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Background: Stress in medical students is a global concern. Stress disturbs the sympathovagal balance and affects heart rate variability, a sign of healthy cardiovascular homeostasis. Various strategies have been used globally to combat stress and its effects. Aim: To determine how blowing balloon exercise modulatesheart rate variability (HRV) in stressed medical students. Methodology: A pretest-posttest quasi-experimental study wasconducted among stressed medical students at Islamic international medical college Rawalpindi Pakistan. Sixty students diagnosed with moderate stress were enrolled based on Depression Anxiety Stress Scale (DASS) Proforma. The study population was selected by simple random sampling via the balloting method among the stressed medical students. Study participants underwent a supervised blowing balloon exercise.Before and after a supervised blowing balloon exercise, the participants' pulmonary function tests, electrocardiograms, and DASS scores were measured. Participants' ECGs and pulmonary function tests were recorded viaPower lab (A.D. Instruments, model yam 4/25T, South Wales, Australia). Results: Blowing balloon exercise resulted in a significant reduction of DASS score (p

Objectives: Type 2 diabetes is characterized by hyperglycemia and occurs as a result of insulin resistance and pancreatic beta cells failure to compensate. Present study was conducted to determine the antidiabetic effect of Withania coagulans and liraglutide on postprandial serum insulin levels and pancreatic histological features in streptozotocin induced diabetic rat. Study Design: This Randomized Control Trial. Setting: At multidisciplinary lab Islamic International Medical College, Rawalpindi in collaboration with Animal House, National Institute of Health, Islamabad. Period: From March 2016 to April 2017. Material and Methods: Forty male Sprague daily rats were randomly divided into normal Control Group A (n=10) and Experimental Group (n=30). Experimental group was given streptozotocin (30mg/kg/day) intraperitoneally for 5 days and diabetes was confirmed in experimental group by measuring fasting blood glucose level (mg/dl). Experimental group was divided further into Group B (Diabetic control), Group C (Withania coagulans treated) and Group D (Liraglutide treated). Group C were given Withania coagulans in addition to normal diet and Group D received Liraglutide besides normal diet for 30 days. Second sampling for evaluating postprandial serum insulin level and pancreatic histology was done after 30 days. Result: Postprandial serum insulin levels of Withania coagulans treated Group C (5.54 + 0.23 μU/ml) and Liraglutide treated Group D (6.06 + 0.17 μU/ml) were significantly raised in comparison with Diabetic control Group B (3.50 + 0.19 μU/ml), whereas islets of Langerhans cell morphology were markedly improved in Group C and D as compared to Group B. Conclusion: Withania coagulans significantly increases postprandial serum insulin level and improves pancreatic beta cells architecture.

Objective: To evaluate effect of Withania coagulans and liraglutide on serum Glucagon like peptide-1, Postprandial and Fasting Blood Glucose levels in streptozotocin induced diabetic rat. Study Design and Setting: This randomize control trile was conducted at Islamic International Medical College in collaboration with National Institute of Health Islamabad. Methodology: This randomized controlled study was performed on a total of forty male Sprague dawly rats, which were initially divided into two groups; Group A (n=10) and Experimental Group (n=30). Diabetes in the Experimental group B was induced by intraperitoneal administration of streptozotocin for 5 days (30mg/kg/day). Diabetes was checked in experimental group by measuring fasting blood glucose (mg/dl) on day 6. Experimental group was further divided into Group B (Diabetic control), Group C (Withania coagulans-treated) and Group D (Liraglutide-treated). Blood sampling was done at day 30 and serum GLP-1, postprandial and fasting blood glucose levels were measured and compared in all groups. Results: Fasting and postprandial blood glucose levels of group C and D were significantly reduced as compared to group B. Serum GLP-1 levels were significantly increased in group C and D as compared to group B. Conclusion: Withania coagulans reduces hyperglycemia in diabetic rats through increasing GLP-1 hormone.

Background: The factors associated with infection in oral candida are countless. This infection is mainly caused by bad prosthetic cleanliness. Objective: The goal of current research study was to assess that how oral candida growth is influenced by wearing false teeth all over night and gender. Patients and Methods: The present research was organized at Sir Ganga Ram Hospital, Lahore (October 2017 to August 2019). Total patients enrolled for this research were forty. The males and females were in equal number i.e. 20. These patients were between fifty to sixty-five years of age and complete denture wearer for first time. Those patients were not selected for the study who were found with smoking habit, diabetes and with the record of treatment with radiotherapy and chemotherapy in the previous six months. For the assemblage of sample, the method used was oral rinse on some time in a day. In this method, each patient was given ten milliliter of sterile saline in a sterile container that was disposable. They were asked to rinse for the time period of sixty seconds. Quantitative and qualitative growth of candida was examined and Gram stain, microscopy and colony count were measured after sending the sample to Microbiology section of pathology department of the hospital. Results: It is concluded by the results that candida growth is increased by overnight denture wearing. It was also observed that after one month of wearing complete denture, the dissimilarity in candida growth in females was valuable. Conclusion: It is concluded that dentures should be removed during night, as in case of eyeglasses. In this way, denture stomatitis will be avoided. Moreover, information should be provided about oral cleanliness to common people, especially to females. Keywords: Denture, Candida and Sterile Container.