Search

Your search keyword '"Nourani M"' showing total 374 results
Start Over Author "Nourani M"

Refine your results

more »

more »

more »

more »
374 results on '"Nourani M"'

1. Rapid Diagnosis of acute kidney injury (AKI) associated with cardiac surgery, using the liver type fatty acid binding protein (L-FABP) biomarker

Author

Mirbagheri M, Taghipour H R, Farhadi N, Mirbagheri L, Imani Foladi AA, and Nourani M R

Subjects
acute kidney injury, liver type fatty acid binding protein, cardiac surgery, Medicine
Abstract

Abstract Background and objectives: cardiac surgery is often associated with acute kidney injury (AKI). Nowadays, AKI is typically diagnosed by an increase in serum creatinine, which is a delayed and unreliable biomarker. Recent studies recommended using the liver type fatty acid binding protein (L-FABP) as an early biomarker. Material and Methods: The urine samples of 18 adult patients undergoing cardiac surgery were collected in different times before (2, 4,8,24 hour) and after cardiac surgery for detection of L-FABP by Elisa. Results: The results from ELISA test show that the increasing amount of L-FABP in urine samples of 4 patients is a diagnostic indicator for AKI. The mean concentration of L-FABP has increased up to 17 times at 8 hours after cardiac surgery compared to before surgery. Conclusion: according to our findings, we speculated that the urinary L-FABP can be a reliable and rapid biomarker for diagnosis of acute kidney injury. Key words: Acute Kidney Injury, Liver type Fatty Acid Binding Protein, Cardiac surgery

Published
2012

2. Effect of Sodium Cyanide-induced Tissue Hypoxia on Reproductive Capability of Male Mice and the Protective Effect of Ethyl Pyruvate

Author

Nourani, M. R, Kalantari Hesari, A, Shahrooz, R, and Asadi, M. R

Subjects
Male, ethyl pyruvate, cyanide, tissue hypoxia, mice, Reproduction, Veterinary medicine, reproduction potency, Sodium Cyanide, SF600-1100, Animals, Original Article, Hypoxia, Pyruvates, sodium
Abstract

The present study aimed to assess the effect of tissue hypoxia induced by sodium cyanide (NaCN) on male mice fertility and the protective role of ethyl pyruvate (EP). A number of 30 adult mice were assigned to three groups: 1) a control group, 2) a treatment group treated with 2 mg/kg of NaCN, and 3) a treatment group treated with 2 mg/kg of NaCN, along with 40 mg/kg EP (NaCN+EP). After 35 days, animals were anesthetized and serum, sperm, and tissue samples were taken. The results demonstrated a significant decrease in sperm quality, reproduction potency, and anti-oxidant potential, as well as an increase in lipid peroxidation in the NaCN group (pamp;lt;0.05). Moreover, the use of EP effectively restrained the disastrous effects of tissue hypoxia. It can be concluded that EP can moderate the complications resulting from tissue-hypoxia that is related to testes parameters.

Published
2021

11. Rat lung decellularization using chemical detergents for lung tissue engineering.

Author

Tebyanian, H., Karami, A., Motavallian, E., Samadikuchaksaraei, A., Arjmand, B., and Nourani, M. R.

Subjects
TISSUE engineering, SODIUM dodecyl sulfate, EXTRACELLULAR matrix proteins, TRITON X-100, LUNGS, LUNG diseases
Abstract

Although pulmonary diseases account for a large number of deaths in the world, most have no treatment other than transplantation. New therapeutic methods for lung treatment include lung tissue engineering and regenerative medicine. Lung decellularization has been used to produce an appropriate scaffold for recellularization and implantation. We investigated 3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS) with sodium dodecyl sulfate (SDS) and Triton X-100 detergents for effecting rat lung decellularization. We evaluated using conventional histology, immunofluorescence staining and SEM methods for removing nuclear material while leaving intact extracellular matrix proteins and three-dimensional architecture. We investigated different concentrations of CHAPS, SDS and Triton X-100 for different periods. We found that 2 mM CHAPS + 0/1% SDS for 48 h was the best among the treatments investigated. Our method can be used to produce an appropriate scaffold for recellularization by stem cells and for investigations ex vivo and in vivo. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

19. Synthesis and characterisation of highly interconnected porous poly(ε-caprolactone)-collagen scaffolds: a therapeutic design to facilitate tendon regeneration.

Author

Mozafari, M., Kargozar, S., de Santiago, G. T., Mohammadi, M. Rezaa, Milan, P. B., Foroutan Koudehi, M., Aghabarari, B., and Nourani, M. R.

Subjects
POLYCAPROLACTONE, COLLAGEN, CHEMICAL synthesis, TISSUE scaffolds, TENDONS, REGENERATION (Biology)
Abstract

Current tissue-engineering approaches require improved biomaterials to balance microstructural and mechanical design criteria. We investigated the effect of adding a naturally occurring polymer, collagen, to a synthetic scaffold made of poly(ε-caprolactone) (PCL). Hybrid PCL-collagen scaffolds with different collagen concentrations were prepared by solvent casting and freeze-drying techniques that included a subsequent chemical cross-linking. Scanning electron microscopy and Fourier transform infrared spectroscopy were used to characterise the microstructure and chemical interactions of the scaffolds. We found that the porous structure of the scaffolds can be tailored by changing the collagen concentration. In addition, we concluded that the scaffolds with 40% collagen exhibit remarkable enhancement in physicochemical and biological characteristics for tendon regeneration. The regenerated tissues were oriented longitudinally in relation to the long axis of the natural tendon, with a substantial number of blood vessels appearing deep within the scaffolds. [ABSTRACT FROM PUBLISHER]

Published
2018
Full Text
View/download PDF

20. Smad Molecules Expression Pattern in Human Bronchial Airway Induced by Sulfur Mustard

Author

Adelipour, M., Fooladi, A. A. I., Yazdani, S., Vahedi, E., Mostafa Ghanei, and Nourani, M. R.

Subjects
Sulfur Mustard, integumentary system, Reverse Transcriptase Polymerase Chain Reaction, Pulmonary Fibrosis, lcsh:R, lcsh:Medicine, Bronchi, Smad Proteins, Middle Aged, respiratory system, respiratory tract diseases, TGFβ, Mustard Gas, Airway Remodeling, Humans, Chemical Warfare Agents, Bronchial Airway, Smad
Abstract

Airway remodelling is characterized by the thickening and reorganization of the airways seen in mustard lung patients. Mustard lung is the general description for the chronic obstructive pulmonary disease induced by sulfur mustard(SM). Pulmonary disease was diagnosed as the most important disorder in individuals that had been exposed to sulfur mustard. Sulfur mustard is a chemical warfare agent developed during Wars. Iraqi forces frequently used it against Iranian during Iran –Iraq in the 1980–1988. Peribronchial fibrosis result from airway remodeling that include excess of collagen of extracellular matrix deposition in the airway wall. Some of Smads families in association with TGF-β are involved in airway remodeling due to lung fibrosis. In the present study we compared the mRNA expression of Smad2, Smad3, and Smad4 and Smad7 genes in airway wall biopsies of chemical-injured patients with non-injured patients as control. We used airway wall biopsies of ten unexposed patients and fifteen SM-induced patients. Smads expression was evaluated by RT-PCR followed by bands densitometry. Expression levels of Smad3 and Smad4 in SM exposed patients were upregulated but Smad2 and Smad7 was not significantly altered. Our results revealed that Smad3, and 4 may be involved in airway remodeling process in SM induced patients by activation of TGF-β. Smad pathway is the most represented signaling mechanism for airway remodeling and peribronchial fibrosis. The complex of Smads in the nucleus affects a series of genes that results in peribronchial fibrosis in SM- induced patients.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results