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10. High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor

Author

Auf, Gregor, primary, Jabouille, Arnaud, additional, Delugin, Maylis, additional, Guérit, Sylvaine, additional, Pineau, Raphael, additional, North, Sophie, additional, Platonova, Natalia, additional, Maitre, Marlène, additional, Favereaux, Alexandre, additional, Vajkoczy, Peter, additional, Seno, Masaharu, additional, Bikfalvi, Andreas, additional, Minchenko, Dmitri, additional, Minchenko, Oleksandr, additional, and Moenner, Michel, additional

Published
2013
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18. Study Trip to Yorkshire, 24-26 April 2015.

Author

MONAGHAN SMITH, KERRY, DAVIS, DIANA, LAMBERT, CATHY, DE WIT, ADA, CROSSLEY, BRIAN, NORTH, SOPHIE, and KARCZEWSKI-SLOWIKOWSKI, JANUSZ

Subjects
COUNTRY homes, EIGHTEENTH century, HISTORY
Abstract

The article evaluates the architectural design of the Yorkshire home of Sir Reginald and Lady Sheffield which was built in the 1750s by architect Thomas Atkinson and the eighteenth-century country house Newby Hall in Yorkshire, England.

Published
2016

22. Library language: words and their definitions.

Author

Carver, Kirsty, Introwicz, Maria, Mottram, Susan, and North, Sophie

Abstract

The article discusses the process of the University of Bradford for producing a web page with a glossary which developed into the booklet "Library Language: Words and Their Definitions." It states that the University followed the guidelines of the Society of College, National and University Libraries to develop the web page. It states that after creating webpage they started the compilation of the glossary which they send to University's staff for comments. It also offers information on processes like editing, development of library language and collection of feedback.

Published
2012

23. Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferation.

Author

Bianco S, Lanvin O, Tribollet V, Macari C, North S, and Vanacker JM

Subjects
Animals, Cell Cycle drug effects, Cell Line, Tumor, Down-Regulation, Gene Expression Regulation, Neoplastic drug effects, Humans, Mice, Neoplasms genetics, Neoplasms physiopathology, Nitriles pharmacology, Receptors, Estrogen genetics, Thiazoles pharmacology, ERRalpha Estrogen-Related Receptor, Cell Proliferation drug effects, Neoplasms metabolism, Receptors, Estrogen metabolism
Abstract

High expression of the estrogen receptor-related receptor (ERR)-alpha in human tumors is correlated to a poor prognosis, suggesting an involvement of the receptor in cell proliferation. In this study, we show that a synthetic compound (XCT790) that modulates the activity of ERRalpha reduces the proliferation of various cell lines and blocks the G(1)/S transition of the cell cycle in an ERRalpha-dependent manner. XCT790 induces, in a p53-independent manner, the expression of the cell cycle inhibitor p21(waf/cip)(1) at the protein, mRNA, and promoter level, leading to an accumulation of hypophosphorylated Rb. Finally, XCT790 reduces cell tumorigenicity in Nude mice.

Published
2009
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24. DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

Author

Courtois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U, Oren M, and Hainaut P

Subjects
Animals, Codon, DNA Damage, Female, Humans, Mice, Protein Isoforms, Proto-Oncogene Proteins metabolism, Proto-Oncogene Proteins c-mdm2, S Phase, Transcriptional Activation, Tumor Suppressor Protein p53 isolation & purification, Tumor Suppressor Protein p53 physiology, Breast Neoplasms chemistry, Nuclear Proteins, Tumor Suppressor Protein p53 chemistry
Abstract

The tumor suppressor protein p53 is ubiquitously expressed as a major isoform of 53 kD, but several forms of lower molecular weight have been observed. Here, we describe a new isoform, DeltaN-p53, produced by internal initiation of translation at codon 40 and lacking the N-terminal first transactivation domain. This isoform has impaired transcriptional activation capacity, and does not complex with the p53 regulatory protein Mdm2. Furthermore, DeltaN-p53 oligomerizes with full-length p53 (FL-p53) and negatively regulates its transcriptional and growth-suppressive activities. Consistent with the lack of Mdm2 binding, DeltaN-p53 does not accumulate in response to DNA-damage, suggesting that this isoform is not involved in the response to genotoxic stress. However, in serum-starved cells expressing wild-type p53, DeltaN-p53 becomes the predominant p53 form during the synchronous progression into S phase after serum stimulation. These results suggest that DeltaN-p53 may play a role as a transient, negative regulator of p53 during cell cycle progression.

Published
2002
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