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2. White blood cell subtypes and neutrophil extracellular traps content as biomarkers for stroke etiology in acute ischemic stroke clots retrieved by mechanical thrombectomy

Author

Jabrah, Duaa, Rossi, Rosanna, Molina, Sara, Douglas, Andrew, Pandit, Abhay, McCarthy, Ray, Gilvarry, Michael, Ceder, Eric, Fitzgerald, Seán, Dunker, Dennis, Nordanstig, Annika, Redfors, Petra, Tatlisumak, Turgut, O'Hare, Alan, Power, Sarah, Brennan, Paul, Owens, Peter, Nagy, András, Vadász, Ágnes, De Meyer, Simon F., Tsivgoulis, Georgios, Psychogios, Klearchos, Szikora, Istvan, Jood, Katarina, Rentzos, Alexandros, Thornton, John, and Doyle, Karen

Published
2024
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4. Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes

Author

Strambo, Davide, Marto, João Pedro, Ntaios, George, Nguyen, Thanh N., Michel, Patrik, Herzig, Roman, Członkowksa, Anna, Demeestere, Jelle, Yassin Mansour, Ossama, Georgiopoulos, Georgios, Nogueira, Raul G., Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Nuno Ramos, João, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Paiva-Nunes, Ana, Ferreira, Patrícia, Pinho-e-Melo, Teresa, Carvalho-Dias, Mariana, Paula, André, Alberto Correia, Manuel, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Nuno-Alves, José, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araújo, André, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Diamanti, Susanna, Beretta, Simone, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maier, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loic, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Hendrik Schaefer, Jan, Nolte, Christian H., Audebert, Heinrich, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke-Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul J., van-den-Wijngaard, Ido, de Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Pierre Rutgers, Matthieu, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, Gonzalez-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria-Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Pérez-Sánchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Perez de la Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David J., Saxhaug Kristoffersen, Espen, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulík, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Kočí, Lubomír, Eichlová, Zuzana, Jíra, Martin, Kovář, Martin, Panský, Michal, Mencl, Pavel, Paloušková, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Šrámek, Martin, Havlíček, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karliński, Michał, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiącek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielińska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Sławomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Łabuz-Roszak, Beata, Dębiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena-Oana, Radu, Razvan-Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Özcan-Özdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ibrahim Ismail, Ismail, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada-A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenny, Khan, Muhib-A., Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham E., Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz-M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel A., Barrientos, José-Domingo, Caetano, Rayllene, Targa, Rodrigo, Scollo, Sergio, Yalung, Patrick, Nagendra, Shashank, Gaikwad, Abhijit, and Seo, Kwon-Duk

Published
2024
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5. Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults

Author

Jaakonmäki, Nina, Zedde, Marialuisa, Sarkanen, Tomi, Martinez-Majander, Nicolas, Tuohinen, Suvi, Sinisalo, Juha, Ryödi, Essi, Autere, Jaana, Hedman, Marja, Junttola, Ulla, Huhtakangas, Jaana K., Grimaldi, Teresa, Pascarella, Rosario, Nordanstig, Annika, Bech-Hanssen, Odd, Holbe, Christine, Busch, Raila, Fromm, Annette, Ylikotila, Pauli, Turgut, Esme Ekizoglu, Amorim, Isabel, Ryliskiene, Kristina, Tulkki, Lauri, Pascasio, Laura Amaya, Licenik, Radim, Ferdinand, Phillip, Tsivgoulis, Georgios, Jatužis, Dalius, Kõrv, Liisa, Kõrv, Janika, Pezzini, Alessandro, Fonseca, Ana Catarina, Yesilot, Nilufer, Roine, Risto O., Waje-Andreassen, Ulrike, von Sarnowski, Bettina, Redfors, Petra, Huhtakangas, Juha, Numminen, Heikki, Jäkälä, Pekka, and Putaala, Jukka

Published
2022
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6. Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry

Author

Rossi, Rosanna, Molina, Sara, Mereuta, Oana Madalina, Douglas, Andrew, Fitzgerald, Seán, Tierney, Ciara, Pandit, Abhay, Brennan, Paul, Power, Sarah, O’Hare, Alan, Gilvarry, Michael, McCarthy, Ray, Magoufis, Georgios, Tsivgoulis, Georgios, Nagy, András, Vadász, Ágnes, Jood, Katarina, Redfors, Petra, Nordanstig, Annika, Ceder, Erik, Dunker, Dennis, Carlqvist, Jeanette, Psychogios, Klearchos, Szikora, István, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, and Doyle, Karen M.

Published
2022
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7. Characterization of the ‘White’ Appearing Clots that Cause Acute Ischemic Stroke

Author

Mereuta, Oana Madalina, Rossi, Rosanna, Douglas, Andrew, Gil, Sara Molina, Fitzgerald, Seán, Pandit, Abhay, McCarthy, Ray, Gilvarry, Michael, Ceder, Eric, Dunker, Dennis, Nordanstig, Annika, Redfors, Petra, Jood, Katarina, Magoufis, Georgios, Psychogios, Klearchos, Tsivgoulis, Georgios, O'Hare, Alan, Power, Sarah, Brennan, Paul, Nagy, András, Vadász, Ágnes, Brinjikji, Waleed, Kallmes, David F, Szikora, Istvan, Rentzos, Alexandros, Tatlisumak, Turgut, Thornton, John, and Doyle, Karen M.

Published
2021
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8. Association between heavy alcohol consumption and cryptogenic ischaemic stroke in young adults: a case–control study

Author

Martinez-Majander, Nicolas, Kutal, Shakar, Ylikotila, Pauli, Yesilot, Nilufer, Tulkki, Lauri, Zedde, Marialuisa, Sarkanen, Tomi, Junttola, Ulla, Nordanstig, Annika, Fromm, Annette, Ryliskiene, Kristina, Licenik, Radim, Ferdinand, Phillip, Jatuzis, Dalius, Kõrv, Liisa, Kõrv, Janika, Pezzini, Alessandro, Tuohinen, Suvi, Sinisalo, Juha, Lehto, Mika, Gerdts, Eva, Ryo¨di, Essi, Autere, Jaana, Hedman, Marja, Fonseca, Ana Catarina, Waje-Andreassen, Ulrike, von Sarnowski, Bettina, Redfors, Petra, Sairanen, Tiina, Tatlisumak, Turgut, Roine, Risto O, Huhtakangas, Juha, Numminen, Heikki, Ja¨ka¨la¨, Pekka, and Putaala, Jukka

Abstract

BackgroundThe underlying risk factors for young-onset cryptogenic ischaemic stroke (CIS) remain unclear. This multicentre study aimed to explore the association between heavy alcohol consumption and CIS with subgroup analyses stratified by sex and age.MethodsAltogether, 540 patients aged 18–49 years (median age 41; 47.2% women) with a recent CIS and 540 sex-matched and age-matched stroke-free controls were included. Heavy alcohol consumption was defined as >7 (women) and >14 (men) units per week or at least an average of two times per month ≥5 (women) and ≥7 (men) units per instance (binge drinking). A conditional logistic regression adjusting for age, sex, education, hypertension, cardiovascular diseases, diabetes, hypercholesterolaemia, current smoking, obesity, diet and physical inactivity was used to assess the independent association between alcohol consumption and CIS.ResultsPatients were twice as more often heavy alcohol users compared with controls (13.7% vs 6.7%, p<0.001), were more likely to have hypertension and they were more often current smokers, overweight and physically inactive. In the entire study population, heavy alcohol consumption was independently associated with CIS (adjusted OR 2.11; 95% CI 1.22 to 3.63). In sex-specific analysis, heavy alcohol consumption was associated with CIS in men (2.72; 95% CI 1.25 to 5.92), but not in women (1.56; 95% CI 0.71 to 3.41). When exploring the association with binge drinking alone, a significant association was shown in the entire cohort (2.43; 95% CI 1.31 to 4.53) and in men (3.36; 95% CI 1.44 to 7.84), but not in women.ConclusionsHeavy alcohol consumption, particularly binge drinking, appears to be an independent risk factor in young men with CIS.

Published
2025
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9. Large Artery Atherosclerotic Clots are Larger than Clots of other Stroke Etiologies and have Poorer Recanalization rates

Author

Fitzgerald, Seán, Rossi, Rosanna, Mereuta, Oana Madalina, Molina, Sara, Okolo, Adaobi, Douglas, Andrew, Jabrah, Duaa, Pandit, Abhay, McCarthy, Ray, Gilvarry, Michael, Ceder, Erik, Dehlfors, Niclas, Dunker, Dennis, Nordanstig, Annika, Redfors, Petra, Jood, Katarina, Magoufis, Georgios, Psychogios, Klearchos, Tsivgoulis, Georgios, Alderson, Jack, O'Hare, Alan, Power, Sarah, Brennan, Paul, Nagy, András, Vadász, Ágnes, Brinjikji, Waleed, Kallmes, David, Szikora, Istvan, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, and Doyle, Karen M.

Published
2021
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10. Investigating the Role of Brain Natriuretic Peptide (BNP) and N-Terminal-proBNP in Thrombosis and Acute Ischemic Stroke Etiology

Author

Rossi, Rosanna, primary, Jabrah, Duaa, additional, Douglas, Andrew, additional, Prendergast, James, additional, Pandit, Abhay, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Redfors, Petra, additional, Nordanstig, Annika, additional, Tatlisumak, Turgut, additional, Ceder, Erik, additional, Dunker, Dennis, additional, Carlqvist, Jeanette, additional, Szikora, István, additional, Tsivgoulis, Georgios, additional, Psychogios, Klearchos, additional, Thornton, John, additional, Rentzos, Alexandros, additional, Jood, Katarina, additional, Juega, Jesus, additional, and Doyle, Karen M., additional

Published
2024
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11. The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome

Author

Rossi, Rosanna, Fitzgerald, Seán, Molina, Sara, Mereuta, Oana Madalina, Douglas, Andrew, Pandit, Abhay, Santos, Andreia M. Silva, Murphy, Blathnaid, Alderson, Jack, Brennan, Paul, Power, Sarah, O’Hare, Alan, Gilvarry, Michael, McCarthy, Ray, Psychogios, Klearchos, Magoufis, Georgios, Tsivgoulis, Georgios, Nagy, András, Vadász, Ágnes, Szikora, István, Jood, Katarina, Redfors, Petra, Nordanstig, Annika, Ceder, Erik, Dehlfors, Niclas, Dunker, Dennis, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, and Doyle, Karen M.

Published
2021
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12. Tandem occlusions involving the internal carotid and anterior cerebral arteries--A rare form of stroke: Results from the multicenter EVATRISP collaboration study.

Author

Filioglo, Andrei, Simaan, Naaem, Honig, Asaf, Heldner, Mirjam, Pezzini, Alessandro, Martinez-Majander, Nicolas, Padjen, Visnja, Baumgartner, Philipp, Papanagiotou, Panagiotis, Salerno, Alexander, Nolte, Christian, Nordanstig, Annika, Engelter, Stefan, Zini, Andrea, Zedde, Marialuisa, Pedro Marto, João, Arnold, Marcel, Magoni, Mauro, Gensicke, Henrik, and Cohen, Jose

Subjects
ANTERIOR cerebral artery, STROKE, ISCHEMIC stroke, STROKE patients, ENDOVASCULAR surgery
Abstract

Background: Patients with stroke secondary to isolated anterior cerebral artery (ACA) occlusions have poor outcomes. Whether tandemocclusions (TO) of the extracranial internal carotid (ICA) and the ACA carry even worse outcomes that remain unknown. Methods: Patients with TO involving ICA and ACA occlusions were identified from 14 participating centers from the EndoVascular treatment And ThRombolysis in Ischemic Stroke Patients (EVATRISP) project which is a multicenter, observational, cohort study with prospective accrual of data followed by retrospective data analysis. Patients with isolated ACA stroke served as controls. Results: Included were 92 patients with isolated ACA and 16 patients with ICA-ACA TO stroke. On univariate analyses, patients with TO had more severe strokes on admission [median NIHSS (IQR) 13.5 (9-21) vs. 8 (5-12), p = 0.003] and were more often treated with thrombectomy (81 vs. 40%, p = 0.002). Mortality rates were higher among TO patients (31 vs. 11%, p = 0.03). Rates of favorable functional outcomes were numerically lower among TO patients (38 vs. 60%) but the difference was not statistically significant (p = 0.09). On multivariate analyses, the presence of TO did not modify the chances for favorable outcomes. Conclusion: TO stroke with ICA and isolated ACA involvement is rare and results in more severe initial neurological deficits and higher mortality compared to those seen in patients with isolated ACA stroke. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Prevalence and incidence of Carotid-Fetal-Posterior syndrome

Author

Cruz-Rojas, Agneta, Gu, Thomas, Kellomäki, Elisa, Nordanstig, Annika, Fox, Allan J., Johansson, Elias, Cruz-Rojas, Agneta, Gu, Thomas, Kellomäki, Elisa, Nordanstig, Annika, Fox, Allan J., and Johansson, Elias

Abstract

Introduction: Carotid-Fetal-Posterior (CFP) syndrome is a posterior cerebral artery (PCA) territory ischemic stroke/TIA caused by symptomatic >= 50% carotid stenosis or occlusion via fetal posterior communicating artery. We aimed to assess the incidence of CFP syndrome and prevalence of CFP syndrome among symptomatic >= 50% carotid stenosis or occlusion as these are unknown. Methods: We reassessed consecutive CTAs from 4042 persons, and included locally admitted patients with >= 50% carotid stenosis or occlusion. These were assessed for symptoms and signs of possible posterior circulation stroke/TIA (suspicion of CFP syndrome). Among these, those with unilateral PCA territory stroke/TIA, ipsilateral stenosis and fetal/fetal type PCA were considered CFP syndrome. Results: We included 208 locally admitted patients with >= 50% carotid stenosis or occlusion, 33 (16%) patients had suspicion of CFP syndrome, of which 3 (9%) had CFP syndrome. The prevalence of CFP syndrome was 2.9% of symptomatic >= 50% carotid stenosis or occlusion; incidence was 4.23 per 1 000 000 person-years. Also, we found a lower prevalence of CFP-syndrome (0.9%, p=0.047) among referred patients with symptomatic >= 50% carotid stenosis or occlusion than among locally admitted patients with symptomatic >= 50% carotid stenosis or occlusion. Discussion/Conclusion: CFP syndrome has a low incidence and low prevalence among symptomatic carotid stenosis cases. Given lower prevalence of CFP syndrome among referred cases than local, CFP-syndrome seems susceptible to underdiagnosis. On the other hand, few cases with suspicion of CFP syndrome had CFP syndrome, why CFP syndrome also seems susceptible to overdiagnosis if detailed assessment is not employed.

Published
2023
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17. Risk of stroke recurrence after intravenous thrombolysis in patients with symptomatic carotid stenosis

Author

Nordanstig, Annika, Gu, Thomas, Henze, Alexander, Wester, Per, Fox, Allan J., Johansson, Elias, Nordanstig, Annika, Gu, Thomas, Henze, Alexander, Wester, Per, Fox, Allan J., and Johansson, Elias

Abstract

Objective: To assess if intravenous thrombolysis (IVT) affects the risk of recurrent preoperative cerebrovascular events before carotid surgery or stenting in patients with symptomatic ≥ 50% carotid stenosis. Methods: Three cohorts of symptomatic ≥ 50% carotid stenosis patients were merged. To make the control group relevant, we excluded patients not presenting with stroke on the day of symptom onset. The risk of preoperative cerebrovascular events up to 30 days were compared between the IVT-treated and non-IVT-treated. Results: 316 patients were included, 64 (20%) treated with IVT. Those treated with IVT had similar risk of recurrent ipsilateral ischemic stroke or retinal artery occlusion (12% at day 7, 12% at day 30) as those not treated (9% at day 7, 15% at day 30; adjusted HR 0.9, 95%CI 0.4-2.2). There was a tendency (p=0.09) towards time-dependency in the data where the recurrence risk was higher in IVT treated at day 0 (6% in IVT-treated, 1% in non-IVT-treated, OR 5.5, 95%CI 1.2-25.4, p=0.03). This was not significant when adjusting for co-factors (adjusted OR 4.4, 95%CI 0.9-21.8, p=0.07) and was offset by a later risk decrease, with no remaining risk difference between IVT-treated and non-IVT treated at day 7. Conclusions: IVT treatment does not seem to affect the risk of recurrent ipsilateral ischemic stroke in patients with symptomatic ≥ 50% carotid stenosis: The risk is high in both IVT-treated and non-IVT-treated. However, there might be a risk increase on the day of IVT treatment that is offset by a risk decrease during the first week.

Published
2023
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18. Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up

Author

Society of Vascular and Interventional Neurology (US), Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron I., Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, Aguiar de Sousa, Diana, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C. V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Tomazini Martins, Rodrigo, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C. T., Neves, Luciana de Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Silva, Isabelle Lameirinhas da, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Ángel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H, Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Domingo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P. N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M, Rinkel, Leon A., Dippel, Diederik W. J., Dam-Nolen, Dianne H. K. van, Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Pérez-Sánchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T. P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ã-Zcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutiérrez, Santiago, Puri, Ajit S, Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, José Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Nogueira, Raul G., Society of Vascular and Interventional Neurology (US), Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron I., Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, Aguiar de Sousa, Diana, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C. V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Tomazini Martins, Rodrigo, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C. T., Neves, Luciana de Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Silva, Isabelle Lameirinhas da, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Ángel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H, Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Domingo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P. N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M, Rinkel, Leon A., Dippel, Diederik W. J., Dam-Nolen, Dianne H. K. van, Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Pérez-Sánchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T. P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ã-Zcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutiérrez, Santiago, Puri, Ajit S, Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, José Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., and Nogueira, Raul G.

Abstract

Background and Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020)., Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases., Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1–6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1–4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4–5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6–0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31–1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82–2.97], 5,656/195,539) of all stroke hospitalizations., Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year., Trial Registration Information: This study is registered under NCT04934020.

Published
2023

19. Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration

Author

Traenka, Christopher; https://orcid.org/0000-0002-7600-1005, Lorscheider, Johannes; https://orcid.org/0000-0003-1100-2506, Hametner, Christian; https://orcid.org/0000-0002-9955-5430, Baumgartner, Philipp; https://orcid.org/0000-0003-1525-2019, Gralla, Jan; https://orcid.org/0000-0003-1953-9033, Magoni, Mauro, Martinez-Majander, Nicolas; https://orcid.org/0000-0001-8489-7051, Casolla, Barbara, Feil, Katharina, Pascarella, Rosario; https://orcid.org/0000-0002-0512-9298, Papanagiotou, Panagiotis, Nordanstig, Annika; https://orcid.org/0000-0002-3625-2168, Padjen, Visnja, Cereda, Carlo W; https://orcid.org/0000-0002-6479-1476, Psychogios, Marios; https://orcid.org/0000-0002-0016-414X, Nolte, Christian H; https://orcid.org/0000-0001-5577-1775, Zini, Andrea; https://orcid.org/0000-0003-1486-4507, Michel, Patrik; https://orcid.org/0000-0003-4954-7579, Béjot, Yannick; https://orcid.org/0000-0002-2749-857X, Kastrup, Andreas, Zedde, Marialuisa; https://orcid.org/0000-0001-7530-818X, Kägi, Georg; https://orcid.org/0000-0001-7749-8060, Kellert, Lars, Henon, Hilde; https://orcid.org/0000-0001-6274-7562, Curtze, Sami; https://orcid.org/0000-0003-1545-8500, Pezzini, Alessandro; https://orcid.org/0000-0001-8629-3315, Arnold, Marcel; https://orcid.org/0000-0002-4274-4644, Wegener, Susanne; https://orcid.org/0000-0003-4369-7023, Ringleb, Peter, Tatlisumak, Turgut, et al, Traenka, Christopher; https://orcid.org/0000-0002-7600-1005, Lorscheider, Johannes; https://orcid.org/0000-0003-1100-2506, Hametner, Christian; https://orcid.org/0000-0002-9955-5430, Baumgartner, Philipp; https://orcid.org/0000-0003-1525-2019, Gralla, Jan; https://orcid.org/0000-0003-1953-9033, Magoni, Mauro, Martinez-Majander, Nicolas; https://orcid.org/0000-0001-8489-7051, Casolla, Barbara, Feil, Katharina, Pascarella, Rosario; https://orcid.org/0000-0002-0512-9298, Papanagiotou, Panagiotis, Nordanstig, Annika; https://orcid.org/0000-0002-3625-2168, Padjen, Visnja, Cereda, Carlo W; https://orcid.org/0000-0002-6479-1476, Psychogios, Marios; https://orcid.org/0000-0002-0016-414X, Nolte, Christian H; https://orcid.org/0000-0001-5577-1775, Zini, Andrea; https://orcid.org/0000-0003-1486-4507, Michel, Patrik; https://orcid.org/0000-0003-4954-7579, Béjot, Yannick; https://orcid.org/0000-0002-2749-857X, Kastrup, Andreas, Zedde, Marialuisa; https://orcid.org/0000-0001-7530-818X, Kägi, Georg; https://orcid.org/0000-0001-7749-8060, Kellert, Lars, Henon, Hilde; https://orcid.org/0000-0001-6274-7562, Curtze, Sami; https://orcid.org/0000-0003-1545-8500, Pezzini, Alessandro; https://orcid.org/0000-0001-8629-3315, Arnold, Marcel; https://orcid.org/0000-0002-4274-4644, Wegener, Susanne; https://orcid.org/0000-0003-4369-7023, Ringleb, Peter, Tatlisumak, Turgut, and et al

Abstract

Background and Purpose: This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD). Methods: This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015–2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0–2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching. Results: Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10–19] vs. 4 [2–7], P<0.001). The frequency of favorable 3-month outcome did not differ significantly between both groups (EVT: 64.0% vs. IVT: 86.8%; ORadjusted 0.56 [0.24–1.32]). EVT was associated with higher rates of recanalization (80.5% vs. 40.7%; ORadjusted 8.85 [4.28–18.29]) compared to IVT. All secondary analyses showed higher recanalization rates in the EVT-group, which however never translated into better functional outcome rates compared to the IVT-group. Conclusion: We observed no signal of superiority of EVT over IVT regarding functional outcome in CeAD-patients with AIS and LVO despite higher rates of complete recanalization with EVT. Whether pathophysiological CeAD-cha

Published
2023

21. Recanalization Therapies for Large Vessel Occlusion Due to Cervical Artery Dissection: A Cohort Study of the EVA-TRISP Collaboration

Author

Traenka, Christopher, Lorscheider, Johannes, Hametner, Christian, Baumgartner, Philipp, Gralla, Jan, Magoni, Mauro, Martinez-Majander, Nicolas, Casolla, Barbara, Feil, Katharina, Pascarella, Rosario, Papanagiotou, Panagiotis, Nordanstig, Annika, Padjen, Visnja, Cereda, Carlo W, Psychogios, Marios, Nolte, Christian H, Zini, Andrea, Michel, Patrik, Béjot, Yannick, Kastrup, Andreas, Zedde, Marialuisa, Kägi, Georg, Kellert, Lars, Henon, Hilde, Curtze, Sami, Pezzini, Alessandro, Arnold, Marcel, Wegener, Susanne, Ringleb, Peter, Tatlisumak, Turgut, Nederkoorn, Paul J, Engelter, Stefan T, and Gensicke, Henrik

Subjects
610 Medicine & health
Abstract

BACKGROUND AND PURPOSE This study aimed to investigate the effect of endovascular treatment (EVT, with or without intravenous thrombolysis [IVT]) versus IVT alone on outcomes in patients with acute ischemic stroke (AIS) and intracranial large vessel occlusion (LVO) attributable to cervical artery dissection (CeAD). METHODS This multinational cohort study was conducted based on prospectively collected data from the EVA-TRISP (EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients) collaboration. Consecutive patients (2015-2019) with AIS-LVO attributable to CeAD treated with EVT and/or IVT were included. Primary outcome measures were (1) favorable 3-month outcome (modified Rankin Scale score 0-2) and (2) complete recanalization (thrombolysis in cerebral infarction scale 2b/3). Odds ratios with 95% confidence intervals (OR [95% CI]) from logistic regression models were calculated (unadjusted, adjusted). Secondary analyses were performed in the patients with LVO in the anterior circulation (LVOant) including propensity score matching. RESULTS Among 290 patients, 222 (76.6%) had EVT and 68 (23.4%) IVT alone. EVT-treated patients had more severe strokes (National Institutes of Health Stroke Scale score, median [interquartile range]: 14 [10-19] vs. 4 [2-7], P

Published
2023
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22. Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events

Author

Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Vanguru, Husitha Reddy, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Lesaine, Emilie, Nolte, Christian H., Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, Jose Dominguo, Tsivgoulis, Georgios, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P.N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Loochtan, Aaron I., Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Demeestere, Jelle, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Uchino, Ken, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Inoa, Violiza, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Goyal, Nitin, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Charidimou, Andreas, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Siegler, James E., Coutinho, Jonathan M., Rinkel, Leon A., Dippel, Diederik W.J., van Dam-Nolen, Dianne H.K., Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Yaghi, Shadi, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, de Sousa, Diana Aguiar, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Mohammaden, Mahmoud H., Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Haussen, Diogo C., Fonseca, Luisa, Marto, João Pedro, Melo, Teresa Pinho e, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Kristoffersen, Espen Saxhaug, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, García Sánchez, María Jesús, Lereis, Virginia Pujol, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T.P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Scollo, Sergio Daniel, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Özcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, Campbell, Bruce C. V., John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Ma, Alice, Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Thomas, James Orton, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Parsons, Mark W., Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Singhal, Shaloo, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Slater, Lee-Anne, Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutierrez, Santiago, Tomazini Martins, Rodrigo, Puri, Ajit S., Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, Jose Rafael, Rost, Natalia S., Rothstein, Aaron, Enzinger, Chris, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Gattringer, Thomas, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Rahman, Aminur, Nogueira, Raul G., Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C.T., de Oliveira Neves, Luciana, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Lameirinhas da Silva, Isabelle, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Angel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, and Repositório da Universidade de Lisboa

Abstract

© 2022 American Academy of Neurology, Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020). Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations. Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.

Published
2023

24. S100b in acute ischemic stroke clots is a biomarker for post-thrombectomy intracranial hemorrhages

Author

Rossi, Rosanna, primary, Douglas, Andrew, additional, Gil, Sara Molina, additional, Jabrah, Duaa, additional, Pandit, Abhay, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Prendergast, James, additional, Jood, Katarina, additional, Redfors, Petra, additional, Nordanstig, Annika, additional, Ceder, Erik, additional, Dunker, Dennis, additional, Carlqvist, Jeanette, additional, Szikora, István, additional, Thornton, John, additional, Tsivgoulis, Georgios, additional, Psychogios, Klearchos, additional, Tatlisumak, Turgut, additional, Rentzos, Alexandros, additional, and Doyle, Karen M., additional

Published
2023
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25. Tandem occlusions involving the internal carotid and anterior cerebral arteries—A rare form of stroke: Results from the multicenter EVATRISP collaboration study

Author

Filioglo, Andrei, primary, Simaan, Naaem, additional, Honig, Asaf, additional, Heldner, Mirjam, additional, Pezzini, Alessandro, additional, Martinez-Majander, Nicolas, additional, Padjen, Visnja, additional, Baumgartner, Philipp, additional, Papanagiotou, Panagiotis, additional, Salerno, Alexander, additional, Nolte, Christian, additional, Nordanstig, Annika, additional, Engelter, Stefan, additional, Zini, Andrea, additional, Zedde, Marialuisa, additional, Marto, João Pedro, additional, Arnold, Marcel, additional, Magoni, Mauro, additional, Gensicke, Henrik, additional, Cohen, Jose, additional, and Leker, Ronen, additional

Published
2022
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27. Cancer and stroke : commonly encountered by clinicians, but little evidence to guide clinical approach

Author

Woock, Malin, Martinez-Majander, Nicolas, Seiffge, David J., Selvik, Henriette Aurora, Nordanstig, Annika, Redfors, Petra, Lindgren, Erik, Sanchez van Kammen, Mayte, Rentzos, Alexandros, Coutinho, Jonathan M., Doyle, Karen, Naess, Halvor, Putaala, Jukka, Jood, Katarina, Tatlisumak, Turgut, HUS Neurocenter, Neurologian yksikkö, Clinicum, Department of Neurosciences, and University of Helsinki

Subjects
SINUS THROMBOSIS, therapy, EUROPEAN ACADEMY, CRYPTOGENIC STROKE, INTRACRANIAL HEMORRHAGE, RECURRENT STROKE, D-DIMER, 3112 Neurosciences, CEREBRAL VENOUS THROMBOSIS, intracerebral hemorrhage, stroke, 3124 Neurology and psychiatry, clot, diagnostics, ischemic stroke, THROMBOEMBOLIC DISEASE, cancer, hemorrhagic stroke, ACUTE ISCHEMIC-STROKE, ORGANIZATION GUIDELINE, risk
Abstract

The association between stroke and cancer is well-established. Because of an aging population and longer survival rates, the frequency of synchronous stroke and cancer will become even more common. Different pathophysiologic mechanisms have been proposed how cancer or cancer treatment directly or via coagulation disturbances can mediate stroke. Increased serum levels of D-dimer, fibrin degradation products, and CRP are more often seen in stroke with concomitant cancer, and the clot retrieved during thrombectomy has a more fibrin- and platelet-rich constitution compared with that of atherosclerotic etiology. Multiple infarctions are more common in patients with active cancer compared with those without a cancer diagnosis. New MRI techniques may help in detecting typical patterns seen in the presence of a concomitant cancer. In ischemic stroke patients, a newly published cancer probability score can help clinicians in their decision-making when to suspect an underlying malignancy in a stroke patient and to start cancer-screening studies. Treating stroke patients with synchronous cancer can be a delicate matter. Limited evidence suggests that administration of intravenous thrombolysis appears safe in non-axial intracranial and non-metastatic cancer patients. Endovascular thrombectomy is probably rather safe in these patients, but probably futile in most patients placed on palliative care due to their advanced disease. In this topical review, we discuss the epidemiology, pathophysiology, and prognosis of ischemic and hemorrhagic strokes as well as cerebral venous thrombosis and concomitant cancer. We further summarize the current evidence on acute management and secondary preventive therapy.

Published
2022

28. Obesity and the Risk of Cryptogenic Ischemic Stroke in Young Adults

Author

the SECRETO Study Group, Jaakonmäki, Nina, Zedde, Marialuisa, Sarkanen, Tomi, Martinez-Majander, Nicolas, Tuohinen, Suvi, Sinisalo, Juha, Ryödi, Essi, Autere, Jaana, Hedman, Marja, Junttola, Ulla, Huhtakangas, Jaana K., Grimaldi, Teresa, Pascarella, Rosario, Nordanstig, Annika, Bech-Hanssen, Odd, Holbe, Christine, Busch, Raila, Fromm, Annette, Ylikotila, Pauli, Turgut, Esme Ekizoglu, Amorim, Isabel, Ryliskiene, Kristina, Tulkki, Lauri, Pascasio, Laura Amaya, Licenik, Radim, Ferdinand, Phillip, Tsivgoulis, Georgios, Jatužis, Dalius, Kõrv, Liisa, Kõrv, Janika, Pezzini, Alessandro, Fonseca, Ana Catarina, Yesilot, Nilufer, Roine, Risto O., Waje-Andreassen, Ulrike, von Sarnowski, Bettina, Redfors, Petra, Huhtakangas, Juha, Numminen, Heikki, Jäkälä, Pekka, Putaala, Jukka, Tampere University, Department of Neurosciences and Rehabilitation, Clinical Medicine, TAYS Heart Centre, HUS Neurocenter, Neurologian yksikkö, HUS Heart and Lung Center, Department of Medicine, Clinicum, University of Helsinki, Kardiologian yksikkö, Department of Neurosciences, and Repositório da Universidade de Lisboa

Subjects
Male, COUNTRIES, Migraine with Aura, SCREENING TOOL, Cryptogenic stroke, DISEASE, 3124 Neurology and psychiatry, Body Mass Index, Young Adult, Risk Factors, TO-HEIGHT RATIO, Humans, Prospective Studies, Obesity, cryptogenic stroke, ischemic stroke, obesity, waist-to-hip ratio, young adults, Ischemic stroke, Waist-Hip Ratio, Waist-to-hip ratio, Rehabilitation, 3112 Neurosciences, nutritional and metabolic diseases, PREVALENCE, ADIPOSE-TISSUE, Case-Control Studies, 3121 General medicine, internal medicine and other clinical medicine, &nbsp, Surgery, Female, Neurology (clinical), Waist Circumference, Cardiology and Cardiovascular Medicine, BURDEN, Young adults
Abstract

© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), Objectives: We examined the association between obesity and early-onset cryptogenic ischemic stroke (CIS) and whether fat distribution or sex altered this association. Materials and methods: This prospective, multi-center, case-control study included 345 patients, aged 18-49 years, with first-ever, acute CIS. The control group included 345 age- and sex-matched stroke-free individuals. We measured height, weight, waist circumference, and hip circumference. Obesity metrics analyzed included body mass index (BMI), waist-to-hip ratio (WHR), waist-to-stature ratio (WSR), and a body shape index (ABSI). Models were adjusted for age, level of education, vascular risk factors, and migraine with aura. Results: After adjusting for demographics, vascular risk factors, and migraine with aura, the highest tertile of WHR was associated with CIS (OR for highest versus lowest WHR tertile 2.81, 95%CI 1.43-5.51; P=0.003). In sex-specific analyses, WHR tertiles were not associated with CIS. However, using WHO WHR cutoff values (>0.85 for women, >0.90 for men), abdominally obese women were at increased risk of CIS (OR 2.09, 95%CI 1.02-4.27; P=0.045). After adjusting for confounders, WC, BMI, WSR, or ABSI were not associated with CIS. Conclusions: Abdominal obesity measured with WHR was an independent risk factor for CIS in young adults after rigorous adjustment for concomitant risk factors., The study was funded by the Helsinki and Uusimaa Hospital District, Academy of Finland, University of Helsinki, and Sahlgrenska University Hospital.

Published
2022

29. EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Author

Nordanstig, Annika, Curtze, Sami, Gensicke, Henrik, Zinkstok, Sanne M, et al, Luft, Andreas, Wegener, Susanne, Kulcsar, Zsolt, University of Zurich, and Nordanstig, Annika

Subjects
10043 Clinic for Neuroradiology, 610 Medicine & health, 2700 General Medicine, 10040 Clinic for Neurology
Published
2021
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31. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke Registry

Author

Marto, João Pedro, Strambo, Davide, Ntaios, George, Nguyen, Thanh N, Herzig, Roman, Czlonkowska, Anna, Demeestere, Jelle, Mansour, Ossama Yassin, Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W, Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Ramos, João Nuno, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Nunes, Ana Paiva, Ferreira, Patricia, Pinho E Melo, Teresa, Dias, Mariana Carvalho, Paula, André, Correia, Manuel Alberto, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Alves, José Nuno, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araujo, Andre Pinho, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Malheiro, Sofia, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, La Gioia, Sara, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Ferrarese, Carlo, Beretta, Simone, Diamanti, Susanna, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maïer, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loïc, Cuisenier, Pauline, Vodret, Francesca R, Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O, Schaefer, Jan Hendrik, Nolte, Christian, Audebert, Heinrich J, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke Ruth, Stolp, Jeffrey, Stolze, Lotte J, Coutinho, Jonathan M, Nederkoorn, Paul, van den Wijngaard, Ido, De Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Rutgers, Matthieu Pierre, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Perez-Sanchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Pérez-de-la-Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Sagarra-Mur, Daniel, Serrano-Ponz, Marta, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David, Kristoffersen, Espen Saxhaug, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulik, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Jurak, Lubomir, Eichlová, Zuzana, Jíra, Martin, Kovar, Martin, Panský, Michal, Mencl, Pavel, Palouskova, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Sramek, Martin, Havlicek, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karlinski, Michal Adam, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiacek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielinska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Slawomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Labuz-Roszak, Beata M, Debiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena Oana, Radu, Razvan Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Ozdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ismail, Ismail Ibrahim, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu Ionut, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada A, Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenney P, Khan, Muhib, Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham, Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael G, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz M, Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel Ángel, Barrientos Guerra, Jose Dominguo, Caetano, Rayllene, Martins, Rodrigo Targa, Scollo, Sergio Daniel, Yalung, Patrick Matic, Nagendra, Shashank, Gaikwad, Abhijit, Seo, Kwon-Duk, Georgiopoulos, Georgios, Nogueira, Raul G, Michel, Patrik, Neurology, Clinical sciences, Neuroprotection & Neuromodulation, Faculty of Medicine and Pharmacy, Biology, and Brussels Heritage Lab

Subjects
Fibrinolytic Agents/therapeutic use, Cerebral Hemorrhage/complications, Stroke/epidemiology, Brain Ischemia/complications, Treatment Outcome, Ischemic Stroke/epidemiology, COVID-19/complications, Humans, Cohort studies, Endovascular Procedures/adverse effects, Registries, Neurology (clinical), 610 Medicine & health, Intracranial Hemorrhages/etiology, Thrombolytic Therapy/adverse effects, Research Article
Abstract

Background and ObjectivesCOVID-19–related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the safety and outcomes of revascularization treatments in patients with AIS and COVID-19.MethodsThis was a retrospective multicenter cohort study of consecutive patients with AIS receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021 tested for severe acute respiratory syndrome coronavirus 2 infection. With a doubly robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT).ResultsOf a total of 15,128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19; of those, 5,848 (38.7%) patients received IVT-only and 9,280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted OR 1.53; 95% CI 1.16–2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20–2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23–1.99), 24-hour mortality (OR 2.47; 95% CI 1.58–3.86), and 3-month mortality (OR 1.88; 95% CI 1.52–2.33). Patients with COVID-19 also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26–1.60).DiscussionPatients with AIS and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non–COVID-19 patients receiving treatment. Current available data do not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in patients with COVID-19 or to establish different treatment recommendations in this subgroup of patients with ischemic stroke. Our findings can be taken into consideration for treatment decisions, patient monitoring, and establishing prognosis.Trial Registration InformationThe study was registered under ClinicalTrials.gov identifierNCT04895462.

Published
2022
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33. Cancer and stroke: commonly encountered by clinicians, but little evidence to guide clinical approach

Author

Woock, Malin, primary, Martinez-Majander, Nicolas, additional, Seiffge, David J., additional, Selvik, Henriette Aurora, additional, Nordanstig, Annika, additional, Redfors, Petra, additional, Lindgren, Erik, additional, Sanchez van Kammen, Mayte, additional, Rentzos, Alexandros, additional, Coutinho, Jonathan M., additional, Doyle, Karen, additional, Naess, Halvor, additional, Putaala, Jukka, additional, Jood, Katarina, additional, and Tatlisumak, Turgut, additional

Published
2022
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34. Corrigendum: Tandem occlusions involving the internal carotid and anterior cerebral arteries—A rare form of stroke: results from the multicenter EVATRISP collaboration study.

Author

Filioglo, Andrei, Simaan, Naaem, Honig, Asaf, Heldner, Mirjam, Pezzini, Alessandro, Martinez-Majander, Nicolas, Padjen, Visnja, Baumgartner, Philipp, Papanagiotou, Panagiotis, Salerno, Alexander, Nolte, Christian, Nordanstig, Annika, Engelter, Stefan, Zini, Andrea, Zedde, Marialuisa, Marto, João Pedro, Arnold, Marcel, Magoni, Mauro, Gensicke, Henrik, and Cohen, Jose

Published
2024
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35. Characterization of the 'White' Appearing Clots that Cause

Author

Mereuta, Oana Madalina Rossi, Rosanna Douglas, Andrew Gil, Sara Molina Fitzgerald, Sean Pandit, Abhay McCarthy, Ray and Gilvarry, Michael Ceder, Eric Dunker, Dennis Nordanstig, Annika Redfors, Petra Jood, Katarina Magou, Georgios and Psychogios, Klearchos Tsivgoulis, Georgios O'Hare, Alan and Power, Sarah Brennan, Paul Nagy, Andras Vadasz, Agnes and Brinjikji, Waleed Kallmes, David F. Szikora, Istvan Rentzos, Alexandros Tatlisumak, Turgut Thornton, John Doyle, Karen M.

Subjects
circulatory and respiratory physiology
Abstract

Objectives: Most clots retrieved from patients with acute ischemic stroke are ‘red’ in color. ‘White’ clots represent a less common entity and their histological composition is less known. Our aim was to investigate the composition, imaging and procedural characteristics of ‘white’ clots retrieved by mechanical thrombectomy. Materials and methods: Seventy five ‘white’ thrombi were selected by visual inspection from a cohort of 760 clots collected as part of the RESTORE registry. Clots were evaluated histopathologically. Results: Quantification of Martius Scarlett Blue stain identified platelets/other as the major component in ‘white’ clots’ (mean of 55% of clot overall composition) followed by fibrin (31%), red blood cells (6%) and white blood cells (3%). ‘White’ clots contained significantly more platelets/other (p

Published
2021

36. sj-pdf-1-eso-10.1177_23969873211024777 - Supplemental material for Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization

Author

Rossi, Rosanna, Fitzgerald, Seán, Gil, Sara M, Mereuta, Oana M, Douglas, Andrew, Pandit, Abhay, Brennan, Paul, Power, Sarah, Alderson, Jack, O’Hare, Alan, Gilvarry, Michael, McCarthy, Ray, Psychogios, Klearchos, Magoufis, Georgios, Tsivgoulis, Georgios, Szikora, István, Jood, Katarina, Redfors, Petra, Nordanstig, Annika, Ceder, Erik, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, and Doyle, Karen M

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-eso-10.1177_23969873211024777 for Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization by Rosanna Rossi, Seán Fitzgerald, Sara M Gil, Oana M Mereuta, Andrew Douglas, Abhay Pandit, Paul Brennan, Sarah Power, Jack Alderson, Alan O’Hare, Michael Gilvarry, Ray McCarthy, Klearchos Psychogios, Georgios Magoufis, Georgios Tsivgoulis, István Szikora, Katarina Jood, Petra Redfors, Annika Nordanstig, Erik Ceder, Turgut Tatlisumak, Alexandros Rentzos, John Thornton and Karen M Doyle in European Stroke Journal

Published
2021
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37. sj-pdf-2-eso-10.1177_23969873211024777 - Supplemental material for Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization

Author

Rossi, Rosanna, Fitzgerald, Seán, Gil, Sara M, Mereuta, Oana M, Douglas, Andrew, Pandit, Abhay, Brennan, Paul, Power, Sarah, Alderson, Jack, O’Hare, Alan, Gilvarry, Michael, McCarthy, Ray, Psychogios, Klearchos, Magoufis, Georgios, Tsivgoulis, Georgios, Szikora, István, Jood, Katarina, Redfors, Petra, Nordanstig, Annika, Ceder, Erik, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, and Doyle, Karen M

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-2-eso-10.1177_23969873211024777 for Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization by Rosanna Rossi, Seán Fitzgerald, Sara M Gil, Oana M Mereuta, Andrew Douglas, Abhay Pandit, Paul Brennan, Sarah Power, Jack Alderson, Alan O’Hare, Michael Gilvarry, Ray McCarthy, Klearchos Psychogios, Georgios Magoufis, Georgios Tsivgoulis, István Szikora, Katarina Jood, Petra Redfors, Annika Nordanstig, Erik Ceder, Turgut Tatlisumak, Alexandros Rentzos, John Thornton and Karen M Doyle in European Stroke Journal

Published
2021
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38. Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization

Author

Rossi, Rosanna Fitzgerald, Sean Gil, Sara M. Mereuta, Oana M. Douglas, Andrew Pandit, Abhay Brennan, Paul Power, Sarah Alderson, Jack O'Hare, Alan Gilvarry, Michael and McCarthy, Ray Psychogios, Klearchos Magoufis, Georgios and Tsivgoulis, Georgios Szikora, Istvan Jood, Katarina Redfors, Petra Nordanstig, Annika Ceder, Erik Tatlisumak, Turgut and Rentzos, Alexandros Thornton, John Doyle, Karen M.

Subjects
cardiovascular diseases, circulatory and respiratory physiology
Abstract

Introduction: We assessed the correlation between thrombus size before and after mechanical thrombectomy, measured as length by Computed Tomography Angiography/Non-Contrast Computed Tomography (CTA/NCCT) and Extracted Clot Area, ECA, respectively. We also assessed the influence of thrombus size on the number of passes required for clot removal and final recanalization outcome. Materials and methods: Acute ischaemic stroke (AIS) thrombi retrieved by mechanical thrombectomy from 500 patients and data of clot length by CTA/NCCT were collected from three hospitals in Europe. ECA was obtained by measuring the area of the extracted clot. Non-parametric tests were used for data analysis. Results: A strong positive correlation was found between clot length on CTA/NCCT and ECA (rho = 0.619,N = 500, P < 0.0001*). Vessel size influences clot length on CTA/NCCT (H2 = 98.6, P < 0.0001*) and ECA (H2 = 105.6,P < 0.0001*), but the significant correlation between CTA/NCCT length and ECA was evident in all vessels. Poorer revascularisation outcome was associated with more passes (H5 = 73.1, P < 0.0001*). More passes were required to remove longer clots (CTA/NCCT; H4 = 31.4, P < 0.0001*; ECA; H4 = 50.2, P < 0.0001*). There was no significant main association between recanalization outcome and length on CTA/NCCT or ECA, but medium sized clots (ECA 20-40 mm(2)) were associated with least passes and highest revascularisation outcome (N = 500, X-2 = 16.2, P < 0.0001*). Conclusion: Clot length on CTA/NCCT strongly correlates with ECA. Occlusion location influences clot size. More passes are associated with poorer revascularisation outcome and bigger clots. The relationship between size and revascularisation outcome is more complex. Clots of medium ECA take less passes to remove and are associated with better recanalization outcome than both smaller and larger clots.

Published
2021

39. Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition

Author

Fitzgerald, Sean Rossi, Rosanna Mereuta, Oana Madalina and Jabrah, Duaa Okolo, Adaobi Douglas, Andrew Molina Gil, Sara and Pandit, Abhay McCarthy, Ray Gilvarry, Michael Dunker, Dennis Nordanstig, Annika Ceder, Erik Redfors, Petra and Jood, Katarina Dehlfors, Niclas Magoufis, Georgios and Tsivgoulis, Georgios Brinjikji, Waleed Kallmes, David F. and O'Hare, Alan Power, Sarah Brennan, Paul Alderson, Jack and Nagy, Andras Vadasz, Agnes Psychogios, Klearchos Szikora, Istvan Tatlisumak, Turgut Rentzos, Alexandros Thornton, John and Doyle, Karen M.

Subjects
circulatory and respiratory physiology
Abstract

Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots. Objective To report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass. Methods As part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated. Results Clot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1-3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes. Conclusion LAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms.

Published
2021

40. Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry

Author

Rossi, Rosanna, primary, Molina, Sara, additional, Mereuta, Oana Madalina, additional, Douglas, Andrew, additional, Fitzgerald, Seán, additional, Tierney, Ciara, additional, Pandit, Abhay, additional, Brennan, Paul, additional, Power, Sarah, additional, O’Hare, Alan, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Magoufis, Georgios, additional, Tsivgoulis, Georgios, additional, Nagy, András, additional, Vadász, Ágnes, additional, Jood, Katarina, additional, Redfors, Petra, additional, Nordanstig, Annika, additional, Ceder, Erik, additional, Dunker, Dennis, additional, Carlqvist, Jeanette, additional, Psychogios, Klearchos, additional, Szikora, István, additional, Tatlisumak, Turgut, additional, Rentzos, Alexandros, additional, Thornton, John, additional, and Doyle, Karen M., additional

Published
2021
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41. EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Author

Nordanstig, Annika, primary, Curtze, Sami, additional, Gensicke, Henrik, additional, Zinkstok, Sanne M, additional, Erdur, Hebun, additional, Karlsson, Camilla, additional, Karlsson, Jan-Erik, additional, Martinez-Majander, Nicolas, additional, Sibolt, Gerli, additional, Lyrer, Philippe, additional, Traenka, Christopher, additional, Baharoglu, Merih I, additional, Scheitz, Jan F, additional, Bricout, Nicolas, additional, Hénon, Hilde, additional, Leys, Didier, additional, Eskandari, Ashraf, additional, Michel, Patrik, additional, Hametner, Christian, additional, Ringleb, Peter Arthur, additional, Arnold, Marcel, additional, Fischer, Urs, additional, Sarikaya, Hakan, additional, Seiffge, David J, additional, Pezzini, Alessandro, additional, Zini, Andrea, additional, Padjen, Visnja, additional, Jovanovic, Dejana R, additional, Luft, Andreas, additional, Wegener, Susanne, additional, Kellert, Lars, additional, Feil, Katharina, additional, Kägi, Georg, additional, Rentzos, Alexandros, additional, Lappalainen, Kimmo, additional, Leker, Ronen R, additional, Cohen, Jose E, additional, Gomori, John, additional, Brehm, Alex, additional, Liman, Jan, additional, Psychogios, Marios, additional, Kastrup, Andreas, additional, Papanagiotou, Panagiotis, additional, Gralla, Jan, additional, Magoni, Mauro, additional, Majoie, Charles B L M, additional, Bohner, Georg, additional, Vukasinovic, Ivan, additional, Cvetic, Vladimir, additional, Weber, Johannes, additional, Kulcsar, Zsolt, additional, Bendszus, Martin, additional, Möhlenbruch, Markus, additional, Ntaios, George, additional, Kapsalaki, Eftychia, additional, Jood, Katarina, additional, Nolte, Christian H, additional, Nederkoorn, Paul J J, additional, Engelter, Stefan, additional, Strbian, Daniel, additional, and Tatlisumak, Turgut, additional

Published
2021
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42. Correlation between acute ischaemic stroke clot length before mechanical thrombectomy and extracted clot area: Impact of thrombus size on number of passes for clot removal and final recanalization

Author

Rossi, Rosanna, primary, Fitzgerald, Seán, additional, Gil, Sara M, additional, Mereuta, Oana M, additional, Douglas, Andrew, additional, Pandit, Abhay, additional, Brennan, Paul, additional, Power, Sarah, additional, Alderson, Jack, additional, O’Hare, Alan, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Psychogios, Klearchos, additional, Magoufis, Georgios, additional, Tsivgoulis, Georgios, additional, Szikora, István, additional, Jood, Katarina, additional, Redfors, Petra, additional, Nordanstig, Annika, additional, Ceder, Erik, additional, Tatlisumak, Turgut, additional, Rentzos, Alexandros, additional, Thornton, John, additional, and Doyle, Karen M, additional

Published
2021
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43. EndoVAscular treatment and ThRombolysis for Ischemic Stroke Patients (EVA-TRISP) registry: basis and methodology of a pan-European prospective ischaemic stroke revascularisation treatment registry

Author

Nordanstig, Annika; https://orcid.org/0000-0002-3625-2168, Curtze, Sami, Gensicke, Henrik, Zinkstok, Sanne M, et al, Luft, Andreas, Wegener, Susanne, Kulcsar, Zsolt, Nordanstig, Annika; https://orcid.org/0000-0002-3625-2168, Curtze, Sami, Gensicke, Henrik, Zinkstok, Sanne M, et al, Luft, Andreas, Wegener, Susanne, and Kulcsar, Zsolt

Abstract

PURPOSE The Thrombolysis in Ischemic Stroke Patients (TRISP) collaboration was a concerted effort initiated in 2010 with the purpose to address relevant research questions about the effectiveness and safety of intravenous thrombolysis (IVT). The collaboration also aims to prospectively collect data on patients undergoing endovascular treatment (EVT) and hence the name of the collaboration was changed from TRISP to EVA-TRISP. The methodology of the former TRISP registry for patients treated with IVT has already been published. This paper focuses on describing the EVT part of the registry. PARTICIPANTS All centres committed to collecting predefined variables on consecutive patients prospectively. We aim for accuracy and completeness of the data and to adapt local databases to investigate novel research questions. Herein, we introduce the methodology of a recently constructed academic investigator-initiated open collaboration EVT registry built as an extension of an existing IVT registry in patients with acute ischaemic stroke (AIS). FINDINGS TO DATE Currently, the EVA-TRISP network includes 20 stroke centres with considerable expertise in EVT and maintenance of high-quality hospital-based registries. Following several successful randomised controlled trials (RCTs), many important clinical questions remain unanswered in the (EVT) field and some of them will unlikely be investigated in future RCTs. Prospective registries with high-quality data on EVT-treated patients may help answering some of these unanswered issues, especially on safety and efficacy of EVT in specific patient subgroups. FUTURE PLANS This collaborative effort aims at addressing clinically important questions on safety and efficacy of EVT in conditions not covered by RCTs. The TRISP registry generated substantial novel data supporting stroke physicians in their daily decision making considering IVT candidate patients. While providing observational data on EVT in daily clinical practice, our future findi

Published
2021

44. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19

Author

Marto, João Pedro, Strambo, Davide, Ntaios, George, Nguyen, Thanh N., Herzig, Roman, Czlonkowska, Anna, Demeestere, Jelle, Mansour, Ossama Yassin, Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Ramos, João Nuno, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Nunes, Ana Paiva, Ferreira, Patricia, Pinho e Melo, Teresa, Dias, Mariana Carvalho, Paula, André, Correia, Manuel Alberto, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Alves, José Nuno, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araujo, Andre Pinho, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Malheiro, Sofia, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, La Gioia, Sara, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Ferrarese, Carlo, Beretta, Simone, Diamanti, Susanna, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maïer, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loïc, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Schaefer, Jan Hendrik, Nolte, Christian, Audebert, Heinrich J., Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul, van den Wijngaard, Ido, De Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Rutgers, Matthieu Pierre, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Perez-Sanchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Pérez-de-la-Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Sagarra-Mur, Daniel, Serrano-Ponz, Marta, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David, Kristoffersen, Espen Saxhaug, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulik, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Jurak, Lubomir, Eichlová, Zuzana, Jíra, Martin, Kovar, Martin, Panský, Michal, Mencl, Pavel, Palouskova, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Sramek, Martin, Havlicek, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karlinski, Michal Adam, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiacek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielinska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Slawomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Labuz-Roszak, Beata M., Debiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena Oana, Radu, Razvan Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Ozdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ismail, Ismail Ibrahim, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu Ionut, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenney P., Khan, Muhib, Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham, Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael G., Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel Ángel, Barrientos Guerra, Jose Dominguo, Caetano, Rayllene, Martins, Rodrigo Targa, Scollo, Sergio Daniel, Yalung, Patrick Matic, Nagendra, Shashank, Gaikwad, Abhijit, Seo, Kwon-Duk, Georgiopoulos, Georgios, Nogueira, Raul G., and Michel, Patrik

Published
2023
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45. Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition

Author

Fitzgerald, Seán, primary, Rossi, Rosanna, additional, Mereuta, Oana Madalina, additional, Jabrah, Duaa, additional, Okolo, Adaobi, additional, Douglas, Andrew, additional, Molina Gil, Sara, additional, Pandit, Abhay, additional, McCarthy, Ray, additional, Gilvarry, Michael, additional, Dunker, Dennis, additional, Nordanstig, Annika, additional, Ceder, Erik, additional, Redfors, Petra, additional, Jood, Katarina, additional, Dehlfors, Niclas, additional, Magoufis, Georgios, additional, Tsivgoulis, Georgios, additional, Brinjikji, Waleed, additional, Kallmes, David F, additional, O'Hare, Alan, additional, Power, Sarah, additional, Brennan, Paul, additional, Alderson, Jack, additional, Nagy, András, additional, Vadász, Ágnes, additional, Psychogios, Klearchos, additional, Szikora, Istvan, additional, Tatlisumak, Turgut, additional, Rentzos, Alexandros, additional, Thornton, John, additional, and Doyle, Karen M, additional

Published
2020
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46. The administration of rtPA before mechanical thrombectomy in acute ischemic stroke patients is associated with a significant reduction of the retrieved clot area but it does not influence revascularization outcome

Author

Rossi, Rosanna, primary, Fitzgerald, Seán, additional, Molina, Sara, additional, Mereuta, Oana Madalina, additional, Douglas, Andrew, additional, Pandit, Abhay, additional, Santos, Andreia M. Silva, additional, Murphy, Blathnaid, additional, Alderson, Jack, additional, Brennan, Paul, additional, Power, Sarah, additional, O’Hare, Alan, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Psychogios, Klearchos, additional, Magoufis, Georgios, additional, Tsivgoulis, Georgios, additional, Nagy, András, additional, Vadász, Ágnes, additional, Szikora, István, additional, Jood, Katarina, additional, Redfors, Petra, additional, Nordanstig, Annika, additional, Ceder, Erik, additional, Dehlfors, Niclas, additional, Dunker, Dennis, additional, Tatlisumak, Turgut, additional, Rentzos, Alexandros, additional, Thornton, John, additional, and Doyle, Karen M., additional

Published
2020
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47. Do patients with large vessel occlusion ischemic stroke harboring prestroke disability benefit from thrombectomy?

Author

Larsson, Alice, primary, Karlsson, Camilla, additional, Rentzos, Alexandros, additional, Schumacher, Marcus, additional, Abrahamson, Margareta, additional, Allardt, Arne, additional, Brederlau, Anke, additional, Ceder, Erik, additional, Davidson, Maria, additional, Dunker, Dennis, additional, Gunnarsson, Thorsteinn, additional, Holmegaard, Lukas, additional, Jerndal, Mikael, additional, Karlsson, Jan-Erik, additional, Nordanstig, Annika, additional, Redfors, Petra, additional, Rosengren, Lars, additional, Tatlisumak, Turgut, additional, and Jood, Katarina, additional

Published
2020
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49. Does bridging therapy in mechanical thrombectomy increase recanalization rates in ischemic stroke patients affected by acute large vessel occlusion?

Author

Silva Santos, Andreia M., Rossi, Rosanna, Pandit, Abhay, Fitzgerald, Seán, Mereuta, Oana Madalina, Douglas, Andrew, Thornton, John, Brennan, Paul, Power, Sarah, O’Hare, Alan, Rentzos, Alexandros, Ceder, Erik, Tatlisumak, Turgut, Jood, Katarina, Redfors, Petra, Nordanstig, Annika, Duffy, Sharon, Gilvarry, Michael, McCarthy, Ray, Doyle, Karen M., Science Foundation Ireland, and Cerenovus

Subjects
mechanical thrombectomy, bridging therapy, ischemic stroke patients, recanalization, acute large vessel occlusion
Abstract

Both intravenous thrombolysis with tissue plasminogen activator (IV-rtPA) and mechanical thrombectomy (MT) increase recanalization rates. We assessed if bridging-therapy (the concomitant use of rtPA and MT) could increase the recanalization rates and reduce the number of procedural passes in patients suffering from acute ischemic stroke (AIS) when compared to MT alone. Analysis of type of device used, stentriever or aspiration catheter, is also reported. 334 mechanically extracted thrombi were collected from two partner hospitals: Beaumont (Dublin) and Sahlgrenska (Gothenburg). 158 patients (47.3%) were treated with bridging-therapy, while 176 (52.7%) underwent MT alone. Recanalization rate was defined by using the modified Thrombolysis In Cerebral Infarction (mTICI) score. Non-parametric Kruskal-Wallis test was used for statistical analysis. Bridging-therapy reduced the total number of passes to remove the clot (mean for MT+rtPA=2.27±2.10, MT alone=2.63±1.88, H1=4.376, p=0.036*). Analysing the device, rtPA lowered the overall number of passes using stentriever devices (mean for MT+rtPA=1.57±1.12, MT alone=2.36±1.48, H1=8.303, p=0.004*), but not for aspiration (mean for MT+rt-PA=1.78±1.22, MT alone=2.03±1.47, for H1=0.795, p=0.372). Also, when using both devices no significant reduction of number of passes was observed (mean for MT+rtPA=3.29±2.90, MT alone=3.83±2.20, H1=3.027, p=0.082). There was no significant effect on final mTICI score using bridging-therapy when compared to MT alone (H1=1.163, p=0.281). This small study suggests that bridging-therapy lowers the number of procedural passes in MT procedures, specifically when using stentriever devices. However, this did not have a significant effect on final mTICI score. Funding: Science Foundation Ireland (Grant Number 13/RC/2073) and Cerenovus. Funding: Science Foundation Ireland (Grant Number 13/RC/2073) and Cerenovus. non-peer-reviewed

Published
2019

50. Per- pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition.

Author

Fitzgerald, Seán, Rossi, Rosanna, Mereuta, Oana Madalina, Jabrah, Duaa, Okolo, Adaobi, Douglas, Andrew, Gil, Sara Molina, Pandit, Abhay, McCarthy, Ray, Gilvarry, Michael, Dunker, Dennis, Nordanstig, Annika, Ceder, Erik, Redfors, Petra, Jood, Katarina, Dehlfors, Niclas, Magoufis, Georgios, Tsivgoulis, Georgios, Brinjikji, Waleed, and Kallmes, David F.

Subjects
CEREBRAL embolism & thrombosis, RESEARCH, STAINS & staining (Microscopy), STROKE, ISCHEMIC stroke, BLOOD platelets, MEDICAL cooperation, VEIN surgery, FIBRIN, THROMBECTOMY, STROKE patients, DESCRIPTIVE statistics, ERYTHROCYTES
Abstract

Background Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non- cardioembolic clots. Objective To report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass. Methods As part of the multi- institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per- pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated. Results Clot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell- rich than other etiologies in passes 1--3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes. Conclusion LAA clots are larger and associated with a large red blood cell- rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/ other content than LAA clots, making them stiffer clots. The per- pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms. [ABSTRACT FROM AUTHOR]

Published
2021
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