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1. Development of a portable device for the viscosity measurement of non-Newtonian fluids based on pressurized laminar flow.

Author

Nobuaki IKEDA, Daisuke FUNAYAMA, Satoko FUJIOKA, and Koichi TERASAKA

Subjects
NEWTONIAN fluids, LAMINAR flow, STRAINS & stresses (Mechanics), SHEARING force, MEASUREMENT of viscosity, NON-Newtonian fluids, NON-Newtonian flow (Fluid dynamics)
Abstract

In this study, we focus on developing a simple and flexible rheometer based on pressurized laminar flow. The developed device uses pressure- and flow-rate measurements to calculate the shear rates and shear stresses on the pipe walls, based on the Herschel–Bulkley model. The rotational viscometer, an existing measurement device, struggles with measuring systems that contain large solid particles because of its narrow-gap assumption. Moreover, conventional fluid-delivery measurement devices require large pumps and multiple sensors, necessitating large-scale and expensive setups. In contrast, our device, comprising only a flow meter and a pressure gauge, is simple and can measure various fluids by changing the connected pipe’s diameter. We employed glycerin as a Newtonian single-phase fluid, polymer aqueous solutions as non-Newtonian single-phase fluids, and multiphase food fluids (low-oil-type mayonnaise and ketchup) to compare the rheological analysis data obtained from both the rotational viscometer and our device. Both devices delivered consistent results for Newtonian fluids and non-Newtonian fluids exhibiting shear-thinning behavior. Upon comparing the actual measured shear stresses and shear rates for single-phase fluids, the discrepancy between the results from our device and those from the rotational viscometer was up to ~6.6%, whereas discrepancies of 12.1% and 17.6% were observed for mayonnaise and ketchup, respectively. For the single-phase fluids, the measurement results delivered by both devices were similar; however, discrepancies were observed for the multiphase fluids. These discrepancies are attributable to the accumulated shear stress applied to the fluid and slippage on the tube wall, suggesting that our device enables simple and flexible rheological measurements. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Clinical significance of serum levels of anti‐transcriptional intermediary factor 1‐γ antibody in patients with dermatomyositis

Author

Nobuaki Ikeda, Miwa Kanaoka, Tomoya Watanabe, Michiko Aihara, Yukie Yamaguchi, Asami Akita, and Yasushi Ototake

Subjects
Adult, Male, medicine.medical_specialty, Dermatology, Malignancy, Severity of Illness Index, Gastroenterology, Dermatomyositis, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Japan, Neoplasms, Internal medicine, medicine, Humans, Clinical significance, Creatine Kinase, Myositis, Aged, Autoantibodies, Aged, 80 and over, Mediation Analysis, biology, business.industry, Autoantibody, General Medicine, Middle Aged, medicine.disease, Titer, 030220 oncology & carcinogenesis, Concomitant, biology.protein, Female, Antibody, Lung Diseases, Interstitial, business, Transcription Factors
Abstract

Dermatomyositis (DM) is an autoimmune inflammatory disease characterized by skin eruptions and myositis. Anti-transcriptional intermediary factor 1-γ antibody (anti-TIF1-γ Ab) is one of the most frequently detected myositis-specific autoantibodies and adults positive for anti-TIF1-γ have markedly higher rates of malignancy. Our aim was to determine the clinical associations of anti-TIF1-γ levels in 31 Japanese adult DM patients positive for anti-TIF1-γ. We determined associations between the anti-TIF1-γ index and patient characteristics and disease severities. Sixteen patients with anti-TIF1-γ Ab had concomitant malignancies. A mild positive correlation was found between the levels of serum creatine phosphokinase at the first visit and anti-TIF1-γ levels. In contrast, there was no significant difference in the anti-TIF1-γ Ab index between patients with and without malignancy. Dysphagia tended to be observed in patients with malignancy. On sequential analysis, anti-TIF1-γ levels in patients without malignancy were lower or turned negative after treatment for DM. Ab titers tended to be sustained in patients with stage IV malignancies. Interestingly, a re-increase in the Ab titer was observed on recurrence of malignancy or increase in DM activity. Four patients were completely cured of their malignancies, and anti-TIF1-γ levels in three patients turned negative with the loss of DM activity. These data suggest that higher anti-TIF1-γ titers may not directly indicate the presence of malignancy. Nevertheless, longitudinal changes in the anti-TIF1-γ index in individual patients may partially reflect activities of both DM and malignancy.

Published
2020
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3. Varied responses to and efficacies of hydroxychloroquine treatment according to cutaneous lupus erythematosus subtypes in Japanese patients

Author

Asami Akita, Yasushi Ototake, Nobuaki Ikeda, Yukie Yamaguchi, Michiko Aihara, and Miwa Kanaoka

Subjects
Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Dermatology, Drug Administration Schedule, 030207 dermatology & venereal diseases, 03 medical and health sciences, Therapeutic approach, 0302 clinical medicine, Japan, Lupus Erythematosus, Cutaneous, medicine, Humans, skin and connective tissue diseases, Retrospective Studies, Skin, High rate, Dose-Response Relationship, Drug, business.industry, fungi, Retrospective cohort study, Hydroxychloroquine, General Medicine, Middle Aged, Treatment Outcome, Immunosuppressive drug, 030220 oncology & carcinogenesis, Concomitant, Cutaneous Lupus Erythematosus, Drug Therapy, Combination, Female, business, Immunosuppressive Agents, medicine.drug
Abstract

Hydroxychloroquine is recommended as the first-line systemic treatment for cutaneous lupus erythematosus (CLE) in Western countries, and it was approved in Japan in 2016. However, the efficacy of hydroxychloroquine in various cutaneous lupus erythematosus subtypes in Japanese patients has not been elucidated to date. Therefore, we investigated the efficacy of hydroxychloroquine for the treatment of cutaneous manifestations according to CLE subtypes in Japanese patients. We enrolled 35 patients (29 diagnosed with systemic lupus erythematosus and six with CLE) in this retrospective study. We analyzed the efficacy of hydroxychloroquine for the treatment of cutaneous manifestations according to cutaneous lupus erythematosus subtypes, time to the first skin improvement, as well as effects on laboratory data and reduction of concomitant immunosuppressive drug administration at 16 and 32 weeks of therapy. Complete improvement was observed at high rates for acute CLE (ACLE); however, partial or non-improvement rates were higher for chronic CLE (CCLE) at 16 weeks. Several patients with alopecia without scarring achieved complete improvement at 32 weeks. CCLE tended to take more time to improve than ACLE. Overall, hydroxychloroquine was highly effective for skin: 87% of patients had at least some beneficial response at 16 weeks. Nevertheless, there were wide variations in complete improvement rates and duration for improvement among CLE subtypes. Our findings suggest that a therapeutic approach considering the subtypes of CLE will improve its management.

Published
2019
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5. A numerical analysis to evaluate the emulsifying activity of pasteurized egg yolk

Author

Nobuaki Ikeda and Sakai Shunji

Subjects
food.ingredient, Chemistry, General Chemical Engineering, Pasteurization, General Chemistry, Soybean oil, law.invention, Surface tension, food, law, Oil droplet, Yolk, embryonic structures, Particle-size distribution, Emulsion, Food science, Solubility, Food Science
Abstract

Egg yolk is commonly used as an emulsifier in foods such as mayonnaise. However, its emulsifying activity is affected by different pasteurization conditions. The effect of pasteurization on the emulsifying activity of egg yolk has not been elucidated. Therefore, it is necessary to develop a method to accurately predict the emulsifying activity of egg yolk. In this study, we demonstrated that the interfacial tension between egg yolk and soybean oil under different treatment conditions could be measured and analyzed using a new method. We measured the physical properties, including solubility, particle size distribution, and interfacial tension, of egg yolk after different heat treatments. In addition, we calculated the correlation between these parameters and the oil droplet size of the emulsion to investigate the relationship between each parameter and the emulsifying activity of egg yolk. We found that the interfacial tension was a more accurate predictor of the emulsifying activity than other parameters indicating protein denaturation. Our method could be employed to identify the most optimum pasteurization condition for egg yolk at an industrial scale.

Published
2022
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6. A case of toxic epidermal necrolysis associated with apalutamide administration

Author

Yukie Yamaguchi, Tomoya Watanabe, Saki Takahashi, Nobuaki Ikeda, Yuko Watanabe, Yuto Mizuno, Michiko Aihara, and Nobuko Sagawa

Subjects
chemistry.chemical_compound, Anti-ss-a antibody, chemistry, Lymphocyte transformation, business.industry, Apalutamide, medicine, Immunology and Allergy, Dermatology, Pharmacology, medicine.disease, business, Toxic epidermal necrolysis
Published
2020
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7. Clinically amyopathic dermatomyositis with anti-transcriptional intermediary factor 1-γ autoantibody positivity

Author

Michiko Aihara, Tomoya Watanabe, Nobuaki Ikeda, Miwa Kanaoka, Asami Akita, Yasushi Ototake, and Yukie Yamaguchi

Subjects
Aged, 80 and over, Male, Transcriptional intermediary factor 1, business.industry, Autoantibody, Middle Aged, Skin Diseases, Dermatomyositis, Amyopathic dermatomyositis, Asian People, Rheumatology, Case-Control Studies, Neoplasms, Immunology, Prevalence, Humans, Medicine, Female, Pharmacology (medical), Lung Diseases, Interstitial, business, Aged, Autoantibodies, Transcription Factors
Published
2020
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8. Analysis of dermatomyositis-specific autoantibodies and clinical characteristics in Japanese patients

Author

Yukie Yamaguchi, Nobuaki Ikeda, Kazuo Takahashi, Zenro Ikezawa, Mai Inasaka, and Masataka Kuwana

Subjects
Internal malignancy, Pathology, medicine.medical_specialty, biology, business.industry, Autoantibody, Interstitial lung disease, Dermatology, General Medicine, Disease, Dermatomyositis, medicine.disease, Malignancy, Gastroenterology, Internal medicine, medicine, biology.protein, In patient, Antibody, business
Abstract

Dermatomyositis (DM) is an idiopathic systemic inflammatory disease that is often accompanied by interstitial lung disease (ILD) or internal malignancy. New autoantibodies, anti-clinically amyopathic dermatomyositis 140 (anti-CADM-140) antibody (Ab) and anti-155/140 Ab, as well as anti-aminoacyl-tRNA synthetase (anti-ARS) Ab and anti-Mi-2 Ab, have been discovered and their utility indicated. However, the association between these autoantibodies and the clinical characteristics of DM is not fully understood, and it is unclear whether anti-155/140 Ab is "specific" to DM patients with internal malignancy. Therefore, we analyzed 55 DM patients and 18 non-DM patients with malignancy to evaluate the clinical characteristics, especially skin manifestations, in association with DM-specific autoantibodies detected by immunoprecipitation. Six patients (11%) had anti-CADM-140 Ab, nine (16%) had anti-155/140 Ab, eight (15%) had anti-ARS Ab and six (11%) had anti-Mi-2 Ab. The frequency of DM patients positive for any type of autoantibody was 53%. Among the 20 DM patients with ILD, three (15%) had both anti-CADM-140 Ab and rapidly progressive ILD, and required intensive therapy (P < 0.05). ILD found in anti-ARS Ab-positive patients did not progress rapidly. The prevalence of muscle involvement in patients with anti-CADM-140 Ab was 83%. Among the 18 DM patients with internal malignancy, four (22%) had anti-155/140 Ab, and internal malignancy was found in four cases (44%) of nine anti-155/140 Ab-positive patients. None of the non-DM patients with malignancy were positive for anti-155/140 Ab. In conclusion, the results of the present study indicate that anti-155/140 Ab is specific to DM patients with internal malignancy and that we may be able to predict prognosis of ILD and the presence of malignancy to some extent, suggesting that examination of autoantibodies in DM patients is clinically very useful. However, further investigation is needed because several findings differ from those of previous reports.

Published
2011
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9. A contact investigation of the transmission of Mycobacterium tuberculosis from a nurse working in a newborn nursery and maternity ward

Author

Ikeda T, Nobuaki Ikeda, Yumiko Ikegami, Ken Miyanomae, Takuya Kurasawa, Yoshiaki Yamamoto, Kenji Kishida, Takashi Taniguchi, Atsuo Sato, and Hitoshi Ohno

Subjects
Adult, Male, Microbiology (medical), medicine.medical_specialty, Pediatrics, Tuberculosis, Health Personnel, Mothers, Nurses, Tuberculin, Infectious Disease Transmission, Professional-to-Patient, QuantiFERON, Mycobacterium tuberculosis, Japan, Nursing, Epidemiology, medicine, Humans, Infection control, Pharmacology (medical), Child, biology, Tuberculin Test, business.industry, Transmission (medicine), Public health, Infant, Newborn, Infant, Middle Aged, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Infectious Diseases, Child, Preschool, Female, Contact Tracing, Nurseries, Infant, business
Abstract

A nurse working in a newborn nursery and maternity ward developed 3+ smear-positive lung tuberculosis. The hospital infection control committee, in collaboration with the local public health and welfare center, conducted a contact investigation. The infection period was defined as April to August 2006. The investigation included 109 infant and mother pairs, 28 children aged under 10 years and their guardians, 62 coworkers, and 63 household visitors to the ward. Tuberculosis infection in infants and children aged under 5 years was primarily determined by tuberculin skin test (TST), while subjects aged 5 years or more were tested using QuantiFERON-TB Gold (QFT). The first investigation, in August 2006, was conducted in all subjects, and the second investigation, in October 2006, targeted selected subjects. No infants were TST-positive. Two children aged 1 year or under, vaccinated with bacillus Calmette-Guérin, were positive for TST, as determined by the criteria of the Japan Anti-Tuberculosis Association; however, other tests for tuberculosis were negative. Of the 13 QFT-positive adult subjects, 1 mother and 2 coworkers could have become infected with Mycobacterium tuberculosis through exposure to the index nurse. Fifty-four infants and 6 children underwent "window-period" prophylaxis, and 4 adults completed 6-month prophylactic treatment with isoniazid. To date, no secondary cases of tuberculosis disease have occurred.

Published
2008
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10. Analysis of dermatomyositis-specific autoantibodies and clinical characteristics in Japanese patients

Author

Nobuaki, Ikeda, Kazuo, Takahashi, Yukie, Yamaguchi, Mai, Inasaka, Masataka, Kuwana, and Zenro, Ikezawa

Subjects
Adult, Male, Middle Aged, Dermatomyositis, Amino Acyl-tRNA Synthetases, Asian People, Japan, Antibody Specificity, Neoplasms, Humans, Intercellular Signaling Peptides and Proteins, Female, Lung Diseases, Interstitial, Peptides, Aged, Autoantibodies
Abstract

Dermatomyositis (DM) is an idiopathic systemic inflammatory disease that is often accompanied by interstitial lung disease (ILD) or internal malignancy. New autoantibodies, anti-clinically amyopathic dermatomyositis 140 (anti-CADM-140) antibody (Ab) and anti-155/140 Ab, as well as anti-aminoacyl-tRNA synthetase (anti-ARS) Ab and anti-Mi-2 Ab, have been discovered and their utility indicated. However, the association between these autoantibodies and the clinical characteristics of DM is not fully understood, and it is unclear whether anti-155/140 Ab is "specific" to DM patients with internal malignancy. Therefore, we analyzed 55 DM patients and 18 non-DM patients with malignancy to evaluate the clinical characteristics, especially skin manifestations, in association with DM-specific autoantibodies detected by immunoprecipitation. Six patients (11%) had anti-CADM-140 Ab, nine (16%) had anti-155/140 Ab, eight (15%) had anti-ARS Ab and six (11%) had anti-Mi-2 Ab. The frequency of DM patients positive for any type of autoantibody was 53%. Among the 20 DM patients with ILD, three (15%) had both anti-CADM-140 Ab and rapidly progressive ILD, and required intensive therapy (P0.05). ILD found in anti-ARS Ab-positive patients did not progress rapidly. The prevalence of muscle involvement in patients with anti-CADM-140 Ab was 83%. Among the 18 DM patients with internal malignancy, four (22%) had anti-155/140 Ab, and internal malignancy was found in four cases (44%) of nine anti-155/140 Ab-positive patients. None of the non-DM patients with malignancy were positive for anti-155/140 Ab. In conclusion, the results of the present study indicate that anti-155/140 Ab is specific to DM patients with internal malignancy and that we may be able to predict prognosis of ILD and the presence of malignancy to some extent, suggesting that examination of autoantibodies in DM patients is clinically very useful. However, further investigation is needed because several findings differ from those of previous reports.

Published
2011

12. [A comparative study of cefepime for chronic respiratory tract infections]

Author

Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Hajime OHSHIRO, Takahiko MIYAKUNI, Jun INATOME, Soukichi ONODERA, Hitoshi NAKANO, Tetsuo SHIMIZU, Nobuhiro SASAKI, Toshiaki FUJIKANE, Yuka FUJITA, Takashi HIROSHIMA, Eiichi SAKAI, Akira SAITO, Yohmei HIRAGA, Mitsuhide OHMICHI, Tsukasa YOSHIDA, Hiromi KANAYAMA, Toshiharu ITO, Tamotsu TAKISHIMA, Yasuo TANNO, Ruriko SATO, Makoto TAKAHASHI, Masaharu SUGIYAMA, Masakichi MOTOMIYA, Akira WATANABE, Yoshihiro HONDA, Yutaka TOKUE, Kazunao NIIZUMA, Shigeo TAKIZAWA, Masataka KATSU, Katsutaka TORIKAI, Susumu SUETSUGU, Shunji YOSHIDA, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Takeru KOSHINO, Tetsuhei OGAWA, Yoshio KOBAYASHI, Hiroyuki KOBAYASHI, Takao OKUBO, Hirotada IKEDA, Shigeki ODAGIRI, Masanori MATSUMURA, Yasuhiko ASHIKARI, Yasutsugu AMANO, Akira SHOJI, Takashi SAKUMA, Nobuki AOKI, Kenzo TAKAGI, Kenichi YAMAKI, Kiyoshi SUZUKI, Yasunobu NODA, Hideo GONDA, Toshihiko TAKEUCHI, Johichi KATO, Fumiyuki KUZE, Takako MURAYAMA, Nobuaki IKEDA, Koichi NAKATANI, Kenji BANDO, Souichiro IKEDA, Tadaaki KURODA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Makoto KIMURA, Shunkichi HIRAKI, Yohichi WATANABE, Masashi ARAKI, Michiro YAMAKIDO, Kenji HASEGAWA, Takashi TSUYA, Kenichiro SADAMOTO, Masao KUWABARA, Masanobu OKADA, Kenichi ARITA, Masao DOI, Kazuhiro DAIDO, Jitsuro YANAGIDA, Kenichiro WATANABE, Yuichi ATA, Motohiro SUGIHARA, Masato YUKUTAKE, Kouichi AWAYA, Yoshihisa IHARA, Minoru YOSHIDA, Kentaro WATANABE, Takahito HIROSE, Kei SATO, Kohtaro OHIZUMI, Youichiro ICHIKAWA, Masako TANAKA, Kazuma FUJINO, Yoshiyuki MITSUTAKE, Mikio KUBUSHIRO, Toshihiro HIGASHI, Susumu HARADA, Yasuko HARADA, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Mitsuo KAKU, Keizo MATSUMOTO, Kazunori OHISHI, Hiroshi TANAKA, Kiyoshi SHIMA, Shinobu TAKENAKA, Masaru NASU, Yoichiro GOTO, Tohru YAMAZAKI, Hiroyuki NAGAI, Takayoshi TASHIRO, Nobuya OGAWA, and Nobuchika KUSANO

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.drug_class, Cefepime, Cephalosporin, Antibiotics, Ceftazidime, Microbial Sensitivity Tests, Internal medicine, medicine, Potency, Humans, Respiratory Tract Infections, Aged, Respiratory tract infections, Bacteria, business.industry, Incidence (epidemiology), Significant difference, General Medicine, Middle Aged, Cephalosporins, Chronic Disease, Female, business, medicine.drug
Abstract

The clinical efficacy, safety and usefulness of Cefepime (CFPM), a new cephem antibiotics, in chronic respiratory infections were evaluated in a comparative study against Ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at a dose of 1.0 g (nominal potency), twice daily for 14 days, and the following results were obtained: 1. A total of 170 cases were enrolled in this study. Efficacy rates ("good" or better responses) as evaluated by the subcommittee were 86.2% (56/65) in the CFPM group and 84.5% (60/71) in the CAZ group, with no significant difference between the two groups. 2. Efficacy rates ("good" or better responses) as evaluated by attending physicians were 83.3% (55/66) in the CFPM group and 84.5% (60/71) in the CAZ group with no significant difference between the two groups. 3. Bacteriologically, eradication rates were 83.3% (40/48) in the CFPM group and 88.2% (45/51) in the CAZ group, with no significant difference between the two groups. 4. Side effects occurred in none of the patients in the CAZ group and in 4 of the 66 patients in the CFPM group. There was a significant difference between the two groups (Fisher's test p = 0.0489). The incidence of abnormal laboratory findings were 17.6% (12/68) in the CFPM group and 21.1% (16/76) in the CAZ group. There was no significant difference between the two groups. 5. The utility rates evaluated by the subcommittee were 81.8% (54/66) in the CFPM group and 84.5% (60/71) in the CAZ group with no significant difference between the two groups. Only in the incidence of side effects, there was a significant difference between the two groups (Fisher's test p = 0.0489), but there was no significant difference in other items of efficacy, safety and usefulness between the two groups. These results indicate that CFPM is useful for the treatment of chronic respiratory tract infections.

Published
1992

13. A contact investigation of the transmission of Mycobacterium tuberculosis from a nurse working in a newborn nursery and maternity ward.

Author

Hitoshi Ohno, Yumiko Ikegami, Kenji Kishida, Yoshiaki Yamamoto, Nobuaki Ikeda, Takashi Taniguchi, Takeshi Ikeda, Atsuo Sato, Takuya Kurasawa, and Ken Miyanomae

Subjects
MYCOBACTERIUM tuberculosis, INFECTIOUS disease transmission, MYCOBACTERIAL diseases, INFECTION, TUBERCULOSIS
Abstract

Abstract  A nurse working in a newborn nursery and maternity ward developed 3+ smear-positive lung tuberculosis. The hospital infection control committee, in collaboration with the local public health and welfare center, conducted a contact investigation. The infection period was defined as April to August 2006. The investigation included 109 infant and mother pairs, 28 children aged under 10 years and their guardians, 62 coworkers, and 63 household visitors to the ward. Tuberculosis infection in infants and children aged under 5 years was primarily determined by tuberculin skin test (TST), while subjects aged 5 years or more were tested using QuantiFERON-TB Gold (QFT). The first investigation, in August 2006, was conducted in all subjects, and the second investigation, in October 2006, targeted selected subjects. No infants were TST-positive. Two children aged 1 year or under, vaccinated with bacillus Calmette-Guérin, were positive for TST, as determined by the criteria of the Japan Anti-Tuberculosis Association; however, other tests for tuberculosis were negative. Of the 13 QFT-positive adult subjects, 1 mother and 2 coworkers could have become infected with Mycobacterium tuberculosis through exposure to the index nurse. Fifty-four infants and 6 children underwent “window-period” prophylaxis, and 4 adults completed 6-month prophylactic treatment with isoniazid. To date, no secondary cases of tuberculosis disease have occurred. [ABSTRACT FROM AUTHOR]

Published
2008
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14. A Comparative Study Between Cefminox (MT-141) and Cefotaxime in Respiratory Tract Infections

Author

Fumio MIKI, Eiji INOUE, Masakazu TERAGAKI, Kaname AKIOKA, Minoru YOSHIYAMA, Toru HIRAGA, Tetsuto MURATA, Akira SAITO, Akira UJIIE, Morikuni ABE, Yoshinobu TAKASHIRO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Fumio NAGAHAMA, Takehito NAKABAYASHI, Tetsuji KOROKU, Yomei HIRAGA, Katsuo SUZUKI, Hiroshi KON, Yasumasa YOKOTA, Ryoji OHASHI, Jutaro SHIMOMURA, Yoichi GOCHO, Hisashi NISHIHARA, Kazuo TAKEBE, Mitsuo MASUDA, Seiichi MURAKAMI, Yoshihiro KUMASAKA, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaru OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Hisashi TAKIZUKA, Reiko SAITO, Keimei MASHIMO, Tetsuro UKAI, Hiroichi TANIMOTO, Ryuoh NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Hideo IKEMOTO, Kazuyoshi WATANABE, Atsushi SAITO, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Hiroyuki KOBAYASHI, Kota KONO, Kenji TAKAMURA, Hiroshi OSHITANI, Kokichi FUKUSHIMA, Akira ITO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Keinosuke NOSE, Kazufuto FUKAYA, Tadashi TAKIGAMI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Katsutaka TORIKAI, Mutsumi ASHIHARA, Tatsuo SUGIHARA, Nobuo MAEKAWA, Michiyasu NAKANISHI, Tsuneo MATSUBARA, Nobuaki IKEDA, Ataka SHIBATA, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Michifumi ADACHI, Osamu KURIMURA, Koji NOMA, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kenichi MATSUBA, Takahiro NAWATA, Masaro KAJI, Yoichiro ICHIKAWA, Nisaburo TANAKA, Toshiharu HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Kohei HARA, Atushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Munetaka KOMORI, Ken SHINZATO, Hirofumi OGATA, Naomi ITO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Takashi ITOGA, Masaru NASU, Yoichiro GOTO, Jun GOTO, and Takayoshi TASHIRO

Subjects
Clinical Trials as Topic, medicine.medical_specialty, Cefotaxime, Respiratory tract infections, Cefminox, business.industry, Lung abscess, Pneumonia, General Medicine, medicine.disease, Gastroenterology, Chronic disease, Internal medicine, Chronic Disease, medicine, Humans, Cephamycins, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985
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15. Response of Tension Leg Buoy to Vertical Seismic Excitations

Author

Toshimasa Kawanishi, Nobuaki Ikeda, and Wataru Kato

Subjects
Water depth, Engineering, Buoy, Tension (physics), business.industry, Equations of motion, Relative weight, Flexural rigidity, Structural engineering, North sea, business, Tension-leg platform
Abstract

The tension leg platform (TLP) has been studied since the 1970 s by Paulling et al., but has not been used so practically excepting Hutton TLP in the North Sea. The main reason is reliability on the strength of the tether. Therefore, most studies on TLP have related to the strength of the tether. The wave response of TLP and the tension of the tether were studied by Paulling, and Yoshida.Since TLP has been said to be an aseismatic structure, the earthquake force has not been considered on designing as an external force to the tether. It is true that the horizontal component of the earthquake can be ignored because the flexural stiffness of the tether is nearly zero. However, the tension fluctuation of the vertical component of the earthquake is an important factor on designing. Studies on the earthquake load of TLP is only little described in Penzien's paper, but it has not yet been clarified. The authors have made for years theoretical and experimental investigations on the earthquake response of TLP.In TLP motion analysis, the problem is usually simplified by idealizing the tether as simple springs. While this approximation appears to be generally adequate for shallow waters. The relative weight ratio (tether/platform) increases very rapidly as the water depth increases. Thus, it is necessary to treat the TLP under the earthquake as a continuous system rather than as a rigid body.In this study, motion equations on a tension leg buoy (TLB), taking the tether weight into consideration, were prepared to clarify the earthquake response.

Published
1987
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16. Comparative Study of BRL28500 (Clavulanic Acid-Ticarcilin) and Piperacillin in the Treatment of Respiratory Tract Infections

Author

Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Akira TAHARA, Akira SAITO, Masumi TAMIZAWA, Yohmei HIRAGA, Kohki KIKUCHI, Tomoko YAMAMOTO, Kazuo TAKABE, Teruo NAKAMURA, Tadashi MIYAZAWA, Toyokazu TAMURA, Katsumi ENDO, Masashi YONEDA, Yasuo IDO, Osamu UEHARA, Katsuhiro OKAMOTO, Morio SAGARA, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Akira WATANABE, Kazuo SATO, Izumi HAYASHI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Toshio FUKUI, Masaaki ARAKAWA, Koichi WADA, Takao MORIMOTO, Tomoko KABASAWA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Tadashi MIYAHARA, Atsushi SAITO, Jingoro SHIMADA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Masahiko YOSHIDA, Keimei MASHIMO, Yoshiji YAMANE, Toshiharu TOMI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDO, Takeshi OTA, Hiroichi TANIMOTO, Ryuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Takashi INAMATSU, Kyoko URAYAMA, Fuyuhiko AZUMA, Yuzo FUNATSU, Ippei FUJIMORI, Yoshio KOBAYASHI, Masanori ADACHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITO, Hiroshi MATSUMOTO, Junichi SUZUKI, Yasuhiro YOSHIIKE, Yuji WATANUKI, Shigeki ODAGIRI, Jun CHIBA, Kaneo SUZUKI, Koou MUROHASHI, Tsutomu FUKUDA, Mitsuyo KIUCHI, Yasuhiko ASHIKARI, Kaoru SHIMOKATA, Saiji YOSHII, Osamu TAKANOU, Shuzo SAKAI, Keisuke NISHIWAKI, Shigeki TAKEURA, Hirotsugu KISHIMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Motohide SASAMOTO, Tomoyasu SASAKI, Toshihiko TAKEUCHI, Masahito KATO, Joichi KATO, Goh ITO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Satoru ADACHI, Kaoru OYAMA, Kunikazu SUZUKI, Nobuo OTANI, Mitsuru HAYASE, Fumiyuki KUZE, Hiroyuki TSUJINO, Nobuo INABA, Nobuaki IKEDA, Tsuneo MATSUBARA, Shinichi USHIDA, Ryoichi AMITANI, Michiyasu NAKANISHI, Hiroshi OKUBO, Yoshihiro UEDA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Kojiro YASUNAGA, Seibun YONETSU, Yube IIDA, Yoshihiko SAKAKIBARA, Eiroh TSUBURA, Tomoo HAMADA, Koichi FUKUYAMA, Masahiro FUKUOKA, Masami ITO, Fumio HIRAO, Takashi KOMATSU, Nobuo MAEKAWA, Hideki NISHIYAMA, Yujiro SUZUKI, Sadao HORIKAWA, Masakazu TAMURA, Rinzo SOEJIMA, Yoshihito NIKI, Michifumi ADACHI, Yoshihisa NAKAGAWA, Masaru SUMI, Osamu KURIMURA, Hideyo SASAKI, Hirofumi FUKUHARA, Tadao MORIMOTO, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuaki SHIGEMATSU, Hisamichi AIZAWA, Masahide TAKII, Takafumi OHDO, Tomoaki SHINAGAWA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KOHNO, Hironobu KAGA, Koichi WATANABE, Kiyo FUJITA, Yasuko UEDA, Kota KOHNO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masaru NASU, Jun GOTO, Yoichiro GOTO, Hideaki SHIGENO, and Takayoshi TASHIRO

Subjects
Adult, Male, Penicillins, Microbiology, Clavulanic Acids, Clavulanic acid, medicine, Humans, Ticarcillin, Respiratory Tract Infections, Beta-Lactamase Inhibitors, Aged, Aged, 80 and over, Piperacillin, Clinical Trials as Topic, Respiratory tract infections, Chemistry, General Medicine, Middle Aged, Clavulanic acid + Ticarcillin, Drug Combinations, Female, beta-Lactamase Inhibitors, medicine.drug
Published
1987
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17. [Comparative clinical trial of HBK and amikacin (AMK) in the treatment of respiratory infections]

Author

Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoshiteru SHIGENO, Kazushige TAIRA, Toshiro ODA, Toshiaki HAYASHI, Hiroshi TOMITA, Yasuharu MASUYAMA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Morikuni ABE, Shosei MATSUHASHI, Kiyofumi ISHIKAWA, Akira UJIIE, Takehito NAKABAYASHI, Tetsuji KOROKU, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Katsuhiro OKAMOTO, Morio SAGARA, Toyokazu TAMURA, Katsumi ENDO, Tatsuro IRIE, Osamu UEHARA, Masao TAMURA, Takashi ITO, Kazuo OBARA, Shinya MIYAMOTO, Tomohiro KANAZAWA, Hiroshi TAKAHASHI, Hirokazu KUROKAWA, Shoji YASUI, Keiji TAKAHASHI, Shinobu SATO, Hideki IKEDA, Hidenori NAKAMURA, Seiji YASUMURA, Kohichi IGARASHI, Hikaru HOSHI, Sunao YAKUWA, Tamotsu TAKISHIMA, Shiroh IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Akira WATANABE, Kosaku NAGAI, Kazuo SATO, Izumi HAYASHI, Masataka KATSU, Mieko KAWAI, Koji OGIWARA, Takeshi KAWAI, Atsushi AJISAWA, Shigeaki SATO, Kazuhito ISHIKAWA, Tadashi MIYAHARA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroshi ISONUMA, Hiroyuki KOBAYASHI, Shin KAWAI, Masahiko YOSHIDA, Otohiko KUNII, Keimei MASHIMO, Yoshiji YAMANE, Tetsuro UKAI, Masaru KOYAMA, Fukuo IIJIMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yuko UNO, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Gohta MASUDA, Masayoshi NEGISHI, Chenden YOUNG, Fuyuhiko HIGASHI, Yuzo FUNATSU, Ippei FUJIMORI, Yoshio KOBAYASHI, Takao OKUBO, Akira ITO, Fumihiko SANO, Michio MATSUZAKI, Yuko ASADA, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MUROHASHI, Tsutomu FUKUDA, Yasuhiro YOSHIIKE, Masanori MATSUMURA, Mitsuyo KIUCHI, Fumio MATSUMOTO, Kazufuto FUKAYA, Tadashi TAKIGAMI, Masataka SHODA, Masaaki ARAKAWA, Kohichi WADA, Osamu SEKINE, Nobuki AOKI, Kaoru OYAMA, Shinobu NAKAMURA, Takeshi NAKAMURA, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akira ADACHI, Fumiyuki KUZE, Michiyasu NAKANISHI, Takuya KURASAWA, Yoshiro KUBO, Hideki NISHIYAMA, Nobuaki IKEDA, Norio INABA, Akira KAGIOKA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shin-ichi TANIZAWA, Kazuo SAKAMOTO, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Yoshihisa NAKAGAWA, Yukio NISHIMOTO, Michio YAMAKIDO, Akimitsu KAMITSUNA, Kenji HASEGAWA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Masakazu TAMURA, Eiro TSUBURA, Koichi FUKUYAMA, Tadaaki MORIMOTO, Yoshiro SAWAE, Hitoshi NAGANO, Takeo YOKOTA, Kinji YOKOTA, Atsushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yasuko HARADA, Yoshinari KITAHARA, Masaro KAJI, Yoichiro ICHIKAWA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Hitoshi YAMAZAKI, Takayoshi TASHIRO, Keizo MATSUMOTO, Kazunori OHISHI, Kinichi IZUMIKAWA, Tsunetoshi KOTEDA, Manabu NAKAJIMA, Kohei KOMATSU, Masaya NAKATA, Reiko SENJU, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Toshiyuki NAKAGAWA, Kazuko YOSHIDA, Kazumine KOBARI, Masao NAKATOMI, and Tsuneo TANAKA

Subjects
Adult, Male, medicine.medical_specialty, Double-Blind Method, Kanamycin, medicine, Humans, Respiratory system, Intensive care medicine, Amikacin, Respiratory Tract Infections, Aged, Aged, 80 and over, Clinical Trials as Topic, business.industry, Dibekacin, General Medicine, Bacterial Infections, Middle Aged, Anti-Bacterial Agents, Clinical trial, Aminoglycosides, Female, business, medicine.drug
Published
1987

18. [Comparative study of BRL28500 (clavulanic acid-ticarcillin) and ticarcillin in the treatment of respiratory tract infections]

Author

Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Akira TAHARA, Akira SAITO, Masumi TOMIZAWA, Yohmei HIRAGA, Kohki KIKUCHI, Tomoko YAMAMOTO, Kazuo TAKEBE, Teruo NAKAMURA, Tadashi MIYAZAWA, Toyokazu TAMURA, Katsumi ENDO, Masashi YONEDA, Yasuo IDO, Osamu UEHARA, Katsuhiro OKAMOTO, Morio SAGARA, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Akira WATANABE, Kazuo SATO, Izumi HAYASHI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Toshio FUKUI, Masaaki ARAKAWA, Koichi WADA, Takao MORIMOTO, Tomoko KABASAWA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Tadashi MIYAHARA, Atsushi SAITO, Jingoro SHIMADA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Masahiko YOSHIDA, Keimei MASHIMO, Yoshiji YAMANE, Toshiharu TOMI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDO, Takeshi OTA, Hiroichi TANIMOTO, Ryuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Takashi INAMATSU, Kyoko URAYAMA, Fuyuhiko AZUMA, Yuzo FUNATSU, Ippei FUJIMORI, Yoshio KOBAYASHI, Masanori ADACHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITO, Hiroshi MATSUMOTO, Junichi SUZUKI, Yasuhiro YOSHIIKE, Yuji WATANUKI, Shigeki ODAGIRI, Jun CHIBA, Kaneo SUZUKI, Koou MUROHASHI, Tsutomu FUKUDA, Mitsuyo KIUCHI, Yasuhiko ASHIKARI, Kaoru SHIMOKATA, Saiji YOSHII, Osamu TAKANOU, Shuzo SAKAI, Keisuke NISHIWAKI, Shigeki TAKEURA, Hirotsugu KISHIMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Motohide SASAMOTO, Tomoyasu SASAKI, Toshihiko TAKEUCHI, Masahito KATO, Joichi KATO, Goh ITO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Satoru ADACHI, Kaoru OYAMA, Kunikazu SUZUKI, Nobuo OTANI, Mitsuru HAYASE, Fumiyuki KUZE, Hiroyuki TSUJINO, Nobuo INABA, Nobuaki IKEDA, Tsuneo MATSUBARA, Shinichi USHIDA, Ryoichi AMITANI, Michiyasu NAKANISHI, Hiroshi OKUBO, Yoshihiro UEDA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Kojiro YASUNAGA, Seibun YONETSU, Yube IIDA, Yoshihiko SAKAKIBARA, Eiroh TSUBURA, Tomoo HAMADA, Koichi FUKUYAMA, Masahiro FUKUOKA, Masami ITO, Fumio HIRAO, Takashi KOMATSU, Nobuo MAEKAWA, Hideki NISHIYAMA, Yujiro SUZUKI, Sadao HORIKAWA, Masakazu TAMURA, Rinzo SOEJIMA, Yoshihito NIKI, Michifumi ADACHI, Yoshihisa NAKAGAWA, Masaru SUMI, Osamu KURIMURA, Hideyo SASAKI, Hirofumi FUKUHARA, Tadao MORIMOTO, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuaki SHIGEMATSU, Hisamichi AIZAWA, Masahide TAKII, Takafumi OHDO, Tomoaki SHINAGAWA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KOHNO, Hironobu KOGA, Koichi WATANABE, Kiyo FUJITA, Yasuko UEDA, Kota KOHNO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masaru NASU, Jun GOTO, Yoichiro GOTO, Hideaki SHIGENO, and Takayoshi TASHIRO

Subjects
Adult, Aged, 80 and over, Clinical Trials as Topic, Chemistry, General Medicine, Penicillins, Middle Aged, Clavulanic acid + Ticarcillin, Microbiology, Clavulanic Acids, Drug Combinations, Ticarcillin, medicine, Humans, beta-Lactamase Inhibitors, Respiratory Tract Infections, medicine.drug, Aged
Published
1987

19. [A double-blind comparative study of aspoxicillin and piperacillin in the treatment of respiratory tract infections]

Author

Akira SAITO, Kiyofumi ISHIKAWA, Ichiro NAKAYAMA, Masumi TOMIZAWA, Morikuni ABE, Hidetoshi SHIBAKI, Takehisa CHIMOTO, Masahiro TANAKA, Choei ITO, Keisuke TAKEUCHI, Aiji KOJIMA, Kazuo SHIMOYAMA, Yoshinobu TAKASHIRO, Shinji OHNISHI, Masahide SHINOHARA, Akira UJIIE, Osamu YAJIMA, Fumio NAGAHAMA, Hisaji NISHIHARA, Yuichi SASAKI, Takehito NAKABAYASHI, Tetsuji KOROKU, Rensuke KURODA, Jutaro SHIMOMURA, Shin-ichi OSHIMA, Sokichi ONODERA, Nobuhiro SASAKI, Akira SUZUKI, Tohru NATSUIZAKA, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Tsuyoshi KIKUIRI, Tadashi MURAKAMI, Kazufumi TSUCHIHASHI, Kazuo TAKEBE, Katsuhiro OKAMOTO, Shuichiro TOSHIDA, Tadanao OHMI, Shuichi TAKAHASHI, Katsutoshi KARIYA, Tomio ONUMA, Shigeru OCHIAI, Yoshihiro KUMASAKA, Shigetoshi YANAGIYA, Osamu UEHARA, Yasukimi WATABIKI, Naoyoshi MASAKI, Toyoichi TAMURA, Naoki TAMAZAWA, Hajime INOOKA, Masao TAMURA, Takashi ITOH, Ken-ichi TAKEUCHI, Ryoji OGATA, Jun KOMURO, Hiroaki ITOH, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaro OHIZUMI, Akira WATANABE, Makoto KASHIWAGI, Hideo TOGASHI, Hidetaka SATO, Masato HAYASHI, Tsugushi ITOH, Izumi HAYASHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Masataka KATSU, Masanori ADACHI, Keimei MASHIMO, Tetsuro UKAI, Chizuru ITOH, Atsushi SAITO, Tadashi MIYAHARA, Hiroichi TANIMOTO, Akio TACHIBANA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keiichi NAKAGAWA, Masaru KOYAMA, Kohjin KIN, Masami UEDA, Fukuo IIJIMA, Ryuji AKIYOSHI, Yuzo FUNATSU, Fuyuhiko HIGASHI, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Ippei FUJIMORI, Yoshio KOBAYASHI, Yasushi NAKAMURA, Kazufuto FUKAYA, Kenzo TAKAGI, Ikuo YAMAKAWA, Michihiro HARA, Tatsuo SATAKE, Toshihiko TAKEUCHI, Masahito KATO, Saburo KITAURA, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Youichi ABE, Katsutaka TORIGAI, Kaoru OHYAMA, Kuninori SUZUKI, Nobuo OHYA, Mitsuru HAYASE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Kohei AOKI, Tsuneo MATSUBARA, Nobuaki IKEDA, Takekuni IWATA, Nobuo INABA, Hiroyuki TSUJINO, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Hiroshi OKUBO, Yoshihiro UEDA, Fumio MIKI, Kenji TAKAMATSU, Osamu MIYAMOTO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Rinzo SOEJIMA, Yoshito NIKI, Masatoshi WATANABE, Michio YAMAKIDO, Kanoko HAYASHI, Yoshiro SAWAE, Tomohiro KUSABA, Seizaburo KASHIWAGI, Akira UEDA, Kaoru OKADA, Michio ONO, Masahide TAKII, Takatoshi OTONARI, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masao NAGASAWA, Keizo MATSUMOTO, Harumi SHISHIDO, Atsushi TAKAHASHI, Masakazu TAKASUGI, Shigeru TAMAKI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Katsumasa TOKUNAGA, Yasutsugu FUKUDA, and Haruhiko TOKUOMI

Subjects
Piperacillin, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Lung abscess, General Medicine, Pneumonia, medicine.disease, Double blind, Aspoxicillin, Chronic disease, Double-Blind Method, Internal medicine, Chronic Disease, medicine, Humans, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985

20. [Comparative study of MK-0787/MK-0791 and piperacillin in respiratory tract infections]

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Hiroshi KAWANE, Yoshihito NIKI, Masayoshi KAWANISHI, Chikara NAKAHAMA, Jiro HINO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kazuo TAKEBE, Yoshihiro KUMASAKA, Teruo NAKAMURA, Tsukasa YOSHIDA, Masayuki YOSHIZAWA, Kazuo MIZUKOSHI, Shiroh IDA, Tamotus TAKISHIMA, Seiichi AONUMA, Akira WATANABE, Kotaro OIZUMI, Kiyoshi KONNO, Tsugushi ITOH, Izumi HAYASHI, Masaaki ARAKAWA, Koichi WADA, Ryohji YOSHIDA, Ariyoshi KONDOH, Akio HOSHINO, Koichi HIRONO, Yukio NOZAWA, Haruo TERADA, Ryozoh ASANO, Masanori NARITA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Shizuo HASEGAWA, Yasuyuki YOSHIZAWA, Yoshiaki KAMEYAMA, Yoshiyuki UCHIDA, Masataka KATSU, Toshio FUKUI, Hajime YAMAGATA, Mieko KAWAI, Reiko SAITO, Minoru SATO, Takashi YOKOSE, Takeshi KAWAI, Akio ONAKA, Atsushi AJISAWA, Takeshi KAMO, Fuyuhiko HIGASHI, Masahiko NAKAMURA, Kazumi ARIKAWA, Keiichi YAMAGAMI, Makoto TAKANO, Sozo NUMASA, Yuzo FUNATSU, Mitsuo KITAHARA, Yukinori TAKAHASHI, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Yoshitaka NAKAMORI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDOH, Toshinobu SATOH, Makoto DOI, Keimei MASHIMO, Tetsuro UKAI, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Motokazu TANAKA, Hajime MORINARI, Syuichi OKUBO, Kazuo FUJIEDA, Toshio ITOH, Kihachiro SHIMIZU, Teppei KUMADA, Satoshi OOI, Kyoichi TOTSUKA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Masahiko YOSHIDA, Ippei FUJIMORI, Yoshio KOBAYASHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITOH, Shigeki ODAGIRI, Hideyuki HASEGAWA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Hideo TAKAHASHI, Tomiji MIURA, Fumio MATSUMOTO, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Kunio NANJO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Naohiro YAMASHITA, Kiyoshi HOSHINO, Eiji SUGIYAMA, Yutaka MIZUSHIMA, Saburo YANO, Kaoru OYAMA, Hideki NISHIYAMA, Hitoshi NAKAI, Kazukiyo OIDA, Nobuaki IKEDA, Hiroyuki TSUJINO, Mitsuo HASE, Eiichi MATSUYAMA, Fumiyuki KUZE, Yuruko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiro UEDA, Hiroshi OKUBO, Fumio MIKI, Akihito MURATA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Michio YAMAKIDO, Masao KUWABARA, Toshiya NOMURA, Toyofumi MITSUYAMA, Horoyuki ARITA, Akimitsu KAMITSUNA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Yoshiyuki NIHO, Nobuaki SHIGEMATSU, Osamu KOHASHI, Kiyoshi NINOMIYA, Hitoshi NAGANO, Takahito HIROSE, Atsusi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Shigeru KOHNO, Yoshiteru SHIGENO, Toshiro ODA, Hirosuke OHTA, Takashige MIYAZAKI, Toshiyuki OYE, Keizo MATSUMOTO, Naoto RIKITOMI, Tsuyoshi NAGATAKE, Harumi SISIDO, Yoshio UZUKA, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yoshinobu KURODA, Shukuro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yuei IRABU, Minoru HIGA, and Hiroaki NAKAMURA

Subjects
Adult, Cyclopropanes, Male, Piperacillin, Respiratory tract infections, business.industry, Cilastatin, Imipenem Drug Combination, General Medicine, Middle Aged, Drug Administration Schedule, Drug Combinations, Imipenem, Cilastatin, Immunology, Medicine, Humans, Female, Thienamycins, business, Infusions, Intravenous, Respiratory Tract Infections, medicine.drug, Aged
Published
1986

21. [Untitled]

Author

Nobuaki Ikeda, Satoshi Ueda, and Mitsuru Majima

Subjects
Pediatrics, medicine.medical_specialty, Guillain-Barre syndrome, business.industry, medicine, business, medicine.disease
Published
1981
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