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1. GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Author

Lagou, Vasiliki, Jiang, Longda, Ulrich, Anna, Zudina, Liudmila, González, Karla Sofia Gutiérrez, Balkhiyarova, Zhanna, Faggian, Alessia, Maina, Jared G., Chen, Shiqian, Todorov, Petar V., Sharapov, Sodbo, David, Alessia, Marullo, Letizia, Mägi, Reedik, Rujan, Roxana-Maria, Ahlqvist, Emma, Thorleifsson, Gudmar, Gao, Ηe, Εvangelou, Εvangelos, Benyamin, Beben, Scott, Robert A., Isaacs, Aaron, Zhao, Jing Hua, Willems, Sara M., Johnson, Toby, Gieger, Christian, Grallert, Harald, Meisinger, Christa, Müller-Nurasyid, Martina, Strawbridge, Rona J., Goel, Anuj, Rybin, Denis, Albrecht, Eva, Jackson, Anne U., Stringham, Heather M., Corrêa, Jr., Ivan R., Farber-Eger, Eric, Steinthorsdottir, Valgerdur, Uitterlinden, André G., Munroe, Patricia B., Brown, Morris J., Schmidberger, Julian, Holmen, Oddgeir, Thorand, Barbara, Hveem, Kristian, Wilsgaard, Tom, Mohlke, Karen L., Wang, Zhe, Shmeliov, Aleksey, den Hoed, Marcel, Loos, Ruth J. F., Kratzer, Wolfgang, Haenle, Mark, Koenig, Wolfgang, Boehm, Bernhard O., Tan, Tricia M., Tomas, Alejandra, Salem, Victoria, Barroso, Inês, Tuomilehto, Jaakko, Boehnke, Michael, Florez, Jose C., Hamsten, Anders, Watkins, Hugh, Njølstad, Inger, Wichmann, H.-Erich, Caulfield, Mark J., Khaw, Kay-Tee, van Duijn, Cornelia M., Hofman, Albert, Wareham, Nicholas J., Langenberg, Claudia, Whitfield, John B., Martin, Nicholas G., Montgomery, Grant, Scapoli, Chiara, Tzoulaki, Ioanna, Elliott, Paul, Thorsteinsdottir, Unnur, Stefansson, Kari, Brittain, Evan L., McCarthy, Mark I., Froguel, Philippe, Sexton, Patrick M., Wootten, Denise, Groop, Leif, Dupuis, Josée, Meigs, James B., Deganutti, Giuseppe, Demirkan, Ayse, Pers, Tune H., Reynolds, Christopher A., Aulchenko, Yurii S., Kaakinen, Marika A., Jones, Ben, and Prokopenko, Inga

Published
2023
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9. Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins

Author

Solomon, Terry, Smith, Erin N, Matsui, Hiroko, Braekkan, Sigrid K, Wilsgaard, Tom, Njølstad, Inger, Mathiesen, Ellisiv B, Hansen, John-Bjarne, and Frazer, Kelly A

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Genetics, Cardiovascular, Biotechnology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Blood Proteins, Case-Control Studies, Computational Biology, Databases, Genetic, Exons, Gene Frequency, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Humans, Natriuretic Peptide, Brain, Norway, Phenotype, Prospective Studies, Protein Precursors, Quantitative Trait Loci, Risk Factors, Venous Thromboembolism, biomarker, coronary artery disease, exome, human, protein, venous thromboembolism, INVENT Consortium, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundGenetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated with diseases and physiological phenotypes.Methods and resultsAs part of a larger case-control study of venous thromboembolism, serum levels of 51 proteins implicated in cardiovascular diseases were measured in 330 individuals from the Tromsø Study. Exonic genetic variation near each protein's respective gene (cis) was identified using sequencing and arrays. Using single site and gene-based tests, we identified 27 genetic associations between pQTLs and the serum levels of 20 proteins: 14 associated with common variation in cis, of which 6 are novel (ie, not previously reported); 7 associations with rare variants in cis, of which 4 are novel; and 6 associations in trans. Of the 20 proteins, 15 were associated with single sites and 7 with rare variants. cis-pQTLs for kallikrein and F12 also show trans associations for proteins (uPAR, kininogen) known to be cleaved by kallikrein and with NTproBNP. We experimentally demonstrate that kallikrein can cleave proBNP (NTproBNP precursor) in vitro. Nine of the pQTLs have previously identified associations with 17 disease and physiological phenotypes.ConclusionsWe have identified cis and trans genetic variation associated with the serum levels of 20 proteins and utilized these pQTLs to study molecular mechanisms underlying disease and physiological phenotypes.

Published
2016

10. Associations Between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study.

Author

Solomon, Terry, Smith, Erin N, Matsui, Hiroko, Braekkan, Sigrid K, INVENT Consortium, Wilsgaard, Tom, Njølstad, Inger, Mathiesen, Ellisiv B, Hansen, John-Bjarne, and Frazer, Kelly A

Subjects
INVENT Consortium, Humans, Genetic Predisposition to Disease, Natriuretic Peptide, Brain, Blood Proteins, Protein Precursors, Genetic Markers, Risk Factors, Case-Control Studies, Prospective Studies, Computational Biology, Gene Frequency, Phenotype, Quantitative Trait Loci, Exons, Databases, Genetic, Norway, Venous Thromboembolism, Genetic Variation, Genome-Wide Association Study, biomarker, coronary artery disease, exome, human, protein, venous thromboembolism, Natriuretic Peptide, Brain, Databases, Genetic, Genetics, Medical Biotechnology, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

BackgroundGenetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated with diseases and physiological phenotypes.Methods and resultsAs part of a larger case-control study of venous thromboembolism, serum levels of 51 proteins implicated in cardiovascular diseases were measured in 330 individuals from the Tromsø Study. Exonic genetic variation near each protein's respective gene (cis) was identified using sequencing and arrays. Using single site and gene-based tests, we identified 27 genetic associations between pQTLs and the serum levels of 20 proteins: 14 associated with common variation in cis, of which 6 are novel (ie, not previously reported); 7 associations with rare variants in cis, of which 4 are novel; and 6 associations in trans. Of the 20 proteins, 15 were associated with single sites and 7 with rare variants. cis-pQTLs for kallikrein and F12 also show trans associations for proteins (uPAR, kininogen) known to be cleaved by kallikrein and with NTproBNP. We experimentally demonstrate that kallikrein can cleave proBNP (NTproBNP precursor) in vitro. Nine of the pQTLs have previously identified associations with 17 disease and physiological phenotypes.ConclusionsWe have identified cis and trans genetic variation associated with the serum levels of 20 proteins and utilized these pQTLs to study molecular mechanisms underlying disease and physiological phenotypes.

Published
2016

12. Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium

Author

Sinning, Christoph, Makarova, Nataliya, Völzke, Henry, Schnabel, Renate B., Ojeda, Francisco, Dörr, Marcus, Felix, Stephan B., Koenig, Wolfgang, Peters, Annette, Rathmann, Wolfgang, Schöttker, Ben, Brenner, Hermann, Veronesi, Giovanni, Cesana, Giancarlo, Brambilla, Paolo, Palosaari, Tarja, Kuulasmaa, Kari, Njølstad, Inger, Mathiesen, Ellisiv Bøgeberg, Wilsgaard, Tom, Blankenberg, Stefan, Söderberg, Stefan, Ferrario, Marco M., and Thorand, Barbara

Published
2021
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24. Association between neighborhood health behaviors and body mass index in Northern Norway: evidence from the Tromsø Study.

Author

Sari, Emre, Moilanen, Mikko, Bambra, Clare, Grimsgaard, Sameline, and Njølstad, Inger

Subjects
OBESITY, LEISURE, CONFIDENCE intervals, LIFE course approach, PHYSICAL activity, HEALTH behavior, DESCRIPTIVE statistics, DISEASE prevalence, RESEARCH funding, BODY mass index, RESIDENTIAL patterns, NEIGHBORHOOD characteristics, SECONDARY analysis
Abstract

Aim: The prevalence of overweight and obesity has risen rapidly worldwide, and the ongoing obesity pandemic is one of the most severe public health concerns in modern society. The average body mass index (BMI) of people living in Northern Norway has also steadily increased since the late 1970s. This study aimed to understand how individuals' health behavior is associated with the general health behavior of the people in their neighborhood. Methods: Using the population-based Tromsø Study, we examined the life course association between average leisure time physical activity at the neighborhood level and the BMI of individuals living in the same neighborhood. We used a longitudinal dataset following 25,604 individuals living in 33 neighborhoods and performed a linear mixed-effects analysis. Results: The results showed that participants living in neighborhoods whose residents were more physically active during their leisure time, were likely to have a significantly lower BMI (−0.9 kg/m², 95% CI −1.5 to −0.4). Also, individuals living in neighborhoods whose residents were doing mainly manual work, had significantly higher BMIs (0.7 kg/m², 95% CI 0.4−1.0). Conclusions: Our results showed a strong association between the average leisure time physical activity level of neighborhood residents and the higher BMI levels of residents of the same neighborhood. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses.

Author

Varmdal, Torunn, Løchen, Maja-Lisa, Wilsgaard, Tom, Njølstad, Inger, Nyrnes, Audhild, Grimsgaard, Sameline, and Mathiesen, Ellisiv B.

Subjects
STROKE diagnosis, REPORTING of diseases, DATA quality, PREDICTIVE tests, CONFIDENCE intervals, CARDIOVASCULAR diseases, DESCRIPTIVE statistics, SENSITIVITY & specificity (Statistics), DIAGNOSTIC errors, EPIDEMIOLOGICAL research
Abstract

Aim: To assess whether stroke diagnoses in national health registers are sufficiently correct and complete to replace manual collection of endpoint data for the Tromsø Study, a population-based epidemiological study. Method: Using the Tromsø Study Cardiovascular Disease Register for 2013–2014 as the gold standard, we calculated correctness (defined as positive predictive value, PPV) and completeness (defined as sensitivity) of stroke cases in four different data subsets derived from the Norwegian Patient Register and the Norwegian Stroke Register. We calculated the sensitivity and PPV with 95% confidence intervals (CIs) assuming a normal approximation of the binomial distribution. Results: In the Norwegian Stroke Register we found a sensitivity of 79.8% (95% CI 74.2–85.4) and a PPV of 97.5% (95% CI 95.1–99.9). In the Norwegian Patient Register the sensitivity was 86.4% (95% CI 81.6–91.1) and the PPV was 84.2% (95% CI 79.2–89.2). The overall highest levels were found in a subset based on a linkage between the Norwegian Stroke Register and the Norwegian Patient Register, with a sensitivity of 88.9% (95% CI 84.5–93.3), and a PPV of 89.3% (95% CI 85.0–93.6). Conclusions: Data from the Norwegian Patient Register and from the linked data set between the Norwegian Patient Register and the Norwegian Stroke Register had acceptable levels of correctness and completeness to be considered as endpoint sources for the Tromsø Study Cardiovascular Disease Register. The benefits of using data from national registers as endpoints in epidemiological studies must be weighed against the impact of potentially decreased data quality. [ABSTRACT FROM AUTHOR]

Published
2023
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29. sj-docx-1-sjp-10.1177_14034948221122395 – Supplemental material for Trends in prevalence, treatment and control of hypertension in 38,825 adults over 36 years in Tromsø prospective study

Author

Desai, Trishna, Clarke, Robert, Ross, Stephanie, Grimsgaard, Sameline, Njølstad, Inger, and Lewington, Sarah

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-1-sjp-10.1177_14034948221122395 for Trends in prevalence, treatment and control of hypertension in 38,825 adults over 36 years in Tromsø prospective study by Trishna Desai, Robert Clarke, Stephanie Ross, Sameline Grimsgaard, Inger Njølstad and Sarah Lewington in Scandinavian Journal of Public Health

Published
2023
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30. sj-docx-2-sjp-10.1177_14034948221122395 – Supplemental material for Trends in prevalence, treatment and control of hypertension in 38,825 adults over 36 years in Tromsø prospective study

Author

Desai, Trishna, Clarke, Robert, Ross, Stephanie, Grimsgaard, Sameline, Njølstad, Inger, and Lewington, Sarah

Subjects
111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences
Abstract

Supplemental material, sj-docx-2-sjp-10.1177_14034948221122395 for Trends in prevalence, treatment and control of hypertension in 38,825 adults over 36 years in Tromsø prospective study by Trishna Desai, Robert Clarke, Stephanie Ross, Sameline Grimsgaard, Inger Njølstad and Sarah Lewington in Scandinavian Journal of Public Health

Published
2023
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31. Sex-specific time trends in incident atrial fibrillation and the contribution of risk factors: the Tromsø Study 1994–2016

Author

Sharashova, Ekaterina, primary, Gerdts, Eva, additional, Ball, Jocasta, additional, Espnes, Hilde, additional, Jacobsen, Bjarne K, additional, Kildal, Simon, additional, Mathiesen, Ellisiv B, additional, Njølstad, Inger, additional, Rosengren, Annika, additional, Schirmer, Henrik, additional, Wilsgaard, Tom, additional, and Løchen, Maja-Lisa, additional

Published
2022
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32. Outcomes after coronary angiography for unstable angina compared to stable angina, myocardial infarction and an asymptomatic general population

Author

Fladseth, Kristina, primary, Wilsgaard, Tom, additional, Lindekleiv, Haakon, additional, Kristensen, Andreas, additional, Mannsverk, Jan, additional, Løchen, Maja-Lisa, additional, Njølstad, Inger, additional, Mathiesen, Ellisiv B, additional, Trovik, Thor, additional, Rotevatn, Svein, additional, Forsdahl, Signe, additional, and Schirmer, Henrik, additional

Published
2022
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33. Association of iron deficiency with incident cardiovascular diseases and mortality in the general population

Author

Schrage, Benedikt, Rübsamen, Nicole, Ojeda, Francisco M., Thorand, Barbara, Peters, Annette, Koenig, Wolfgang, Söderberg, Stefan, Söderberg, Maja, Mathiesen, Ellisiv B., Njølstad, Inger, Kee, Frank, Linneberg, Allan, Kuulasmaa, Kari, Tarja, Palosaari, Salomaa, Veikko, Blankenberg, Stefan, Zeller, Tanja, and Karakas, Mahir

Subjects
Male, Kardiologi, Cardiovascular, General Population, Iron Deficiency, Mortality, Risk Factor, Iron deficiency, Coronary Disease, General population, Original Articles, Iron Deficiencies, Middle Aged, SDG 3 - Good Health and Well-being, Cardiovascular Diseases, Risk Factors, Original Research Articles, RC666-701, Humans, Diseases of the circulatory (Cardiovascular) system, Original Article, Cardiac and Cardiovascular Systems, Original Research Article, Risk factor
Abstract

AIMS: Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population. METHODS AND RESULTS: In 12164 individuals from three European population-based cohorts, AID was defined as ferritin&nbsp

Published
2021

39. Vitamin D and mortality : meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States

Author

Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES), Schöttker, Ben, Jorde, Rolf, Peasey, Anne, Thorand, Barbara, Jansen, Eugène H J M, de Groot, Lisette, Streppel, Martinette, Gardiner, Julian, Ordóñez-Mena, José Manuèl, Perna, Laura, Wilsgaard, Tom, Rathmann, Wolfgang, Feskens, Edith, Kampman, Ellen, Siganos, Galatios, Njølstad, Inger, Mathiesen, Ellisiv Bøgeberg, Kubínová, Růžena, Pająk, Andrzej, Topor-Madry, Roman, Tamosiunas, Abdonas, Hughes, Maria, Kee, Frank, Bobak, Martin, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Published
2014

42. Abstract 17668: Heart Failure Epidemiology, Risk Factors and Mortality Risk by Gender in Community Cohorts Across Europe

Author

Magnussen, Christina, Niiranen, Teemu, Ojeda, Francisco M, Gianfagna, Francesco, Blankenberg, Stefan, Njølstad, Inger, Vartiainen, Erkki, Sans, Susana, Pasterkamp, Gerard, Costanzo, Simona, Donati, Maria Benedetta, Jousilahti, Pekka, Linneberg, Allan, Palosaari, Tarja, de Gaetano, Giovanni, Bobak, Martin, den Ruijter, Hester M, Mathiesen, Ellisiv, Jørgensen, Torben, Söderberg, Stefan, Kuulasmaa, Kari, Zeller, Tanja, Salomaa, Veikko, Iacoviello, Licia, and Schnabel, Renate B

Published
2017

43. Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)

Author

Magnussen, Christina, Niiranen, Teemu J., Ojeda, Francisco M., Gianfagna, Francesco, Blankenberg, Stefan, Njølstad, Inger, Vartiainen, Erkki, Sans, Susana, Pasterkamp, Gerard, Hughes, Maria, Costanzo, Simona, Donati, Maria Benedetta, Jousilahti, Pekka, Linneberg, Allan, Palosaari, Tarja, de Gaetano, Giovanni, Bobak, Martin, den Ruijter, Hester M., Mathiesen, Ellisiv, Jørgensen, Torben, Söderberg, Stefan, Kuulasmaa, Kari, Zeller, Tanja, Iacoviello, Licia, Salomaa, Veikko, and Schnabel, Renate B.

Published
2017
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44. Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis

Author

Paige, Ellie, Barrett, Jessica, Pennells, Lisa, Sweeting, Michael, Willeit, Peter, Di Angelantonio, Emanuele, Gudnason, Vilmundur, Nordestgaard, Børge G., Psaty, Bruce M, Goldbourt, Uri, Best, Lyle G, Assmann, Gerd, Salonen, Jukka T, Nietert, Paul J, Verschuren, W. M. Monique, Brunner, Eric J, Kronmal, Richard A, Salomaa, Veikko, Bakker, Stephan J L, Dagenais, Gilles R, Sato, Shinichi, Jansson, Jan-Håkan, Willeit, Johann, Onat, Altan, de la Cámara, Agustin Gómez, Roussel, Ronan, Völzke, Henry, Dankner, Rachel, Tipping, Robert W, Meade, Tom W, Donfrancesco, Chiara, Kuller, Lewis H, Peters, Annette, Gallacher, John, Kromhout, Daan, Iso, Hiroyasu, Knuiman, Matthew, Casiglia, Edoardo, Kavousi, Maryam, Palmieri, Luigi, Sundström, Johan, Davis, Barry R, Njølstad, Inger, Couper, David, Danesh, John, Thompson, Simon G, and Wood, Angela

Published
2017
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