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1. Assessing the efficacy of a brief universal family skills programme on child behaviour and family functioning in Gilgit-Baltistan, Pakistan: protocol for a feasibility randomised controlled trial of the Strong Families programme

Author

Marie-Claire Van Hout, Nusrat Husain, Nasim Chaudhry, Imran Bashir Chaudhry, Wadih Maalouf, Aala El-Khani, Muqaddas Asif, Salman Shahzad, Majid Sain Bux, Noor ul Zaman Rafiq, Ameer B Khoso, Zainab Zadeh, Azam Tahir, and Rakhshi Memon

Subjects
Medicine
Abstract

Purpose The global burden of mental health difficulties among children underscores the importance of early prevention. This study aims to assess the efficacy, feasibility and acceptability of the Strong Families programme in enhancing child behaviour and family functioning in low-resource settings in Gilgit-Baltistan, Pakistan.Methods and analysis This is a two-arm, multisite feasibility randomised controlled trial with an embedded process evaluation in three districts of Gilgit-Baltistan, namely Gilgit, Hunza and Skardu. 90 families living in these challenged settings, comprising a female primary caregiver aged 18 or above, and at least one child aged 8–15 years, will participate. Participants will be randomly assigned to either receive the Strong Families programme or to the waitlist group. Strong Families is a 7-hour family skills group intervention programme attended by children and their primary caregivers over 3 weeks. The waitlist group will be offered the intervention after their outcome assessment. Three raters will conduct blind assessments at baseline, 2 and 6 weeks postintervention. The primary outcome measures include the feasibility of Strong Families, as determined by families’ recruitment and attendance rates, and programme completeness (mean number of sessions attended, attrition rates). The secondary outcomes include assessment of child behaviour, parenting practices, parental adjustment and child resilience. Purposefully selected participants, including up to five caregivers from each site, researchers and facilitators delivering the intervention, will be interviewed. Descriptive statistics will be used to analyse primary and secondary outcomes. The process evaluation will be conducted in terms of programme context, reach, fidelity, dose delivered and received, implementation, and recruitment.Ethics and dissemination This study has been approved by the UNODC Drug Prevention and Health Branch in the Headquarters office of Vienna and the National Bioethics Committee of Pakistan. Findings will be disseminated through publication in reputable journals, newsletters and presentations at conferences.Trial registration number NCT05933850.

Published
2024
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2. A Global Survey on Changes in the Supply, Price, and Use of Illicit Drugs and Alcohol, and Related Complications During the 2020 COVID-19 Pandemic

Author

Ali Farhoudian, Seyed Ramin Radfar, Hossein Mohaddes Ardabili, Parnian Rafei, Mohsen Ebrahimi, Arash Khojasteh Zonoozi, Cornelis A. J. De Jong, Mehrnoosh Vahidi, Masud Yunesian, Christos Kouimtsidis, Shalini Arunogiri, Helena Hansen, Kathleen T. Brady, ISAM Global Survey Consortium (ISAM-GSC), Adrian Octavian Abagiu, Franck David Noel Abouna, Mohamed Hassan Ahmed, Basma Al-ansari, Feda Mahmmoud Abu Al-khair, Mandhar Humaid Almaqbali, Atul Ambekar, Sidharth Arya, Victor Olufolahan Asebikan, Murad Ali Ayasreh, Debasish Basu, Zoubir Benmebarek, Roshan Bhad, Mario Blaise, Nicolas Bonnet, Jennifer Brasch, Barbara Broers, Anja Busse, Jenna L. Butner, Moses Camilleri, Giovanna Campello, Giuseppe Carra, Ivan Celic, Fatemeh Chalabianloo, Abhishek Chaturvedi, José de Jesús Eduardo Noyola Cherpitel, Kelly J. Clark, Melissa Anne Cyders, Ernesto de Bernardis, Abbas Deilamizade, John Edward Derry, Naveen Kumar Dhagudu, Pavla Dolezalova, Geert Dom, Adrian John Dunlop, Mahmoud Mamdouh Elhabiby, Hussein Elkholy, Nsidibe Francis Essien, Ghandi Ilias Farah, Marica Ferri, Georgios D Floros, Catherine Friedman, Clara Hidalgo Fuderanan, Gilberto Gerra, Abhishek Ghosh, Maka Gogia, Ilias A. Grammatikopoulos, Paolo Grandinetti, Amira Guirguis, David Gutnisky, Paul Steven Haber, Peyman Hassani-Abharian, Zahra Hooshyari, Islam Ibrahim Mokhtar Ibrahim, Hada Fong-ha Ieong, Regina Nova Indradewi, Shelly Iskandar, Thahir Noorul Isra, Shobhit Jain, Sandi James, Seyyed Mohammad hossein Javadi, Keun Ho Joe, Darius Jokubonis, Acka Tushevska Jovanova, Rama Mohamed Kamal, Alexander Ivanov Kantchelov, Preethy Kathiresan, Gary Katzman, Paul Kawale, Audrey Margaret Kern, Felix Henrique Paim Kessler, Sung-Gon Sue Kim, Ann Marie Kimball, Zeljko Kljucevic, Kristiana Siste Kurniasanti, Roneet Lev, Hae Kook Lee, Aiste Lengvenyte, Shaul Lev-ran, Geni Seseja Mabelya, Mohamed Ali El Mahi, J. Maphisa Maphisa, Icro Maremmani, Laura Masferrer, Omid Massah, Orlagh McCambridge, Garrett Gregory McGovern, Aung Kyi Min, Amir Moghanibashi-Mansourieh, Jazman Mora-Rios, Indika Udaya Kumara Mudalige, Diptadhi Mukherjee, Pejic Munira Munira, Bronwyn Myers, Jayakrishnan Menon T. N., Venkata Lakshmi Narasimha, Nkemakolam Ndionuka, Ali-Akbar Nejatisafa, Kamran Niaz, Asad Tamizuddin Nizami, Jan H. Nuijens, Laura Orsolini, Vantheara Oum, Adegboyega Adekunle Oyemade, Irena Rojnia Palavra, Sagun Ballav Pant, Joselyn Paredes, Eric Peyron, Randall Alberto Quirós, Rouhollah Qurishi, Noor ul Zaman Rafiq, Ranjini Raghavendra Rao, Woraphat Ratta-apha, Karren-Lee Raymond, Jens Reimer, Eduardo Renaldo, Tara Rezapour, James Roy Robertson, Carlos Roncero, Fazle Roub, Elizabeth Jane Rubenstein, Claudia Ines Rupp, Elizabeth Saenz, Mohammad Salehi, Lampros Samartzis, Laura Beatriz Sarubbo, Nusa Segrec, Bigya Shah, Hongxian Shen, Tomohiro Shirasaka, Steve Shoptaw, Fransiskus Muronga Sintango, Veronica Andrea Sosa, Emilis Subata, Norberto Sztycberg, Fatemeh Taghizadeh, Joseph Brian Tay Wee Teck, Christian Tjagvad, Marta Torrens, Judith Meme Twala, Ramyadarshni Vadivel, Joseph Robert Volpicelli, Jelmer Weijs, Steven Michael Wintoniw, Apisak Wittayanookulluk, Marcin Wojnar, Sadia Yasir, Yimenu Yitayih, and Min Zhao

Subjects
COVID-19, addiction, substance use disorder, global survey, behavioral addiction, illicit drug market, Psychiatry, RC435-571
Abstract

Background and Aims: COVID-19 has infected more than 77 million people worldwide and impacted the lives of many more, with a particularly devastating impact on vulnerable populations, including people with substance use disorders (SUDs). Quarantines, travel bans, regulatory changes, social distancing, and “lockdown” measures have affected drug and alcohol supply chains and subsequently their availability, price, and use patterns, with possible downstream effects on presentations of SUDs and demand for treatment. Given the lack of multicentric epidemiologic studies, we conducted a rapid global survey within the International Society of Addiction Medicine (ISAM) network in order to understand the status of substance-use patterns during the current pandemic.Design: Cross-sectional survey.Setting: Worldwide.Participants: Starting on April 4, 2020 during a 5-week period, the survey received 185 responses from 77 countries.Measurements: To assess addiction medicine professionals' perceived changes in drug and alcohol supply, price, use pattern, and related complications during the COVID-19 pandemic.Findings: Participants reported (among who answered “decreased” or “increased”) a decrease in drug supply (69.0%) and at the same time an increase in price (95.3%) globally. With respect to changes in use patterns, an increase in alcohol (71.7%), cannabis (63.0%), prescription opioids (70.9%), and sedative/hypnotics (84.6%) use was reported, while the use of amphetamines (59.7%), cocaine (67.5%), and opiates (58.2%) was reported to decrease overall.Conclusions: The global report on changes in the availability, use patterns, and complications of alcohol and drugs during the COVID-19 pandemic should be considered in making new policies and in developing mitigating measures and guidelines during the current pandemic (and probable future ones) in order to minimize risks to people with SUD.

Published
2021
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3. Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey

Author

Seyed Ramin Radfar, Cornelis A. J. De Jong, Ali Farhoudian, Mohsen Ebrahimi, Parnian Rafei, Mehrnoosh Vahidi, Masud Yunesian, Christos Kouimtsidis, Shalini Arunogiri, Omid Massah, Abbas Deylamizadeh, Kathleen T. Brady, Anja Busse, ISAM-PPIG Global Survey Consortium, Marc N. Potenza, Hamed Ekhtiari, Alexander Mario Baldacchino, Adrian Octavian Abagiu, Franck David Noel Abouna, Mohamed Hassan Ahmed, Basma Al-ansari, Feda Mahmmoud Abu Al-khair, Mandhar Humaid Almaqbali, Atul Ambekar, Hossein Mohaddes Ardabili, Sidharth Arya, Victor Olufolahan Lasebikan, Murad Ali Ayasreh, Debasish Basu, Zoubir Benmebarek, Roshan Bhad, Mario Blaise, Nicolas Bonnet, Jennifer Brasch, Barbara Broers, Jenna L. Butner, Moses Camilleri, Giovanna Campello, Giuseppe Carra, Ivan Celic, Fatemeh Chalabianloo, Abhishek Chaturvedi, José de Jesús Eduardo Noyola Cherpitel, Kelly J. Clark, Melissa Anne Cyders, Ernesto de Bernardis, John Edward Derry, Naveen Kumar Dhagudu, Pavla Dolezalova, Geert Dom, Adrian John Dunlop, Mahmoud Mamdouh Elhabiby, Hussien Elkholy, Nsidibe Francis Essien, Ghandi Ilias Farah, Marica Ferri, Georgios D Floros, Catherine Friedman, Clara Hidalgo Fuderanan, Gilberto Gerra, Abhishek Ghosh, Maka Gogia, Ilias A. Grammatikopoulos, Paolo Grandinetti, Amira Guirguis, David Gutnisky, Paul Steven Haber, Peyman Hassani-Abharian, Zahra Hooshyari, Islam Ibrahim Mokhtar Ibrahim, Hada Fong-ha Ieong, Regina Nova Indradewi, Shelly Iskandar, Shobhit Jain, Sandi James, Seyyed Mohammad hossein Javadi, Keun Ho Joe, Darius Jokubonis, Acka Tushevska Jovanova, Rama Mohamed Kamal, Alexander Ivanov Kantchelov, Preethy Kathiresan, Gary Katzman, Paul Kawale, Audrey Margaret Kern, Felix Henrique Paim Kessler, Sung-Gon Sue Kim, Ann Marie Kimball, Zeljko Kljucevic, Kristiana Siste, Roneet Lev, Hae Kook Lee, Aiste Lengvenyte, Shaul Lev-ran, Geni Seseja Mabelya, Mohamed Ali El Mahi, J. Maphisa Maphisa, Icro Maremmani, Laura Masferrer, Orlagh McCambridge, Garrett Gregory McGovern, Aung Kyi Min, Amir Moghanibashi-Mansourieh, Jazman Mora-Rios, Indika Udaya Kumara Mudalige, Diptadhi Mukherjee, Pejic Munira Munira, Bronwyn Myers, Jayakrishnan Menon T N, Venkata Lakshmi Narasimha, Nkemakolam Ndionuka, Ali-Akbar Nejatisafa, Kamran Niaz, Asad Tamizuddin Nizami, Jan H. Nuijens, Laura Orsolini, Vantheara Oum, Adegboyega Adekunle Oyemade, Irena Rojnia Palavra, Sagun Ballav Pant, Joselyn Paredes, Eric Peyron, Randall Alberto Quirós, Rouhollah Qurishi, Noor ul Zaman Rafiq, Ranjini Raghavendra Rao, Woraphat Ratta-apha, Karren-Lee Raymond, Jens Reimer, Eduardo Renaldo, Tara Rezapour, James Roy Robertson, Carlos Roncero, Fazle Roub, Elizabeth Jane Rubenstein, Claudia Ines Rupp, Elizabeth Saenz, Mohammad Salehi, Lampros Samartzis, Laura Beatriz Sarubbo, Nusa Segrec, Bigya Shah, Hongxian Shen, Tomohiro Shirasaka, Steve Shoptaw, Fransiskus Muronga Sintango, Veronica Andrea Sosa, Emilis Subata, Norberto Sztycberg, Fatemeh Taghizadeh, Joseph Brian Tay Wee Teck, Christian Tjagvad, Marta Torrens, Judith Meme Twala, Ramyadarshni Vadivel, Joseph Robert Volpicelli, Jelmer Weijs, Steven Michael Wintoniw, Apisak Wittayanookulluk, Marcin Wojnar, Sadia Yasir, Yimenu Yitayih, Min Zhao, and Arash Khojasteh Zonoozi

Subjects
COVID-19 pandemic, substance use disorder, public health, drug policy, opioid agonist treatment, addiction services, Psychiatry, RC435-571
Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic.Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health responses in their own 77 countries in terms of SUD treatment and harm reduction services. The health responses were categorized around (1) managerial measures and systems, (2) logistics, (3) service providers, and (4) vulnerable groups.Results: Respondents from over 88% of countries reported that core medical and psychiatric care for SUDs had continued; however, only 56% of countries reported having had any business continuity plan, and 37.5% of countries reported shortages of methadone or buprenorphine supplies. Participants of 41% of countries reported partial discontinuation of harm-reduction services such as needle and syringe programs and condom distribution. Fifty-seven percent of overdose prevention interventions and 81% of outreach services were also negatively impacted.Conclusions: Participants reported that SUD treatment and harm-reduction services had been significantly impacted globally early during the COVID-19 pandemic. Based on our findings, we highlight several issues and complications resulting from the pandemic concerning people with SUDs that should be tackled more efficiently during the future waves or similar pandemics. The issues and potential strategies comprise the following: (1) helping policymakers to generate business continuity plans, (2) maintaining the use of evidence-based interventions for people with SUDs, (3) being prepared for adequate medication supplies, (4) integrating harm reduction programs with other treatment modalities, and (5) having specific considerations for vulnerable groups such as immigrants and refugees.

Published
2021
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4. Culturally adapted motivational interviewing with cognitive behavior therapy and mindfulness-based relapse prevention for substance use disorder in Pakistan (CAMAIB): protocol for a feasibility factorial randomised controlled trial

Author

Muqaddas Asif, Ameer B. Khoso, M. Ali Husain, Salman Shahzad, Marie-Claire Van Hout, Noor-ul-Zaman Rafiq, Steven Lane, Imran Bashir Chaudhry, and Nusrat Husain

Subjects
Medicine (miscellaneous)
Abstract

Background The use of psychoactive substances significantly impacts the health, social and economic aspects of families, communities and nations. There is a need to develop and test psychological interventions aimed for individuals with substance use disorder (SUD) in lower- and middle-income countries (LMICs), such as in Pakistan. The aim of this exploratory trial is to test the feasibility and acceptability of two culturally adapted psychological interventions in a factorial randomised controlled trial (RCT). Methods The proposed project will be conducted in three phases. The first phase of the study will focus on cultural adaptation of the interventions through qualitative interviews with key stakeholders. The second phase will be to refine and produce manually assisted interventions. Third and last stage would be to assess the feasibility of the culturally adapted interventions through a factorial RCT. The study will be carried out in Karachi, Hyderabad, Peshawar, Lahore and Rawalpindi, Pakistan. Recruitment of participants will take place from primary care and volunteer organisations/drug rehabilitation centres. A total of 260 individuals diagnosed with SUD (n = 65) in each of the four arms will be recruited. The intervention will be delivered weekly over a period of 12 weeks in both individual and group settings. Assessments will be carried out at baseline, at 12th week (after completion of intervention) and 24th week post-randomisation. The analysis will determine the feasibility of recruitment, randomisation, retention and intervention delivery. Acceptability of intervention will be determined in terms of adherence to intervention, i.e. the mean number of sessions attended, number of home assignments completed, attrition rates, as well as through process evaluation to understand the implementation process, context, participants’ satisfaction, and impact of the study intervention. The health resource use and impact on the quality of life will be established through health economic data. Discussion This study will provide evidence for feasibility and acceptability of culturally adapted manually assisted psychological interventions for individuals with SUD in the context of Pakistan. The study will have clinical implications if intervention is proven feasible and acceptable. Trial registration Name of the registry: ClinicalTrials.gov, Trial registration number: NCT04885569, Date of registration: 25th April 2021.

Published
2023
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5. Culturally Adapted Motivational Interviewing with Cognitive Behavior Therapy and Mindfulness Based Relapse Prevention for Substance Use Disorder in Pakistan (CAMAIB): Protocol of a feasibility factorial randomised controlled trial

Author

MUQADDAS ASIF, Ameer B Khoso, M Ali Husain, Salman Shahzad, Marie-Claire Van Hout, Noor-ul-Zaman Rafiq, Steven Lane, Imran Bashir Chaudhry, and Nusrat Husain

Abstract

Background The use of psychoactive substances significantly impacts the health, social and economic aspects of families, communities and nations. There is a need to develop and test psychological interventions aimed for people with Substance Use Disorder (SUD) in Lower and Middle Income Countries (LMICS), such as in Pakistan. The aim of this exploratory trial is to test the feasibility and acceptability of two culturally adapted psychological interventions in a factorial Randomized Controlled Trial (RCT). Methods The proposed project will be conducted in three phases. The first phase of the study will focus on cultural adaptation of the interventions through qualitative interviews with key stakeholders. The second phase will be to refine the intervention and to produce manual assisted intervention. Third and last stage would be to assess the feasibility of the culturally adapted interventions through a factorial RCT. The study will be carried out in Karachi, Hyderabad, Peshawar, Lahore and Rawalpindi, Pakistan. Recruitment of participants will take place from primary care and volunteer organisations/drug rehabilitation centres. A total of 260 individuals diagnosed with SUD (n=65) in each of the four arms will be recruited. The intervention will be delivered weekly over a period of 12 weeks in both individual and group setting. Assessments will be carried out at baseline, at 12th week (after completion of intervention) and 24th week post-randomisation. The analysis will determine feasibility of recruitment, randomisation, retention and intervention delivery. Acceptability of intervention will be determined in terms of adherence to intervention i.e. the mean number of sessions attended, number of home assignments completed, attrition rates as well as through process evaluation to understand the implementation process, context, participants’ satisfaction, and impact of study intervention. The health resource use and impact on the quality of life will be established through health economic data. Discussion This study will provide evidence for feasibility and acceptability of culturally adapted manually assisted psychological interventions for people with SUD in the context of Pakistan. The study will have clinical implications if intervention is proven feasible and acceptable. Trial registration Name of the registry: ClinicalTrials.gov Trial registration number: NCT04885569 Date of registration: 25th April 2021, retrospectively registered URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT04885569

Published
2022
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