1. Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
- Author
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Capocchi JK, Figueroa-Romero C, Dunham SJB, Faraci G, Rothman JA, Whiteson KL, Seo DO, Holtzman DM, Grabrucker S, Nolan YM, Kaddurah-Daouk R, and Jett DA
- Subjects
- Humans, Animals, Brain-Gut Axis physiology, Dementia prevention & control, Dementia microbiology, Brain microbiology, Alzheimer Disease microbiology, Alzheimer Disease prevention & control, Alzheimer Disease therapy, Gastrointestinal Microbiome physiology
- Abstract
Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota-gut-brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD., Competing Interests: The authors declare no competing financial interests. R.K.-D. is an inventor on key patents in the metabolomics field and holds equity in Metabolon and Chymia., (Copyright © 2024 the authors.)
- Published
- 2024
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