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1. Die EFSUMB-Leitlinien und Empfehlungen für den klinischen Einsatz des kontrastverstärkten Ultraschalls (CEUS) bei nicht-hepatischen Anwendungen: Update 2017 (Kurzversion)

Author

Sidhu, P.S., Cantisani, V., Dietrich, C.F., Gilja, O.H., Saftoiu, A., Bartels, E., Bertolotto, M., Calliada, F., Clevert, D.-A., Cosgrove, D., Deganello, A., D'Onofrio, M., Drudi, F.M., Freeman, S., Harvey, C., Jenssen, C., Jung, E.-M., Klauser, A.S., Lassau, N., Meloni, M.F., Leen, E., Nicolau, C., Nolsoe, C., Piscaglia, F., Prada, F., Prosch, H., Radzina, M., Savelli, L., Weskott, H.-P., Wijkstra, H., Signal Processing Systems, and Biomedical Diagnostics Lab

Subjects
urinary tract, Adult, Male, neurology, Liver Neoplasms, head/neck, Sulfur Hexafluoride, Contrast Media, musculoskeletal system, Liver/diagnostic imaging, head, Image Enhancement, neck, vascular, Ultrasonography/standards, Practice Guidelines as Topic, Humans, Female, Phospholipids
Abstract

The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.

Published
2018

2. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Short Version)

Author

Sidhu, P.S., Cantisani, V., Dietrich, C.F., Gilja, O.H., Saftoiu, A., Bartels, E., Bertolotto, M., Calliada, F., Clevert, D.-A., Cosgrove, D., Deganello, A., D'Onofrio, M., Drudi, F.M., Freeman, S., Harvey, C., Jenssen, C., Jung, E.-M., Klauser, A.S., Lassau, N., Meloni, M.F., Leen, E., Nicolau, C., Nolsoe, C., Piscaglia, F., Prada, F., Prosch, H., Radzina, M., Savelli, L., Weskott, H.-P., Wijkstra, H., Sidhu, P.S., Cantisani, V., Dietrich, C.F., Gilja, O.H., Saftoiu, A., Bartels, E., Bertolotto, M., Calliada, F., Clevert, D.-A., Cosgrove, D., Deganello, A., D'Onofrio, M., Drudi, F.M., Freeman, S., Harvey, C., Jenssen, C., Jung, E.-M., Klauser, A.S., Lassau, N., Meloni, M.F., Leen, E., Nicolau, C., Nolsoe, C., Piscaglia, F., Prada, F., Prosch, H., Radzina, M., Savelli, L., Weskott, H.-P., and Wijkstra, H.

Abstract

The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.

Published
2018

3. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part I. General Aspects (Short Version)

Author

Lorentzen, T, Nolsoe, C. P., Ewertsen, C., Nielsen, M. B., Leen, E., Havre, R. F., Gritzmann, N., Brkljacic, B., Nürnberg, D., Kabaalioglu, A., Strobel, D., Jenssen, C., Gilja, O. H., Sidhu, P. S., Dietrich, C. F., PISCAGLIA, FABIO, Lorentzen, T, Nolsoe, C.P., Ewertsen, C., Nielsen, M.B., Leen, E., Havre, R.F., Gritzmann, N., Brkljacic, B., Nürnberg, D., Kabaalioglu, A., Strobel, D., Jenssen, C., Piscaglia, F., Gilja, O.H., Sidhu, P.S., and Dietrich, C.F.

Subjects
safety, Image-Guided Biopsy, hygiene, ultrasound guidance, Radiology, Nuclear Medicine and Imaging, Germany, microbiology, Biopsy, Needle, Contrast Media, Humans, Ultrasonography, Doppler, guideline, Ultrasonography, Interventional
Abstract

This is the first part of the Guidelines on Interventional Ultrasound of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) and covers all general aspects of ultrasound-guided procedures (short version; the long version is published online).

Published
2015

4. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part v

Author

Fusaroli, P, Jenssen, C., Hocke, Martine, Burmester, E, Buscarini, E, Havre, R. F., Ignee, A, Saftoiu, Adrian, Vilmann, P., Nolsoe, C. P., Nürnberg, D, D'Onofrio, M., Gilja, O H, Lorentzen, T., Piscaglia, F., Sidhu, P S, Dietrich, C F, Fusaroli, P, Jenssen, C., Hocke, Martine, Burmester, E, Buscarini, E, Havre, R. F., Ignee, A, Saftoiu, Adrian, Vilmann, P., Nolsoe, C. P., Nürnberg, D, D'Onofrio, M., Gilja, O H, Lorentzen, T., Piscaglia, F., Sidhu, P S, and Dietrich, C F

Abstract

The fifth section of the Guidelines on Interventional Ultrasound (INVUS) of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) assesses the evidence for all the categories of endoscopic ultrasound-guided treatment reported to date. Celiac plexus neurolysis and block, vascular intervention, drainage of fluid collections, drainage of biliary and pancreatic ducts, and experimental tumor ablation techniques are discussed. For each topic, all current evidence has been extensively analyzed and summarized into major recommendations for reader consultation in clinical practice (long version).

Published
2016

5. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part v - EUS-Guided Therapeutic Interventions (short version)

Author

Fusaroli, P, Jenssen, C., Hocke, Martine, Burmester, E, Buscarini, E, Havre, R. F., Ignee, A, Saftoiu, A., Vilmann, P., Nolsoe, C. P., Nürnberg, D, D'Onofrio, M., Gilja, O H, Lorentzen, T., Piscaglia, F., Sidhu, P S, Dietrich, C F, Fusaroli, P, Jenssen, C., Hocke, Martine, Burmester, E, Buscarini, E, Havre, R. F., Ignee, A, Saftoiu, A., Vilmann, P., Nolsoe, C. P., Nürnberg, D, D'Onofrio, M., Gilja, O H, Lorentzen, T., Piscaglia, F., Sidhu, P S, and Dietrich, C F

Abstract

The fifth section of the Guidelines on Interventional Ultrasound (INVUS) of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) assesses the evidence for all the categories of endoscopic ultrasound-guided treatment reported to date. Celiac plexus neurolysis and block, vascular intervention, drainage of fluid collections, drainage of biliary and pancreatic ducts, and experimental tumor ablation techniques are discussed. For each topic, all current evidence has been extensively analyzed and summarized into major recommendations for reader consultation (short version; the long version is published online).

Published
2016

6. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part III - Abdominal Treatment Procedures (Short Version)

Author

Dietrich, Christoph F, Lorentzen, T., Appelbaum, L., Buscarini, E, Cantisani, V., Correas, J M, Cui, X. W., D'Onofrio, M., Gilja, O H, Hocke, Martine, Ignee, A, Jenssen, C., Kabaalioʇlu, A., Leen, E., Nicolau, Jose C, Nolsoe, C. P., Radzina, M., Serra, C., Sidhu, P S, Sparchez, Z., Piscaglia, F., Dietrich, Christoph F, Lorentzen, T., Appelbaum, L., Buscarini, E, Cantisani, V., Correas, J M, Cui, X. W., D'Onofrio, M., Gilja, O H, Hocke, Martine, Ignee, A, Jenssen, C., Kabaalioʇlu, A., Leen, E., Nicolau, Jose C, Nolsoe, C. P., Radzina, M., Serra, C., Sidhu, P S, Sparchez, Z., and Piscaglia, F.

Abstract

The third part of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on Interventional Ultrasound assesses the evidence for ultrasound-guided and assisted interventions in abdominal treatment procedures. Recommendations for clinical practice are presented covering indications, contraindications, safety and efficacy of the broad variety of these techniques. In particular, drainage of abscesses and fluid collections, interventional tumor ablation techniques, interventional treatment of symptomatic cysts and echinococcosis, percutaneous transhepatic cholangiography and drainage, percutaneous gastrostomy, urinary bladder drainage, and nephrostomy are addressed (short version; a long version is published online).

Published
2016

7. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part III - Abdominal Treatment Procedures (Long Version)

Author

Dietrich, Christoph F, Lorentzen, T., Appelbaum, L., Buscarini, E, Cantisani, V., Correas, J M, Cui, X. W., D'Onofrio, M., Gilja, O H, Hocke, Martine, Ignee, A, Jenssen, C., Kabaalioʇlu, A., Leen, E., Nicolau, Jose C, Nolsoe, C. P., Radzina, M., Serra, C., Sidhu, P S, Sparchez, Z., Piscaglia, F., Dietrich, Christoph F, Lorentzen, T., Appelbaum, L., Buscarini, E, Cantisani, V., Correas, J M, Cui, X. W., D'Onofrio, M., Gilja, O H, Hocke, Martine, Ignee, A, Jenssen, C., Kabaalioʇlu, A., Leen, E., Nicolau, Jose C, Nolsoe, C. P., Radzina, M., Serra, C., Sidhu, P S, Sparchez, Z., and Piscaglia, F.

Abstract

The third part of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on Interventional Ultrasound (INVUS) assesses the evidence for ultrasound-guided and assisted interventions in abdominal treatment procedures. Recommendations for clinical practice are presented covering indications, contraindications, and safe and effective performance of the broad variety of these techniques. In particular, drainage of abscesses and fluid collections, interventional tumor ablation techniques, interventional treatment of symptomatic cysts and echinococcosis, percutaneous transhepatic cholangiography and drainage, percutaneous gastrostomy, urinary bladder drainage, and nephrostomy are addressed (long version).

Published
2016

8. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part II Diagnostic Ultrasound-Guided Interventional Procedures (Short Version)

Author

Sidhu, P. S., Brabrand, K., Cantisani, V., Correas, J. M., Cui, X. W., D'Onofrio, M., Essig, M., Freeman, S., Gilja, O. H., Gritzmann, N., Havre, R. F., Ignee, A., Jenssen, C., Kabaalioglu, A., Lorentzen, T., Mohaupt, M., Nicolau, C., Nolsoe, C. P., Nuernberg, D., Radzina, M., Saftoiu, A., Serra, C., Sparchez, Z., Sporea, I., Dietrich, C. F., Sidhu, P. S., Brabrand, K., Cantisani, V., Correas, J. M., Cui, X. W., D'Onofrio, M., Essig, M., Freeman, S., Gilja, O. H., Gritzmann, N., Havre, R. F., Ignee, A., Jenssen, C., Kabaalioglu, A., Lorentzen, T., Mohaupt, M., Nicolau, C., Nolsoe, C. P., Nuernberg, D., Radzina, M., Saftoiu, A., Serra, C., Sparchez, Z., Sporea, I., and Dietrich, C. F.

Published
2015

9. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part II Diagnostic Ultrasound-Guided Interventional Procedures (Long Version)

Author

Sidhu, P. S., Brabrand, K., Cantisani, V., Correas, J. M., Cui, X. W., D'Onofrio, M., Essig, M., Freeman, S., Gilja, O. H., Gritzmann, N., Havre, R. F., Ignee, A., Jenssen, C., Kabaalioglu, A., Lorentzen, T., Mohaupt, M., Nicolau, C., Nolsoe, C. P., Nuernberg, D., Radzina, M., Saftoiu, A., Serra, C., Sparchez, Z., Sporea, I., Dietrich, C. F., Sidhu, P. S., Brabrand, K., Cantisani, V., Correas, J. M., Cui, X. W., D'Onofrio, M., Essig, M., Freeman, S., Gilja, O. H., Gritzmann, N., Havre, R. F., Ignee, A., Jenssen, C., Kabaalioglu, A., Lorentzen, T., Mohaupt, M., Nicolau, C., Nolsoe, C. P., Nuernberg, D., Radzina, M., Saftoiu, A., Serra, C., Sparchez, Z., Sporea, I., and Dietrich, C. F.

Published
2015

10. The EFSUMB Guidelines and Recommendations on the Clinical Practice of Contrast Enhanced Ultrasound (CEUS): Update 2011 on non-hepatic applications

Author

Piscaglia, F., Nolsoe, C., Nolsøe, C., Dietrich, C. f., Cosgrove, D. o., Gilja, O. h., Nielsen, M. b., Albrecht, T., Barozzi, L., Bertolotto, M., Catalano, O., Claudon, M., Clevert, D. a., Correas, J. m., D'Onofrio, M., Bertolotto9, M., Catalano10, O., Claudon11, M., Clevert12, D. a., Correas13, J. m., D’Onofrio14, M., Drudi, Francesco Maria, Eyding, J., Giovannini, M., Hocke, M., Ignee, A., Jung, E. m., Klauser, A. s., Lassau, N., Leen, E., Mathis, G., Saftoiu, A., Seidel, G., Sidhu, P. s., Ter Haar, G., Timmerman, D., Weskott, H. p., Weskott30, H. p., Piscaglia, F., Nolsøe, C., Dietrich, C. F., Cosgrove, D. O., Gilja, O. H., Nielsen, M. B., Albrecht, T., Barozzi, L., Bertolotto, Michele, Catalano, O., Claudon, M., Clevert, D. A., Correas, J. M., D’Onofrio, M., Drudi, F. M., Eyding, J., Giovannini, M., Hocke, M., Ignee, A., Jung, E. M., Klauser, A. S., Lassau, N., Leen, E., Mathis, G., Saftoiu, A., Seidel, G., Sidhu, P. S., Haar G., Ter, Timmerman, D., Weskott, H. P., Piscaglia F, Nolsøe C, Dietrich CF, Cosgrove DO, Gilja OH, Bachmann Nielsen M, Albrecht T, Barozzi L, Bertolotto M, Catalano O, Claudon M, Clevert DA, Correas JM, D'Onofrio M, Drudi FM, Eyding J, Giovannini M, Hocke M, Ignee A, Jung EM, Klauser AS, Lassau N, Leen E, Mathis G, Saftoiu A, Seidel G, Sidhu PS, Haar GT, Timmerman D, and Weskott HP.

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, EFSUMB Guidelines, Contrast Enhanced Ultrasound (CEUS), Update 2011, non-hepatic applications, MEDLINE, Sulfur Hexafluoride, Contrast Media, GUIDELINES, Sensitivity and Specificity, Endosonography, Ultrasonography/methods CEUS, Guidelines recommendations, Polysaccharides, Albumins, medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, Child, Phospholipids, Ultrasonography, Fluorocarbons, Therapeutic ultrasound, business.industry, Ultrasonography, Doppler, Image enhancement, Image Enhancement, Ultrasonography doppler, Clinical Practice, Liver, CEUS, Female, Radiology, business, Contrast-enhanced ultrasound
Abstract

[No abstract available]

Published
2012

11. Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) - Update 2008

Author

Claudon, M., Cosgrove, D., Albrecht, T., Bolondi, L., Bosio, M., Calliada, F., Correas, J.M., Darge, K., Dietrich, C., D'Onofrio, M., Evans, D.H., Filice, C., Greiner, L., Jager, K., Jong, N. de, Leen, E., Lencioni, R., Lindsell, D., Martegani, A., Meairs, S., Nolsoe, C., Piscaglia, F., Ricci, P., Seidel, G., Skjoldbye, B., Solbiati, L., Thorelius, L., Tranquart, F., Weskott, H.P., Whittingham, T., Claudon, M., Cosgrove, D., Albrecht, T., Bolondi, L., Bosio, M., Calliada, F., Correas, J.M., Darge, K., Dietrich, C., D'Onofrio, M., Evans, D.H., Filice, C., Greiner, L., Jager, K., Jong, N. de, Leen, E., Lencioni, R., Lindsell, D., Martegani, A., Meairs, S., Nolsoe, C., Piscaglia, F., Ricci, P., Seidel, G., Skjoldbye, B., Solbiati, L., Thorelius, L., Tranquart, F., Weskott, H.P., and Whittingham, T.

Abstract

Udgivelsesdato: 2008/2

Published
2008

12. Is 0.6T magnetic resonance mammography adequate in the detection of breast cancer?

Author

Marklund, M., Moller, J. M., Burchardt, A. J., Bentzon, N., Balslev, E., Sletting, S., Nolsoe, C. P., Marklund, M., Moller, J. M., Burchardt, A. J., Bentzon, N., Balslev, E., Sletting, S., and Nolsoe, C. P.

Abstract

Purpose: To evaluate whether relevant diagnostic information can be achieved when using magnetic resonance mammography (MRM) on midfield as a supplement to conventional imaging and clinical examination in women with primary breast cancer. Material and Methods: 30 women (55 breasts containing 49 malignant tumors) planned for uni or bilateral mastectomy were examined with dynamic MRM on midfield, 0.6T. The women were examined with mammography (M) and ultrasonography (US) prior to MRM. The descriptions of the conventional examinations were evaluated retrospectively, whereas the MRM was evaluated prospectively, with knowledge of the M+US findings. Imaging findings suggesting malignancy were registered and correlated with pathology after mastectomy. A home-made rating system for evaluation of the detected lesions was tested. Results: MRM detected seven additional malignant tumors, failed to detect three lesions and characterized four as gray-zone lesions according to the rating system. Sensitivity of finding the tumors with M+US was 79.0%, with a PPV for malignant tumors of 84.4%. One breast in which MRM found a malignant tumor had not initially been examined with US. Sensitivity with MRM was 91.6%, with a positive predictive value of malignant tumors of 97.7%. Conclusion: MRM on mid-field seems to improve the detection of cancers when used as a supplement to M+US in women with primary breast cancer. We believe that the results are fair compared to MRM on high-field, although further research and refinement are needed.

Published
2006

19. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Short Version)

Author

Chris J Harvey, Paul S. Sidhu, Luca Savelli, Carlos Nicolau, Fabio Piscaglia, A. Saftoiu, Vito Cantisani, Eva Bartels, Annamaria Deganello, Michele Bertolotto, Francesco Prada, Hessel Wijkstra, Simon Freeman, David O. Cosgrove, Christian Pállson Nolsøe, Ernst Michael Jung, Maria Franca Meloni, Mirko D'Onofrio, Francesco Maria Drudi, Helmut Prosch, Christian Jenssen, Hans Peter Weskott, Maija Radzina, Christoph F. Dietrich, Dirk-André Clevert, Edward Leen, Nathalie Lassau, Fabrizio Calliada, Odd Helge Gilja, Andrea Klauser, Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D'Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, Wijkstra H., Sidhu, P. S., Cantisani, V., Dietrich, C. F., Gilja, O. H., Saftoiu, A., Bartels, E., Bertolotto, M., Calliada, F., Clevert, D. -A., Cosgrove, D., Deganello, A., D'Onofrio, M., Drudi, F. M., Freeman, S., Harvey, C., Jenssen, C., Jung, E. -M., Klauser, A. S., Lassau, N., Meloni, M. F., Leen, E., Nicolau, C., Nolsoe, C., Piscaglia, F., Prada, F., Prosch, H., Radzina, M., Savelli, L., Weskott, H. -P., and Wijkstra, H.

Subjects
EFSUMB Guidelines, vascular, urinary tract, neurology, musculoskeletal system, head, neck, Adult, Male, head/neck, Sulfur Hexafluoride, Contrast Media, vascular, Female, Humans, Image Enhancement, Liver, Liver Neoplasms, Phospholipids, Ultrasonography, Practice Guidelines as Topic, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, EFSUMB Guidelines, Medicine, Radiology, Nuclear Medicine and imaging, business.industry, Ultrasound, Head neck, Image enhancement, Phospholipid, Liver Neoplasm, business, Nuclear medicine, Human
Abstract

The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.Die aktualisierte Version der EFSUMB-Leitlinien für die Anwendung von nicht-hepatischem kontrastverstärktem Ultraschall (CEUS) befasst sich mit der Verwendung von Mikrobläschen Ultraschall-Kontrastmitteln außerhalb der Leber in zahlreichen etablierten und neu entstehenden Einsatzbereichen.

Published
2018

20. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)

Author

Chris J Harvey, Nathalie Lassau, Dirk-André Clevert, Paul S. Sidhu, Hessel Wijkstra, Fabio Piscaglia, Edward Leen, David O. Cosgrove, Annamaria Deganello, H. Prosch, Adrian Saftoiu, Michele Bertolotto, Fabrizio Calliada, Christoph F. Dietrich, Simon Freeman, Odd Helge Gilja, Andrea Klauser, Ernst Michael Jung, Luca Savelli, Francesco Prada, Mirko D'Onofrio, Christian Pállson Nolsøe, Vito Cantisani, Carlos Nicolau, Christian Jenssen, Eva Bartels, Maria Franca Meloni, Hans Peter Weskott, Francesco Maria Drudi, Maija Radzina, Sidhu, P. S., Cantisani, V., Dietrich, C. F., Gilja, O. H., Saftoiu, A., Bartels, E., Bertolotto, M., Calliada, F., Clevert, D. -A., Cosgrove, D., Deganello, A., D'Onofrio, M., Drudi, F. M., Freeman, S., Harvey, C., Jenssen, C., Jung, E. -M., Klauser, A. S., Lassau, N., Meloni, M. F., Leen, E., Nicolau, C., Nolsoe, C., Piscaglia, F., Prada, F., Prosch, H., Radzina, M., Savelli, L., Weskott, H. -P., Wijkstra, H., and Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D'Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, Wijkstra H

Subjects
Adult, Male, medicine.medical_specialty, head/neck, Sulfur Hexafluoride, Contrast Media, musculoskeletal system, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, vascular, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Medical physics, Phospholipids, Ultrasonography, neurology, urinary tract, business.industry, Liver Neoplasms, Ultrasound, Head neck, EFSUMB guidelines, Image enhancement, Image Enhancement, EFSUMB guidelines , non-hepatic contrast-enhanced ultrasound (CEUS), non-hepatic contrast-enhanced ultrasound (CEUS), Clinical Practice, Female, Liver, Practice Guidelines as Topic, Phospholipid, Liver Neoplasm, 030220 oncology & carcinogenesis, business, Contrast-enhanced ultrasound, Human
Abstract

The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.Die aktualisierte Version der EFSUMB-Leitlinien für die Anwendung von nicht-hepatischem kontrastverstärktem Ultraschall (CEUS) befasst sich mit der Verwendung von Mikrobläschen Ultraschall-Kontrastmitteln außerhalb der Leber in zahlreichen etablierten und neu entstehenden Einsatzbereichen.

Published
2018

21. EFSUMB Guidelines on Interventional Ultrasound (INVUS), Part III - Abdominal Treatment Procedures (Long Version)

Author

C. Dietrich, T. Lorentzen, L. Appelbaum, E. Buscarini, V. Cantisani, J. Correas, X. Cui, M. D’Onofrio, O. Gilja, M. Hocke, A. Ignee, C. Jenssen, A. Kabaalioğlu, E. Leen, C. Nicolau, C. Nolsøe, M. Radzina, C. Serra, P. Sidhu, Z. Sparchez, F. Piscaglia, Dietrich, Christoph F., Lorentzen, T., Appelbaum, L., Buscarini, E., Cantisani, V., Correas, J. M., Cui, X. W., D'Onofrio, Mario, Gilja, O. H., Hocke, M., Ignee, A., Jenssen, C., Kabaalioʇlu, A., Leen, E., Nicolau, C., Nolsoe, C. P., Radzina, M., Serra, Carla, Sidhu, P. S., Sparchez, Z., and Piscaglia, Fabio

Subjects
safety, Radiology, Nuclear Medicine and Imaging, Abdominal Abscess, abscess, cysts, Colorectal Neoplasm, Germany, Abdomen, Nephrostomy, Percutaneou, Sclerotherapy, Humans, Paracentesis, absce, liver metastase, Cholecystostomy, Paracentesi, Ultrasonography, Interventional, Societies, Medical, Nephrostomy, Percutaneous, cyst, Gastrostomy, ultrasound guidance, Evidence-Based Medicine, Liver Diseases, Liver Disease, Liver Neoplasms, Abdominal Absce, Palliative Care, Kidney Neoplasm, drainage, guideline, hepatocellular carcinoma, liver metastases, radio frequency ablation, Combined Modality Therapy, Kidney Neoplasms, Liver Neoplasm, guideline, ultrasound guidance, abscess, hepatocellular carcinoma, liver metastases, cysts, radio frequency ablation, drainage, safety, Colorectal Neoplasms, Human
Abstract

The third part of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on Interventional Ultrasound (INVUS) assesses the evidence for ultrasound-guided and assisted interventions in abdominal treatment procedures. Recommendations for clinical practice are presented covering indications, contraindications, and safe and effective performance of the broad variety of these techniques. In particular, drainage of abscesses and fluid collections, interventional tumor ablation techniques, interventional treatment of symptomatic cysts and echinococcosis, percutaneous transhepatic cholangiography and drainage, percutaneous gastrostomy, urinary bladder drainage, and nephrostomy are addressed (long version).

Published
2016

22. EFSUMB guidelines on interventional ultrasound (INVUS), Part III - abdominal treatment procedures (short version)

Author

L. Appelbaum, Adnan Kabaalioglu, Carlos Nicolau, Zeno Sparchez, Fabio Piscaglia, Jean Michel Correas, Paul S. Sidhu, T. Lorentzen, A. Ignee, Edward Leen, Christian Pállson Nolsøe, Carla Serra, Vito Cantisani, Mirko D'Onofrio, Christoph F. Dietrich, Xin-Wu Cui, Michael Hocke, Odd Helge Gilja, Maija Radzina, Christian Jenssen, Elisabetta Buscarini, Dietrich, Christoph F., Lorentzen, T., Appelbaum, L., Buscarini, E., Cantisani, V., Correas, J. M., Cui, X. W., D'Onofrio, Mario, Gilja, O. H., Hocke, M., Ignee, A., Jenssen, C., Kabaalioʇlu, A., Leen, E., Nicolau, C., Nolsoe, C. P., Radzina, M., Serra, Carla, Sidhu, P. S., Sparchez, Z., and Piscaglia, Fabio

Subjects
Radiology, Nuclear Medicine and Imaging, Technology, Palliative care, Quality Assurance, Health Care, Hepatocellular carcinoma, medicine.medical_treatment, Abdominal Neoplasm, Guideline, Percutaneous transhepatic cholangiography, Liver metastases, Cholangiography, Germany, Nephrostomy, Percutaneou, Abdomen, Sclerotherapy, Percutaneous, Ultrasonography, Gastrostomy, Nephrostomy, medicine.diagnostic_test, Interventional, Cysts, Radiology, Nuclear Medicine & Medical Imaging, Liver Neoplasms, Abscess, Nuclear Medicine & Medical Imaging, Treatment Outcome, Liver Neoplasm, Cholecystostomy, Drainage, Radiology, Patient Safety, Safety, Life Sciences & Biomedicine, Human, medicine.medical_specialty, Abdominal Abscess, Urinary Bladder, Ultrasound guidance, medicine, absce, Humans, liver metastase, Ultrasonography, Interventional, Nephrostomy, Percutaneous, Science & Technology, business.industry, Abdominal Neoplasms, Abdominal Absce, Radiofrequency ablation, abscess, drainage, guideline, hepatocellular carcinoma, liver metastases, radiofrequency ablation, safety, ultrasound guidance, Evidence-based medicine, Acoustics, Health Care, Cyst, business, Quality Assurance
Abstract

The third part of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) Guidelines on Interventional Ultrasound assesses the evidence for ultrasound-guided and assisted interventions in abdominal treatment procedures. Recommendations for clinical practice are presented covering indications, contraindications, safety and efficacy of the broad variety of these techniques. In particular, drainage of abscesses and fluid collections, interventional tumor ablation techniques, interventional treatment of symptomatic cysts and echinococcosis, percutaneous transhepatic cholangiography and drainage, percutaneous gastrostomy, urinary bladder drainage, and nephrostomy are addressed (short version; a long version is published online).

Published
2016

23. History of Ultrasound in Medicine from its birth to date (2022), on occasion of the 50 Years Anniversary of EFSUMB. A publication of the European Federation of Societies for Ultrasound In Medicine and Biology (EFSUMB), designed to record the historical development of medical ultrasound.

Author

Dietrich CF, Bolondi L, Duck F, Evans DH, Ewertsen C, Fraser AG, Gilja OH, Jenssen C, Merz E, Nolsoe C, Nürnberg D, Lutz H, Piscaglia F, Saftoiu A, Vilmann P, Dong Y, and Hill CRK

Subjects
Humans, Contrast Media, Societies, Medical, Ultrasonography methods, Anniversaries and Special Events, Ultrasonography, Interventional
Abstract

The history of the European Federation of Societies in Ultrasound in Medicine and Biology (EFSUMB) is closely related to the general history of ultrasound. In the presented paper the physical background and history of technologies including A-mode, Time motion or M-mode, 2D Imaging (B-mode) are summarized. In addition, ultrasound tissue characterization, Doppler ultrasound, 3D and 4D ultrasound, intracavitary and endoscopic ultrasound, interventional ultrasound, ultrasonic therapy, contrast enhanced ultrasound (CEUS) and key developments in echocardiography are discussed.

Published
2022
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24. Randomized Phase II Study of Nivolumab With or Without Ipilimumab Combined With Stereotactic Body Radiotherapy for Refractory Metastatic Pancreatic Cancer (CheckPAC).

Author

Chen IM, Johansen JS, Theile S, Hjaltelin JX, Novitski SI, Brunak S, Hasselby JP, Willemoe GL, Lorentzen T, Madsen K, Jensen BV, Wilken EE, Geertsen P, Behrens C, Nolsoe C, Hermann KL, Svane IM, and Nielsen D

Subjects
Antineoplastic Combined Chemotherapy Protocols therapeutic use, C-Reactive Protein, Humans, Interleukin-6, Interleukin-8, Ipilimumab adverse effects, Ligands, Nivolumab adverse effects, Pancreatic Neoplasms drug therapy, Pancreatic Neoplasms radiotherapy, Radiosurgery adverse effects
Abstract

Purpose: To evaluate the clinical benefit of nivolumab with or without ipilimumab in combination with stereotactic body radiotherapy (SBRT) in patients with refractory metastatic pancreatic cancer (mPC)., Methods: Between November 2016 and December 2019, patients with refractory mPC were randomly assigned 1:1 to SBRT of 15 Gy with nivolumab or nivolumab/ipilimumab stratified by performance status (ClinicalTrials.gov identifier: NCT02866383). The primary end point was the clinical benefit rate (CBR), defined as the percentage of patients with complete or partial response (PR) or stable disease, according to RECIST 1.1. Simon's 2-stage phase II optimal design was used independently for both arms, with CBR determining expansion to the second stage. Secondary end points included safety, response rate, duration of response, progression-free survival, and overall survival. Exploratory analyses included biomarkers related to the benefits., Results: Eighty-four patients (41 SBRT/nivolumab and 43 SBRT/nivolumab/ipilimumab) received at least one dose of study treatment. CBR was 17.1% (8.0 to 30.6) for patients receiving SBRT/nivolumab and 37.2% (24.0 to 52.1) for SBRT/nivolumab/ipilimumab. PR was observed in one patient receiving SBRT/nivolumab and lasted for 4.6 months. Six patients receiving SBRT/nivolumab/ipilimumab achieved a PR with a median duration of response of 5.4 months (4.2 to not reached). Grade 3 or higher treatment-related adverse events occurred in 10 (24.4%) and 13 (30.2%) patients in the SBRT/nivolumab and SBRT/nivolumab/ipilimumab groups, respectively. Programmed cell death ligand-1 expression by tumor proportion score or combined positivity score of ≥ 1% was not associated with clinical benefits. On-treatment decreased serum interleukin-6, interleukin-8, and C-reactive protein levels were associated with better overall survival., Conclusion: Clinically meaningful antitumor activity and favorable safety profiles were demonstrated after treatment with SBRT/nivolumab/ipilimumab in patients with refractory mPC. However, the contribution from SBRT is unknown. Further studies are warranted.

Published
2022
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25. Electroporation and Immunotherapy-Unleashing the Abscopal Effect.

Author

Justesen TF, Orhan A, Raskov H, Nolsoe C, and Gögenur I

Abstract

The discovery of electroporation in 1968 has led to the development of electrochemotherapy (ECT) and irreversible electroporation (IRE). ECT and IRE have been established as treatments of cutaneous and subcutaneous tumors and locally advanced pancreatic cancer, respectively. Interestingly, the treatment modalities have been shown to elicit immunogenic cell death, which in turn can induce an immune response towards the tumor cells. With the dawn of the immunotherapy era, the potential of combining ECT and IRE with immunotherapy has led to the launch of numerous studies. Data from the first clinical trials are promising, and new combination regimes might change the way we treat tumors characterized by low immunogenicity and high levels of immunosuppression, such as melanoma and pancreatic cancer. In this review we will give an introduction to ECT and IRE and discuss the impact on the immune system. Additionally, we will present the results of clinical and preclinical trials, investigating the combination of electroporation modalities and immunotherapy.

Published
2022
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26. Clinical Applications of Contrast-Enhanced Thoracic Ultrasound (CETUS) Compared to Standard Reference Tests: A Systematic Review.

Author

Jacobsen N, Pietersen PI, Nolsoe C, Konge L, Graumann O, and Laursen CB

Subjects
Contrast Media, Humans, Thorax diagnostic imaging, Ultrasonography
Abstract

Introduction:  Contrast-enhanced ultrasound is utilized in an increasing array of medical fields, including thoracic medicine. However, the technique is still relatively new and only sporadically mentioned in current guidelines and recommendations. The aim of this systematic review is to provide a literature overview and to critically appraise the current clinical applications of contrast-enhanced thoracic ultrasound (CETUS)., Materials and Methods:  A systematic literature search using major electronic databases and in accordance with PRISMA guidelines was performed. Studies with a primary focus on CETUS of thoracic disorders compared to a standard reference test were included. The QUADAS-2 tool was used for quality assessment of the studies., Results:  The search identified 43 articles: 1 randomized controlled study, 6 non-randomized controlled studies, 16 non-randomized non-controlled studies, 5 case series, 10 single case reports, and 5 animal studies. The overall risk of bias was judged to be high. Diagnostic accuracy measurements of noninvasive applications of CETUS were only reported in a few studies and they were too dissimilar for meta-analysis. Six studies compared CETUS-guided versus ultrasound-guided transthoracic needle biopsy of thoracic masses. They individually reported a significant increase in diagnostic accuracy in favor of CETUS guidance but were too heterogeneous for meta-analysis., Conclusion:  The current literature on CETUS is overall heterogeneous with a few high evidence level studies, small study populations and a high risk of bias. CETUS-guided biopsy is the most frequent clinical application and increases diagnostic accuracy compared to ultrasound guidance by an average of 14.6 percentage points., Competing Interests: The authors declare that they have no conflict of interest., (Thieme. All rights reserved.)

Published
2022
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27. The AFSUMB Consensus Statements and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound using Sonazoid.

Author

Lee JY, Minami Y, Choi BI, Lee WJ, Chou YH, Jeong WK, Park MS, Kudo N, Lee MW, Kamata K, Iijima H, Kim SY, Numata K, Sugimoto K, Maruyama H, Sumino Y, Ogawa C, Kitano M, Joo I, Arita J, Liang JD, Lin HM, Nolsoe C, Gilja OH, and Kudo M

Abstract

The first edition of the guidelines for the use of ultrasound contrast agents was published in 2004, dealing with liver applications. The second edition of the guidelines in 2008 reflected changes in the available contrast agents and updated the guidelines for the liver, as well as implementing some nonliver applications. The third edition of the contrast-enhanced ultrasound (CEUS) guidelines was the joint World Federation for Ultrasound in Medicine and Biology-European Federation of Societies for Ultrasound in Medicine and Biology (WFUMB-EFSUMB) venture in conjunction with other regional US societies such as Asian Federation of Societies for Ultrasound in Medicine and Biology, resulting in a simultaneous duplicate on liver CEUS in the official journals of both WFUMB and EFSUMB in 2013. However, no guidelines were described mainly for Sonazoid due to limited clinical experience only in Japan and Korea. The new proposed consensus statements and recommendations provide general advice on the use of Sonazoid and are intended to create standard protocols for the use and administration of Sonazoid in hepatic and pancreatobiliary applications in Asian patients and to improve patient management.

Published
2020
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28. WFUMB position paper on the management incidental findings: adrenal incidentaloma.

Author

Dietrich CF, Correas JM, Dong Y, Nolsoe C, Westerway SC, and Jenssen C

Abstract

Focal lesions of the adrenal glands are incidentally detected in approximately 5% of cases by modern imaging techniques. Fewer than 5% of these adrenal incidentalomas are malignant and approximately 10% have endocrine activity. Reliable differentiation of malignant versus benign and hormonally active versus nonfunctional adrenal incidentalomas significantly influences therapeutic management and the outcome of affected individuals. Therefore, each adrenal incidentaloma should undergo a standardized diagnostic work-up to exclude malignancy and endocrine activity. This position statement of the World Federation of Ultrasound in Medicine and Biology (WFUMB) summarizes the available evidence on the management of adrenal incidentaloma and describes efficient management strategies with particular reference to the role of ultrasound techniques.

Published
2020
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29. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Short Version).

Author

Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D'Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, and Wijkstra H

Subjects
Adult, Contrast Media, Female, Humans, Image Enhancement, Liver diagnostic imaging, Liver Neoplasms, Male, Phospholipids, Sulfur Hexafluoride, Ultrasonography standards, Practice Guidelines as Topic
Abstract

The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications., Competing Interests: Fabrizio Calliada: Congress participation support, Toshiba, Guerbet, Bayer, Hitachi, MindrayVito Cantisani: Congress participation support, Toshiba, Guerbet, Bayer, Hitachi, MindrayDirk Clevert: Speaker honoraria for Siemens, Philips, Samsung Falk, Bracco; Advisory Board Member Siemens, Philips, Samsung, Bracco; Research grants, Siemens, Philips, Samsung, BraccoDavid Cosgrove: Speaker honoraria, Bracco, Toshiba, SuperSonic, BK Medical, Carestream; Advisory Board Member, Toshiba, Carestream; Research grant, Carestream; Congress participation support, Bracco, ToshibaAnnamarie Dagenello: Speaker honoraria, BraccoChristoph F Dietrich: Speaker honoraria, Bracco, Hitachi, GE, Mindray, Supersonic, Pentax, Olympus, Fuji, Covidien, Boston Scientific, AbbVie, MSD, Falk Foundation, Novartis, Roche; Advisory Board Member, Hitachi and Mindray; Research grant, Bracco, Hitachi, GE, Siemens, Mindray, SuperSonic; Congress participation support, IPSENOdd Helge Gilja: Speaker honoraria, GE Healthcare Takeda AS and Meda ASChristian Jenssen: Speaker honoraria, Bracco, Hitachi, Toshiba, Falk Foundation, Covidien; Research grant, NovartisNathalie Lassau: Speaker honoraria, Bracco, Toshiba; Congress participation support, Bracco, ToshibaEdward Leen: Research equipment support, Philips Healthcare & SuperSonic ImagingMaria Franca Meloni: Speaker honoraria, BraccoChristian Pállson Nolsøe: Speaker honoraria and congress participation support, GE Healthcare and NeovitalisMirko D’Onofrio: Speaker honoraria, Bracco, Siemens; Advisor Board Member, Bracco, Siemens, Congress participation support, BraccoFabio Piscaglia: Speaker honoraria Bracco, Bayer; Advisory Board Member, Bayer; Research support, EsaoteMaija Radzina: Speaker honoaria, Bayer, Covidien; Congress participation support, BayerAdrian Saftiou: Speaker honoraria, Pentax Medical Singapore Ltd; Consulting/Advisory board, Mediglobe Corporation Gmbh; Congress participation support, Hitachi Medical Systems UKPaul Sidhu: Speaker honoraria, Siemens, Bracco, Hitachi, Philips and GEHans-Peter Weskott: Speaker honoraria for Bracco, Samsung and GEThe following members declared no conflicts of interest: Eva Bartels, Michele Bertolotto, Francesca Drudi, Simon Freeman, Christopher Harvey, Ernst Michael Jung, Andrea Klauser, Carlos Nicolau, Francesco Prada, Luca Savelli, Hessel Wijkstra, (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2018
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30. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version).

Author

Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D'Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, and Wijkstra H

Subjects
Adult, Contrast Media, Female, Humans, Image Enhancement, Liver diagnostic imaging, Liver Neoplasms, Male, Phospholipids, Sulfur Hexafluoride, Ultrasonography standards, Practice Guidelines as Topic
Abstract

The updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications., Competing Interests: Fabrizio Calliada: Congress participation support, Toshiba, Guerbet, Bayer, Hitachi, MindrayVito Cantisani: Congress participation support, Toshiba, Guerbet, Bayer, Hitachi, MindrayDirk Clevert: Speaker honoraria for Siemens, Philips, Samsung Falk, Bracco; Advisory Board Member Siemens, Philips, Samsung, Bracco; Research grants, Siemens, Philips, Samsung, BraccoDavid Cosgrove: Speaker honoraria, Bracco, Toshiba, SuperSonic, BK Medical, Carestream; Advisory Board Member, Toshiba, Carestream; Research grant, Carestream; Congress participation support, Bracco, ToshibaAnnamarie Dagenello: Speaker honoraria, BraccoChristoph F Dietrich: Speaker honoraria, Bracco, Hitachi, GE, Mindray, Supersonic, Pentax, Olympus, Fuji, Covidien, Boston Scientific, AbbVie, MSD, Falk Foundation, Novartis, Roche; Advisory Board Member, Hitachi and Mindray; Research grant, Bracco, Hitachi, GE, Siemens, Mindray, SuperSonic; Congress participation support, IPSENOdd Helge Gilja: Speaker honoraria, GE Healthcare Takeda AS and Meda ASChristian Jenssen: Speaker honoraria, Bracco, Hitachi, Toshiba, Falk Foundation, Covidien; Research grant, NovartisNathalie Lassau: Speaker honoraria, Bracco, Toshiba; Congress participation support, Bracco, ToshibaEdward Leen: Research equipment support, Philips Healthcare & SuperSonic ImagingMaria Franca Meloni: Speaker honoraria, BraccoChristian Pállson Nolsøe: Speaker honoraria and congress participation support, GE Healthcare and NeovitalisMirko D’Onofrio: Speaker honoraria, Bracco, Siemens; Advisor Board Member, Bracco, Siemens, Congress participation support, BraccoFabio Piscaglia: Speaker honoraria Bracco, Bayer; Advisory Board Member, Bayer; Research support, EsaoteMaija Radzina: Speaker honoaria, Bayer, Covidien; Congress participation support, BayerAdrian Saftiou: Speaker honoraria, Pentax Medical Singapore Ltd; Consulting/Advisory board, Mediglobe Corporation Gmbh; Congress participation support, Hitachi Medical Systems UKPaul Sidhu: Speaker honoraria, Siemens, Bracco, Hitachi, Philips and GEHans-Peter Weskott: Speaker honoraria for Bracco, Samsung and GEThe following members declared no conflicts of interest: Eva Bartels, Michele Bertolotto, Francesca Drudi, Simon Freeman, Christopher Harvey, Ernst Michael Jung, Andrea Klauser, Carlos Nicolau, Francesco Prada, Luca Savelli, Hessel Wijkstra, (© Georg Thieme Verlag KG Stuttgart · New York.)

Published
2018
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