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Housing quality is a determinant of health, wellbeing and inequities. Since 2013, changes to Permitted Development Rights (PDR) allow conversions of non-residential buildings into housing without planning permission in England. We explored the potential health and wellbeing impacts of such ‘PDR housing’ through an online survey and semi-structured interviews in four London boroughs. We found an association between low wellbeing and lack of residential space and accommodation cooling options, fewer local amenities and lower perceived safety. Participants highlighted problems with windows and outdoor space. Poor quality PDR conversions may pose health and wellbeing risks that could be avoided through regulation and enforcement.