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Artificial lighting is of considerable importance in livestock industry. If there is sufficient light flux and optimal spectral composition, it can have a substantial impact on the comfortable condition of cows, and, as a result, on milk producing ability. The sensitivity of the cow’s eye to optical radiation is varied in the range of the visible spectrum, and its visual apparatus is adapted to recognize natural different types of feed. The leaves of plants take up visible radiation in the red and blue regions of the spectrum, while they reflect intensely in the near-infra-red region. Consequently, cows, having the ability to perceive near-infrared radiation, can give favor to higher-quality feed, the consumption of which, among other things, will increase milk producing ability. The findings of the studies demonstrate that the cow’s eye reacts to near-infrared radiation, and the combined lighting contributes to a more adequate behavior of the animals, which in turn has a positive effect on milk producing ability.

The literature review evaluates the rehabilitation measures in the country's oncological institutions, assesses regulations in other countries, and scientific publications related to the rehabilitation of cancer patients. Studies were analysed using electronic databases PubMed, Medline, Science Direct, Scopus, Web of Science, e-Library, RSL. Over 47,900 sources were found, of which 50 papers over the past ten years were selected and included in the article. The criteria for inclusion were the rehabilitation of cancer patients, stages of rehabilitation, pre-rehabilitation, nutritional support, psychological assistance, and quality of patients’ life. Considering the urgency of the problem, WHO 2017 took the initiative and adopted the Rehabilitation 2030 program, which provides expanding global access to high-quality rehabilitation as an essential health service for people with non-communicable diseases. According to summarized data, rehabilitation is based on the following principles: stage-by-stage process, consistency, complexity, and individual approach. The stages of medical rehabilitation of cancer patients include pre-rehabilitation; stage I – a period of specialized treatment; stage II – rehabilitation in a hospital setting after discharge; and stage III – early and late rehabilitation periods. An analysis of the situation in Tajikistan showed that in oncology-related institutions, rehabilitation of cancer patients is carried out within the framework of existing protocols for individual nosology, where a set of measures for the stages of rehabilitation is not sufficiently developed. A practical assessment of the effectiveness of rehabilitation is not set up. The stereotype about limiting the use of physiotherapy and sanatorium-resort treatment for cancer patients persists. There are no regulations for comprehensive rehabilitation of cancer patients. The need to optimize treatment results, prolong the survival of patients with various functional disorders, and improve the quality of life dictates the necessity for the development and systematic implementation of comprehensive rehabilitation of cancer patients.

Background: Multi Drugs Resistance (MDR) is among the most worrisome healthcare issues resulting from inappropriate and indiscriminate utilization of antimicrobial agents which has compromised the efficacy and reliability of antimicrobial agents (AMAs). This has not only put a huge burden on the health care system but also is a major cause of morbidity and mortality. This project was designed to evaluate the prevalence of various microbial strains among patients admitted to various teaching hospitals and to assess their susceptibility and resistance towards clinically approved antibiotics. Methods: The study was conducted during August 2021-February 2022 to determine the prevalence of common resistant strains of bacteria and to analyze their susceptibility pattern to the commonly prescribed antibiotics using standard procedures. One hundred and thirty biological samples including urine, blood, cerebrospinal fluid (CSF), wound swabs, pus and sputum were collected from the site of infection from the patients admitted at different wards of North West General Hospital (NWGH), Peshawar, Pakistan, Khyber Teaching Hospital (KTH), Peshawar Pakistan, and Hayat Abad Medical Complex (HMC) Peshawar Pakistan. Samples were collected and cultured following standard hospital procedures. The cultured samples were subjected to identification procedures including Gram staining, morphological characterization of bacterial colonies and biochemical assessments. The identified bacteria were tested for their susceptibility using Kirby-Bauer disc diffusion method. The diameter of Inhibitory Zones (DIZ) was analyzed following Clinical and Laboratory Standards Institute (CLSI) criteria. Minimum Inhibitory Concentrations (MICs) were evaluated using agar dilution method. Antimicrobials sensitivity were presented as antibiogram following CLSI M39 standard. Results: A total of one hundred and thirty biological samples were collected, out of which one hundred and nine samples were positive for bacterial growth and were further processed for detailed analysis. The frequency and type of bacteria isolated from various cultures indicated that Gram negative bacteria (n = 92/109) were more dominant than Gram-positive (n = 17/109) pathogens. The most prevalent bacteria isolated was Escherichia coli (29.35 %), followed by Staphylococcus aureus (15.59 %), and Klebsiella spp, (12.84 %). In addition, other pathogens including, Enterobacter spp, Citrobacter spp, and Acinetobacter spp. showed a prevalence of 9.175 %, 8.25 %, and 5.50 % respectively. As indicated in the antbiogram, several organisms exhibited considerble decline in the sensitivies towards various antibiotics. A high percentage of resistance was observed against some antibiotics including trimethoprim, co-trimoxazole, amoxicillin/clavulanate, ciprofloxacin, piperacillin/tazobactam, cefotaxime and ceftazidime. Conclusion: The prevalence of resistant strains of pathogens is increasing day by day, while the antibiotics commonly prescribed against them are losing their efficacy, which is pushing the world to the era of pre-antibiotics. Unfortunately, the discovery of novel antibiotics is limited and researchers speculate that the is pushing towards pre-antibiotics era. Subsequently, efforts must be directed towards ensuring rational antibiotics use to prevent emergence of MDR pathogens. Our findings indicated that Gram negative bacteria including Escherichia coli was most prevalent. Other bacterial strains including S. aureus, Klebsiella spp, Enterobacter spp, Citrobacter spp, and Acinetobacter spp. were found among the causative agents. Unfortunately, considerable decline in the sensitivities of various bacterial isolated were observed towards the tested antibiotics. Previous studies reported the high prevalence of E. coli and S. aureus in clinical samples of Pakistani hospitals including hospitals in Peshawar and thus our findings are in agreement with the previous reports. Pharmacists being experts can play their role by promoting the optimal use of antimicrobial agents and educating healthcare professionals, patients and the public.

AimTo examine clinical characteristics, real-world treatment patterns, and health outcomes among patients with germline BRCA1/2-mutated, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer (ABC).MethodsA retrospective analysis was conducted using medical records from patients with HER2-negative ABC with BRCA1/2 mutation who received cytotoxic chemotherapy. Data were stratified into groups with triple-negative breast cancer (TNBC) or hormone receptor–positive (HR+)/HER2-negative diagnoses. Time-to-event outcomes (i.e., real-world progression-free survival [rwPFS] and overall survival [OS]) were calculated to summarize health outcomes.ResultsWhen diagnosed with ABC, most patients were younger than 60 years (mean age = 57.3 years), were white (76.4%), and had a family history of BRCA-related cancer (71.5%). A total of 305 patient records were examined; 194 patients (63.6%) had advanced TNBC, and 111 patients (36.4%) had HR+/HER2-negative ABC. Chemotherapy was primarily used as first-line treatment for both subgroups, but the TNBC subgroup received poly (ADP-ribose) polymerase (PARP) inhibitors at triple the rate as a second-line treatment and double the rate as a third-line treatment compared with the HR+/HER2-negative subgroup. Two-year OS rates were similar between the TNBC (73.9%) and the HR+/HER2-negative subgroups (77.0%), and anemia, nausea, and neutropenia were the most commonly reported toxicities across all treatments.ConclusionClinicians should consider the use of targeted agents such as PARP inhibitors in earlier lines of therapy for ABC given the growing evidence that PARP inhibitors may improve PFS compared with chemotherapy while potentially offering a more manageable toxicity profile and improved quality of life.

The article examines the issues of creating a power flexible cable production in the country (Republic of Kazakhstan). The research objective of the study is to assess the technical and economic feasibility for organization of such production. Production program, investment estimation (cost sheet) and model of financial and economic payback for this project were calculated in course of the article’s research. The research confirms the effectiveness of the creation for cable production in Kazakhstan, also this project can be recommended for implementation.

Abstract. Aortic dissection is a rupture of the inner layer of the aorta with subsequent penetration of blood into the degeneratively altered middle layer with the formation of false lumen and true lumen. Pregnancy is one of the risk factors for the development of aortic dissection. The incidence of aortic dissection during pregnancy is only 0.0004% of cases.Aim of the study. To analyze national and foreign literature, as well as share own clinical observations in the diagnosis and treatment of patients with aortic dissection in the postpartum period.Material and methods. Two patients after successful childbirth, in the late postpartum period, were admitted with a diagnosis of aortic dissection type A according to Stanford.CT angiography confirmed the presence of Stanford type A aortic dissection. After additional examination, surgical treatment was performed to replace the aortic valve and ascending aorta under artificial circulation, with a satisfactory clinical result.Conclusion. The diagnosis of aortic dissection should be considered in all pregnant women with chest pain, as this condition often goes undiagnosed.The pregnancy period is one of the risk factors for the development of aortic dissection with a high mortality rate. The likelihood of developing aortic dissection in women at risk peaks in the third trimester and the first 12 weeks after delivery.The risk group should include women with confirmed syndromic and non-syndromic genetic diseases, bicuspid aortic valve, coarctation of the aorta, or at least one major criterion indicating the presence of aortopathy (ectopia lentis, aortic aneurysm, habitus, genetic testing).If Marfan syndrome is present, surgical intervention should be considered if the maximum aortic diameter is more than 4.5 cm before pregnancy. In women with Marfan syndrome and aortic dissection in the family history, as well as in the presence of more aggressive genetic diseases (Loeys-Dietz syndrome, Ehlers-Danlos syndrome), it is possible to consider preventive surgical treatment for an aortic diameter of 4.0 cm or more.The delivery in high-risk patients is recommended to be performed in a hospital that has a cardiac surgery service and an “aortic” team.

Background. Programs to improve the quality of higher education in recent decades have kept the lead in the relevance among researchers around the world. In this scientific work, the purpose was to highlight modern existing programs in the postgraduate education of doctors in the Republic, review the academic competencies from other countries of the world, develop recommendations for improving the organizational structure of educational methods, as well as to increase significantly the effectiveness of the additional educational process. Materials and methods. When writing the work, methods such as analysis, synthesis, review of literary sources, humanitarian and dialectical were used. Results. The results of the research were as follows: the application of competence-oriented adaptation programs in the training of graduates, the reorientation of the system of additional medical education in Kyrgyzstan, as well as the development and implementation of a learning model based on pedagogical prognosis, communication logistics, engineering technologies and the humanitarian and creative approach among all participants in the educational process. Conclusions. The result of the article included the development of recommendations for the correct and modern adaptation of a doctor to changing conditions and requirements of the labour market in the Kyrgyz Republic given the volatility of this market and its sensitivity to changes in the economy and the psychological attitudes of the society.

Real-world data and real-world evidence play an increasingly important role in clinical research and healthcare decisionmaking. To use data and generate robust evidence effectively, they must be clearly defined and structured, semantically compatible and harmonized among stakeholders. On June 30, 2023, the International Council on Harmonization (ICH) presented for discussion a reflection paper on “International Harmonisation of Real-World Evidence Terminology and Convergence of General Principles Regarding Planning and Reporting of Studies Using Real-World Data, with a Focus on Effectiveness of Medicines”, which outlines their approach to achieve international integration in this area. This article provides an overview of the key aspects of the strategic plan proposed by the ICH.

The ERASMUS+ initiative funded, in 2019, a Capacity Building project named ERAMCA (Environmental Risk Assessment and Mitigation in Central Asia) to build up a study plan at the Master of Science level (120 ECTS in 2 academic years) open to Architects, Civil, Building, and Environmental Engineers to build-up a new generation of professionals able to work in a team with different specialities to document Cultural Heritage assets by considering environmental risks. These new professionals will be able to set up the helpful basic knowledge to plan future actions of preservation and enhancement by following the most recent development in the restoration field at the international level.The ERAMCA project started with a survey of the basic knowledge of architects and engineers in Uzbekistan and Tajikistan on the documentation of natural and anthropic risks.By considering the common knowledge, the Partners of the ERAMCA project (3 European Universities from Italy, Germany, and Croatia and 4 Universities from Uzbekistan and Tajikistan) realised a study plan by concentrating the teaching activity on the following disciplines: Geomatics, Restoration, Structure and Seismic Engineering, Hydrogeology and Geotechnics.ERAMCA project is in its last year of activity, and the final results can be presented and discussed among the Cultural Heritage Documentation community to offer possible suggestions for future actions to diffuse documentation strategies.

The research was carried out as part of the preparation “Water Resources” section of the 4th National Communication of the Kyrgyz Republic to the UNFCCC. The article presents extensive information on the current state and changes over a long period of observations of water resources, climate and glaciation in Kyrgyzstan (Syr-Darya and Amu-Darya river basins). The representative rivers were selected as the main objects, which are transboundary between Kyrgyzstan, Uzbekistan, Kazakhstan and Tajikistan. The study aims to assess the inter-annual and intra-annual dynamics of the flow of the rivers for the period from 2020 to 2080, based on the climate projections CMIP5 (RCP4.5 and RCP8.5) and CMIP6 (SSP2-4.5 and SSP5-8.5) (IPCC WG II Report, 2022). The hydrological modeling method in the HBV light and HBV EHT models and the inertial mean annual flow change method were used to estimate changes in water resources. On the rivers of the northern part of the Fergana Valley, the average annual runoff is expected to increase by 1-19%, in the Amudarya river basin (Kyzyl-Suu river) – by 27-64% of the values for 2006-2019. In the Naryn river, water discharge for this period will remain within the current values for 2006-2019. The method of inertial change in the average annual runoff showed an increase in runoff for 2030 and 2040 for all the studied catchment areas by 6-19% of the current values for 2006-2020. The results of the study are intended for decision-makers on the rational use and long-term planning of water resources under climate change.

Clinical case. A patient after mitral valve replacement surgery for infective endocarditis was hospitalized with a new coronavirus infection. The examination revealed a left ventricular-right atrial communication. The complex treatment with a good clinical effect was performed at the N.V. Sklifosovsky Research Institute for Emergency Medicine. Conclusions In the context of a pandemic of a new coronavirus infection, patients with a new coronavirus infection who have undergone a history of heart surgery are subject to greater clinical vigilance regarding the development of postoperative complications, including rare ones.

INTRODUCTION Transposition of the great arteries is the second most common cyanotic congenital heart defect after tetralogy of Fallot. The arterial switch procedure (А. Jatene, 1975) is the surgical treatment of choice. Neoaortic root dilatation and valve regurgitation are quite common among the patients who underwent surgery for transposition of the great arteries. However, there are a lot of conflicting data about their direct connection.CLINICAL CASE This article describes surgical repair of neoaortic bicuspid valve regurgitation, by it successful implantation, in an 18-year-old patient after arterial switch operation for transposition of the great arteries in the neonatal period.CONCLUSION Neoaortic valve insufficiency can develop primarily as well as secondary to neoaortic root dilatation, however, the questions about valve repair or aortic root replacement with or without neoaortic valve implantation remains debatable. At this stage, decision making is based only on unsystematic clinical experience, surgeon’s intuition, the basics of anatomy and pathophysiology, as well as close interaction of “pediatric” and “adult” cardiac surgeons.

Light propagation through magnetic media with ellipsoidal inclusions much smaller than the light wavelength was investigated theoretically. It is assumed that the ellipsoidal inclusions have the same orientation but are randomly distributed inside the magnetic medium by the Gaussian law. The theoretical model is based on the multiple-scattering theory in the ladder approximation. A new type of electromagnetic field correlation is found to appear in this case, while it is absent in isotropic magnetic nanocomposites and nonmagnetic anisotropic composites. This feature allows for the precise control of light polarization in anisotropic magnetic media.

In the article, the prevalence of cows with mycotic etiology purulent-catarrhal endometritis, clinical symptoms and types of fungi and their sensitivity to drugs were studied in the conditions of farms specializing in cattle breeding of the districts of Samarkand region. It was analyzed that in endometritis of bacterial-mycotic etiology, the body temperature and heart rate, high breathing, and their sharp increase with the increase of the inflammatory process in the uterus, as well as the presence of traces of white loose films on the lower surface of the vaginal mucosa, are the main clinical signs. When examining samples taken from the uterus of cows infected with purulent-catarrhal endometritis of bacterial and mycotic etiology, Candida albicans 41.8-45.2%, Candida glabrata 26.8-29.2%, and Candida krusei 26.0-30.0% and it was studied that the highest indicator of the zones formed in terms of antibiotic sensitivity of microbes was observed in discs soaked with fluconazole and ketoconazole, and the lowest indicator appeared in discs soaked with nystatin and emulsion.

In the original version of this article, authors Jill L. Silverman and Stephen W. Scherer were listed with incorrect affiliations; this has now been corrected.

The underpinnings of mild to moderate neurodevelopmental delay remain elusive, often leading to late diagnosis and interventions. Here, we present data on exome and genome sequencing as well as array analysis of 13 individuals that point to pathogenic, heterozygous, mostly de novo variants in WDFY3 (significant de novo enrichment P = 0.003) as a monogenic cause of mild and non-specific neurodevelopmental delay. Nine variants were protein-truncating and four missense. Overlapping symptoms included neurodevelopmental delay, intellectual disability, macrocephaly, and psychiatric disorders (autism spectrum disorders/attention deficit hyperactivity disorder). One proband presented with an opposing phenotype of microcephaly and the only missense-variant located in the PH-domain of WDFY3. Findings of this case are supported by previously published data, demonstrating that pathogenic PH-domain variants can lead to microcephaly via canonical Wnt-pathway upregulation. In a separate study, we reported that the autophagy scaffolding protein WDFY3 is required for cerebral cortical size regulation in mice, by controlling proper division of neural progenitors. Here, we show that proliferating cortical neural progenitors of human embryonic brains highly express WDFY3, further supporting a role for this molecule in the regulation of prenatal neurogenesis. We present data on Wnt-pathway dysregulation in Wdfy3-haploinsufficient mice, which display macrocephaly and deficits in motor coordination and associative learning, recapitulating the human phenotype. Consequently, we propose that in humans WDFY3 loss-of-function variants lead to macrocephaly via downregulation of the Wnt pathway. In summary, we present WDFY3 as a novel gene linked to mild to moderate neurodevelopmental delay and intellectual disability and conclude that variants putatively causing haploinsufficiency lead to macrocephaly, while an opposing pathomechanism due to variants in the PH-domain of WDFY3 leads to microcephaly.

This article describes the use and advantages of the MATLAB-based program ReshmoBeam, developed to perform beam analysis, as it is done in statics courses of engineering curricula. An important goal of the article is to facilitate the dissemination of the program among faculty teaching these courses. The program is offered free to interested faculty for potential application in their courses. The program is not intended to compete with existing software for this purpose. Existing programs can be comprehensive; however, the user must pay to use all or some of their features. ReshmoBeam covers a limited, but important range of situations in beam analysis. The program determines the reactions at the beam supports, the shear and bending moment values at points specified by the user if desired, and the maximum values of shear and bending moment. The program also generates the loading, shear, and bending moment diagrams for the beam situation under analysis. Students can quickly verify the correctness of their manual calculations and also explore a diverse range of loading conditions. Furthermore, its use could facilitate a deeper understanding of the material taught in the course.

What is this summary about? This summary is about the ongoing research study called TALAPRO-3. This study is testing the use of two medicines called talazoparib and enzalutamide. The two medicines are being used together as a treatment for patients with a type of cancer called metastatic castration-sensitive prostate cancer and changes in specific DNA repair genes within their tumors. The study began in May 2021, and includes 599 patients from 27 countries. What is metastatic castration-sensitive prostate cancer? Metastatic castration-sensitive prostate cancer is known as mCSPC for short. It is cancer that has started in the prostate and spread to other body parts. The prostate is a gland below the bladder and helps make semen (the liquid that contains sperm). Castration-sensitive means that the cancer responds to treatments that lower testosterone in the blood. Which medicines are being tested? In this study, some patients will take talazoparib plus enzalutamide while others will take a placebo plus enzalutamide. Talazoparib and enzalutamide are two different cancer medicines. Talazoparib is not currently used to treat patients with mCSPC. Enzalutamide is used to treat patients with prostate cancer. Talazoparib plus enzalutamide is being compared with a placebo plus enzalutamide to see if patients live longer without their cancer getting worse, or them dying, when taking talazoparib plus enzalutamide or when taking a placebo plus enzalutamide. What are the aims of the TALAPRO-3 study? This study aims to find out if treatment with talazoparib plus enzalutamide increases the length of time the patients in the study live without their cancer getting worse, or them dying, compared with treatment with a placebo plus enzalutamide. The study will also measure how long the patients in the study live, the number and types of side effects they have, their general health and quality of life, and whether there are changes in how patients report their pain. Clinical Trial Registration:NCT03395197 (TALAPRO-2) (ClinicalTrials.gov) [ABSTRACT FROM AUTHOR]