5 results on '"Norberto Sánchez-Escobar"'
Number of results to display per page
Search Results
2. Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population
- Author
-
Minerva Mata-Rocha, Angelica Rangel-López, Elva Jimenez-Hernandez, Juan Carlos Nuñez-Enríquez, Blanca Angélica Morales-Castillo, Norberto Sánchez-Escobar, Omar Alejandro Sepúlveda-Robles, Juan Carlos Bravata-Alcántara, Alan Steve Nájera-Cortés, María Luisa Pérez-Saldivar, Janet Flores-Lujano, David Aldebarán Duarte-Rodríguez, Norma Angélica Oviedo de Anda, Maria de los Angeles Romero Tlalolini, Carmen Alaez Verson, Jorge Alfonso Martín-Trejo, Jose Esteban Muñoz Medina, Cesar Raul Gonzalez-Bonilla, Maria de los Angeles Hernandez Cueto, VC. Bekker-Méndez, Silvia Jiménez-Morales, Aurora Medina-Sansón, Raquel Amador-Sánchez, José Gabriel Peñaloza-González, José Refugio Torres-Nava, Rosa Martha Espinosa-Elizondo, Beatriz Cortés-Herrera, Luz Victoria Flores-Villegas, Laura Elizabeth Merino-Pasaye, Maria de Lourdes Gutierrez-Rivera, Martha Margarita Velazquez-Aviña, Jessica Denisse Santillan-Juarez, Alma Gurrola-Silva, Gabriela Alicia Hernández Echáurregui, Alfredo Hidalgo-Miranda, José Arellano Galindo, Haydeé Rosas-Vargas, and Juan Manuel Mejía-Aranguré
- Subjects
fusion gene ,acute lymphoblastic leukemia ,prognosis ,RT-qPCR ,molecular biomarkers ,Pediatrics ,RJ1-570 - Abstract
ETV6::RUNX1 is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL). In Mexico, its prevalence is low in comparison with Caucasian populations. We developed a novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a cohort of Hispanic children with ALL from Mexico City. The prevalence of common fusion gene transcripts was as follows: TCF3::PBX1 7.7%; BCR::ABL1p190 3.3%; and KMT2A::AFF1 2.8%, and ETV6::RUNX1was observed with low prevalence (10.5%) in comparison to that reported for developed countries. This is consistent with previous findings on Mexican children with ALL and similar to those reported on children from Hispanic populations. The confirmation of a low prevalence of ETV6::RUNX1 in children of a Hispanic origin represents an advancement in the description of genetic factors of ALL in these populations.
- Published
- 2022
- Full Text
- View/download PDF
3. Analytical study of
- Author
-
Omar, Sepúlveda-Robles, Elva, Jiménez-Hernández, Victoria, Domínguez-Catzín, Eber, Gómez-Flores, Jorge Alfonso, Martín-Trejo, Janet, Flores-Lujano, José Refugio, Torres-Nava, Juan Carlos, Núñez-Enríquez, Marlon, De Ita, Aurora, Medina-Sanson, Minerva, Mata-Rocha, Blanca Angelica, Morales-Castillo, Juan Carlos, Bravata-Alcántara, Alan Steve, Nájera-Cortés, Norberto, Sánchez-Escobar, José Gabriel, Peñaloza-Gonzalez, Rosa Martha, Espinosa-Elizondo, Luz Victoria, Flores-Villegas, Raquel, Amador-Sanchez, Darío, Orozco-Ruiz, Maria Luisa, Pérez-Saldívar, Martha Margarita, Velázquez-Aviña, Laura Elizabeth, Merino-Pasaye, Karina Anastacia, Solís-Labastida, Ana Itamar, González-Ávila, Jessica Denisse, Santillán-Juárez, Vilma Carolina, Bekker-Méndez, Silvia, Jiménez-Morales, Angélica, Rangel-López, Haydeé, Rosas-Vargas, and Juan Manuel, Mejía-Aranguré
- Abstract
The distribution ofWe retrospectively analyzed the presence ofThe overall frequency of the fusion genes was 50.7%;The pediatric population of Mexico City with AML had frequencies of
- Published
- 2022
4. Low Prevalence of
- Author
-
Minerva, Mata-Rocha, Angelica, Rangel-López, Elva, Jimenez-Hernandez, Juan Carlos, Nuñez-Enríquez, Blanca Angélica, Morales-Castillo, Norberto, Sánchez-Escobar, Omar Alejandro, Sepúlveda-Robles, Juan Carlos, Bravata-Alcántara, Alan Steve, Nájera-Cortés, María Luisa, Pérez-Saldivar, Janet, Flores-Lujano, David Aldebarán, Duarte-Rodríguez, Norma Angélica, Oviedo de Anda, Maria de Los Angeles, Romero Tlalolini, Carmen, Alaez Verson, Jorge Alfonso, Martín-Trejo, Jose Esteban, Muñoz Medina, Cesar Raul, Gonzalez-Bonilla, Maria de Los Angeles, Hernandez Cueto, V C, Bekker-Méndez, Silvia, Jiménez-Morales, Aurora, Medina-Sansón, Raquel, Amador-Sánchez, José Gabriel, Peñaloza-González, José Refugio, Torres-Nava, Rosa Martha, Espinosa-Elizondo, Beatriz, Cortés-Herrera, Luz Victoria, Flores-Villegas, Laura Elizabeth, Merino-Pasaye, Maria de Lourdes, Gutierrez-Rivera, Martha Margarita, Velazquez-Aviña, Jessica Denisse, Santillan-Juarez, Alma, Gurrola-Silva, Gabriela Alicia, Hernández Echáurregui, Alfredo, Hidalgo-Miranda, José, Arellano Galindo, Haydeé, Rosas-Vargas, and Juan Manuel, Mejía-Aranguré
- Published
- 2021
5. Development and Validation of a One-Step RT-qPCR Assay for Identifying Common Fusion Gene Transcripts Associated with the Prognosis of Mexican Children with B-Lineage Acute Lymphoblastic Leukemia
- Author
-
Raquel Amador-Sánchez, David Aldebarán Duarte-Rodríguez, Juan Manuel Mejía-Aranguré, Juan Carlos Bravata-Alcántara, Norberto Sánchez-Escobar, Minerva Mata-Rocha, Alma Gurrola-Silva, Karina Anastacia Solís-Labastida, Carmen Alaez Verson, Elva Jiménez-Hernández, Gabriela Alicia Hernández Echáurregui, Luz Victoria Flores-Villegas, Juan Carlos Núñez-Enríquez, Laura Elizabeth Merino-Pasaye, Jessica Denisse Santillán-Juárez, Jorge Alfonso Martín-Trejo, Rosa Martha Espinosa-Elizondo, Angélica Rangel-López, José Refugio Torres-Nava, Alejandra Jimena García-Velázquez, Blanca Angélica Morales-Castillo, Haydeé Rosas-Vargas, Maria de los Angeles Hernandez Cueto, César González-Bonilla, María Luisa Pérez-Saldivar, Maria de los Angeles del Campo-Martinez, José Esteban Muñoz-Medina, José Gabriel Peñaloza-González, Beatriz Cortés-Herrera, Norma Angélica Oviedo de Anda, Alan Steve Nájera-Cortés, Aurora Medina-Sanson, Martha Margarita Velázquez-Aviña, Janet Flores-Lujano, and Omar Alejandro Sepúlveda-Robles
- Subjects
Fusion gene ,Genetics ,Lineage (genetic) ,Lymphoblastic Leukemia ,Biology - Abstract
The aims of the present study were to optimize the detection of common fusion gene transcripts associated with childhood B-ALL prognosis through the development and validation of a one-step RT-qPCR assay and to identify the prevalence of these genes in a cohort of pediatric patients attended in public hospitals in Mexico City. The one-step RT-qPCR assay was sensitive, specific, easy to use, fast and cost efficient. The standard curves were linear, with amplification efficiencies between 97-107%; coefficients of variation were 2.1-3.0% in reproducibility and 2.6-3.8% in repeatability, with agreement between two different laboratories. The prevalence of fusion gene transcripts was ETV6-RUNX1, 10.3%; TCF3-PBX1, 7.5%; BCR-ABL1p190, 3.6%; and KMT2A-AFF1, 2.8%. The prevalence of the ETV6-RUNX1 fusion was low, consistent with the findings in Hispanics. The KMT2A-AFF1 fusion was not exclusively present in infants, as we also found it in patients 4-16 years of age, in whom it was related to a poor prognosis. TCF3-PBX1 patients were associated with an intermediate outcome. The present study highlights the importance of the detection of common genetic fusions in Mexican children with ALL, taking into account that some have molecular subtypes associated with a poor prognosis.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.