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594 results on '"Norman JR"'

12. TAKING STOCK OF THE EFFICIENCIES DEFENSE: LESSONS FROM RECENT HEALTH CARE MERGER REVIEWS AND CHALLENGES.

Author

Armstrong, Norman, Jr. and Ramanarayanan, Subramaniam

Subjects
Industrial efficiency -- Research, Health care industry -- Mergers, acquisitions and divestments -- Research, Acquisitions and mergers -- Research, Health care industry, Company acquisition/merger
Abstract

The U.S. health care industry continues to consolidate as health care providers and payors explore mergers and other contractual arrangements to address uncertainties created by changes in technology, regulations, and [...]

Published
2018

19. Role of ELOVL4 in Fatty Acid Metabolism

Author

Vasireddy, Vidyullatha, Sharon, Majchrzak, Salem, Norman, Jr, Ayyagari, Radha, Back, Nathan, editor, Cohen, Irun R., editor, Abel Lajtha, N.S., editor, Lambris, John D., editor, Paoletti, Rodolfo, editor, Anderson, Robert E., editor, LaVail, Matthew M., editor, and Hollyfield, Joe G., editor

Published
2008
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33. Data Point Averaging for Computational Fluid Dynamics Data

Author

Norman, Jr., David

Subjects
Fluid Mechanics And Thermodynamics
Abstract

A system and method for generating fluid flow parameter data for use in aerodynamic heating analysis. Computational fluid dynamics data is generated for a number of points in an area on a surface to be analyzed. Sub-areas corresponding to areas of the surface for which an aerodynamic heating analysis is to be performed are identified. A computer system automatically determines a sub-set of the number of points corresponding to each of the number of sub-areas and determines a value for each of the number of sub-areas using the data for the sub-set of points corresponding to each of the number of sub-areas. The value is determined as an average of the data for the sub-set of points corresponding to each of the number of sub-areas. The resulting parameter values then may be used to perform an aerodynamic heating analysis.

Published
2016

43. Mass spectrometry-based discovery of circadian peptides

Author

Hatcher, Nathan G., Atkins, Norman, Jr., Annangudi, Suresh P., Forbes, Andrew J., Kelleher, Neil L., Gillette, Martha U., and Sweedler, Jonathan V.

Subjects
Neuropeptides -- Properties, Mass spectrometry -- Methods, Suprachiasmatic nucleus -- Research, Science and technology
Abstract

A significant challenge to understanding dynamic and heterogeneous brain systems lies in the chemical complexity of secreted intercellular messengers that change rapidly with space and time. Two solid-phase extraction collection strategies are presented that relate time and location of peptide release with mass spectrometric characterization. Here, complex suites of peptide-based cell-to-cell signaling molecules are characterized from the mammalian suprachiasmatic nucleus (SCN), site of the master circadian clock. Observed SCN releasates are peptide rich and demonstrate the co-release of established circadian neuropeptides and peptides with unknown roles in circadian rhythms. Additionally, the content of SCN releasate is stimulation specific. Stimulation paradigms reported to alter clock timing, including electrical stimulation of the retinohypothalamic tract, produce releasate mass spectra that are notably different from the spectra of compounds secreted endogenously over the course of the 24-h cycle. In addition to established SCN peptides, we report the presence of proSAAS peptides in releasates. One of these peptides, little SAAS, exhibits robust retinohypothalamic tract-stimulated release from the SCN, and exogenous application of little SAAS induces a phase delay consistent with light-mediated cues regulating circadian timing. These mass spectrometry-based analyses provide a new perspective on peptidergic signaling within the SCN and demonstrate that the integration of secreted compounds with information relating time and location of release generates new insights into intercellular signaling in the brain. little SAAS | neuropeptides | solid-phase extraction | peptidomics | suprachiasmatic nucleus

Published
2008

46. Increased dietary intake of [omega]-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis

Author

Connor, Kip M, SanGiovanni, John Paul, Lofqvist, Chatarina, Aderman, Christopher M, Chen, Jing, Higuchi, Akiko, Hong, Song, Pravda, Elke A, Majchrzak, Sharon, Carper, Deborah, Hellstrom, Ann, Kang, Jing X, Chew, Emily Y, Salem, Norman, Jr, Serhan, Charles N, and Smith, Lois E H

Abstract

Author(s): Kip M Connor [1, 9]; John Paul SanGiovanni [2, 9]; Chatarina Lofqvist [1, 3]; Christopher M Aderman [1]; Jing Chen [1]; Akiko Higuchi [1]; Song Hong [4]; Elke A [...]

Published
2007
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50. Lead exposure and (n-3) fatty acid deficiency during rat neonatal development affect subsequent spatial task performance and olfactory discrimination

Author

Lim, Sun-Young, Doherty, John D., McBride, Kathleen, Miller-Ihli, Nancy J., Carmona, Gilberto N., Stark, Ken D., and Salem, Norman, Jr.

Subjects
Smell disorders -- Research, Fatty acid metabolism -- Research, Infants (Newborn) -- Diseases, Infants (Newborn) -- Research, Food/cooking/nutrition
Abstract

Docosahexaenoic acid [22:6(n-3), DHA] is important for optimal infant central nervous system development, and lead (Pb) exposure during development can produce neurological deficits. Long-Evans strain rats were fed either an (n-3) deficient [(n-3) Def] diet to produce brain DHA deficiency, or an adequate [(n-3) Adq] diet through 2 generations. At the birth of the 2nd generation, the dams were subdivided into 4 groups and supplied drinking water containing either 5.27 mmol/L (Pb) or sodium (Na) acetate until weaning. Rats were killed at 3 wk (weaning) and 11 wk (maturity) for brain Pb and fatty acid analysis. Spatial task and olfactory-cued behavioral assessments were initiated at 9 wk. Rats in the (n-3) Def group had a 79% lower concentration of brain DHA compared with the (n-3) Adq group with no effect of Pb exposure. At weaning, Pb concentrations were 7.17 [+ or -] 0.47 nmol Pb/g of brain (wet weight) in the (n-3) Adq-Pb group and 6.49 [+ or -] 0.63 nmol Pb/g of brain (wet weight) in the (n-3) Def-Pb group. At maturity, the brains contained 1.30 [+ or -] 0.22 and 1.07 [+ or -] 0.12 nmol Pb/g (wet weight), respectively. In behavioral testing, significant effects of both Pb and DHA deficiency were observed in the Morris water maze probe trial and in 2-odor olfactory discrimination acquisition and olfactory-based reversal learning tasks. Both lactational Pb exposure and (n-3) fatty acid deficiency led to behavioral deficits with additive effects observed only in the acquisition of 2-odor discriminations. KEY WORDS: * (n-3) fatty acid deficiency * neonatal development * spatial learning * olfactory discriminations * lead toxicity * Pb

Published
2005

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