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23 results on '"Noetzli, Leila J."'

14. ETV6 Regulates Pax5 Expression in Early B Cell Development

Author

Jones, Courtney L., primary, Kirkpatrick, Gregory, additional, Fleenor, Courtney, additional, Seth, Welsh, additional, Noetzli, Leila J, additional, Fosmire, Susan, additional, Baturin, Dmitry, additional, Liang, Xiayuan, additional, Hernandez, Giovanny, additional, Pietras, Eric Martin, additional, Jordan, Craig T, additional, Rowley, Jesse W, additional, Di Paola, Jorge, additional, Hagman, James R., additional, and Porter, Christopher C., additional

Published
2016
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15. Pulmonary function in thalassaemia major and its correlation with body iron stores

Author

Sohn, Eugene Y, Noetzli, Leila J, Gera, Aakanksha, Kato, Roberta, Coates, Thomas D., Harmatz, Paul, Keens, Thomas G, and Wood, John C

Subjects
Adult, Lung Diseases, Male, Iron Overload, Adolescent, Iron, Myocardium, beta-Thalassemia, respiratory system, Middle Aged, Article, respiratory tract diseases, Respiratory Function Tests, Pulmonary Disease, Chronic Obstructive, Young Adult, Liver, Respiratory Mechanics, Humans, Female, Child, Lung, Pancreas
Abstract

This study compared pulmonary function tests (PFTs) with cardiac, pancreatic and liver iron in 76 thalassemia major (TM) patients. Restrictive lung disease was observed in 16%, hyperinflation in 32%, and abnormal diffusing capacity in 3%. While no patients met Global Initiative for Chronic Lung Disease criteria for airways obstruction, there were indicators of small airways disease and air trapping. PFTs did not correlate with somatic iron burden, blood counts or haemolysis. Restrictive lung disease was associated with inflammation. We conclude that TM patients have pulmonary abnormalities consistent with small airways obstruction. Restrictive disease and impaired diffusion are less common.

Published
2011

22. Cell cycle-dependent centrosome clustering precedes proplatelet formation.

Author

Becker, Isabelle C., Wilkie, Adrian R., Nikols, Emma, Carminita, Estelle, Roweth, Harvey G., Tilburg, Julia, Sciaudone, Anthony R., Noetzli, Leila J., Fatima, Farheen, Couldwell, Genevieve, Ray, Anjana, Mogilner, Alex, Machlus, Kellie R., and Italiano Jr., Joseph E.

Subjects
*CELL cycle, *PLATELET count, *POLYPLOIDY, *BONE marrow, *KINESIN, *INTERPHASE
Abstract

Platelet-producing megakaryocytes (MKs) primarily reside in the bone marrow, where they duplicate their DNA content with each cell cycle resulting in polyploid cells with an intricate demarcation membrane system. While key elements of the cytoskeletal reorganizations during proplatelet formation have been identified, what initiates the release of platelets into vessel sinusoids remains largely elusive. Using a cell cycle indicator, we observed a unique phenomenon, during which amplified centrosomes in MKs underwent clustering following mitosis, closely followed by proplatelet formation, which exclusively occurred in G1 of interphase. Forced cell cycle arrest in G1 increased proplatelet formation not only in vitro but also in vivo following short-term starvation of mice. We identified that inhibition of the centrosomal protein kinesin family member C1 (KIFC1) impaired clustering and subsequent proplatelet formation, while KIFC1-deficient mice exhibited reduced platelet counts. In summary, we identified KIFC1- and cell cycle-mediated centrosome clustering as an important initiator of proplatelet formation from MKs. [ABSTRACT FROM AUTHOR]

Published
2024
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23. ETV6 Regulates Pax5Expression in Early B Cell Development

Author

Jones, Courtney L., Kirkpatrick, Gregory, Fleenor, Courtney, Seth, Welsh, Noetzli, Leila J, Fosmire, Susan, Baturin, Dmitry, Liang, Xiayuan, Hernandez, Giovanny, Pietras, Eric Martin, Jordan, Craig T, Rowley, Jesse W, Di Paola, Jorge, Hagman, James R., and Porter, Christopher C.

Abstract

Recent studies from our group and others have revealed a role for ETV6germline mutations in the predisposition to ALL. Although ETV6 is among the most commonly mutated genes in ALL, its mechanistic role in leukemogenesis remains unclear. ETV6 is an ETS family transcription factor. ETV6 regulates gene transcription through homo- and hetero- oligomerization with other ETS family members and transcriptional repressors. The germline mutation (P214L amino acid change) identified by our group and others impairs the transcriptional activity and nuclear localization of ETV6 in a dominant negative fashion. The goal of this project is to determine the role of ETV6 in early B cell development and define how germline ETV6mutations result in predisposition to leukemia.

Published
2016
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