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In the past, satellite climatologies of gravity waves (GWs) have initiated progress in their representation in global models. However, these could not provide the phase speed and direction distributions needed for a better understanding of the interaction between GWs and the large-scale winds directly. The ESA Earth Explorer 11 candidate CAIRT could provide such observations. CAIRT would use a limb-imaging Michelson interferometer resolving a wide spectral range, allowing temperature and trace gas mixing ratio measurements. With the proposed instrument design, a vertical resolution of 1 km, along-track sampling of 50 km, and across-track sampling of 25 km in a 400 km wide swath will be achieved. In particular, this allows for the observation of three-dimensional (3D), GW-resolving temperature fields throughout the middle atmosphere. In this work, we present the methodology for the GW analysis of CAIRT observations using a limited-volume 3D sinusoidal fit (S3D) wave analysis technique. We assess the capability of CAIRT to provide high-quality GW fields by the generation of synthetic satellite observations from high-resolution model data and comparison of the synthetic observations to the original model fields. For the assessment, wavelength spectra, phase speed spectra, horizontal distributions, and zonal means of GW momentum flux (GWMF) are considered. The atmospheric events we use to exemplify the capabilities of CAIRT are the 2006 sudden stratospheric warming (SSW) event, the quasi-biennial oscillation (QBO) in the tropics, and the mesospheric preconditioning phase of the 2019 SSW event. Our findings indicate that CAIRT would provide highly reliable observations not only of global-scale GW distributions and drag patterns but also of specific wave events and their associated wave parameters. Even under worse-than-expected noise levels of the instrument, the resulting GW measurements are highly consistent with the original model data. Furthermore, we demonstrate that the estimated GW parameters can be used for ray tracing, which physically extends the horizontal coverage of the observations beyond the orbit tracks.

In this work, the features of the structure-conductivity relationship in polar (α) and ion-conducting (β and γ) phases of Na3Fe2(PO4)3 polycrystals obtained by the melt-quenching method have been investigated. Na3Fe2(PO4)3 polycrystals are synthesized by isothermal firing of glassy precursors (after grinding and pressing). The glassy precursors were prepared by melting a pre-calcined (350 C) mixture of initial reagents under the influence of thermal and infrared radiation energy and rapid cooling of the melt (or quenching). It was found that the deformations of the structure of polycrystals α-Na3Fe2(PO4)3 during synthesis by melt-quenching lead to an increase in the conductivity in polar (α) and ion-conducting (β and γ) phases because they contribute to the reduction of structural distortions of the samples. Polycrystals Na3Fe2(PO4)3 obtained by the melt-hardening method have high-quality crystallites, high density, and conductivity, and their synthesis is faster than samples obtained by other methods. The established advantages of synthesized polycrystals of α-Na3Fe2(PO4)3 are probably connected with deformations of structure and chemical activity of glassy precursors caused by nonequilibrium thermodynamic conditions of synthesis. For the first time, it was possible to detect domain structures in polycrystals of α-Na3Fe2(PO4)3 obtained by the melt-quenching method, which confirms the polarity of the α-phase, the appearance of which is associated with the ordered displacement of the cationic sublattice relative to the anionic sublattice under the influence of monoclinic distortion of the crystal framework.

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This article investigates the structures and conductive properties of polycrystals of Na3Fe2(PO4)3 obtained by solid-state and melt synthesis methods using concentrated optical radiation. It has been established that in the melt synthesis method, the material is synthesized under significantly non-equilibrium thermodynamic conditions, leading to the creation of deformations in the sample, which contribute to the enhancement of ionic conductivity. Additionally, the synthesis duration is reduced by half. Through a comparative assessment of the structural parameters and conductive properties of these materials, it is demonstrated that polycrystals obtained by the melt method exhibit better texture and higher ionic conductivity. The occurrence of deformations during the synthesis of α-Na3Fe2(PO4)3 under high temperature-gradient conditions indicates the elasticity of the crystalline framework {[Fe2(PO4)]3−}3∞. It is concluded that the non-equilibrium thermodynamic conditions of α-Na3Fe2(PO4)3 synthesis promote the formation of deformations in the crystalline structure of polycrystals, leading to a partial increase in symmetry and ionic conductivity.

The article presents data on the study of the effect of substitutions of M-cations in the system of Na3Fe2(1-x)Sc2x(PO4)3 solid solutions (in the concentration range 0 ≤ x ≤ 0.06) on the crystal structure, ionic conductivity, and also on the temperature of phase transitions Tα→β , Tβ→γ . It is shown that samples of Na3Fe2(1-x)Sc2x(PO4)3 (0 ≤ x ≤ 0.06) solid solutions are monoclinically distorted, and the structure parameters increase linearly with increasing dopant concentration. Moreover, in the studied samples of solid solutions, an increase in the conductivity of the α -phase and a decrease in the β - and γ -phases are observed, as well as a decrease in the temperatures Tα→β and Tβ→γ . It is concluded that these changes are associated with both local deformations of the anionic part of the crystalline structure{[Fe2(1-x)Sc2x(PO4)]3−}3∞ , and violation of the regularity of the crystal structure.

This article presents the results of a study of the electrochemical properties of cathodes based on polycrystalline samples of Na3Fe2(PO4)3 obtained by solid-phase synthesis and hot pressing. Factors affecting the electrochemical properties of cathodes based on Na3Fe2(PO4)3 obtained by solid-phase synthesis, hot pressing, and sol-gel are established. The prospects of using Na3Fe2(PO4)3 as a cathode material in sodium-ion batteries and the expediency of further modification of this compound in order to improve its electrochemical properties are substantiated.

In this work, the features of the structure-conductivity relationship in polar (α) and ion-conducting (β and γ) phases of Na3Fe2(PO4)3 polycrystals obtained by the melt-quenching method have been investigated. Na3Fe2(PO4)3 polycrystals are synthesized by isothermal firing of glassy precursors (after grinding and pressing). The glassy precursors were prepared by melting a pre-calcined (350 C) mixture of initial reagents under the influence of thermal and infrared radiation energy and rapid cooling of the melt (or quenching). It was found that the deformations of the structure of polycrystals α-Na3Fe2(PO4)3 during synthesis by melt-quenching lead to an increase in the conductivity in polar (α) and ion-conducting (β and γ) phases because they contribute to the reduction of structural distortions of the samples. Polycrystals Na3Fe2(PO4)3 obtained by the melt-hardening method have high-quality crystallites, high density, and conductivity, and their synthesis is faster than samples obtained by other methods. The established advantages of synthesized polycrystals of α-Na3Fe2(PO4)3 are probably connected with deformations of structure and chemical activity of glassy precursors caused by nonequilibrium thermodynamic conditions of synthesis. For the first time, it was possible to detect domain structures in polycrystals of α-Na3Fe2(PO4)3 obtained by the melt-quenching method, which confirms the polarity of the α-phase, the appearance of which is associated with the ordered displacement of the cationic sublattice relative to the anionic sublattice under the influence of monoclinic distortion of the crystal framework. [ABSTRACT FROM AUTHOR]

This article studies the influence of solid-phase (type 1 samples) and melt-quenching (type 2 samples) technological modes of obtaining Na3Fe2(PO4)3 polycrystals on their structures and ion-conducting properties. α-Na3Fe2(PO4)3 polycrystals of the 1st type are formed predominantly under an isothermal firing regime, and the synthesis of the 2nd type is carried out under sharp temperature gradient conditions, contributing to the formation of glassy precursors possessing a reactive and deformed structure, in which the crystallization of crystallites occurs faster than in precursors obtained under isothermal firing. The elemental composition of α-Na3Fe2(PO4)3 type 2 polycrystals is maintained within the normal range despite the sharp non-equilibrium thermodynamic conditions of synthesis. The microstructure of the type 1 Na3Fe2(PO4)3 polycrystals is dominated by chaotically arranged crystallites of medium (7–10 μm) and large (15–35 μm) sizes, while the polycrystals of type 2 are characterized by the preferential formation of small (3–4 μm) and medium (7–10 μm) crystallites, causing uniaxial deformations in their structure, which contribute to a partial increase in their symmetry. The advantage of type 2 polycrystals is that they have higher density and conductivity and are synthesized faster than type 1 samples by a factor of 4. The article also considers the issues of crystallization in a solid-phase precursor from the classical point of view, i.e., the process of the formation of small solid-phase nuclei in the metastable phase and their growth to large particles due to association with small crystallites using phase transitions. Possible variants and models of crystallite growth in Na3Fe2(PO4)3 polycrystals, as well as distinctive features of crystallization between two types of samples, are discussed. [ABSTRACT FROM AUTHOR]

In this paper influence of the excess Ca and Cu cations on the critical temperature (Tc) and critical transport current density (Jc) of high-temperature superconducting ceramics of the compositions (HTSC) Bi1.6Pb0.4Sr2Ca2.1Cu3.1Oy, Bi1.6Pb0.4Sr2Ca2.25Cu3.25Oy and Bi1.6Pb0.4Sr2Ca3Cu4Oy synthesized by the glass-ceramic method has been studied. The synthesis of superconducting ceramics was carried out on the basis of the glass phase, obtained by ultra-fast quenching of the melt. Melting of the mixture of starting components was carried out without the use of a crucible under the influence of IR radiant heating. Analysis of the elemental composition of the samples of the initial precursors showed a significant deviation from stoichiometry in oxygen (increase), as well as a decrease in calcium content. The synthesis of HTSC ceramics was carried out at a temperature of 849–850 °C for 96 h with intermediate grinding every 24 h. Studies of the phase composition of ceramic samples by X-ray diffraction have shown that HTSC ceramics consist only of a superconducting high-temperature phase Bi-2223. Studies of current-carrying characteristics by the four-point probe method according to the criterion of 1 µV/cm2 have shown that high-temperature superconducting ceramics of the compositions Bi1.6Pb0.4Sr2Ca2.1Cu3.1Oy, Bi1.6Pb0.4Sr2Ca2.25Cu3.25Oy and Bi1.6Pb0.4Sr2Ca3Cu4Oy have an increased density of critical transport current of 9.12 A/cm2, 7.62 A/cm2 and 7.26 A/cm2, respectively. At the same time, it was found that with a decrease in the content of Ca and Cu cations in HTSC ceramics, an increase in the critical current density is observed.

In this research, the structure parameters, conducting and dielectric properties of Na3Fe2(PO4)3 and Na2FePO4F polycrystals were studied obtained by solid-phase synthesis. The phase transition temperatures, conducting and dielectric parameters of Na3Fe2(PO4)3 and Na2FePO4F polycrystals were refined. A comparative evaluation of the conductive properties of Na3Fe2(PO4)3 and Na2FePO4F polycrystals is given in this article. The prospects of using of Na3Fe2(PO4)3 and Na2FePO4F are justified as electrode materials in sodium ion batteries.

IntroductionVaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is approved and recommended for immunocompromised patients such as patients after allogeneic stem cell transplantation (allo-SCT). Since infections represent a relevant cause of transplant related mortality we analyzed the advent of immunization to SARS-CoV-2 vaccination in a bicentric population of allogeneic transplanted patients.MethodsWe retrospectively analyzed data of allo-SCT recipients in two German transplantation centers for safety and serologic response after two and three SARS-CoV-2 vaccinations. Patients received mRNA vaccines or vector-based vaccines. All patients were monitored for antibodies against SARS-CoV2-spike protein (anti-S-IgG) with an IgG ELISA assay or an EIA Assay after two and three doses of vaccination.ResultsA total of 243 allo-SCT patients underwent SARS-CoV-2 vaccination. The median age was 59 years (range 22-81). While 85% of patients received two doses of mRNA vaccines, 10% had vector-based vaccines and 5% received a mixed vaccination. The two vaccine doses were well tolerated with only 3% patients developing a reactivation of graft versus host disease (GvHD). Overall, 72% of patients showed a humoral response after two vaccinations. In the multivariate analysis age at time of allo-SCT (p=0.0065), ongoing immunosuppressive therapy (p= 0.029) and lack of immune reconstitution (CD4-T-cell counts

Polycystic ovary syndrome (PCOS) is one of the major endocrine disorders faced by 5-10% of women in their childbearing period. Characterized by raised androgen levels, irregularities in menses and/or polycystic ovaries, the best description that can be linked to PCOS would then be a syndrome including hyperandrogenism, chronic anovulation, and polycystic ovaries. PCOS is a heterogeneous condition associated with many potentially co-occurring disorders, including insulin resistance, obesity and infertility, type 2 diabetes mellitus, cardiovascular disease and even endometrial cancer. The exact causes of this syndrome are yet unknown, though genes, metabolism, malfunction of the endocrine system, and environmental factors are claimed to be involved. Hyperandrogenism manifests itself in the difficulty of follicles to grow and develop, forming small cysts in the ovaries, creating anovulation, contributing to menstrual changes. Modest amounts of weight loss, such as 5%, can be associated with improved endocrine profile and increased likelihood of ovulation and pregnancy. PCOS is treated by means of lifestyle modifications in the form of diet and exercise, medications like clomiphene citrate or metformin, and surgical measures like laparoscopic ovarian drilling only in a few. Diagnosis at an early stage and early institution of treatment are very important to prevent or at least delay the long-term complications of PCOS. With proper management, most women can achieve regularity in menses, ovulation, and finally, successful pregnancy. [ABSTRACT FROM AUTHOR]

In the past, satellite climatologies of gravity waves (GWs) have initiated progress in their representation in global models. However, these could not provide the phase speed and direction distributions needed for a better understanding of the interaction between GWs and the large-scale winds directly. The ESA Earth Explorer 11 candidate CAIRT could provide such observations. CAIRT would use a limb-imaging Michelson interferometer resolving a wide spectral range, allowing temperature and trace gas mixing ratio measurements. With the proposed instrument design, a vertical resolution of 1 km, along-track sampling of 50 km, and across-track sampling of 25 km in a 400 km wide swath will be achieved. In particular, this allows for the observation of three-dimensional (3D), GW-resolving temperature fields throughout the middle atmosphere. In this work, we present the methodology for the GW analysis of CAIRT observations using a limited-volume 3D sinusoidal fit (S3D) wave analysis technique. We assess the capability of CAIRT to provide high-quality GW fields by the generation of synthetic satellite observations from high-resolution model data and comparison of the synthetic observations to the original model fields. For the assessment, wavelength spectra, phase speed spectra, horizontal distributions, and zonal means of GW momentum flux (GWMF) are considered. The atmospheric events we use to exemplify the capabilities of CAIRT are the 2006 sudden stratospheric warming (SSW) event, the quasi-biennial oscillation (QBO) in the tropics, and the mesospheric preconditioning phase of the 2019 SSW event. Our findings indicate that CAIRT would provide highly reliable observations not only of global-scale GW distributions and drag patterns but also of specific wave events and their associated wave parameters. Even under worse-than-expected noise levels of the instrument, the resulting GW measurements are highly consistent with the original model data. Furthermore, we demonstrate that the estimated GW parameters can be used for ray tracing, which physically extends the horizontal coverage of the observations beyond the orbit tracks. [ABSTRACT FROM AUTHOR]

Abstract Polycythemia vera (PV) is a BCR-ABL1-negative myeloproliferative neoplasm (MPN) characterized by excessive proliferation of erythroid, myeloid, and megakaryocytic components in the bone marrow, mainly due to a Janus kinase 2 gene mutation (JAK2 V617F). Givinostat, a histone-deacetylase inhibitor that selectively targets JAK2 V617F cell growth, has demonstrated good efficacy and safety in three phase 1/2 studies in patients with PV. This manuscript focuses on the 4-year mean (2.8 year median) follow-up of an open-label, long-term study that enrolled 51 patients with PV (out of a total of 54 with MPN) who received clinical benefit from givinostat in these previous studies or on compassionate use, and who continued to receive givinostat at the last effective and tolerated dose. The primary objectives are to determine givinostat’s long-term safety and tolerability, and efficacy evaluated by the investigators according to internationally recognized response criteria. During follow-up, only 10% of PV patients reported Grade 3 treatment-related adverse events (AEs), while none had Grade 4 or 5 treatment-related AEs. The overall response rate for the duration of follow-up was always greater than 80% in patients with PV. In conclusion, givinostat demonstrated a good safety and efficacy profile in patients with PV, data supporting long-term use in this population.

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Neuroinflammation is increasingly recognized as a pivotal factor not only in neurodegenerative diseases such as Alzheimer's and Parkinson's, but also in the pathogenesis of metabolic disorders that influence or exacerbate these conditions. This review explores the intricate relationships between neuroinflammation, metabolic dysregulation and neurodegenerative diseases. We begin by detailing the fundamental mechanisms of neuroinflammation, focusing on the roles of astrocytes and microglia, and the molecular pathways that contribute to inflammatory processes in the CNS. The discussion then shifts to how metabolic abnormalities such as obesity, insulin resistance and dyslipidemia can initiate or perpetuate neuroinflammatory responses. Furthermore, we examine the evidence linking neuroinflammation to various neurodegenerative diseases, delineating how inflammatory processes can exacerbate neurodegeneration through feedback loops that impair neuronal function and survival. We also review clinical and preclinical studies that provide insights into the bi-directional interactions between neurodegeneration and metabolic health. This includes a critical evaluation of current therapeutic strategies targeting neuroinflammation, ranging from conventional anti-inflammatory treatments to innovative approaches aimed at modulating metabolic factors. Lastly, the review identifies promising therapeutic avenues, challenges in current treatment paradigms, and the potential for integrative interventions that address both metabolic and inflammatory components. Our goal is to emphasize the need for comprehensive strategies that consider the complexity of these intertwined systems in the treatment of neurodegenerative and metabolic diseases. [ABSTRACT FROM AUTHOR]

The electrical conductivity of GMZ grade graphite irradiated by fast neutrons with fluence of 2.22*1019 n/cm² in the temperature range of 298e448 K was studied. It is shown that the more neutrons fluence, than the more the electrical conductivity of the material decreases. [ABSTRACT FROM AUTHOR]

This article investigates the structures and conductive properties of polycrystals of Na3Fe2(PO4)3 obtained by solid-state and melt synthesis methods using concentrated optical radiation. It has been established that in the melt synthesis method, the material is synthesized under significantly non-equilibrium thermodynamic conditions, leading to the creation of deformations in the sample, which contribute to the enhancement of ionic conductivity. Additionally, the synthesis duration is reduced by half. Through a comparative assessment of the structural parameters and conductive properties of these materials, it is demonstrated that polycrystals obtained by the melt method exhibit better texture and higher ionic conductivity. The occurrence of deformations during the synthesis of α-Na3Fe2(PO4)3 under high temperature-gradient conditions indicates the elasticity of the crystalline framework {[Fe2(PO4)]3−}3∞. It is concluded that the non-equilibrium thermodynamic conditions of α-Na3Fe2(PO4)3 synthesis promote the formation of deformations in the crystalline structure of polycrystals, leading to a partial increase in symmetry and ionic conductivity. [ABSTRACT FROM AUTHOR]

Ceramic samples with compositions along the (1 – 2x)BiScO3·(2 – y)xPbTiO3∙yxPbMg1/3Nb2/3O3 (y = 1.2, 1.0, 0.9, 0.5) sections in the BiScO3–PbTiO3–PbMg1/3Nb2/3O3 (BS–PT–PMN) system have been characterized by X-ray diffraction and dielectric, piezoelectric, and thermally stimulated depolarization current measurements. The materials with 1 – x ≲ 0.5 have been shown to consist of perovskite solid solutions. With increasing BS content, the symmetry of the solid solutions rises from tetragonal to cubic. In the intermediate composition region (morphotropic region (MR)), the samples consist of a mixture of solid solutions differing in symmetry. We have located the MR boundaries and examined the effect of composition on the dielectric and piezoelectric properties of the solid solutions. [ABSTRACT FROM AUTHOR]

IntroductionHigh-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) represents a standard treatment regime for multiple myeloma (MM) patients. Common and potentially fatal side effects after auto-HSCT are infections due to a severely compromised immune system with hampered humoral and cellular immunity. This study delineates in depth the quantitative and functional B cell defects and investigates underlying extrinsic or intrinsic drivers.MethodsPeripheral blood of MM patients undergoing high-dose chemotherapy and auto-HSCT (before high-dose chemotherapy and in early reconstitution after HSCT) was studied. Absolute numbers and distribution of B cell subsets were analyzed ex vivo using flow cytometry. Additionally, B cell function was assessed with T cell dependent (TD) and T cell independent (TI) stimulation assays, analyzing proliferation and differentiation of B cells by flow cytometry and numbers of immunoglobulin secreting cells in ELISpots.ResultsQuantitative B cell defects including a shift in the B cell subset distribution occurred after auto-HSCT. Functionally, these patients showed an impaired TD as well as TI B cell immune response. Individual functional responses correlated with quantitative alterations of CD19+, CD4+, memory B cells and marginal zone-like B cells. The TD B cell function could be partially restored upon stimulation with CD40L/IL-21, successfully inducing B cell proliferation and differentiation into plasmablasts and immunoglobulin secreting cells.ConclusionQuantitative and functional B cell defects contribute to the compromised immune defense in MM patients undergoing auto-HSCT. Functional recovery upon TD stimulation and correlation with CD4+ T cell numbers, indicate these as extrinsic drivers of the functional B cell defect. Observed correlations of CD4+, CD19+, memory B and MZ-like B cell numbers with the B cell function suggest that these markers should be tested as potential biomarkers in prospective studies.

Inhibitors of fibroblast growth factor receptor (FGFR) signaling have been investigated in various human cancer diseases. Recently, the first compounds received FDA approval in biomarker-selected patient populations. Different approaches and technologies have been applied in clinical trials, ranging from protein (immunohistochemistry) to mRNA expression (e.g., RNA in situ hybridization) and to detection of various DNA alterations (e.g., copy number variations, mutations, gene fusions). We review, here, the advantages and limitations of the different technologies and discuss the importance of tissue and disease context in identifying the best predictive biomarker for FGFR targeting therapies.