230 results on '"Norddahl, Gudmundur L"'
Search Results
2. Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease
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Saevarsdottir, Saedis, Bjarnadottir, Kristbjörg, Markusson, Thorsteinn, Berglund, Jonas, Olafsdottir, Thorunn A., Halldorsson, Gisli H., Rutsdottir, Gudrun, Gunnarsdottir, Kristbjorg, Arnthorsson, Asgeir Orn, Lund, Sigrun H., Stefansdottir, Lilja, Gudmundsson, Julius, Johannesson, Ari J., Sturluson, Arni, Oddsson, Asmundur, Halldorsson, Bjarni, Ludviksson, Björn R., Ferkingstad, Egil, Ivarsdottir, Erna V., Sveinbjornsson, Gardar, Grondal, Gerdur, Masson, Gisli, Eldjarn, Grimur Hjorleifsson, Thorisson, Gudmundur A., Kristjansdottir, Katla, Knowlton, Kirk U., Moore, Kristjan H. S., Gudjonsson, Sigurjon A., Rognvaldsson, Solvi, Knight, Stacey, Nadauld, Lincoln D., Holm, Hilma, Magnusson, Olafur T., Sulem, Patrick, Gudbjartsson, Daniel F., Rafnar, Thorunn, Thorleifsson, Gudmar, Melsted, Pall, Norddahl, Gudmundur L., Jonsdottir, Ingileif, and Stefansson, Kari
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- 2024
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3. Author Correction: Large-scale plasma proteomics comparisons through genetics and disease associations
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Eldjarn, Grimur Hjorleifsson, Ferkingstad, Egil, Lund, Sigrun H., Helgason, Hannes, Magnusson, Olafur Th., Gunnarsdottir, Kristbjorg, Olafsdottir, Thorunn A., Halldorsson, Bjarni V., Olason, Pall I., Zink, Florian, Gudjonsson, Sigurjon A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Gisli H., Magnusson, Magnus K., Saevarsdottir, Saedis, Eiriksdottir, Thjodbjorg, Masson, Gisli, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorleifsson, Gudmar, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2024
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4. Histopathology and levels of proteins in plasma associate with survival after colorectal cancer diagnosis
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Magnusson, Magnus I., Agnarsson, Bjarni A., Jonasson, Jon G., Tryggvason, Thordur, Aeffner, Famke, le Roux, Louise, Magnusdottir, Droplaug N., Gunnarsdottir, Helga S., Alexíusdóttir, Kristín K., Gunnarsdottir, Kristbjorg, Söebech, Emilia, Runarsdottir, Hjaltey, Jonsdottir, Erna M., Kristinsdottir, Bjarney S., Olafsson, Sigurgeir, Knutsdottir, Hildur, Thorsteinsdottir, Unnur, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Saemundsdottir, Jona, Magnusson, Olafur T., Norddahl, Gudmundur L., Watson, J. E. Vivienne, Rafnar, Thorunn, Lund, Sigrun H., and Stefansson, Kari
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- 2023
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5. Large-scale plasma proteomics comparisons through genetics and disease associations
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Eldjarn, Grimur Hjorleifsson, Ferkingstad, Egil, Lund, Sigrun H., Helgason, Hannes, Magnusson, Olafur Th., Gunnarsdottir, Kristbjorg, Olafsdottir, Thorunn A., Halldorsson, Bjarni V., Olason, Pall I., Zink, Florian, Gudjonsson, Sigurjon A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Gisli H., Magnusson, Magnus K., Saevarsdottir, Saedis, Eiriksdottir, Thjodbjorg, Masson, Gisli, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorleifsson, Gudmar, Ulfarsson, Magnus O., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2023
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6. Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria
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Kristjansson, Ragnar P., Oskarsson, Gudjon R., Skuladottir, Astros, Oddsson, Asmundur, Rognvaldsson, Solvi, Sveinbjornsson, Gardar, Lund, Sigrun H., Jensson, Brynjar O., Styrmisdottir, Edda L., Halldorsson, Gisli H., Ferkingstad, Egil, Eldjarn, Grimur Hjorleifsson, Beyter, Doruk, Kristmundsdottir, Snædis, Juliusson, Kristinn, Fridriksdottir, Run, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Snorradottir, Margret H., Tragante, Vinicius, Stefansdottir, Lilja, Ivarsdottir, Erna V., Bjornsdottir, Gyda, Halldorsson, Bjarni V., Thorleifsson, Gudmar, Ludviksson, Bjorn R., Onundarson, Pall T., Saevarsdottir, Saedis, Melsted, Pall, Norddahl, Gudmundur L., Bjornsdottir, Unnur S., Olafsdottir, Thorunn, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari
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- 2023
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7. A partial loss-of-function variant in STAT6 protects against type 2 asthma
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Kristjansdottir, Katla, Norddahl, Gudmundur L., Ivarsdottir, Erna V., Halldorsson, Gisli H., Einarsson, Gudmundur, Bjarnadottir, Kristbjorg, Rutsdottir, Gudrun, Arnthorsson, Asgeir O., Erikstrup, Christian, Gudmundsdottir, Steinunn, Gunnarsdottir, Kristbjorg, Gunnbjornsdottir, Maria I., Halldorsson, Bjarni V., Holm, Hilma, Ludviksdottir, Dora, Ludviksson, Bjorn R., Brunak, Søren, Bruun, Mie Topholm, Mikkelsen, Christina, Mikkelsen, Susan, Jensen, Bitten Aagaard, Sørensen, Erik, Thomsen, Simon Francis, Ullum, Henrik, Olafsson, Isleifur, Onundarson, Pall T., Ostrowski, Sisse Rye, Saevarsdottir, Saedis, Sigurdardottir, Olof, Sigurgeirsson, Bardur, Snaebjarnarson, Audunn S., Sveinbjornsson, Gardar, Thorlacius, Gudny E., Thorleifsson, Gudmar, Tragante, Vinicius, Vidarsson, Brynjar, Porsbjerg, Celeste, Bjornsdottir, Unnur S., Sulem, Patrick, Gudbjartsson, Daniel F., Melsted, Pall, Pedersen, Ole Bv., Jonsdottir, Ingileif, Olafsdottir, Thorunn A., and Stefansson, Kari
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- 2024
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8. Multiomics study of nonalcoholic fatty liver disease
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Sveinbjornsson, Gardar, Ulfarsson, Magnus O., Thorolfsdottir, Rosa B., Jonsson, Benedikt A., Einarsson, Eythor, Gunnlaugsson, Gylfi, Rognvaldsson, Solvi, Arnar, David O., Baldvinsson, Magnus, Bjarnason, Ragnar G., Eiriksdottir, Thjodbjorg, Erikstrup, Christian, Ferkingstad, Egil, Halldorsson, Gisli H., Helgason, Hannes, Helgadottir, Anna, Hindhede, Lotte, Hjorleifsson, Grimur, Jones, David, Knowlton, Kirk U., Lund, Sigrun H., Melsted, Pall, Norland, Kristjan, Olafsson, Isleifur, Olafsson, Sigurdur, Oskarsson, Gudjon R., Ostrowski, Sisse Rye, Pedersen, Ole Birger, Snaebjarnarson, Auðunn S., Sigurdsson, Emil, Steinthorsdottir, Valgerdur, Schwinn, Michael, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Jonsdottir, Ingileif, Bundgaard, Henning, Nadauld, Lincoln, Bjornsson, Einar S., Rulifson, Ingrid C., Rafnar, Thorunn, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, Gudbjartsson, Daniel F., Holm, Hilma, and Stefansson, Kari
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- 2022
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9. Reconstruction of a large-scale outbreak of SARS-CoV-2 infection in Iceland informs vaccination strategies
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Hjorleifsson, Kristjan E., Rognvaldsson, Solvi, Jonsson, Hakon, Agustsdottir, Arna B., Andresdottir, Margret, Birgisdottir, Kolbrun, Eiriksson, Ogmundur, Eythorsson, Elias S., Fridriksdottir, Run, Georgsson, Gudmundur, Gudmundsson, Kjartan R., Gylfason, Arnaldur, Haraldsdottir, Gudbjorg, Jensson, Brynjar O., Jonasdotti, Adalbjorg, Jonasdottir, Aslaug, Josefsdottir, Kamilla S., Kristinsdottir, Nina, Kristjansdottir, Borghildur, Kristjansson, Thordur, Magnusdottir, Droplaug N., Palsson, Runolfur, le Roux, Louise, Sigurbergsdottir, Gudrun M., Sigurdsson, Asgeir, Sigurdsson, Martin I., Sveinbjornsson, Gardar, Thorarensen, Emil Aron, Thorbjornsson, Bjarni, Thordardottir, Marianna, Helgason, Agnar, Holm, Hilma, Jonsdottir, Ingileif, Jonsson, Frosti, Magnusson, Olafur T., Masson, Gisli, Norddahl, Gudmundur L., Saemundsdottir, Jona, Sulem, Patrick, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Melsted, Pall, and Stefansson, Kari
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- 2022
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10. Genetic architecture of band neutrophil fraction in Iceland
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Oskarsson, Gudjon R., Magnusson, Magnus K., Oddsson, Asmundur, Jensson, Brynjar O., Fridriksdottir, Run, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Rognvaldsson, Solvi, Halldorsson, Gisli H., Sveinbjornsson, Gardar, Ivarsdottir, Erna V., Stefansdottir, Lilja, Ferkingstad, Egil, Norland, Kristjan, Tragante, Vinicius, Saemundsdottir, Jona, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurjonsdottir, Svanhvit, Petursdottir, Karen O., Davidsson, Olafur B., Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T., Vidarsson, Brynjar, Sigurdardottir, Olof, Masson, Gisli, Gudbjartsson, Daniel F., Jonsdottir, Ingileif, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2022
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11. HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
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Olafsdottir, Thorunn A., Bjarnadottir, Kristbjorg, Norddahl, Gudmundur L., Halldorsson, Gisli H., Melsted, Pall, Gunnarsdottir, Kristbjorg, Ivarsdottir, Erna, Olafsdottir, Thorhildur, Arnthorsson, Asgeir O., Theodors, Fannar, Eythorsson, Elias, Helgason, Dadi, Eggertsson, Hannes P., Masson, Gisli, Bjarnadottir, Sólveig, Saevarsdottir, Saedis, Runolfsdottir, Hrafnhildur L., Olafsson, Isleifur, Saemundsdottir, Jona, Sigurdsson, Martin I., Ingvarsson, Ragnar F., Palsson, Runolfur, Thorgeirsson, Gudmundur, Halldorsson, Bjarni V., Holm, Hilma, Kristjansson, Mar, Sulem, Patrick, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Gudbjartsson, Daniel F., and Stefansson, Kari
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- 2022
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12. Effect of booster vaccination against Delta and Omicron SARS-CoV-2 variants in Iceland
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Norddahl, Gudmundur L., Melsted, Pall, Gunnarsdottir, Kristbjorg, Halldorsson, Gisli H., Olafsdottir, Thorunn A., Gylfason, Arnaldur, Kristjansson, Mar, Magnusson, Olafur T., Sulem, Patrick, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, and Stefansson, Kari
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- 2022
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13. Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene
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Arnadottir, Gudny A., Oddsson, Asmundur, Jensson, Brynjar O., Gisladottir, Svanborg, Simon, Mariella T., Arnthorsson, Asgeir O., Katrinardottir, Hildigunnur, Fridriksdottir, Run, Ivarsdottir, Erna V., Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Barrick, Rebekah, Saemundsdottir, Jona, le Roux, Louise, Oskarsson, Gudjon R., Asmundsson, Jurate, Steffensen, Thora, Gudmundsson, Kjartan R., Ludvigsson, Petur, Jonsson, Jon J., Masson, Gisli, Jonsdottir, Ingileif, Holm, Hilma, Jonasson, Jon G., Magnusson, Olafur Th., Thorarensen, Olafur, Abdenur, Jose, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Bjornsson, Hans T., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2022
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14. Author Correction: Functional dissection of inherited non-coding variation influencing multiple myeloma risk
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Ajore, Ram, Niroula, Abhishek, Pertesi, Maroulio, Cafaro, Caterina, Thodberg, Malte, Went, Molly, Bao, Erik L., Duran-Lozano, Laura, Lopez de Lapuente Portilla, Aitzkoa, Olafsdottir, Thorunn, Ugidos-Damboriena, Nerea, Magnusson, Olafur, Samur, Mehmet, Lareau, Caleb A., Halldorsson, Gisli H., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gunnarsdottir, Kristbjorg, Försti, Asta, Goldschmidt, Hartmut, Hemminki, Kari, van Rhee, Frits, Kimber, Scott, Sperling, Adam S., Kaiser, Martin, Anderson, Kenneth, Jonsdottir, Ingileif, Munshi, Nikhil, Rafnar, Thorunn, Waage, Anders, Weinhold, Niels, Thorsteinsdottir, Unnur, Sankaran, Vijay G., Stefansson, Kari, Houlston, Richard, and Nilsson, Björn
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- 2022
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15. Functional dissection of inherited non-coding variation influencing multiple myeloma risk
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Ajore, Ram, Niroula, Abhishek, Pertesi, Maroulio, Cafaro, Caterina, Thodberg, Malte, Went, Molly, Bao, Erik L., Duran-Lozano, Laura, Lopez de Lapuente Portilla, Aitzkoa, Olafsdottir, Thorunn, Ugidos-Damboriena, Nerea, Magnusson, Olafur, Samur, Mehmet, Lareau, Caleb A., Halldorsson, Gisli H., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gunnarsdottir, Kristbjorg, Försti, Asta, Goldschmidt, Hartmut, Hemminki, Kari, van Rhee, Frits, Kimber, Scott, Sperling, Adam S., Kaiser, Martin, Anderson, Kenneth, Jonsdottir, Ingileif, Munshi, Nikhil, Rafnar, Thorunn, Waage, Anders, Weinhold, Niels, Thorsteinsdottir, Unnur, Sankaran, Vijay G., Stefansson, Kari, Houlston, Richard, and Nilsson, Björn
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- 2022
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16. Large-scale integration of the plasma proteome with genetics and disease
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Ferkingstad, Egil, Sulem, Patrick, Atlason, Bjarni A., Sveinbjornsson, Gardar, Magnusson, Magnus I., Styrmisdottir, Edda L., Gunnarsdottir, Kristbjorg, Helgason, Agnar, Oddsson, Asmundur, Halldorsson, Bjarni V., Jensson, Brynjar O., Zink, Florian, Halldorsson, Gisli H., Masson, Gisli, Arnadottir, Gudny A., Katrinardottir, Hildigunnur, Juliusson, Kristinn, Magnusson, Magnus K., Magnusson, Olafur Th., Fridriksdottir, Run, Saevarsdottir, Saedis, Gudjonsson, Sigurjon A., Stacey, Simon N., Rognvaldsson, Solvi, Eiriksdottir, Thjodbjorg, Olafsdottir, Thorunn A., Steinthorsdottir, Valgerdur, Tragante, Vinicius, Ulfarsson, Magnus O., Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Melsted, Pall, Saemundsdottir, Jona, Norddahl, Gudmundur L., Lund, Sigrun H., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, and Stefansson, Kari
- Published
- 2021
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17. Differences between germline genomes of monozygotic twins
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Jonsson, Hakon, Magnusdottir, Erna, Eggertsson, Hannes P., Stefansson, Olafur A., Arnadottir, Gudny A., Eiriksson, Ogmundur, Zink, Florian, Helgason, Einar A., Jonsdottir, Ingileif, Gylfason, Arnaldur, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Beyter, Doruk, Steingrimsdottir, Thora, Norddahl, Gudmundur L., Magnusson, Olafur Th., Masson, Gisli, Halldorsson, Bjarni V., Thorsteinsdottir, Unnur, Helgason, Agnar, Sulem, Patrick, Gudbjartsson, Daniel F., and Stefansson, Kari
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- 2021
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18. Molecular benchmarks of a SARS-CoV-2 epidemic
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Jonsson, Hakon, Magnusson, Olafur T., Melsted, Pall, Berglund, Jonas, Agustsdottir, Arna B., Eiríksdottir, Berglind, Fridriksdottir, Run, Garðarsdottir, Elisabet Eir, Georgsson, Gudmundur, Gretarsdottir, Olafia S., Guðmundsson, Kjartan R., Gunnarsdottir, Thora Rosa, Eggertsson, Hannes, Gylfason, Arnaldur, Holm, Hilma, Jensson, Brynjar O., Jonasdottir, Aslaug, Jonsson, Frosti, Josefsdottir, Kamilla S., Thordardottir, Marianna, Kristinsson, Karl G., Kristjánsson, Þórður, Magnusdottir, Droplaug N., Roux, Louise le, Saemundsdottir, Jona, Sigurdsson, Asgeir, Sigmundsdottir, Gudrun, Sveinbjornsson, Gardar, Rognvaldsson, Solvi, Eiriksson, Ogmundur, Magnusson, Magnus Karl, Sveinsdottir, Kristin Eva, Sveinsdottir, Maney, Thorarensen, Emil Aron, Thorbjornsson, Bjarni, Löve, Arthur, Norddahl, Gudmundur L., Jonsdottir, Ingileif, Sulem, Patrick, Masson, Gisli, Moller, Alma, Gudnason, Thorolfur, Kristjansson, Mar, Helgason, Agnar, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2021
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19. Predicting the probability of death using proteomics
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Eiriksdottir, Thjodbjorg, Ardal, Steinthor, Jonsson, Benedikt A., Lund, Sigrun H., Ivarsdottir, Erna V., Norland, Kristjan, Ferkingstad, Egil, Stefansson, Hreinn, Jonsdottir, Ingileif, Holm, Hilma, Rafnar, Thorunn, Saemundsdottir, Jona, Norddahl, Gudmundur L., Thorgeirsson, Gudmundur, Gudbjartsson, Daniel F., Sulem, Patrick, Thorsteinsdottir, Unnur, Stefansson, Kari, and Ulfarsson, Magnus O.
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- 2021
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20. Lipoprotein(a) Concentration and Risks of Cardiovascular Disease and Diabetes
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Gudbjartsson, Daniel F., Thorgeirsson, Gudmundur, Sulem, Patrick, Helgadottir, Anna, Gylfason, Arnaldur, Saemundsdottir, Jona, Bjornsson, Eythor, Norddahl, Gudmundur L., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Eggertsson, Hannes P., Gretarsdottir, Solveig, Thorleifsson, Gudmar, Indridason, Olafur S., Palsson, Runolfur, Jonasson, Fridbert, Jonsdottir, Ingileif, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Danielsen, Ragnar, Matthiasson, Stefan E., Kristmundsdottir, Snaedis, Halldorsson, Bjarni V., Hreidarsson, Astradur B., Valdimarsson, Einar M., Gudnason, Thorarinn, Benediktsson, Rafn, Steinthorsdottir, Valgerdur, Thorsteinsdottir, Unnur, Holm, Hilma, and Stefansson, Kari
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- 2019
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21. FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease
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Saevarsdottir, Saedis, Olafsdottir, Thorunn A., Ivarsdottir, Erna V., Halldorsson, Gisli H., Gunnarsdottir, Kristbjorg, Sigurdsson, Asgeir, Johannesson, Ari, Sigurdsson, Jon K., Juliusdottir, Thorhildur, Lund, Sigrun H., Arnthorsson, Asgeir O., Styrmisdottir, Edda L., Gudmundsson, Julius, Grondal, Gerdur M., Steinsson, Kristjan, Alfredsson, Lars, Askling, Johan, Benediktsson, Rafn, Bjarnason, Ragnar, Geirsson, Arni J., Gudbjornsson, Bjorn, Gudjonsson, Hallgrimur, Hjaltason, Haukur, Hreidarsson, Astradur B., Klareskog, Lars, Kockum, Ingrid, Kristjansdottir, Helga, Love, Thorvardur J., Ludviksson, Bjorn R., Olsson, Tomas, Onundarson, Pall T., Orvar, Kjartan B., Padyukov, Leonid, Sigurgeirsson, Bardur, Tragante, Vinicius, Bjarnadottir, Kristbjorg, Rafnar, Thorunn, Masson, Gisli, Sulem, Patrick, Gudbjartsson, Daniel F., Melsted, Pall, Thorleifsson, Gudmar, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, and Stefansson, Kari
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- 2020
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22. A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis
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Kristjansson, Ragnar P., Benonisdottir, Stefania, Davidsson, Olafur B., Oddsson, Asmundur, Tragante, Vinicius, Sigurdsson, Jon K., Stefansdottir, Lilja, Jonsson, Stefan, Jensson, Brynjar O., Arthur, Joseph G., Arnadottir, Gudny A., Sulem, Gerald, Halldorsson, Bjarni V., Gunnarsson, Bjarni, Halldorsson, Gisli H., Stefansson, Olafur A., Oskarsson, Gudjon R., Deaton, Aimee M., Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Onundarson, Pall T., Gislason, David, Gislason, Thorarinn, Ludviksson, Bjorn R., Ludviksdottir, Dora, Olafsdottir, Thorunn A., Rafnar, Thorunn, Masson, Gisli, Zink, Florian, Bjornsdottir, Gyda, Magnusson, Olafur Th., Bjornsdottir, Unnur S., Thorleifsson, Gudmar, Norddahl, Gudmundur L., Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Sulem, Patrick, and Stefansson, Kari
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- 2019
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23. Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis
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Styrkarsdottir, Unnur, Lund, Sigrun H., Thorleifsson, Gudmar, Zink, Florian, Stefansson, Olafur A., Sigurdsson, Jon K., Juliusson, Kristinn, Bjarnadottir, Kristbjörg, Sigurbjornsdottir, Sara, Jonsson, Stefan, Norland, Kristjan, Stefansdottir, Lilja, Sigurdsson, Asgeir, Sveinbjornsson, Gardar, Oddsson, Asmundur, Bjornsdottir, Gyda, Gudmundsson, Reynir L., Halldorsson, Gisli H., Rafnar, Thorunn, Jonsdottir, Ingileif, Steingrimsson, Eirikur, Norddahl, Gudmundur L., Masson, Gisli, Sulem, Patrick, Jonsson, Helgi, Ingvarsson, Thorvaldur, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, and Stefansson, Kari
- Published
- 2018
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24. Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis
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Oskarsson, Gudjon R., Oddsson, Asmundur, Magnusson, Magnus K., Kristjansson, Ragnar P., Halldorsson, Gisli H., Ferkingstad, Egil, Zink, Florian, Helgadottir, Anna, Ivarsdottir, Erna V., Arnadottir, Gudny A., Jensson, Brynjar O., Katrinardottir, Hildigunnur, Sveinbjornsson, Gardar, Kristinsdottir, Anna M., Lee, Amy L., Saemundsdottir, Jona, Stefansdottir, Lilja, Sigurdsson, Jon K., Davidsson, Olafur B., Benonisdottir, Stefania, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Jonsson, Stefan, Gudmundsson, Reynir L., Asselbergs, Folkert W., Tragante, Vinicius, Gunnarsson, Bjarni, Masson, Gisli, Thorleifsson, Gudmar, Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T., Gudbjartsson, Daniel F., Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
- Published
- 2020
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25. Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
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Zink, Florian, Stacey, Simon N., Norddahl, Gudmundur L., Frigge, Michael L., Magnusson, Olafur T., Jonsdottir, Ingileif, Thorgeirsson, Thorgeir E., Sigurdsson, Asgeir, Gudjonsson, Sigurjon A., Gudmundsson, Julius, Jonasson, Jon G., Tryggvadottir, Laufey, Jonsson, Thorvaldur, Helgason, Agnar, Gylfason, Arnaldur, Sulem, Patrick, Rafnar, Thorunn, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Masson, Gisli, Kong, Augustine, and Stefansson, Kari
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- 2017
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26. A Lentiviral Fluorescent Genetic Barcoding System for Flow Cytometry-Based Multiplex Tracking
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Maetzig, Tobias, Ruschmann, Jens, Lai, Courteney K., Ngom, Mor, Imren, Suzan, Rosten, Patricia, Norddahl, Gudmundur L., von Krosigk, Niklas, Sanchez Milde, Lea, May, Christopher, Selich, Anton, Rothe, Michael, Dhillon, Ishpreet, Schambach, Axel, and Humphries, R. Keith
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- 2017
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27. Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
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Olafsdottir, Thorunn A., Theodors, Fannar, Bjarnadottir, Kristbjorg, Bjornsdottir, Unnur Steina, Agustsdottir, Arna B., Stefansson, Olafur A., Ivarsdottir, Erna V., Sigurdsson, Jon K., Benonisdottir, Stefania, Eyjolfsson, Gudmundur I., Gislason, David, Gislason, Thorarinn, Guðmundsdóttir, Steinunn, Gylfason, Arnaldur, Halldorsson, Bjarni V., Halldorsson, Gisli H., Juliusdottir, Thorhildur, Kristinsdottir, Anna M., Ludviksdottir, Dora, Ludviksson, Bjorn R., Masson, Gisli, Norland, Kristjan, Onundarson, Pall T., Olafsson, Isleifur, Sigurdardottir, Olof, Stefansdottir, Lilja, Sveinbjornsson, Gardar, Tragante, Vinicius, Gudbjartsson, Daniel F., Thorleifsson, Gudmar, Sulem, Patrick, Thorsteinsdottir, Unnur, Norddahl, Gudmundur L., Jonsdottir, Ingileif, and Stefansson, Kari
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- 2020
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28. GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
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Pabst, Caroline, Bergeron, Anne, Lavallée, Vincent-Philippe, Yeh, Jonathan, Gendron, Patrick, Norddahl, Gudmundur L., Krosl, Jana, Boivin, Isabel, Deneault, Eric, Simard, Jessica, Imren, Suzan, Boucher, Geneviève, Eppert, Kolja, Herold, Tobias, Bohlander, Stefan K., Humphries, Keith, Lemieux, Sébastien, Hébert, Josée, Sauvageau, Guy, and Barabé, Frédéric
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- 2016
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29. Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
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Styrkarsdottir, Unnur, Stefansson, Olafur A., Gunnarsdottir, Kristbjorg, Thorleifsson, Gudmar, Lund, Sigrun H., Stefansdottir, Lilja, Juliusson, Kristinn, Agustsdottir, Arna B., Zink, Florian, Halldorsson, Gisli H., Ivarsdottir, Erna V., Benonisdottir, Stefania, Jonsson, Hakon, Gylfason, Arnaldur, Norland, Kristjan, Trajanoska, Katerina, Boer, Cindy G., Southam, Lorraine, Leung, Jason C. S., Tang, Nelson L. S., Kwok, Timothy C. Y., Lee, Jenny S. W., Ho, Suzanne C., Byrjalsen, Inger, Center, Jacqueline R., Lee, Seung Hun, Koh, Jung-Min, Lohmander, L. Stefan, Ho-Pham, Lan T., Nguyen, Tuan V., Eisman, John A., Woo, Jean, Leung, Ping-C., Loughlin, John, Zeggini, Eleftheria, Christiansen, Claus, Rivadeneira, Fernando, van Meurs, Joyce, Uitterlinden, Andre G., Mogensen, Brynjolfur, Jonsson, Helgi, Ingvarsson, Thorvaldur, Sigurdsson, Gunnar, Benediktsson, Rafn, Sulem, Patrick, Jonsdottir, Ingileif, Masson, Gisli, Holm, Hilma, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., and Stefansson, Kari
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- 2019
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30. GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
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Styrkarsdottir, Unnur, Stefansson, Olafur A., Gunnarsdottir, Kristbjorg, Thorleifsson, Gudmar, Lund, Sigrun H., Stefansdottir, Lilja, Juliusson, Kristinn, Agustsdottir, Arna B., Zink, Florian, Halldorsson, Gisli H., Ivarsdottir, Erna V., Benonisdottir, Stefania, Jonsson, Hakon, Gylfason, Arnaldur, Norland, Kristjan, Trajanoska, Katerina, Boer, Cindy G., Southam, Lorraine, Leung, Jason C. S., Tang, Nelson L. S., Kwok, Timothy C. Y., Lee, Jenny S. W., Ho, Suzanne C., Byrjalsen, Inger, Center, Jacqueline R., Lee, Seung Hun, Koh, Jung-Min, Lohmander, L. Stefan, Ho-Pham, Lan T., Nguyen, Tuan V., Eisman, John A., Woo, Jean, Leung, Ping-C., Loughlin, John, Zeggini, Eleftheria, Christiansen, Claus, Rivadeneira, Fernando, van Meurs, Joyce, Uitterlinden, Andre G., Mogensen, Brynjolfur, Jonsson, Helgi, Ingvarsson, Thorvaldur, Sigurdsson, Gunnar, Benediktsson, Rafn, Sulem, Patrick, Jonsdottir, Ingileif, Masson, Gisli, Holm, Hilma, Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., and Stefansson, Kari
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- 2019
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31. A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy
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Bjornsdottir, Gyda, Ivarsdottir, Erna V., Bjarnadottir, Kristbjorg, Benonisdottir, Stefania, Gylfadottir, Sandra Sif, Arnadottir, Gudny A., Benediktsson, Rafn, Halldorsson, Gisli Hreinn, Helgadottir, Anna, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Jonsdottir, Ingileif, Kristinsdottir, Anna Margret, Magnusson, Olafur Th., Masson, Gisli, Melsted, Pall, Rafnar, Thorunn, Sigurdsson, Asgeir, Sigurdsson, Gunnar, Skuladottir, Astros, Steinthorsdottir, Valgerdur, Styrkarsdottir, Unnur, Thorgeirsson, Gudmundur, Thorleifsson, Gudmar, Vikingsson, Arnor, Gudbjartsson, Daniel F., Holm, Hilma, Stefansson, Hreinn, Thorsteinsdottir, Unnur, Norddahl, Gudmundur L., Sulem, Patrick, Thorgeirsson, Thorgeir E., and Stefansson, Kari
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- 2019
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32. Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
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Ferkingstad, Egil, Oddsson, Asmundur, Gretarsdottir, Solveig, Benonisdottir, Stefania, Thorleifsson, Gudmar, Deaton, Aimee M., Jonsson, Stefan, Stefansson, Olafur A., Norddahl, Gudmundur L., Zink, Florian, Arnadottir, Gudny A., Gunnarsson, Bjarni, Halldorsson, Gisli H., Helgadottir, Anna, Jensson, Brynjar O., Kristjansson, Ragnar P., Sveinbjornsson, Gardar, Sverrisson, David A., Masson, Gisli, Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Holm, Hilma, Jonsdottir, Ingileif, Olafsson, Sigurdur, Steingrimsdottir, Thora, Rafnar, Thorunn, Bjornsson, Einar S., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, and Stefansson, Kari
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- 2018
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33. A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease
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Arnadottir, Gudny A., Norddahl, Gudmundur L., Gudmundsdottir, Steinunn, Agustsdottir, Arna B., Sigurdsson, Snaevar, Jensson, Brynjar O., Bjarnadottir, Kristbjorg, Theodors, Fannar, Benonisdottir, Stefania, Ivarsdottir, Erna V., Oddsson, Asmundur, Kristjansson, Ragnar P., Sulem, Gerald, Alexandersson, Kristjan F., Juliusdottir, Thorhildur, Gudmundsson, Kjartan R., Saemundsdottir, Jona, Jonasdottir, Adalbjorg, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Manzanillo, Paolo, Gudjonsson, Sigurjon A., Thorisson, Gudmundur A., Magnusson, Olafur Th., Masson, Gisli, Orvar, Kjartan B., Holm, Hilma, Bjornsson, Sigurdur, Arngrimsson, Reynir, Gudbjartsson, Daniel F., Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Haraldsson, Asgeir, Sulem, Patrick, and Stefansson, Kari
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- 2018
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34. A truncating mutation in EPOR leads to hypo-responsiveness to erythropoietin with normal haemoglobin
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Oskarsson, Gudjon R., Kristjansson, Ragnar P., Lee, Amy L., Sveinbjornsson, Gardar, Magnusson, Magnus K., Ivarsdottir, Erna V., Benonisdottir, Stefania, Oddsson, Asmundur, Davidsson, Olafur B., Saemundsdottir, Jona, Halldorsson, Gisli H., Arthur, Joseph, Arnadottir, Gudny A., Masson, Gisli, Jensson, Brynjar O., Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T., Gudbjartsson, Daniel F., Norddahl, Gudmundur L., Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
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- 2018
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35. A rare missense variant in NR1H4 associates with lower cholesterol levels
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Deaton, Aimee M., Sulem, Patrick, Nioi, Paul, Benonisdottir, Stefania, Ward, Lucas D., Davidsson, Olafur B., Lao, Socheata, Helgadottir, Anna, Fan, Fan, Jensson, Brynjar O., Norddahl, Gudmundur L., Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Sigurdsson, Asgeir, Kristjansson, Ragnar P., Oddsson, Asmundur, Arnadottir, Gudny A., Jonsson, Hakon, Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Bjornsson, Einar S., Olafsson, Sigurdur, Steingrimsdottir, Thora, Rafnar, Thorunn, Thorgeirsson, Gudmundur, Masson, Gisli, Thorleifsson, Gudmar, Gudbjartsson, Daniel F., Holm, Hilma, Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2018
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36. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
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Wahlestedt, Martin, Norddahl, Gudmundur L., Sten, Gerd, Ugale, Amol, Frisk, Mary-Ann Micha, Mattsson, Ragnar, Deierborg, Tomas, Sigvardsson, Mikael, and Bryder, David
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- 2013
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37. Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease
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Nioi, Paul, Sigurdsson, Asgeir, Thorleifsson, Gudmar, Helgason, Hannes, Agustsdottir, Arna B., Norddahl, Gudmundur L., Helgadottir, Anna, Magnusdottir, Audur, Jonasdottir, Aslaug, Gretarsdottir, Solveig, Jonsdottir, Ingileif, Steinthorsdottir, Valgerdur, Rafnar, Thorunn, Swinkels, Dorine W., Galesloot, Tessel E., Grarup, Niels, Jørgensen, Torben, Vestergaard, Henrik, Hansen, Torben, Lauritzen, Torsten, Linneberg, Allan, Friedrich, Nele, Krarup, Nikolaj T., Fenger, Mogens, Abildgaard, Ulrik, Hansen, Peter R., Galløe, Anders M., Braund, Peter S., Nelson, Christopher P., Hall, Alistair S., Williams, Michael J.A., van Rij, Andre M., Jones, Gregory T., Patel, Riyaz S., Levey, Allan I., Hayek, Salim, Shah, Svati H., Reilly, Muredach, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Olafsson, Isleifur, Kiemeney, Lambertus A., Quyyumi, Arshed A., Rader, Daniel J., Kraus, William E., Samani, Nilesh J., Pedersen, Oluf, Thorgeirsson, Gudmundur, Masson, Gisli, Holm, Hilma, Gudbjartsson, Daniel, Sulem, Patrick, Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2016
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38. Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset
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Saevarsdottir, Saedis, Stefansdottir, Lilja, Sulem, Patrick, Thorleifsson, Gudmar, Ferkingstad, Egil, Rutsdottir, Gudrun, Glintborg, Bente, Westerlind, Helga, Grondal, Gerdur, Loft, Isabella C., Sorensen, Signe Bek, Lie, Benedicte A., Brink, Mikael, Arlestig, Lisbeth, Arnthorsson, Asgeir Orn, Baecklund, Eva, Banasik, Karina, Bank, Steffen, Bjorkman, Lena I, Ellingsen, Torkell, Erikstrup, Christian, Frei, Oleksandr, Gjertsson, Inger, Gudbjartsson, Daniel F., Gudjonsson, Sigurjon A., Halldorsson, Gisli H., Hendricks, Oliver, Hillert, Jan, Hogdall, Estrid, Jacobsen, Soren, Jensen, Dorte Vendelbo, Jonsson, Helgi, Kastbom, Alf, Kockum, Ingrid, Kristensen, Salome, Kristjansdottir, Helga, Larsen, Margit H., Linauskas, Asta, Hauge, Ellen-Margrethe, Loft, Anne G., Ludviksson, Bjorn R., Lund, Sigrun H., Markusson, Thorsteinn, Masson, Gisli, Melsted, Pall, Moore, Kristjan H. S., Munk, Heidi, Nielsen, Kaspar R., Norddahl, Gudmundur L., Oddsson, Asmundur, Olafsdottir, Thorunn A., Olason, Pall I, Olsson, Tomas, Ostrowski, Sisse Rye, Horslev-Petersen, Kim, Rognvaldsson, Solvi, Sanner, Helga, Silberberg, Gilad N., Stefansson, Hreinn, Sorensen, Erik, Sorensen, Inge J., Turesson, Carl, Bergman, Thomas, Alfredsson, Lars, Kvien, Tore K., Brunak, Soren, Steinsson, Kristjan, Andersen, Vibeke, Andreassen, Ole A., Rantapaa-Dahlqvist, Solbritt, Hetland, Merete Lund, Klareskog, Lars, Askling, Johan, Padyukov, Leonid, Pedersen, Ole Bv, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, Stefansson, Kari, Saevarsdottir, Saedis, Stefansdottir, Lilja, Sulem, Patrick, Thorleifsson, Gudmar, Ferkingstad, Egil, Rutsdottir, Gudrun, Glintborg, Bente, Westerlind, Helga, Grondal, Gerdur, Loft, Isabella C., Sorensen, Signe Bek, Lie, Benedicte A., Brink, Mikael, Arlestig, Lisbeth, Arnthorsson, Asgeir Orn, Baecklund, Eva, Banasik, Karina, Bank, Steffen, Bjorkman, Lena I, Ellingsen, Torkell, Erikstrup, Christian, Frei, Oleksandr, Gjertsson, Inger, Gudbjartsson, Daniel F., Gudjonsson, Sigurjon A., Halldorsson, Gisli H., Hendricks, Oliver, Hillert, Jan, Hogdall, Estrid, Jacobsen, Soren, Jensen, Dorte Vendelbo, Jonsson, Helgi, Kastbom, Alf, Kockum, Ingrid, Kristensen, Salome, Kristjansdottir, Helga, Larsen, Margit H., Linauskas, Asta, Hauge, Ellen-Margrethe, Loft, Anne G., Ludviksson, Bjorn R., Lund, Sigrun H., Markusson, Thorsteinn, Masson, Gisli, Melsted, Pall, Moore, Kristjan H. S., Munk, Heidi, Nielsen, Kaspar R., Norddahl, Gudmundur L., Oddsson, Asmundur, Olafsdottir, Thorunn A., Olason, Pall I, Olsson, Tomas, Ostrowski, Sisse Rye, Horslev-Petersen, Kim, Rognvaldsson, Solvi, Sanner, Helga, Silberberg, Gilad N., Stefansson, Hreinn, Sorensen, Erik, Sorensen, Inge J., Turesson, Carl, Bergman, Thomas, Alfredsson, Lars, Kvien, Tore K., Brunak, Soren, Steinsson, Kristjan, Andersen, Vibeke, Andreassen, Ole A., Rantapaa-Dahlqvist, Solbritt, Hetland, Merete Lund, Klareskog, Lars, Askling, Johan, Padyukov, Leonid, Pedersen, Ole Bv, Thorsteinsdottir, Unnur, Jonsdottir, Ingileif, and Stefansson, Kari
- Abstract
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of plasma proteins (SomaScan) and did network analysis (Qiagen). Results We found 25 sequence variants for RA overall, 33 for seropositive and 2 for seronegative RA, altogether 37 sequence variants at 34 non-HLA loci, of which 15 are novel. Genomic, transcriptomic and proteomic analysis of these yielded 25 causal genes in seropositive RA and additional two overall. Most encode proteins in the network of interferon-alpha/beta and IL-12/23 that signal through the JAK/STAT-pathway. Highlighting those with largest effect on seropositive RA, a rare missense variant in STAT4 (rs140675301-A) that is independent of reported non-coding STAT4-variants, increases the risk of seropositive RA 2.27-fold (p=2.1x10(-9)), more than the rs2476601-A missense variant in PTPN22 (OR=1.59, p=1.3x10(-160)). STAT4 rs140675301-A replaces hydrophilic glutamic acid with hydrophobic valine (Glu128Val) in a conserved, surface-exposed loop. A stop-mutation (rs76428106-C) in FLT3 increases seropositive RA risk (OR=1.35, p=6.6x10(-11)). Independent missense variants in TYK2 (rs34536443-C, rs12720356-C, rs35018800-A, latter two novel) associate with decreased risk of seropositive RA (ORs=0.63-0.87, p=10(-9)-10(-27)) and decreased plasma levels of interferon-alpha/beta receptor 1 that signals through TYK2/JAK1/STAT4. Conclusion Sequence variants pointing to causal genes in the JAK/STAT pathway have largest effect on seropositive RA, while associations with seronegative RA remain scarce., Funding Agencies|NORDFORSK [90825]; Swedish Research Council [2018-02803]; Swedish innovation Agency (Vinnova); Innovationsfonden; The Research Council of Norway; Region Stockholm-Karolinska Institutet; Region Vasterbotten (ALF); Danish Rheumatism Association [R194-A6956, A1923, A3037, A3570]; Swedish Brain Foundation; Nils and Bibbi Jensens Foundation; Knut and Alice Wallenberg Foundation; Margaretha af Ugglas Foundation; South-Eastern Heath Region of Norway; Health Research Fund of Central Denmark Region; Region of Southern Denmark; A.P. Moller Foundation for the Advancement of Medical Science; Colitis-Crohn Foreningen; Novo Nordisk Foundation [NNF15OC0016932]; Aase og Ejnar Danielsens Fond; Beckett-Fonden; Augustinus Fonden; Knud and Edith Eriksens Mindefond; Laege Sofus Carl Emil Friis and Hustru Olga Doris Friis Legat; Psoriasis Forskningsfonden; University of Aarhus; Region of Southern Denmarks PhD Fund [12/7725]; Department of Rheumatology, Frederiksberg Hospital; Research Council of Norway [229624, 223273]; South East and Western Norway Health Authorities; ERC AdG project SELECTionPREDISPOSED; Stiftelsen Kristian Gerhard Jebsen; Trond Mohn Foundation; Novo Nordisk Foundation; University of Bergen
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- 2022
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39. Effect of booster vaccination against Delta and Omicron variants in Iceland
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Norddahl, Gudmundur L, primary, Melsted, Pall, additional, Gunnarsdottir, Kristbjorg, additional, Halldorsson, Gisli H, additional, Olafsdottir, Thorunn A, additional, Gylfason, Arnaldur, additional, Kristjansson, Mar, additional, Magnusson, Olafur T, additional, Sulem, Patrick, additional, Gudbjartsson, Daniel F, additional, Thorsteinsdottir, Unnur, additional, Jonsdottir, Ingileif, additional, and Stefansson, Kari, additional
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- 2022
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40. Large-scale comparison of immunoassay- and aptamer-based plasma proteomics through genetics and disease
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Hjorleifsson Eldjarn, Grimur, primary, Ferkingstad, Egil, additional, Lund, Sigrun H., additional, Helgason, Hannes, additional, Magnusson, Olafur Th., additional, Olafsdottir, Thorunn A., additional, Halldorsson, Bjarni V., additional, Olason, Pall I., additional, Zink, Florian, additional, Gudjonsson, Sigurjon A., additional, Sveinbjornsson, Gardar, additional, Magnusson, Magnus I., additional, Helgason, Agnar, additional, Oddsson, Asmundur, additional, Halldorsson, Gisli H., additional, Magnusson, Magnus K., additional, Saevarsdottir, Saedis, additional, Eiriksdottir, Thjodbjorg, additional, Masson, Gisli, additional, Stefansson, Hreinn, additional, Jonsdottir, Ingileif, additional, Holm, Hilma, additional, Rafnar, Thorunn, additional, Melsted, Pall, additional, Saemundsdottir, Jona, additional, Norddahl, Gudmundur L., additional, Thorleifsson, Gudmar, additional, Ulfarsson, Magnus O., additional, Gudbjartsson, Daniel F., additional, Thorsteinsdottir, Unnur, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
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- 2022
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41. The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland
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Styrkarsdottir, Unnur, primary, Lund, Sigrun H., additional, Saevarsdottir, Saedis, additional, Magnusson, Magnus I., additional, Gunnarsdottir, Kristbjorg, additional, Norddahl, Gudmundur L., additional, Frigge, Michael L., additional, Ivarsdottir, Erna V., additional, Bjornsdottir, Gyda, additional, Holm, Hilma, additional, Thorgeirsson, Gudmundur, additional, Rafnar, Thorunn, additional, Jonsdottir, Ingileif, additional, Ingvarsson, Thorvaldur, additional, Jonsson, Helgi, additional, Sulem, Patrick, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel, additional, and Stefansson, Kari, additional
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- 2021
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42. Reconstruction of a large-scale outbreak of SARS-CoV-2 infection in Iceland informs vaccination strategies
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Hjorleifsson, Kristjan E, primary, Rognvaldsson, Solvi, additional, Jonsson, Hakon, additional, Agustsdottir, Arna B, additional, Andresdottir, Margret, additional, Birgisdottir, Kolbrun, additional, Eiriksson, Ogmundur, additional, Eythorsson, Elias S, additional, Fridriksdottir, Run, additional, Georgsson, Gudmundur, additional, Gudmundsson, Kjartan R, additional, Gylfason, Arnaldur, additional, Haraldsdottir, Gudbjorg, additional, Jensson, Brynjar O, additional, Jonasdottir, Adalbjorg, additional, Jonasdottir, Aslaug, additional, Josefsdottir, Kamilla S, additional, Kristinsdottir, Nina, additional, Kristjansdottir, Borghildur, additional, Kristjansson, Thordur, additional, Magnusdottir, Droplaug N, additional, Palsson, Runolfur, additional, Roux, Louise le, additional, Sigurbergsdottir, Gudrun M, additional, Sigurdsson, Asgeir, additional, Sigurdsson, Martin I, additional, Sveinbjornsson, Gardar, additional, Thorarensen, Emil Aron, additional, Thorbjornsson, Bjarni, additional, Thordardottir, Marianna, additional, Helgason, Agnar, additional, Holm, Hilma, additional, Jonsdottir, Ingileif, additional, Jonsson, Frosti, additional, Magnusson, Olafur T, additional, Masson, Gisli, additional, Norddahl, Gudmundur L, additional, Saemundsdottir, Jona, additional, Sulem, Patrick, additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, Melsted, Pall, additional, and Stefansson, Kari, additional
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- 2021
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43. Genetic insight into sick sinus syndrome
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Thorolfsdottir, Rosa B, Sveinbjornsson, Gardar, Aegisdottir, Hildur M, Benonisdottir, Stefania, Stefansdottir, Lilja, Ivarsdottir, Erna V, Halldorsson, Gisli H, Sigurdsson, Jon K, Torp-Pedersen, Christian, Weeke, Peter E, Brunak, Søren, Westergaard, David, Pedersen, Ole B., Sørensen, Erik, Nielsen, Kaspar R, Burgdorf, Kristoffer S., Banasik, Karina, Brumpton, Ben, Zhou, Wei, Oddsson, Asmundur, Tragante, Vinicius, Hjorleifsson, Kristjan E, Davidsson, Olafur B, Rajamani, Sridharan, Jonsson, Stefan, Torfason, Bjarni, Valgardsson, Atli S, Thorgeirsson, Gudmundur, Frigge, Michael L, Thorleifsson, Gudmar, Norddahl, Gudmundur L, Helgadottir, Anna, Gretarsdottir, Solveig, Sulem, Patrick, Jonsdottir, Ingileif, Willer, Cristen J, Hveem, Kristian, Bundgaard, Henning, Ullum, Henrik, Arnar, David O, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, Stefansson, Kari, Thorolfsdottir, Rosa B, Sveinbjornsson, Gardar, Aegisdottir, Hildur M, Benonisdottir, Stefania, Stefansdottir, Lilja, Ivarsdottir, Erna V, Halldorsson, Gisli H, Sigurdsson, Jon K, Torp-Pedersen, Christian, Weeke, Peter E, Brunak, Søren, Westergaard, David, Pedersen, Ole B., Sørensen, Erik, Nielsen, Kaspar R, Burgdorf, Kristoffer S., Banasik, Karina, Brumpton, Ben, Zhou, Wei, Oddsson, Asmundur, Tragante, Vinicius, Hjorleifsson, Kristjan E, Davidsson, Olafur B, Rajamani, Sridharan, Jonsson, Stefan, Torfason, Bjarni, Valgardsson, Atli S, Thorgeirsson, Gudmundur, Frigge, Michael L, Thorleifsson, Gudmar, Norddahl, Gudmundur L, Helgadottir, Anna, Gretarsdottir, Solveig, Sulem, Patrick, Jonsdottir, Ingileif, Willer, Cristen J, Hveem, Kristian, Bundgaard, Henning, Ullum, Henrik, Arnar, David O, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F, Holm, Hilma, and Stefansson, Kari
- Abstract
AIMS: The aim of this study was to use human genetics to investigate the pathogenesis of sick sinus syndrome (SSS) and the role of risk factors in its development.METHODS AND RESULTS: We performed a genome-wide association study of 6469 SSS cases and 1 000 187 controls from deCODE genetics, the Copenhagen Hospital Biobank, UK Biobank, and the HUNT study. Variants at six loci associated with SSS, a reported missense variant in MYH6, known atrial fibrillation (AF)/electrocardiogram variants at PITX2, ZFHX3, TTN/CCDC141, and SCN10A and a low-frequency (MAF = 1.1-1.8%) missense variant, p.Gly62Cys in KRT8 encoding the intermediate filament protein keratin 8. A full genotypic model best described the p.Gly62Cys association (P = 1.6 × 10-20), with an odds ratio (OR) of 1.44 for heterozygotes and a disproportionally large OR of 13.99 for homozygotes. All the SSS variants increased the risk of pacemaker implantation. Their association with AF varied and p.Gly62Cys was the only variant not associating with any other arrhythmia or cardiovascular disease. We tested 17 exposure phenotypes in polygenic score (PGS) and Mendelian randomization analyses. Only two associated with the risk of SSS in Mendelian randomization, AF, and lower heart rate, suggesting causality. Powerful PGS analyses provided convincing evidence against causal associations for body mass index, cholesterol, triglycerides, and type 2 diabetes (P > 0.05).CONCLUSION: We report the associations of variants at six loci with SSS, including a missense variant in KRT8 that confers high risk in homozygotes and points to a mechanism specific to SSS development. Mendelian randomization supports a causal role for AF in the development of SSS.
- Published
- 2021
44. Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis
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Team Medisch, Circulatory Health, Onderzoek Precision medicine, Oskarsson, Gudjon R, Oddsson, Asmundur, Magnusson, Magnus K, Kristjansson, Ragnar P, Halldorsson, Gisli H, Ferkingstad, Egil, Zink, Florian, Helgadottir, Anna, Ivarsdottir, Erna V, Arnadottir, Gudny A, Jensson, Brynjar O, Katrinardottir, Hildigunnur, Sveinbjornsson, Gardar, Kristinsdottir, Anna M, Lee, Amy L, Saemundsdottir, Jona, Stefansdottir, Lilja, Sigurdsson, Jon K, Davidsson, Olafur B, Benonisdottir, Stefania, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Jonsson, Stefan, Gudmundsson, Reynir L, Asselbergs, Folkert W, Tragante, Vinicius, Gunnarsson, Bjarni, Masson, Gisli, Thorleifsson, Gudmar, Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T, Gudbjartsson, Daniel F, Norddahl, Gudmundur L, Thorsteinsdottir, Unnur, Sulem, Patrick, Stefansson, Kari, Team Medisch, Circulatory Health, Onderzoek Precision medicine, Oskarsson, Gudjon R, Oddsson, Asmundur, Magnusson, Magnus K, Kristjansson, Ragnar P, Halldorsson, Gisli H, Ferkingstad, Egil, Zink, Florian, Helgadottir, Anna, Ivarsdottir, Erna V, Arnadottir, Gudny A, Jensson, Brynjar O, Katrinardottir, Hildigunnur, Sveinbjornsson, Gardar, Kristinsdottir, Anna M, Lee, Amy L, Saemundsdottir, Jona, Stefansdottir, Lilja, Sigurdsson, Jon K, Davidsson, Olafur B, Benonisdottir, Stefania, Jonasdottir, Aslaug, Jonasdottir, Adalbjorg, Jonsson, Stefan, Gudmundsson, Reynir L, Asselbergs, Folkert W, Tragante, Vinicius, Gunnarsson, Bjarni, Masson, Gisli, Thorleifsson, Gudmar, Rafnar, Thorunn, Holm, Hilma, Olafsson, Isleifur, Onundarson, Pall T, Gudbjartsson, Daniel F, Norddahl, Gudmundur L, Thorsteinsdottir, Unnur, Sulem, Patrick, and Stefansson, Kari
- Published
- 2020
45. Lifelong Reduction in LDL (Low-Density Lipoprotein) Cholesterol due to a Gain-of-Function Mutation in LDLR
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Bjornsson, Eythor, primary, Gunnarsdottir, Kristbjorg, additional, Halldorsson, Gisli H., additional, Sigurdsson, Asgeir, additional, Arnadottir, Gudny A., additional, Jonsson, Hakon, additional, Olafsdottir, Eva F., additional, Niehus, Sebastian, additional, Kehr, Birte, additional, Sveinbjörnsson, Gardar, additional, Gudmundsdottir, Steinunn, additional, Helgadottir, Anna, additional, Andersen, Karl, additional, Thorleifsson, Gudmar, additional, Eyjolfsson, Gudmundur I., additional, Olafsson, Isleifur, additional, Sigurdardottir, Olof, additional, Saemundsdottir, Jona, additional, Jonsdottir, Ingileif, additional, Magnusson, Olafur Th., additional, Masson, Gisli, additional, Stefansson, Hreinn, additional, Gudbjartsson, Daniel F., additional, Thorgeirsson, Gudmundur, additional, Holm, Hilma, additional, Halldorsson, Bjarni V., additional, Melsted, Pall, additional, Norddahl, Gudmundur L., additional, Sulem, Patrick, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2021
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46. Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming
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Gisladottir, Rosa S., primary, Ivarsdottir, Erna V., additional, Helgason, Agnar, additional, Jonsson, Lina, additional, Hannesdottir, Nanna K., additional, Rutsdottir, Gudrun, additional, Arnadottir, Gudny A., additional, Skuladottir, Astros, additional, Jonsson, Benedikt A., additional, Norddahl, Gudmundur L., additional, Ulfarsson, Magnus O., additional, Helgason, Hannes, additional, Halldorsson, Bjarni V., additional, Nawaz, Muhammad S., additional, Tragante, Vinicius, additional, Sveinbjornsson, Gardar, additional, Thorgeirsson, Thorgeir, additional, Oddsson, Asmundur, additional, Kristjansson, Ragnar P., additional, Bjornsdottir, Gyda, additional, Thorgeirsson, Gudmundur, additional, Jonsdottir, Ingileif, additional, Holm, Hilma, additional, Gudbjartsson, Daniel F., additional, Thorsteinsdottir, Unnur, additional, Stefansson, Hreinn, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
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- 2020
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47. Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function
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Norddahl, Gudmundur L., Wahlestedt, Martin, Gisler, Santiago, Sigvardsson, Mikael, and Bryder, David
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- 2012
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48. Humoral Immune Response to SARS-CoV-2 in Iceland
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Gudbjartsson, Daniel F., primary, Norddahl, Gudmundur L., additional, Melsted, Pall, additional, Gunnarsdottir, Kristbjorg, additional, Holm, Hilma, additional, Eythorsson, Elias, additional, Arnthorsson, Asgeir O., additional, Helgason, Dadi, additional, Bjarnadottir, Kristbjorg, additional, Ingvarsson, Ragnar F., additional, Thorsteinsdottir, Brynja, additional, Kristjansdottir, Steinunn, additional, Birgisdottir, Kolbrun, additional, Kristinsdottir, Anna M., additional, Sigurdsson, Martin I., additional, Arnadottir, Gudny A., additional, Ivarsdottir, Erna V., additional, Andresdottir, Margret, additional, Jonsson, Frosti, additional, Agustsdottir, Arna B., additional, Berglund, Jonas, additional, Eiriksdottir, Berglind, additional, Fridriksdottir, Run, additional, Gardarsdottir, Elisabet E., additional, Gottfredsson, Magnus, additional, Gretarsdottir, Olafia S., additional, Gudmundsdottir, Steinunn, additional, Gudmundsson, Kjartan R., additional, Gunnarsdottir, Thora R., additional, Gylfason, Arnaldur, additional, Helgason, Agnar, additional, Jensson, Brynjar O., additional, Jonasdottir, Aslaug, additional, Jonsson, Hakon, additional, Kristjansson, Thordur, additional, Kristinsson, Karl G., additional, Magnusdottir, Droplaug N., additional, Magnusson, Olafur T., additional, Olafsdottir, Lovisa B., additional, Rognvaldsson, Solvi, additional, le Roux, Louise, additional, Sigmundsdottir, Gudrun, additional, Sigurdsson, Asgeir, additional, Sveinbjornsson, Gardar, additional, Sveinsdottir, Kristin E., additional, Sveinsdottir, Maney, additional, Thorarensen, Emil A., additional, Thorbjornsson, Bjarni, additional, Thordardottir, Marianna, additional, Saemundsdottir, Jona, additional, Kristjansson, S. Hjortur, additional, Josefsdottir, Kamilla S., additional, Masson, Gisli, additional, Georgsson, Gudmundur, additional, Kristjansson, Mar, additional, Moller, Alma, additional, Palsson, Runolfur, additional, Gudnason, Thorolfur, additional, Thorsteinsdottir, Unnur, additional, Jonsdottir, Ingileif, additional, Sulem, Patrick, additional, and Stefansson, Kari, additional
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- 2020
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49. Spread of SARS-CoV-2 in the Icelandic Population
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Gudbjartsson, Daniel F., primary, Helgason, Agnar, additional, Jonsson, Hakon, additional, Magnusson, Olafur T., additional, Melsted, Pall, additional, Norddahl, Gudmundur L., additional, Saemundsdottir, Jona, additional, Sigurdsson, Asgeir, additional, Sulem, Patrick, additional, Agustsdottir, Arna B., additional, Eiriksdottir, Berglind, additional, Fridriksdottir, Run, additional, Gardarsdottir, Elisabet E., additional, Georgsson, Gudmundur, additional, Gretarsdottir, Olafia S., additional, Gudmundsson, Kjartan R., additional, Gunnarsdottir, Thora R., additional, Gylfason, Arnaldur, additional, Holm, Hilma, additional, Jensson, Brynjar O., additional, Jonasdottir, Aslaug, additional, Jonsson, Frosti, additional, Josefsdottir, Kamilla S., additional, Kristjansson, Thordur, additional, Magnusdottir, Droplaug N., additional, le Roux, Louise, additional, Sigmundsdottir, Gudrun, additional, Sveinbjornsson, Gardar, additional, Sveinsdottir, Kristin E., additional, Sveinsdottir, Maney, additional, Thorarensen, Emil A., additional, Thorbjornsson, Bjarni, additional, Löve, Arthur, additional, Masson, Gisli, additional, Jonsdottir, Ingileif, additional, Möller, Alma D., additional, Gudnason, Thorolfur, additional, Kristinsson, Karl G., additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
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- 2020
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50. Early Spread of SARS-Cov-2 in the Icelandic Population
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Gudbjartsson, Daniel F, primary, Helgason, Agnar, additional, Jonsson, Hakon, additional, Magnusson, Olafur T, additional, Melsted, Pall, additional, Norddahl, Gudmundur L, additional, Saemundsdottir, Jona, additional, Sigurdsson, Asgeir, additional, Sulem, Patrick, additional, Agustsdottir, Arna B, additional, Eiriksdottir, Berglind, additional, Fridriksdottir, Run, additional, Gardarsdottir, Elisabet E, additional, Georgsson, Gudmundur, additional, Gretarsdottir, Olafia S, additional, Gudmundsson, Kjartan R, additional, Gunnarsdottir, Thora R, additional, Gylfason, Arnaldur, additional, Holm, Hilma, additional, Jensson, Brynjar O, additional, Jonasdottir, Aslaug, additional, Jonsson, Frosti, additional, Josefsdottir, Kamilla S, additional, Kristjansson, Thordur, additional, Magnusdottir, Droplaug N, additional, Roux, Louise le, additional, Sigmundsdottir, Gudrun, additional, Sveinbjornsson, Gardar, additional, Sveinsdottir, Kristin E, additional, Sveinsdottir, Maney, additional, Thorarensen, Emil A, additional, Thorbjornsson, Bjarni, additional, Löve, Arthur, additional, Masson, Gisli, additional, Jonsdottir, Ingileif, additional, Moller, Alma, additional, Gudnason, Thorolfur, additional, Kristinsson, Karl G, additional, Thorsteinsdottir, Unnur, additional, and Stefansson, Kari, additional
- Published
- 2020
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