Search

Your search keyword '"Nomura, Fumikazu"' showing total 111 results
Start Over Author "Nomura, Fumikazu"
111 results on '"Nomura, Fumikazu"'

8. Additive effects of l-arginine infusion and leukocyte depletion on recovery after hypothermic ischemia in neonatal lamb hearts

Author

Hiramatsu, Takeshi, Forbess, Joseph M., Miura, Takuya, Nomura, Fumikazu, and Mayer, John E.

Subjects
Infants (Newborn), Ischemia, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0022-5223(05)80023-6 Byline: Takeshi Hiramatsu (a)(b), Joseph M. Forbess (a)(b), Takuya Miura (a)(b), Fumikazu Nomura (a)(b), John E. Mayer (a)(b) Abstract: Prior experiments on hypothermic ischemia/reperfusion have shown that (1) leukocytes have an important role in the injury resulting from hypothermic ischemia/reperfusion and (2) endothelial dysfunction with reduced release of nitric oxide occurs after hypothermic ischemia/reperfusion. l-Arginine is a nitric oxide precursor, and the effects of nitric oxide released from endothelial cells include vasorelaxation and inhibition of leukocyte adhesion to endothelium. The potential roles of an interaction between endothelial dysfunction and leukocyte-mediated injury were examined in neonatal hearts. Thirty-two isolated, blood-perfused neonatal lamb hearts were subjected to 2 hours of 10[degrees]C cardioplegic ischemia. Group l-arginine received a 3 mmol/L dose of l-arginine during the first 20 minutes of reperfusion. In group leukocyte depletion, leukocytes were depleted (Sepacell filter) from the perfusate before reperfusion. In group l-arginine+leukocyte depletion, leukocytes were depleted and a 3 mmol/L dose of l-arginine was infused during early reperfusion. The control group had no intervention during reperfusion. At 30 minutes of reperfusion, left ventricular maximum developed pressure, positive maximum and negative maximum first derivative of left ventricular pressure (dP/dt), developed pressure at V10 (volume that produces a left ventricular enddiastolic pressure of 10 mm Hg at baseline measurement), and dP/dt at V10 were measured. Coronary blood flow was continuously monitored and oxygen consumption was also measured to evaluate the metabolic recovery. In each heart, we also tested coronary vascular resistance response to the endothelium-dependent vasodilator acetylcholine 10.sup.-7 mol/L and the endothelium-independent vasodilator trinitroglycerin 3x10.sup.-5 mol/L to assess endothelial function. Results are given as mean percent recovery of baseline values [+ or -] standard deviation. Group l-arginine+leukocyte depletion showed significantly greater recovery of left ventricular function than the other three groups, and groups l-arginine and leukocyte depletion also showed better recovery than the control group (positive maximum dP/dt: control group = 68.3% [+ or -] 8.8%, group l-arginine = 88.8% [+ or -] 3.8%, group l-arginine+leukocyte depletion = 100.6% [+ or -] 8.7%, group leukocyte depletion = 79.3% [+ or -] 8.1%; p Author Affiliation: (a) Department of Cardiac Surgery, Children's Hospital Boston, Mass. USA (b) Harvard Medical School, Boston, Mass. USA Article History: Received 12 October 1994; Accepted 21 November 1994

Published
1995

14. Cost Performance and Efficacy of Off-pump Coronary Artery Bypass Grafting

Author

Nomura, Fumikazu, Mukai, Shogo, Tamura, Kentaro, Shimazutsu, Kazufumi, Okuma, Kazuhide, Ihara, Katsuhiko, and 国立情報学研究所

Subjects
surgical procedures, operative, Off-Pump CABG, Cost performance, cardiovascular diseases
Abstract

Off-pump coronary artery bypass grafting (Off-Pump CABG) may provide an alternative form of surgical revascularization by avoiding the unwanted complications of cardiopulmonary bypass, particularly in high-risk patients. To clarify the efficacy and cost performance of Off- Pump CABG, we studied the postoperative course of Off-Pump CABG and compared it to On- pump coronary artery bypass grafting (On-Pump CABG). From Aug. 1998 to Feb. 2002, twenty-eight patients who had preoperative complications such as cerebral vascular disease (11), chronic renal failure (4), atheromatous aorta (4), one lung (1), severely impaired left ventricular function (6), re-do CABG (1), and cancer (1) underwent Off- Pump CABG. Another thirty-six patients who underwent On-Pump CABG served as a control. The Off-Pump CABG patients were almost the same age as the On-Pump CABG patients (68 ± 8 vs 64 ± 8 years, ns). The Number of grafts was similar in both groups (2.6 ± 1.0 vs 2.9 ± 1.0, ns). Peak CK, peak CKMB, peak LDH, and peak GOT release were significantly lower in the Off-Pump CABG group compared with the On-Pump CABG group. Graft patency rates were similar in both groups (98 0n Off-Pump CABG vs 98 0n On-Pump CABG). The total cost for surgery and patient care was significantly lower (p

Published
2002

24. Rationale for the Use of Combination Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Therapy in Heart Failure

Author

Yasumura, Yoshio, primary, Miyatake, Kunio, additional, Okamoto, Hiroshi, additional, Miyauchi, Takeshi, additional, Kawana, Masatoshi, additional, Tsutamoto, Takayoshi, additional, Kitakaze, Masafumi, additional, Matsubara, Hiroaki, additional, Takaoka, Hideyuki, additional, Anzai, Teisuke, additional, Himeno, Hideo, additional, Yokoyama, Hiroyuki, additional, Yokoya, Koichi, additional, Shintani, Uichirou, additional, Hashimoto, Katsuji, additional, Koretsune, Yukihiro, additional, Nakamura, Yukio, additional, Imai, Katsuji, additional, Maruyama, Shingo, additional, Masaoka, Yoshiko, additional, Sekiya, Michihito, additional, Shiraki, Teruo, additional, Shinohara, Hisanori, additional, Ozono, Keizaburo, additional, Matsuoka, Tatsuru, additional, Miyao, Yuji, additional, and Nomura, Fumikazu, additional

Published
2004
Full Text
View/download PDF

49. Evaluation of right ventricular function using gated equilibrium blood pool radionuclide ventriculography in patients with congenital volume and pressure overload late after surgical repair.

Author

HIRATA, NOBUAKI, primary, SAKAKIBARA, TETSUO, additional, WATANABE, SHINICHIRO, additional, NOMURA, FUMIKAZU, additional, AKAMATSU, HIROKI, additional, MATSUMURA, YASUSHI, additional, YAMAMOTO, KAZUHIRO, additional, SASAKI, JIRO, additional, and KODAMA, KAZUHISA, additional

Published
1991
Full Text
View/download PDF

50. Relationship between coagulation cascade, cytokine, adhesion molecule and aortic aneurysm

Author

Nomura, Fumikazu, Ihara, Akihiro, Yoshitatsu, Masao, Tamura, Kentaro, Katayama, Akira, and Ihara, Katsuhiko

Subjects
*AORTIC aneurysms, *ATHEROSCLEROSIS
Abstract

Objectives: Patients with aortic aneurysm (AA) were in the chronic inflammatory condition and are often combined with disseminated intervascular coagulation. Recent studies demonstrated that atherosclerosis was inflammatory disease. AA and severe atherosclerosis with ulcer formation contain macrophages and T lymphocytes and accelerate the production of interleukin (IL)-2, which activates lymphocytes and lead to further adhesion of leukocytes. This study was designed to clarify the coagulation condition, cytokine, adhesion molecule, and collagen turnover in patients with AA and finally their relationship with the aneurysmal size. Methods: Thrombin–antithrombin III complex (TAT), plasma D-dimer, serum type III procollagen peptide (PIIIP), serum soluble IL-2 receptor (sIL-2R), Free tissue factor pathway inhibitor (TFPI), and soluble intercellular adhesion molecule (ICAM-1) were measured preoperatively around the same period when computed tomography (CT) was taken in 17 patients with AA (mean age: 72.2 years). Age-matched (mean age:70 years) volunteers were served as control. Maximum aneurysmal size was measured by CT and aneurysmal volume was also calculated from CT. Results: AA patients showed significantly higher level in preoperative TAT and D-dimer compared to control (TAT: control 2.5±1.2 ng/ml, pre 7.2±4.5, ng/ml; P=0.0001; D-dimer: control 107±46 U/ml, pre 420±256 U/ml; P=0.0001). Cytokine also showed higher level preoperatively (sIL-2R: control 398±132 U/ml, pre 735±260 U/ml; P=0.0001). TFPI showed higher value preoperatively (control 22.9±4.9 ng/ml, pre 30.4±6.9 ng/ml; P=0.003). PIIIP (collagen turnover) showed no difference between the groups (P=0.0057) and neither did ICAM-1(P=0.0087). TAT (r=0.799, P=0.0001), D-dimer (r=0.56, P=0.0193), sIL-2R (r=0.709, P=0.0021), PIIIP (r=0.561, P=0.00239), and sICAM-1 (r=0.505, P=0.046) level showed positive correlation with aortic aneurysmal size and also TAT D-dimer, and sIL-2R levels were positively correlated with aneurysmal volume (r=0.714 P=0.0013, r=0.556 P=0.00204, r=0.693 P=0.0029, respectively). Conclusions: AA patients were in the hypercoagulation and inflammatory condition. Aneurysmal size was well correlated with TAT, D-dimer, sIL-2R, PIIIP, and sICAM-1, suggesting that these markers could be good diagnostic and monitoring tool for the disease progression. [Copyright &y& Elsevier]

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results