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5. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Author

Bousquet, J., Hellings, P.W., Aberer, W., Agache, I., Akdis, C.A., Akdis, M., Alberti, M.R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I.J., Anto, J.M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B.A., Basagana, X., Bateman, E.D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E.H., Bergmann, K.C., Bennoor, K.S., Benson, M., Bertorello, L., Białoszewski, A.Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A.L., Bonini, M., Bonini, S., Bosnic-Anticevich, C.S., Bosse, I., Bouchard, J., Boulet, L.P., Bourret, R., Bousquet, P.J., Braido, F., Briedis, V., Brightling, C.E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M.T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M.A., Camargos, P.A.M., Camuzat, T., Canfora, G., Canonica, G.W., Cardona, V., Carlsen, K.H., Carreiro-Martins, P., Carriazo, A.M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A.M., Chavannes, N.H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciaravolo, M.M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A.C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R.M., Corti, F., Costa, E., Costa-Dominguez, M.C., Courbis, A.L., Cox, L., Crescenzo, M., Cruz, A.A., Custovic, A., Czarlewski, W., Dahlen, S.E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J.A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M.G., Douagui, H., Dray, G., Dubakiene, R., Durham, S.R., Du Toit, G., Dykewicz, M.S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W.J., Fonseca, J.A., Fontaine, J.F., Forti, S., Fuentes-Perez, J.M., Gálvez-Romero, J.L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C.Y., Garcia-Cruz, M.H., Gemicioğlu, B., Genova, S., George, C., Gereda, J.E., Gerth van Wijk, R., Gomez, R.M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N.A., Gutter, Z., Guzmán, M.A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J.O.'B., Huerta-Villalobos, Y.R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J.C., Jares, E.J., Jassem, E., Johnston, S.L., Joos, G., Jung, K.S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A.F., Karjalainen, J., Kardas, P., Keil, T., Keith, P.K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M.L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L.T.T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K.C., Louis, R., Lourenço, O., Luna-Pech, J.A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R., Maspero, J.F., Mathieu-Dupas, E., Matta Campos, J.J., Matos, A.L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M.A., Melén, E., Melo-Gomes, E., Meltzer, E.O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M.D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F.F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T.D., O'Hehir, R.E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G.L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N.G., Park, H.S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J.L., Pereira, A.M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Potter, P., Pozzi, A.C., Price, D., Prokopakis, E.P., Puy, R., Pugin, B., Pulido Ross, R.E., Przemecka, M., Rabe, K.F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R.E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Schunemann, H.J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F.S., Shamai, S., Sheikh, A., Sierra, M., Simons, F.E.R., Siroux, V., Sisul, J.C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J.N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P.V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M.T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M.T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D.Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D.M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B.P., Yiallouros, P.K., Yorgancioglu, A., Yusuf, O.M., Zar, H.J., Zhang, L., Zhong, N., Zernotti, M.E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thomas, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-François, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlos, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T.T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlos, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnus, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zuberbier, Torsten

Published
2019
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8. Finite-size versus Surface effects in nanoparticles

Author

Kachkachi, H., Nogues, M., Tronc, E., and Garanin, D. A.

Subjects
Condensed Matter - Materials Science
Abstract

We study the finite-size and surface effects on the thermal and spatial behaviors of the magnetisation of a small magnetic particle. We consider two systems: 1) A box-shaped isotropic particle of simple cubic structure with either periodic or free boundary conditions. This case is treated analytically using the isotropic model of D-component spin vectors in the limit $D\to \infty$, including the magnetic field. 2) A more realistic particle ($\gamma $-Fe$_{2}$O$_{3}$) of ellipsoidal (or spherical) shape with open boundaries. The magnetic state in this particle is described by the anisotropic classical Dirac-Heisenberg model including exchange and dipolar interactions, and bulk and surface anisotropy. This case is dealt with by the classical Monte Carlo technique. It is shown that in both systems finite-size effects yield a positive contribution to the magnetisation while surface effects render a larger and negative contribution, leading to a net decrease of the magnetisation of the small particle with respect to the bulk system. In the system 2) the difference between the two contributions is enhanced by surface anisotropy. The latter also leads to non saturation of the magnetisation at low temperatures, showing that the magnetic order in the core of the particle is perturbed by the magnetic disorder on the surface. This is confirmed by the profile of the magnetisation., Comment: 6 pages of RevTex including 4 Figures, invited paper to 3rd EuroConference on Magnetic Properties of Fine Nanoparticles, Barcelona, October 99

Published
1999
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9. Surface effects in nanoparticles: application to maghemite $\gamma$-Fe_{2}O_{3}

Author

Kachkachi, H., Ezzir, A., Nogues, M., and Tronc, E.

Subjects
Condensed Matter - Materials Science
Abstract

We present a microscopic model for nanoparticles, of the maghemite ($\gamma $% -Fe$_{2}$O$_{3}$) type, and perform classical Monte Carlo simulations of their magnetic properties. On account of M\"{o}ssbauer spectroscopy and high-field magnetisation results, we consider a particle as composed of a core and a surface shell of constant thickness. The magnetic state in the particle is described by the anisotropic classical Dirac-Heisenberg model including exchange and dipolar interactions and bulk and surface anisotropy. We consider the case of ellipsoidal (or spherical) particles with free boundaries at the surface. Using a surface shell of constant thickness ($\sim 0.35$ nm) we vary the particle size and study the effect of surface magnetic disorder on the thermal and spatial behaviors of the net magnetisation of the particle. We study the shift in the surface ``critical region'' for different surface-to-core ratios of the exchange coupling constants. It is also shown that the profile of the local magnetisation exhibits strong temperature dependence, and that surface anisotropy is reponsible for the non saturation of the magnetisation at low temperatures., Comment: 15 pages, 7 figures, to appear in Eur. Phys. J. B

Published
1999
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10. Field dependence of the temperature at the peak of the ZFC magnetization

Author

Kachkachi, H., Coffey, W. T., Crothers, D. S. F., Ezzir, A., Kennedy, E. C., Nogues, M., and Tronc, E.

Subjects
Condensed Matter
Abstract

The effect of an applied magnetic field on the temperature at the maximum of the ZFC magnetization, $M_{ZFC}$, is studied using the recently obtained analytic results of Coffey et al. (Phys. Rev. Lett. {\bf 80}(1998) 5655) for the prefactor of the N\'{e}el relaxation time which allow one to precisely calculate the prefactor in the N\'{e}el-Brown model and thus the blocking temperature as a function of the coefficients of the Taylor series expansion of the magnetocrystalline anisotropy. The present calculations indicate that even a precise determination of the prefactor in the N\'{e}el-Brown theory, which always predicts a monotonic decrease of the relaxation time with increasing field, is insufficient to explain the effect of an applied magnetic field on the temperature at the maximum of the ZFC magnetization. On the other hand, we find that the non linear field-dependence of the magnetization along with the magnetocrystalline anisotropy appears to be of crucial importance to the existence of this maximum., Comment: 14 LaTex209 pages, 6 EPS figures. To appear in J. Phys.: Condensed Matter

Published
1999
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11. Polyamines in Human Milk and Their Benefits for Infant Health

Author

C., Muñoz-Esparza, Nelly, Oriol, Comas-Basté, M., Vásquez-Garibay, Edgar, Teresa, Veciana-Nogués, M., Luz, Latorre-Moratalla, M., and Carmen, Vidal-Carou, M.

Abstract

Breastfeeding is the gold standard for infant nutrition in the first six months of life when feeding choices determine growth and development. However, human milk is a complex and highly variable fluid that, in addition to nutrients, contains several bioactive components, including polyamines (putrescine, spermidine, and spermine), and constitutes the first exogenous source of these compounds for infants. Active in various cellular processes, polyamines are involved in the growth and maturation of the gastrointestinal tract and the development of the immune system and therefore play an important role in the first year of life. This chapter reviews the impact of polyamines on infant growth and health, the polyamine content in human milk and how it is influenced by factors related to both the mother-child dyad and breastfeeding itself. In addition, a comparative analysis of human milk and infant formulas in terms of polyamine content and profile is presented.

Published
2023

16. A Paper in Health Sciences: The Student Mentor

Author

Romeu, Marta, Taltavull, Núria, Moragas, Carlota M, Valls, Rosa M, Ribé, Mireia, Tarro, Lucía, Farré, Jordi, Albina, M Luisa, Casajuana, M del Carme, Arija, Victoria, Solà, Rosa, Nogués, M Rosa, and Giralt, Montserrat

Published
2015
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35. Targeting Oxidative Stress in Brain Aging. Effects of Increasing DHA Intake

Author

Moreno Acea, Francisco Javier, Méndez, Lucía, Lois, Salomé, Miralles-Pérez, Bernat, Romeu, Marta, Nogués, M. R., Ramos-Romero, Sara, Torres, Josep Lluís, Medina, Isabel, and Ministerio de Ciencia, Innovación y Universidades (España)

Subjects
lipids (amino acids, peptides, and proteins), social sciences, humanities, health care economics and organizations
Abstract

18th Euro Fed Lipid Congress and Expo: Fats, Oils and Lipids for a Healthy and Sustainable World, 18-21 October 2021, online, In the aging brain or in neurodegenerative disorders, the pronounced depletion of DHA-enriched phospholipids may indicate a persistent oxidative catabolic degradation, unmatched by a proper reacylation of the PUFAs. Brain tissue is particularly vulnerable to oxidative damage, because of the high consumption of oxygen, the easily peroxidizable high content of PUFAs in neuronal membranes, the low rate of cell turnover, and the high production of reactive oxygen and nitrogen species. Additionally, it is less endowed with a robust and diverse enzymatic and nonenzymatic antioxidant arsenal. In previous research, we have demonstrated a positive effect of fish oils on oxidative stress and inflammation associated to high caloric intake in animal models. The effect was largely dependent on the EPA/DHA ratios and closely related with an activation of the endogenous antioxidant system. As a consequence, lipids and proteins of plasma and target organs and tissues resulted specifically protected. On these basis, the present work aims to study the effect of increasing intake of DHA on the modulation of the lipid composition of brain cortex and the oxidative stress occurring in adult rats. Cerebral cortex plays a key role in memory, attention, perception, cognition and serve a wide range of neurologic functions. For that, an animal model of adult Wistar rats fed with standard diets supplemented with increasing DHA levels was used. Epilipidomics and lipidomics were applied to brain cortex and results were correlated with the endogenous antioxidant system. Results evidenced a modification of the lipid class pattern highly dependent of the PUFA intake. Interestingly, phrenosin (α-hydroxy GalCer) and phosphatidylethanolamine were found decreased while the levels of phosphatidylcholine were significantly increased. Supplementation with fish oils resulted in an enhancement of more than 2% of DHA in cortex lipids. The study of the specific oxidation products reveals a significant protection of cortex lipids in animals fed a high percent of DHA. It was noteworthy the specific protection found in oxidised phospholipids as phosphatidylcholine. Results were correlated with the enzymatic antioxidant content and the systemic level of oxidative stress detected in plasma and other tissues. To sum up, the regulation of lipid composition and oxidative stress in brain cortex associated to increasing DHA intake appears to have a pivotal role in both the healthy brain aging and the design of targeted-strategies., This work was supported by the Spanish Ministry of Science and Innovation (grant RTI2018-095659-B-I00)

Published
2021

45. Crosstalk between Natural Antioxidants and Omega 3 against oxidative stress in diet induced prediabetes

Author

Méndez, Lucía, Dasilva, Gabriel, Lois, Salomé, González, M. Jesús, Barros, Lorena, Miralles-Pérez, Bernat, Nogués, M. R., Ramos-Romero, Sara, Torres, Josep Lluís, and Medina, Isabel

Subjects
education, lipids (amino acids, peptides, and proteins), reproductive and urinary physiology, humanities, health care economics and organizations
Abstract

3rd International Symposium on Lipid Oxidation and Antioxidants, 23-24 November 2020, online

Published
2020

46. Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats

Author

Ministerio de Economía y Competitividad (España), Taltavull, Núria, Miralles-Pérez, Bernat, Nogués, M. R., Ramos-Romero, Sara, Méndez, Lucía, Medina, Isabel, Torres, Josep Lluís, Romeu, Marta, Ministerio de Economía y Competitividad (España), Taltavull, Núria, Miralles-Pérez, Bernat, Nogués, M. R., Ramos-Romero, Sara, Méndez, Lucía, Medina, Isabel, Torres, Josep Lluís, and Romeu, Marta

Abstract

Diacylglycerols (DAG) and ceramides have been suggested as early predictors of insulin resistance. This study was aimed to examine the combined effects of fish oil (FO) and grape seed extract (GSE) on hepatic endogenous antioxidants, DAG and ceramides in diet-induced early stages of insulin resistance. Thirty-five rats were fed one of the following diets: (1) a standard diet (STD group), (2) a high-fat high-sucrose diet (HFHS group), (3) an HFHS diet enriched with FO (FO group), (4) an HFHS diet enriched with GSE (GSE group) or (5) an HFHS diet enriched with FO and GSE (FO + GSE group). In the liver, endogenous antioxidants were measured using spectrophotometric and fluorometric techniques, and non-targeted lipidomics was conducted for the assessment of DAG and ceramides. After 24 weeks, the FO + GSE group showed increased glutathione peroxidase activity, as well as monounsaturated fatty acid and polyunsaturated fatty acid-containing DAG, and long-chain fatty acid-containing ceramides abundances compared to the STD group. The FO and GSE combination induced similar activation of the antioxidant system and bioactive lipid accumulation in the liver than the HFHS diet without supplementation. In addition, the FO and GSE combination increased the abundances of polyunsaturated fatty acid-containing DAG in the liver.

Published
2020

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