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98 results on '"Noël, Harold"'

1. SARS-CoV-2 infection prevalence and associated factors among primary healthcare workers in France after the third COVID-19 wave

Author

Pouquet, Marie, Decarreaux, Dorine, Di Domenico, Laura, Sabbatini, Chiara E., Prévot-Monsacre, Pol, Fourié, Toscane, Villarroel, Paola Mariela Saba, Priet, Stephane, Blanché, Hélène, Sebaoun, Jean-Marc, Deleuze, Jean-François, Turbelin, Clément, Rossignol, Louise, Werner, Andréas, Kochert, Fabienne, Grosgogeat, Brigitte, Rabiega, Pascaline, Laupie, Julien, Abraham, Nathalie, Noël, Harold, van der Werf, Sylvie, Colizza, Vittoria, Carrat, Fabrice, Charrel, Remi, de Lamballerie, Xavier, Blanchon, Thierry, and Falchi, Alessandra

Published
2024
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2. History of smallpox vaccination and marked clinical expression of mpox among cases notified in France from May to July 2022

Author

Moukaila, Abdoul Djamal, Yamada, Ami, Ahamadi, Amina, Bernadou, Anne, Guinard, Anne, Laporte, Anne, Oulebsir, Asma Saidouni, Diavolo, Audrey, Zhu-Soubise, Aurélien, Grellier, Axel, Demma, Brigitte, Grenier, Carine, Dagorne, Carole, Aventini, Catherine, Bec, Catherine, Erieau, Céline, Meffre, Christine, Pere, Christine, Leyendecker, Clara, Ott, Damien, François, Diane, Brottet, Elise, Balleydier, Elsa, Fougere, Erica, Didier, Florence, Lot, Florence, Dorleans, Frédérique, Yubero, Gabriel, El Kouri, Jacques, Chappert, Jean-Loup, Guyonnet, Jean-Paul, Berra, Julien, Ali-Oicheih, Laetitia, Petit-Made, Laure, Reques, Laura, Marais, Laurence, Agbahoungba, Lazare, Beikheira, Leila, Luan, Louise, Sautron, Lucie, Barba-Vasseur, Marie, Louault, Marion, Bonnet, Nathalie, Mathevet, Nathalie, Sow, Ndeye Fatou, Glass, Olivier, Baguet, Patrick, Calen, Patrick, Rolland, Patrick, Reboud, Philippe, Le Barreau, Robin, Ollivier, Ronan, De Souza, Sander, Fournier, Sabrina, Grellet, Sophie, Alizada, Ulviyya, Henry, Valerie, Pontiès, Valérie, Dachary, Victorien, Silue, Yassoungo, Mallet, Yoann, Souares, Yvan, Krug, Catarina, Chazelle, Emilie, Tarantola, Arnaud, Noël, Harold, Spaccaferri, Guillaume, Parent du Châtelet, Isabelle, Zanetti, Laura, Lahbib, Hana, Fayad, Myriam, De Valk, Henriette, Che, Didier, Coignard, Bruno, Mailles, Alexandra, and Barret, Anne-Sophie

Published
2024
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4. Genomic analysis of Vibrio cholerae O1 isolates from cholera cases, Europe, 2022.

Author

Rouard, Caroline, Greig, David R., Tauhid, Thamida, Dupke, Susann, Njamkepo, Elisabeth, Amato, Ettore, van der Putten, Boas, Naseer, Umaer, Blaschitz, Marion, Mandilara, Georgia D., Stuart, James Cohen, Indra, Alexander, Noël, Harold, Sideroglou, Theologia, Heger, Florian, van den Beld, Maaike, Wester, Astrid Louise, Quilici, Marie-Laure, Scholz, Holger C., and Fröding, Inga

Published
2024
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6. Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study

Author

Bougeard, Stéphanie, primary, Huneau-Salaun, Adeline, additional, Attia, Mikael, additional, Richard, Jean-Baptiste, additional, Demeret, Caroline, additional, Platon, Johnny, additional, Allain, Virginie, additional, Le Vu, Stéphane, additional, Goyard, Sophie, additional, Gillon, Véronique, additional, Bernard-Stoecklin, Sibylle, additional, Crescenzo-Chaigne, Bernadette, additional, Jones, Gabrielle, additional, Rose, Nicolas, additional, van der Werf, Sylvie, additional, Lantz, Olivier, additional, Rose, Thierry, additional, and Noël, Harold, additional

Published
2023
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8. Application of Machine Learning Prediction of Individual SARS-CoV-2 Vaccination and Infection Status to the French Serosurveillance Survey From March 2020 to 2022: Cross-Sectional Study (Preprint)

Author

Bougeard, Stéphanie, primary, Huneau-Salaun, Adeline, additional, Attia, Mikael, additional, Richard, Jean-Baptiste, additional, Demeret, Caroline, additional, Platon, Johnny, additional, Allain, Virginie, additional, Le Vu, Stéphane, additional, Goyard, Sophie, additional, Gillon, Véronique, additional, Bernard-Stoecklin, Sibylle, additional, Crescenzo-Chaigne, Bernadette, additional, Jones, Gabrielle, additional, Rose, Nicolas, additional, van der Werf, Sylvie, additional, Lantz, Olivier, additional, Rose, Thierry, additional, and Noël, Harold, additional

Published
2023
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9. Attitudes towards booster, testing and isolation, and their impact on COVID-19 response in winter 2022/2023 in France, Belgium, and Italy: a cross-sectional survey and modelling study

Author

de Meijere, Giulia, primary, Valdano, Eugenio, additional, Castellano, Claudio, additional, Debin, Marion, additional, Kengne-Kuetche, Charly, additional, Turbelin, Clément, additional, Noël, Harold, additional, Weitz, Joshua S., additional, Paolotti, Daniela, additional, Hermans, Lisa, additional, Hens, Niel, additional, and Colizza, Vittoria, additional

Published
2023
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10. Attitudes towards booster, testing and isolation, and their impact on COVID-19 response in winter 2022/2023 in France, Belgium, and Italy

Author

de Meijere, Giulia, primary, Valdano, Eugenio, additional, Castellano, Claudio, additional, Debin, Marion, additional, Kengne-Kuetche, Charly, additional, Turbelin, Clément, additional, Noël, Harold, additional, Weitz, Joshua, additional, Paolotti, Daniela, additional, Hermans, Lisa, additional, Hens, Niel, additional, and Colizza, Vittoria, additional

Published
2023
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11. Outbreak of urogenital schistosomiasis in Corsica (France): an epidemiological case study

Author

Boissier, Jérôme, Grech-Angelini, Sébastien, Webster, Bonnie L, Allienne, Jean-François, Huyse, Tine, Mas-Coma, Santiago, Toulza, Eve, Barré-Cardi, Hélène, Rollinson, David, Kincaid-Smith, Julien, Oleaga, Ana, Galinier, Richard, Foata, Joséphine, Rognon, Anne, Berry, Antoine, Mouahid, Gabriel, Henneron, Rémy, Moné, Hélène, Noel, Harold, and Mitta, Guillaume

Published
2016
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13. Long lasting anti-IgG chikungunya seropositivity in the Mayotte population will not be enough to prevent future outbreaks: A seroprevalence study, 2019.

Author

Ortu, Giuseppina, Grard, Gilda, Parenton, Fanny, Ruello, Marc, Paty, Marie-Claire, Durand, Guillaume André, Hassani, Youssouf, De Valk, Henriette, and Noël, Harold

Subjects
CHIKUNGUNYA, ARBOVIRUS diseases, COVID-19, SEROCONVERSION, SEROPREVALENCE, SERODIAGNOSIS, POISSON regression, MOSQUITO control
Abstract

Chikungunya is an arboviral disease causing arthralgia which may develop into a debilitating chronic arthritis. In Mayotte, a French overseas department in the Indian Ocean, a chikungunya outbreak was reported in 2006, affecting a third of the population. We aimed at assessing the chikungunya seroprevalence in this population, after over a decade from that epidemic. A multi-stage cross sectional household-based study exploring socio-demographic factors, and knowledge and attitude towards mosquito-borne disease prevention was carried out in 2019. Blood samples from participants aged 15–69 years were taken for chikungunya IgG serological testing. We analyzed associations between chikungunya serological status and selected factors using Poisson regression models, and estimated weighted and adjusted prevalence ratios (w/a PR). The weighted seroprevalence of chikungunya was 34.75% (n = 2853). Seropositivity for IgG anti-chikungunya virus was found associated with living in Mamoudzou (w/a PR = 1.49, 95%CI: 1.21–1.83) and North (w/a PR = 1.41, 95%CI: 1.08–1.84) sectors, being born in the Comoros islands (w/a PR = 1.30, 95%CI: 1.03–1.61), being a student or unpaid trainee (w/a PR = 1.35, 95%CI: 1.01–1.81), living in precarious housing (w/a PR = 1.30, 95%CI: 1.02–1.67), accessing water streams for bathing (w/a PR = 1.72, 95%CI: 1.1–2.7) and knowing that malaria is a mosquito-borne disease (w/a PR = 1.42, 95%CI: 1.21–1.83). Seropositivity was found inversely associated with high education level (w/a PR = 0.50, 95%CI: 0.29–0.86) and living in households with access to running water and toilets (w/a PR = 0.64, 95%CI: 0.51–0.80) (n = 1438). Our results indicate a long-lasting immunity from chikungunya exposure. However, the current population seroprevalence is not enough to protect from future outbreaks. Individuals naïve to chikungunya and living in precarious socio-economic conditions are likely to be at high risk of infection in future outbreaks. To prevent and prepare for future chikungunya epidemics, it is essential to address socio-economic inequalities as a priority, and to strengthen chikungunya surveillance in Mayotte. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Seroprevalence of SARS-CoV-2 IgG Antibodies and Factors Associated with SARS-CoV-2 IgG Neutralizing Activity among Primary Health Care Workers 6 Months after Vaccination Rollout in France

Author

Decarreaux, Dorine, primary, Pouquet, Marie, additional, Souty, Cecile, additional, Vilcu, Ana-Maria, additional, Prévot-Monsacre, Pol, additional, Fourié, Toscane, additional, Villarroel, Paola Mariela Saba, additional, Priet, Stephane, additional, Blanché, Hélène, additional, Sebaoun, Jean-Marc, additional, Deleuze, Jean-François, additional, Turbelin, Clément, additional, Werner, Andréas, additional, Kochert, Fabienne, additional, Grosgogeat, Brigitte, additional, Rabiega, Pascaline, additional, Laupie, Julien, additional, Abraham, Nathalie, additional, Guerrisi, Caroline, additional, Noël, Harold, additional, Van der Werf, Sylvie, additional, Carrat, Fabrice, additional, Hanslik, Thomas, additional, Charrel, Remi, additional, De Lamballerie, Xavier, additional, Blanchon, Thierry, additional, and Falchi, Alessandra, additional

Published
2022
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17. Nosocomial Malaria Transmissions Resolved by Genomic Analyses—A Retrospective Case Report Study in France: 2007–2021.

Author

Coppée, Romain, Sarrasin, Véronique, Zaffaroulah, Rizwana, Bouzayene, Azza, Thellier, Marc, Noël, Harold, Clain, Jérôme, Houzé, Sandrine, and Group, the Investigation Study

Subjects
DNA, CROSS infection, RETROSPECTIVE studies, GENETIC polymorphisms, MALARIA, GENOMICS, RESEARCH funding, CASE studies, INFECTIOUS disease transmission, PARASITIC diseases, ANTIMALARIALS, COVID-19 pandemic
Abstract

Background Exposure of blood to malaria parasites can lead to infection even in the absence of the mosquito vector. During a stay in a healthcare facility, accidental inoculation of the skin with blood from a malaria patient might occur, referred to as nosocomial malaria. Methods Between 2007 and 2021, we identified 6 autochthonous malaria cases that occurred in different French hospitals, originating from nosocomial transmission and imported malaria cases being the infection source. Four cases were observed during the coronavirus disease 2019 pandemic. The genetic relatedness between source and nosocomial infections was evaluated by genome-wide short tandem repeats (STRs) and single-nucleotide polymorphisms (SNPs). Results None of the patients with autochthonous malaria had travel history to an endemic area nor had been transfused. For each case, both the source and recipient patients stayed a few hours in the same ward. After diagnosis, autochthonous cases were treated with antimalarials and all recovered except 1. Genetically, each pair of matched source/nosocomial parasite infections showed <1% of different STRs and <6.9% (<1.5% for monoclonal infections) of different SNPs. Similar levels of genetic differences were obtained for parasite DNA samples that were independently sequenced twice as references of identical infections. Parasite phylogenomics were consistent with travel information reported by the source patients. Conclusions Our study demonstrates that genomics analyses may resolve nosocomial malaria transmissions, despite the uncertainty regarding the modes of contamination. Nosocomial transmission of potentially life-threatening parasites should be taken into consideration in settings or occasions where compliance with universal precautions is not rigorous. [ABSTRACT FROM AUTHOR]

Published
2023
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18. Outbreak of Shiga Toxin—Producing Escherichia coli O104:H4 Associated With Organic Fenugreek Sprouts, France, June 2011

Author

Weill, Francxois-Xavier, King, Lisa A., Nogareda, Francisco, Weill, François-Xavier, Mariani-Kurkdjian, Patricia, Loukiadis, Estelle, Gault, Gaëlle, Jourdan-DaSilva, Nathalie, Bingen, Edouard, Macé, Muriel, Thevenot, Delphine, Ong, Nathalie, Castor, Christine, Noël, Harold, Van Cauteren, Dieter, Charron, Martine, Vaillant, Véronique, Aldabe, Benedicte, Goulet, Véronique, Delmas, Gilles, Couturier, Elisabeth, Le Strat, Yann, Combe, Christian, Delmas, Yahsou, Terrier, François, Vendrely, Benoit, Rolland, Patrick, and de Valk, Henriette

Published
2012
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21. Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol

Author

Pouquet, Marie, primary, Decarreaux, Dorine, additional, Prévot-Monsacré, Pol, additional, Hervé, Corentin, additional, Werner, Andréas, additional, Grosgogeat, Brigitte, additional, Blanché, Hélène, additional, Rabiega, Pascaline, additional, Laupie, Julien, additional, Kochert, Fabienne, additional, Abraham, Nathalie, additional, Sebaoun, Jean-Marc, additional, de Lamballerie, Xavier, additional, Charrel, Remi, additional, Souty, Cecile, additional, Camara, Ibrahima, additional, Pergeline, Jeanne, additional, Noël, Harold, additional, Guerrisi, Caroline, additional, Werf, Sylvie van der, additional, Carrat, Fabrice, additional, Hanslik, Thomas, additional, Blanchon, Thierry, additional, and Falchi, Alessandra, additional

Published
2021
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23. Mortality from malaria in France, 2005 to 2014

Author

Kendjo, Eric, Thellier, Marc, Noël, Harold, Jauréguiberry, Stéphane, Septfons, Alexandra, Mouri, Oussama, Gay, Frédérick, Tantaoui, Ilhame, Caumes, Eric, Houzé, Sandrine, Piarroux, Renaud, Musset, Lise, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence du Paludisme [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Santé publique France Guyane, Santé publique France - French National Public Health Agency [Saint-Maurice, France], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Parasitologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The French imported malaria Study group: C. Strady (CHU Reims), Caroline Lohmann (CH du Moenchsberg, Mulhouse), Celine Arriuberge (CH Trousseau, Paris), Emmanuel Grimprel (CH Trousseau, Paris), Jean-Marie Delarbre (CH du Moenchsberg, Mulhouse), Michel Thibault (CH René Dubos, Pontoise), Mohamadou Niang (CHR Orléans), A. Barrans (CH Sète), A. Martin (CH Périgueux), A. Spiegel (DESP Nord), A. Valentin (CHU Toulouse), A.S. Le Guern (Institut Pasteur, Paris), Adela Angoulvant (CHU Kremlin-Bicêtre, Paris), Adeline Dubois (CH Alès), Adrien Genin (CH Pays d'Aix), Agathe Lebuisson (CHU Cochin), Agnes Riche (CH Angoulême), Agnès Durand (Institut Pasteur, Paris), Agnès Fromont (CH Auxerre), Ahmed Aboubacar (CHU de Strasbourg), Ahmed Fateh Ousser (CH Louis Mourier), Aida Taieb (INTS, Paris), Alain Domergue (CH Alès - Cévennes), Alain Gravet (CH du Moenchsberg, Mulhouse), Alain Lecoustumier (CH de Cahors), Albert Faye (CHU Robert Debré, Paris), Alexander Pfaff (CHU de Strasbourg), Alexandra Faussart (CHU Bichat-Claude Bernard, Paris), Alexandre Chlilek (CHU Nîmes), Alice Borel (CHU Amiens), Alice Pérignon (CHU Pitié-Salpêtrière, Paris), Ana Mendes-Mreira (CH La Rochelle), André Gardrat (CH d’Evreux), Ange Kissila (CH Provins), Angèle LI (CH Creil (Laënnec)), Anne Cady (CH Bretagne Atlantique), Anne Debourgogne (CHU de Nancy), Anne Delaval (CHI Robert Ballanger, Aulnay-sous-Bois), Anne Goepp (CHI Villeneuve St Georges), Anne Marfaing-Koka (Hôpital Antoine-Béclère), Anne Pauline Bellanger (CHU Besançon, Jean Minjoz), Anne Vincenot-Blouin (CH Meaux), Anne-Marie Teychene-Coutet (CH Bondy-Jean Verdier), Anne-Sophie Deleplancque (CH Lille), Annick Verhaeghe (CH de Dunkerque), Annie Motard-Picheloup (CHI Fréjus St Raphaël), Antoine Berry (CHU Toulouse), Antoine Huguenin (CHU Reims), Arnaud Bouvet (CH Bretagne Atlantique), Audrey Merens (HIA Begin), Aurelie Roide (CHU Lariboisière, Paris), Aurore Sanson (CH Jacques Cœur, Bourges), Aurélie Fricot (CHU Necker), Aurélie Guigon (CHR Orléans), Benfatallah Dhouha (CHU Necker, Paris), Benjamin Wyplosz (CHU Kremlin-Bicêtre, Paris), Benoît Henri (INTS, Paris), Bernadette Buret (CH Niort), Bernadette Cuisenier (CHU Dijon), Bernadette Worms (CHU Dijon), Bernard Faugère (CH Timone, Marseille), Biligui Sylvestre (CHU Pitié-Salpêtrière, Paris), Boualem Sendid (CH Lille), Bruno Megarbane (CHU Lariboisière, Paris), Bruno Pradines (Département Microbiologie et Maladies Infectieuses, Institut de Recherche Biomédicale des Armées, 13005 Marseille, France, Aix Marseille University, IRD, SSA, AP-HM, VITROME, 13005 Marseille, France, IHU Méditerranée Infection, 13005 Marseille, France, Centre National de Référence du Paludisme, Institut de Recherche Biomédicale des Armées, 13005 Marseille, France), Béatrice Quinet (CH Trousseau, Paris), C. Braidy (CH du Sud Seine et Marne), C. Farrugia (CH de Dourdan), C. Finot (CH de Dreux), Camille Roussel (INTS, Paris), Camille Runel-Belliard (CHU de Bordeaux), Caren Brump (CHU Lariboisière, Paris), Carine Dokoula (CH Jacques Cœur, Bourges), Carmina Camal (CH Louis Mourier), Carole Mackosso (CHU Bichat-Claude Bernard, Paris), Carole Poupon (CH de Gonesse), Caroline Garandeau (CH Angoulême), Catherine Benoit (CH du Sud Seine et Marne), Catherine Branger (CH Louis Mourier), Catherine Brehant (CH La Rochelle), Catherine Desideri-Vaillant (HIA Clermont Tonnerre, Brest), Catherine Kauffmann Lacroix (CH Poitiers), Catherine Lafaurie (CH d’Epernay), Cecile Hombrouck-Alet (CH Blois), Cecile Ramade (Lyon-Croix-Rousse), Celine Damiani (CHU Amiens), Celine Gourmel (CHU Lariboisière, Paris), Chantal Duhamel (CHU Côte de Nacre), Chantal Garabedian (CH Pays d'Aix), Chralotte Chambrion (INTS, Paris), Christelle Morelle (CHU Montpellier), Christelle Pomares Estran (CH Universitaire de Nice), Christelle Prince (CH de Cayenne Andrée Rosemon), Christian Durand (CH Provins), Christian Fulleda (CHU Lariboisière, Paris), Christian Raccurt (CHU Amiens), Christine Chaigneau (GHPSO, Creil), Christine Chemla (CHRU de Reims), Christine Van batten (CH Laënnec, Creil), Christophe Martinaud (HIA Percy, Clamart), Christophe Rapp (HIA Begin), Claire Augé (CHU Bichat-Claude Bernard, Paris), Claire Malbrunot (CH Corbeil Essonne), Claudine Febvre (CH de Montbéliard), Claudine Sarfati (Hôpital Saint-Louis, Paris), Coralie l'Ollivier (CH de la Timone, Marseille), Corinne Huet (Hôpital Louis-Pasteur, Cherbourg-Octeville), Cournac Jean-Marie (HIA Percy, Clamart), Cynthia Pianetti (CH Gabriel Martin, La Réunion), Cécile Angebault (CHU Necker, Paris), Cécile Ficko (HIA Begin), Cécile Garnaud (CHU de Grenoble), Cécile Leprince (CHI Robert Ballanger, Aulnay-sous-Bois), Céliat Merat (CHU Nantes), Céline Dard (CHU de Grenoble), Céline Nourrisson (CHRU Clermont-Ferrand), Céline Tournus (Hôpital Delafontaine, Saint-Denis), Daniel Azjenberg (CHU Dupuytren, Limoges), Daniel Camus (CH Lille), Daniel Lusina (CHI Robert Ballanger, Aulnay-sous-Bois), Daniel Parzy (IMTSSA, Marseille), Denis Pons (CHRU Clermont-Ferrand), Denis Filisetti (CHU Strasbourg), Denis Malvy (CHU de Bordeaux), Didier Basset (CHU Montpellier), Didier Jan (CH Laval), Didier Poisson (CHR Orléans), Didier Raffenot (CH Chambéry), Dieudonné Bemba (CH Bondy-Jean Verdier), Dominique Maubon (CHU de Grenoble), Dominique Mazier (CHU Pitié-Salpêtrière, Paris), Dominique Popjora (CH Trousseau, Paris), Dominique Toubas (CHRU de Reims), Dorothée Quino (CHRU Morvan, Brest), Alioune Ndour (INTS, Paris), Ducout Louis (CH de la Côte Basque), Duong Thanh Hai (CHRU Bretonneau), E. Boyer (CH Le Mans), Edgar Ombandza (CH Provins), Edith Mazars (CH de Valenciennes), Elisabeth Buffet (CH de Epernay), Elodie Collin (CHI Robert Ballanger, Aulnay-sous-Bois), Elodie Meynet (CH Annecy Genevois), Emeline Scherer (CHU Besançon, Jean Minjoz), Emilie Fréalle (CH Lille), Emilie Klein (CHU Lariboisière, Paris), Emilie Sitterle (CHU Necker, Paris), Emily Ronez (CHU Lariboisière, Paris), Emmanuel Dutoit (CH Lille), Enrique Casalino (CHU Bichat-Claude Bernard, Paris), Eric Caumes (CHU Pitié-Salpêtrière, Paris), Eric Dannaoui (Hôpital Européen Georges Pompidou, Paris), Eric Gardien (CH de Draguignan, Bordeaux), Eric Kendjo (CHU Pitié-Salpêtrière, Paris),Eric d'Ortenzio (CHU Bichat-Claude Bernard, Paris), Ermanno Candolfi (CHU de Strasbourg), Estelle Perraud-Cateau (CH Poitiers), Eterne Twizeyimana (CH du Cotentin), F. Roblot (CH Poitiers), Fabienne Pateyron (CH Provins), Fabrice Bruneel (CH de Versailles, André Mignot), Fabrice Legros (CNR du paludisme), Fabrice Simon (HIA Laveran), Fakhri Jeddi (CHU Nantes), Farida M. Benaoudia (CH Troyes), Faïzi Ajana (CH Tourcoing), Felix Djossou (CH de Cayenne Andrée Rosemon), Firouze Banisadr (CHRU de Reims), Florent Morio (CHU Nantes), Francis Derouin (Hôpital Saint-Louis, Paris), Francois Moussel (CH François-Quesnay, Mantes-La-Jolie), Francoise Foulet (CHU Henri Mondor), François Peyron (Lyon-Croix-Rousse), Françoise Benoit-Vical (CHU Toulouse), Françoise Botterel (CHU Henri Mondor), Françoise Gayandrieu (CHU Nantes), Françoise Schmitt (CH du Moenchsberg, Mulhouse), Frederic Ariey (CHU Cochin, Paris), Frédéric Grenouillet (CHU Jean Minjoz, Besançon), Frédéric Sorge (CHU Necker), Frédérique Gay (CHU Pitié-Salpêtrière, Paris), Frédérique Foudrinier (CHRU de Reims), G. Courrouble (CH Blois), G. Gallou (CH de Falaise), G. Julienne (CH Belfort), G. Philippon (Centre Médical CMETE, Paris), Gauthier Pean-de-Ponfilly (CHU Lariboisière, Paris), Geneviève Grise (CH d’Elbeuf), Ghania Belkacem Belkadi (CH Tenon), Gilbert Lorre (CHD La Roche-sur-Yon), Gilles Gargala (CHU Rouen), Gilles Nevez (CHRU Morvan, Brest), Gisele Dewulf (CH de Valenciennes), Guillaume Désoubeaux (CHRU Bretonneau, Tours), Guillaume Escriou (CHU Bichat-Claude Bernard, Paris), Guillaume Le Loup (CH Tenon, Paris), Guillaume Menard (HIA Saint-Anne, Toulon), Guy Carroger (CH Jacques Cœur, Bourges), Guy Galeazzi (CH Louis Mourier), Gwénaël le Moal (CH Poitiers), Hana Talabani (CHU Cochin, Paris), Hanene Abid (CHU Necker, Paris), Helene Broutier (CHI Robert Ballanger, Aulnay-sous-Bois), Herve Pelloux (CHU de Grenoble), Houria Ichou (CH Louis Mourier), Hugo Laurent (CHU Lariboisière, Paris), Hélène Broutier (CH Meaux), Hélène Lapillonne (CH Trousseau, Paris), Hélène Yera (CHU Cochin, Paris), Hélène savini (HIA Laveran), I. Hermes (CH Saint-Malo), Ilhame Tantaoui (CHU Pitié-Salpêtrière, Paris), Isabelle Poilane (CH Bondy-Jean Verdier), Isabelle Amouroux (Hôpital Antoine-Béclère), Isabelle Mazurier (Hôpitaux Civils de Colmar), Isabelle Salimbeni (CH de Cannes), Isabelle Tawa (Centre Médical CMETE, Paris), J Cuziat (CH Saint-Nazaire), J. Bernard Poux (CH de Val d'Ariège - Foix), J. Heurtet (CH Beauvais), J. Rome (CH de Fougères), J. Truchot (CHU Lariboisière, Paris), J.M. Segalin (CHR Orleans), Jacques Gaillat (CH Annecy Genevois), Jacques Le bras (CHU Bichat-Claude Bernard, Paris), Jacques Thevenot (Centre Médical CMETE, Paris), Jacques Vaucel (CH Saint-Brieuc), Jean Dunand (Hôpital Ambroise Paré), Jean Benjamin Murat (CH de Roanne), Jean Marie Trapateau (CH Angoulême), Jean Yves Peltier (CHI Poissy-st-germain), Jean-Etienne Pilo (HIA Begin), Jean-Francois Magnaval (CHU Toulouse), Jean-François Faucher (CHU Jean Minjoz, Limoge), Jean-Paul Boutin (DESP Sud), Jean-Paul Couaillac (CH de Cahors), Jean-Philippe Breux (CH Cholet), Jean-Pierre Hurst (CH Jacques Monod, Le Havre), Jean-Yves Siriez (CHU Robert Debré, Paris), Jean-philippe Bouchara (CHU Angers), Jerome Clain (CHU Bichat-Claude Bernard, Paris), Jerome Naudin (CHU Robert Debré, Paris), Jordan Leroy (CH Lille), Josette Jehan (CH du Cotentin), Joudia Najid (CHU Pitié-Salpêtrière, Paris), Judith Gorlicki (CHU Lariboisière, Paris), Julie Bonhomme (CHU Côte de Nacre), Julie Brunet (CHU de Strasbourg), Jérome Guinard (CHR Orleans), Karima Cheikh (CHU Henri Mondor), L. Pougnet (HIA Clermont Tonnerre, Brest), Lauren Pull (CHU Robert Debré, Paris), Laurence Millon (CHU Jean Minjoz, Besançon), Laurence Campergue-Mayer (CH Avignon), Laurence Estepa (CH Blois), Laurence Lachaud (CHU Nîmes), Laurent Aaron (CH Jacques Cœur, Bourges), Laurent Bret (CHR Orléans), Laurent Guillaume (CH Blois), Liliane Ciceron (CHU Pitié-Salpêtrière, Paris), Lionnel Bertaux (CNR du paludisme), Lise Musset (Institut Pasteur, Guyane), Louise Basmacyan (CHU Dijon), Loïc Favennec (CHU Rouen), Luce Landraud (CH Louis Mourier), Lucile Cadot (CH Alès - Cévennes), Ludovic de Gentile (CHU Angers), Luis Macias (CHU Bichat-Claude Bernard, Paris), Luu-ly Pham (CHU Kremlin-Bicêtre, Paris), M. Cambon (CHRU Clermont-Ferrand), M.F. Biava (CHU de Nancy), M.H. Kiefer (CH du Moenchsberg), M.P. Carlotti (CNR du paludisme), Madeleine Fontrouge (CH de Gonesse), Marc Pihet (CHU Angers), Marc Thellier (CHU Pitié-Salpêtrière, Paris), Marie-Catherine Receveur (CHU de Bordeaux), Marie-Claire Machouart (CHU de Nancy), Marie-Elisabeth Bougnoux (CHU Necker, Paris), Marie-Laure Bigel (CH François-Quesnay, Mantes-la-Jolie), Marie-Laure Darde (CHU Dupuyrien, Limoges), Marie-Nadège Bachelier (CH Jacques Cœur, Bourges), Marion Almeras (CH Béziers), Marion Leterrier (CHU Nantes), Marion Leterrier (CHD La Roche-sur-Yon), Martin Danis (CHU Pitié-Salpêtrière, Paris), Martin G (CH du Cotentin), Martine Bloch (CH Louis Mourier), Martine Liance (CHU Henri Mondor, Paris), Marylin Madamet (IMTSSA, Marseille), Matthieu Revest (CHU Pontchaillou, Rennes),Matthieu Mechain (CHU de Bordeaux), Maxime Thouvenin (CH Troyes), Mermond Sylvain (Institut Pasteur, Nouméa), Michel Develoux (CH Tenon, Paris), Michel Miegeville (CHU Nantes), Milène Sasso (CHU Nîmes), Mohamed Diaby (CH Vernon), Monique Marty (CH La Rochelle), Monique Greze (CH Albi), Monique Lemoine (CHU Bichat-Claude Bernard, Paris), Mouri Oussama (CHU Pitié-Salpêtrière, Paris), Muriel Cornet (Hôpital Hôtel-Dieu, Paris), Muriel Mimoun Ayache (CH Trousseau), Muriel Nicolas (CHU Pointe-à-Pitre / Abymes), Muriel Roumier (CH Arles), Muriel Silva (CH Jacques Monod), Mylène Penot (CERBA), Myriam Gharbi (CHU Bichat-Claude Bernard, Paris), Nadia Guennouni (CHU Bichat-Claude Bernard, Paris), Nadine Godineau (Hôpital Delafontaine, Saint-Denis), Naima Dahane (CHU Cochin, Paris), Nathalie Bourgeois (CHU Montpellier), Nathalie Desuremain (CH Trousseau, Paris), Nathalie Fauchet (CHI de Créteil), Nathalie Parez (CH Louis Mourier), Nathalie Wilhelm (CH de Cahors), Nawel Ait-Ammar (Hôpital Ambroise Paré), Nayla Nassar (CH Auxerre), Nicolas Argy (CHU Bichat-Claude Bernard, Paris), Nicolas Blondiaux (CH Tourcoing), Nicolas Taudon (CERBA), Nicole Desbois-Nogard (CHU de la Martinique), Noura Hassouni (CHU Necker), Odile Bouret-Dubouis (CH Bretagne Atlantique), Odile Eloy (CH de Versailles, André Mignot), Odile Falguiere (CH Béziers), Odile Fenneteau (CHU Robert Debré, Paris), Olivia Bandin (Hôpital Saint-Camille/Bry-sur-Marne), Olivier Albert (CHU de Bordeaux), Olivier Bouchaud (CH Bobigny-Avicenne), Olivier Patey (CHI Villeneuve St. Georges), Olivier Rogeaux (CH Chambéry), P. Clergeau (CH Sallanches), P. Daumain (CH de Dourdan), P.H. Consigny (Institut Pasteur, Paris), Paméla Chauvin (CHU Toulouse), Pascal Delaunay (CH Universitaire de Nice), Pascal Hazera (CH Saint-Lo), Pascal Houze (Hôpital Saint Louis, Paris), Pascal Millet (CHU de Bordeaux), Pascal Pouedras (CH Bretagne Atlantique), Pascale Penn (CH Le Mans), Patrice Agnamey (CHU Amiens), Patrice Bourrée (CHU Kremlin-Bicêtre, Paris), Patricia Barbut (CH Longjumeau), Patricia Brugel (CH Antibes Juan-Les-Pins), Patricia Roux (CH Saint-Antoine, Paris), Patrick Leguen (HIA Clermont Tonnerre, Brest), Patrick Valayer (CH Notre-Dame de la Miséricorde), Pauline Caraux-Paz (CHI Villeneuve St Georges), Pauline Touroultjupin (CH Cholet), Philippe Abboud (CHU Rouen), Philippe Cormier (CH d’Evry), Philippe Minodier (CH Marseille Nord), Philippe Moskovtchenko (Hôpitaux Civils de Colmar), Philippe Parola (CH Marseille Nord), Philippe Poirier (CHRU Clermont-Ferrand), Philippe Stolidi (CH Aubagne), Pierre Patoz (CH Tourcoing), Pierre Buffet (INTS, Paris), Pierre Buffet (CHU Pitié-Salpêtrière, Paris), Pierre Flori (CH Saint-Etienne), Pierre Marty (CH Universitaire de Nice), Pierre Mornand (CH Trousseau, Paris), Pinel Claudine (CHU de Grenoble), R. Dahan (CHU de Strasbourg), R. Devallière (CH Saint-Nazaire), R. Mazataud (CH Vitry le François), Rahaf Haj Hamid (CH Louis Mourier), Regis Courtin (CHU Pitié-Salpêtrière, Paris), Renaud Blonde (CHU Robert Debré, Paris), René Nabias (CHI Poissy-st-germain), Roland Fabre (HIA Begin), Rose-Anne Lavergne (CHU Nantes), Roxane Courtois (CH Cholet), Rym Chouk Turki (CHU Henri Mondor), Rémy Durand (CH Bobigny-Avicenne), Réné Nabias (CHU Necker, Paris), Sabah Kubab (CH Corbeil Essonne), Sabine Lasserre (CH Trousseau, Paris), Samia Hamane (Hôpital Saint-Louis, Paris), Sandrine Cojean (CHU Bichat-Claude Bernard, Paris), Sandrine Houze (CHU Bichat-Claude Bernard, Paris), Sophie Matheron (CHU Bichat-Claude Bernard, Paris), Sorya Belaz (CHU Pontchaillou, Rennes), Stephane Jaureguiberry (CHU Pitié-Salpêtrière, Paris), Stephane Ranque (CH de la Timone, Marseille), Stephanie Dulucq (CHU de Bordeaux), Stéphane Bretagne (Hôpital Saint-Louis, Paris), Stéphane Pelleau (Institut Pasteur, Guyane), Stéphane Picot (Hospices Civils de Lyon), Sylvain Clauser (Hôpital Ambroise Paré), Sylviane Chevrier (CHU Pontchaillou, Rennes), Sylviane Dydymski (CHRU Clermont-Ferrand), Sylvie Lariven (CHU Bichat-Claude Bernard, Paris), Sylvie Lhopital (CH Vernon), Sylvie Maurellet Evrard (CHI Villeneuve St Georges), Sylvie Roulaud (CH Angouleme), Sébastien Larréché (HIA Begin), Thi-Hai-Chau Trinh (CHR Orléans), Thierry Ancelle (CHU Cochin, Paris), Thierry Pistone (CHU de Bordeaux), Thomas Hanslik (Hôpital Ambroise Paré), Thomas Guimard (CHD La Roche-sur-Yon), Timothée Klopfenstein (CHU Besançon, Jean Minjoz), Valerie Fuster-Dumas (CHU de Bordeaux), Veronique Blanc-Amrane (CH Antibes Juan-Les-Pins), Veronique Delcey (CHU Lariboisière, Paris), Veronique Sarrasin-Hubert (CHU Bichat-Claude Bernard, Paris), Vincent Foissaud (HIA Percy, Clamart), Virginie Mouton-Rioux (CH Bretagne Atlantique), Virginie Vitrat (CH Annecy Genevois), Véronique Jan-Lasserre (CH Lagny-sur-Marne), Xavier Nicolas (HIA Clermont Tonnerre, Brest), Y. Costa (CH Lagny-sur-Marne), Yassamine Lazrek (Institut Pasteur, Guyane), Yaye Senghor (Hôpital Saint Joseph, Paris), Yohann Le Govic (CHU Angers), Yves Guimard (CH Jacques Cœur, Bourges), Yves Poinsignon (CH Bretagne Atlantique), Claude flamand (Institut Pasteur, Guyane), C.N. guyen (CH Trousseau, Paris), G. Noël (CH Marseille Nord), G. Soula (CH Marseille Nord), J.M.Didier (CH Vesoul), M.F. Raynaud (CH Antibes Juan-Les-Pins), M. Julien (CH Béziers), M. Morillon (HIA Laveran), M.P. Carlotti (IMTSSA), P. Chantelat (CH Vesoul), P. Dussert (CH Belfort), P. Ralaimazava (CH Bobigny-Avicenne), S. Zaouche (CHU Necker, Paris), Élodie Lesteven (CHU Lariboisière, Paris)., Musset, Lise, Centre National de Référence du Paludisme [CHU Pitié-Salpétrière] (CNRpalu), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Plasmodium, Epidemiology, FNRCm, MESH: Hospitalization, Mark and recapture, 0302 clinical medicine, MESH: Aged, 80 and over, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Child, 030212 general & internal medicine, MESH: Incidence, MESH: Travel, Imported malaria, media_common, MESH: Aged, MESH: Middle Aged, MESH: Infant, 3. Good health, MESH: Young Adult, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, surveillance, France, Sex ratio, MESH: Medical Record Linkage, MESH: Disease Notification, 030231 tropical medicine, Notifiable disease, MESH: Malaria, capture-recapture, malaria, MESH: Population Surveillance, 03 medical and health sciences, MESH: Cross-Sectional Studies, Virology, parasitic diseases, medicine, media_common.cataloged_instance, European union, MESH: Communicable Diseases, Imported, MESH: Adolescent, MESH: Hospitals, University, MESH: Humans, business.industry, MESH: Child, Preschool, Public Health, Environmental and Occupational Health, MESH: Adult, medicine.disease, Confidence interval, MESH: Male, Metropolitan France, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, travellers, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Malaria, Demography
Abstract

Introduction Malaria is a notifiable disease in all European Union and European Economic Area countries except Belgium and France, where only autochthonous malaria is notifiable. Although morbidity caused by malaria has been assessed, little is known about mortality incidence. Objective Our aim was to estimate the number of imported malaria-related deaths in hospital in metropolitan France. Methods We matched individual deaths reported between 1 January 2005 and 31 December 2014 to the French National Reference Centre for malaria (FNRCm) with malaria-related deaths from two other sources: the French National Registry on medical causes of death and the French national hospital discharge database. A capture–recapture method with log-linear modelling was used. Age, sex and place of death stratification were applied to remove heterogeneity. Results The estimated malaria-related deaths in metropolitan France during the study period were 205 (95% confidence interval (CI): 191–219). The annual mean number of malaria-related deaths was estimated at 21 (95% CI: 19–22). The FNRCm malaria-related deaths surveillance had a 38% sensitivity (95% CI: 32–44). Among 161 in-hospital individual malaria-related deaths reported from three data sources, the sex ratio (male to female) was 2.6. Median age of the patients was 57 years, ranging from 1 to 89 years. Conclusion The pertinent finding of this report is that malaria-related death records were significantly less* complete than case records. Therefore, data comparison of imported malaria morbidity and mortality between countries should imperatively be assessed using standard indicators weighted according to the completeness of health surveillance systems.

Published
2020

24. Le rôle des formes infracliniques dans l’émergence des infections vectorielles ? L'apport des investigations de terrain

Author

Noël, Harold, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Université Paris Saclay (COmUE), and Jean-Claude Desenclos

Subjects
Emerging infections, Santé publique fondée sur la preuve, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Epidemiologic surveillance, Investigation d'épidémie, Epidemiology, Outbreak investigation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Infections émergentes, Epidémiologie, Evidenced-Based public health
Abstract

Conditions recently proved favourable to transmission of emerging vector-borne diseases, chikungunya, dengue and urogenital schistosomiasis in mainland France.Santé publique France, the Agency in charge of public health surveillance in France is at the forefront of detecting and investigating emerging infectious disease in order to guide prevention and control measures. Assuming that each outbreak constitutes a situation of "natural experimentation", the aim of this thesis was to show how outbreak investigations give the opportunity to acquire rapidly scientific knowledge on the contribution of asymptomatic cases to the introduction, dissemination and endemisation of vector-borne diseases.Through a meta-analysis of per and post-epidemic seroprevalence studies,we have shown that the chikungunya virus lineage that emerged in the Indian Ocean in 2004 is associated with a lower frequency of asymptomatic infections. In a dengue serosurvey in Nîmes in 2015, we showed that the diffusion potential of dengue in France is currently limited. Screening data of urogenital bilharziasis in persons exposed in Corsica showed a high frequency of pre-symptomatic infections suggestive of a risk of endemisation of the disease that justified its inclusion on the list of notifiable diseases.This thesis work shows that a pragmatic approach based on sensitive surveillance associated with early field outbreak investigations can significantly contribute to both emerging infections control and the advancement of knowledge.; Le chikungunya, la dengue et la bilharziose urogénitale sont des maladies vectorielles émergentes qui ont récemment trouvé des conditions favorables à leur transmission en France métropolitaine.Santé publique France, l’Agence en charge de la surveillance de l’état de santé de la population française est en première ligne pour détecter et investiguer ces émergences afin d’orienter les mesures de leur prévention et de leur contrôle. Postulant que chaque épidémie constitue une situation d’« expérimentation naturelle », l’objectif de cette thèse était de montrer comment chaque investigation d’épidémie apporte l’opportunité d’acquérir des connaissances scientifiques sur la contribution des cas asymptomatiques à l’introduction, la dissémination et l’endémisation des maladies vectorielles de façon réactive.Notre méta-analyse d’études de séroprévalence per- et post-épidémiques suggère que, contrairement à nos attentes, la lignée de virus chikungunya qui a émergé en 2004 dans l’Océan Indien qui était associée moins d’infections asymptomatiques que les autres. Dans une étude de la séroprévalence de la dengue à Nîmes en 2015, nous avons montré que le potentiel de diffusion de la dengue en France restait actuellement limité. Les données du dépistage des personnes exposées au risque de bilharziose urogénitale en Corse montrant une fréquence élevée d'infections pré-symptomatiques, nous avons évoqué un risque d’endémisation de la maladie qui a justifié son inscription sur la liste des maladies à déclaration obligatoire.Ce travail de thèse démontre qu’une approche pragmatique basée sur une veille sanitaire sensible associée à des investigations épidémiologiques de terrain précoces peut contribuer à aussi bien à la lutte contre les émergences qu’à l’évolution des connaissances.

Published
2019

25. Role of Subclinical Forms in the Emergence of Vector-Borne Infections ? Contribution of Field Investigations

Author

Noël, Harold, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Université Paris Saclay (COmUE), Jean-Claude Desenclos, and STAR, ABES

Subjects
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Emerging infections, Santé publique fondée sur la preuve, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Epidemiologic surveillance, Investigation d'épidémie, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Epidemiology, Outbreak investigation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Infections émergentes, Epidémiologie, Evidenced-Based public health
Abstract

Conditions recently proved favourable to transmission of emerging vector-borne diseases, chikungunya, dengue and urogenital schistosomiasis in mainland France.Santé publique France, the Agency in charge of public health surveillance in France is at the forefront of detecting and investigating emerging infectious disease in order to guide prevention and control measures. Assuming that each outbreak constitutes a situation of "natural experimentation", the aim of this thesis was to show how outbreak investigations give the opportunity to acquire rapidly scientific knowledge on the contribution of asymptomatic cases to the introduction, dissemination and endemisation of vector-borne diseases.Through a meta-analysis of per and post-epidemic seroprevalence studies,we have shown that the chikungunya virus lineage that emerged in the Indian Ocean in 2004 is associated with a lower frequency of asymptomatic infections. In a dengue serosurvey in Nîmes in 2015, we showed that the diffusion potential of dengue in France is currently limited. Screening data of urogenital bilharziasis in persons exposed in Corsica showed a high frequency of pre-symptomatic infections suggestive of a risk of endemisation of the disease that justified its inclusion on the list of notifiable diseases.This thesis work shows that a pragmatic approach based on sensitive surveillance associated with early field outbreak investigations can significantly contribute to both emerging infections control and the advancement of knowledge., Le chikungunya, la dengue et la bilharziose urogénitale sont des maladies vectorielles émergentes qui ont récemment trouvé des conditions favorables à leur transmission en France métropolitaine.Santé publique France, l’Agence en charge de la surveillance de l’état de santé de la population française est en première ligne pour détecter et investiguer ces émergences afin d’orienter les mesures de leur prévention et de leur contrôle. Postulant que chaque épidémie constitue une situation d’« expérimentation naturelle », l’objectif de cette thèse était de montrer comment chaque investigation d’épidémie apporte l’opportunité d’acquérir des connaissances scientifiques sur la contribution des cas asymptomatiques à l’introduction, la dissémination et l’endémisation des maladies vectorielles de façon réactive.Notre méta-analyse d’études de séroprévalence per- et post-épidémiques suggère que, contrairement à nos attentes, la lignée de virus chikungunya qui a émergé en 2004 dans l’Océan Indien qui était associée moins d’infections asymptomatiques que les autres. Dans une étude de la séroprévalence de la dengue à Nîmes en 2015, nous avons montré que le potentiel de diffusion de la dengue en France restait actuellement limité. Les données du dépistage des personnes exposées au risque de bilharziose urogénitale en Corse montrant une fréquence élevée d'infections pré-symptomatiques, nous avons évoqué un risque d’endémisation de la maladie qui a justifié son inscription sur la liste des maladies à déclaration obligatoire.Ce travail de thèse démontre qu’une approche pragmatique basée sur une veille sanitaire sensible associée à des investigations épidémiologiques de terrain précoces peut contribuer à aussi bien à la lutte contre les émergences qu’à l’évolution des connaissances.

Published
2019

27. Vector-borne transmission of Zika virus in Europe, southern France, August 2019

Author

Giron, Sandra, primary, Franke, Florian, additional, Decoppet, Anne, additional, Cadiou, Bernard, additional, Travaglini, Thierry, additional, Thirion, Laurence, additional, Durand, Guillaume, additional, Jeannin, Charles, additional, L’Ambert, Grégory, additional, Grard, Gilda, additional, Noël, Harold, additional, Fournet, Nelly, additional, Auzet-Caillaud, Michelle, additional, Zandotti, Christine, additional, Aboukaïs, Samer, additional, Chaud, Pascal, additional, Guedj, Saby, additional, Hamouda, Lakri, additional, Naudot, Xavier, additional, Ovize, Anne, additional, Lazarus, Clément, additional, de Valk, Henriette, additional, Paty, Marie-Claire, additional, and Leparc-Goffart, Isabelle, additional

Published
2019
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28. The Medieval Consolation of Philosophy : An Annotated Bibliography

Author

Noel Harold Kaylor, Jr and Noel Harold Kaylor, Jr

Subjects
Philosophy, Medieval--Bibliography, Philosophy and religion--Early works to 1800--Bibliography, Happiness--Early works to 1800--Bibliography
Abstract

Originally published in 1992 The Medieval Consolation of Philosophy is an annotated bibliography looking at the scholarship generated by the translations of the works of Boethius. The book looks at translations which were produced in medieval England, France, and Germany and addresses the influence exercised by Boethius, which extended into almost every area of medieval intellectual and artistic life. The book acts in two ways, as a whole the book acts as a bibliography and study of the European tradition of Consolatio translations, but viewed on a chapter-by-chapter basis, it is a collection of independent bibliographies on the individual vernacular traditions. The book contains separate chapters looking at the Consolatio traditions of medieval France and Germany.

Published
2020

31. Dengue serosurvey after a 2-month long outbreak in Nîmes, France, 2015: was there more than met the eye?

Author

Succo, Tiphanie, primary, Noël, Harold, additional, Nikolay, Birgit, additional, Maquart, Marianne, additional, Cochet, Amandine, additional, Leparc-Goffart, Isabelle, additional, Catelinois, Olivier, additional, Salje, Henrik, additional, Pelat, Camille, additional, de Crouy-Chanel, Perrine, additional, de Valk, Henriette, additional, Cauchemez, Simon, additional, and Rousseau, Cyril, additional

Published
2018
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32. Persistence of schistosomal transmission linked to the Cavu river in southern Corsica since 2013

Author

Ramalli, Lauriane, primary, Mulero, Stephen, additional, Noël, Harold, additional, Chiappini, Jean-Dominique, additional, Vincent, Josselin, additional, Barré-Cardi, Hélène, additional, Malfait, Philippe, additional, Normand, Guillaume, additional, Busato, Florian, additional, Gendrin, Vincent, additional, Allienne, Jean-François, additional, Fillaux, Judith, additional, Boissier, Jérôme, additional, and Berry, Antoine, additional

Published
2018
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36. Preliminary report of an autochthonous chikungunya outbreak in France, July to September 2017

Author

Calba, Clémentine, primary, Guerbois-Galla, Mathilde, additional, Franke, Florian, additional, Jeannin, Charles, additional, Auzet-Caillaud, Michelle, additional, Grard, Gilda, additional, Pigaglio, Lucette, additional, Decoppet, Anne, additional, Weicherding, Joel, additional, Savaill, Marie-Christine, additional, Munoz-Riviero, Manuel, additional, Chaud, Pascal, additional, Cadiou, Bernard, additional, Ramalli, Lauriane, additional, Fournier, Pierre, additional, Noël, Harold, additional, De Lamballerie, Xavier, additional, Paty, Marie-Claire, additional, and Leparc-Goffart, Isabelle, additional

Published
2017
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37. Re-emergence of urinary schistosomiasis in Europe ? Infections acquired in Southern Corsica – Investigation of a cluster of Schistosoma haematobium infections in 2014

Author

L. Ramalli, Noël, Harold, Ruello, Marc, Maccary, A., Boissier, Jerome, Barré-Cardi, Hélène, Fillaux, Judith, Termignon, J.L., Debruyne, Monique, Chyderiotis, G., Denoyel, G.A., T. Succo, A. Armengaud, M.-C. Paty, Heuzé, Guillaume, Mattei, J., Théron, André, and Berry, Antoine

Published
2015
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38. A Companion to Boethius in the Middle Ages

Author

Noel Harold Kaylor, Philip Edward Phillips, Noel Harold Kaylor, and Philip Edward Phillips

Subjects
Philosophy, Medieval
Abstract

The articles in this volume focus upon Boethius's extant works: his De arithmetica and a fragmentary De musica, his translations and commentaries on logic, his five theological texts, and, of course, his Consolation of Philosophy. They examine the effects that Boethian thought has exercised upon the learning of later generations of scholars--including, to a degree, scholars of the 21st century. The field of Boethian Studies has enjoyed a continuous history of works that treat either the entire Boethian tradition or major aspects of it. This volume offers a comprehensive study, and its construction is systematic, considering Boethius's works both as central to the disciplines that they represent and to the areas of scholarly interest that they influenced, and it is framed by articles on the historical contexts in which those works were produced.Contributors include: Noel Harold Kaylor, Jr., Stephen McCluskey, Rosalind C. Love, Jean-Yves Guillaumin, Siobhan Nash-Marshall, John Casey, Paul E. Szarmach, Christine Hehle, Glynnis M. Cropp, Dario Bancato, Ian Johnson, Mark T. Rimple, Ann E. Moyer, Fabio Troncarelli, and Philip Edward Phillips.

Published
2012

45. Outbreak of Shiga Toxin–Producing Escherichia coli O104:H4 Associated With Organic Fenugreek Sprouts, France, June 2011.

Author

King, Lisa A., Nogareda, Francisco, Weill, François-Xavier, Mariani-Kurkdjian, Patricia, Loukiadis, Estelle, Gault, Gaëlle, Jourdan-DaSilva, Nathalie, Bingen, Edouard, Macé, Muriel, Thevenot, Delphine, Ong, Nathalie, Castor, Christine, Noël, Harold, Van Cauteren, Dieter, Charron, Martine, Vaillant, Véronique, Aldabe, Benedicte, Goulet, Véronique, Delmas, Gilles, and Couturier, Elisabeth

Subjects
DISEASE outbreaks, VEROCYTOTOXINS, ESCHERICHIA coli, FENUGREEK, HEMOLYTIC-uremic syndrome, CONFIDENCE intervals
Abstract

We report the investigation of a point-source Shiga toxin–producing Escherichia coli O104:H4 outbreak during a large European outbreak in 2011. Confrontation of French and German outbreak investigation results identified a common food vehicle, fenugreek sprouts, and producer and resulted in Europe-wide control measures.Background. On 22 June 2011, 8 patients with hemolytic uremic syndrome (HUS) or bloody diarrhea were reported in France. All 8 were attendees of a community center event on 8 June near Bordeaux. Three Escherichia coli cases were confirmed by isolation of Shiga toxin–producing E. coli O104:H4 stx2 aggR producing a cefotaximase (CTX-M) β-lactamase (STEC O104:H4); the same rare serotype caused the outbreak in Germany in May–July 2011. An investigation was initiated to describe the outbreak, identify the vehicle for infection, and guide control measures.Methods. We conducted a retrospective cohort study among all adults attending the event, including food handlers. A standardized questionnaire was administered to participants. A case was an attendee who developed HUS or diarrhea between 8 and 24 June. Cases were confirmed by isolation of STEC O104:H4 or O104 serology. Relative risks (RRs) and 95% confidence intervals (CIs) by exposure were calculated using a Poisson regression model.Results. Twenty-four cases were identified (14% attack rate). Of these, 18 (75%) were women, 22 (92%) were adults, 7 (29%) developed HUS, 5 (21%) developed bloody diarrhea, and 12 (50%) developed diarrhea. Ten (42%) cases were confirmed. Fenugreek was the only sprout type with an independent association to illness (RR, 5.1; 95% CI, 2.3–11.1) in multivariable analysis.Conclusions. This investigation identified a point-source STEC O104:H4 outbreak associated with consumption of fenugreek sprouts. Comparison of results from French and German STEC O104:H4 outbreak investigations enabled identification of a common food vehicle, fenugreek sprouts, and resulted in implementation of Europe-wide control measures in July 2011. [ABSTRACT FROM AUTHOR]

Published
2012
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46. History of smallpox vaccination and marked clinical expression of mpox among cases notified in France from May to July 2022.

Author

Krug, Catarina, Chazelle, Emilie, Tarantola, Arnaud, Noël, Harold, Spaccaferri, Guillaume, Parent du Châtelet, Isabelle, Zanetti, Laura, Lahbib, Hana, Fayad, Myriam, Lot, Florence, De Valk, Henriette, Che, Didier, Coignard, Bruno, Mailles, Alexandra, and Barret, Anne-Sophie

Subjects
*SMALLPOX vaccines, *MONKEYPOX, *VACCINATION status, *VACCINATION complications, *VACCINATION of children
Abstract

The aim was to estimate the effect of reported history of smallpox vaccination prior to 1980 on clinical expression of mpox. We included all confirmed mpox cases identified by the national mpox surveillance system in France between May and July 2022. Cases tested positive for monkeypox virus or orthopoxviruses by PCR. Cases were interviewed by phone using a questionnaire documenting demographics, symptoms and exposures. To estimate the effect of smallpox vaccination on the presence of marked mpox symptoms (association of fever, lymphadenopathy and extensive mucocutaneous lesions), we estimated prevalence ratios (PRs) and 95% CIs using Poisson regression models with robust standard errors. There were 1888 confirmed mpox cases with date of symptom onset between 7 May and 31 July 2022. Overall, 7% (93/1394) presented marked mpox symptoms. Among patients who provided information about their vaccination status, 14% (207/1469) reported smallpox vaccination prior to 1980. The proportion of cases with marked symptoms was 2% (3/170) among those reporting smallpox vaccination prior to 1980 and 8% (76/974) among those who reported no vaccination. The proportion of marked symptoms was four times lower among cases reporting previous smallpox vaccination than in cases reporting no vaccination (PR, 0.24; 95% CI: 0.08–0.76). There was no evidence of an effect of smallpox vaccination on development of complications (PR, 0.65; 95% CI: 0.35–1.22) or hospitalization due to mpox (PR, 0.64; 95% CI: 0.23–1.80). Our results suggest that smallpox vaccination during childhood attenuated the clinical expression of monkeypox virus infection, but there was no evidence of an effect on complications or hospitalization. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Consumption of Fresh Fruit Juice: How a Healthy Food Practice Caused a National Outbreak of SalmonellaPanama Gastroenteritis

Author

Noël, Harold, Hofhuis, Agnetha, De Jonge, Rob, Heuvelink, Annet E., De Jong, Aarieke, Heck, Max E.O.C., De Jager, Carolien, and van Pelt, Wilfrid

Abstract

AbstractIn spring 2008, 15 SalmonellaPanama laboratory-confirmed cases were reported within 2 weeks, twice the average annual number of reported cases of this infrequent serotype in The Netherlands. To identify the source responsible for this national outbreak, we carried out an epidemiological, microbiological, and trace-back investigation. In total, 33 cases were reported, and a matched case–control study (23 cases/24 controls) identified consumption of fresh (unpasteurized) fruit juice purchased from a large retailer (X) as the only significant risk factor for illness (matched odds ratio: 7.4, 95% confidence interval: 1.5–37.2). Though the bacterium could not be isolated from fruit juice, the minimal pH value for growth of the causative strain of the outbreak (3.4) was compatible with survival in fruit juice from X. The outbreak strain showed acid resistance and adaptive properties that may explain how it could have caused infection through fresh orange juice. To our knowledge, this is the first documented outbreak related to fresh fruit juice consumption in western Europe since 1922. A growing number of consumers who are seeking healthy food practices are exposed to the infectious risks related to unpasteurized fresh fruit juice. Labeling regulations should be adapted to properly indicate to the consumers that unpasteurized fresh fruit juices remain vulnerable to microbial contamination. Frequent microbiological screening and strict compliance with food safety procedures should reduce the infectious hazards of fresh fruit juices.

Published
2010
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48. Dengue serosurvey after a 2-month long outbreak in Nîmes, France, 2015: was there more than met the eye?

Author

Succo, Tiphanie, Noël, Harold, Nikolay, Birgit, Maquart, Marianne, Cochet, Amandine, Leparc-Goffart, Isabelle, Catelinois, Olivier, Salje, Henrik, Pelat, Camille, De Crouy-Chanel, Perrine, De Valk, Henriette, Cauchemez, Simon, and Rousseau, Cyril

Subjects
Male, Spatial Analysis, viruses, virus diseases, Mosquito Vectors, Dengue Virus, 3. Good health, Dengue outbreak – Seroprevalence – Transmission risk – Aedes albopictus – Europe/France – West Nile virus, Disease Outbreaks, Dengue, Aedes, Seroepidemiologic Studies, Prevalence, Animals, Humans, Female, France
Abstract

BackgroundClusters of dengue cases have recently become more frequent in areas of southern France colonised by the vector mosquito Aedes albopictus. In July 2015, a 2-month outbreak of dengue virus serotype 1 (DENV-1) was reported in Nîmes. Aim: We conducted a serosurvey in the affected area at the end of the vector activity period to determine the true extent of dengue transmission. Methods: We collected capillary blood from consenting household members, and information on their medical and travel histories, and exposure to mosquito bites. Recent infections were identified using IgM and IgG anti-DENV ELISA, followed, when positive, by plaque reduction neutralisation tests on serum against DENV 1-4 and West Nile virus. The prevalence estimator was calibrated on reference demographic data. We quantified the spatial clustering of dengue cases within the affected community and inferred the transmission tree. Results: The study participation rate was 39% (564/1,431). Three of 564 participants tested positive for DENV-1 infection (after marginal calibration, 0.41%; 95% confidence interval: 0.00-0.84). The spatial analysis showed that cases were clustered at the household level. Most participants perceived the presence of mosquitos as abundant (83%) and reported frequent mosquito bites (57%). We incidentally identified six past West Nile virus infections (0.9%; 95% CI: 0.2-1.6). Conclusion: This serosurvey confirms the potential for arboviral diseases to cause outbreaks - albeit limited for now - in France and Europe.

49. Genomic analysis of Vibrio cholerae O1 isolates from cholera cases, Europe, 2022.

Author

Rouard C, Greig DR, Tauhid T, Dupke S, Njamkepo E, Amato E, van der Putten B, Naseer U, Blaschitz M, Mandilara GD, Cohen Stuart J, Indra A, Noël H, Sideroglou T, Heger F, van den Beld M, Wester AL, Quilici ML, Scholz HC, Fröding I, Jenkins C, and Weill FX

Subjects
Humans, Europe epidemiology, Whole Genome Sequencing, Microbial Sensitivity Tests, Genome, Bacterial, Genomics, Virulence genetics, Drug Resistance, Bacterial genetics, Vibrio cholerae O1 genetics, Vibrio cholerae O1 isolation & purification, Vibrio cholerae O1 classification, Cholera microbiology, Cholera epidemiology, Phylogeny, Anti-Bacterial Agents pharmacology
Abstract

BackgroundThe number of cholera cases reported to the World Health Organization (WHO) in 2022 was more than double that of 2021. Nine countries of the WHO European Region reported 51 cases of cholera in 2022 vs five reported cases in 2021.AimWe aimed to confirm that the Vibrio cholerae O1 isolates reported by WHO European Region countries in 2022 belonged to the seventh pandemic El Tor lineage (7PET). We also studied their virulence, antimicrobial resistance (AMR) determinants and phylogenetic relationships.MethodsWe used microbial genomics to study the 49 V. cholerae O1 isolates recovered from the 51 European cases. We also used > 1,450 publicly available 7PET genomes to provide a global phylogenetic context for these 49 isolates.ResultsAll 46 good-quality genomes obtained belonged to the 7PET lineage. All but two isolates belonged to genomic Wave 3 and were grouped within three sub-lineages, one of which, Pre-AFR15, predominated (34/44). This sub-lineage, corresponding to isolates from several countries in Southern Asia, the Middle East and Eastern or Southern Africa, was probably a major contributor to the global upsurge of cholera cases in 2022. No unusual AMR profiles were inferred from analysis of the AMR gene content of the 46 genomes.ConclusionReference laboratories in high-income countries should use whole genome sequencing to assign V. cholerae O1 isolates formally to the 7PET or non-epidemic lineages. Periodic collaborative genomic studies based on isolates from travellers can provide useful information on the circulating strains and their evolution, particularly as concerns AMR.

Published
2024
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50. Outbreak of Vibrio cholerae , Mayotte, France, April to July 2024.

Author

Mazzilli S, Youssouf H, Durand J, Soler M, Cholin T, Herry F, Collet L, Jean M, Ransay-Colle M, Benoit-Cattin T, Rouard C, Figoni J, Noël H, Piarroux R, and Lapostolle A

Subjects
Humans, France epidemiology, Adult, Middle Aged, Male, Adolescent, Female, Child, Aged, Drinking Water microbiology, Child, Preschool, Young Adult, Infant, Sanitation, Disease Outbreaks, Cholera epidemiology, Vibrio cholerae isolation & purification
Abstract

On 22 April 2024, a locally-acquired case of cholera was confirmed in Mayotte. Subsequently, local transmission resulted in eight outbreak clusters with 221 notified cases in densely populated neighbourhoods with limited or no access to drinking water. The last case was detected on 12 July. A case-area targeted intervention strategy was applied to contain the outbreak. However, improving access to drinking water and basic sanitation is crucial to prevent further exposure.

Published
2024
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