481 results on '"Noor-E-Alam"'
Search Results
2. Clinical validation of peripheral blood mononuclear cell DNA methylation markers for accurate early detection of hepatocellular carcinoma in Asian patients
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Cheishvili, David, Wong, Chifat, Karim, Mohammad Mahbubul, Golam Kibria, Mohammad, Jahan, Nusrat, Chandra Das, Pappu, Khair Yousuf, Abul, Islam, Atikul, Chandra Das, Dulal, Noor-E-Alam, Sheikh Mohammad, Alam, Sarwar, Rahman, Mustafizur, Khan, Wasif A., Al-Mahtab, Mamun, and Szyf, Moshe
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- 2024
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3. Strategies for improving treatment retention for buprenorphine/naloxone for opioid use disorder: a qualitative study of issues and recommendations from prescribers
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Gary J. Young, Leonard D. Young, and Md. Noor-E-Alam
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Opioid use disorder ,Buprenorphine ,Qualitative research ,Substance use disorder ,Chronic disease management ,Medicine (General) ,R5-920 ,Social pathology. Social and public welfare. Criminology ,HV1-9960 - Abstract
Abstract Background Opioid use disorder (OUD) remains a significant public health issue as the number of opioid-related overdose deaths continues to reach new highs each year. Buprenorphine/Naloxone is a medication that has been shown to be highly effective for the treatment of OUD. However, the clinical management of patients on this medication is challenging as many patients discontinue treatment prematurely. We conducted a qualitative study focusing on experienced prescribers of buprenorphine to learn about what they believe are key challenges in prescribing this medication to patients with OUD and related strategies for improving treatment outcomes. Methods We conducted two rounds of interviews with 12 prescribers who were either trained as a primary care physician, nurse practitioner, or physician assistant. These prescribers were recruited from an academically-based treatment program, a community health center, and a commercial substance use disorder treatment facility. Interview data were coded and analyzed in accordance with a grounded theory approach. Results Key findings and related recommendations emerged for patient monitoring, integration of behavioral health with prescribing, patient volume requirements, and use of telehealth. Conclusion The interviews generated a number of recommendations for improving patient outcomes from buprenorphine treatment. Some of these recommendations can be implemented quite readily whereas others entail more substantial resources and time commitments.
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- 2024
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4. A Nationwide Multi-Location Multi-Resource Stochastic Programming Based Energy Planning Framework
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Al-Lawati, Razan A. H., Faiz, Tasnim Ibn, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
The global increase in energy consumption and demand has forced many countries to transition into including more diverse energy sources in their electricity market. To efficiently utilize the available fuel resources, all energy sources must be optimized simultaneously. However, the inherent variability in variable renewable energy generators makes deterministic models ineffective. On the other hand, comprehensive stochastic models, including all sources of generation across a nation, can become computationally intractable. This work proposes a comprehensive national energy planning framework from a policymaker's perspective, which is generalizable to any country, region, or any group of countries in energy trade agreements. Given its relative land area and energy consumption globally, the United States is selected as a case study. A two-stage stochastic programming approach is adopted, and a scenario-based Benders decomposition modeling approach is employed to achieve computational efficiency for the large-scale model. Data is obtained from the U.S. Energy Information Administration's online data collection. Scenarios for the uncertain parameters are developed using a k-means clustering algorithm. Various cases are compared from a financial perspective to inform policymaking by identifying implementable cost-reduction strategies. The findings underscore the importance of promoting resource coordination and demonstrate the impact of increasing interchange and renewable energy capacity on overall gains. Moreover, the study highlights the value of stochastic optimization modeling compared to deterministic modeling to make energy planning decisions.
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- 2023
5. A review on hybrid energy generation: Cow dung biogas, solar thermal and kinetic energy integration for power production
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Amam Hossain Bagdadee, Argho Moy Maitraya, Ariful Islam, and Md. Noor E Alam Siddique
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Hybrid energy system ,Cow dung biogas ,Solar thermal ,Kinetic energy ,Sustainability ,Environmental technology. Sanitary engineering ,TD1-1066 ,Building construction ,TH1-9745 - Abstract
The growing global demand for clean and sustainable energy sources has sparked interest in hybrid energy systems that combine multiple renewable energy technologies. This review paper explores the integration of cow dung biogas, solar thermal, and kinetic energy for power production. The synergistic utilization of these energy sources holds significant potential for addressing the energy challenges faced by various communities. This paper provides an overview of each technology, discusses the benefits and challenges of integration, and highlights successful case studies. Furthermore, it discusses this hybrid energy generation system's potential future developments and implications.
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- 2025
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6. Clinical validation of peripheral blood mononuclear cell DNA methylation markers for accurate early detection of hepatocellular carcinoma in Asian patients
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David Cheishvili, Chifat Wong, Mohammad Mahbubul Karim, Mohammad Golam Kibria, Nusrat Jahan, Pappu Chandra Das, Abul Khair Yousuf, Atikul Islam, Dulal Chandra Das, Sheikh Mohammad Noor-E-Alam, Sarwar Alam, Mustafizur Rahman, Wasif A. Khan, Mamun Al-Mahtab, and Moshe Szyf
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Medicine - Abstract
Abstract Background Hepatocellular carcinoma (HCC), a leading cause of cancer-related deaths globally, poses significant challenges in early detection. Improved diagnostic accuracy can drastically influence patient outcomes, emphasizing the need for innovative, non-invasive biomarkers. Methods: This study utilized a cohort of 402 participants, including healthy controls, chronic hepatitis patients, and HCC patients from Bangladesh, to evaluate DNA methylation signatures in peripheral blood mononuclear cells (PBMC). We performed targeted next-generation sequencing on selected genes previously identified to assess their methylation dynamics. The development of M8 and M4 scores was based on these dynamics, using Receiver Operating Characteristic (ROC) analysis to determine their effectiveness in detecting early-stage HCC alongside existing markers such as epiLiver and alpha-fetoprotein (AFP). Results: Integration of M8 and M4 scores with epiLiver and AFP significantly enhances diagnostic sensitivity for early-stage HCC. The M4+epiLiver score achieves a sensitivity of 79.4% in Stage A HCC, while combining M4 with AFP increases sensitivity to 88.2–95.7% across all stages, indicating a superior diagnostic performance compared to each marker used alone. Conclusions: Our study confirms that combining gene methylation profiles with established diagnostic markers substantially improves the sensitivity of detecting early-stage HCC. This integrated diagnostic approach holds promise for advancing non-invasive cancer diagnostics, potentially leading to earlier treatment interventions and improved survival rates for high-risk patients.
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- 2024
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7. A Robust Optimization Framework for Two-Echelon Vehicle and UAV Routing for Post-Disaster Humanitarian Logistics Operations
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Faiz, Tasnim Ibn, Vogiatzis, Chrysafis, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
Providing first aid and other supplies (e.g., epi-pens, medical supplies, dry food, water) during and after a disaster is always challenging. The complexity of these operations increases when the transportation, power, and communications networks fail, leaving people stranded and unable to communicate their locations and needs. The advent of emerging technologies like uncrewed autonomous vehicles can help humanitarian logistics providers reach otherwise stranded populations after transportation network failures. However, due to the failures in telecommunication infrastructure, demand for emergency aid can become uncertain. To address the challenges of delivering emergency aid to trapped populations with failing infrastructure networks, we propose a novel robust computational framework for a two-echelon vehicle routing problem that uses uncrewed autonomous vehicles, or drones, for the deliveries. We formulate the problem as a two-stage robust optimization model to handle demand uncertainty. Then, we propose a column-and-constraint generation approach for worst-case demand scenario generation for a given set of truck and drone routes. Moreover, we develop a decomposition scheme inspired by the column generation approach to heuristically generate drone routes for a set of demand scenarios. Finally, we combine the heuristic decomposition scheme within the column-andconstraint generation approach to determine robust routes for both trucks and drones, the time that affected communities are served, and the quantities of aid materials delivered. To validate our proposed computational framework, we use a simulated dataset that aims to recreate emergency aid requests in different areas of Puerto Rico after Hurricane Maria in 2017.
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- 2022
8. Optimizing Return and Secure Disposal of Prescription Opioids to Reduce the Diversion to Secondary Users and Black Market
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Hasan, Md Mahmudul, Faiz, Tasnim Ibn, Modestino, Alicia Sasser, Young, Gary J., and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
Opioid Use Disorder (OUD) has reached an epidemic level in the US. Diversion of unused prescription opioids to secondary users and black market significantly contributes to the abuse and misuse of these highly addictive drugs, leading to the increased risk of OUD and accidental opioid overdose within communities. Hence, it is critical to design effective strategies to reduce the non-medical use of opioids that can occur via diversion at the patient level. In this paper, we aim to address this critical public health problem by designing strategies for the return and safe disposal of unused prescription opioids. We propose a data-driven optimization framework to determine the optimal incentive disbursement plans and locations of easily accessible opioid disposal kiosks to motivate prescription opioid users of diverse profiles in returning their unused opioids. We develop a Mixed-Integer Non-Linear Programming (MINLP) model to solve the decision problem, followed by a reformulation scheme using Benders Decomposition that results in a computationally efficient solution. We present a case study to show the benefits and usability of the model using a dataset created from Massachusetts All Payer Claims Data (MA APCD). Our proposed model allows the policymakers to estimate and include a penalty cost considering the economic and healthcare burden associated with prescription opioid diversion. Our numerical experiments demonstrate the ability of model and usefulness in determining optimal locations of opioid disposal kiosks and incentive disbursement plans for maximizing the disposal of unused opioids. The proposed optimization framework offers various trade-off strategies that can help government agencies design pragmatic policies for reducing the diversion of unused prescription opioids.
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- 2022
9. A review on hybrid energy generation: Cow dung biogas, solar thermal and kinetic energy integration for power production
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Bagdadee, Amam Hossain, Maitraya, Argho Moy, Islam, Ariful, and Siddique, Md. Noor E Alam
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- 2025
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10. A Two-Stage Feature Selection Approach for Robust Evaluation of Treatment Effects in High-Dimensional Observational Data
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Islam, Md Saiful, Shikalgar, Sahil, and Noor-E-Alam, Md.
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Statistics - Methodology - Abstract
A Randomized Control Trial (RCT) is considered as the gold standard for evaluating the effect of any intervention or treatment. However, its feasibility is often hindered by ethical, economical, and legal considerations, making observational data a valuable alternative for drawing causal conclusions. Nevertheless, healthcare observational data presents a difficult challenge due to its high dimensionality, requiring careful consideration to ensure unbiased, reliable, and robust causal inferences. To overcome this challenge, in this study, we propose a novel two-stage feature selection technique called, Outcome Adaptive Elastic Net (OAENet), explicitly designed for making robust causal inference decisions using matching techniques. OAENet offers several key advantages over existing methods: superior performance on correlated and high-dimensional data compared to the existing methods and the ability to select specific sets of variables (including confounders and variables associated only with the outcome). This ensures robustness and facilitates an unbiased estimate of the causal effect. Numerical experiments on simulated data demonstrate that OAENet significantly outperforms state-of-the-art methods by either producing a higher-quality estimate or a comparable estimate in significantly less time. To illustrate the applicability of OAENet, we employ large-scale US healthcare data to estimate the effect of Opioid Use Disorder (OUD) on suicidal behavior. When compared to competing methods, OAENet closely aligns with existing literature on the relationship between OUD and suicidal behavior. Performance on both simulated and real-world data highlights that OAENet notably enhances the accuracy of estimating treatment effects or evaluating policy decision-making with causal inference.
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- 2021
11. Self-help groups and opioid use disorder treatment: An investigation using a machine learning-assisted robust causal inference framework
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Shikalgar, Sahil, Weiner, Scott G., Young, Gary J., and Noor-E-Alam, Md.
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- 2024
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12. An explainable machine learning framework for predicting the risk of buprenorphine treatment discontinuation for opioid use disorder among commercially insured individuals
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Al Faysal, Jabed, Noor-E-Alam, Md., Young, Gary J., Lo-Ciganic, Wei-Hsuan, Goodin, Amie J., Huang, James L., Wilson, Debbie L., Park, Tae Woo, and Hasan, Md Mahmudul
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- 2024
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13. Internet of Things-Driven Precision in Fish Farming: A Deep Dive into Automated Temperature, Oxygen, and pH Regulation
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Md. Naymul Islam Nayoun, Syed Akhter Hossain, Karim Mohammed Rezaul, Kazy Noor e Alam Siddiquee, Md. Shabiul Islam, and Tajnuva Jannat
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smart fish farm ,pH sensor ,IoT ,temperature sensor ,cloud monitoring ,automatic controlling ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
The research introduces a revolutionary Internet of Things (IoT)-based system for fish farming, designed to significantly enhance efficiency and cost-effectiveness. By integrating the NodeMcu12E ESP8266 microcontroller, this system automates the management of critical water quality parameters such as pH, temperature, and oxygen levels, essential for fostering optimal fish growth conditions and minimizing mortality rates. The core of this innovation lies in its intelligent monitoring and control mechanism, which not only supports accelerated fish development but also ensures the robustness of the farming process through automated adjustments whenever the monitored parameters deviate from desired thresholds. This smart fish farming solution features an Arduino IoT cloud-based framework, offering a user-friendly web interface that enables fish farmers to remotely monitor and manage their operations from any global location. This aspect of the system emphasizes the importance of efficient information management and the transformation of sensor data into actionable insights, thereby reducing the need for constant human oversight and significantly increasing operational reliability. The autonomous functionality of the system is a key highlight, designed to persist in adjusting the environmental conditions within the fish farm until the optimal parameters are restored. This capability greatly diminishes the risks associated with manual monitoring and adjustments, allowing even those with limited expertise in aquaculture to achieve high levels of production efficiency and sustainability. By leveraging data-driven technologies and IoT innovations, this study not only addresses the immediate needs of the fish farming industry but also contributes to solving the broader global challenge of protein production. It presents a scalable and accessible approach to modern aquaculture, empowering stakeholders to maximize output and minimize risks associated with fish farming, thereby paving the way for a more sustainable and efficient future in the global food supply.
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- 2024
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14. Computational approaches for solving two-echelon vehicle and UAV routing problems for post-disaster humanitarian operations
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Faiz, Tasnim Ibn, Vogiatzis, Chrysafis, and Noor-E-Alam, Md.
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- 2024
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15. Two-Stage Stochastic Optimization Frameworks to Aid in Decision-Making Under Uncertainty for Variable Resource Generators Participating in a Sequential Energy Market
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Al-Lawati, Razan A. H., Crespo-Vazquez, Jose L., Faiz, Tasnim Ibn, Fang, Xin, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
Decisions for a variable renewable resource generators commitment in the energy market are typically made in advance when little information is obtainable about wind availability and market prices. Much research has been published recommending various frameworks for addressing this issue. However, these frameworks are limited as they do not consider all markets a producer can participate in. Moreover, current stochastic programming models do not allow for uncertainty data to be updated as more accurate information becomes available. This work proposes two decision-making frameworks for a wind energy generator participating in day-ahead, intraday, reserve, and balancing markets. The first framework is a two-stage stochastic convex optimization approach, where both scenario-independent and scenario-dependent decisions are made concurrently. The second framework is a series of four two-stage stochastic optimization models wherein the results from each model feed into each subsequent model allowing for scenarios to be updated as more information becomes available to the decision-maker. In the simulation experiments, the multi-phase framework performs better than the single-phase in every run, and results in an average profit increase of 7%. The proposed optimization frameworks aid in better decision-making while addressing uncertainty related to variable resource generators and maximize the return on investment.
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- 2020
16. Stochastic Steepest Descent Methods for Linear Systems: Greedy Sampling & Momentum
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Morshed, Md Sarowar, Ahmad, Sabbir, and Noor-E-Alam, Md
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Mathematics - Numerical Analysis - Abstract
Recently proposed adaptive Sketch & Project (SP) methods connect several well-known projection methods such as Randomized Kaczmarz (RK), Randomized Block Kaczmarz (RBK), Motzkin Relaxation (MR), Randomized Coordinate Descent (RCD), Capped Coordinate Descent (CCD), etc. into one framework for solving linear systems. In this work, we first propose a Stochastic Steepest Descent (SSD) framework that connects SP methods with the well-known Steepest Descent (SD) method for solving positive-definite linear system of equations. We then introduce two greedy sampling strategies in the SSD framework that allow us to obtain algorithms such as Sampling Kaczmarz Motzkin (SKM), Sampling Block Kaczmarz (SBK), Sampling Coordinate Descent (SCD), etc. In doing so, we generalize the existing sampling rules into one framework and develop an efficient version of SP methods. Furthermore, we incorporated the Polyak momentum technique into the SSD method to accelerate the resulting algorithms. We provide global convergence results for both the SSD method and the momentum induced SSD method. Moreover, we prove $\mathcal{O}(\frac{1}{k})$ convergence rate for the Cesaro average of iterates generated by both methods. By varying parameters in the SSD method, we obtain classical convergence results of the SD method as well as the SP methods as special cases. We design computational experiments to demonstrate the performance of the proposed greedy sampling methods as well as the momentum methods. The proposed greedy methods significantly outperform the existing methods for a wide variety of datasets such as random test instances as well as real-world datasets (LIBSVM, sparse datasets from matrix market collection). Finally, the momentum algorithms designed in this work accelerate the algorithmic performance of the SSD methods.
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- 2020
17. A Computational Framework for Solving Nonlinear Binary OptimizationProblems in Robust Causal Inference
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Islam, Md Saiful, Morshed, Md Sarowar, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control ,Computer Science - Artificial Intelligence ,Computer Science - Discrete Mathematics ,Statistics - Applications - Abstract
Identifying cause-effect relations among variables is a key step in the decision-making process. While causal inference requires randomized experiments, researchers and policymakers are increasingly using observational studies to test causal hypotheses due to the wide availability of observational data and the infeasibility of experiments. The matching method is the most used technique to make causal inference from observational data. However, the pair assignment process in one-to-one matching creates uncertainty in the inference because of different choices made by the experimenter. Recently, discrete optimization models are proposed to tackle such uncertainty. Although a robust inference is possible with discrete optimization models, they produce nonlinear problems and lack scalability. In this work, we propose greedy algorithms to solve the robust causal inference test instances from observational data with continuous outcomes. We propose a unique framework to reformulate the nonlinear binary optimization problems as feasibility problems. By leveraging the structure of the feasibility formulation, we develop greedy schemes that are efficient in solving robust test problems. In many cases, the proposed algorithms achieve global optimal solutions. We perform experiments on three real-world datasets to demonstrate the effectiveness of the proposed algorithms and compare our result with the state-of-the-art solver. Our experiments show that the proposed algorithms significantly outperform the exact method in terms of computation time while achieving the same conclusion for causal tests. Both numerical experiments and complexity analysis demonstrate that the proposed algorithms ensure the scalability required for harnessing the power of big data in the decision-making process.
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- 2020
18. Sketch & Project Methods for Linear Feasibility Problems: Greedy Sampling & Momentum
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Morshed, Md Sarowar and Noor-E-Alam, Md.
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Mathematics - Numerical Analysis ,Mathematics - Optimization and Control - Abstract
We develop two greedy sampling rules for the Sketch & Project method for solving linear feasibility problems. The proposed greedy sampling rules generalize the existing max-distance sampling rule and uniform sampling rule and generate faster variants of Sketch & Project methods. We also introduce greedy capped sampling rules that improve the existing capped sampling rules. Moreover, we incorporate the so-called heavy ball momentum technique to the proposed greedy Sketch & Project method. By varying the parameters such as sampling rules, sketching vectors; we recover several well-known algorithms as special cases, including Randomized Kaczmarz (RK), Motzkin Relaxation (MR), Sampling Kaczmarz Motzkin (SKM). We also obtain several new methods such as Randomized Coordinate Descent, Sampling Coordinate Descent, Capped Coordinate Descent, etc. for solving linear feasibility problems. We provide global linear convergence results for both the basic greedy method and the greedy method with momentum. Under weaker conditions, we prove $\mathcal{O}(\frac{1}{k})$ convergence rate for the Cesaro average of sequences generated by both methods. We extend the so-called certificate of feasibility result for the proposed momentum method that generalizes several existing results. To back up the proposed theoretical results, we carry out comprehensive numerical experiments on randomly generated test instances as well as sparse real-world test instances. The proposed greedy sampling methods significantly outperform the existing sampling methods. And finally, the momentum variants designed in this work extend the computational performance of the Sketch & Project methods for all of the sampling rules.
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- 2020
19. Heavy Ball Momentum Induced Sampling Kaczmarz Motzkin Methods for Linear Feasibility Problems
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Morshed, Md Sarowar and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
The recently proposed Sampling Kaczmarz Motzkin (SKM) algorithm performs well in comparison with the state-of-the-art methods in solving large-scale Linear Feasibility (LF) problems. To explore the concept of momentum in the context of solving LF problems, in this work, we propose a momentum induced algorithm called Momentum Sampling Kaczmarz Motzkin (MSKM). The MSKM algorithm is developed by integrating the heavy ball momentum to the SKM algorithm. We provide a rigorous convergence analysis of the proposed MSKM algorithm from which we obtain convergence results of several Kaczmarz type methods for solving LF problems. Moreover, under somewhat weaker conditions, we establish a sub-linear convergence rate for the so-called Cesaro average of the sequence generated by the MSKM algorithm. We then back up the theoretical results via thorough numerical experiments on artificial and real datasets. For a fair comparison, we test our proposed method in comparison with the SKM method on a wide variety of test instances: 1) randomly generated instances, 2) Netlib LPs and 3) linear classification test instances. We also compare the proposed method with the traditional Interior Point Method (IPM) and Active Set Method (ASM) on Netlib LPs. The proposed momentum induced algorithm significantly outperforms the basic SKM method (with no momentum) on all of the considered test instances. Furthermore, the proposed algorithm also performs well in comparison with IPM and ASM algorithms. Finally, we propose a stochastic version of the MSKM algorithm called Stochastic-Momentum Sampling Kaczmarz Motzkin (SSKM) to better handle large-scale real-world data. We conclude our work with a rigorous theoretical convergence analysis of the proposed SSKM algorithm., Comment: arXiv admin note: text overlap with arXiv:2002.07321
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- 2020
20. Sampling Kaczmarz Motzkin Method for Linear Feasibility Problems: Generalization & Acceleration
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Morshed, Md Sarowar, Islam, Md Saiful, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
Randomized Kaczmarz (RK), Motzkin Method (MM) and Sampling Kaczmarz Motzkin (SKM) algorithms are commonly used iterative techniques for solving a system of linear inequalities (i.e., $Ax \leq b$). As linear systems of equations represent a modeling paradigm for solving many optimization problems, these randomized and iterative techniques are gaining popularity among researchers in different domains. In this work, we propose a Generalized Sampling Kaczmarz Motzkin (GSKM) method that unifies the iterative methods into a single framework. In addition to the general framework, we propose a Nesterov type acceleration scheme in the SKM method called as Probably Accelerated Sampling Kaczmarz Motzkin (PASKM). We prove the convergence theorems for both GSKM and PASKM algorithms in the $L_2$ norm perspective with respect to the proposed sampling distribution. Furthermore, we prove sub-linear convergence for the Cesaro average of iterates for the proposed GSKM and PASKM algorithms.From the convergence theorem of the GSKM algorithm, we find the convergence results of several well-known algorithms like the Kaczmarz method, Motzkin method and SKM algorithm. We perform thorough numerical experiments using both randomly generated and real-world (classification with support vector machine and Netlib LP) test instances to demonstrate the efficiency of the proposed methods. We compare the proposed algorithms with SKM, Interior Point Method (IPM) and Active Set Method (ASM) in terms of computation time and solution quality. In the majority of the problem instances, the proposed generalized and accelerated algorithms significantly outperform the state-of-the-art methods.
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- 2020
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21. A high-throughput test enables specific detection of hepatocellular carcinoma
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David Cheishvili, Chifat Wong, Mohammad Mahbubul Karim, Mohammad Golam Kibria, Nusrat Jahan, Pappu Chandra Das, Md. Abul Khair Yousuf, Md. Atikul Islam, Dulal Chandra Das, Sheikh Mohammad Noor-E-Alam, Moshe Szyf, Sarwar Alam, Wasif A. Khan, and Mamun Al Mahtab
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Science - Abstract
Abstract High-throughput tests for early cancer detection can revolutionize public health and reduce cancer morbidity and mortality. Here we show a DNA methylation signature for hepatocellular carcinoma (HCC) detection in liquid biopsies, distinct from normal tissues and blood profiles. We developed a classifier using four CpG sites, validated in TCGA HCC data. A single F12 gene CpG site effectively differentiates HCC samples from other blood samples, normal tissues, and non-HCC tumors in TCGA and GEO data repositories. The markers were validated in a separate plasma sample dataset from HCC patients and controls. We designed a high-throughput assay using next-generation sequencing and multiplexing techniques, analyzing plasma samples from 554 clinical study participants, including HCC patients, non-HCC cancers, chronic hepatitis B, and healthy controls. HCC detection sensitivity was 84.5% at 95% specificity and 0.94 AUC. Implementing this assay for high-risk individuals could significantly decrease HCC morbidity and mortality.
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- 2023
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22. Computational Approaches for Solving Two-Echelon Vehicle and UAV Routing Problems for Post-Disaster Humanitarian Operations
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Faiz, Tasnim Ibn, Vogiatzis, Chrysafis, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
Humanitarian logistics service providers have two major responsibilities immediately after a disaster: locating trapped people and routing aid to them. These difficult operations are further hindered by failures in the transportation and telecommunications networks, which are often rendered unusable by the disaster at hand. In this work, we propose a two-echelon vehicle routing framework for performing these operations using aerial uncrewed autonomous vehicles (UAVs or drones) to address the issues associated with these failures. In our proposed framework, we assume that ground vehicles cannot reach the trapped population directly, but they can only transport drones from a depot to some intermediate locations. The drones launched from these locations serve to both identify demands for medical and other aids (e.g., epi-pens, medical supplies, dry food, water) and make deliveries to satisfy them. Specifically, we present a decision framework, in which the resulting optimization problem is formulated as a two-echelon vehicle routing problem with trucks as the first echelon vehicles and for the second echelon vehicles, we consider two types of drones. Hotspot drones have the capability of providing a cell phone and internet reception and hence are used to capture demands. Delivery drones are subsequently employed to satisfy the observed demand. To handle demand uncertainty, we decompose the decision problem into two stages: providing telecommunications capabilities in the first stage thereby capturing demand precisely, and satisfying the resulting demands in the second stage. To solve the resulting models, we propose efficient computational approaches by designing a decomposition algorithm with column generation (CG)-based heuristics to identify optimal drone routes.
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- 2020
23. Resilient Supplier Selection in Logistics 4.0 with Heterogeneous Information
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Hassan, Md Mahmudul, Jiang, Dizuo, Ullah, A. M. M. Sharif, and Noor-E-Alam, Md.
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Computer Science - Artificial Intelligence - Abstract
Supplier selection problem has gained extensive attention in the prior studies. However, research based on Fuzzy Multi-Attribute Decision Making (F-MADM) approach in ranking resilient suppliers in logistic 4 is still in its infancy. Traditional MADM approach fails to address the resilient supplier selection problem in logistic 4 primarily because of the large amount of data concerning some attributes that are quantitative, yet difficult to process while making decisions. Besides, some qualitative attributes prevalent in logistic 4 entail imprecise perceptual or judgmental decision relevant information, and are substantially different than those considered in traditional suppler selection problems. This study develops a Decision Support System (DSS) that will help the decision maker to incorporate and process such imprecise heterogeneous data in a unified framework to rank a set of resilient suppliers in the logistic 4 environment. The proposed framework induces a triangular fuzzy number from large-scale temporal data using probability-possibility consistency principle. Large number of non-temporal data presented graphically are computed by extracting granular information that are imprecise in nature. Fuzzy linguistic variables are used to map the qualitative attributes. Finally, fuzzy based TOPSIS method is adopted to generate the ranking score of alternative suppliers. These ranking scores are used as input in a Multi-Choice Goal Programming (MCGP) model to determine optimal order allocation for respective suppliers. Finally, a sensitivity analysis assesses how the Suppliers Cost versus Resilience Index (SCRI) changes when differential priorities are set for respective cost and resilience attributes.
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- 2019
24. A Big Data Analytics Framework to Predict the Risk of Opioid Use Disorder
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Hasan, Md Mahmudul, Noor-E-Alam, Md., Patel, Mehul Rakeshkumar, Modestino, Alicia Sasser, Sanchez, Leon D., and Young, Gary
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Statistics - Applications ,Computer Science - Computers and Society ,Quantitative Biology - Quantitative Methods - Abstract
Overdose related to prescription opioids have reached an epidemic level in the US, creating an unprecedented national crisis. This has been exacerbated partly due to the lack of tools for physicians to help predict the risk of whether a patient will develop opioid use disorder. Little is known about how machine learning can be applied to a big-data platform to ensure an informed, sustained and judicious prescribing of opioids, in particular for commercially insured population. This study explores Massachusetts All Payer Claims Data, a de-identified healthcare dataset, and proposes a machine learning framework to examine how na\"ive users develop opioid use disorder. We perform several feature selections techniques to identify influential demographic and clinical features associated with opioid use disorder from a class imbalanced analytic sample. We then compare the predictive power of four well-known machine learning algorithms: Logistic Regression, Random Forest, Decision Tree, and Gradient Boosting to predict the risk of opioid use disorder. The study results show that the Random Forest model outperforms the other three algorithms while determining the features, some of which are consistent with prior clinical findings. Moreover, alongside the higher predictive accuracy, the proposed framework is capable of extracting some risk factors that will add significant knowledge to what is already known in the extant literature. We anticipate that this study will help healthcare practitioners improve the current prescribing practice of opioids and contribute to curb the increasing rate of opioid addiction and overdose.
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- 2019
25. Robust policy evaluation from large-scale observational studies
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Islam, Md Saiful, Morshed, Md Sarowar, Young, Gary J., and Noor-E-Alam, Md.
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Statistics - Methodology ,Mathematics - Optimization and Control - Abstract
Under current policy decision making paradigm, we make or evaluate a policy decision by intervening different socio-economic parameters and analyzing the impact of those interventions. This process involves identifying the causal relation between interventions and outcomes. Matching method is one of the popular techniques to identify such causal relations. However, in one-to-one matching, when a treatment or control unit has multiple pair assignment options with similar match quality, different matching algorithms often assign different pairs. Since, all the matching algorithms assign pair without considering the outcomes, it is possible that with same data and same hypothesis, different experimenters can make different conclusions. This problem becomes more prominent in case of large-scale observational studies. Recently, a robust approach is proposed to tackle the uncertainty which uses discrete optimization techniques to explore all possible assignments. Though optimization techniques are very efficient in its own way, they are not scalable to big data. In this work, we consider causal inference testing with binary outcomes and propose computationally efficient algorithms that are scalable to large-scale observational studies. By leveraging the structure of the optimization model, we propose a robustness condition which further reduces the computational burden. We validate the efficiency of the proposed algorithms by testing the causal relation between Hospital Readmission Reduction Program (HRRP) and readmission to different hospital (non-index readmission) on the State of California Patient Discharge Database from 2010 to 2014. Our result shows that HRRP has a causal relation with the increase in non-index readmission and the proposed algorithms proved to be highly scalable in testing causal relations from large-scale observational studies.
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- 2019
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26. Accelerated Sampling Kaczmarz Motzkin Algorithm for The Linear Feasibility Problem
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Morshed, Md Sarowar, Islam, Md Saiful, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
The Sampling Kaczmarz Motzkin (SKM) algorithm is a generalized method for solving large scale linear systems of inequalities. Having its root in the relaxation method of Agmon, Schoenberg, and Motzkin and the randomized Kaczmarz method, SKM outperforms the state of the art methods in solving large-scale Linear Feasibility (LF) problems. Motivated by SKM's success, in this work, we propose an Accelerated Sampling Kaczmarz Motzkin (ASKM) algorithm which achieves better convergence compared to the standard SKM algorithm on ill conditioned problems. We provide a thorough convergence analysis for the proposed accelerated algorithm and validate the results with various numerical experiments. We compare the performance and effectiveness of ASKM algorithm with SKM, Interior Point Method (IPM) and Active Set Method (ASM) on randomly generated instances as well as Netlib LPs. In most of the test instances, the proposed ASKM algorithm outperforms the other state of the art methods., Comment: Journal of Global Optimization, Oct 2019
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- 2019
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27. Optimizing return and secure disposal of prescription opioids to reduce the diversion to secondary users and black market
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Hasan, Md Mahmudul, Faiz, Tasnim Ibn, Modestino, Alicia Sasser, Young, Gary J., and Noor-E-Alam, Md
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- 2023
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28. Determining the role of land resource, cropping and management practices in soil organic carbon status of rice-based cropping systems
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Siddique, Md. Noor E. Alam, Lobry de Bruyn, Lisa A., Osanai, Yui, and Guppy, Chris N.
- Published
- 2023
- Full Text
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29. Corrigendum: Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh
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Md. Aminul Islam, Mohammad Nayeem Hasan, Tanvir Ahammed, Aniqua Anjum, Ananya Majumder, M. Noor-E-Alam Siddiqui, Sanjoy Kumar Mukharjee, Khandokar Fahmida Sultana, Sabrin Sultana, Md. Jakariya, Prosun Bhattacharya, Samuel Asumadu Sarkodie, Kuldeep Dhama, Jubayer Mumin, and Firoz Ahmed
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developing countries ,solid fuels ,clean fuels ,under-five children ,acute respiratory infection (ARI) ,Public aspects of medicine ,RA1-1270 - Published
- 2023
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30. Restoring Soil Fertility, Productivity and Biodiversity through Participatory Agroforestry: Evidence from Madhupur Sal Forest, Bangladesh
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Kazi Kamrul Islam, Md. Saifullah, M. Golam Mahboob, Kazi Noor-E-Alam Jewel, S. M. Kamran Ashraf, and Kimihiko Hyakumura
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soil nutrients ,yield ,cost–benefit ,land equivalent ratio ,species richness ,agroforestry ,Agriculture - Abstract
Species diversity and soil quality are deteriorating due to continuous disturbances in ecosystems caused by human interference. However, agroforestry is considered a good approach to minimizing environmental problems. Therefore, the objective of this study was to determine the impacts of participatory agroforestry on restoring soil fertility, farm productivity and biodiversity in the degraded Madhupur Sal forest of Bangladesh. The study purposefully selected 40 common agroforestry programs in Madhupur Sal forest for the collection of soil and plant data from 2020 to 2023. Agroforestry programs have improved soil organic matter, soil carbon, pH, and available N, P and K content to a substantial degree and protected soil degradation, enhancing yield. The soil improvement index represents the potentiality of agroforestry in restoring soil nutrients and carbon in the form of organic matter, which is an important indicator for carbon sequestration and mitigating the impacts of climate change. The resultant cost–benefit and land equivalent ratios were steadily higher, which corroborates the greater productivity and profitability of agroforestry compared to monoculture systems. In contrast, agroforestry restored 31 plant species, opening up opportunities for restoring plant species in the threatened forest ecosystem. Therefore, this study recommended selecting appropriate site-specific species for managing agroforestry and restoring ecosystems.
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- 2024
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31. A robust approach to quantifying uncertainty in matching problems of causal inference
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Morucci, Marco, Noor-E-Alam, Md., and Rudin, Cynthia
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Statistics - Methodology - Abstract
Unquantified sources of uncertainty in observational causal analyses can break the integrity of the results. One would never want another analyst to repeat a calculation with the same dataset, using a seemingly identical procedure, only to find a different conclusion. However, as we show in this work, there is a typical source of uncertainty that is essentially never considered in observational causal studies: the choice of match assignment for matched groups, that is, which unit is matched to which other unit before a hypothesis test is conducted. The choice of match assignment is anything but innocuous, and can have a surprisingly large influence on the causal conclusions. Given that a vast number of causal inference studies test hypotheses on treatment effects after treatment cases are matched with similar control cases, we should find a way to quantify how much this extra source of uncertainty impacts results. What we would really like to be able to report is that \emph{no matter} which match assignment is made, as long as the match is sufficiently good, then the hypothesis test result still holds. In this paper, we provide methodology based on discrete optimization to create robust tests that explicitly account for this possibility. We formulate robust tests for binary and continuous data based on common test statistics as integer linear programs solvable with common methodologies. We study the finite-sample behavior of our test statistic in the discrete-data case. We apply our methods to simulated and real-world datasets and show that they can produce useful results in practical applied settings.
- Published
- 2018
32. A Distance Measuring Algorithm for Location Analysis
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Ouyang, Ruilin, Ma, Dinghao, Morshed, M. S., and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
Approximating distance is one of the key challenge in a facility location problem. Several algorithms have been proposed, however, none of them focused on estimating distance between two concave regions. In this work, we present an algorithm to estimate the distance between two irregular regions of a facility location problem. The proposed algorithm can identify the distance between concave shape regions. We also discuss some relevant properties of the proposed algorithm. A distance-sensitive capacity location model is introduced to test the algorithm. Moreover, sSeveral special geometric cases are discussed to show the advantages and insights of the algorithm.
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- 2018
33. A Possibility Distribution Based Multi-Criteria Decision Algorithm for Resilient Supplier Selection Problems
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Jiang, Dizuo, Hassan, Md Mahmudul, Faiz, Tasnim Ibn, and Noor-E-Alam, Md.
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Computer Science - Artificial Intelligence ,Mathematics - Optimization and Control - Abstract
Thus far, limited research has been performed on resilient supplier selection - a problem that requires simultaneous consideration of a set of numerical and linguistic evaluation criteria, which are substantially different from traditional supplier selection problem. Essentially, resilient supplier selection entails key sourcing decision for an organization to gain competitive advantage. In the presence of multiple conflicting evaluation criteria, contradicting decision makers, and imprecise decision relevant information (DRI), this problem becomes even more difficult to solve with the classical optimization approaches. However, prior research focusing on MCDA based supplier selection problem has been lacking in the ability to provide a seamless integration of numerical and linguistic evaluation criteria along with the consideration of multiple decision makers. To address these challenges, we present a comprehensive decision-making framework for ranking a set of suppliers from resiliency perspective. The proposed algorithm is capable of leveraging imprecise and aggregated DRI obtained from crisp numerical assessments and reliability adjusted linguistic appraisals from a group of decision makers. We adapt two popular tools - Single Valued Neutrosophic Sets (SVNS) and Interval-valued fuzzy sets (IVFS), and for the first time extend them to incorporate both crisp and linguistic evaluations in a group decision making platform to obtain aggregated SVNS and IVFS decision matrix. This information is then used to rank the resilient suppliers by using TOPSIS method. We present a case study to illustrate the mechanism of the proposed algorithm.
- Published
- 2018
34. A Column Generation Algorithm for Vehicle Scheduling and Routing Problems
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Faiz, Tasnim Ibn, Vogiatzis, Chrysafis, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
During natural or anthropogenic disasters, humanitarian organizations face a series of time-sensitive tasks. One of the tasks involves picking up critical resources (e.g., first aid kits, blankets, water) from warehouses and delivering them to the affected people. To successfully deliver these items to the people in need, the organization needs to make decisions that range from the quick acquisition of vehicles from the local market, to the preparation of pickup and delivery schedules and vehicle routes. During crises, the supply of vehicles is often limited, their acquisition cost is steep, and special rental periods are imposed. At the same time, the affected area needs the aid materials as fast as possible, and deliveries must be made within due time. Therefore, it is imperative that the decisions of acquiring, scheduling, and routing of vehicles are made optimally and quickly. In this paper, we consider a variant of a truckload open vehicle routing problem with time windows, which is suitable for modeling vehicle routing operations during a humanitarian crisis. We present two integer linear programming models to formulate the problem, with the first one being an arc-based mixed integer linear programming model. The second model is a path-based integer linear programming model, for which we design two fast path generation algorithms. The first model is solved exactly using the commercial solver, while we propose to solve the second model within a column generation framework. Finally, we perform numerical experiments and compare the results obtained from the two models. We show that the path-based model, when solved with our column generation algorithm, outperforms the arc-based model in terms of solution time without sacrificing the solution quality.
- Published
- 2018
35. A Primal-Dual Interior Point Method for a Novel Type-2 Second Order Cone Optimization Problem
- Author
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Morshed, Md Sarowar, Vogiatzis, Chrysafis, and Noor-E-Alam, Md.
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Mathematics - Optimization and Control - Abstract
In this paper, we define a new, special second order cone as a type-$k$ second order cone. We focus on the case of $k=2$, which can be viewed as SOCO with an additional {\em complicating variable}. For this new problem, we develop the necessary prerequisites, based on previous work for traditional SOCO. We then develop a primal-dual interior point algorithm for solving a type-2 second order conic optimization (SOCO) problem, based on a family of kernel functions suitable for this type-2 SOCO. We finally derive the following iteration bound for our framework: \[\frac{L^\gamma}{\theta \kappa \gamma} \left[2N \psi\left( \frac{\varrho \left(\tau /4N\right)}{\sqrt{1-\theta}}\right)\right]^\gamma\log \frac{3N}{\epsilon}.\]
- Published
- 2018
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36. Generalized Affine Scaling Algorithms for Linear Programming Problems
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Morshed, Md Sarowar and Noor-E-Alam, Md.
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Mathematics - Optimization and Control ,90C05, 90C51, 65 K05, 65B05, 34A25 - Abstract
Interior Point Methods are widely used to solve Linear Programming problems. In this work, we present two primal affine scaling algorithms to achieve faster convergence in solving Linear Programming problems. In the first algorithm, we integrate Nesterov's restarting strategy in the primal affine scaling method with an extra parameter, which in turn generalizes the original primal affine scaling method. We provide the proof of convergence for the proposed generalized algorithm considering long step size. We also provide the proof of convergence for the primal and dual sequence without the degeneracy assumption. This convergence result generalizes the original convergence result for the affine scaling methods and it gives us hints about the existence of a new family of methods. Then, we introduce a second algorithm to accelerate the convergence rate of the generalized algorithm by integrating a non-linear series transformation technique. Our numerical results show that the proposed algorithms outperform the original primal affine scaling method.
- Published
- 2018
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37. Self-help groups and opioid use disorder treatment: An investigation using a machine learning-assisted robust causal inference framework.
- Author
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Sahil Shikalgar, Scott G. Weiner, Gary J. Young, and Md. Noor-E.-Alam
- Published
- 2024
- Full Text
- View/download PDF
38. An online dynamic dual bin packing with lookahead approach for server-to-cell assignment in computer server industry.
- Author
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Mahmud Parvez, Pratik J. Parikh, Faisal Aqlan, and Md. Noor-E.-Alam
- Published
- 2024
- Full Text
- View/download PDF
39. Computational approaches for solving two-echelon vehicle and UAV routing problems for post-disaster humanitarian operations.
- Author
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Tasnim Ibn Faiz, Chrysafis Vogiatzis, and Md. Noor-E.-Alam
- Published
- 2024
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- View/download PDF
40. An explainable machine learning framework for predicting the risk of buprenorphine treatment discontinuation for opioid use disorder among commercially insured individuals.
- Author
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Jabed Al Faysal, Md. Noor-E.-Alam, Gary J. Young, Wei-Hsuan Lo-Ciganic, Amie J. Goodin, James L. Huang, Debbie L. Wilson, Tae Woo Park, and Md Mahmudul Hasan
- Published
- 2024
- Full Text
- View/download PDF
41. Sampling Kaczmarz-Motzkin method for linear feasibility problems: generalization and acceleration
- Author
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Morshed, Md Sarowar, Islam, Md Saiful, and Noor-E-Alam, Md.
- Published
- 2022
- Full Text
- View/download PDF
42. Patient outcomes following buprenorphine treatment for opioid use disorder: A retrospective analysis of the influence of patient‐ and prescriber‐level characteristics in Massachusetts, USA.
- Author
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Young, Gary J., Zhu, Tianjie, Hasan, Md Mahmudul, Alinezhad, Farbod, Young, Leonard D., and Noor‐E‐Alam, Md.
- Subjects
SUBSTANCE abuse ,DRUG overdose ,INSURANCE ,RESEARCH funding ,SCIENTIFIC observation ,TERMINATION of treatment ,TREATMENT effectiveness ,RETROSPECTIVE studies ,OPIOID abuse ,DESCRIPTIVE statistics ,LONGITUDINAL method ,DRUG prescribing ,CONFIDENCE intervals ,BUPRENORPHINE ,EVALUATION - Abstract
Background and Aims: Opioid use disorder (OUD) is treatable with buprenorphine/naloxone (buprenorphine), but many patients discontinue treatment prematurely. The aim of this study was to assess the influence of patient‐ and prescriber‐level characteristics relative to several patient outcomes following the initiation of buprenorphine treatment for OUD. Design: This was a retrospective observational investigation. We used the Public Health Data Warehouse from the Massachusetts Department of Public Health to construct a sample of patients who initiated buprenorphine treatment between 2015 and 2019. We attributed each patient to a prescriber based on information from prescription claims. We used multilevel models to assess the influence of patient‐ and prescriber‐level characteristics on each outcome. Setting: Massachusetts, USA. Participants: The study cohort comprised 37 955 unique patients and 2146 prescribers. Among patients, 64.6% were male, 52.6% were under the age of 35 and 82.2% were White, non‐Hispanic. For insurance coverage, 72.1% had Medicaid. Measurements The outcome measures were poor medication continuity, treatment discontinuation and opioid overdose, all assessed within a 12‐month follow‐up period that began with a focal prescription for buprenorphine. Each patient had a single follow‐up period. Poor medication continuity was defined as medication gaps totaling more than 7 days during the initial 180 days of buprenorphine treatment and treatment discontinuation was defined as having a medication gap for 2 consecutive months within the 12‐month follow‐up period. Findings The patient‐level rates for poor medication continuity, treatment discontinuation and opioid overdose were 59.7% [95% confidence interval (CI) = 59.2–60.2], 57.4% (95% CI = 56.9–57.9) and 10.3% (95% CI = 10.0–10.6), respectively, with 1.1% (95% CI = 1.0–1.2) experiencing a fatal opioid overdose. At the patient level, after adjustment for covariates, adverse outcomes were associated with race/ethnicity as both Black, non‐Hispanic and Hispanic patients had worse outcomes than did White, non‐Hispanic patients (Black, non‐Hispanic ‐‐ poor continuity: 1.50, 95% CI = 1.34–1.68; discontinuation: 1.44, 95% CI = 1.30–1.60; Hispanic ‐‐ poor continuity: 1.21, 95% CI = 1.12–1.31; discontinuation: 1.38, 95% CI = 1.28–1.48). Patients with insurance coverage through Medicaid also had worse outcomes than those with commercial insurance (poor continuity: 1.18, 95% CI = 1.11–1.26; discontinuation: 1.09, 95% CI = 1.03–1.16; overdose: 1.98, 95% CI = 1.75–2.23). Pre‐treatment mental health conditions and other types of chronic illness were also associated with worse outcomes (History of mental health conditions ‐‐ poor continuity: 1.11, 95% CI = 1.06–1.17; discontinuation: 1.05, CI = 1.01–1.10; overdose: 1.47, 95% CI = 1.36–1.60; Chronic health conditions ‐‐ poor continuity: 1.15, 95% CI = 1.05–1.27; discontinuation: 1.15, 95% CI = 1.05–1.26; overdose: 1.83, 95% CI = 1.60–2.10; History of substance use disorder other than for opioids ‐‐ poor continuity: 1.54, 95% CI = 1.46–1.62; discontinuation: 1.54, 95% CI = 1.47–1.62; overdose: 1.93, 95% CI = 1.80–2.07). At the prescriber level, after adjustments for covariates, adverse outcomes were associated with clinical training, as primary care physicians had higher rates of adverse outcomes than psychiatrists (poor continuity: 1.12, 95% CI = 1.02–1.23; discontinuation: 1.04, 95% CI = 1.01–1.09). A larger prescriber panel size, based on number of patients being prescribed buprenorphine, was also associated with higher rates of adverse outcomes (poor continuity: 1.36, 95% CI = 1.27–1.46; discontinuation: 1.21, 95% CI = 1.14–1.28; overdose: 1.10, 95% CI = 1.01–1.19). Between 9% and 15% of the variation among patients for the outcomes was accounted for at the prescriber level. Conclusions: Patient‐ and prescriber‐level characteristics appear to be associated with patient outcomes following buprenorphine treatment for opioid use disorder. In particular, patients' race/ethnicity and insurance coverage appear to be associated with substantial disparities in outcomes, and prescriber characteristics appear to be most closely associated with medication continuity during early treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2025
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- View/download PDF
43. Investigation on battery-less voltage of piezoelectric V-shape cantilever beam energy harvester using FEA method for pacemaker.
- Author
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Dewanjee, Joy, Islam, Md Shabiul, Yong, Wong Hin, Ullah, Najeeb, Siddiquee, Kazy Noor-E-Alam, and Islam, Mohammad Tariqul
- Subjects
FINITE element method ,HUMAN mechanics ,HIGH voltages ,ELECTRONIC circuits ,HUMAN body - Abstract
This paper presents an investigation on a battery-less voltage of Piezoelectric (PZT) V-shape cantilever beam Energy Harvester (EH) using human body vibration. The frequency ranges are walking (0–5 Hz), running (6–10 Hz) and motions (11–15 Hz) for human movement. Pacemaker devices typically require a lower resonant frequency with higher voltage which is powered by batteries. The battery has a limited duration during its working process and the battery is difficult to replace in the human body. To address the aforementioned issue, a V-shape cantilever beam EH has been developed as a solution to overcome these limitations. The cantilever beam was designed in COMSOL Multiphysics software 5.5 version using the Finite Element Analysis (FEA) method for experimental investigations followed by three categories of frequency ranges of the human body. The simulation results showed that the generated battery-less higher voltage was 269 mV (AC) at the resonant frequency of 14.37 Hz in the motion range of 11–15 Hz. Later, an Ultra Low Power (ULP) electronic circuits will be designed and simulated in the LTSPICE software to convert and boost-up from 269 mV (AC) to DC voltage attained. The estimated output power of the energy harvester system can be powered up (4.7 µW) for modern pacemaker applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
44. Typology of rice-based cropping systems for improved soil carbon management: Capturing smallholder farming opportunities and constraints in Dinajpur, Bangladesh
- Author
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Siddique, Md. Noor E. Alam, Lobry de Bruyn, Lisa A., Osanai, Yui, and Guppy, Chris N.
- Published
- 2022
- Full Text
- View/download PDF
45. Sampling Kaczmarz-Motzkin method for linear feasibility problems: generalization and acceleration.
- Author
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Md Sarowar Morshed, Md. Saiful Islam 0009, and Md. Noor-E-Alam
- Published
- 2022
- Full Text
- View/download PDF
46. A Computational Framework for Solving Nonlinear Binary Optimization Problems in Robust Causal Inference.
- Author
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Md. Saiful Islam 0009, Md Sarowar Morshed, and Md. Noor-E.-Alam
- Published
- 2022
- Full Text
- View/download PDF
47. Measurements and Correlation of Timolol Maleate Solubility in Biobased Neat and Binary Solvent Mixtures
- Author
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Zimmermann, Lennart, primary, Lee, Hung Lin, additional, Koishybay, Aibolat, additional, Vlaar, Cornelis P., additional, Monbaliu, Jean-Christophe M., additional, Romañach, Rodolfo J., additional, Noor-E-Alam, Md., additional, Myerson, Allan S., additional, and Stelzer, Torsten, additional
- Published
- 2024
- Full Text
- View/download PDF
48. A machine learning based two-stage clinical decision support system for predicting patients’ discontinuation from opioid use disorder treatment: retrospective observational study
- Author
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Md Mahmudul Hasan, Gary J. Young, Jiesheng Shi, Prathamesh Mohite, Leonard D. Young, Scott G. Weiner, and Md. Noor-E-Alam
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Buprenorphine is a widely used treatment option for patients with opioid use disorder (OUD). Premature discontinuation from this treatment has many negative health and societal consequences. Objective To develop and evaluate a machine learning based two-stage clinical decision-making framework for predicting which patients will discontinue OUD treatment within less than a year. The proposed framework performs such prediction in two stages: (i) at the time of initiating the treatment, and (ii) after two/three months following treatment initiation. Methods For this retrospective observational analysis, we utilized Massachusetts All Payer Claims Data (MA APCD) from the year 2013 to 2015. Study sample included 5190 patients who were commercially insured, initiated buprenorphine treatment between January and December 2014, and did not have any buprenorphine prescription at least one year prior to the date of treatment initiation in 2014. Treatment discontinuation was defined as at least two consecutive months without a prescription for buprenorphine. Six machine learning models (i.e., logistic regression, decision tree, random forest, extreme-gradient boosting, support vector machine, and artificial neural network) were tested using a five-fold cross validation on the input data. The first-stage models used patients’ demographic information. The second-stage models included information on medication adherence during the early phase of treatment based on the proportion of days covered (PDC) measure. Results A substantial percentage of patients (48.7%) who started on buprenorphine discontinued the treatment within one year. The area under receiving operating characteristic curve (C-statistic) for the first stage models varied within a range of 0.55 to 0.59. The inclusion of knowledge regarding patients’ adherence at the early treatment phase in terms of two-months and three-months PDC resulted in a statistically significant increase in the models’ discriminative power (p-value
- Published
- 2021
- Full Text
- View/download PDF
49. A machine learning framework to predict the risk of opioid use disorder
- Author
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Hasan, Md Mahmudul, Young, Gary J., Patel, Mehul Rakeshkumar, Modestino, Alicia Sasser, Sanchez, Leon D., and Noor-E-Alam, Md.
- Published
- 2021
- Full Text
- View/download PDF
50. Association of household fuel with acute respiratory infection (ARI) under-five years children in Bangladesh
- Author
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Md. Aminul Islam, Mohammad Nayeem Hasan, Tanvir Ahammed, Aniqua Anjum, Ananya Majumder, M. Noor-E-Alam Siddiqui, Sanjoy Kumar Mukharjee, Khandokar Fahmida Sultana, Sabrin Sultana, Md. Jakariya, Prosun Bhattacharya, Samuel Asumadu Sarkodie, Kuldeep Dhama, Jubayer Mumin, and Firoz Ahmed
- Subjects
developing countries ,solid fuels ,clean fuels ,under-five children ,acute respiratory infection (ARI) ,Public aspects of medicine ,RA1-1270 - Abstract
In developing countries, acute respiratory infections (ARIs) cause a significant number of deaths among children. According to Bangladesh Demographic and Health Survey (BDHS), about 25% of the deaths in children under-five years are caused by ARI in Bangladesh every year. Low-income families frequently rely on wood, coal, and animal excrement for cooking. However, it is unclear whether using alternative fuels offers a health benefit over solid fuels. To clear this doubt, we conducted a study to investigate the effects of fuel usage on ARI in children. In this study, we used the latest BDHS 2017–18 survey data collected by the Government of Bangladesh (GoB) and estimated the effects of fuel use on ARI by constructing multivariable logistic regression models. From the analysis, we found that the crude (the only type of fuel in the model) odds ratio (OR) for ARI is 1.69 [95% confidence interval (CI): 1.06–2.71]. This suggests that children in families using contaminated fuels are 69.3% more likely to experience an ARI episode than children in households using clean fuels. After adjusting for cooking fuel, type of roof material, child's age (months), and sex of the child–the effect of solid fuels is similar to the adjusted odds ratio (AOR) for ARI (OR: 1.69, 95% CI: 1.05–2.72). This implies that an ARI occurrence is 69.2% more likely when compared to the effect of clean fuel. This study found a statistically significant association between solid fuel consumption and the occurrence of ARI in children in households. The correlation between indoor air pollution and clinical parameters of ARI requires further investigation. Our findings will also help other researchers and policymakers to take comprehensive actions by considering fuel type as a risk factor as well as taking proper steps to solve this issue.
- Published
- 2022
- Full Text
- View/download PDF
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