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584 results on '"Norberto, Lorenzo"'

3. Gastrointestinal stromal tumors: report of an audit and review of the literature

Author

Biasco, Guido, Velo, Daniela, Angriman, Imerio, Astorino, Maria, Baldan, Anna, Baseggio, Matteo, Basso, Umberto, Battaglia, Giorgio, Bertin, Matteo, Bertorelle, Roberta, Bocus, Paolo, Brosolo, Piero, Bulzacchi, Andrea, Cannizzaro, Renato, Da Dalt, Gian Franco, Di Battista, Monica, Errante, Domenico, Fedrigo, Marny, Frustaci, Sergio, Lionetti, Ivana, Massani, Marco, Mencarelli, Roberto, Montesco, Maria Cristina, Norberto, Lorenzo, Pantaleo, Maria Abbondanza, Pasquali, Claudio, Pastorelli, Davide, Rossi, Carlo Remigio, Ruffolo, Cesare, Salvagno, Luigi, Saponara, Maria Stella, Vittadello, Fabrizio, Zaccaria, Francesco, Zovato, Stefania, and Farinati, Fabio

Published
2009

17. Lessons learned about steered molecular dynamics simulations and free energy calculations

Author

Fernando Martín Boubeta, Mariela Sued, Mehrnoosh Arrar, Ezequiel Norberto Lorenzo, Darío A. Estrin, Rocío María Contestín García, and Leonardo Boechi

Subjects
Pharmacology, Physics, Work (thermodynamics), Likelihood Functions, 010405 organic chemistry, Gaussian, Organic Chemistry, Estimator, Molecular Dynamics Simulation, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, symbols.namesake, Molecular dynamics, Jarzynski equality, Drug Discovery, symbols, Molecular Medicine, Thermodynamics, Statistical physics, Dispersion (water waves), Energy (signal processing), Parametric statistics
Abstract

The calculation of free energy profiles is central in understanding differential enzymatic activity, for instance, involving chemical reactions that require QM-MM tools, ligand migration, and conformational rearrangements that can be modeled using classical potentials. The use of steered molecular dynamics (sMD) together with the Jarzynski equality is a popular approach in calculating free energy profiles. Here, we first briefly review the application of the Jarzynski equality to sMD simulations, then revisit the so-called stiff-spring approximation and the consequent expectation of Gaussian work distributions and, finally, reiterate the practical utility of the second-order cumulant expansion, as it coincides with the parametric maximum-likelihood estimator in this scenario. We illustrate this procedure using simulations of CO, both in aqueous solution and in a carbon nanotube as a model system for biologically relevant nanoheterogeneous environments. We conclude the use of the second-order cumulant expansion permits the use of faster pulling velocities in sMD simulations, without introducing bias due to large dispersion in the non-equilibrium work distribution.

Published
2018

20. Synchronous polyps predict metachronous colorectal lesions after curative resection of colorectal cancer

Author

Pozza, Anna, primary, Ruffolo, Cesare, additional, Fiorot, Alain, additional, Padoan, Luigi, additional, Erroi, Francesca, additional, Massani, Marco, additional, Caratozzolo, Ezio, additional, Bonariol, Luca, additional, Ferrara, Francesco, additional, Norberto, Lorenzo, additional, Castoro, Carlo, additional, Bassi, Nicolò, additional, and Scarpa, Marco, additional

Published
2016
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24. Report on a case of Rothmund-Thomson syndrome associated with esophageal stenosis

Author

Polese, Lino, Merigliano, Stefano, Mungo, B, Pennelli, Gianmaria, and Norberto, Lorenzo

Subjects
Adult, Young Adult, Adolescent, Hypothyroidism, Esophageal Stenosis, Rothmund-Thomson Syndrome, Humans, Infant, Female, Catheterization
Abstract

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis. While its incidence is unknown, approximately 300 cases have been reported in the literature. The syndrome typically presents with a characteristic facial rash (poikiloderma), its diagnostic hallmark, and heterogeneous clinical features including congenital skeletal abnormalities, sparse hair distribution, juvenile cataracts, and a predisposition to osteosarcoma. Gastrointestinal symptoms, such as pyloric stenosis, anal atresia, annular pancreas, and rectovaginal fistula, have also been reported sporadically. This is a report describing a patient diagnosed with RTS referred to us because of dysphagia caused by esophageal stenosis. Long-term results of endoscopic dilation are also presented.

Published
2011

26. SEMEIOTICA CHIRURGICA

Author

Lumachi, Franco, Norberto, Lorenzo, Angriman, Imerio, and Rigotti, Paolo

Published
2010

35. Considerazioni su 1200 endoarteriectomie carotidee

Author

Frego, Mauro, Bianchera, G, Scomparin, M. A., Konthotanassis, D, Pilon, F, DI CRISTOFARO, L, DE ZOLT, P, Bridda, A, Kertusha, X, Caruso, P, Angriman, Imerio, Norberto, Lorenzo, and Feltracco, P.

Subjects
vascular surgery
Published
2008

36. [Ruptured aneurysms of the abdominal aorta: from the First Aid to the Operating Room. Changing concepts]

Author

Frego, Mauro, Bianchera, G, Angriman, I, Norberto, Lorenzo, Pilon, F, Polese, Lino, Scarpa, M, Ruffolo, C, Corso, S, and DE ZOLT, P.

Subjects
Diagnosis, Differential, Male, Humans, Female, Aneurysm, Ruptured, Emergencies, Aortic Aneurysm, Abdominal
Abstract

Worldwide literature review from PubMed indicate that progress has been made in first aid assistance, diagnosis and treatment of ruptured abdominal aortic aneurysms, which led to a reduced operative mortality. Nevertheless, ruptured aneurysms may present atipically in about half of the cases, thus leading to an initially uncorrect diagnosis up to 25% of cases. Mean survival interval from onset of symptoms and death is 10-14 hours, thus indicating that time exists to consider the new imaging techniques in 80% of patients, particularly the TC multislice. This, when is strategically located close to the emergency or the operative room, can rapidly allow a correct diagnosis and provide an accurate morphological evaluation, thus enabling the surgeon to plan the most adequate treatment with open or endovascular repair.

Published
2007

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