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3. No major differences in perinatal and maternal outcomes between uninterrupted embryo culture in time-lapse system and conventional embryo culture.

Author

Ahlström, A, Lundin, K, Cimadomo, D, Coticchio, G, Selleskog, U, Westlander, G, Winerdal, J, Stenfelt, C, Callender, S, Nyberg, C, Åström, M, Löfdahl, K, Nolte, L, Sundler, M, Kitlinski, M, Soltic, I Liljeqvist, Bohlin, T, Baumgart, J, Lindgren, K E, and Yaldir, F Gülen

Subjects
OVUM donation, SPERM donation, LOW birth weight, EMBRYO implantation, EMBRYOS
Abstract

STUDY QUESTION Is embryo culture in a closed time-lapse system associated with any differences in perinatal and maternal outcomes in comparison to conventional culture and spontaneous conception? SUMMARY ANSWER There were no significant differences between time-lapse and conventional embryo culture in preterm birth (PTB, <37 weeks), low birth weight (LBW, >2500 g) and hypertensive disorders of pregnancy for singleton deliveries, the primary outcomes of this study. WHAT IS KNOWN ALREADY Evidence from prospective trials evaluating the safety of time-lapse incubation for clinical use show similar embryo development rates, implantation rates, and ongoing pregnancy and live birth rates when compared to conventional incubation. Few studies have investigated if uninterrupted culture can alter risks of adverse perinatal outcomes presently associated with IVF when compared to conventional culture and spontaneous conceptions. STUDY DESIGN, SIZE, DURATION This study is a Swedish population-based retrospective registry study, including 7379 singleton deliveries after fresh embryo transfer between 2013 and 2018 from selected IVF clinics. Perinatal outcomes of singletons born from time-lapse-cultured embryos were compared to singletons from embryos cultured in conventional incubators and 71 300 singletons from spontaneous conceptions. Main perinatal outcomes included PTB and LBW. Main maternal outcomes included hypertensive disorders of pregnancy (pregnancy hypertension and preeclampsia). PARTICIPANTS/MATERIALS, SETTING, METHODS From nine IVF clinics, 2683 singletons born after fresh embryo transfer in a time-lapse system were compared to 4696 singletons born after culture in a conventional incubator and 71 300 singletons born after spontaneous conception matched for year of birth, parity, and maternal age. Patient and treatment characteristics from IVF deliveries were cross-linked with the Swedish Medical Birth Register, Register of Birth Defects, National Patient Register and Statistics Sweden. Children born after sperm and oocyte donation cycles and after Preimplantation Genetic testing cycles were excluded. Odds ratio (OR) and adjusted OR were calculated, adjusting for relevant confounders. MAIN RESULTS AND THE ROLE OF CHANCE In the adjusted analyses, no significant differences were found for risk of PTB (adjusted OR 1.11, 95% CI 0.87–1.41) and LBW (adjusted OR 0.86, 95% CI 0.66–1.14) or hypertensive disorders of pregnancy; preeclampsia and hypertension (adjusted OR 0.99, 95% CI 0.67–1.45 and adjusted OR 0.98, 95% CI 0.62–1.53, respectively) between time-lapse and conventional incubation systems. A significantly increased risk of PTB (adjusted OR 1.31, 95% CI 1.08–1.60) and LBW (adjusted OR 1.36, 95% CI 1.08–1.72) was found for singletons born after time-lapse incubation compared to singletons born after spontaneous conceptions. In addition, a lower risk for pregnancy hypertension (adjusted OR 0.72 95% CI 0.53–0.99) but no significant difference for preeclampsia (adjusted OR 0.87, 95% CI 0.68–1.12) was found compared to spontaneous conceptions. Subgroup analyses showed that some risks were related to the day of embryo transfer, with more adverse outcomes after blastocyst transfer in comparison to cleavage stage transfer. LIMITATIONS, REASONS FOR CAUTION This study is retrospective in design and different clinical strategies may have been used to select specific patient groups for time-lapse versus conventional incubation. The number of patients is limited and larger datasets are required to obtain more precise estimates and adjust for possible effect of additional embryo culture variables. WIDER IMPLICATIONS OF THE FINDINGS Embryo culture in time-lapse systems is not associated with major differences in perinatal and maternal outcomes, compared to conventional embryo culture, suggesting that this technology is an acceptable alternative for embryo incubation. STUDY FUNDING/COMPETING INTEREST(S) The study was financed by a research grant from Gedeon Richter. There are no conflicts of interest for all authors to declare. TRIAL REGISTRATION NUMBER N/A [ABSTRACT FROM AUTHOR]

Published
2023
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4. Articulated Statistical Shape Model-Based 2D-3D Reconstruction of a Hip Joint

Author

Balestra, S., Schumann, S., Heverhagen, J., Nolte, L., Zheng, G., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Stoyanov, Danail, editor, Collins, D. Louis, editor, Sakuma, Ichiro, editor, Abolmaesumi, Purang, editor, and Jannin, Pierre, editor

Published
2014
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12. Monitoring and Repair of Cement-Geomaterial Interfaces in Borehole and Repository Scenarios.

Author

Matteo, Edward N, primary, McMahon, Kevin A., additional, Camphouse, Russell Chris, additional, Dewers, Thomas, additional, Jove-Colon, Carlos F., additional, Fuller, Timothy Jesse, additional, Mohahgheghi, J., additional, Stormont, J. C, additional, Taha, M. R., additional, Pyrak-Nolte, L., additional, Wang, C., additional, Douba, A., additional, Genedy, M., additional, Fernandez, S. G., additional, Kandil, U. F., additional, Soliman, E. E., additional, Starr, J., additional, and Stenko, M., additional

Published
2019
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13. Final Report

Author

Akhbari, D., primary, Akkutlu, Y, additional, Altman, S. J., additional, Aman, M, additional, Aminzadeh, B, additional, Arbogast, T., additional, Bagaria, H. G., additional, Balhoff, M, additional, Bauer, S. J., additional, Bennett, P. C., additional, Bhagmane, J., additional, Bielawski, C. W., additional, Bishop, J. E., additional, Biswal, S. L., additional, Bollinger, J. A., additional, Bowden, M. E., additional, Boyd, V., additional, Broome, S. T., additional, Bryant, S., additional, Bryndzia, T, additional, Butler, D, additional, Cardenas, B, additional, Cassidy, M, additional, Cha, M, additional, Chan, M.A., additional, Chang, C, additional, Chaudhary, k, additional, Chen, X., additional, Chen, H, additional, Chen, Y, additional, Chini, G. P., additional, Choens, C, additional, Chojnicki, Kirsten, additional, Chung, D H, additional, Cole, D. R., additional, Cornell, K. A., additional, Craddock, P, additional, Criscenti, L. J., additional, Cui, L, additional, Cygan, R T, additional, Daigle, H, additional, Daniel, S R, additional, Davison, S M, additional, Dehghanpour, H, additional, Delshad, M, additional, Deng, W, additional, Dewers, T A, additional, DiCarlo, D, additional, Dong, J, additional, Duan, Z, additional, Eichhubl, P, additional, Elhag, A S, additional, Ellison, C J, additional, Espinoza, D N, additional, Estep, D, additional, Evans, J, additional, Fanizza, M F, additional, Foster, L M, additional, Foster, E L, additional, Fouke, B W, additional, Ganis, B, additional, Geier, M, additional, Ghosh, R, additional, Gilbert, K, additional, Gomez, S, additional, Guiltinan, E J, additional, Hackley, P C, additional, Hardy, C D, additional, Hart, D B, additional, Hayman, N W, additional, He, B, additional, Heath, J E, additional, Hernandez-Uribe, L. Alberto, additional, Hess, N J, additional, Hesse, M A, additional, Hirasaki, G J, additional, Ho, T A, additional, Ho, J, additional, Hosseini, S A, additional, Hu, M, additional, Huang, C S, additional, Hueckel, T, additional, Huh, C, additional, Hung, C H, additional, Ilgen, A G, additional, Illangasekare, T. H., additional, Ingram, D R, additional, Iqbal, M, additional, Islan, A, additional, Jammoul, M, additional, Javier, K J, additional, Jensen, E W, additional, Jessen, K, additional, Jiang, H, additional, Jin, S, additional, Joekar-Niasar, V, additional, Johnston, K P, additional, Jung, J, additional, Jung, H, additional, Juntunen, M, additional, Kang, Q, additional, Katz, L, additional, Kelemen, P B, additional, Kelkar, C W, additional, Kelly, E D, additional, Ketcham, R A, additional, Kharaka, Y K, additional, Kianinejad, A, additional, Killough, J E, additional, Kim, S, additional, Kim, K, additional, Kim, M F, additional, Kirk, M F, additional, Kitnidis, P, additional, Kmetz, A A, additional, Kneafsey, T J, additional, Kobos, P, additional, Kong, X, additional, Kotsmar, C, additional, Krafczyk, M, additional, Krishnamurthy, P G, additional, Kruichak, J N, additional, Kucala, A, additional, Kumar, K, additional, Kwok, A, additional, Lake, L, additional, Larson, E S, additional, Larson, T E, additional, Lee, S, additional, Lee, Y J, additional, Lee, J, additional, Lee, W, additional, Leist, E A, additional, Leung, W, additional, Leung, J Y, additional, Leung, Y, additional, Liang, Y, additional, Lin, E L, additional, Lisabeth, H P, additional, Liu, R, additional, Liu, H, additional, Liu, Z C, additional, Lotfollahi, M, additional, Luo, L S, additional, Lützenkirchen, J, additional, Lyon, B A, additional, Ma, K, additional, Maisano, J A, additional, Major, J R, additional, Martinez, M J, additional, Matteo, E, additional, McFadden, C, additional, McGrath, L K, additional, McKenna, S A, additional, McNeece, C J, additional, Meckel, T A, additional, Mehmani, A, additional, Mehmani, Y, additional, Merino, E, additional, Metaxas, A E, additional, Mikelić, A, additional, Milner, T E, additional, Mirzaei, M, additional, Moaseri, E, additional, Mozley, P S, additional, Myshakin, E M, additional, Nakshatrala, K B, additional, Neilson, B M, additional, Newell, P, additional, Nguyen, Q P, additional, Noble, D R, additional, Noguera, J A, additional, Olson, J E, additional, Omelon, C R, additional, Oostrom, M, additional, Ortiz, M R, additional, Ovaysi, S, additional, Parks, M L, additional, Pasquali, A, additional, Pastora, L E, additional, Pencheva, G, additional, Pennell, K D, additional, Perego, M, additional, Perkins, W A, additional, Person, M, additional, Peterman, A H, additional, Petersen, R T, additional, Phan, S, additional, Pike, D Q, additional, Prigiobbe, V, additional, Prodanovic, M, additional, Pyrak-Nolte, L J, additional, Quintanilla, H, additional, Raduha, S, additional, Rakowski, C L, additional, Ramos, M J, additional, Reber, J E, additional, Reddy, P R, additional, Requeiro, R A, additional, Richmond, M C, additional, Rinehart, A G, additional, Roach, C M, additional, Roberts, M, additional, Romanak, K D, additional, Romanov, V N, additional, Romero-Gomez, P, additional, Ruoff, R S, additional, Sanford, R A, additional, Santamarina, J C, additional, Santillan, E F U, additional, Sathaye, K J, additional, Scheibe, T D, additional, Schonherr, M, additional, Sen, M K, additional, Senthilnathan, S, additional, Serkowski, J A, additional, Shafiei, M, additional, Shanahan, T M, additional, Shao, S, additional, Sheehan, B, additional, Sheikh, A H El, additional, Shi, Z, additional, Shovkun, I A, additional, Singh, G, additional, Singh, R, additional, Slottke, D T, additional, Sobolik, S, additional, Srinivasan, S, additional, Stadler, G, additional, Stauffer, P H, additional, Stockli, D F, additional, Stormont, J, additional, Strack, E A, additional, Strathmann, T J, additional, Suarez-Rivera, R, additional, Sun, Z, additional, Sun, Y, additional, Sun, A, additional, Sun, T, additional, Sweetser, J D, additional, Taha, M Reda, additional, Tang, H, additional, Tang, Y, additional, Tartakovsky, A M, additional, Tartakovsky, G D, additional, Tavakoli, R, additional, Tavener, S, additional, Tenney, C M, additional, Thomassen, D, additional, Tian, X, additional, Tran, V, additional, Trask, N, additional, Trevisan, L, additional, Truskett, T M, additional, Tsotsis, T T, additional, Turner, D Z, additional, Ureña-Benavides, E E, additional, Valocchi, A J, additional, Vohralik, M, additional, Wang, L, additional, Wang, W, additional, Wang, B, additional, Wang, W H, additional, Wang, Y, additional, Wen, B, additional, Werth, C J, additional, Wheeler, M, additional, White, D, additional, Wick, T, additional, Wietsma, T W, additional, Wildey, T, additional, Wilson, A, additional, Wilson, Jennifer, additional, Wolfe, W, additional, Worthen, A J, additional, Xiao, H, additional, Xue, Z, additional, Xue, G, additional, Yang, C, additional, Yang, X, additional, Yoon, H, additional, Yoon, K Y, additional, Yotov, I A, additional, Youl, A, additional, Youl, K, additional, Yu, G, additional, Zhang, L, additional, Zhang, C, additional, Zhang, R, additional, Zhen, T, additional, and Zhu, W, additional

Published
2019
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15. Computer-Assisted Ankle Joint Arthroplasty Using Bio-engineered Autografts

Author

Sidler, R., Köstler, W., Bardyn, T., Styner, M. A., Südkamp, N., Nolte, L., Ballester, M. Á. González, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Duncan, James S., editor, and Gerig, Guido, editor

Published
2005
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18. Interactions across interfaces between Ordinary Portland Cement (OPC) paste and oil shale.

Author

Bar-Nes, G., primary, Klein-BenDavid, O., additional, Kosson, D., additional, Gruber, C, additional, Taylor, Autumn, additional, Brown, K, additional, DeLapp, R, additional, Brown, L, additional, Ayers, J., additional, Meeussen, J., additional, Matteo, Edward, additional, Jove-Colon, Carlos, additional, Mitchell, Chven, additional, and Pyrak-Nolte, L., additional

Published
2022
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31. Computer-assisted insertion of pedicle screws

Author

Li, Qing Hang, Holdener, Hans J., Zamorano, Lucia, King, Paul, Jiang, Zhaowei, Vinas, Federico C., Nolte, L., Visarius, H., Diaz, Fernando, Goos, Gerhard, editor, Hartmanis, Juris, editor, van Leeuwen, Jan, editor, Höhne, Karl Heinz, editor, and Kikinis, Ron, editor

Published
1996
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32. Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons

Author

Schinke, C., Vallone, V.F., Ivanov, A., Peng, Y., Körtvelyessy, P., Nolte, L., Huehnchen, P., Beule, D., Stachelscheid, H., Boehmerle, W., and Endres, M.

Subjects
Technology Platforms
Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent, potentially irreversible adverse effect of cytotoxic chemotherapy often leading to a reduction or discontinuation of treatment which negatively impacts patients' prognosis. To date, however, neither predictive biomarkers nor preventive treatments for CIPN are available, which is partially due to a lack of suitable experimental models. We therefore aimed to evaluate whether sensory neurons derived from induced pluripotent stem cells (iPSC-DSN) can serve as human disease model system for CIPN. Treatment of iPSC-DSN for 24 h with the neurotoxic drugs paclitaxel, bortezomib, vincristine and cisplatin led to axonal blebbing and a dose dependent decline of cell viability in clinically relevant IC(50) ranges, which was not observed for the non-neurotoxic compounds doxorubicin and 5-fluorouracil. Paclitaxel treatment effects were less pronounced after 24 h but prominent when treatment was applied for 72 h. Global transcriptome analyses performed at 24 h, i.e. before paclitaxel-induced cell death occurred, revealed the differential expression of genes of neuronal injury, cellular stress response, and sterol pathways. We further evaluated if known neuroprotective strategies can be reproduced in iPSC-DSN and observed protective effects of lithium replicating findings from rodent dorsal root ganglia cells. Comparing sensory neurons derived from two different healthy donors, we found preliminary evidence that these cell lines react differentially to neurotoxic drugs as expected from the variable presentation of CIPN in patients. In conclusion, iPSC-DSN are a promising platform to study the pathogenesis of CIPN and to evaluate neuroprotective treatment strategies. In the future, the application of patient-specific iPSC-DSN could open new avenues for personalized medicine with individual risk prediction, choice of chemotherapeutic compounds and preventive treatments.

Published
2021

46. Abstracts der 3. Gemeinsamen Brachytherapiekonferenz SASRO/DEGRO/OEGRO

Author

Ott, O. J., Strnad, V., Pötter, R., Hammer, J., Hildebrandt, G., Resch, A., Kovács, G., Beckmann, M. W., Sauer, R., Niehoff, P., Polgar, C., Ostertag, H., Major, T., Eidtmann, H., Jonat, W., Kimmig, B., Roddiger, S. J., Kolotas, C., Kuner, R. P., Martin, T., Kurek, R., Baltas, D., Rogge, B., Kautschur, H., Hoffmann, G., Pollow, B., Kontova, M., Zamboglou, N., Ott, O., Lotter, M., Gallino, A., Mahler, F., Niewald, M., Jafari, F., Hennen, B., Wisser, L., Fleckenstein, J., Rübe, Ch., Böhm, M., Micke, O., Wagner, W., Schäfer, U., Willich, N., Greiner, R. H., Pallas, A., Pajic, B., Collen, T., Meurer, N., Töpfer, M., Ries, G., Leutloff, U., Frei, S., Warszawski, A., Baumann, R., Möller, T., Niedermeyer, J., Karstens, J. H., Gripp, S., Muskalla, K., Pulte, T., Ohmann, C., Röddiger, S., Dannenberg, T., Tunn, U. W., Dimopoulos, J., Schard, G., Kirisits, C., Lang, S., Goldner, G., Wachter, S., Wachter-Gerstner, N., Helbich, T., Weise, C., Bendel, M., Kocher, M., Müller, R.-P., Engelmann, U., Aebersold, D. M., Isaak, B., Vetterli, D., Kemmerling, L., Thalmann, G., Behrensmeier, F., Mini, R., Baier, K., Wulf, J., Nürnberg, N., Egberts, J., Galalae, R., Maurer, U., Maurer, G., Lang, K., Zumbé, J., Block, T., Czempiel, H., Machtens, S., Ponholzer, A., Riedl, A., Oismüller, R., Somay, C., Hawliczek, R., Maier, U., Madersbacher, S., Hoinkis, C., Winkler, C., Lehmann, D., Hakenberg, O., Herrmann, T., Messer, P. M., Gottfried, H.-W., Schneider, E., Röttinger, E. M., Haverkamp, U., Prümer, B. A., Krause, K., Tschuschke, C., Blumberg, J., Benkel, P., Fischedick, A. R., Geiger, M. H., Hoffmann, T. C., Reible, M., Meyer-Venter, R., Plümpe, A., Bund, J., Dreikorn, K., Staar, S., Horn, G., Zimmermann, J. S., Pfeiffer, D., Tauber, R., Bruns, T., Osieka, R., Blumstein, N. M., Schmidt, W., Büchler, F., Prikler, L., Seelentag, W., Koch, K., Haker, H., König, F., Oesterwitz, H., Schütz, R., Stahl, H., Ullmann, A., Sztankay, A., Rachbauer, F., Kreczy, A., Sununu, T., Bach, C., Nogler, M., Krismer, M., Eichberger, P., Schiestl, B., Lukas, P., Wolf, A., Hänsgen, G., Dunst, J., Utzig, D., Knocke-Abulesz, T. H., Baldass, M., Kucera, H., Weitmann, H. D., Waldhäusl, C., Nechvile, E., Knocke, T.-H., Georg, D., Krause, U., Fröhlich, D., Glatzel, M., Büntzel, J., Schröder, D., Küttner, K., Pfreundnerx, L., Willner, J., Bratengeier, K., Schwager, K., Hoppe, F., Schwab, F., Sauer, O., Flentje, M., Tselis, N., Schneider, O., Stückle, C. A., Adamietz, I. A., Weitman, H. D., Tepel, J., Schmid, A., Kohr, P., Kremer, B., Moh’d, Suleiman, Frey, J. G., Tschopp, J. M., Bieri, S., Jeszensky, D., Liebsch, N., Seelentag, W. W., Karle, H., Jacob-Heutmann, D., Born, C., Mohr, W., Kutzner, J., Thelen, M., Blochberger, P., Wächtler, M., Kaulich, T. W., Zurheide, J., Haug, T., Nüsslin, F., Bamberg, M., Curschmann, J., Kranzbühler, H., Greiner, R., Cossmann, P. H., Caversaccio, M., Pappas, I., and Nolte, L. P.

Published
2004
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