1. Report of a Case of Schnitzler’s Syndrome Treated Successfully with Interferon Alpha 2b
- Author
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Ralph Paus, Wolfram Sterry, Hans Sperl, Katharina Krüger, Beate Tebbe, Heike Audring, Suzanne Buder, and Noël Emile Célestin Schartz
- Subjects
Male ,medicine.medical_specialty ,Urticaria ,medicine.medical_treatment ,Pain ,Alpha interferon ,Dermatology ,Interferon alpha-2 ,Gastroenterology ,Bone and Bones ,immune system diseases ,Internal medicine ,Immunopathology ,Gammopathy ,medicine ,Humans ,Schnitzler Syndrome ,skin and connective tissue diseases ,Chronic urticaria ,Interferon alfa ,Skin ,Chemotherapy ,S syndrome ,business.industry ,Interferon-alpha ,Middle Aged ,medicine.disease ,Recombinant Proteins ,Schnitzler syndrome ,Immunology ,business ,medicine.drug - Abstract
Schnitzler’s syndrome (SS) is characterized by the association of generalized chronic urticaria, osteocondensation and monoclonal IgM gammopathy. Nonsteroidal anti-inflammatory drugs and systemic steroids are the most promising treatments. In our patient, they were ineffective. By contrast, during the follow-up period of 18 months, interferon α2b therapy (IFN-α) relieved the patient from its urticarial lesions and bone pain. IFN-α was tried to be stopped twice: each time, relapse of urticaria was noticed and, each time, the cutaneous lesions disappeared after IFN-α had been reintroduced. Furthermore, our observation supports the idea of the interleukin (IL)-1-mediated pathogenesis of SS as IFN-α induces high levels of IL-1 receptor antagonists. IFN-α could be an alternative treatment in disabling SS resisting other drugs.
- Published
- 2002
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