928 results on '"Nogué, Fabien"'
Search Results
2. Can genome editing help transitioning to agroecology?
- Author
-
Nogué, Fabien, Causse, Mathilde, Debaeke, Philippe, Déjardin, Annabelle, Lemarié, Stéphane, Richard, Guy, Rogowsky, Peter, and Caranta, Carole
- Published
- 2024
- Full Text
- View/download PDF
3. Blueprint for non-transgenic edited plants
- Author
-
Gallois, Jean-Luc and Nogué, Fabien
- Published
- 2023
- Full Text
- View/download PDF
4. Genome-wide specificity of plant genome editing by both CRISPR–Cas9 and TALEN
- Author
-
Bessoltane, Nadia, Charlot, Florence, Guyon-Debast, Anouchka, Charif, Delphine, Mara, Kostlend, Collonnier, Cécile, Perroud, Pierre-François, Tepfer, Mark, and Nogué, Fabien
- Published
- 2022
- Full Text
- View/download PDF
5. Assessment of genetically modified maize MON 95275 (application GMFF‐2022‐5890).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Naegeli, Hanspeter, Moreno, Francisco Javier, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Silvia, Federici, and Dumont, Antonio Fernandez
- Subjects
ANIMAL health ,CORN ,FOOD consumption ,GENETIC engineering ,ENVIRONMENTAL monitoring - Abstract
Genetically modified maize MON 95275 was developed to confer protection to certain coleopteran species. These properties were achieved by introducing the mpp75Aa1.1, vpb4Da2 and DvSnf7 expression cassettes. The molecular characterisation data and bioinformatic analyses reveal similarity to known toxins, which was further assessed. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize MON 95275 and its conventional counterpart needs further assessment. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Mpp75Aa1.1 and Vpb4Da2 proteins and the DvSnf7 dsRNA and derived siRNAs as expressed in maize MON 95275 and finds no evidence that the genetic modification would change the overall allergenicity of maize MON 95275. In the context of this application, the consumption of food and feed from maize MON 95275 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize MON 95275 is as safe as the conventional counterpart and non‐GM maize varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of maize MON 95275 material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 95275. The GMO Panel concludes that maize MON 95275 is as safe as its conventional counterpart and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Assessment of genetically modified maize DP910521 (application GMFF‐2021‐2473).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Naegeli, Hanspeter, Moreno, Francisco Javier, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Dumont, Antonio Fernandez, and Gennaro, Andrea
- Subjects
ANIMAL health ,CORN ,FOOD consumption ,ENVIRONMENTAL security ,INSECT pests - Abstract
Genetically modified (GM) maize DP910521 was developed to confer resistance against certain lepidopteran insect pests as well as tolerance to glufosinate herbicide; these properties were achieved by introducing the mo‐pat, pmi and cry1B.34 expression cassettes. The molecular characterisation data and bioinformatic analyses did not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP910521 and its conventional counterpart needs further assessment except for the levels of iron in grain, which do not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Cry1B.34, PAT and PMI proteins as expressed in maize DP910521. The GMO panel finds no evidence that the genetic modification impacts the overall safety of maize DP910521. In the context of this application, the consumption of food and feed from maize DP910521 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and non‐GM maize varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of maize DP910521 material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP910521. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Multiplex CRISPR-Cas9 mutagenesis of the phytochrome gene family in Physcomitrium (Physcomitrella) patens
- Author
-
Trogu, Silvia, Ermert, Anna Lena, Stahl, Fabian, Nogué, Fabien, Gans, Tanja, and Hughes, Jon
- Published
- 2021
- Full Text
- View/download PDF
8. The Physcomitrella patens gene atlas project: large‐scale RNA‐seq based expression data
- Author
-
Perroud, Pierre‐François, Haas, Fabian B, Hiss, Manuel, Ullrich, Kristian K, Alboresi, Alessandro, Amirebrahimi, Mojgan, Barry, Kerrie, Bassi, Roberto, Bonhomme, Sandrine, Chen, Haodong, Coates, Juliet C, Fujita, Tomomichi, Guyon‐Debast, Anouchka, Lang, Daniel, Lin, Junyan, Lipzen, Anna, Nogué, Fabien, Oliver, Melvin J, de León, Inés Ponce, Quatrano, Ralph S, Rameau, Catherine, Reiss, Bernd, Reski, Ralf, Ricca, Mariana, Saidi, Younousse, Sun, Ning, Szövényi, Péter, Sreedasyam, Avinash, Grimwood, Jane, Stacey, Gary, Schmutz, Jeremy, and Rensing, Stefan A
- Subjects
Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Biotechnology ,Human Genome ,1.1 Normal biological development and functioning ,Bryopsida ,Chromosome Mapping ,Datasets as Topic ,Genes ,Plant ,Genome ,Plant ,High-Throughput Nucleotide Sequencing ,Transcriptome ,developmental stage ,differential expression ,Physcomitrella patens ,RNA-seq ,stress ,transcriptome analysis ,Biochemistry and Cell Biology ,Plant Biology ,Plant Biology & Botany ,Biochemistry and cell biology ,Plant biology - Abstract
High-throughput RNA sequencing (RNA-seq) has recently become the method of choice to define and analyze transcriptomes. For the model moss Physcomitrella patens, although this method has been used to help analyze specific perturbations, no overall reference dataset has yet been established. In the framework of the Gene Atlas project, the Joint Genome Institute selected P. patens as a flagship genome, opening the way to generate the first comprehensive transcriptome dataset for this moss. The first round of sequencing described here is composed of 99 independent libraries spanning 34 different developmental stages and conditions. Upon dataset quality control and processing through read mapping, 28 509 of the 34 361 v3.3 gene models (83%) were detected to be expressed across the samples. Differentially expressed genes (DEGs) were calculated across the dataset to permit perturbation comparisons between conditions. The analysis of the three most distinct and abundant P. patens growth stages - protonema, gametophore and sporophyte - allowed us to define both general transcriptional patterns and stage-specific transcripts. As an example of variation of physico-chemical growth conditions, we detail here the impact of ammonium supplementation under standard growth conditions on the protonemal transcriptome. Finally, the cooperative nature of this project allowed us to analyze inter-laboratory variation, as 13 different laboratories around the world provided samples. We compare differences in the replication of experiments in a single laboratory and between different laboratories.
- Published
- 2018
9. Gene Drive-Modified Organisms: Developing Practical Risk Assessment Guidance
- Author
-
Devos, Yann, Bonsall, Michael B., Firbank, Leslie G., Mumford, John, Nogué, Fabien, and Wimmer, Ernst A.
- Published
- 2021
- Full Text
- View/download PDF
10. Physcomitrium patens Protoplasting and Protoplast Transfection
- Author
-
Charlot, Florence, primary, Goudounet, Guillaume, additional, Nogué, Fabien, additional, and Perroud, Pierre-François, additional
- Published
- 2022
- Full Text
- View/download PDF
11. HAG1 and SWI3A/B control of male germ line development in P. patens suggests conservation of epigenetic reproductive control across land plants
- Author
-
Genau, Anne C., Li, Zhanghai, Renzaglia, Karen S., Fernandez Pozo, Noe, Nogué, Fabien, Haas, Fabian B., Wilhelmsson, Per K. I., Ullrich, Kristian K., Schreiber, Mona, Meyberg, Rabea, Grosche, Christopher, and Rensing, Stefan A.
- Published
- 2021
- Full Text
- View/download PDF
12. Molecular biology of mosses
- Author
-
Fujita, Tomomichi, Nogué, Fabien, Rensing, Stefan A., Takezawa, Daisuke, and Vidali, Luis
- Published
- 2021
- Full Text
- View/download PDF
13. New developments in biotechnology applied to microorganisms.
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Cocconcelli, Pier Sandro, Glandorf, Debora, Herman, Lieve, Jimenez Saiz, Rodrigo, and Ruiz Garcia, Lorena
- Subjects
MICROBIAL biotechnology ,PHENOTYPIC plasticity ,PLACE marketing ,MUTAGENESIS ,GENOTYPES - Abstract
EFSA was requested by the European Commission (in accordance with Article 29 of Regulation (EC) No 178/2002) to provide a scientific opinion on the application of new developments in biotechnology (new genomic techniques, NGTs) to viable microorganisms and products of category 4 to be released into the environment or placed on the market as or in food and feed, and to non‐viable products of category 3 to be placed on the market as or in food and feed. A horizon scanning exercise identified a variety of products containing microorganisms obtained with NGTs (NGT‐Ms), falling within the remit of EFSA, that are expected to be placed on the (EU) market in the next 10 years. No novel potential hazards/risks from NGT‐Ms were identified as compared to those obtained by established genomic techniques (EGTs), or by conventional mutagenesis. Due to the higher efficiency, specificity and predictability of NGTs, the hazards related to the changes in the genome are likely to be less frequent in NGT‐Ms than those modified by EGTs and conventional mutagenesis. It is concluded that EFSA guidances are 'partially applicable', therefore on a case‐by‐case basis for specific NGT‐Ms, fewer requirements may be needed. Some of the EFSA guidances are 'not sufficient' and updates are recommended. Because possible hazards relate to genotypic and phenotypic changes introduced and not to the method used for the modification, it is recommended that any new guidance should take a consistent risk assessment approach for strains/products derived from or produced with microorganisms obtained with conventional mutagenesis, EGTs or NGTs. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. Scientific opinion on the ANSES analysis of Annex I of the EC proposal COM (2023) 411 (EFSA‐Q‐2024‐00178).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sanchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Casacuberta, Josep, Afonso, Ana, Lenzi, Paolo, and Papadopoulou, Nikoletta
- Subjects
TRANSGENIC plants ,INDUSTRIAL hygiene ,SCIENTIFIC literature ,SENTIMENT analysis ,TRANSGENIC organisms - Abstract
EFSA was asked by the European Parliament to provide a scientific opinion on the analysis by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) of Annex I of the European Commission proposal for a regulation 'on plants obtained by certain new genomic techniques (NGTs) and their food and feed, and amending regulation (EU) 2017/625'. The Panel on genetically modified organisms (GMO) assessed the opinion published by ANSES, which focuses on (i) the need to clarify the definitions and scope, (ii) the scientific basis for the equivalence criteria and (iii) the need to take potential risks from category 1 NGT plants into account. The EFSA GMO Panel considered the ANSES analysis and comments on various terms used in the criteria in Annex I of the European Commission proposal and discussed definitions based on previous EFSA GMO Panel opinions. The EFSA GMO Panel concluded that the available scientific literature shows that plants containing the types and numbers of genetic modifications used as criteria to identify category 1 NGT plants in the European Commission proposal do exist as the result of spontaneous mutations or random mutagenesis. Therefore, it is scientifically justified to consider category 1 NGT plants as equivalent to conventionally bred plants with respect to the similarity of genetic modifications and the similarity of potential risks. The EFSA GMO Panel did not identify any additional hazards and risks associated with the use of NGTs compared to conventional breeding techniques in its previous Opinions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. CRISPR/Cas9 editing of Downy mildew resistant 6 (DMR6-1) in grapevine leads to reduced susceptibility to Plasmopara viticola
- Author
-
Djennane, Samia, primary, Gersch, Sophie, additional, Le-Bohec, Françoise, additional, Piron, Marie-Christine, additional, Baltenweck, Raymonde, additional, Lemaire, Olivier, additional, Merdinoglu, Didier, additional, Hugueney, Philippe, additional, Nogué, Fabien, additional, and Mestre, Pere, additional
- Published
- 2023
- Full Text
- View/download PDF
16. POLQ plays a key role in the repair of CRISPR/Cas9-induced double-stranded breaks in the moss Physcomitrella patens
- Author
-
Mara, Kostlend, Charlot, Florence, Guyon-Debast, Anouchka, Schaefer, Didier G., Collonnier, Caécile, Grelon, Mathilde, and Nogué, Fabien
- Published
- 2019
17. Gene Editing in Potato Using CRISPR-Cas9 Technology
- Author
-
Chauvin, Laura, primary, Sevestre, François, additional, Lukan, Tjaša, additional, Nogué, Fabien, additional, Gallois, Jean-Luc, additional, Chauvin, Jean-Eric, additional, and Veillet, Florian, additional
- Published
- 2021
- Full Text
- View/download PDF
18. Assessment of genetically modified maize MON 89034 × 1507 × NK603 for renewal authorisation under Regulation (EC) No 1829/2003 (application GMFF‐2022‐3670).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Camargo, Ana M., Goumperis, Tilemachos, Lenzi, Paolo, and Piffanelli, Pietro
- Subjects
CORN ,TRANSGENIC organisms ,ENVIRONMENTAL monitoring ,FOOD safety ,ENVIRONMENTAL reporting ,CHEMICAL laws - Abstract
Following the submission of dossier GMFF‐2022‐3670 under Regulation (EC) No 1829/2003 from Corteva Agriscience Belgium BV and Bayer Agriculture BV, the Panel on genetically modified organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide‐tolerant and insect‐resistant genetically modified maize MON 89034 × 1507 × NK603, for food and feed uses, excluding cultivation within the European Union. The data received in the context of this renewal application contained post‐market environmental monitoring reports, a systematic search and evaluation of literature, updated bioinformatic analyses and a search for additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. Under the assumption that the DNA sequences of the events in maize MON 89034 × 1507 × NK603 considered for renewal are identical to the sequences of the originally assessed events, the GMO Panel concludes that there is no evidence in renewal dossier GMFF‐2022‐3670 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on maize MON 89034 × 1507 × NK603. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Assessment of genetically modified maize MON 89034 × 1507 × MON 88017 × 59122 and 8 out of 10 of its subcombinations for renewal authorisation under Regulation (EC) No 1829/2003 (dossier GMFF‐2022‐9170)
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Camargo, Ana M., Goumperis, Tilemachos, Lenzi, Paolo, and Piffanelli, Pietro
- Subjects
CORN ,HERBICIDE application ,TRANSGENIC organisms ,ENVIRONMENTAL monitoring ,FOOD safety ,CHEMICAL laws - Abstract
Following the joint submission of dossier GMFF‐2022‐9170 under Regulation (EC) No 1829/2003 from Bayer Agriculture B.V. and Corteva Agriscience Belgium B.V., the Panel on genetically modified organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide tolerant and insect resistant genetically modified maize MON 89034 × 1507 × MON 88017 × 59122 and 8 out of 10 of its subcombinations, for food and feed uses, excluding cultivation within the European Union. The data received in the context of this renewal application contained post‐market environmental monitoring reports, an evaluation of the literature retrieved by a scoping review, a search for additional studies performed by or on behalf of the applicant and updated bioinformatics analyses. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. Under the assumption that the DNA sequences of the events in maize MON 89034 × 1507 × MON 88017 × 59122 and 8 out of 10 of its subcombinations considered for renewal are identical to the sequences of the originally assessed events, the GMO Panel concludes that there is no evidence in renewal dossier GMFF‐2022‐9170 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on maize MON 89034 × 1507 × MON 88017 × 59122 and 8 out of 10 of its subcombinations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. Assessment of genetically modified maize MON 94804 (application GMFF‐2022‐10651).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Gennaro, Andrea, and Gómez Ruiz, José Ángel
- Subjects
CORN ,CORN industry ,TRANSGENIC organisms ,ANIMAL health ,FOOD consumption ,ENVIRONMENTAL monitoring - Abstract
Genetically modified (GM) maize MON 94804 was developed to achieve a reduction in plant height by introducing the GA20ox_SUP suppression cassette. The molecular characterisation and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the agronomic/phenotypic and compositional differences identified between maize MON 94804 and its conventional counterpart needs further assessment, except for ear height, plant height and levels of carbohydrates in forage, which do not raise safety or nutritional concerns. The Panel on Genetically Modified Organisms (GMO Panel) does not identify safety concerns regarding the toxicity and allergenicity of the GA20ox_SUP precursor‐miRNA and derived mature miRNA as expressed in maize MON 94804 and finds no evidence that the genetic modification would change the overall allergenicity of maize MON 94804. In the context of this application, the consumption of food and feed from maize MON 94804 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize MON 94804 is as safe as the conventional counterpart and non‐GM maize varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize MON 94804 grains into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 94804. The GMO Panel concludes that maize MON 94804 is as safe as its conventional counterpart and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. CRISPR/Cas9 editing of Downy mildew resistant 6 (DMR6-1) in grapevine leads to reduced susceptibility to Plasmopara viticola.
- Author
-
Djennane, Samia, Gersch, Sophie, Le-Bohec, Françoise, Piron, Marie-Christine, Baltenweck, Raymonde, Lemaire, Olivier, Merdinoglu, Didier, Hugueney, Philippe, Nogué, Fabien, and Mestre, Pere
- Subjects
DOWNY mildew diseases ,GRAPES ,GRAPE diseases & pests ,CRISPRS ,VITIS vinifera ,SALICYLIC acid ,DISEASE resistance of plants - Abstract
Downy mildew of grapevine (Vitis vinifera), caused by the oomycete Plasmopara viticola, is an important disease that is present in cultivation areas worldwide, and using resistant varieties provides an environmentally friendly alternative to fungicides. DOWNY MILDEW RESISTANT 6 (DMR6) from Arabidopsis is a negative regulator of plant immunity and its loss of function confers resistance to downy mildew. In grapevine, DMR6 is present in two copies, named VvDMR6-1 and VvDMR6-2. Here, we describe the editing of VvDMR6-1 in embryogenic calli using CRISPR/Cas9 and the regeneration of the edited plants. All edited plants were found to be biallelic and chimeric, and whilst they all showed reduced growth compared with non-transformed control plants, they also had reduced susceptibility to P. viticola. Comparison between mock-inoculated genotypes showed that all edited lines presented higher levels of salicylic acid than controls, and lines subjected to transformation presented higher levels of cis-resveratrol than controls. Our results identify VvDMR6-1 as a promising target for breeding grapevine cultivars with improved resistance to downy mildew. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
22. Assessment of genetically modified maize DP202216 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2019‐159).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, Camargo, Ana M., De Sanctis, Giacomo, and Federici, Silvia
- Subjects
CORN ,ANIMAL health ,STEARIC acid ,FOOD consumption ,CORN industry ,ENVIRONMENTAL security ,FOOD labeling - Abstract
Genetically modified maize DP202216 was developed to confer tolerance to glufosinate‐ammonium‐containing herbicides and to provide an opportunity for yield enhancement under field conditions. These properties were achieved by introducing the mo‐pat and zmm28 expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP202216 and its comparator needs further assessment, except for the levels of stearic acid (C18:0), which do not raise nutritional and safety concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the PAT and ZMM28 proteins as expressed in maize DP202216, and finds no evidence that the genetic modification would change the overall allergenicity of maize DP202216. In the context of this application, the consumption of food and feed from maize DP202216 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP202216 is as safe as the comparator and non‐GM reference varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize DP202216 grains into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP202216. The GMO Panel concludes that maize DP202216 is as safe as its comparator and the tested non‐GM reference varieties with respect to potential effects on human and animal health and the environment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. Establishing CRISPR-Cas9 in the sexually dimorphic moss,Ceratodon purpureus
- Author
-
Tavernier, Emilie-Katherine, primary, Lockwood, Emily, additional, Perroud, Pierre-François, additional, Nogué, Fabien, additional, and McDaniel, Stuart F., additional
- Published
- 2023
- Full Text
- View/download PDF
24. RecQ Helicases Function in Development, DNA Repair, and Gene Targeting in Physcomitrella patens
- Author
-
Wiedemann, Gertrud, van Gessel, Nico, Köchl, Fabian, Hunn, Lisa, Schulze, Katrin, Maloukh, Lina, Nogué, Fabien, Decker, Eva L., Hartung, Frank, and Reski, Ralf
- Published
- 2018
25. Crop plants with improved culture and quality traits for food, feed and other uses
- Author
-
Nogué, Fabien, Vergne, Philippe, Chèvre, Anne-Marie, Chauvin, Jean-Eric, Bouchabké-Coussa, Oumaya, Déjardin, Annabelle, Chevreau, Elisabeth, Hibrand-Saint Oyant, Laurence, Mazier, Marianne, Barret, Pierre, Guiderdoni, Emmanuel, Sallaud, Christophe, Foucrier, Séverine, Devaux, Pierre, and Rogowsky, Peter M.
- Published
- 2019
- Full Text
- View/download PDF
26. Efficient and transgene-free gene targeting using Agrobacterium-mediated delivery of the CRISPR/Cas9 system in tomato
- Author
-
Danilo, Benoit, Perrot, Laura, Mara, Kostlend, Botton, Emmanuel, Nogué, Fabien, and Mazier, Marianne
- Published
- 2019
- Full Text
- View/download PDF
27. A Sec14p-Nodulin Domain Phosphatidylinositol Transfer Protein Polarizes Membrane Growth of Arobidopsis thaliana Root Hairs
- Author
-
Vincent, Patrick, Chua, Michael, Nogue, Fabien, Fairbrother, Ashley, Mekeel, Hal, Xu, Yue, Allen, Nina, Bibikova, Tatiana N., Gilroy, Simon, and Bankaitis, Vytas A.
- Published
- 2005
28. Improved Prime Editing allows for routine predictable gene editing in Physcomitrium patens
- Author
-
Perroud, Pierre-François, primary, Guyon-Debast, Anouchka, additional, Casacuberta, Josep M, additional, Paul, Wyatt, additional, Pichon, Jean-Philippe, additional, Comeau, David, additional, and Nogué, Fabien, additional
- Published
- 2023
- Full Text
- View/download PDF
29. New Transformation Technologies for Trees
- Author
-
Alburquerque, Nuria, Baldacci-Cresp, Fabien, Baucher, Marie, Casacuberta, Josep M., Collonnier, Cécile, El Jaziri, Mondher, Nogué, Fabien, Burgos, Lorenzo, Jain, S.Mohan, Series editor, Häggman, Hely, Series editor, Yanchuk, Alvin D., Series editor, Vettori, Cristina, editor, Gallardo, Fernando, editor, Kazana, Vassiliki, editor, Migliacci, Fabio, editor, Pilate, Gilles, editor, and Fladung, Matthias, editor
- Published
- 2016
- Full Text
- View/download PDF
30. The KNAT2 Homeodomain Protein Interacts with Ethylene and Cytokinin Signaling
- Author
-
Hamant, Olivier, Nogué, Fabien, Belles-Boix, Enric, Jublot, Delphine, Grandjean, Olivier, Traas, Jan, and Pautot, Véronique
- Published
- 2002
31. Assessment of genetically modified maize MON 810 for renewal authorisation under Regulation (EC) No 1829/2003 (dossier GMFF‐2022‐9450).
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, M. Camargo, Ana, Goumperis, Tilemachos, Lenzi, Paolo, and Piffanelli, Pietro
- Subjects
CORN ,TRANSGENIC organisms ,ENVIRONMENTAL monitoring ,FOOD safety ,ENVIRONMENTAL reporting ,FOOD labeling ,CHEMICAL laws - Abstract
Following the submission of dossier GMFF‐2022‐9450 under Regulation (EC) No 1829/2003 from Bayer Agriculture BV, the Panel on Genetically Modified Organisms of the European Food Safety Authority was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the insect protected genetically modified maize MON 810, for food and feed uses (including pollen), excluding cultivation within the European Union. The data received in the context of this renewal application contained post‐market environmental monitoring reports, an evaluation of the literature retrieved by a scoping review, additional studies performed by or on behalf of the applicant and updated bioinformatics analyses. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. Under the assumption that the DNA sequence of the event in maize MON 810 considered for renewal is identical to the sequence of the originally assessed event, the GMO Panel concludes that there is no evidence in dossier GMFF‐2022‐9450 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on maize MON 810. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. CRISPR/Cas9-Mediated Knockout of Physcomitrella patens Phytochromes
- Author
-
Ermert, Anna Lena, primary, Nogué, Fabien, additional, Stahl, Fabian, additional, Gans, Tanja, additional, and Hughes, Jon, additional
- Published
- 2019
- Full Text
- View/download PDF
33. N 6 ‐Methyladenosinemodification of mRNA contributes to the transition from 2D to 3D growth in the moss Physcomitrium patens
- Author
-
Garcias‐Morales, David, primary, Palomar, V. Miguel, additional, Charlot, Florence, additional, Nogué, Fabien, additional, Covarrubias, Alejandra A., additional, and Reyes, José L., additional
- Published
- 2023
- Full Text
- View/download PDF
34. Animal dietary exposure in the risk assessment of feed derived from genetically modified plants
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Fernandez Dumont, Antonio, Ardizzone, Michele, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Fernandez Dumont, Antonio, and Ardizzone, Michele
- Abstract
EFSA carries out the risk assessment of genetically modified plants for food and feed uses under Regulation (EU) No 503/2013. Exposure assessment – anticipated intake/extend of use shall be an essential element of the risk assessment of genetically modified feeds, as required by Regulation (EU) No 503/2013. Estimates of animal dietary exposure to newly expressed proteins should be determined to cover average consumption across all the different species, age, physiological and productive phases of farmed and companion animals, and identify and consider particular consumer groups with expected higher exposure. This statement is aimed at facilitating the reporting of the information that applicants need to provide on expected animal dietary exposure to newly expressed proteins and to increase harmonisation of the application dossiers to be assessed by the EFSA GMO Panel. Advice is provided on the selection of proper feed consumption and feed concentration data, and on the reporting of exposure's estimates. An overview of the different uncertainties that may be linked to the estimations is provided. This statement also explains how to access an Excel calculator which should be used in future applications as basis to provide a more consistent presentation of estimates of expected animal dietary exposure.
- Published
- 2023
35. Improved prime editing allows for routine predictable gene editing in Physcomitrium patens
- Author
-
Limagrain Europe, Agence Nationale de la Recherche (France), Perroud, Pierre-François, Guyon-Debast, Anouchka, Casacuberta, Josep M., Paul, Wyatt, Pichon, Jean-Philippe, Comeau, David, Nogué, Fabien, Limagrain Europe, Agence Nationale de la Recherche (France), Perroud, Pierre-François, Guyon-Debast, Anouchka, Casacuberta, Josep M., Paul, Wyatt, Pichon, Jean-Philippe, Comeau, David, and Nogué, Fabien
- Abstract
Efficient and precise gene editing is the gold standard of any reverse genetic study. The recently developed prime editing approach, a modified CRISPR/Cas9 [clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein] editing method, has reached the precision goal but its editing rate can be improved. We present an improved methodology that allows for routine prime editing in the model plant Physcomitrium patens, whilst exploring potential new prime editing improvements. Using a standardized protoplast transfection procedure, multiple prime editing guide RNA (pegRNA) structural and prime editor variants were evaluated targeting the APT reporter gene through direct plant selection. Together, enhancements of expression of the prime editor, modifications of the 3ʹ extension of the pegRNA, and the addition of synonymous mutation in the reverse transcriptase template sequence of the pegRNA dramatically improve the editing rate without affecting the quality of the edits. Furthermore, we show that prime editing is amenable to edit a gene of interest through indirect selection, as demonstrated by the generation of a Ppdek10 mutant. Additionally, we determine that a plant retrotransposon reverse transcriptase enables prime editing. Finally, we show for the first time the possibility of performing prime editing with two independently coded peptides.
- Published
- 2023
36. Risk assessment of additional information on maize MIR162
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Gennaro, Andrea, Neri, Franco Maria, Papadopoulou, Nikoletta, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Gennaro, Andrea, Neri, Franco Maria, and Papadopoulou, Nikoletta
- Abstract
The European Commission requested the Panel on Genetically Modified Organisms of the European Food Safety Authority (EFSA GMO Panel) to assess new scientific information on maize MIR162, and to indicate whether the previous conclusions on the safety of maize MIR162 as a single event and as a part of stacked events remain valid. The new information is included in a European patent that reports a decrease in male fertility in some MIR162 inbred lines, pointing to a potential link between such decrease and the Vip3 protein expressed by maize MIR162. The EFSA GMO Panel evaluated the data provided by the patent owner and found scarce support for a causal link between Vip3 and decreased fertility. The general hypothesis of an association between event MIR162 and altered fertility could not be confirmed. The EFSA GMO Panel conducted the safety assessment based on the conservative assumption that such an association exists. The EFSA GMO Panel concluded that a decrease in male fertility would have no impact on the previous conclusions on maize MIR162 and stacked events containing MIR162.
- Published
- 2023
37. Assessment of genetically modified oilseed rape MS8, RF3 and MS8¿×¿RF3 for renewal authorisation under Regulation (EC) No 1829/2003 (application EFSA-GMO-RX-024)
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, Camargo, Ana M., Fernández, Antonio, Goumperis, Tilemachos, Lenzi, Paolo, Lewandowska, Aleksandra, Raffaello, Tommaso, Streissl, Franz, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, Camargo, Ana M., Fernández, Antonio, Goumperis, Tilemachos, Lenzi, Paolo, Lewandowska, Aleksandra, Raffaello, Tommaso, and Streissl, Franz
- Abstract
Following the submission of application EFSA-GMO-RX-024 under Regulation (EC) No 1829/2003 from BASF Agricultural Solutions Seed US LLC, the Panel on Genetically Modified Organisms of EFSA was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide tolerant genetically modified oilseed rape MS8, RF3 and MS8 × RF3, for food and feed uses, excluding cultivation within the European Union. The data received in the context of this renewal application contained post-market environmental monitoring reports, a systematic search and evaluation of literature, updated bioinformatic analyses, and additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. Under the assumption that the DNA sequences of the events in oilseed rape MS8, RF3 and MS8 × RF3 considered for renewal are identical to the sequences of the originally assessed events, the GMO Panel concludes that there is no evidence in renewal application EFSA-GMO-RX-024 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on oilseed rape MS8, RF3 and MS8 × RF3.
- Published
- 2023
38. Assessment of genetically modified maize MON 87419 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-NL-2017-140)
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Lanzoni, Anna, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana M., Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Raffaello, Tommaso, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Lanzoni, Anna, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana M., Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, and Raffaello, Tommaso
- Abstract
Genetically modified maize MON 87419 was developed to confer tolerance to dicamba- and glufosinate-based herbicides. These properties were achieved by introducing the dmo and pat expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize MON 87419 and its conventional counterpart needed further assessment, except for the levels of arginine and protein in grains which did not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the dicamba mono-oxygenase (DMO) and phosphinothricin N-acetyltransferase (PAT) proteins as expressed in maize MON 87419. The GMO Panel finds no evidence that the genetic modification impacts the overall safety of maize MON 87419. In the context of this application, the consumption of food and feed from maize MON 87419 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize MON 87419 is as safe as the conventional counterpart and non-GM maize varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize MON 87419 grains into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 87419. The GMO Panel concludes that maize MON 87419 is as safe as its conventional counterpart and the tested non-GM maize varieties with respect to potential effects on human and animal health and the environment.
- Published
- 2023
39. Assessment of genetically modified maize Bt11 × MIR162 × MIR604 × MON 89034 × 5307 × GA21 and 30 subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-DE-2018-149)
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lenzi, Paolo, Camargo, Ana M., Neri, Franco Maria, Raffaello, Tommaso, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lenzi, Paolo, Camargo, Ana M., Neri, Franco Maria, and Raffaello, Tommaso
- Abstract
Genetically modified maize Bt11 × MIR162 × MIR604 × MON 89034 × 5307 × GA21 was developed by crossing to combine six single events: Bt11, MIR162, MIR604, MON 89034, 5307 and GA21, the GMO Panel previously assessed the 6 single maize events and 27 out of the 56 possible subcombinations and did not identify safety concerns. No new data on the single maize events or the assessed subcombinations were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in the six-event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that six-event stack maize, as described in this application, is as safe as the conventional counterpart and non-GM maize varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable six-event stack maize grains into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in 29 of the maize subcombinations not previously assessed and covered by the scope of this application and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the six-event stack maize. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize Bt11 × MIR162 × MIR604 × MON 89034 × 5307 × GA21. The GMO Panel concludes that six-event stack maize and the 30 subcombinations covered by the scope of the application are as safe as its conventional counterpart and the tested non-GM maize varieties with respect to potential effects on human and animal health
- Published
- 2023
40. Assessment of genetically modified maize GA21 × T25 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-DE-2016-137)
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Devos, Yann, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lanzoni, Anna, Lenzi, Paolo, Camargo, Ana M., Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Raffaello, Tommaso, Streissl, Franz, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Devos, Yann, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lanzoni, Anna, Lenzi, Paolo, Camargo, Ana M., Neri, Franco Maria, Papadopoulou, Nikoletta, Paraskevopoulos, Konstantinos, Raffaello, Tommaso, and Streissl, Franz
- Abstract
Genetically modified maize GA21 × T25 was developed by crossing to combine two single events: GA21 and T25. The GMO Panel previously assessed the two single maize events and did not identify safety concerns. No new data on the single maize events were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in maize GA21 × T25 does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that maize GA21 × T25, as described in this application, is as safe as its conventional counterpart and the non-GM reference varieties tested, and no post-market monitoring of food and feed is considered necessary. In the case of accidental release of viable maize GA21 × T25 grains into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize GA21 × T25. Post-market monitoring of food and feed is not considered necessary. The GMO Panel concludes that maize GA21 × T25 is as safe as its conventional counterpart and the non-GM reference varieties tested, with respect to potential effects on human and animal health and the environment.
- Published
- 2023
41. Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA-GMO-DE-2017-141)
- Author
-
EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana M., Neri, Franco Maria, Papadopoulou, Nikoletta, Raffaello, Tommaso, EFSA Panel on Genetically Modified Organisms (GMO), Mullins, Ewen, Bresson, Jean-Louis, Dalmay, Tamas, Crawford Dewhurst, Ian, Epstein, Michelle M., Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, F. Javier, Naegeli, Hanspeter, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez-Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana M., Neri, Franco Maria, Papadopoulou, Nikoletta, and Raffaello, Tommaso
- Abstract
Genetically modified cotton COT102 was developed to confer resistance against several lepidopteran species. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the differences in the agronomic-phenotypic and compositional characteristics between cotton COT102 and its non-GM comparator needs further assessment, except for levels of acid detergent fibre, which do not raise safety or nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Vip3Aa19 and APH4 proteins as expressed in cotton COT102 and finds no evidence that the genetic modification would change the overall allergenicity of cotton COT102. In the context of this application, the consumption of food and feed from cotton COT102 does not represent a nutritional concern for humans and animals. The GMO Panel concludes that cotton COT102 is as safe as the non-GM comparator and non-GM cotton varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable cotton COT102 seeds into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of cotton COT102. The GMO Panel concludes that cotton COT102 is as safe as its non-GM comparator and the tested non-GM cotton varieties with respect to potential effects on human and animal health and the environment.
- Published
- 2023
42. Risk assessment of additional information on maize MIR162
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Gennaro, Andrea, Neri, Franco Maria, Papadopoulou, Nikoletta, Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Gennaro, Andrea, Neri, Franco Maria, and Papadopoulou, Nikoletta
- Abstract
The European Commission requested the Panel on Genetically Modified Organisms of the European Food Safety Authority (EFSA GMO Panel) to assess new scientific information on maize MIR162, and to indicate whether the previous conclusions on the safety of maize MIR162 as a single event and as a part of stacked events remain valid. The new information is included in a European patent that reports a decrease in male fertility in some MIR162 inbred lines, pointing to a potential link between such decrease and the Vip3 protein expressed by maize MIR162. The EFSA GMO Panel evaluated the data provided by the patent owner and found scarce support for a causal link between Vip3 and decreased fertility. The general hypothesis of an association between event MIR162 and altered fertility could not be confirmed. The EFSA GMO Panel conducted the safety assessment based on the conservative assumption that such an association exists. The EFSA GMO Panel concluded that a decrease in male fertility would have no impact on the previous conclusions on maize MIR162 and stacked events containing MIR162.
- Published
- 2023
43. Assessment of genetically modified maize GA21 × T25 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2016‐137)
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan Sánchez, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Devos, Yann, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lanzoni, Anna, Lenzi, Paolo, Camargo, Ana Martin, et al, Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan Sánchez, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Álvarez, Fernando, Ardizzone, Michele, De Sanctis, Giacomo, Devos, Yann, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Goumperis, Tilemachos, Kagkli, Dafni Maria, Lanzoni, Anna, Lenzi, Paolo, Camargo, Ana Martin, and et al
- Abstract
Genetically modified maize GA21 x T25 was developed by crossing to combine two single events: GA21 and T25. The GMO Panel previously assessed the two single maize events and did not identify safety concerns. No new data on the single maize events were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins in maize GA21 x T25 does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that maize GA21 x T25, as described in this application, is as safe as its conventional counterpart and the non-GM reference varieties tested, and no post-market monitoring of food and feed is considered necessary. In the case of accidental release of viable maize GA21 x T25 grains into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of maize GA21 x T25. Post-market monitoring of food and feed is not considered necessary. The GMO Panel concludes that maize GA21 x T25 is as safe as its conventional counterpart and the non-GM reference varieties tested, with respect to potential effects on human and animal health and the environment.
- Published
- 2023
44. Animal dietary exposure in the risk assessment of feed derived from genetically modified plants
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Dumont, Antonio Fernandez, Ardizzone, Michele, Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Dumont, Antonio Fernandez, and Ardizzone, Michele
- Abstract
EFSA carries out the risk assessment of genetically modified plants for food and feed uses under Regulation (EU) No 503/2013. Exposure assessment – anticipated intake/extend of use shall be an essential element of the risk assessment of genetically modified feeds, as required by Regulation (EU) No 503/2013. Estimates of animal dietary exposure to newly expressed proteins should be determined to cover average consumption across all the different species, age, physiological and productive phases of farmed and companion animals, and identify and consider particular consumer groups with expected higher exposure. This statement is aimed at facilitating the reporting of the information that applicants need to provide on expected animal dietary exposure to newly expressed proteins and to increase harmonisation of the application dossiers to be assessed by the EFSA GMO Panel. Advice is provided on the selection of proper feed consumption and feed concentration data, and on the reporting of exposure’s estimates. An overview of the different uncertainties that may be linked to the estimations is provided. This statement also explains how to access an Excel calculator which should be used in future applications as basis to provide a more consistent presentation of estimates of expected animal dietary exposure.
- Published
- 2023
45. Assessment of genetically modified cotton COT102 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐DE‐2017‐141)
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Moreno, Francisco Javier, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Fernández, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Goumperis, Tilemachos, Kagli, Dafni Maria, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana M, Neri, Franco Maria, Papadopoulou, Nikoletta, Raffaello, Tommaso, Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Moreno, Francisco Javier, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Fernández, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Goumperis, Tilemachos, Kagli, Dafni Maria, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana M, Neri, Franco Maria, Papadopoulou, Nikoletta, and Raffaello, Tommaso
- Abstract
Genetically modified cotton COT102 was developed to confer resistance against several lepidopteran species. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the differences in the agronomic-phenotypic and compositional characteristics between cotton COT102 and its non-GM comparator needs further assessment, except for levels of acid detergent fibre, which do not raise safety or nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Vip3Aa19 and APH4 proteins as expressed in cotton COT102 and finds no evidence that the genetic modification would change the overall allergenicity of cotton COT102. In the context of this application, the consumption of food and feed from cotton COT102 does not represent a nutritional concern for humans and animals. The GMO Panel concludes that cotton COT102 is as safe as the non-GM comparator and non-GM cotton varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable cotton COT102 seeds into the environment, this would not raise environmental safety concerns. The post-market environmental monitoring plan and reporting intervals are in line with the intended uses of cotton COT102. The GMO Panel concludes that cotton COT102 is as safe as its non-GM comparator and the tested non-GM cotton varieties with respect to potential effects on human and animal health and the environment.
- Published
- 2023
46. Assessment of genetically modified maize MON 87419 for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2017‐140)
- Author
-
Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan Sánchez, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Goumperis, Tilemachos, Lanzoni, Anna, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana Martin, Neri, Franco Maria, Papadopoulou, Nikoletta, et al, Mullins, Ewen, Bresson, Jean‐Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Serrano, Jose Juan Sánchez, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, De Sanctis, Giacomo, Federici, Silvia, Fernandez Dumont, Antonio, Gennaro, Andrea, Gómez Ruiz, José Ángel, Goumperis, Tilemachos, Lanzoni, Anna, Lenzi, Paolo, Lewandowska, Aleksandra, Camargo, Ana Martin, Neri, Franco Maria, Papadopoulou, Nikoletta, and et al
- Abstract
Genetically modified maize MON 87419 was developed to confer tolerance to dicamba- and glufosinate-based herbicides. These properties were achieved by introducing the dmo and pat expression cassettes. The molecular characterisation data and bioinformatic analyses do not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize MON 87419 and its conventional counterpart needed further assessment, except for the levels of arginine and protein in grains which did not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the dicamba mono-oxygenase (DMO) and phosphinothricin N-acetyltransferase (PAT) proteins as expressed in maize MON 87419. The GMO Panel finds no evidence that the genetic modification impacts the overall safety of maize MON 87419. In the context of this application, the consumption of food and feed from maize MON 87419 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize MON 87419 is as safe as the conventional counterpart and non-GM maize varieties tested, and no post-market monitoring of food/feed is considered necessary. In the case of accidental release of viable maize MON 87419 grains into the environment, this would not raise environmental safety concerns. The postmarket environmental monitoring plan and reporting intervals are in line with the intended uses of maize MON 87419. The GMO Panel concludes that maize MON 87419 is as safe as its conventional counterpart and the tested non-GM maize varieties with respect to potential effects on human and animal health and the environment.
- Published
- 2023
47. Assessment of genetically modified oilseed rape MS8, RF3 and MS8 × RF3 for renewal authorisation under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐RX‐024)
- Author
-
Mullins, Ewen, Bresson, Jean Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, Camargo, Ana M, Fernandez, Antonio, Goumperis, Tilemachos, Lenzi, Paolo, Lewandowska, Aleksandra, Raffaello, Tommaso, Streissl, Franz, Mullins, Ewen, Bresson, Jean Louis, Dalmay, Tamas, Dewhurst, Ian Crawford, Epstein, Michelle M, Firbank, Leslie George, Guerche, Philippe, Hejatko, Jan, Moreno, Francisco Javier, Naegeli, Hanspeter; https://orcid.org/0000-0001-5762-1359, Nogué, Fabien, Rostoks, Nils, Sánchez Serrano, Jose Juan, Savoini, Giovanni, Veromann, Eve, Veronesi, Fabio, Ardizzone, Michele, Camargo, Ana M, Fernandez, Antonio, Goumperis, Tilemachos, Lenzi, Paolo, Lewandowska, Aleksandra, Raffaello, Tommaso, and Streissl, Franz
- Abstract
Following the submission of application EFSA-GMO-RX-024 under Regulation (EC) No 1829/2003 from BASF Agricultural Solutions Seed US LLC, the Panel on Genetically Modified Organisms of EFSA was asked to deliver a scientific risk assessment on the data submitted in the context of the renewal of authorisation application for the herbicide tolerant genetically modified oilseed rape MS8, RF3 and MS8 x RF3, for food and feed uses, excluding cultivation within the European Union. The data received in the context of this renewal application contained post-market environmental monitoring reports, a systematic search and evaluation of literature, updated bioinformatic analyses, and additional documents or studies performed by or on behalf of the applicant. The GMO Panel assessed these data for possible new hazards, modified exposure or new scientific uncertainties identified during the authorisation period and not previously assessed in the context of the original application. Under the assumption that the DNA sequences of the events in oilseed rape MS8, RF3 and MS8 x RF3 considered for renewal are identical to the sequences of the originally assessed events, the GMO Panel concludes that there is no evidence in renewal application EFSA-GMO-RX-024 for new hazards, modified exposure or scientific uncertainties that would change the conclusions of the original risk assessment on oilseed rape MS8, RF3 and MS8 x RF3.
- Published
- 2023
48. CHASE domain-containing receptors play an essential role in the cytokinin response of the moss Physcomitrella patens
- Author
-
von Schwartzenberg, Klaus, Lindner, Ann-Cathrin, Gruhn, Njuscha, Šimura, Jan, Novák, Ondřej, Strnad, Miroslav, Gonneau, Martine, Nogué, Fabien, and Heyl, Alexander
- Published
- 2016
49. Design of a comprehensive microfluidic and microscopic toolbox for the ultra-wide spatio-temporal study of plant protoplasts development and physiology
- Author
-
Sakai, Kaori, Charlot, Florence, Le Saux, Thomas, Bonhomme, Sandrine, Nogué, Fabien, Palauqui, Jean-Christophe, and Fattaccioli, Jacques
- Published
- 2019
- Full Text
- View/download PDF
50. Functional analysis of PsbS transmembrane domains through base editing in Physcomitrium patens
- Author
-
Beraldo, Claudia, primary, Guyon‐Debast, Anouchka, additional, Alboresi, Alessandro, additional, Nogué, Fabien, additional, and Morosinotto, Tomas, additional
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.