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1. A Prospective Multicenter Trial Evaluating Diagnostic Validity of Multivariate Analysis and Individual Serum Marker in Differential Diagnosis of Pancreatic Cancer from Benign Pancreatic Diseases

Author

Motoji Kitagawa, Toshiyuki Furukawa, Kumiko Kurimoto, Nobuyoshi Kuno, Masanori Fukushima, Takaharu Kondo, Satoru Naruse, Hiroshi Ishiguro, Tetsuo Takayama, Yuji Horiguchi, Tetsuo Hayakawa, and Aiji Noda

Subjects
Oncology, medicine.medical_specialty, Pathology, Pancreatic disease, CA-19-9 Antigen, medicine.medical_treatment, Diagnosis, Differential, Endocrinology, Predictive Value of Tests, Internal medicine, Pancreatic cancer, Multicenter trial, Biomarkers, Tumor, Prevalence, medicine, Humans, Diagnosis, Computer-Assisted, Prospective Studies, Prospective cohort study, Pancreas, Tumor marker, business.industry, Gastroenterology, Pancreatic Diseases, Reproducibility of Results, medicine.disease, Pancreatic Neoplasms, Radiation therapy, medicine.anatomical_structure, ROC Curve, Evaluation Studies as Topic, Multivariate Analysis, Differential diagnosis, business
Abstract

A multivariate analysis of CAMPAS-PX2 can increase its diagnostic accuracy in differential diagnosis of pancreatic cancer from benign pancreatic or extrapancreatic disease, when compared with CA19-9 alone. However, the improvement in diagnostic accuracy is still not satisfactory in spite of an elaborate combination of serum markers in diagnosis for pancreatic cancer. Optimal combination of a sensitive serum marker and another diagnostic modality, such as ultrasonography, can be a practical way to improve important diagnostic and cost-effectiveness in diagnosis for pancreatic cancer.No specific biological test has yet been developed for diagnosis of pancreatic cancer, although increasing numbers of tumor markers become available. For improvement in the diagnostic and cost effectiveness, it is important to select optimal combination of several serum markers relatively independent of each other.A new model of discriminant function, computer-aided multivariate and pattern analysis system for pancreatic cancer examination 2 (CAMPAS-PX2), was developed based on the data of the 23 serum tumor markers from the first prospective trial (1) to differentiate between pancreatic cancer and benign pancreatobiliary disease by logistic regression analysis using a stepwise selection method. In 243 patients suspected of having pancreatic pancreatic cancer by a multicenter prospective study, the diagnostic value of the multivariate analysis, CAMPAS-PX2, was compared with the 23 markers.Pancreatic cancer was subsequently identified in 27 patients. Positive in disease, negative in health, and area under receiver operating characteristic curve were significantly higher by CAMPAS-PX2 (89, 87, 91%) than by CA 19-9 (78, 82, 84%), the most sensitive marker among the 23 markers.

Published
1999
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2. Pancreatic Stone Protein and Lactoferrin in Human Pancreatic Juice in Chronic Pancreatitis

Author

Satoru Naruse, Nobuyoshi Kuno, Koji Ochi, Tetsuo Hayakawa, Shinobu Hayakawa, Hideo Harada, Motoji Kitagawa, Yasuyuki Nakae, and Kumiko Kurimoto

Subjects
Adult, Male, medicine.medical_specialty, Pancreatic disease, Endocrinology, Diabetes and Metabolism, Nerve Tissue Proteins, Immunoenzyme Techniques, Pathogenesis, Endocrinology, Pancreatic Juice, Internal medicine, Lithostathine, Internal Medicine, Humans, Medicine, Pancreas, Aged, Hepatology, biology, Lactoferrin, business.industry, Calcium-Binding Proteins, Middle Aged, medicine.disease, eye diseases, medicine.anatomical_structure, Pancreatitis, Chronic Disease, Pancreatic juice, biology.protein, Female, Antibody, business
Abstract

Lactoferrin and pancreatic stone protein (PSP) are thought to be closely related to pancreatic stone formation in chronic pancreatitis. However, the results reported so far have not been conclusive. To reevaluate the pathological importance of PSP in chronic pancreatitis, compared to lactoferrin, levels of PSP were determined by applying an immunoassay specific to PSP to pure pancreatic juice taken from a total of 52 patients. The patients consisted of 16 controls, 19 chronic pancreatitis patients (13 noncalcified and 6 calcified), and 17 probable cases of pancreatitis. The monoclonal antibody PSP antagonist used in the study recognizes both forms of the protein, PSP S1 and S2-5, with equal effectiveness. No significant reduction of PSP was observed in either calcified (mean +/- SEM, 111 +/- 30 micrograms/mg and 24 +/- 3 micrograms/mg protein) or noncalcified (305 +/- 133 and 97 +/- 47) chronic pancreatitis patients compared with controls (85 +/- 23 and 34 +/- 16). PSP levels did not decrease, at least not in the complete forms of the protein found in chronic pancreatitis. PSP antibody and assay results indicated that a reduction of PSP S2-5 alone could not be ruled out in chronic pancreatitis either.

Published
1995
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3. Abstracts of selected papers presented at the 33rd annual meeting of the japanese society of gastroenterology

Author

Daigo Fujii, Masafumi Suyama, Masanori Sugiyama, Yutaka Atomi, Kazuo Inui, Saburo Nakazawa, Kimihiro Nakajima, Hiroyuki Katoh, Makoto Kaneda, Yoshifumi Ogura, Toshifumi Eto, Tsukasa Tsunoda, Masayuki Uchimura, Kazuyuki Narita, Atsushi Sugioka, Toshiharu Tsuzuki, Keiichiro Kanemitsu, Seiki Tashiro, Tatsuya Yoshikawa, Fujio Hanyu, Satoshi Kondo, Yuji Nimura, Naofumi Eriguchi, Toshimichi Nakayama, Masahiro Mitake, Yasuo Naitoh, T. Isawa, A. Okamoto, Hiroshi Miyazaki, Yoshirou Ogata, Nobuyoshi Kuno, Kumiko Kurimoto, Tohru Noguchi, Masatoshi Makuuchi, Takaaki Ikari, Joe Ariyama, Sonshin Takao, Hisaaki Shimazu, Masao Kobari, Seiki Matsuno, K. Tanigawa, R. Mizumoto, T. Nakasako, F. Hanyu, Naoyuki Saito, Takehisa Hiraoka, Osamu Ishikawa, Shingi Imaoka, Naoyuki Miyazaki, Yoichi Saitoh, Akio Harada, Hiroshi Takagi, Y. Kawai, S. Yamamoto, Ryo Nakanishi, Tomoe Beppu, Shunichi Okushiba, Hiroaki Sakamoto, Katsutoshi Obara, Masahito Toba, Masahiko Onda, Masayoshi Azuma, Toru Kashiwagi, Michihiro Sumino, Atsushi Toyonaga, Masaru Hagiwara, Masahiro Sakai, Shigehiro Kokubu, Hisao Shibata, Hirofumi Miyoshi, Shinya Orino, Tomoharu Yoshida, Tadahiko Itoh, Naoya Murashima, Masahiko Matsumura, Tadasu Tsujii, Takashi Murayama, Yukihiko Tameda, Shoichi Matsutani, Hiroshi Ishii, Yoshinobu Mitarai, Michio Kobayashi, Hitoshi Nishida, Taiji Kawada, Hiroko Matsuda, Tsunehisa Kawasaki, Tetsuo Arakawa, Kenzo Kobayashi, Shinichi Ota, Akira Terano, Masahiko Nakamura, Masaya Oda, Akira Tari, Goso Yamamoto, Eiichi Saito, Yutaka Matsuo, Motowo Mizuno, Jun Tomoda, Shuji Asada, Hiroya Takiuchi, Mizuhiro Mogi, Masaki Kitajima, Kouichi Nagano, Nobuhiro Sato, Yuji Naito, Toshikazu Yoshikawa, Masahiro Asaka, Yasuo Sato, Mitsuya Iwafuchi, Hidenobu Watanabe, Yukio Yoshida, Ken Kihira, Hideyuki Kashiwagi, Teruaki Aoki, Masahiro Nishikawa, Takashi Suzuki, Toshiyuki Matsui, Mitsuo Iida, H. Katoh, A. Munakata, Minoru Itsuno, Kazuya Makiyama, Toshifumi Hibi, Tetsuji Kitahora, Masahiro Igarashi, Tomoe Katsumata, Masamichi Satomi, Makoto Yamamura, Ichiro Hirata, Premysl Slezak, Yoshiro Kubota, Tetsuichiro Muto, Kimitomo Morise, Kazuo Kusugami, Akira Sugita, Tsuneo Fukushima, Mitsuo Okada, Toshihiro Sakurai, Atsushi Kawasaki, Nobuo Hiwatashi, Hideo Yamazaki, Tetsuharu Oriishi, Ei Sasaki, Masakazu Takazoe, Noboru Inoue, Y. Funayama, and S. Matsuno

Subjects
Gastroenterology
Published
1993
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4. Evaluation of the effect of pancreatic resection in advanced pancreatic cancer with special reference using hospital-free survival as a measure of quality of life

Author

Kumiko Kurimoto, Takeshi Morimoto, Junichi Sakamoto, Mitsunori Yasue, Nobuyoshi Kuno, Kenzo Yasui, Yasuo Ohashi, and Satoshi Teramukai

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Gastroenterology, Pancreatectomy, Quality of life, Internal medicine, Pancreatic cancer, medicine, Humans, Radiology, Nuclear Medicine and imaging, Stage (cooking), Neoplasm Metastasis, Pancreatic resection, Surrogate endpoint, business.industry, Carcinoma, Ductal, Breast, Cancer, Cancer Care Facilities, General Medicine, Middle Aged, medicine.disease, Prognosis, Hospitalization, Pancreatic Neoplasms, Quality of Life, Female, business
Abstract

Comparisons of surgical procedures and the identification of prognostic factors in pancreatic cancer were carried out on 158 patients who underwent surgery in Aichi Cancer Center from 1975 to 1991 for advanced pancreatic ductal adenocarcinoma. Survival and 'hospital-free survival (HFS), which we consider the best general means of measuring quality of life (QOL) in such severe and often fatal disease, were identified as primary end points, and the effect of pancreatectomy, compared with palliative surgery (by-pass operation, etc.) for TNM Stages III and IV pancreatic cancer was evaluated. Both survival and HFS were significantly longer in the group of patients who underwent pancreatectomies (R group, n 25) compared to the group without pancreatic resection (NR group, n 35) in Stage III cases. In Stage IV cases, however, no significant difference was observed between the R (n 12) and NR (n 86) groups. From these results, we conclude that an extensive pancreatic resection against Stage III pancreatic cancer may improve prognosis. For Stage IV pancreatic cancers, however, aggressive surgery might not always be beneficial either for survival or for QOL.

Published
1995

5. Effectiveness of multivariate analysis of tumor markers in diagnosis of pancreatic carcinoma: a prospective study in multiinstitutions

Author

Akira Sakakibara, Yuji Horiguchi, Toshihito Furukawa, Tetsuo Hayakawa, Masanori Fukushima, Tokimune Shibata, Kumiko Kurimoto, Yukio Iinuma, S. Nakano, Naoyuki Katada, Aiji Noda, Tetsuo Takayama, Nobuyoshi Kuno, and Toshiyuki Suzuki

Subjects
Oncology, Male, medicine.medical_specialty, Pathology, Multivariate analysis, Pancreatic disease, CA-19-9 Antigen, Endocrinology, Diabetes and Metabolism, Tissue Polypeptide Antigen, Endocrinology, Internal medicine, Pancreatic cancer, Internal Medicine, Carcinoma, medicine, Biomarkers, Tumor, Humans, Antigens, Tumor-Associated, Carbohydrate, False Positive Reactions, Diagnosis, Computer-Assisted, Prospective Studies, Prospective cohort study, False Negative Reactions, Aged, Hepatology, Epithelioma, L-Lactate Dehydrogenase, Pancreatic Elastase, business.industry, Reproducibility of Results, Lipase, Middle Aged, medicine.disease, Alkaline Phosphatase, Pancreatic Neoplasms, medicine.anatomical_structure, ROC Curve, Amylases, Multivariate Analysis, Regression Analysis, Female, Pancreas, business, Peptides
Abstract

Summary In 403 patients suspected of having pancreatic cancer, we prospectively studied a combination assay of various serum tumor markers: CA19-9, DUPAN2, tissue polypeptide antigen, elastase 1, γ-glutamyltranspepti-dase, lactate dehydrogenase, lipase, amylase, and alkaline phosphatase. The diagnostic value of each marker was compared with a multivariate analysis (computer-aided multivariate and pattern analysis system for pancreatic cancer examine-1: CAMPAS-PX1). Pancreatic cancer was subsequently identified in 47 patients. CAM-PAS-PX1 had higher negative in health and positive predictability than those of each marker used alone in the diagnosis of pancreatic cancer. CAMPAS-PX1 proved the most effective marker for diagnosing pancreatic cancer, but in terms of its codbenefit ration CAMPAS-PX1 was not superior to CA19-9 used alone. In this prospective trial, we experienced poor generalizability in the statistical models (CAMPAS-PX1). We believe that selection bias was present in samples used for model building. Based on this study a new model has been designed.

Published
1994

6. (1) Diagnosis of benign papillary lesions by cholangiography and biliary pressure study

Author

K. Ono, Itsuo Miyazaki, Yoshiro Matsumoto, Toshimichi Nakayama, Masatsugu Nakajima, Matsuro Shimano, Yukihiro Tsuchiya, Kotaro Uchida, Yuzo Akasaka, Minoru Kizu, Hisoshi Sugiura, Koichi Miwa, Takeshi Takasaki, Katsuji Hayashi, Masao Ohto, Nobuyoshi Kuno, Tadahiro Takada, Makoto Sakamoto, and Mitsuhiro Akashi

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gastroenterology, Hepatology, Colorectal surgery, Cholangiography, Surgical oncology, Internal medicine, Medicine, Radiology, business, Abdominal surgery
Published
1976
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7. Progression of radiological changes in relapsing and chronic pancreatitis

Author

Katsuhiko Fujiwara, Kumiko Kurimoto, Tatsuzo Kasugai, Kenji Tanehiro, and Nobuyoshi Kuno

Subjects
Male, Pathology, medicine.medical_specialty, Time Factors, Disease, Gastroenterology, Recurrence, Internal medicine, Humans, Medicine, skin and connective tissue diseases, Pancreas, Aged, Cholangiopancreatography, Endoscopic Retrograde, Pancreatic duct, Endoscopic retrograde cholangiopancreatography, Hepatology, medicine.diagnostic_test, business.industry, Gallstones, Middle Aged, medicine.disease, Alcoholism, medicine.anatomical_structure, Pancreatitis, Radiological weapon, Chronic Disease, Acute pancreatitis, Female, sense organs, business
Abstract

Progression of radiological changes was noted in 19 (22.1%) of 86 cases of relapsing or chronic pancreatitis followed by serial pancreatograms. The initial feature of chronic pancreatitis was focal minimal pancreatitis, characterized by an irregular dilatation of several side branches on the pancreatogram. Some patients with focal minimal pancreatitis demonstrated progression of the extent and severity of changes only in side branches while others progressed further to moderate or advanced chronic pancreatitis showing changes in the main pancreatic duct. Most of the progressive cases were alcoholic, and some showed progression to advanced pancreatitis within 4 years. Rapid progression of radiological changes was associated with relapses of acute pancreatitis. No remarkable changes were observed in many non-alcoholic patients, whereas some cases complicated with gallstones showed progression of disease in the side branches during a follow-up period of 3–7 years.

Published
1989
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8. Abstracts of selected papers presented at the 29th annual meeting of the japanese society of gastroenterology

Author

Kyuichi Tanikawa, Eizo Okamoto, Kenji Hirai, Yasuo Majima, Morio Sato, Ryusaku Yamada, Masaaki Ebara, Masao Ohto, Naoki Yamanaka, Kazuhiro Hirohashi, Hiroaki Kinoshita, Toshio Yamamoto, Yasuyuki Ohta, Yoshihide Sakagami, Yasuhiro Mizoguchi, Yukihiko Adachi, K. Kamisaka, H. Kurisu, Masahiro Nakai, Ryuji Mizumoto, Tomofumi Morita, Tadasu Tsujii, Yohei Fukumoto, Kiwamu Okita, Kenzo Kobayashi, Masaki Kitajim, Mitsuru Aono, Motoyuki Moriga, Hajime Kuwayama, Y. Ikeda, M. Kitajima, K. Ogino, S. Oka, Makoto Itoh, Tadahisa Miyamoto, Hidenobu Watanabe, Shozo Baba, Tsuyoshi Kida, Tsuyoshi Tajima, Masahiro Igarashi, Tomoe Katumata, Takeyasu Suda, Terukazu Muto, T. Muto, M. Adachi, Takachika Ozawa, Isamu Kino, Tomio Narisawa, Hirofumi Koyama, Kunio Okajima, Masayoshi Mai, Kimiya Takeshita, Minoru Kawaguchi, Rintaro Narisawa, Shingo Ishiguro, Motohisa Takami, Yasuo Idezuki, Kensho Sanjo, Seigo Kitano, Hajime Ikeda, Atsushi Toyonaga, Morio Masaki, Toshiyuki Arakawa, Takeshi Miwa, Teruaki Aoki, Michio Hongo, Shigeru Harasawa, Masaki Inoue, Kazuhiko Watanabe, Sci Shiraha, Hideo Yamada, Shoichi Yamagata, Takaaki Takebe, Tetsuo Hayakawa, Ryo Myoen, Koji Ochi, Tsukasa Itabashi, Masao Yagi, Jo Ariyama, Tadahiro Takada, Nobuyoshi Kuno, Kenji Tanehiro, Kazuhiro Satoh, Seikoh Shimaguchi, Kenji Yamao, Saburo Nakazawa, Takaaki Ikari, Joe Ariyama, Eishi Miyashita, Seiki Matsuno, Masanobu Goto, Masahiko Miyata, Toshihide Imaizumi, Fujio Hanyu, Tadao Manabe, Takashi Suzuki, Tetsuo Ohta, Takukazu Nagakawa, Junichi Kamiya, and Yuji Nimura

Subjects
medicine.medical_specialty, Adenoma, business.industry, medicine.medical_treatment, General surgery, Gastroenterology, Hepatology, medicine.disease, Colorectal surgery, Lower esophageal sphincter pressure, Esophageal varices, Surgical oncology, Internal medicine, medicine, Percutaneous ethanol injection, business, Abdominal surgery
Published
1988
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9. Proceedings of the 20th autumn meeting from October 19 20, and 21, 1978—Gifu, Japan

Author

Hideo Hiratsuka, Kōji Gochō, Mikio Inoue, Ichiro Yoshida, Kiyoshi Kawakami, Akihiro Munakata, Tsuneo Takahashi, Tsutomu Kamei, T. Shimoyama, K. Tamura, H. Sasaki, K. Nagasako, Shiro Hosoda, Tadao Bamba, Ryonosuke Yoshimura, Takeyuki Monna, Masaaki Kanayama, Yoshitane Kosaka, Yukihiko Tameda, Shujiro Takase, Hiromichi Nakaya, Takehiko Inagaki, Koichi Shibasaki, Minoru Haga, Takashi Ando, Yukihiko Adachi, Yasuyuki Ohta, Akihiko Goto, Atsuyoshi Onitsuka, Nobuyoshi Kuno, Kazuo Tarao, Masatomo Yoshioka, Toru Isoyama, Shoetsu Tamakuma, Hiroshi Shimada, Takukazu Nagakawa, Wataru Takahashi, Toshio Sato, Hiroshi Tanimura, Yorinori Hikasa, Takeshi Oohara, Yasumasa Baba, Takao Takegoshi, Tadashi Yarita, Shigeru Suzuki, Hitoshi Murakami, Yukinori Okazaki, Kiyoshi Fujita, Yoshikatsu Kubota, Keishi Fukumoto, Shigeru Asaki, Jun Yamagata, Hitoshi Hidano, Saburo Nakazawa, H. Nishimata, Shigeaki Yoshida, Katsunori Saigenji, Atsuo Gotoh, Keiichi Yoshino, Yoshinori Yamada, Hideo Atari, Schunsuke Murai, Kazuo Mizushima, Kiyoshi Okamura, Mitsugi Sugiyama, Nobuhiro Sato, Motoharu Kondo, Toshikazu Yoshikawa, Takenori Hashimoto, Atsushi Toyonaga, Yuzo Akasaka, Susumu Kawamura, Sakae Aoyama, Yoshikiyo Sajima, Yoshio Mishima, Yoshiaki Horie, Makoto Miyaji, Makoto Ito, Shozo Baba, Yoshihiko Takada, Takeyoshi Imaeda, Kouji Sugiyama, Choichiro Kido, Tokiko Endo, Toshihiko Ozaki, Fumihiro Ichida, Morimichi Fukuda, Hitoshi Asai, Tsugio Kitamura, Sachiko Tanaka, Yuji Itai, Guio Uchiyama, Yukio Tateno, Eizo Kimoto, Ehi Karasawa, Masao Ohto, Akira Wakabayashi, Fumiaki Ikegami, Noriyuki Moriyama, Tatsuya Yamada, and Masatoshi Makuuchi

Subjects
medicine.medical_specialty, business.industry, Surgical oncology, Internal medicine, General surgery, Gastroenterology, Medicine, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1979
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10. Manometric endoscopic retrograde pancreatocholangiography

Author

Tatsuzo Kasugai, Nobuyoshi Kuno, and Minoru Kizu

Subjects
Gastric Fistula, medicine.medical_specialty, Manometry, Physiology, Liver Abscess, Mixed type, Pancreatic Fistula, Filling defect, Cholelithiasis, Internal medicine, Methods, Pressure, medicine, Humans, Pancreas, Grading (tumors), Pancreatic duct, business.industry, Liver Neoplasms, Gastroenterology, Pancreatic Diseases, Endoscopy, General Medicine, Hepatology, medicine.disease, Surgery, Pancreatic Neoplasms, Stenosis, Contrast medium, medicine.anatomical_structure, Pancreatitis, Amylases, Radiology, Pancreatic Cyst, business, Cholangiography
Abstract

A manometer has been developed to permit measurement and control of the injection pressure of the contrast medium in endoscopic pancreatocholangiography (EPCG). Using this method we have retained the precision of the investigation but have avoided pancreatic damage caused by excessive pressure. The findings of pancreatic carcinoma in EPCG were characterized by stenosis and obstruction of the main pancreatic duct and, sometimes, by a peripheral filling defect. Obstructed type, stenosed type, pancreatic-field-defect type, and mixed type were encountered in that order of frequency. 28 of 29 proved cases of pancreatic carcinoma were correctly diagnosed preoperatively by EPCG. There were two possible false positive diagnoses. Chronic pancreatitis was classified into three groups: minimal, moderate, and advanced pancreatitis, according to a grading of findings in EPCG. The main findings of minimal and moderate pancreatitis were “pancreatectasis.” There was a close correlation between histological and EPCG grading of chronic pancreatitis. EPCG is now one of the most reliable procedures for the detection of diseases of the pancreatic and biliary systems.

Published
1974
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11. Proceedings of the 69th General Meeting from April 11–13, 1983-Osaka, Japan

Author

Yoshihiro Baba, Kunio Nagata, Yoshihisa Tsukada, Rintaro Narisawa, Akira Honma, Shinichi Hirose, Mineo Tomizawa, Toshihiko Ozaki, Fumihiro Ichida, Kenji Tanehiro, Nobuyoshi Kuno, Kumiko Kurimoto, Tetsuo Yokota, Tomoyuki Kano, Tatsuzo Kasugai, Kazuya Ueno, Katsuhide Shimakura, Akira Kakita, Masaaki Kambayashi, Tsuyoshi Takahashi, Eisei Sasaki, Yoichi Kasai, Toshihisa Takahashi, S. Shimaguchi, J. Ariyama, Masatoshi Sumida, Yukihiro Tsuchiya, Masao Ohto, Fumio Asagami, Tadasu Fuji, Norimasa Okabe, Kenji Sakurai, Shuichi Miyakawa, Yuji Horiguchi, Hiroshi Nakano, Yuji Nimura, N. Hayakawa, H. Hasegawa, J. Kamiya, S. Maeda, Y. Iyomasa, Yoshiro Matsumoto, Katsuhiko Sugahara, T. Ida, R. Mashimo, Shu Kou Wen, H. Fujii, S. Wakashiro, G. Isowa, S. Itoh, T. Yamakawa, Hidenori Udaka, Hideyuki Miyamoto, Toshikazu Tamura, Tsutomu Hirai, Osamu Okamura, Nobuhiko Komi, Nobuo Yoshioka, Yoshio Kawamura, Takahiko Kojima, Hitoshi Hachiya, Nobuyoshi Okumura, Kunihiko Suzuki, Toshiyuki Suzuki, Sadasuke Suzuki, Norishige Ozeki, Kazuo Goto, Shigehiro Shiraki, Toshihiko Takeuchi, Atsumasa Yamaguchi, Tadashi Shibue, Yukimitsu Kawaura, Takashi Iwa, Isao Takeda, Satoshi Nakano, Tomoko Kobayashi, Hideo Harada, Tokio Wakabayashi, Norio Sawabu, Yasuo Naito, Saburo Nakazawa, Tomoaki Isawa, Ikuo Tabata, Yuichi Sasaki, Hideaki Yamada, Shunichi Tatsumi, Kenzo Kobayashi, Eitaro Suzuki, Eizo Okamoto, Masakatsu Matsukawa, Toshio Nakanishi, Hiroiku Kawakami, Sotaro Fujimoto, Masatsugu Nakajima, Junichi Sugihara, Yoichi Saitoh, Takashi Matsushiro, Hideyuki Nagashima, Kyoji Yamamoto, Ryuji Nakamura, Junichi Tanaka, Fumito Shimizu, Takashi Toshima, Tuneo Hariu, Takukazu Nagakawa, Noriyoshi Suzuki, Wataru Takahashi, Ikunoshin Uematsu, Toshio Sato, K. Egami, T. Tajiri, N. Aoki, K. Yamaguchi, H. Yamakawa, A. Watanabe, M. Yano, S. Hatta, M. Yoshioka, M. Miki, A. Shirota, Koji Morimoto, Masato Furukawa, Toshinori Nakata, Ryuhei Yamada, Shinichiro Ito, Shigeru Maeda, Toshinori Morinaga, Makota Tanigawa, Toshiyuki Fujio, Hiroshi Inui, Hiroaki Kinoshita, Osamu Yamasaki, Eiichi Nagata, Kazuhiro Hirohashi, null Sakai, Tadahiro Takada, Hideki Yasuda, Makoto Shishikura, Katsuhiro Uchiyama, Yoshifumi Ogura, Ryuji Mizumoto, Kazuomi Nakazawa, Shunichi Sato, Isamu Kaito, Hiroshi Suzuki, Masao Ohtsuki, Yoshio Goto, M. Nomoto, K. Yunoue, K. Soga, F. Ichida, Y. Koike, K. Kiyosawa, Y. Akahane, K. Kamijyo, Y. Suzuki, S. Yamamura, T. Komatsu, A. Nagata, S. Furuta, Shigeki Hayashi, Yasuhiko Ohta, Kenji Fujiwara, Yuzuru Sato, Itsuro Ogata, Katsuyoshi Takatsuki, Shunji Mishiro, Hiroshi Oka, Masaru Furube, Nobuo Yamada, Hisao Shibata, Akitaka Shibuya, Eishi Hijikata, Shigenobu Kokubu, Kohdo Ishii, Haruya Okabe, Kenichi Sasaki, Akira Takada, Jugoro Takeuchi, Yasuyuki Ohta, Tadashi Tsujii, Fumiaki Ikegame, Masashi Unoura, Akihiko Furusawa, Nobuyoshi Tanaka, Yasuhiro Kato, Kenichi Kobayashi, Nobu Hattori, Yukihiko Tameda, Satoshi Kakiuchi, Yoshitane Kosaka, Shigeyoshi Harihara, Sukeo Yamamoto, Gotaro Yamada, Hideo Nagashima, Morikazu Onji, Yoshimasa Yamashita, Norio Horiike, Hirohiko Abe, Kazuhiko Hino, Masaru Kojima, Kazunori Noguchi, Hiromu Ueda, Tomoki Aritaka, Naoto Maruyama, Hitoshi Motoori, Kazuaki Yamauchi, Hiroshi Setoyama, Michio Sata, Yasuhiko Kubo, Kyuichi Tanikawa, Tatsuo Munehisa, Keisuke Nakata, Kenzo Kono, Toyoichi Muro, Akira Sato, Ryuji Furukawa, Nobuko Ishii, Yukio Kusumoto, Toshihiko Koji, Shigenobu Nagataki, Norio Nakao, Kohi Miura, Y. Sato, Y. Ohta, I. Ogata, S. Hayashi, K. Fujiwara, H. Oka, S. Furui, M. Iio, Kenji Ikeda, Eiji Oyake, Kazuo Takeuchi, Hiromitsu Kumada, Masao Nakajima, Akira Yoshiba, Masahiro Irimoto, Toshio Kobayashi, Morio Satoh, Ryusaku Yamada, Haruki Nakatsuka, Kenji Hirai, Masanobu Kumagai, Genjiro Yamaguchi, Masatoshi Tanaka, Masanobu Abe, Keijiro Ando, Yasushi Shingai, Kiwamu Okita, Tadayoshi Takemoto, Kazuo Tarao, Kenichiro Iwamura, Kenji Soga, Minoru Nomoto, Hitoshi Takagi, Takafumi Ichida, Shunsaku Higashi, Takashi Noguchi, Takashi Kanematsu, Kenji Takenaka, Takashi Matsumata, Takashi Sonoda, Toshiya Furuta, Keizo Sugimachi, Kiyoshi Inokuchi, Susumu Yamasaki, Hiroshi Hasegawa, Masatoshi Makuuchi, Yoshimi Nakanishi, Hidekazu Sano, Tetsuro Konno, Fumio Sano, Toshiharu Tsuzuki, Shuhei Iida, Naoki Yamanaka, Keiji Kuwata, Akihiro Toyosaka, Nobutaka Tanaka, Shiro Fujiwara, Hajime Yamazaki, Katsuji Sakai, Tokio Ono, Hiroaki Yamada, Masahiro Tada, Hitoshi Asakura, Kensuke Kobayashi, Tetsuo Morishita, Masaharu Tsuchiya, Nobutaka Sato, Hideo Hiratsuka, N. Ueda, and K. Harada

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, Library science, Medicine, business
Published
1984
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12. Symposium (III): Clinical aspects of the duodenal diverticula

Author

Y. Mizuno, Yoshio Hatta, M. Morita, Masafumi Kobayashi, Y. Kajiyama, Fumio Sugata, Tsuyoshi Kihara, Nobuyoshi Kuno, Kazuo Mitsusada, Chikazumi Kuroda, Toshimichi Inoue, Shinji Miyagi, Masayuki Iwasaki, Yoshikazu Matsuzawa, S. Nakano, Takeo Takeda, Yasuhide Ota, Minoru Kizu, and Seiichi Hasegawa

Subjects
medicine.medical_specialty, Surgical oncology, business.industry, Internal medicine, General surgery, Gastroenterology, medicine, Hepatology, business, Colorectal surgery, Abdominal surgery
Published
1973
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13. Endoscopic Pancreatocholangiography

Author

Minoru Kizu, Tatsuzo Kasugai, Seibi Kobayashi, Nobuyoshi Kuno, and Kazuhiko Hattori

Subjects
medicine.medical_specialty, Liver tumor, Hepatology, Common bile duct, business.industry, Gallbladder, Gastroenterology, medicine.disease, medicine.anatomical_structure, Text mining, medicine, Carcinoma, Pancreatitis, Radiology, Pancreas, business, Pathological
Abstract

Endoscopic pancreatocholangiography was successfully performed in 200 (74.1%) of 270 cases, obtaining 45 endoscopic pancreatocholangiograms, 133 endoscopic pancreatograms, and 22 endoscopic cholangiograms. Fourteen neoplastic lesions including nine of carcinoma of the pancreas, two of carcinoma of the common bile duct, and one each of carcinoma of the gallbladder, peripancreatic tumor, and multicentric liver tumor were correctly diagnosed while no other investigational procedure was able to clarify the diagnosis. This was also the case in eight instances of cholelithiasis, five of choledocholithiasis, and one of cholecystocholedocholithiasis. Chronic pancreatitis was confirmed in 55 cases. The abnormalities on endoscopic pancreatograms are very variable in this condition, but the procedure may well prove valuable in evaluating the severity of chronic pancreatitis.

Published
1972
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14. Fiberduodenoscopy: analysis of 353 examinations

Author

I. Aoki, Seibi Kobayashi, Tatsuzo Kasugai, Minoru Kizu, and Nobuyoshi Kuno

Subjects
Endoscopes, Male, Pathology, medicine.medical_specialty, medicine.diagnostic_test, Duodenum, business.industry, Biopsy, Gastroenterology, Endoscopy, Early carcinoma, Major duodenal papilla, medicine.anatomical_structure, Duodenal Ulcer, Duodenal bulb, Methods, Humans, Medicine, Female, Radiology, Nuclear Medicine and imaging, business, Gastrointestinal Neoplasms
Abstract

Endoscopic examination of the duodenum was successful in 95.7% of 353 cases enploying the Machida FDS-L and the Olympus JF instruments. In the duodenal bulb, active ulcer crater and scar were differentiated. Biopsy specimens were readily obtained, including that from an early carcinoma of the papilla. Pancreatography was accomplished in 12 cases.

Published
1971
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15. Endoscopic Pancreatocholangiography

Author

Nobuyoshi Kuno, Tatsuzo Kasugai, Kazuhiko Hattori, and Seibi Kobayashi

Subjects
Pancreatic duct, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gallbladder, Gastroenterology, medicine.disease, medicine.anatomical_structure, Cholangiography, Amylasemia, Duodenum, Fiberoptic endoscope, Medicine, Pancreatitis, Radiology, business
Abstract

Endoscopic pancreatocholangiography was successfully performed in 61.5% of 174 attempted cases (83.3% of the most recent 108 attempts). The normal pancreatic duct has a variable configuration, and injection of a progressively increasing volume of contrast material results in opacification of duct branches (primary, secondary, and tertiary), fine pancreatic ducts, and, finally, the acini. Greater degrees of opacification are associated with a higher incidence of amylasemia, but not overt clinical pancreatitis. In 32.4% of cases, a separate opening of the duct of Santorini into the duodenum was found. The pancreatic and common bile ducts terminated in a common channel in 11 of 12 cases where both ducts were visualized. The gallbladder was opacified in 30 of 38 endoscopic cholangiograms. Pancreatography and cholangiography performed through a fiberoptic endoscope are safe and practical diagnostic techniques.

Published
1972
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16. Endoscopic pancreatocholangiography with special reference to manometric method

Author

Nobuyoshi Kuno, Minoru Kizu, and Tatsuzo Kasugai

Subjects
Mesothelioma, Information retrieval, business.industry, Manometry, Biliary Tract Diseases, Pancreatic Ducts, Pancreatic Diseases, Endoscopy, General Medicine, Dysgerminoma, Catheterization, Pancreatic Neoplasms, Text mining, Pancreatitis, Chronic Disease, Methods, Medicine, Humans, Autopsy, Retroperitoneal Neoplasms, Neoplasm Metastasis, Pancreatic Cyst, business, Cholangiography
Published
1973

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