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17 results on '"Nonaka, Kiichi"'

8. Cortical Bone Mineral Density and Osteonal Activity in Mid-diaphysis of Long Bones in Female Beagle Dogs

Author

Fukuda, Satoshi, Iida, Haruzo, and Nonaka, Kiichi

Subjects
musculoskeletal diseases, musculoskeletal system
Abstract

Bone mineral density (BMD) is widely used as a parameter to estimate bone fracture risk. The BMD of long bones (tibia, femur and humerus) that the body weight burden is different, larger on the fore limbs than the hind limbs, were measured to examine whether BMD is reliable as a parameter to estimate the risk of bone fracture. The long bones labeled with tetracycline were obtained from female beagle dogs aged from 2 to 16 years. The cortical BMD and related parameters such as cortical area, thickness and strength strain index (SSI) in the mid-diaphysis of long bones were measured by pQCT. Thereafter, the undecalcified bone section was obtained to observe the bone activity by differentiating tetracycline-labeled, and eroded osteons in the anterior and posterior regions. The cortical BMD of mid-diaphysis was not different among three bones and decreased after 7-8 years. The cortical area of humerus was larger than those of tibia and femur, and the cortical thickness of humerus as well as tibia was wider than that of femur, and both values decreased after 7-8 years. The SSI of humerus was higher than femur and tibia after 7-8 years. In the mid-diaphysis of tibia, the tetracycline-labeled osteons were observed in the anterior region more than in the posterior region and decreased with age. The osteons with erosion was frequently in the posterior regions with increasing age. The results indicate that the bone strength (SSI) depends on the shapes such as cortical area and thickness rather than the BMD and the alteration of osteonal activity and morphology., 1st Joint Meeting of the International Bone and Mineral Society and the Japanese Society for Bone and Mineral Research

Published
2003

9. A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats

Author

Miyagawa, Kazuaki, primary, Kozai, Yusuke, additional, Ito, Yumi, additional, Furuhama, Takami, additional, Naruse, Kouji, additional, Nonaka, Kiichi, additional, Nagai, Yumiko, additional, Yamato, Hideyuki, additional, Kashima, Isamu, additional, Ohya, Keiichi, additional, Aoki, Kazuhiro, additional, and Mikuni-Takagaki, Yuko, additional

Published
2010
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10. Suppressed Bone Turnover by Long-Term Bisphosphonate Treatment Accumulates Microdamage but Maintains Intrinsic Material Properties in Cortical Bone of Dog Rib

Author

Komatsubara, Satoshi, primary, Mori, Satoshi, additional, Mashiba, Tasuku, additional, Li, Jilliang, additional, Nonaka, Kiichi, additional, Kaji, Yoshio, additional, Akiyama, Tomoyuki, additional, Miyamoto, Kensaku, additional, Cao, Yongping, additional, Kawanishi, Jun, additional, and Norimatsu, Hiromichi, additional

Published
2005
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11. Human parathyroid hormone (1–34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora

Author

Komatsubara, Satoshi, primary, Mori, Satoshi, additional, Mashiba, Tasuku, additional, Nonaka, Kiichi, additional, Seki, Azusa, additional, Akiyama, Tomoyuki, additional, Miyamoto, Kensaku, additional, Cao, Yongping, additional, Manabe, Takeshi, additional, and Norimatsu, Hiromichi, additional

Published
2005
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12. Suppressed Bone Turnover by Long-Term Bisphosphonate Treatment Accumulates Microdamage but Maintains Intrinsic Material Properties in Cortical Bone of Dog Rib

Author

Komatsubara, Satoshi, primary, Mori, Satoshi, additional, Mashiba, Tasuku, additional, Li, Jilliang, additional, Nonaka, Kiichi, additional, Kaji, Yoshio, additional, Akiyama, Tomoyuki, additional, Miyamoto, Kensaku, additional, Cao, Yongping, additional, Kawanishi, Jun, additional, and Norimatsu, Hiromichi, additional

Published
2004
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16. [Assessment of volumetric bone mineral density and geometry for hip with clinical CT device].

Author

Nonaka K and Uchiyama S

Subjects
Aged, Aged, 80 and over, Densitometry instrumentation, Diphosphonates administration & dosage, Female, Humans, Ibandronic Acid, Life Style, Middle Aged, Risk, Teriparatide administration & dosage, Bone Density, Densitometry methods, Femur metabolism, Femur pathology, Hip Fractures prevention & control, Tomography, X-Ray Computed instrumentation
Abstract

It is one of the most important challenges for preventing hip fractures to establish an accurate non-invasive assessment of hip fracture risk. Quantitative computed tomography (QCT) is able to analyze not only volumetric bone mineral density (mg/cm3) of trabecular and cortical bone compartment separately, but also geometry and biomechanical parameters in bone such as cross-sectional area, cortical bone thickness, section modulus, buckling ratio etc. The analysis of geometry and biomechanical parameters at hip could provide better prediction of hip fracture risk, better understanding pathogenesis of hip fractures, and thus better selection of drug and/or lifestyle-based interventions.

Published
2011
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17. Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis.

Author

Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, and Amagasa T

Subjects
Animals, Arthritis, Experimental chemically induced, Arthritis, Rheumatoid chemically induced, Cattle, Collagen Type II, Inflammation prevention & control, Male, Mice, Mice, Inbred DBA, Protein Binding drug effects, Receptors, Tumor Necrosis Factor metabolism, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Arthritis, Experimental drug therapy, Arthritis, Rheumatoid drug therapy, Bone Resorption prevention & control, Peptides, Cyclic therapeutic use, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract

The cyclic peptide WP9QY (YCWSQYLCY), which was designed to mimic the most critical tumor necrosis factor (TNF) alpha recognition loop on type1 TNF receptor, antagonizes the effects of TNFalpha. In this study, we investigated the effects of WP9QY peptide on collagen-induced arthritis (CIA) mice to evaluate its effects on inflammatory bone destruction. DBA/1J mice were injected intradermally at the base of the tail with bovine type II collagen, emulsified in complete Freund's adjuvant on day 0 and 21. The three sets of WP9QY peptide injections (24 mg/kg x 8 times per day) were performed before the onset of paw swelling. Mice were sacrificed at day 38 and thereafter, the arthritis scores as well as radiographical and histological outcomes were assessed. WP9QY peptide inhibited CIA-induced increase in the arthritis score. Furthermore, histomorphometric analysis of the tibial epiphysis region revealed that WP9QY peptide inhibited the increase of synovial pannus infiltration and the decrease of bone volume, which were induced by the CIA. The WP9QY treatment prevented the inflammation as well as bone destruction of the joints in the CIA mice, suggesting that the administration of WP9QY peptide might be useful for developing a drug to prevent inflammatory bone destruction.

Published
2005

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