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19 results on '"Noirat, Amandine"'

4. An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa

Author

Vesin, Benjamin, Lopez, Jodie, Noirat, Amandine, Authié, Pierre, Fert, Ingrid, Le Chevalier, Fabien, Moncoq, Fanny, Nemirov, Kirill, Blanc, Catherine, Planchais, Cyril, Mouquet, Hugo, Guinet, Françoise, Hardy, David, Vives, Francina Langa, Gerke, Christiane, Anna, François, Bourgine, Maryline, Majlessi, Laleh, and Charneau, Pierre

Published
2022
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6. Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

Author

Ku, Min-Wen, Bourgine, Maryline, Authié, Pierre, Lopez, Jodie, Nemirov, Kirill, Moncoq, Fanny, Noirat, Amandine, Vesin, Benjamin, Nevo, Fabien, Blanc, Catherine, Souque, Philippe, Tabbal, Houda, Simon, Emeline, Hardy, David, Le Dudal, Marine, Guinet, Françoise, Fiette, Laurence, Mouquet, Hugo, Anna, François, Martin, Annette, Escriou, Nicolas, Majlessi, Laleh, and Charneau, Pierre

Published
2021
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7. Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice

Author

Ku, Min‐Wen, Authié, Pierre, Bourgine, Maryline, Anna, François, Noirat, Amandine, Moncoq, Fanny, Vesin, Benjamin, Nevo, Fabien, Lopez, Jodie, Souque, Philippe, Blanc, Catherine, Fert, Ingrid, Chardenoux, Sébastien, Lafosse, llta, Cussigh, Delphine, Hardy, David, Nemirov, Kirill, Guinet, Françoise, Langa Vives, Francina, Majlessi, Laleh, and Charneau, Pierre

Published
2021
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8. Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine

Author

Douguet, Laëtitia, primary, Fert, Ingrid, additional, Lopez, Jodie, additional, Vesin, Benjamin, additional, Le Chevalier, Fabien, additional, Moncoq, Fanny, additional, Authié, Pierre, additional, Nguyen, Trang‐My, additional, Noirat, Amandine, additional, Névo, Fabien, additional, Blanc, Catherine, additional, Bourgine, Maryline, additional, Hardy, David, additional, Anna, François, additional, Majlessi, Laleh, additional, and Charneau, Pierre, additional

Published
2023
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10. Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters

Author

Vesin, Benjamin, primary, Authié, Pierre, additional, Blanc, Catherine, additional, Fert, Ingrid, additional, Noirat, Amandine, additional, Le Chevalier, Fabien, additional, Wei, Yu, additional, Ku, Min-Wen, additional, Nemirov, Kirill, additional, Anna, François, additional, Hardy, David, additional, Planchais, Cyril, additional, Mouquet, Hugo, additional, Guinet, Françoise, additional, Charneau, Pierre, additional, Majlessi, Laleh, additional, and Bourgine, Maryline, additional

Published
2022
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11. Mice Humanized for Major Histocompatibility Complex and Angiotensin-Converting Enzyme 2 with High Permissiveness to SARS-CoV-2 Omicron Replication

Author

Le Chevalier, Fabien, primary, Authie, Pierre, additional, Chardenoux, Sebastien, additional, Bourgine, Maryline, additional, Vesin, Benjamin, additional, Cussigh, Delphine, additional, Sassier, Yohann, additional, Fert, Ingrid, additional, Noirat, Amandine, additional, Nemirov, Kirill, additional, ANNA, Francois, additional, BERARD, Marion, additional, Guinet, Francoise, additional, Hardy, David, additional, Charneau, Pierre, additional, Lemonnier, Francois, additional, Langa-Vives, Francina, additional, and MAJLESSI, Laleh, additional

Published
2022
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12. An intranasal lentiviral booster broadens immune recognition of SARS-CoV-2 variants and reinforces the waning mRNA vaccine-induced immunity that it targets to lung mucosa

Author

Vesin, Benjamin, primary, Lopez, Jodie, additional, Noirat, Amandine, additional, Authié, Pierre, additional, Fert, Ingrid, additional, Le Chevalier, Fabien, additional, Moncoq, Fanny, additional, Nemirov, Kirill, additional, Blanc, Catherine, additional, Planchais, Cyril, additional, Mouquet, Hugo, additional, Guinet, Françoise, additional, Hardy, David, additional, Gerke, Christiane, additional, Anna, François, additional, Bourgine, Maryline, additional, MAJLESSI, Laleh, additional, and Charneau, Pierre, additional

Published
2022
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13. Full-Lung Prophylaxis against SARS-CoV-2 by One-Shot or Booster Intranasal Lentiviral Vaccination in Syrian Golden Hamsters.

Author

Vesin, Benjamin, Authié, Pierre, Blanc, Catherine, Fert, Ingrid, Noirat, Amandine, Le Chevalier, Fabien, Wei, Yu, Ku, Min-Wen, Nemirov, Kirill, Anna, François, Hardy, David, Planchais, Cyril, Mouquet, Hugo, Guinet, Françoise, Charneau, Pierre, Majlessi, Laleh, and Bourgine, Maryline

Subjects
SARS-CoV-2, SARS-CoV-2 Omicron variant, GOLDEN hamster, VACCINE effectiveness, BOOSTER vaccines
Abstract

Following the breakthrough of numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in recent months and the incomplete efficiency of the currently available vaccines, development of more effective vaccines is desirable. Non-integrative, non-cytopathic and non-inflammatory lentiviral vectors elicit sterilizing prophylaxis against SARS-CoV-2 in preclinical animal models and are particularly suitable for mucosal vaccination, which is acknowledged as the most effective in reducing viral transmission. Here, we demonstrate that a single intranasal administration of a vaccinal lentiviral vector encoding a stabilized form of the original SARS-CoV-2 Spike glycoprotein induces full-lung protection of respiratory tracts and strongly reduces pulmonary inflammation in the susceptible Syrian golden hamster model against the prototype SARS-CoV-2. In addition, we show that a lentiviral vector encoding stabilized Spike of SARS-CoV-2 Beta variant (LV::SBeta-2P) prevents pathology and reduces infectious viral loads in lungs and nasal turbinates following inoculation with the SARS-CoV-2 Omicron variant. Importantly, an intranasal boost with LV::SBeta-2P improves cross-seroneutralization much better in LV::SBeta-2P-primed hamsters than in their counterparts primed with an LV-encoding Spike from the ancestral SARS-CoV-2. These results strongly suggest that an immune imprint with the original Spike sequence has a negative impact on cross-protection against new variants. Our results tackle the issue of vaccine effectiveness in people who have already been vaccinated and have vanished immunity and indicate the efficiency of LV-based intranasal vaccination, either as a single dose or as booster. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Brain and Lung Cross-Protection against Ancestral or Emerging SARS-CoV-2 by Intranasal Lentiviral Vaccination in a New hACE2 Transgenic Murine Model

Author

Ku, Min-Wen, primary, Authié, Pierre, additional, Bourgine, Maryline, additional, Anna, François, additional, Noirat, Amandine, additional, Moncoq, Fanny, additional, Vesin, Benjamin, additional, Nevo, Fabien, additional, Lopez, Jodie, additional, Souque, Philippe, additional, Blanc, Catherine, additional, Fert, Ingrid, additional, Chardenoux, Sébastien, additional, Lafosse, llta, additional, Cussigh, Delphine, additional, Hardy, David, additional, Nemirov, Kirill, additional, Guinet, Françoise Guinet, additional, Vives, Francina Langa, additional, Majlessi, Laleh, additional, and Charneau, Pierre, additional

Published
2021
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15. Full Brain and Lung Prophylaxis against SARS-CoV-2 by Intranasal Lentiviral Vaccination in a New hACE2 Transgenic Mouse Model or Golden Hamsters

Author

Ku, Min-Wen, primary, Authié, Pierre, additional, Bourgine, Maryline, additional, Anna, François, additional, Noirat, Amandine, additional, Moncoq, Fanny, additional, Vesin, Benjamin, additional, Nevo, Fabien, additional, Lopez, Jodie, additional, Souque, Philippe, additional, Blanc, Catherine, additional, Chardenoux, Sébastien, additional, Lafosse, llta, additional, Hardy, David, additional, Nemirov, Kirill, additional, Guinet, Françoise, additional, Vives, Francina Langa, additional, Majlessi, Laleh, additional, and Charneau, Pierre, additional

Published
2021
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16. A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4+T-cell immunity

Author

Anna, François, Lopez, Jodie, Moncoq, Fanny, Blanc, Catherine, Authié, Pierre, Noirat, Amandine, Fert, Ingrid, Souque, Philippe, Nevo, Fabien, Pawlik, Alexandre, Hardy, David, Goyard, Sophie, Hudrisier, Denis, Brosch, Roland, Guinet, Françoise, Neyrolles, Olivier, Charneau, Pierre, and Majlessi, Laleh

Abstract

Most viral vectors, including the potently immunogenic lentiviral vectors (LVs), only poorly direct antigens to the MHC-II endosomal pathway and elicit CD4+T cells. We developed a new generation of LVs encoding antigen-bearing monomers of collectins substituted at their C-terminal domain with the CD40 ligand ectodomain to target and activate antigen-presenting cells. Host cells transduced with such optimized LVs secreted soluble collectin-antigen polymers with the potential to be endocytosed in vivo and reach the MHC-II pathway. In the murine tuberculosis model, such LVs induced efficient MHC-II antigenic presentation and triggered both CD8+and CD4+T cells at the systemic and mucosal levels. They also conferred a significant booster effect, consistent with the importance of CD4+T cells for protection against Mycobacterium tuberculosis. Given the pivotal role of CD4+T cells in orchestrating innate and adaptive immunity, this strategy could have a broad range of applications in the vaccinology field.

Published
2022
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18. Intranasal Vaccination with a Lentiviral Vector Strongly Protects against SARS-CoV-2 in Mouse and Golden Hamster Preclinical Models

Author

Ku, Min-Wen, primary, Bourgine, Maryline, additional, Authié, Pierre, additional, Lopez, Jodie, additional, Nemirov, Kirill, additional, Moncoq, Fanny, additional, Noirat, Amandine, additional, Vesin, Benjamin, additional, Nevo, Fabien, additional, Blanc, Catherine, additional, Souque, Philippe, additional, Tabbal, Houda, additional, Simon, Emeline, additional, Le Dudal, Marine, additional, Guinet, Françoise, additional, Fiette, Laurence, additional, Mouquet, Hugo, additional, Anna, François, additional, Martin, Annette, additional, Escriou, Nicolas, additional, Majlessi, Laleh, additional, and Charneau, Pierre, additional

Published
2020
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19. A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+T cell immunity

Author

Lopez, Jodie, Anna, François, Authié, Pierre, Pawlik, Alexandre, Ku, Min-Wen, Blanc, Catherine, Souque, Philippe, Moncoq, Fanny, Noirat, Amandine, Hardy, David, Sougakoff, Wladimir, Brosch, Roland, Guinet, Françoise, Charneau, Pierre, and Majlessi, Laleh

Abstract

Lentiviral vectors (LVs) are highly efficient at inducing CD8+T cell responses. However, LV-encoded antigens are processed inside the cytosol of antigen-presenting cells, which does not directly communicate with the endosomal major histocompatibility complex class II (MHC-II) presentation pathway. LVs are thus poor at inducing CD4+T cell response. To overcome this limitation, we devised a strategy whereby LV-encoded antigens are extended at their N-terminal end with the MHC-II-associated light invariant chain (li), which contains an endosome-targeting signal sequence. When evaluated with an LV-encoded polyantigen composed of CD4+T cell targets from Mycobacterium tuberculosis, intranasal vaccination in mice triggers pulmonary polyfunctional CD4+and CD8+T cell responses. Adjuvantation of these LVs extends the mucosal immunity to Th17 and Tc17 responses. A systemic prime and an intranasal boost with one of these LV induces protection against M. tuberculosis. This strategy improves the protective power of LVs against infections and cancers, where CD4+T cell immunity plays an important role.

Published
2022
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