012. During these two flights, BLASTPol obtained unprecedented information about the magnetic field in molecular clouds through the measurement of the polarized thermal emission of interstellar dust grains. The thermal design of the experiment addresses the stability and control of the payload necessary for this kind of measurement. We describe the thermal modeling of the payload including the sun-shielding strategy. We present the in-flight thermal performance of the instrument and compare the predictions of the model with the temperatures registered during the flight. We describe the difficulties of modeling the thermal behavior of the balloon-borne platform and establish landmarks that can be used in the design of future balloon-borne instruments., Comment: 18 pages, 11 figures. Presented at SPIE Ground-based and Airborne Telescopes V, June 23, 2014. To be published in Proceedings of SPIE Volume 9145
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- 2014
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18. BLASTbus electronics: general-purpose readout and control for balloon-borne experiments
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Benton, S. J., Ade, P. A., Amiri, M., Angilè, F. E., Bock, J. J., Bond, J. R., Bryan, S. A., Chiang, H. C., Contaldi, C. R., Crill, B. P., Devlin, M. J., Dober, B., Doré, O. P., Dowell, C. D., Farhang, M., Filippini, J. P., Fissel, L. M., Fraisse, A. A., Fukui, Y., Galitzki, N., Gambrel, A. E., Gandilo, N. N., Golwala, S. R., Gudmundsson, J. E., Halpern, M., Hasselfield, M., Hilton, G. C., Holmes, W. A., Hristov, V. V., Irwin, K. D., Jones, W. C., Kermish, Z. D., Klein, J., Korotkov, A. L., Kuo, C. L., MacTavish, C. J., Mason, P. V., Matthews, T. G., Megerian, K. G., Moncelsi, L., Morford, T. A., Mroczkowski, T. K., Nagy, J. M., Netterfield, C. B., Novak, G., Nutter, D., O'Brient, R., Ogburn IV, R. W., Pascale, E., Poidevin, F., Rahlin, A. S., Reintsema, C. D., Ruhl, J. E., Runyan, M. C., Savini, G., Scott, D., Shariff, J. A., Soler, J. D., Thomas, N. E., Trangsrud, A., Truch, M. D., Tucker, C. E., Tucker, G. S., Tucker, R. S., Turner, A. D., Ward-Thompson, D., Weber, A. C., Wiebe, D. V., and Young, E. Y.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present the second generation BLASTbus electronics. The primary purposes of this system are detector readout, attitude control, and cryogenic housekeeping, for balloon-borne telescopes. Readout of neutron transmutation doped germanium (NTD-Ge) bolometers requires low noise and parallel acquisition of hundreds of analog signals. Controlling a telescope's attitude requires the capability to interface to a wide variety of sensors and motors, and to use them together in a fast, closed loop. To achieve these different goals, the BLASTbus system employs a flexible motherboard-daughterboard architecture. The programmable motherboard features a digital signal processor (DSP) and field-programmable gate array (FPGA), as well as slots for three daughterboards. The daughterboards provide the interface to the outside world, with versions for analog to digital conversion, and optoisolated digital input/output. With the versatility afforded by this design, the BLASTbus also finds uses in cryogenic, thermometry, and power systems. For accurate timing control to tie everything together, the system operates in a fully synchronous manner. BLASTbus electronics have been successfully deployed to the South Pole, and flown on stratospheric balloons., Comment: Presented at SPIE Ground-based and Airborne Telescopes V, June 23, 2014. To be published in Proceedings of SPIE Volume 9145
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- 2014
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19. Attitude determination for balloon-borne experiments
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Gandilo, N. N., Ade, P. A. R., Amiri, M., Angile, F. E., Benton, S. J., Bock, J. J., Bond, J. R., Bryan, S. A., Chiang, H. C., Contaldi, C. R., Crill, B. P., Devlin, M. J., Dober, B., Dore, O. P., Farhang, M., Filippini, J. P., Fissel, L. M., Fraisse, A. A., Fukui, Y., Galitzki, N., Gambrel, A. E., Golwala, S., Gudmundsson, J. E., Halpern, M., Hasselfield, M., Hilton, G. C., Holmes, W. A., Hristov, V. V., Irwin, K. D., Jones, W. C., Kermish, Z. D., Klein, J., Korotkov, A. L., Kuo, C. L., MacTavish, C. J., Mason, P. V., Matthews, T. G., Megerian, K. G., Moncelsi, L., Morford, T. A., Mroczkowski, T. K., Nagy, J. M., Netterfield, C. B., Novak, G., Nutter, D., O'Brient, R., Pascale, E., Poidevin, F., Rahlin, A. S., Reintsema, C. D., Ruhl, J. E., Runyan, M. C., Savini, G., Scott, D., Shariff, J. A., Soler, J. D., Thomas, N. E., Trangsrud, A., Truch, M. D., Tucker, C. E., Tucker, G. S., Tucker, R. S., Turner, A. D., Ward-Thompson, D., Weber, A. C., Wiebe, D. V., and Young, E. Y.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
An attitude determination system for balloon-borne experiments is presented. The system provides pointing information in azimuth and elevation for instruments flying on stratospheric balloons over Antarctica. In-flight attitude is given by the real-time combination of readings from star cameras, a magnetometer, sun sensors, GPS, gyroscopes, tilt sensors and an elevation encoder. Post-flight attitude reconstruction is determined from star camera solutions, interpolated by the gyroscopes using an extended Kalman Filter. The multi-sensor system was employed by the Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry (BLASTPol), an experiment that measures polarized thermal emission from interstellar dust clouds. A similar system was designed for the upcoming flight of SPIDER, a Cosmic Microwave Background polarization experiment. The pointing requirements for these experiments are discussed, as well as the challenges in designing attitude reconstruction systems for high altitude balloon flights. In the 2010 and 2012 BLASTPol flights from McMurdo Station, Antarctica, the system demonstrated an accuracy of <5' rms in-flight, and <5" rms post-flight., Comment: 16 pages, 10 figures, Presented at SPIE Ground-based and Airborne Telescopes V, June 23, 2014. To be published in Proceedings of SPIE Volume 9145
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- 2014
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20. Comparison of Prestellar Core Elongations and Large-Scale Molecular Cloud Structures in the Lupus I Region
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Poidevin, F., Ade, P. A. R., Angile, F. E., Benton, S. J., Chapin, E. L., Devlin, M. J., Fissel, L. M., Fukui, Y., Gandilo, N. N., Gundersen, J. O., Hargrave, P. C., Klein, J., Korotkov, A. L., Matthews, T. G., Moncelsi, L., Mroczkowski, T. K., Netterfield, C. B., Novak, G., Nutter, D., Olmi, L., Pascale, E., Savini, G., Scott, D., Shariff, J. A., Soler, J. D., Tachihara, K., Thomas, N. E., Truch, M. D. P., Tucker, C. E., Tucker, G. S., and Ward-Thompson, D.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Turbulence and magnetic fields are expected to be important for regulating molecular cloud formation and evolution. However, their effects on subparsec to 100 parsec scales, leading to the formation of starless cores, is not well understood. We investigate the prestellar core structure morphologies obtained from analysis of the Herschel-SPIRE 350 $\mu$m maps of the Lupus I cloud. This distribution is first compared on a statistical basis to the large scale shape of the main filament. We find the distribution of the elongation position angle of the cores to be consistent with a random distribution, which means no specific orientation of the morphology of the cores is observed with respect to a large-scale filament shape model for Lupus I, or relative to a large-scale bent filament model. This distribution is also compared to the mean orientation of the large-scale magnetic fields probed at 350 $\mu$m with the Balloon-borne Large Aperture Telescope for Polarimetry (BLASTPol) during its 2010 campaign. Here again we do not find any correlation between the core morphology distribution and the average orientation of the magnetic fields on parsec scales. Our main conclusion is that the local filament dynamics - including secondary filaments that often run orthogonally to the primary filament - and possibly small-scale variations in the local magnetic field direction, could be the dominant factors for explaining the final orientation of each core., Comment: 11 pages, 7 figures, 2 tables
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- 2014
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21. Heating of the molecular gas in the massive outflow of the local ultraluminous-infrared and radio-loud galaxy 4C12.50
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Dasyra, K. M., Combes, F., Novak, G. S., Bremer, M., Spinoglio, L., Santaella, M. Pereira, Salome, P., and Falgarone, E.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present a comparison of the molecular gas properties in the outflow vs. in the ambient medium of the local prototype radio-loud and ultraluminous-infrared galaxy 4C12.50 (IRAS13451+1232), using new data from the IRAM Plateau de Bure interferometer and 30m telescope, and the Herschel space telescope. Previous H_2 (0-0) S(1) and S(2) observations with the Spitzer space telescope had indicated that the warm (~400K) molecular gas in 4C12.50 is made up of a 1.4(+-0.2)x10^8 M_sun ambient reservoir and a 5.2(+-1.7)x10^7 M_sun outflow. The new CO(1-0) data cube indicates that the corresponding cold (25K) H_2 gas mass is 1.0(+-0.1)x10^10 M_sun for the ambient medium and <1.3x10^8 M_sun for the outflow, when using a CO-intensity-to-H_2-mass conversion factor alpha of 0.8 M_sun /(K km/s pc^2). The combined mass outflow rate is high, 230-800 M_sun/yr, but the amount of gas that could escape the galaxy is low. A potential inflow of gas from a 3.3(+-0.3)x10^8 M_sun tidal tail could moderate any mass loss. The mass ratio of warm-to-cold molecular gas is >= 30 times higher in the outflow than in the ambient medium, indicating that a non-negligible fraction of the accelerated gas is heated to temperatures at which star formation is inefficient. This conclusion is robust against the use of different alpha factor values, and/or different warm gas tracers (H_2 vs. H_2 plus CO): with the CO-probed gas mass being at least 40 times lower at 400K than at 25K, the total warm-to-cold mass ratio is always lower in the ambient gas than in the entrained gas. Heating of the molecular gas could facilitate the detection of new outflows in distant galaxies by enhancing their emission in intermediate rotational number CO lines., Comment: A&A, in press
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- 2014
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22. Galaxy size trends as a consequence of cosmology
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Stringer, M. J., Shankar, F., Novak, G. S., Huertas-Company, M., Combes, F., and Moster, B. P.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We show that recently documented trends in galaxy sizes with mass and redshift can be understood in terms of the influence of underlying cosmic evolution; a holistic view which is complimentary to interpretations involving the accumulation of discreet evolutionary processes acting on individual objects. Using standard cosmology theory, supported with results from the Millennium simulations, we derive expected size trends for collapsed cosmic structures, emphasising the important distinction between these trends and the assembly paths of individual regions. We then argue that the observed variation in the stellar mass content of these structures can be understood to first order in terms of natural limitations of cooling and feedback. But whilst these relative masses vary by orders of magnitude, galaxy and host radii have been found to correlate linearly. We explain how these two aspects will lead to galaxy sizes that closely follow observed trends and their evolution, comparing directly with the COSMOS and SDSS surveys. Thus we conclude that the observed minimum radius for galaxies, the evolving trend in size as a function of mass for intermediate systems, and the observed increase in the sizes of massive galaxies, may all be considered an emergent consequence of the cosmic expansion., Comment: 14 pages, 13 figures. Accepted by MNRAS
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- 2013
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23. Radiative Transfer and Radiative driving of Outflows in AGN and Starbursts
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Novak, G. S., Ostriker, J. P., and Ciotti, L.
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Astrophysics - Astrophysics of Galaxies - Abstract
To facilitate the study of black hole fueling, star formation, and feedback in galaxies, we outline a method for treating the radial forces on interstellar gas due to absorption of photons by dust grains. The method gives the correct behavior in all of the relevant limits (dominated by the central point source; dominated by the distributed isotropic source; optically thin; optically thick to UV/optical; optically thick to IR) and reasonably interpolates between the limits when necessary. The method is explicitly energy conserving so that UV/optical photons that are absorbed are not lost, but are rather redistributed to the IR where they may scatter out of the galaxy. We implement the radiative transfer algorithm in a two-dimensional hydrodynamical code designed to study feedback processes in the context of early-type galaxies. We find that the dynamics and final state of simulations are measurably but only moderately affected by radiative forces on dust, even when assumptions about the dust-to-gas ratio are varied from zero to a value appropriate for the Milky Way. In simulations with high gas densities designed to mimic ULIRGs with a star formation rate of several hundred solar masses per year, dust makes a more substantial contribution to the dynamics and outcome of the simulation. We find that, despite the large opacity of dust to UV radiation, the momentum input to the flow from radiation very rarely exceeds L/c due to two factors: the low opacity of dust to the re-radiated IR and the tendency for dust to be destroyed by sputtering in hot gas environments. We also develop a simplification of our radiative transfer algorithm that respects the essential physics but is much easier to implement and requires a fraction of the computational cost., Comment: 25 pages, 17 figures, submitted to MNRAS
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- 2012
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24. Magnetic Field Structure around Low-Mass Class 0 Protostars: B335, L1527 and IC348-SMM2
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Davidson, J. A., Novak, G., Matthews, T. G., Matthews, B., Goldsmith, P. F., Chapman, N., Volgenau, N. H., Vaillancourt, J. E., and Attard, M.
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Astrophysics - Astrophysics of Galaxies - Abstract
We report new 350 micron polarization observations of the thermal dust emission from the cores surrounding the low-mass, Class 0 YSOs L1527, IC348-SMM2 and B335. We have inferred magnetic field directions from these observations, and have used them together with results in the literature to determine whether magnetically regulated core-collapse and star-formation models are consistent with the observations. These models predict a pseudo-disk with its symmetry axis aligned with the core magnetic field. The models also predict a magnetic field pinch structure on a scale less than or comparable to the infall radii for these sources. In addition, if the core magnetic field aligns (or nearly aligns) the core rotation axis with the magnetic field before core collapse, then the models predict the alignment (or near alignment) of the overall pinch field structure with the bipolar outflows in these sources. We show that if one includes the distorting effects of bipolar outflows on magnetic fields, then in general the observational results for L1527 and IC348-SMM2 are consistent with these magnetically regulated models. We can say the same for B335 only if we assume the distorting effects of the bipolar outflow on the magnetic fields within the B335 core are much greater than for L1527 and IC348-SMM2. We show that the energy densities of the outflows in all three sources are large enough to distort the magnetic fields predicted by magnetically regulated models., Comment: Accepted for publication in The Astrophysical Journal
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- 2011
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25. A Constraint on the Organization of the Galactic Center Magnetic Field Using Faraday Rotation
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Law, C. J., Brentjens, M. A., and Novak, G.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present new 6 and 20 cm Very Large Array (VLA) observations of polarized continuum emission of roughly 0.5 square degrees of the Galactic center (GC) region. The 6 cm observations detect diffuse linearly-polarized emission throughout the region with a brightness of roughly 1 mJy per 15"x10" beam. The Faraday rotation measure (RM) toward this polarized emission has structure on degree size scales and ranges from roughly +330 rad/m2 east of the dynamical center (Sgr A) to -880 rad/m2 west of the dynamical center. This RM structure is also seen toward several nonthermal radio filaments, which implies that they have a similar magnetic field orientation and constrains models for their origin. Modeling shows that the RM and its change with Galactic longitude are best explained by the high electron density and strong magnetic field of the GC region. Considering the emissivity of the GC plasma shows that while the absolute RM values are indirect measures of the GC magnetic field, the RM longitude structure directly traces the magnetic field in the central kiloparsec of the Galaxy. Combining this result with previous work reveals a larger RM structure covering the central ~2 degrees of the Galaxy. This RM structure is similar to that proposed by Novak and coworkers, but is shifted roughly 50 pc west of the dynamical center of the Galaxy. If this RM structure originates in the GC region, it shows that the GC magnetic field is organized on ~300 pc size scales. The pattern is consistent with a predominantly poloidal field geometry, pointing from south to north, that is perturbed by the motion of gas in the Galactic disk., Comment: Accepted to ApJ. emulateapj style, 14 pages, 15 figures
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- 2011
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26. Feedback from Central Black Holes in Elliptical Galaxies: Two-dimensional Models Compared to One-dimensional Models
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Novak, G. S., Ostriker, J. P., and Ciotti, L.
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Astrophysics - Astrophysics of Galaxies - Abstract
We extend the black hole (BH) feedback models of Ciotti, Ostriker, and Proga to two dimensions. In this paper, we focus on identifying the differences between the one-dimensional and two-dimensional hydrodynamical simulations. We examine a normal, isolated $L_*$ galaxy subject to the cooling flow instability of gas in the inner regions. Allowance is made for subsequent star formation, Type Ia and Type II supernovae, radiation pressure, and inflow to the central BH from mildly rotating galactic gas which is being replenished as a normal consequence of stellar evolution. The central BH accretes some of the infalling gas and expels a conical wind with mass, momentum, and energy flux derived from both observational and theoretical studies. The galaxy is assumed to have low specific angular momentum in analogy with the existing one-dimensional case in order to isolate the effect of dimensionality. The code then tracks the interaction of the outflowing radiation and winds with the galactic gas and their effects on regulating the accretion. After matching physical modeling to the extent possible between the one-dimensional and two-dimensional treatments, we find essentially similar results in terms of BH growth and duty cycle (fraction of the time above a given fraction of the Eddington luminosity). In the two-dimensional calculations, the cool shells forming at 0.1--1 kpc from the center are Rayleigh--Taylor unstable to fragmentation, leading to a somewhat higher accretion rate, less effective feedback, and a more irregular pattern of bursting compared to the one-dimensional case., Comment: 15 pages, 10 figures, ApJ 237:26. Updated to match published version
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- 2010
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27. Polarimetry of DG Tau at 350 microns
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Krejny, M., Matthews, T., Novak, G., Cho, J., Li, H., Shinnaga, H., and Vaillancourt, J. E.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present the first 350 micron polarization measurement for the disk of the T Tauri star (TTS) DG Tau. The data were obtained using the SHARP polarimeter at the Caltech Submillimeter Observatory. We did not detect polarization but we provide constraints on the normalized Stokes parameters q and u. We derive information about the polarization spectrum by comparing our 350 micron result with an 850 micron polarization detection previously published for this source. This empirical information concerning the polarization spectrum disagrees with the predictions of a recent model for TTS disk polarization. We conclude, however, that adding more mass to the model disk would probably result in model polarization spectra that agree much better with the 350 and 850 micron polarimetric observations. We suggest that multiwavelength polarimetry of TTS disk emission may provide a promising method for probing the opacity of TTS disks., Comment: 20 pages, 2 figures, one table
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- 2009
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28. The Balloon-borne Large-Aperture Submillimeter Telescope for Polarization: BLAST-pol
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Marsden, G., Ade, P. A. R., Benton, S., Bock, J. J., Chapin, E. L., Chung, J., Devlin, M. J., Dicker, S., Fissel, L., Griffin, M., Gundersen, J. O., Halpern, M., Hargrave, P. C., Hughes, D. H., Klein, J., Korotkov, A., MacTavish, C. J., Martin, P. G., Martin, T. G., Matthews, T. G., Mauskopf, P., Moncelsi, L., Netterfield, C. B., Novak, G., Pascale, E., Olmi, L., Patanchon, G., Rex, M., Savini, G., Scott, D., Semisch, C., Thomas, N., Truch, M. D. P., Tucker, C., Tucker, G. S., Viero, M. P., Ward-Thompson, D., and Wiebe, D. V.
- Subjects
Astrophysics - Abstract
The Balloon-borne Large Aperture Submillimeter Telescope (BLAST) is a sub-orbital experiment designed to study the process of star formation in local galaxies (including the Milky Way) and in galaxies at cosmological distances. Using a 2-m Cassegrain telescope, BLAST images the sky onto a focal plane, which consists of 270 bolometric detectors split between three arrays, observing simultaneously in 30% wide bands, centered at 250, 350, and 500 microns. The diffraction-limited optical system provides a resolution of 30" at 250 microns. The pointing system enables raster-like scans with a positional accuracy of ~30", reconstructed to better than 5" rms in post-flight analysis. BLAST had two successful flights, from the Arctic in 2005, and from Antarctica in 2006, which provided the first high-resolution and large-area (~0.8-200 deg^2) submillimeter surveys at these wavelengths. As a pathfinder for the SPIRE instrument on Herschel, BLAST shares with the ESA satellite similar focal plane technology and scientific motivation. A third flight in 2009 will see the instrument modified to be polarization-sensitive (BLAST-Pol). With its unprecedented mapping speed and resolution, BLAST-Pol will provide insights into Galactic star-forming nurseries, and give the necessary link between the larger, coarse resolution surveys and the narrow, resolved observations of star-forming structures from space and ground based instruments being commissioned in the next 5 years., Comment: SPIE Conference Proceedings
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- 2008
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29. New Results on the Submillimeter Polarization Spectrum of the Orion Molecular Cloud
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Vaillancourt, J. E., Dowell, C. D., Hildebrand, R. H., Kirby, L., Krejny, M. M., Li, H., Novak, G., Houde, M., Shinnaga, H., and Attard, M.
- Subjects
Astrophysics - Abstract
We have used the SHARP polarimeter at the Caltech Submillimeter Observatory to map the polarization at wavelengths of 350 and 450 micron in a ~2 x 3 arcmin region of the Orion Molecular Cloud. The map covers the brightest region of the OMC-1 ridge including the Kleinmann-Low (KL) nebula and the submillimeter source Orion-south. The ratio of 450-to-350 micron polarization is ~ 1.3 +/- 0.3 in the outer parts of the cloud and drops by a factor of 2 towards KL. The outer cloud ratio is consistent with measurements in other clouds at similar wavelengths and confirms previous measurements placing the minimum of the polarization ratio in dusty molecular clouds at a wavelength ~ 350 micron., Comment: 7 pages, 6 figures, submitted to ApJ Lett
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- 2008
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30. Far-infrared polarimetry from the Stratospheric Observatory for Infrared Astronomy
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Vaillancourt, J. E., Chuss, D. T., Crutcher, R. M., Dotson, J. L., Dowell, C. D., Harper, D. A., Hildebrand, R. H., Jones, T. J., Lazarian, A., Novak, G., and Werner, M. W.
- Subjects
Astrophysics - Abstract
Multi-wavelength imaging polarimetry at far-infrared wavelengths has proven to be an excellent tool for studying the physical properties of dust, molecular clouds, and magnetic fields in the interstellar medium. Although these wavelengths are only observable from airborne or space-based platforms, no first-generation instrument for the Stratospheric Observatory for Infrared Astronomy (SOFIA) is presently designed with polarimetric capabilities. We study several options for upgrading the High-resolution Airborne Wideband Camera (HAWC) to a sensitive FIR polarimeter. HAWC is a 12 x 32 pixel bolometer camera designed to cover the 53 - 215 micron spectral range in 4 colors, all at diffraction-limited resolution (5 - 21 arcsec). Upgrade options include: (1) an external set of optics which modulates the polarization state of the incoming radiation before entering the cryostat window; (2) internal polarizing optics; and (3) a replacement of the current detector array with two state-of-the-art superconducting bolometer arrays, an upgrade of the HAWC camera as well as polarimeter. We discuss a range of science studies which will be possible with these upgrades including magnetic fields in star-forming regions and galaxies and the wavelength-dependence of polarization., Comment: 12 pages, 5 figures
- Published
- 2007
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31. Dispersion of Observed Position Angles of Submillimeter Polarization in Molecular Clouds
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Novak, G., Dotson, J. L., and Li, H.
- Subjects
Astrophysics - Abstract
One can estimate the characteristic magnetic field strength in GMCs by comparing submillimeter polarimetric observations of these sources with simulated polarization maps developed using a range of different values for the assumed field strength. The point of comparison is the degree of order in the distribution of polarization position angles. In a recent paper by H. Li and collaborators, such a comparison was carried out using SPARO observations of two GMCs, and employing simulations by E. Ostriker and collaborators. Here we reexamine this same question, using the same data set and the same simulations, but using an approach that differs in several respects. The most important difference is that we incorporate new, higher angular resolution observations for one of the clouds, obtained using the Hertz polarimeter. We conclude that the agreement between observations and simulations is best when the total magnetic energy (including both uniform and fluctuating field components) is at least as large as the turbulent kinetic energy., Comment: revised, accepted version; to appear in The Astrophysical Journal; 20 pages, 2 figures, 2 tables
- Published
- 2007
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32. Design and Initial Performance of SHARP, a Polarimeter for the SHARC-II Camera at the Caltech Submillimeter Observatory
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Li, H., Dowell, C. D., Kirby, L., Novak, G., and Vaillancourt, J. E.
- Subjects
Astrophysics - Abstract
We have developed a fore-optics module that converts the SHARC-II camera at the Caltech Submillimeter Observatory into a sensitive imaging polarimeter at wavelengths of 350 and 450 microns. We refer to this module as "SHARP". SHARP splits the incident radiation into two orthogonally polarized beams that are then re-imaged onto opposite ends of the 32 x 12 pixel detector array in SHARC-II. A rotating half-wave plate is used just upstream from the polarization-splitting optics. The effect of SHARP is to convert SHARC-II into a dual-beam 12 x 12 pixel polarimeter. A novel feature of SHARP's design is the use of a crossed grid in a submillimeter polarimeter. Here we describe the detailed optical design of SHARP and present results of tests carried out during our first few observing runs. At 350 microns, the beam size (9 arcseconds), throughput (75%), and instrumental polarization (< 1%) are all very close to our design goals., Comment: submitted to Applied Optics
- Published
- 2007
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33. Radius Dependent Luminosity Evolution of Blue Galaxies in GOODS-N
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Melbourne, J., Phillips, A. C., Harker, J., Novak, G., Koo, D. C., and Faber, S. M.
- Subjects
Astrophysics - Abstract
We examine the radius-luminosity (R-L) relation for blue galaxies in the Team Keck Redshift Survey (TKRS) of GOODS-N. We compare with a volume-limited, Sloan Digital Sky Survey sample and find that the R-L relation has evolved to lower surface brightness since z=1. Based on the detection limits of GOODS this can not be explained by incompleteness in low surface-brightness galaxies. Number density arguments rule out a pure radius evolution. It can be explained by a radius dependent decline in B-band luminosity with time. Assuming a linear shift in M_B with z, we use a maximum likelihood method to quantify the evolution. Under these assumptions, large (R_{1/2} > 5 kpc), and intermediate sized (3 < R_{1/2} < 5 kpc) galaxies, have experienced Delta M_B =1.53 (-0.10,+0.13) and 1.65 (-0.18, +0.08) magnitudes of dimming since z=1. A simple exponential decline in star formation with an e-folding time of 3 Gyr can result in this amount of dimming. Meanwhile, small galaxies, or some subset thereof, have experienced more evolution, 2.55 (+/- 0.38) magnitudes. This factor of ten decline in luminosity can be explained by sub-samples of starbursting dwarf systems that fade rapidly, coupled with a decline in burst strength or frequency. Samples of bursting, luminous, blue, compact galaxies at intermediate redshifts have been identified by various previous studies. If there has been some growth in galaxy size with time, these measurements are upper limits on luminosity fading., Comment: 34 Total pages, 15 Written pages, 19 pages of Data Table, 13 Figures, accepted for publication in ApJ
- Published
- 2006
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34. Results of SPARO 2003: Mapping Magnetic Fields in Giant Molecular Clouds
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Li, H., Griffin, G. S., Krejny, M., Novak, G., Loewenstein, R. F., Newcomb, M. G., Calisse, P. G., and Chuss, D. T.
- Subjects
Astrophysics - Abstract
We present results from the Austral Winter 2003 observing campaign of SPARO, a 450 micron polarimeter used with a two-meter telescope at South Pole. We mapped large-scale magnetic fields in four Giant Molecular Clouds (GMCs) in the Galactic disk: NGC 6334, the Carina Nebula, G333.6-0.2 and G331.5-0.1. We find a statistically significant correlation of the inferred field directions with the orientation of the Galactic plane. Specifically, three of the four GMCs (NGC 6334 is the exception) have mean field directions that are within 15 degrees of the plane. The simplest interpretation is that the field direction tends to be preserved during the process of GMC formation. We have also carried out an analysis of published optical polarimetry data. For the closest of the SPARO GMCs, NGC 6334, we can compare the field direction in the cloud as measured by SPARO with the field direction in a larger region surrounding the cloud, as determined from optical polarimetry. For purposes of comparison, we also use optical polarimetry to determine field directions for other regions of similar size and distance. Overall, the results from this optical polarimetry analysis are consistent with our suggestion that field direction tends to be preserved during GMC formation. Finally, we compare the disorder in our magnetic field maps with the disorder seen in magnetic field maps derived from MHD turbulence simulations. We conclude from these comparisons that the magnetic energy density in our clouds is comparable to the turbulent energy density., Comment: Submitted to Astrophys. J. (one color figure)
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- 2006
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35. Lost & Found Dark Matter in Elliptical Galaxies
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Dekel, A., Stoehr, F., Mamon, G. A., Cox, T. J., Novak, G. S., and Primack, J. R.
- Subjects
Astrophysics - Abstract
There is strong evidence that the mass in the Universe is dominated by dark matter, which exerts gravitational attraction but whose exact nature is unknown. In particular, all galaxies are believed to be embedded in massive haloes of dark matter. This view has recently been challenged by surprisingly low random stellar velocities in the outskirts of ordinary elliptical galaxies, which were interpreted as indicating a lack of dark matter (Mendez et al. 2001; Romanowsky et al. 2003). Here we show that the low velocities are in fact compatible with galaxy formation in dark-matter haloes. Using numerical simulations of disc-galaxy mergers, we find that the stellar orbits in the outer regions of the resulting ellipticals are very elongated. These stars were torn by tidal forces from their original galaxies during the first close passage and put on outgoing trajectories. The elongated orbits, combined with the steeply falling density profile of the observed tracers, explain the observed low velocities even in the presence of large amounts of dark matter. Projection effects when viewing a triaxial elliptical can lead to even lower observed velocities along certain lines of sight., Comment: Letter to Nature, 13+15 pages, 2+11 figures, improved text, extended Supplementary Information added
- Published
- 2005
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36. First Results from SPARO: Evidence for Large-Scale Toroidal Magnetic Fields in the Galactic Center
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Novak, G., Chuss, D. T., Renbarger, T., Griffin, G. S., Newcomb, M. G., Peterson, J. B., Loewenstein, R. F., Pernic, D., and Dotson, J. L.
- Subjects
Astrophysics - Abstract
We have observed the linear polarization of 450 micron continuum emission from the Galactic center, using a new polarimetric detector system that is operated on a 2 m telescope at the South Pole. The resulting polarization map extends ~ 170 pc along the Galactic plane and ~ 30 pc in Galactic latitude, and thus covers a significant fraction of the central molecular zone. Our map shows that this region is permeated by large-scale toroidal magnetic fields. We consider our results together with radio observations that show evidence for poloidal fields in the Galactic center, and with Faraday rotation observations. We compare all of these observations with the predictions of a magnetodynamic model for the Galactic center that was proposed in order to explain the Galactic Center Radio Lobe as a magnetically driven gas outflow. We conclude that the observations are basically consistent with the model., Comment: 11 pages, 2 figures, 1 table, submitted to ApJ Lett
- Published
- 2001
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37. Anisotropy in the Cosmic Microwave Background at Degree Angular Scales: Python V Results
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Coble, K., Dragovan, M., Kovac, J., Halverson, N. W., Holzapfel, W. L., Knox, L., Dodelson, S., Ganga, K., Alvarez, D., Peterson, J. B., Griffin, G., Newcomb, M., Miller, K., Platt, S. R., and Novak, G.
- Subjects
Astrophysics - Abstract
Observations of the microwave sky using the Python telescope in its fifth season of operation at the Amundsen-Scott South Pole Station in Antarctica are presented. The system consists of a 0.75 m off-axis telescope instrumented with a HEMT amplifier-based radiometer having continuum sensitivity from 37-45 GHz in two frequency bands. With a 0.91 deg x 1.02 deg beam the instrument fully sampled 598 deg^2 of sky, including fields measured during the previous four seasons of Python observations. Interpreting the observed fluctuations as anisotropy in the cosmic microwave background, we place constraints on the angular power spectrum of fluctuations in eight multipole bands up to l ~ 260. The observed spectrum is consistent with both the COBE experiment and previous Python results. There is no significant contamination from known foregrounds. The results show a discernible rise in the angular power spectrum from large (l ~ 40) to small (l ~ 200) angular scales. The shape of the observed power spectrum is not a simple linear rise but has a sharply increasing slope starting at l ~ 150., Comment: 5 pages
- Published
- 1999
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38. Anisotropy of the Microwave Sky at 90 GHz: Results from Python II
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Ruhl, J. E., Dragovan, M., Platt, S. R., Kovac, J., and Novak, G.
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Astrophysics - Abstract
We report on additional observations of degree scale anisotropy at 90~GHz from the Amundsen-Scott South Pole Station in Antarctica. Observations during the first season with the Python instrument yielded a statistically significant sky signal; in this paper we report the confirmation of that signal with data taken in the second year, and on results from an interleaving set of fields., Comment: 10 pages, plus 2 figures. Postscript and uufiles versions available via anonymous ftp at ftp://astro.uchicago.edu/pub/astro/ruhl/pyII
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- 1995
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39. P702 Clinical and biomarker remission is maintained after switch from monthly dosed intravenous to subcutaneous maintenance treatment with vedolizumab in Inflammatory Bowel Disease
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Pintar, S, primary, Hanžel, J, additional, Smrekar, N, additional, Koželj, M, additional, Drobne, D, additional, Kurent, T, additional, Štabuc, B, additional, and Novak, G, additional
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- 2023
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40. In-flight performance of the BLAST-TNG Kinetic Inductance Detector arrays and Readout Electronics
- Author
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Sinclair, A, Gordon, S, Ade, P, Ashton, P, Cho, H, Coppi, G, Corso, A, Devlin, M, Dicker, S, Dober, B, Fissel, L, Galitzky, N, Gao, J, Groppi, C, Hilton, G, Hubmayr, J, Irwin, K, Klein, J, Li, D, Lourie, N, Lowe, I, Mani, H, Mauskopf, P, Mckenney, C, Nati, F, Novak, G, Pascale, E, Pisano, G, Soler, J, Tucker, C, Underhil, M, Vissers, M, Wheeler, C, Williams, P, Sinclair A., Gordon S. B., Ade P., Ashton P., Cho H. -M., Coppi G., Corso A., Devlin M., Dicker S., Dober B., Fissel L., Galitzky N., Gao J., Groppi C., Hilton G. C., Hubmayr J., Irwin K., Klein J., Li D., Lourie N., Lowe I., Mani H., Mauskopf P. D., McKenney C., Nati F., Novak G., Pascale E., Pisano G., Soler J., Tucker C., Underhil M., Vissers M., Wheeler C., Williams P., Sinclair, A, Gordon, S, Ade, P, Ashton, P, Cho, H, Coppi, G, Corso, A, Devlin, M, Dicker, S, Dober, B, Fissel, L, Galitzky, N, Gao, J, Groppi, C, Hilton, G, Hubmayr, J, Irwin, K, Klein, J, Li, D, Lourie, N, Lowe, I, Mani, H, Mauskopf, P, Mckenney, C, Nati, F, Novak, G, Pascale, E, Pisano, G, Soler, J, Tucker, C, Underhil, M, Vissers, M, Wheeler, C, Williams, P, Sinclair A., Gordon S. B., Ade P., Ashton P., Cho H. -M., Coppi G., Corso A., Devlin M., Dicker S., Dober B., Fissel L., Galitzky N., Gao J., Groppi C., Hilton G. C., Hubmayr J., Irwin K., Klein J., Li D., Lourie N., Lowe I., Mani H., Mauskopf P. D., McKenney C., Nati F., Novak G., Pascale E., Pisano G., Soler J., Tucker C., Underhil M., Vissers M., Wheeler C., and Williams P.
- Published
- 2020
41. Characterization, deployment, and in-flight performance of the BLAST-TNG cryogenic receiver
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Zmuidzinas J.,Gao J.-R., Lowe, I, Ade, P, Ashton, P, Austermann, J, Coppi, G, Cox, E, Devlin, M, Dober, B, Fanfani, V, Fissel, L, Galitzki, N, Gao, J, Gordon, S, Groppi, C, Hilton, G, Hubmayr, J, Klein, J, Li, D, Lourie, N, Mani, H, Mauskopf, P, Mckenney, C, Nati, F, Novak, G, Pisano, G, Romualdez, J, Soler, J, Sinclair, A, Tucker, C, Ullom, J, Vissers, M, Wheeler, C, Williams, P, Lowe I., Ade P. A. R., Ashton P. C., Austermann J. E., Coppi G., Cox E. G., Devlin M. J., Dober B. J., Fanfani V., Fissel L. M., Galitzki N., Gao J., Gordon S., Groppi C. E., Hilton G. C., Hubmayr J., Klein J., Li D., Lourie N. P., Mani H., Mauskopf P., McKenney C., Nati F., Novak G., Pisano G., Romualdez J., Soler J. D., Sinclair A., Tucker C., Ullom J., Vissers M., Wheeler C., Williams P. A., Zmuidzinas J.,Gao J.-R., Lowe, I, Ade, P, Ashton, P, Austermann, J, Coppi, G, Cox, E, Devlin, M, Dober, B, Fanfani, V, Fissel, L, Galitzki, N, Gao, J, Gordon, S, Groppi, C, Hilton, G, Hubmayr, J, Klein, J, Li, D, Lourie, N, Mani, H, Mauskopf, P, Mckenney, C, Nati, F, Novak, G, Pisano, G, Romualdez, J, Soler, J, Sinclair, A, Tucker, C, Ullom, J, Vissers, M, Wheeler, C, Williams, P, Lowe I., Ade P. A. R., Ashton P. C., Austermann J. E., Coppi G., Cox E. G., Devlin M. J., Dober B. J., Fanfani V., Fissel L. M., Galitzki N., Gao J., Gordon S., Groppi C. E., Hilton G. C., Hubmayr J., Klein J., Li D., Lourie N. P., Mani H., Mauskopf P., McKenney C., Nati F., Novak G., Pisano G., Romualdez J., Soler J. D., Sinclair A., Tucker C., Ullom J., Vissers M., Wheeler C., and Williams P. A.
- Abstract
The Next Generation Balloon-borne Large Aperture Submillimeter Telescope (BLAST-TNG) is a submillimeter polarimeter designed to map interstellar dust and galactic foregrounds at 250, 350, and 500 microns during a 24-day Antarctic flight. The BLAST-TNG detector arrays are comprised of 918, 469, and 272 MKID pixels, respectively. The pixels are formed from two orthogonally oriented, crossed, linear-polarization sensitive MKID antennae. The arrays are cooled to sub 300 mK temperatures and stabilized via a closed cycle 3He sorption fridge in combination with a 4He vacuum pot. The detectors are read out through a combination of the second-generation Reconfigurable Open Architecture Computing Hardware (ROACH2) and custom RF electronics designed for BLAST-TNG. The firmware and software designed to readout and characterize these detectors was built from scratch by the BLAST team around these detectors, and has been adapted for use by other MKID instruments such as TolTEC and OLIMPO.1 We present an overview of these systems as well as in-depth methodology of the ground-based characterization and the measured in-flight performance.
- Published
- 2020
42. Natural History and Risk Stratification of Recurrent Crohn's Disease After Ileocolonic Resection: A Multicenter Retrospective Cohort Study
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Joustra, V., Duijvestein, M., Mookhoek, A., Bemelman, W., Buskens, C., Koželj, M., Novak, G., Hindryckx, P., Mostafavi, N., d'Haens, G., Joustra, V., Duijvestein, M., Mookhoek, A., Bemelman, W., Buskens, C., Koželj, M., Novak, G., Hindryckx, P., Mostafavi, N., and d'Haens, G.
- Abstract
Item does not contain fulltext, BACKGROUND: Prediction of endoscopic postoperative recurrence (POR) and prophylactic treatment based on clinical risk profile have thus far been inconclusive. This study aimed to examine the association between clinical risk profile and the development of endoscopic POR in a Crohn's disease population without postoperative treatment and to identify individual risk factors of endoscopic POR. METHODS: Medical records of 142 patients with Crohn's disease during follow-up after ileocecal or ileocolonic resection without prophylactic treatment at 3 referral centers were reviewed. Endoscopic POR was defined as a modified Rutgeerts score ≥i2b. Clinical risk profiles were distilled from current guidelines. Both uni- and multivariate logistic regression analysis were used to assess the relationship between risk profiles and endoscopic POR. RESULTS: Endoscopic POR was observed in 68 out of 142 (47.9%) patients. Active smoking postsurgery (odds ratio [OR], 3.01; 95% confidence interval [CI], 1.24-7.34; P = 0.02), a Montreal classification of A3 (OR, 3.05; 95% CI, 1.07-8.69; P = 0.04), and previous bowel resections (OR, 2.58; 95% CI, 1.07-6.22; P = 0.03) were significantly associated with endoscopic POR. No significant association was observed between endoscopic POR and any guideline defined as a high-/low-risk profile. However, patients with a combination of any 3 or more European Crohns & Colitis Organisation- (OR, 4.87; 95% CI, 1.30-18.29; P = 0.02) or British Society of Gastroenterology-defined (OR 3.16; 95% CI, 1.05-9.49; P = 0.04) risk factors showed increased odds of developing endoscopic POR. CONCLUSIONS: Our results suggest that patients with a combination of any 3 or more European Crohns & Colitis Organisation- or British Society of Gastroenterology-defined risk factors would probably benefit from immediate prophylactic treatment.
- Published
- 2022
43. Review article: dose optimisation of infliximab for acute severe ulcerative colitis
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Hindryckx, P., Novak, G., Vande Casteele, N., Laukens, D., Parker, C., Shackelton, L. M, Narula, N., Khanna, R., Dulai, P., Levesque, B. G, Sandborn, W. J, DʼHaens, G., Feagan, B. G., and Jairath, V.
- Published
- 2017
- Full Text
- View/download PDF
44. Blood Derived Amyloid Biomarkers for Alzheimer's Disease Prevention
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Udeh-Momoh, C, Zheng, B, Sandebring-Matton, A, Novak, G, Kivipelto, M, Jönsson, L, and Middleton, L
- Abstract
BACKGROUND: Reliable, widely accessible and affordable biomarkers for predicting Alzheimer's disease (AD) brain pathology status are a necessity to aid development of prevention strategies in cognitively healthy at-risk older adults, at the right timepoint. Measurements of the key neuropathological hallmark beta-amyloid (Aβ) by PET neuroimaging or cerebrospinal fluid measures reflect its accumulation in the brain, yet recent methodological advancements now enable blood-based measures reflecting cerebral amyloid burden. OBJECTIVES: The current study validated the capacity of plasma Aβ42/Aβ40 measured using six different assays to predict amyloid positivity in a subgroup of cognitively unimpaired (CU) participants in the ADNI study and assessed its ability to discriminate CU from AD cases. We also explored economic viability of using two different plasma amyloid assays for pre-screening in AD prevention trials and as routine clinical diagnostic tool, versus amyloid PET alone. DESIGN: A cross-sectional analysis of plasma and brain amyloid data, including comparative cost analysis of the plasma biomarkers in relation to brain amyloid PET. SETTING: Alzheimer's Disease Neuroimaging Initiative (ADNI). PARTICIPANTS: ADNI participants consisting of 115 CU, mild cognitive impairment and AD cases who had plasma Aβ42/Aβ40 measured with six platforms. MEASUREMENTS: Plasma Aβ42/Aβ40 was measured via six different platforms: three immunoassays (Roche, Quanterix and ADx Neurosciences) and three mass spectrometry (MS) based assays (WashU, Shimadzu and Gothenburg). Aβ-PET imaging was conducted within three months of plasma sampling using [18F]florbetapir. RESULTS: There was a weak to moderate correlation of plasma Aβ42/Aβ40 ratio between platforms. The MS-based WashU test had the highest capacity to discriminate between CU and AD (area under the curve, AUC = 0.734, 95% CI: 0.613-0.854; P = 0.008). Within the CU group, the WashU plasma amyloid test had the best discriminative capacity to distinguish Aβ+ from Aβ- (AUC = 0.753, 95% CI: 0.601-0.905; P = 0.003) closely followed by the immunoassay from Roche (AUC = 0.737, 95% CI: 0.597-0.877; P = 0.006). The exploratory economic analyses showed that the use of Roche or WashU plasma amyloid assay as a pre-screening tool prior to Aβ-PET scans for clinical trial recruitment significantly reduced total screening cost (saving up to $5882 per recruited patient) expected in an AD prevention trial. CONCLUSIONS: With few available treatment strategies, dementia prevention is a global priority. CU individuals at risk for AD are the target population for dementia prevention but have been poorly studied. Our findings confirming diagnostic value of ultrasensitive immunoassays and high-performance immunoprecipitation coupled with MS for measurement of plasma Aβ42/Aβ40 to detect PET amyloid positivity in CU participants allude to potential clinical utility of this biomarker. Plasma Aβ42/Aβ40 could be optimal for pre-selecting at-risk candidates for more invasive and expensive investigations across AD prevention clinical trials and clinical care for a rapidly ageing population.
- Published
- 2021
45. Failure Analysis of a Corroded Threaded Fitting in an Ammonia Refrigeration System
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Sanders, S. A., Stevenson, M. E., Novak, G. J., and Pape, R.
- Published
- 2014
- Full Text
- View/download PDF
46. Early Results from SPARO: Instrument Characterization and Polarimetry of NGC 6334
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Renbarger, T., Chuss, D. T., Dotson, J. L., Griffin, G. S., Hanna, J. L., Loewenstein, R. F., Malhotra, P. S., Marshall, J. L., Novak, G., and Pernic, R. J.
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- 2004
- Full Text
- View/download PDF
47. In-flight performance of the BLAST-TNG Kinetic Inductance Detector arrays and Readout Electronics
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Sinclair A., Gordon S. B., Ade P., Ashton P., Cho H. -M., Coppi G., Corso A., Devlin M., Dicker S., Dober B., Fissel L., Galitzky N., Gao J., Groppi C., Hilton G. C., Hubmayr J., Irwin K., Klein J., Li D., Lourie N., Lowe I., Mani H., Mauskopf P. D., McKenney C., Nati F., Novak G., Pascale E., Pisano G., Soler J., Tucker C., Underhil M., Vissers M., Wheeler C., Williams P., Sinclair, A, Gordon, S, Ade, P, Ashton, P, Cho, H, Coppi, G, Corso, A, Devlin, M, Dicker, S, Dober, B, Fissel, L, Galitzky, N, Gao, J, Groppi, C, Hilton, G, Hubmayr, J, Irwin, K, Klein, J, Li, D, Lourie, N, Lowe, I, Mani, H, Mauskopf, P, Mckenney, C, Nati, F, Novak, G, Pascale, E, Pisano, G, Soler, J, Tucker, C, Underhil, M, Vissers, M, Wheeler, C, and Williams, P
- Subjects
kinetic inductance detectors, infrared astronomy, balloon borne telescopes - Published
- 2020
48. A Primer on Far‐Infrared Polarimetry
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Hildebrand, R. H., Davidson, J. A., Dotson, J. L., Dowell, C. D., Novak, G., and Vaillancourt, J. E.
- Published
- 2000
- Full Text
- View/download PDF
49. The Link Between Magnetic Fields and Cloud/Star Formation
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Li, H.-B., primary, Goodman, A., additional, Sridharan, T. K., additional, Houde, M., additional, Li, Z.-Y., additional, Novak, G., additional, and Tang, K. S., additional
- Published
- 2014
- Full Text
- View/download PDF
50. Strain Gauge Pack in Process Measurement System for the Collider Quadrupole, Design and Technology Transfer
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Zeigler, Richard E., Bein, D., Brooks, L., Garza, M., Rodgers, B., Novak, G., and Hale, Phyllis, editor
- Published
- 1994
- Full Text
- View/download PDF
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