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1. Factors that Affect the National Student Performance Examination Grades of Brazilian Undergraduate Medical Programs

Author

Neto, Toufic Anbar, da Silva Fucuta Pereia, Patricia, Nogueira, Mauricio L., Pereira de Gody, Jose Maria, and Moscardini, Airton C.

Subjects
independent medical assessment, medical school, medical education, Special aspects of education, LC8-6691, Medicine
Abstract

Background: The Brazilian National Student Performance Examination - ENADE is an instrument used to measure the quality of undergraduate courses. The identification of factors that influence the result of this examination can contribute to providing support necessary to improve the quality of medical courses. The purpose of this work was to evaluate the factors that affect the National Student Performance Examination grades of Brazilian undergraduate medical programs. Methods: Factors that influenced the 2010 ENADE grades of 100 undergraduate medical programs were studied. Data collection was performed using public databases. Academic and healthcare infrastructure variables were investigated. The data analysis was based on the performance of the medical programs on the 2010 ENADE, whereby the programs were divided into two groups: ENADE 1-2 (unsatisfactory grade) versus ENADE 4-5 (satisfactory grade). Results: One hundred schools were included in this analysis. In the univariate analysis the university variables (p=0.037), public institution (p

Published
2018
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3. Potential of Ilhéus virus to emerge

Author

Plante, Kenneth S., Plante, Jessica A., Azar, Sasha R., Shinde, Divya P., Scharton, Dionna, Versiani, Alice F., Oliveira da Silva, Natalia Ingrid, Strange, Taylor, Sacchetto, Lívia, Fokam, Eric B., Rossi, Shannan L., Weaver, Scott C., Marques, Rafael E., Nogueira, Mauricio L., and Vasilakis, Nikos

Published
2024
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4. EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil

Author

Collins, Matthew H., Potter, Gail E., Hitchings, Matt D. T., Butler, Ellie, Wiles, Michelle, Kennedy, Jessie K., Pinto, Sofia B., Teixeira, Adla B. M., Casanovas-Massana, Arnau, Rouphael, Nadine G., Deye, Gregory A., Simmons, Cameron P., Moreira, Luciano A., Nogueira, Mauricio L., Cummings, Derek A. T., Ko, Albert I., Teixeira, Mauro M., and Edupuganti, Srilatha

Published
2022
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5. Treatments for dengue: a Global Dengue Alliance to address unmet needs

Author

Anasir, Mohd Ishtiaq, primary, Angkasekwinai, Nasikarn, additional, Auewarakul, Prasert, additional, Avirutnan, Panisadee, additional, Bilbe, Graeme, additional, Charvillon, Fabienne Burgat, additional, Costa, Vivian Vasconcelos, additional, Croda, Julio, additional, Daher, Andre, additional, Das, Supratik, additional, Ellan, E.Kavithambigai, additional, Gani, Yasmin, additional, Garg, Pramod, additional, Uppal, Geetanjali, additional, Guruge, Dinuka, additional, Kalyanasundram, Jeevanathan, additional, Kratz, Jadel Müller, additional, Krieger, Marco A., additional, Lapphra, Keswadee, additional, Lim, Steven Chee Loon, additional, Lodha, Rakesh, additional, Mahajan, Dinesh, additional, Malavige, Gathsaurie Neelika, additional, Mairiang, Dumrong, additional, Marques, Ernesto Torres D Azevedo, additional, Md Jelas, Nur Hana, additional, Medigeshi, Guruprasad R., additional, Mohd Abd Razak, Mohd Ridzuan, additional, Mohd Zain, Rozainanee, additional, Mowbray, Charles, additional, Nischal, Neeraj, additional, Nogueira, Mauricio L., additional, Noisakran, Sansanee, additional, Punyadee, Nuntaya, additional, Pedrique, Belen, additional, Piedagnel, Jean-Michel, additional, Punnawit Phongpitchanont, Surat, additional, Ramanaidu, Tilakbabu, additional, Ribeiro, Isabela, additional, Rose, Winsley, additional, Rupali, Priscilla, additional, Samal, Sweety, additional, Singh, Kavita, additional, Siqueira, Andre M., additional, Sjö, Peter, additional, Sosa-Estani, Sergio, additional, Souza, Thiago Moreno L., additional, Suppiah, Jeyanthi, additional, Syed Mohamed, Ami Fazlin, additional, Mohd Tahir, Nur Zaidah, additional, Tan, Terence Yew Chin, additional, Teixeira, Mauro M., additional, Thayan, Ravindran, additional, Wadhwa, Nitya, additional, Wijewickrama, Ananda, additional, Mohamed Yusoff, Fazlina, additional, and Zainol, Murizal, additional

Published
2023
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6. Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil

Author

de Souza, William Marciel, Buss, Lewis Fletcher, Candido, Darlan da Silva, Carrera, Jean-Paul, Li, Sabrina, Zarebski, Alexander E., Pereira, Rafael Henrique Moraes, Prete, Jr, Carlos A., de Souza-Santos, Andreza Aruska, Parag, Kris V., Belotti, Maria Carolina T. D., Vincenti-Gonzalez, Maria F., Messina, Janey, da Silva Sales, Flavia Cristina, Andrade, Pamela dos Santos, Nascimento, Vítor Heloiz, Ghilardi, Fabio, Abade, Leandro, Gutierrez, Bernardo, Kraemer, Moritz U. G., Braga, Carlos K. V., Aguiar, Renato Santana, Alexander, Neal, Mayaud, Philippe, Brady, Oliver J., Marcilio, Izabel, Gouveia, Nelson, Li, Guangdi, Tami, Adriana, de Oliveira, Silvano Barbosa, Porto, Victor Bertollo Gomes, Ganem, Fabiana, de Almeida, Walquiria Aparecida Ferreira, Fantinato, Francieli Fontana Sutile Tardetti, Macário, Eduardo Marques, de Oliveira, Wanderson Kleber, Nogueira, Mauricio L., Pybus, Oliver G., Wu, Chieh-Hsi, Croda, Julio, Sabino, Ester C., and Faria, Nuno Rodrigues

Published
2020
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7. Zika Virus (Flaviviridae)

Author

Vasilakis, Nikos, primary, Rossi, Shannan L., additional, Azar, Sasha R., additional, Cisneros, Irma E., additional, Estofolete, Cassia F., additional, and Nogueira, Mauricio L., additional

Published
2021
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9. Field-deployable viral diagnostics using CRISPR-Cas13

Author

Myhrvold, Cameron, Freije, Catherine A., Gootenberg, Jonathan S., Abudayyeh, Omar O., Metsky, Hayden C., Durbin, Ann F., Kellner, Max J., Tan, Amanda L., Paul, Lauren M., Parham, Leda A., Garcia, Kimberly F., Barnes, Kayla G., Chak, Bridget, Mondini, Adriano, Nogueira, Mauricio L., Isern, Sharon, Michael, Scott F., Lorenzana, Ivette, Yozwiak, Nathan L., MacInnis, Bronwyn L., Bosch, Irene, Gehrke, Lee, Zhang, Feng, and Sabeti, Pardis C.

Published
2018

12. Essential role of the CCL2-CCR2 axis in Mayaro virus-induced disease

Author

Santos, Franciele Martins, primary, Melo, Victor Costa, additional, Araújo, Simone, additional, Sousa, Carla Daiane Ferreira, additional, Moreira, Thaiane Pinto, additional, Gonçalves, Mateus Rodrigues, additional, Santos, Anna CPM, additional, Seabra, Heloísa Athayde, additional, Costa, Pedro Augusto Carvalho, additional, Barrioni, Breno Rocha, additional, Souza, Paula Bargi, additional, Pereira, Marivalda de Magalhães, additional, Nogueira, Mauricio L., additional, Souza, Daniele G., additional, Guimarães, Pedro Pires, additional, Texeira, Mauro M, additional, Queiroz-Junior, Celso Martins, additional, and Costa, Vivian Vasconcelos, additional

Published
2023
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14. Performance of VIDAS® Diagnostic Tests for the Automated Detection of Dengue Virus NS1 Antigen and of Anti-Dengue Virus IgM and IgG Antibodies: A Multicentre, International Study

Author

Versiani, Alice F., primary, Kaboré, Antoinette, additional, Brossault, Ludovic, additional, Dromenq, Loïc, additional, dos Santos, Thayza M. I. L., additional, Milhim, Bruno H. G. A., additional, Estofolete, Cássia F., additional, Cissé, Assana, additional, Sorgho, Pegdwendé Abel, additional, Senot, Florence, additional, Tessonneau, Marie, additional, Diagbouga, Serge, additional, and Nogueira, Mauricio L., additional

Published
2023
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17. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum

Author

Bosch, Irene, de Puig, Helena, Hiley, Megan, Carré-Camps, Marc, Perdomo-Celis, Federico, Narváez, Carlos F., Salgado, Doris M., Senthoor, Dewahar, O’Grady, Madeline, Phillips, Elizabeth, Durbin, Ann, Fandos, Diana, Miyazaki, Hikaru, Yen, Chun-Wan, Gélvez-Ramírez, Margarita, Warke, Rajas V., Ribeiro, Lucas S., Teixeira, Mauro M., Almeida, Roque P., Muñóz-Medina, José E., Ludert, Juan E., Nogueira, Mauricio L., Colombo, Tatiana E., Terzian, Ana C. B., Bozza, Patricia T., Calheiros, Andrea S., Vieira, Yasmine R., Barbosa-Lima, Giselle, Vizzoni, Alexandre, Cerbino-Neto, José, Bozza, Fernando A., Souza, Thiago M. L., Trugilho, Monique R. O., de Filippis, Ana M. B., de Sequeira, Patricia C., Marques, Ernesto T. A., Magalhaes, Tereza, Díaz, Francisco J., Restrepo, Berta N., Marín, Katerine, Mattar, Salim, Olson, Daniel, Asturias, Edwin J., Lucera, Mark, Singla, Mohit, Medigeshi, Guruprasad R., de Bosch, Norma, Tam, Justina, Gómez-Márquez, Jose, Clavet, Charles, Villar, Luis, Hamad-Schifferli, Kimberly, and Gehrke, Lee

Published
2017
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19. Long-Term Viruria in Zika Virus-Infected Pregnant Women, Brazil, 2016

Author

Terzian, Ana Carolina B., Estofolete, Cassia Fernanda, Silva, Rafael Alves da, Vaz-Oliani, Denise Cristina Mos, Oliani, Antonio Helio, de Mattos, Cinara Cassia Brandao, de Mattos, Luiz Carlos, Rahal, Paula, and Nogueira, Mauricio L.

Subjects
Yellow fever -- Surveys, Zika virus -- Surveys, Infection -- Surveys, Pregnancy -- Surveys, Guillain-Barre syndrome -- Surveys, Pregnant women -- Surveys, RNA -- Surveys, Health
Abstract

Zika virus is a reemerging flavivirus that was first isolated in Uganda in 1947 during the course of a yellow fever virus survey (1). The virus remained at low transmission [...]

Published
2017
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21. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort

Author

Bosch, Irene, Reddy, Ankita, de Puig, Helena, Ludert, Juan E., Perdomo-Celis, Federico, Narváez, Carlos F., Versiani, Alice, Fandos, Diana, Nogueira, Mauricio L., Singla, Mohit, Lodha, Rakesh, Medigeshi, Guruprasad R., Lorenzana, Ivette, Ralde, Hugo Vicente, Gélvez-Ramírez, Margarita, Villar, Luis A., Hiley, Megan, Mendoza, Laura, Salcedo, Nol, Herrera, Bobby Brooke, Gehrke, Lee, Bosch, Irene, Reddy, Ankita, de Puig, Helena, Ludert, Juan E., Perdomo-Celis, Federico, Narváez, Carlos F., Versiani, Alice, Fandos, Diana, Nogueira, Mauricio L., Singla, Mohit, Lodha, Rakesh, Medigeshi, Guruprasad R., Lorenzana, Ivette, Ralde, Hugo Vicente, Gélvez-Ramírez, Margarita, Villar, Luis A., Hiley, Megan, Mendoza, Laura, Salcedo, Nol, Herrera, Bobby Brooke, and Gehrke, Lee

Abstract

© 2020 Bosch et al. Background Dengue virus (DENV) infections pose one of the largest global barriers to human health. The four serotypes (DENV 1–4) present different symptoms and influence immune response to subsequent DENV infections, rendering surveillance, risk assessments, and disease control particularly challenging. Early diagnosis and appropriate clinical management is critical and can be achieved by detecting DENV nonstructural protein 1 (NS1) in serum during the acute phase. However, few NS1-based tests have been developed that are capable of differentiat-ing DENV serotypes and none are currently commercially available. Methodology/Principle findings We developed an enzyme-linked immunosorbent assay (ELISA) to distinguish DENV-1-4 NS1 using serotype-specific pairs of monoclonal antibodies. A total of 1,046 antibodies were harvested from DENV-immunized mice and screened for antigen binding affinity. ELISA clinical performance was evaluated using 408 polymerase chain reaction-confirmed dengue samples obtained from patients in Brazil, Honduras, and India. The overall sensitiv-ity of the test for pan-DENV was 79.66% (325/408), and the sensitivities for DENV-1-4 sero-typing were 79.1% (38/48), 80.41% (78/97), 100% (45/45), and 79.6% (98/123), respectively. Specificity reached 94.07–100%. Significance Our study demonstrates a robust antibody screening strategy that enabled the development of a serotype NS1-based ELISA with maximized specific and sensitive antigen binding. This sensitive and specific assay also utilized the most expansive cohort to date, and of which about half are from Latin America, a geographic region severely underrepresented in previous similar studies. This ELISA test offers potential enhanced diagnostics during the acute phase of infection to help guide patient care and disease control. These results indicate that this ELISA is a promising aid in early DENV-1-4 diagnosis and surveillance in regions of endemicity in addition to offer conven

Published
2022

22. Performance of VIDAS ® Diagnostic Tests for the Automated Detection of Dengue Virus NS1 Antigen and of Anti-Dengue Virus IgM and IgG Antibodies: A Multicentre, International Study.

Author

Versiani, Alice F., Kaboré, Antoinette, Brossault, Ludovic, Dromenq, Loïc, dos Santos, Thayza M. I. L., Milhim, Bruno H. G. A., Estofolete, Cássia F., Cissé, Assana, Sorgho, Pegdwendé Abel, Senot, Florence, Tessonneau, Marie, Diagbouga, Serge, and Nogueira, Mauricio L.

Subjects
DENGUE hemorrhagic fever, DENGUE viruses, IMMUNOGLOBULIN G, DIAGNOSIS methods, IMMUNOGLOBULINS, ANTIGENS
Abstract

Dengue is a serious mosquito-transmitted disease caused by the dengue virus (DENV). Rapid and reliable diagnosis of DENV infection is urgently needed in dengue-endemic regions. We describe here the performance evaluation of the CE-marked VIDAS® dengue immunoassays developed for the automated detection of DENV NS1 antigen and anti-DENV IgM and IgG antibodies. A multicenter concordance study was conducted in 1296 patients from dengue-endemic regions in Asia, Latin America, and Africa. VIDAS® dengue results were compared to those of competitor enzyme-linked immunosorbent assays (ELISA). The VIDAS® dengue assays showed high precision (CV ≤ 10.7%) and limited cross-reactivity (≤15.4%) with other infections. VIDAS® DENGUE NS1 Ag showed high positive and negative percent agreement (92.8% PPA and 91.7% NPA) in acute patients within 0–5 days of symptom onset. VIDAS® Anti-DENGUE IgM and IgG showed a moderate-to-high concordance with ELISA (74.8% to 90.6%) in post-acute and recovery patients. PPA was further improved in combined VIDAS® NS1/IgM (96.4% in 0–5 days acute patients) and IgM/IgG (91.9% in post-acute patients) tests. Altogether, the VIDAS® dengue NS1, IgM, and IgG assays performed well, either alone or in combination, and should be suitable for the accurate diagnosis of DENV infection in dengue-endemic regions. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Predictors of death in COVID-19 vaccine breakthrough infections in Brazil

Author

Estofolete, Cassia Fernanda, primary, Fares, Gislaine Fusco, additional, Banho, Cecilia Artico, additional, Sacchetto, Livia, additional, Campos, Guilherme R.F., additional, Moraes, Marília M., additional, dos Santos, Thayza M.I.L., additional, da Silva, Gislaine C. Dutra, additional, Queiroz, Flavia, additional, Mendes, Lina de Moura, additional, Salomão, Maria Lúcia Machado, additional, Negri, Andreia Francesli, additional, Barcelos, Michela Dias, additional, and Nogueira, Mauricio L., additional

Published
2022
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24. Performance of VIDAS® Diagnostic Tests for the Automated Detection of Dengue Virus NS1 Antigen and of Anti-Dengue Virus IgM and IgG Antibodies: a Multicentre, International Study

Author

Versiani, Alice F., primary, Kaboré, Antoinette, additional, Brossault, Ludovic, additional, Dromenq, Loïc, additional, dos Santos, Thayza M.I.L., additional, Milhim, Bruno H.G.A., additional, Estofolete, Cássia F., additional, Cissé, Assana, additional, Sorgho, Abel C., additional, Senot, Florence, additional, Tessonneau, Marie, additional, Diagbouga, Serge, additional, and Nogueira, Mauricio L., additional

Published
2022
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25. Additional file 1 of EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil

Author

Collins, Matthew H., Potter, Gail E., Hitchings, Matt D. T., Butler, Ellie, Wiles, Michelle, Kennedy, Jessie K., Pinto, Sofia B., Teixeira, Adla B. M., Casanovas-Massana, Arnau, Rouphael, Nadine G., Deye, Gregory A., Simmons, Cameron P., Moreira, Luciano A., Nogueira, Mauricio L., Cummings, Derek A. T., Ko, Albert I., Teixeira, Mauro M., and Edupuganti, Srilatha

Abstract

Additional file 1. SPIRIT 2013 Checklist.

Published
2022
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29. SARS-CoV-2 genomic monitoring in the São Paulo State unveils new sublineages of the AY.43 strain

Author

Lima, Alex Ranieri J., primary, Ribeiro, Gabriela, additional, Viala, Vincent Louis, additional, Lima, Loyze Paola Oliveira, additional, Martins, Antonio Jorge, additional, Barros, Claudia, additional, Marqueze, Elaine, additional, Bernardino, Jardelina, additional, Moretti, Debora, additional, Rodrigues, Evandra Strazza, additional, Santos, Elaine Vieira, additional, Brassaloti, Ricardo Augusto, additional, Cassano, Raquel, additional, Mariani, Pilar, additional, Clemente, Luan Gaspar, additional, Assato, Patricia Akemi, additional, Costa, Felipe Allan, additional, Poleti, Mirele Daiana, additional, Lesbon, Jessika Cristina Chagas, additional, Mattos, Elisangela Chicaroni, additional, Banho, Cecilia Artico, additional, Sacchetto, Livia S, additional, Moraes, Marilia Mazzi, additional, Palmieri, Melissa, additional, Silva, Fabiana Erica, additional, Grotto, Rejane Tommasini, additional, Souza-Neto, Jayme A., additional, Giovanetti, Marta, additional, Alcantara, Luiz, additional, Nogueira, Mauricio L, additional, Fukumasu, Heidge, additional, Coutinho, Luiz Lehmann, additional, Kashima, Simone, additional, Neto, Raul Machado, additional, Covas, Dimas Tadeu, additional, Slavov, Svetoslav Nanev, additional, Elias, Maria Carolina, additional, and Sampaio, Sandra Coccuzzo, additional

Published
2021
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30. Genomic epidemiology reveals how restriction measures shaped the SARS-CoV-2 epidemic in Brazil

Author

Giovanetti, Marta, primary, Nanev Slavov, Svetoslav, additional, Fonseca, Vagner, additional, Wilkinson, Eduan, additional, Tegally, Houriiyah, additional, Patane, Jose, additional, Viala, Vincent Louis, additional, San, Emmanuel James, additional, Strazza Rodrigues, Evandra, additional, Vieira Santos, Elaine, additional, Aburjaile, Flavia, additional, Xavier, Joilson, additional, Fritsch, Hegger, additional, Ribeiro Adelino, Talita Emile, additional, Pereira, Felicidade, additional, Leal, Arabela, additional, Campos de Melo Iani, Felipe, additional, de Carvalho Pereira, Glauco, additional, Vazquez, Cynthia, additional, Mercedes Estigarribia Sanabria, Gladys, additional, Cristina de Oliveira, Elaine, additional, Demarchi, Luiz, additional, Croda, Julio, additional, Bezerra, Rafael Dos Santos, additional, Oliveira de Lima, Loyze Paola, additional, Martins, Antonio Jorge, additional, dos Santos Barros, Claudia Renata, additional, Marqueze, Elaine Cristina, additional, de Souza Todao Bernardino, Jardelina, additional, Botequio Moretti, Debora, additional, Brassaloti, Ricardo Augusto, additional, de Lello Rocha Campos Cassano, Raquel, additional, Drummond Sampaio Correa Mariani, Pilar, additional, Paulo Kitajima, Joao, additional, Santos, Bibiana, additional, Proto Siqueira, Rodrigo, additional, Cantarelli, Vlademir Vicente, additional, Tosta, Stephane, additional, Brandao Nardy, Vanessa, additional, Reboredo de Oliveira da Silva, Luciana, additional, Astete Gomez, Marcela Kelly, additional, Gomes Lima, Jaqueline, additional, Ribeiro, Adriana Aparecida, additional, Rocha Guimaraes, Natalia, additional, Takao Watanabe, Luiz, additional, Barbosa Da Silva, Luana, additional, da Silva Ferreira, Raquel, additional, F. da Penha, Mara Patricia, additional, Ortega, Maria Jose, additional, Gomez de la Fuente, Andrea, additional, Villalba, Shirley, additional, Torales, Juan, additional, Gamarra, Maria Liz, additional, Aquino, Carolina, additional, Martinez Figueredo, Gloria Patricia, additional, Santos Fava, Wellington, additional, Motta Castro, Ana Rita C., additional, Venturini, James, additional, do Vale Leone de Oliveira, Sandra Maria, additional, Cavalheiro Maymone Goncalves, Crhistinne, additional, do Carmo Debur Rossa, Maria, additional, Nardi Becker, Guilherme, additional, Marinho Presibella, Mayra, additional, Quallio Marques, Nelson, additional, Nastassja Riediger, Irina, additional, Raboni, Sonia, additional, Mattoso, Gabriela, additional, Cataneo, Allan D., additional, Zanluca, Camila, additional, Duarte dos Santos, Claudia N, additional, Akemi Assato, Patricia, additional, da Silva da Costa, Felipe Allan, additional, Poleti, Mirele Daiana, additional, Chagas Lesbon, Jessika Cristina, additional, Chicaroni Mattos, Elisangela, additional, Artico Banho, Cecilia, additional, Sacchetto, Livia S, additional, Mazzi Moraes, Marilia, additional, Tommasini Grotto, Rejane Maria, additional, Souza-Neto, Jayme A., additional, Nogueira, Mauricio L, additional, Fukumasu, Heidge, additional, Lehmann Coutinho, Luiz, additional, Tocantins Calado, Rodrigo, additional, Machado Neto, Raul, additional, Bispo de Filippis, Ana Maria, additional, Venancio da Cunha, Rivaldo, additional, Freitas, Carla, additional, Leonel Peterka, Cassio Roberto, additional, Rangel Fernandes, Cassia de Fatima, additional, Navegantes, Wildo, additional, do Carmo Said, Rodrigo Fabiano, additional, Almiron, Maria, additional, Campelo de A e Melo, Carlos F, additional, Lourenco, Jose, additional, de Oliveira, Tulio, additional, Holmes, Edward C, additional, Haddad, Ricardo, additional, Sampaio, Sandra Coccuzzo, additional, Elias, Maria Carolina, additional, Kashima, Simone, additional, Alcantara, Luiz Carlos Junior, additional, and Covas, Dimas Tadeu, additional

Published
2021
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31. Understanding the Potential Impact of Different Drug Properties on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission and Disease Burden: A Modelling Analysis

Author

Whittaker, Charles, primary, Watson, Oliver J, additional, Alvarez-Moreno, Carlos, additional, Angkasekwinai, Nasikarn, additional, Boonyasiri, Adhiratha, additional, Carlos Triana, Luis, additional, Chanda, Duncan, additional, Charoenpong, Lantharita, additional, Chayakulkeeree, Methee, additional, Cooke, Graham S, additional, Croda, Julio, additional, Cucunubá, Zulma M, additional, Djaafara, Bimandra A, additional, Estofolete, Cassia F, additional, Grillet, Maria Eugenia, additional, Faria, Nuno R, additional, Figueiredo Costa, Silvia, additional, Forero-Peña, David A, additional, Gibb, Diana M, additional, Gordon, Anthony C, additional, Hamers, Raph L, additional, Hamlet, Arran, additional, Irawany, Vera, additional, Jitmuang, Anupop, additional, Keurueangkul, Nukool, additional, Kimani, Teresia Njoki, additional, Lampo, Margarita, additional, Levin, Anna S, additional, Lopardo, Gustavo, additional, Mustafa, Rima, additional, Nayagam, Shevanthi, additional, Ngamprasertchai, Thundon, additional, Njeri, Ng’ang’a Irene Hannah, additional, Nogueira, Mauricio L, additional, Ortiz-Prado, Esteban, additional, Perroud, Mauricio W, additional, Phillips, Andrew N, additional, Promsin, Panuwat, additional, Qavi, Ambar, additional, Rodger, Alison J, additional, Sabino, Ester C, additional, Sangkaew, Sorawat, additional, Sari, Djayanti, additional, Sirijatuphat, Rujipas, additional, Sposito, Andrei C, additional, Srisangthong, Pratthana, additional, Thompson, Hayley A, additional, Udwadia, Zarir, additional, Valderrama-Beltrán, Sandra, additional, Winskill, Peter, additional, Ghani, Azra C, additional, Walker, Patrick G T, additional, and Hallett, Timothy B, additional

Published
2021
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33. Case Study of Two Post Vaccination SARS-CoV-2 Infections with P1 Variants in CoronaVac Vaccinees in Brazil

Author

Estofolete, Cassia F., primary, Banho, Cecilia A., additional, Campos, Guilherme R. F., additional, Marques, Beatriz de C., additional, Sacchetto, Livia, additional, Ullmann, Leila S., additional, Possebon, Fabio S., additional, Machado, Luana F., additional, Syrio, Juliana D., additional, Araújo Junior, João P., additional, Bittar, Cintia, additional, Rahal, Paula, additional, Lobo, Suzana M. A., additional, Ferreira, Helena Lage, additional, Vasilakis, Nikos, additional, and Nogueira, Mauricio L., additional

Published
2021
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34. Understanding the Potential Impact of Different Drug Properties On SARS-CoV-2 Transmission and Disease Burden: A Modelling Analysis

Author

Whittaker, Charles, primary, Watson, Oliver J., additional, Alvarez-Moreno, Carlos, additional, Angkasekwinai, Nasikarn, additional, Boonyasiri, Adhiratha, additional, Triana, Luis Carlos, additional, Chanda, Duncan, additional, Charoenpong, Lantharita, additional, Chayakulkeeree, Methee, additional, Cooke, Graham S., additional, Croda, Julio, additional, Cucunubá, Zulma M, additional, Djaafara, Bimandra A., additional, Estofolete, Cassia F., additional, Grillet, Maria Eugenia, additional, Faria, Nuno R., additional, Costa, Silvia Figueiredo, additional, Forero-Peña, David A., additional, Gibb, Diana M., additional, Gordon, Anthony C, additional, Hamers, Raph L., additional, Hamlet, Arran, additional, Irawany, Vera, additional, Jitmuang, Anupop, additional, Keurueangkul, Nukool, additional, Kimani, Teresia Njoki, additional, Lampo, Margarita, additional, Levin, Anna S., additional, Lopardo, Gustavo, additional, Mustafa, Rima, additional, Nayagam, Shevanthi, additional, Ngamprasertchai, Thundon, additional, Hannah Njeri, Ng’ang’a Irene, additional, Nogueira, Mauricio L., additional, Ortiz-Prado, Esteban, additional, Perroud, Mauricio W., additional, Phillips, Andrew N., additional, Promsin, Panuwat, additional, Qavi, Ambar, additional, Rodger, Alison J., additional, Sabino, Ester C., additional, Sangkaew, Sorawat, additional, Sari, Djayanti, additional, Sirijatuphat, Rujipas, additional, Sposito, Andrei C., additional, Srisangthong, Pratthana, additional, Thompson, Hayley A., additional, Udwadia, Zarir, additional, Valderrama-Beltrán, Sandra, additional, Winskill, Peter, additional, Ghani, Azra C., additional, Walker, Patrick G.T., additional, and Hallett, Timothy B., additional

Published
2021
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35. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort

Author

Bosch, Irene, Reddy, Ankita, de Puig, Helena, Ludert, Juan E, Perdomo-Celis, Federico, Narváez, Carlos F, Versiani, Alice, Fandos, Diana, Nogueira, Mauricio L, Singla, Mohit, Lodha, Rakesh, Medigeshi, Guruprasad R, Lorenzana, Ivette, Ralde, Hugo Vicente, Gélvez-Ramírez, Margarita, Villar, Luis A, Hiley, Megan, Mendoza, Laura, Salcedo, Nol, Herrera, Bobby Brooke, Gehrke, Lee, Bosch, Irene, Reddy, Ankita, de Puig, Helena, Ludert, Juan E, Perdomo-Celis, Federico, Narváez, Carlos F, Versiani, Alice, Fandos, Diana, Nogueira, Mauricio L, Singla, Mohit, Lodha, Rakesh, Medigeshi, Guruprasad R, Lorenzana, Ivette, Ralde, Hugo Vicente, Gélvez-Ramírez, Margarita, Villar, Luis A, Hiley, Megan, Mendoza, Laura, Salcedo, Nol, Herrera, Bobby Brooke, and Gehrke, Lee

Abstract

© 2020 Bosch et al. Background Dengue virus (DENV) infections pose one of the largest global barriers to human health. The four serotypes (DENV 1–4) present different symptoms and influence immune response to subsequent DENV infections, rendering surveillance, risk assessments, and disease control particularly challenging. Early diagnosis and appropriate clinical management is critical and can be achieved by detecting DENV nonstructural protein 1 (NS1) in serum during the acute phase. However, few NS1-based tests have been developed that are capable of differentiat-ing DENV serotypes and none are currently commercially available. Methodology/Principle findings We developed an enzyme-linked immunosorbent assay (ELISA) to distinguish DENV-1-4 NS1 using serotype-specific pairs of monoclonal antibodies. A total of 1,046 antibodies were harvested from DENV-immunized mice and screened for antigen binding affinity. ELISA clinical performance was evaluated using 408 polymerase chain reaction-confirmed dengue samples obtained from patients in Brazil, Honduras, and India. The overall sensitiv-ity of the test for pan-DENV was 79.66% (325/408), and the sensitivities for DENV-1-4 sero-typing were 79.1% (38/48), 80.41% (78/97), 100% (45/45), and 79.6% (98/123), respectively. Specificity reached 94.07–100%. Significance Our study demonstrates a robust antibody screening strategy that enabled the development of a serotype NS1-based ELISA with maximized specific and sensitive antigen binding. This sensitive and specific assay also utilized the most expansive cohort to date, and of which about half are from Latin America, a geographic region severely underrepresented in previous similar studies. This ELISA test offers potential enhanced diagnostics during the acute phase of infection to help guide patient care and disease control. These results indicate that this ELISA is a promising aid in early DENV-1-4 diagnosis and surveillance in regions of endemicity in addition to offer conven

Published
2021

37. Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study.

Author

Grenfell, Rafaella F. Q., Almeida, Nathalie B. F., Filgueiras, Priscilla S., Corsini, Camila A., Gomes, Sarah V. C., de Miranda, Daniel A. P., Lourenço, Adelina J., Martins-Filho, Olindo A., de Oliveira, Jaquelline G., Teixeira-Carvalho, Andrea, Campos, Guilherme R. F., Nogueira, Mauricio L., Alves, Pedro Augusto, Fernandes, Gabriel R., Castilho, Leda R., Lima, Tulio M., de Abreu, Daniel P. B., Alvim, Renata G. F., Silva, Thaís Bárbara de S., and Jeremias, Wander de J.

Subjects
SARS-CoV-2, COVID-19 vaccines, IMMUNE response, IMMUNIZATION of children, BOOSTER vaccines, SARS-CoV-2 Delta variant
Abstract

Background: Effective and safe vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical to controlling the COVID-19 pandemic and will remain the most important tool in limiting the spread of the virus long after the pandemic is over. Methods: We bring pioneering contributions on the maintenance of the immune response over a year on a real-life basis study in 1,587 individuals (18-90 yrs, median 39 yrs; 1,208 female/379 male) who underwent vaccination with two doses of CoronaVac and BNT162b2 booster after 6-months of primary protocol. Findings: Elevated levels of anti-spike IgG antibodies were detected after CoronaVac vaccination, which significantly decreased after 80 days and remained stable until the introduction of the booster dose. Heterologous booster restored antibody titers up to-1·7-fold, changing overall seropositivity to 96%. Titers of neutralising antibodies to the Omicron variant were lower in all timepoints than those against Delta variant. Individuals presenting neutralising antibodies against Omicron also presented the highest titers against Delta and anti-Spike IgG. Cellular immune response measurement pointed out a mixed immune profile with a robust release of chemokines, cytokines, and growth factors on the first month after CoronaVac vaccination followed by a gradual reduction over time and no increase after the booster dose. A stronger interaction between those mediators was noted over time. Prior exposure to the virus leaded to a more robust cellular immune response and a rise in antibody levels 60 days post CoronaVac than in individuals with no previous COVID-19. Both vaccines were safe and well tolerated among individuals. Interpretation: Our data approach the effectiveness of CoronaVac association with BNT162b2 from the clinical and biological perspectives, aspects that have important implications for informing decisions about vaccine boosters. Funding: Fiocruz, Brazil. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Field-deployable viral diagnostics using CRISPR-Cas13

Author

McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Department of Biological Engineering, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Myhrvold, Cameron, Freije, Catherine A., Gootenberg, Jonathan S, Abudayyeh, Omar O., Metsky, Hayden C., Durbin, Ann F, Kellner, Max J., Tan, Amanda L., Paul, Lauren M., Parham, Leda A., Garcia, Kimberly F., Barnes, Kayla G., Chak, Bridget, Mondini, Adriano, Nogueira, Mauricio L., Isern, Sharon, Michael, Scott F., Lorenzana, Ivette, Yozwiak, Nathan L., MacInnis, Bronwyn L., Bosch, Irene, Gehrke, Lee, Zhang, Feng, Sabeti, Pardis C., McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology. Department of Biological Engineering, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Myhrvold, Cameron, Freije, Catherine A., Gootenberg, Jonathan S, Abudayyeh, Omar O., Metsky, Hayden C., Durbin, Ann F, Kellner, Max J., Tan, Amanda L., Paul, Lauren M., Parham, Leda A., Garcia, Kimberly F., Barnes, Kayla G., Chak, Bridget, Mondini, Adriano, Nogueira, Mauricio L., Isern, Sharon, Michael, Scott F., Lorenzana, Ivette, Yozwiak, Nathan L., MacInnis, Bronwyn L., Bosch, Irene, Gehrke, Lee, Zhang, Feng, and Sabeti, Pardis C.

Abstract

Mitigating global infectious disease requires diagnostic tools that are sensitive, specific, and rapidly field deployable. In this study, we demonstrate that the Cas13-based SHERLOCK (specific high-sensitivity enzymatic reporter unlocking) platform can detect Zika virus (ZIKV) and dengue virus (DENV) in patient samples at concentrations as low as 1 copy per microliter. We developed HUDSON (heating unextracted diagnostic samples to obliterate nucleases), a protocol that pairs with SHERLOCK for viral detection directly from bodily fluids, enabling instrument-free DENV detection directly from patient samples in <2 hours. We further demonstrate that SHERLOCK can distinguish the four DENV serotypes, as well as region-specific strains of ZIKV from the 2015–2016 pandemic. Finally, we report the rapid (<1 week) design and testing of instrument-free assays to detect clinically relevant viral single-nucleotide polymorphisms., NIH (Grants AI-100190, 1R01-HG009761, 1R01-MH110049, and 1DP1-HL141201)

Published
2020

40. Understanding the Potential Role of Therapeutics in Preventing Deaths Due to COVID-19: A Modelling Analysis

Author

Whittaker, Charles, primary, Watson, Oliver J., additional, Alvarez-Moreno, Carlos, additional, Angkasekwinai, Nasikarn, additional, Boonyasiri, Adhiratha, additional, Carlos Triana, Luis, additional, Chanda, Duncan, additional, Charoenpong, Lantharita, additional, Chayakulkeeree, Methee, additional, Cooke, Graham S., additional, Croda, Julio, additional, Cucunubá, Zulma M., additional, Djaafara, Bimandra Adiputra, additional, Estofolete, Cassia F., additional, Grillet, Maria Eugenia, additional, Faria, Nuno R., additional, Costa, Silvia Figueiredo, additional, Forena-Pena, David A., additional, Gibb, Diana M., additional, Gordon, Anthony C., additional, Hamers, Raph L., additional, Hamlet, Arran T.P., additional, Irawany, Vera, additional, Jitmuang, Anupop, additional, Keurueangkul, Nukool, additional, Njoki Kimani, Teresia, additional, Lampo, Margarita, additional, Levin, Anna, additional, Lopardo, Gustavo, additional, Mustafa, Rima, additional, Nayagam, Shevanthi, additional, Ngamprasertchai, Thundon, additional, Hannah Njeri, Ng&apos;ang&apos;a Irene, additional, Nogueira, Mauricio L., additional, Ortiz-Prado, Esteban, additional, Perroud Jr., Mauricio W., additional, Phillips, Andrew N., additional, Promsin, Panuwat, additional, Qavi, Ambar, additional, Rodger, Alison J., additional, Sabino, Ester C., additional, Sangkaew, Sorawat, additional, Sari, Djayanti, additional, Sirijatuphat, Rujipas, additional, Sposito, Andrei C., additional, Srisangthong, Pratthana, additional, Thompson, Hayley A., additional, Udwadia, Zarir, additional, Valderrama-Beltrán, Sandra, additional, Winskill, Peter, additional, Ghani, Azra, additional, Walker, Patrick G.T., additional, and Hallett, Timothy B., additional

Published
2021
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41. Presentation of fatal stroke due to SARS‐CoV‐2 and dengue virus coinfection

Author

Estofolete, Cassia F., primary, Machado, Luana F., additional, Zini, Nathalia, additional, Luckemeyer, Graziela D., additional, Moraes, Marilia M., additional, dos Santos, Thaysa M. I. L., additional, dos Santos, Bárbara F., additional, Ruiz, Leonardo G. P., additional, Vasilakis, Nikos, additional, Lobo, Suzana M. A., additional, and Nogueira, Mauricio L., additional

Published
2020
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43. Validating and modeling the impact of high-frequency rapid antigen screening on COVID-19 spread and outcomes

Author

Nash, Beatrice, primary, Badea, Anthony, additional, Reddy, Ankita, additional, Bosch, Miguel, additional, Salcedo, Nol, additional, Gomez, Adam R., additional, Versiani, Alice, additional, Silva, Gislaine Celestino Dutra, additional, dos Santos, Thayza Maria Izabel Lopes, additional, Milhim, Bruno H. G. A., additional, Moraes, Marilia M, additional, Campos, Guilherme Rodrigues Fernandes, additional, Quieroz, Flávia, additional, Reis, Andreia Francesli Negri, additional, Nogueira, Mauricio L., additional, Naumova, Elena N., additional, Bosch, Irene, additional, and Herrera, Bobby Brooke, additional

Published
2020
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44. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort

Author

Bosch, Irene, primary, Reddy, Ankita, additional, de Puig, Helena, additional, Ludert, Juan E., additional, Perdomo-Celis, Federico, additional, Narváez, Carlos F., additional, Versiani, Alice, additional, Fandos, Diana, additional, Nogueira, Mauricio L., additional, Singla, Mohit, additional, Lodha, Rakesh, additional, Medigeshi, Guruprasad R., additional, Lorenzana, Ivette, additional, Ralde, Hugo Vicente, additional, Gélvez-Ramírez, Margarita, additional, Villar, Luis A., additional, Hiley, Megan, additional, Mendoza, Laura, additional, Salcedo, Nol, additional, Herrera, Bobby Brooke, additional, and Gehrke, Lee, additional

Published
2020
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45. Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019

Author

de Jesus, Jaqueline Goes, primary, Dutra, Karina Rocha, additional, Sales, Flavia Cristina da Silva, additional, Claro, Ingra Morales, additional, Terzian, Ana Carolina, additional, Candido, Darlan da Silva, additional, Hill, Sarah C, additional, Thézé, Julien, additional, Torres, Celeste, additional, D’Agostini, Tatiana Lang, additional, Felix, Alvina Clara, additional, Reis, Andreia F Negri, additional, Alcantara, Luiz Carlos Junior, additional, de Abreu, André L, additional, Croda, Júlio HR, additional, de Oliveira, Wanderson K, additional, de Filipis, Ana Maria Bispo, additional, Camis, Maria do Carmo Rodrigues dos Santos, additional, Romano, Camila Malta, additional, Loman, Nick J, additional, Pybus, Oliver G, additional, Sabino, Ester Cerdeira, additional, Nogueira, Mauricio L, additional, and Faria, Nuno Rodrigues, additional

Published
2020
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47. Trombofilia hereditária por mutações G1691A do fator V Leiden (heterozigota) e G20210A do FII protrombina (homozigota) em paciente com acidente vascular cerebral isquêmico

Author

Ruiz,Leonardo G. P., Oliveira,Maria Gabriela L., Ruiz,Adriana L. Z., Daher,Camila S., and Nogueira,Mauricio L.

Subjects
mutação, trombose venosa, venous thrombosis, mutation, trombofilia, thrombophilia
Abstract

Mutations related to Factor V Leiden (G1691A) and prothrombin (G20210A) are associated with a significantly increased risk of venous thromboembolism. The identification of a patient affected by episodes of venous thromboembolism and carrier of G1691A (heterozygous) and G20210A (homozygous) polymorphisms was determined by molecular tests [real-time polymerase chain reaction (PCR) methodology, Genexpert system] during attendance at the Base Hospital of São José do Rio Preto-SP, Brazil. RESUMO Mutações relacionadas com o fator V de Leiden (G1691A) e a protrombina (G20210A) estão associadas a um significativo aumento do risco de tromboembolismo venoso. Por meio da realização de exames moleculares [metodologia de reação em cadeia da polimerase (PCR) em tempo real, sistema Genexpert], em pacientes atendidos no Hospital de Base de São José do Rio Preto-SP, Brasil, foi determinada a identificação de uma paciente afetada por episódios de tromboembolismo venoso e portadora dos polimorfismos G1691A (heterozigota) e G20210A (homozigota).

Published
2018

48. Early identification of dengue virus lineage replacement in Brazil using portable genomic surveillance

Author

de Jesus, Jaqueline Goes, primary, Dutra, Karina Rocha, additional, da Silva Salles, Flavia Cristina, additional, Claro, Ingra Morales, additional, Terzian, Ana Carolina, additional, da Silva Candido, Darlan, additional, Hill, Sarah C., additional, Thézé, Julien, additional, D’Agostini, Tatiana Lang, additional, Felix, Alvina Clara, additional, Negri Reis, Andreia F., additional, Alcantara, Luiz Carlos Junior, additional, Abreu, André L., additional, Croda, Júlio H. R., additional, de Oliveira, Wanderson K., additional, de Filipis, Ana Maria Bispo, additional, dos Santos Camis, Maria do Carmo Rodrigues, additional, Romano, Camila Malta, additional, Loman, Nick J., additional, Pybus, Oliver G., additional, Sabino, Ester Cerdeira, additional, Nogueira, Mauricio L., additional, and Faria, Nuno Rodrigues, additional

Published
2019
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50. Presentation of fatal stroke due to SARS‐CoV‐2 and dengue virus coinfection.

Author

Estofolete, Cassia F., Machado, Luana F., Zini, Nathalia, Luckemeyer, Graziela D., Moraes, Marilia M., dos Santos, Thaysa M. I. L., dos Santos, Bárbara F., Ruiz, Leonardo G. P., Vasilakis, Nikos, Lobo, Suzana M. A., and Nogueira, Mauricio L.

Subjects
SARS-CoV-2, DENGUE viruses, MIXED infections, ARBOVIRUSES, DENGUE hemorrhagic fever, STROKE
Abstract

Herein, we report a case of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and dengue coinfection, presented as a fatal stroke in our hospital, in São José do Rio Preto, São Paulo State, a Brazilian city hyperendemic for dengue viruses and other arthropod‐borne viruses (arboviruses) and currently facing a surge of SARS‐CoV‐2 cases. This case is the first described in the literature and contributes to the better understanding of clinical presentations of two important diseases in a tropical setting. [ABSTRACT FROM AUTHOR]

Published
2021
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