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14. Operational definitions of asthma in studies on its aetiology

Author

Pekkanen, J, Sunyer, J, Anto, Jm, Burney, Pl, Abramson, M, Kutin, J, Vermeire, P, van Bastelaer, F, Bousquet, J, Neukirch, F, Liard, R, Pin, I, Pison, C, Taytard, A, Magnussen, H, Nowak, D, Wichmann, He, Heinrich, J, Gislason, T, Gislason, D, Prichard, J, Allwright, S, Macleod, D, Bugiani, M, Bucca, Caterina, Romano, Canzio, de Marco, R, Lo Cascio, V, Campello, C, Marinoni, A, Cerveri, I, Casali, L, Rijcken, B, Kremer, A, Crane, J, Lewis, S, Gulsvik, A, Omenaas, E, Soriano, J, Tobías, A, Roca, J, Kogevinas, M, Muniozguren, N, Ramos González, J, Capelastegui, A, Martinez Moratalla, J, Almar, E, Maldonado, J, Pereira, A, Sánchez, J, Payo, F, Huerta, I, Boman, G, Janson, C, Bjornsson, E, Rosenhall, L, Norrman, E, Lundback, B, Lindholm, N, Plaschke, P, Ackermann Liebrich, U, Künzli, N, Perruchoud, A, Burr, M, Layzqll, J, Hall, R, Harrison, B, Stark, J, Chinn, S, Luczynska, C, Jarvis, D, Lai, E, Buist, S, Vollmer, W, and Osborne, M.

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Multivariate analysis, Cross-sectional study, International Cooperation, Asthma, definition, epidemiology, method, risk factor, Sensitivity and Specificity, Severity of Illness Index, Age Distribution, immune system diseases, Risk Factors, Surveys and Questionnaires, Severity of illness, Epidemiology, medicine, Confidence Intervals, Prevalence, Humans, Risk factor, Sex Distribution, Respiratory Sounds, business.industry, Airway Resistance, Odds ratio, Middle Aged, medicine.disease, Prognosis, respiratory tract diseases, Respiratory Function Tests, Cross-Sectional Studies, Dyspnea, Bronchial hyperresponsiveness, Multivariate Analysis, Physical therapy, Female, business, Clinical psychology
Abstract

The most popular way to define asthma based on questionnaires is to use definitions taken from cross-sectional international studies on asthma. These definitions may not, however, be optimal for future studies focusing on risk factors of asthma. The current authors, therefore, compared the performance of different operational definitions of asthma. The European Community Respiratory Health Study I was a cross-sectional study of 21,924 subjects aged between 25-44 yrs in 18 countries. Operational definitions of asthma compared included different combinations of symptoms of asthma and bronchial hyperresponsiveness. A continuous asthma score, ranging from 0-8, was defined as the sum of positive answers to eight main symptom questions. There was no threshold in the associations of asthma symptoms with severity or risk factors of asthma, which would have suggested a dichotomous definition of asthma. Using dichotomous definitions requiring the presence of several asthma symptoms strengthened associations with studied risk factors, and also increased the estimated specificity and positive predictive value. Using a continuous asthma score also improved the power of the analyses. In conclusion, dichotomous definitions of asthma yielding higher odds ratios are achieved by requiring positive responses to several questions on symptoms. However, symptoms of asthma are possibly best analysed as a continuous asthma score.

Published
2005

15. Housing characteristics, reported mold exposure, and asthma in the European Community Respiratory Health Survey

Author

Zock, Jp, Jarvis, D, Luczynska, C, Sunyer, J, Burney, P, Burney, on behalf of the European Community Respiratory Health S. u. r. v. e. y. Principal participants of the ECRHS study Coordinating Center: P., Chinn, S., Luczynska, C., Jarvis, D., Lai, E., Australia: M. Abramson, J. Kutin, Belgium: P. Vermeire, F. van Bastelaer, Nielsen, Denmark: N., Jogi, Estonia: R., Bousquet, France: J., Neukirch, F., Liard, R., Pin, I., Pison, C., Taytard, A., Germany: H. Magnussen, D. Nowak, H. E. Wichmann, J. Heinrich, Iceland: T. Gislason, D. Gislason, Chowgule, India: R., Prichard, Ireland: J., Allwright, S., Macleod, D., Bugiani, Italy: M., Bucca, Caterina, Romano, Canzio, de Marco, R., Lo Cascio, V., Campello, C., Marinoni, A., Cerveri, I., Casali, L., The Netherlands: B. Rijcken, A. Kremer, New Zealand: J. Crane, S. Lewis, Gulsvik, Norway: A., Omenaas, E., Svanes, C., Antó, Spain: J., Sunyer, J., Soriano, J., Tobías, A., Roca, J., Kogevinas, M., Muniozguren, N., Ramos González, J., Capelastegui, A., Martinez Moratalla, J., Almar, E., Maldonado, J., Pereira, A., Sánchez, J., Payo, F., Huerta, I., Boman, Sweden: G., Janson, C., Björnsson, E., Rosenhall, L., Norrman, E., Lundback, B., Lindholm, N., Plaschke, P., Ackermann Liebrich, Switzerland: U., Künzli, N., Perruchoud, A., Burr, United Kingdom: M., Layzqll, J., Hall, R., Harrison, B., Stark, J., Buist, United States: S., Vollmer, W., and Osborne, M.

Subjects
MOLDS, HOUSING, ASTHMA
Published
2002

16. Variations in the prevalence across countries of chronic bronchitis and smoking habits in young adults

Author

Cerveri, I., Accordini, S., Verlato, G., Corsico, A., Zoia, M. C., Casali, L., Burney, P., de Marco, . R., Popp, for the European Community Respiratory Health Survey Study G. r. o. u. p. W., M. Abramson, J. Kutin, P. Vermeire, F. van Bastelaer, Bousquet, J., Knani, J., Neukirch, F., Liard, R., Pin, I., Pison, C., Taytard, A., Magnussen, H., Nowak, D., Wichmann, H. E., Heinrich, J., Papageorgiou, N., Avarlis, P., Gaga, M., Marossis, C., T. Gislason, D. Gislason, Prichard, J., Allwright, S., Macleod, D., Bugiani, M., Bucca, Caterina, Romano, Canzio, de Marco, R., Lo Cascio, V., Campello, C., Marinoni, A., B. Rijcken, A. Kremer, J. Crane, S. Lewis, A. Gulsvik, E. Omenaas, J. A. Marques, J. Alves, Anto`, J. M., Sunyer, J., Burgos, F., Castellsangue´, J., Roca, J., Soriano, J. B., Tobıas, A., Muniozguren, N., Ramos Gonzales, J., Capelastegui, A., Castillo, J., Rodriguez Portal, J., Martinez Moratalla, J., Almar, E., Maldonado Perez, J., Pereira, A., Sanchez, J., Quiros, J., Huerta, I., Pavo, F., Boman, G., Janson, C., Bjornsson, E., Rosenhall, L., Norrman, E., Lundback, B., Lindholm, N., Plaschke, P., Ackermann Liebrich, U., Kunzli, N., Perruchoud, A., Burr, M., Layzell, J., Hall, R., Harrison, B., Stark, J., Buist, S., Vollmer, W., and Osborne, M.

Subjects
chronic bronchitis, smoking
Published
2001

17. Occupation, Chronic Bronchitis, and Lung Function in Young Adults

Author

JAN PAUL ZOCK, Jordi, Sunyer, Manolis, Kogevinas, Hans, Kromhout, Peter, Burney, JOSEP MARIA ANTÓ, Abramson, The ECRHS Study Group: M., Kutin, J., Australia, Vermeire, P., F. van Bastelaer, Belgium, Magnussen, H., Nowak, D., Wichmann, H. E., Heinrich Germany, J., Gislason, T., Gislason Iceland, D., J. Prichard, S. Allwright, MacLeod Ireland, D., Bugiani, M., Bucca, Caterina, Romano, Canzio, de Marco, R., Cascio, Lo, Campello, C., Marinoni, A., Cerveri, I., Casali, L., Perfetti Italy, L., Rijcken, B., Schouten, J. P., Kerkhof, M., H. M. Boezen, The Netherlands, J. Crane, S. Lewis, Pearce New Zealand, N., Gulsvik, A., Omenaas Norway, E., Antó, J. M., Sunyer, J., Soriano, J., Kogevinas, M., Tobías, A., Roca, J., Muniozguren, N., Ramos González, J., A. Capelastegui, J. Martínez Moratalla, Almar, E., Maldonado Pérez, J., Pereira, A., Sánchez, J., Quirós, J., I. Huerta, Spain, G. Boman, C. Janson, Björnsson, E., Rosenhall, L., Norrman, E., Lundbäck, B., N. Lindholm, P. Plaschke, Torén Sweden, K., Künzli Switzerland, N., R. Hall, B. Harrison, Stark United Kingdom, J., S. Buist, W. Vollmer, Osborne Oregon, M., Kromhout, H., Vermeulen, R., Utrecht, and The, Netherland

Subjects
occupation, chronic bronchitis, lung function
Published
2001

18. International variations in asthma treatment compliance

Author

Cerveri, I., Locatelli, F., Zoia, M. C., Corsico, A., Accordini, S., de Marco, R., Popp, on behalf of the ECRHS Austria: W., Abramson, A. u. s. t. r. a. l. i. a. :. M., Kutin, J., Vermeire, Belgium: P., van Bastelaer, F., Bousquet, France: J., Knani, J., Neukirch, F., Liard, R., Pin, I., Pison, C., Taytard, A., Magnussen, Germany: H., Nowak, D., Wichmann, H. E., Heinrich, J., Papageorgiou, Greece: N., Avarlis, P., Gaga, M., Marossis, C., Gislason, Iceland: T., Gislason, D., Prichard, Ireland: J., Allwright, S., Macleod, D., Bugiani, Italy: M., Bucca, Caterina, Romano, Canzio, Cascio, L., Campello, C., Marinoni, A., Casali, L., Rijcken, the Netherlands: B., Kremer, A., Crane, New Zealand: J., Lewis, S., Gulsvik, Norway: A., Omenaas, E., Marques, Portugal: J. A., Alves, J., Antoá, Spain: J. M., Sunyer, J., Burgos, F., Castellsangueâ, J., Roca, J., Soriano, J. B., Tobiáas, A., Muniozguren, N., Ramos GonzaÁles, J., Capelastegui, A., Castillo, J., Rodriguez Portal, J., Martinez Moratalla, J., Almar, E., Maldonado PeÂrez, J., Pereira, A., Saánchez, J., Quiros, J., Huerta, I., Pavo, F., Boman, Sweden: G., Janson, C., Bjornsson, E., Rosenhall, L., Norrman, E., Lundback, B., Lindholm, N., Plaschke, P., Ackermann Liebrich, Switzerland: U., Kunzli, N., Perruchoud, A., Burr, UK: M., Layzell, J., Hall, R., Harrison, B., Stark, J., Buist, USA: S., Vollmer, W., and Osborne, M.

Subjects
asthma, treatment compliance
Published
1999

19. Occupational asthma in Europe and other industrialised areas: a population-based study

Author

Manolis, Kogevinas, Josep Maria Antó, Jordi, Sunyer, Aurelio, Tobias, Hans, Kromhout, Peter, Burney, Abramson, the European Community Respiratory Health Survey Study Group A. u. s. t. r. a. l. i. a— M., Vermeire, J. K. u. t. i. n. B. e. l. g. i. u. m—P., Magnussen, F. van Bastelaer . G. e. r. m. a. n. y— H., Nowak, D., H. E. W. i. c. h. m. a. n. n., Heinrich, J, Gislason, M. W. j. s. t. I. c. e. l. a. n. d— T., Prichard, D. G. i. s. l. a. s. o. n. I. r. e. l. a. n. d— J., Allwright, S., Bugiani, D. M. a. c. L. e. o. d. I. t. a. l. y— M., Bucca, Caterina, Romano, Canzio, R. de Marco lo Cascio, C. Campello, Marinoni, A., Cerveri, I., Crane, L. C. a. s. a. l. i. New Zealand— J., D’Souza, W., Pearce, N., Barry, D., Gulsvik, I. T. o. w. n. N. o. r. w. a. y—A., Omenaas, E., Antó, P. B. a. k. k. e. S. p. a. i. n— J. M., Sunyer, J., Soriano, J., Kogevinas, M., Tobias, A., Roca, J., Muniozguren, N., Ramos González, J., Capelastegui, A., J. Martinez Moratalla, E. Almar, Maldonade Pérez, J., Oereira, A., Sánchez, J., Quirós, J., Boman, I. Huerta . Sweden— G., Janson, C., Björnsson, E., Rosenhall, L., Norrman, E., Lundbäck, B., Lindholm, N., K— MBurr, P. P. l. a. s. c. h. k. e. U., Layzqll, J., Hall, R., Harrison, B., Buist, J. S. t. a. r. k. U. S. A— S., Vollmer, W., and Osborne, M.

Subjects
occupation, asthma
Published
1999

20. References values for forced spirometry

Author

Roca, J, Burgos, F, Sunyer, J, Saez, M, Chinn, S, Antó, Jm, Rodríguez Roisin, R, Quanjer, Ph, Nowak, D, Burney, P, Poop, for the Group of the European Community Respiratory Health S. u. r. v. e. y. Participating Centres: Austria: W., Australia: M. Abramson, J. Kutin, Belgium: P. Vermeire, F. van Bastelaer, Bousquet, France: J., Knani, J., Neukirch, F., Liard, R., Pin, I., Pison, C., Taytard, A., Germany: H. Magnussen, D. Nowak, H. E. Wichmann, J. Heinrich, Papageorgiou, Greece: N., Avarlis, P., Gaga, M., Marossis, C., Iceland: T. Gislason, D. Gislason, Prichard, Ireland: J., Allwright, S., Macleod, D., Bugiani, Italy: M., Bucca, Caterina, Romano, Canzio, de Marco Lo Cascio, R., Campello, . C., Marinoni, A., Cerveri, I., Casali, L., The Netherlands: B. Rijcken, A. Kremer, New Zealand: J. Crane, S. Lewis, Norway: A. Gulsvik, E. Omenaas, Portugal: J. A. Marques, J. Alves, Antó, Spain: J. M., Castellsagué, J., Sunyer, J., Soriano, J., Roca, J., Burgos, F., Tobías, A., Muniozguren, N., Ramos Gonzalez, J., Capelastegui, A., Castillo, J., Rodríguez Portal, J., Martínez Moratalla, J., Almar, E., Maldonado Pérez, J. A., Pereira, A., Sánchez, J., Quirós, J., Huerta, I., Payo, F., Boman, Sweden: G., Janson, C., Björnsson, E., Rosenhall, L., Norrman, E., Lundbäck, B., Lindholm, N., Plaschke, P., Ackermann Liebrich, Switzerland: U., Künzli, N., Perruchoud, A., Burr, UK: M., Layzell, J., Hall, . R., Harrison, B., Stark, J., Buist, USA: S., Vollmer, W., and Osborne, M.

Subjects
SPIROMETRY, REFERENCE VALUES
Published
1998

21. Remission of asthma : a prospective longitudinal study from northern Europe (RHINE study)

Author

Holm, M., Omenaas, E., Gíslason, T., Svanes, C., Jögi, Rain, Norrman, E., Janson, Christer, Torén, K., Holm, M., Omenaas, E., Gíslason, T., Svanes, C., Jögi, Rain, Norrman, E., Janson, Christer, and Torén, K.

Abstract

The aim of the present study was to investigate the remission rate of adult asthma in a general population sample in relation to age, sex, asthma symptoms, allergic rhinitis and smoking. A follow-up of the random population samples from the European Community Respiratory Health Survey in Northern Europe was conducted from 1999-2001 on 1,153 individuals (aged 26-53 yrs) with reported asthma. Remission was defined as no asthmatic symptoms in two consecutive years and no current use of asthma medication. Remission rates per 1,000 person-yrs were calculated and Cox regression models, adjusting for confounders, were used to estimate hazard ratios (HR) with 95% confidence intervals (CI). An average remission rate of 20.2 per 1,000 person-yrs was found. There was no significant difference according to sex; the remission rates were 21.7 and 17.8 per 1,000 person-yrs in females and males, respectively. An increased remission rate was observed among subjects who quit smoking during the observation period. Subjects not reporting any asthma symptom at baseline had an increased remission rate. In the Cox regression model, ex-smoking (HR 1.65P 95% Cl 1.01-2.71) was associated with increased remission rate, and reporting any asthma symptom at baseline was associated with decreased remission rate (HR 0.7, 95% Cl 0.40-0.90). In conclusion, the present prospective longitudinal study showed that quitting smoking and the presence of mild disease appeared to favour remission.

Published
2007
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22. Prevalence and incidence of respiratory symptoms in relation to indoor dampness : the RHINE study.

Author

Gunnbjörnsdóttir, Maria I, Franklin, K A, Norbäck, Dan, Björnsson, E, Gislason, D, Lindberg, Eva, Svanes, C, Omenaas, E, Norrman, E, Jögi, Rain, Jensen, E J, Dahlman-Höglund, A, Janson, Christer, Gunnbjörnsdóttir, Maria I, Franklin, K A, Norbäck, Dan, Björnsson, E, Gislason, D, Lindberg, Eva, Svanes, C, Omenaas, E, Norrman, E, Jögi, Rain, Jensen, E J, Dahlman-Höglund, A, and Janson, Christer

Published
2006

23. Variations in the prevalence of respiratory symptoms, selfreported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS)

Author

Burney, European Community Respiratory Health Survey: Co ordinating Centre: P., Chinn, S., Luczynska, C., Jarvis, D., Ait Khaled, E. L. a. i. Participating Centres: Algeria: N., Popp, Austria: W., Australia: M. Abramson, J. Kutin, Belgium: P. Vermeire, F. van Bastelaer, Denmark: R. Dahl, M. Iversen, Jögi, Estonia: R., Bousquet, France: J., Neukirch, F., Liard, R., Pin, I., Teculescu, C. Pison A. Taytard D., Germany: H. Magnussen, D. Nowak, H. E. Wichmann, J. Heinrich, Papageorgiou, Greece: N., Avarlis, P., Gaga, M., Marossis, C., Gislason, Iceland: T. Gislason D., Chowgule, India: R., Prichard, Ireland: J., Allwright, S., Macleod, D., Bugiani, Italy: M., Bucca, Caterina, Romano, Canzio, de Marco, R., Lo Cascio, V., Campello, C., Marinoni, A., Cerveri, I., Casali, L., The Netherlands: B. Rijcken, A. Kremer, New Zealand: J. Crane, S. Lewis, Norway: A. Gulsvik, E. Omenaas, Avila, Portugal: R., Amaral Marques, R., Loureiro, C., Chieira, C., Cordeiro, R., Marques, J. A., Alves, J., Anto, Spain: J., Castellsague, J., Sunyer, J., Soriano, J., Roca, M. Galobardes J., Muniozguren, N., Ramos González, J., Capelastegui, A., Castillo, J., Martinez Moratalla, J. Rodriguez P. o. r. t. a. l. J., Almar, E., Pereira, J. Maldonado Pérez A., Sánchez, J., Quiros, J., Huerta, I., Boman, Sweden: G., Janson, C., Björnsson, E., Rosenhall, L., Norrman, E., Lundbäck, B., Lindholm, N., Plaschke, P., Ackermann Liebrich, Switzerland: U., Künzli, N., Perruchoud, A., Burr, United Kingdom: M., Layzell, J., Hall, R., Harrison, B., Stark, J., Florey, C., da Costa Pereira, A., Clark, R., Buist, USA: S., Vollmer, W., and Osborne, M.

Subjects
therapy, respiratory symptos, asthma
Published
1996

24. A factorial experiment on image quality and radiation dose

Author

Norrman, E., Persliden, Jan, Norrman, E., and Persliden, Jan

Abstract

To find if factorial experiments can be used in the optimisation of diagnostic imaging, a factorial experiment was performed to investigate some of the factors that influence image quality, kerma area product (KAP) and effective dose (E). In a factorial experiment the factors are varied together instead of one at a time, making it possible to discover interactions between the factors as well as major effects. The factors studied were tube potential, tube loading, focus size and filtration. Each factor was set to two levels (low and high). The influence of the factors on the response variables (image quality, KAP and E) was studied using a direct digital detector. The major effects of each factor on the response variables were estimated as well as the interaction effects between factors. The image quality, KAP and E were mainly influenced by tube loading, tube potential and filtration. There were some active interactions, for example, between tube potential and filtration and between tube loading and filtration. The study shows that factorial experiments can be used to predict the influence of various parameters on image quality and radiation dose. © The Author 2005. Published by Oxford University Press. All rights reserved.

Published
2005
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25. Is birth size related to lung function and symptoms in Nordic-Baltic adults?

Author

Laerum, BN, Omenaas, E, Gulsvik, A, Iversen, M, Thorarinsdottir, HR, Gislason, T, Jögi, R, Norrman, E, Gunbjörnsdottir, Maria, Janson, Christer, Laerum, BN, Omenaas, E, Gulsvik, A, Iversen, M, Thorarinsdottir, HR, Gislason, T, Jögi, R, Norrman, E, Gunbjörnsdottir, Maria, and Janson, Christer

Published
2004

27. Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms.

Author

Gunnbjörnsdóttir, M I, Omenaas, E, Gíslason, T, Norrman, E, Olin, A C, Jõgi, R, Jensen, E J, Lindberg, E, Björnsson, E, Franklin, K, Janson, C, Gulsvik, A, Laerum, B, Svanes, C, Torén, K, Tunsäter, A, Lillienberg, L, Gíslason, D, Blöndal, T, Björnsdottir, U S, Jörundsdóttir, K B, Talvik, R, Forsberg, B, Lundbäck, B, Söderberg, M, Ledin, M C, Boman, G, Norbäck, D, Wieslander, G, Spetz-Nyström, U, Cashelunge, K Stenudd, Rydén, E, Gunnbjörnsdóttir, M I, Omenaas, E, Gíslason, T, Norrman, E, Olin, A C, Jõgi, R, Jensen, E J, Lindberg, E, Björnsson, E, Franklin, K, Janson, C, Gulsvik, A, Laerum, B, Svanes, C, Torén, K, Tunsäter, A, Lillienberg, L, Gíslason, D, Blöndal, T, Björnsdottir, U S, Jörundsdóttir, K B, Talvik, R, Forsberg, B, Lundbäck, B, Söderberg, M, Ledin, M C, Boman, G, Norbäck, D, Wieslander, G, Spetz-Nyström, U, Cashelunge, K Stenudd, and Rydén, E

Published
2004

33. Metal artefact reduction in CT imaging of hip prosthesesan-evaluation of commercial techniques provided by four vendors.

Author

ANDERSSON, K. M., NOWIK, P., PERSLIDEN, J., THUNBERG, P., and NORRMAN, E.

Subjects
MEDICAL artifacts, COMPUTED tomography, ARTIFICIAL hip joints, MONOENERGETIC radiation, IMAGE quality in imaging systems
Abstract

Objective: The aim of this study was to evaluate commercial metal artefact reduction (MAR) techniques in X-ray CT imaging of hip prostheses. Methods: Monoenergetic reconstructions of dual-energy CT (DECT) data and several different MAR algorithms, combined with single-energy CT or DECT, were evaluated by imaging a bilateral hip prosthesis phantom. The MAR images were compared with uncorrected images based on CT number accuracy and noise in different regions of interest. Results: The three MAR algorithms studied implied a general noise reduction (up to 67%, 74% and 77%) and an improvement in CT number accuracy, both in regions close to the prostheses and between the two prostheses, The application of monoenergetic reconstruction, without any MAR algorithm, did not decrease the noise in the regions close to the prostheses to the same extent as did the MAR algorithms and even increased the noise in the region between the prostheses. Conclusion: The MAR algorithms evaluated generally improved CT number accuracy and substantially reduced the noise in the hip prostheses phantom images, both close to the prostheses and between the two prostheses. The study showed that the monoenergetic reconstructions evaluated did not sufficiently reduce the severe metal artefact caused by large orthopaedic implants. Advances in knowledge: This study evaluates several commercially available MAR techniques in CT imaging of large orthopaedic implants. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Association between atopic sensitization and asthma and bronchial hyperresponsiveness in Swedish adults: Pets, and not mites, are the most important allergens

Author

Plaschke, P., Janson, C., Norrman, E., Bjornsson, E., Ellbjar, S., and Jarvholm, B.

Abstract

Background: Atopic sensitization is a well-known risk factor for asthma and bronchial hyperresponsiveness (BHR). Mites have been regarded as the most important allergens, but the prevalence of sensitization to mites is relatively low in Sweden. Objective: The aim of the study was to investigate possible associations between sensitization to various allergens and asthma and BHR in adults. Methods: A random sample of 1859 subjects, aged 20 to 46 years, was investigated in a cross-sectional study by using a questionnaire, skin prick tests (SPTs), specific and total IgE measurements, and methacholine bronchial challenge tests. Possible associations were analyzed univariately and by using multivariate logistic regression analysis and proportional hazard regression analysis. Results: Positive SPT and specific IgE results were more common in subjects with asthma and BHR than in subjects without these conditions for all allergens. The independent associations between positive SPT responses and asthma and BHR are given as adjusted prevalence ratios (PRRs): pets and asthma, PRR = 3.6; pets and BHR, PRR = 2.0; grass and asthma, PRR = 2.0; grass and BHR, PRR = 1.7; mites and asthma, PRR = 1.4; and mites and BHR, PRR = 1.2. The use of specific IgE measurements instead of SPTs showed essentially similar results. Conclusion: Cats and dogs were the sensitizing allergens most closely associated with asthma and BHR. The relationships with sensitization to grass and mites were less pronounced. (J Allergy Clin Immunol 1999;103:58-65.)

Published
1999
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50. Genes for asthma? An analysis of the European Community Respiratory Health Survey

Author

Burney, P., Chinn, S., Luczynska, C., Jarvis, D., Vermeire, P., Bousquet, J., Nowak, D., Prichard, J., Marco, R., Rijcken, B., Anto, J., Alves, J., Boman, G., Nielsen, N., Paoletti, P., Kesteloot, H., Ait-Khaled, N., Popp, W., Michael Abramson, Kutin, J., Bastelaer, F., Dahl, R., Iversen, M., Jögi, R., Neukirch, F., Liard, R., Pin, I., Pison, C., Taytard, A., Teculescu, D., Magnussen, H., Heinrich, J., Wichmann, H. E., Papageorgiou, N., Avarlis, P., Gaga, M., Marossis, C., Gislason, T., Gislason, D., Chowgule, R., Allwright, S., Macleod, D., Bugiani, M., Bucca, C., Romano, C., Marco Lo Cascio, R., Campello, C., Marinoni, A., Cerveri, I., Casali, L., Kresmer, A., Crane, J., Lewis, S., Gulsvik, A., Omenaas, E., Avila, R., Amaral Marques, R., Loureiro, C., Chieira, C., Cordeiro, R., Marques, J. A., Castellasague, J., Sunyer, J., Soriano, J., Galobardes, M., Roca, J., Muniozguren, N., Ramos, J., Ramos González, J., Capelastegui, A., Castillo, J., Rodriguez Portal, J., Martinez-Motatella, J., Almar, E., Maldonado Pérez, J., Pereira, A., Sánchez, J., Quiros, J., Huerta, I., Janson, C., Björnsson, E., Rosenhall, L., Norrman, E., Lundbät, B., Lindholm, N., Plaschke, P., Ackermann-Liebrich, U., Künzli, N., Perruchoud, A., Burr, M., Layzell, J., Hall, R., Harrison, B., Stark, J., Florey, C., Da Costa Pereira, A., and Wjst, M.

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