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172 results on '"Niwa, Akihiro"'

9. Impact of strict fluid management on the treatment outcome of clazosentan for cerebral vasospasm

Author

Itazu, Takaaki, primary, Ikedo, Taichi, additional, Tsutsui, Takeyoshi, additional, Niwa, Akihiro, additional, Kushi, Yuji, additional, Ozaki, Saya, additional, Yamada, Naoto, additional, Shimonaga, Koji, additional, Hamano, Eika, additional, Yamada, Kiyofumi, additional, Imamura, Hirotoshi, additional, Mori, Hisae, additional, Iihara, Koji, additional, and Kataoka, Hiroharu, additional

Published
2023
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23. Inside Back Cover Picture: Plasma Process. Polym. 10/2020

Author

Nakamura, Kae, primary, Yoshikawa, Nobuhisa, additional, Yoshihara, Masato, additional, Ikeda, Yoshiki, additional, Higashida, Akihiro, additional, Niwa, Akihiro, additional, Jindo, Takahiro, additional, Tanaka, Hiromasa, additional, Ishikawa, Kenji, additional, Mizuno, Masaaki, additional, Toyokuni, Shinya, additional, Hori, Masaru, additional, Kikkawa, Fumitaka, additional, and Kajiyama, Hiroaki, additional

Published
2020
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25. Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma‐activated solutions

Author

Nakamura, Kae, primary, Yoshikawa, Nobuhisa, additional, Yoshihara, Masato, additional, Ikeda, Yoshiki, additional, Higashida, Akihiro, additional, Niwa, Akihiro, additional, Jindo, Takahiro, additional, Tanaka, Hiromasa, additional, Ishikawa, Kenji, additional, Mizuno, Masaaki, additional, Toyokuni, Shinya, additional, Hori, Masaru, additional, Kikkawa, Fumitaka, additional, and Kajiyama, Hiroaki, additional

Published
2020
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27. Long-term Treatment with Toceranib Phosphate in a Dog with Metastatic Primary Pulmonary Adenocarcinoma

Author

Tamura Yu, Endo Yoshifumi, Kadosawa Tsuyoshi, Niwa Akihiro, and Matsuda Kazuya

Subjects
0301 basic medicine, medicine.medical_specialty, Long term treatment, Toceranib Phosphate, 040301 veterinary sciences, business.industry, Pulmonary adenocarcinoma, 04 agricultural and veterinary sciences, Gastroenterology, 0403 veterinary science, 03 medical and health sciences, 030104 developmental biology, Internal medicine, Medicine, business, Biomedical engineering
Published
2017

34. Left ventricular filling abnormalities in non-insulin-dependent diabetes mellitus and improvement by a short-term glycemic control

Author

Hiramatsu, Kunihide, Ohara, Noriko, Shigematsu, Satoshi, Aizawa, Toru, Ishihara, Fujiki, Niwa, Akihiro, Yamada, Takashi, Naka, Motoji, Momose, Atsushi, and Yoshizawa, Kunio

Subjects
Heart ventricle, Left -- Abnormalities, Type 2 diabetes -- Complications, Blood sugar monitoring -- Physiological aspects, Health
Abstract

To determine whether left ventricular (LV) tilling abnormalities in diabetes are associated with diabetic microangiopathy, and to evaluate the effect of a short-term glycemic control on the tilling abnormalities, diastolic tilling dynamics were assessed by pulsed Doppler echocardiography in 246 patients with non-insulin-dependent diabetics. Isovolumic relaxation time and the ratio of peak flow velocity of atrial tilling wave to peak flow velocity of early tilling wave (A/E) were signiticantly greater in diabetic patients than in ageand sex-matched control subjects. Diabetic patients with retinopathy hod significantly greater isovolumic relaxation time and A/E values than those without retinopathy. A/E was significantly decreased 1 tenth after insulin treatment in those without, but not with retinopathy. It is concluded thor LV diastolic filling is impaired in mildly hyperglycemic patients with non-insulin-dependent diabetes mellitus without severe complications, the abnormality being more intense in patients with retinopathy. A short-term glycemic control results in a marked decrease in abnormalities in patients without, but not with retinopathy. (Am J Cardiol 1992;70:1185-1189)

Published
1992

35. Brainstem pilocytic astrocytoma with H3 K27M mutation: case report

Author

Morita, Shuhei, primary, Nitta, Masayuki, additional, Muragaki, Yoshihiro, additional, Komori, Takashi, additional, Masui, Kenta, additional, Maruyama, Takashi, additional, Ichimura, Koichi, additional, Nakano, Yoshiko, additional, Sawada, Tatsuo, additional, Koriyama, Shunichi, additional, Tsuzuki, Shunsuke, additional, Yasuda, Takayuki, additional, Hashimoto, Kazutoshi, additional, Niwa, Akihiro, additional, and Kawamata, Takakazu, additional

Published
2018
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41. Carbon beam therapy in recurrent ovarian cancer

Author

Niwa, Akihiro, Suzuki, Kyosuke, Kato, Shingo, Kajiyama, Hiraki, Shibata, Kiyosumi, Ino, Kazuhiko, Nakamura, Hisao, Kikkawa, Fumitaka, and et.al

Abstract

Ovarian cancer results in more deaths than any other gynecologic malignancy. In the United States and Japan, there are over 15,000 and 4,000 deaths from ovarian cancer per year, respectively [1]. This high mortality rate can be attributed to the approximately 75% of patients who are diagnosed with stage III and IV disease with intraperitoneal carcinomatosis [2]. Although the five-year survival rate of patients in whom lymph nodes are the only site of metastasis, the so-called "retroperitoneal stage IIIc", ranges from 84 to 96%, higher than the 20-30% of intraperitoneal stage IIIc patients [3], we have sometimes encountered cases of ovarian cancer with local recurrence in the lymph nodes which was completely unresectable at surgery and chemoresistant, resulting in salvage chemotherapy. Therefore, a more potent treatment should be introduced for this situation to achieve either disease-free survival or local control. High linear energy transfer (LET) particle therapy has various advantages in terms of radiobiological effects as well as dose distribution and has been expected to offer a therapeutic advantage over conventional photon therapy. The biological advantages of high LET radiation, including carbon beam therapy, are summarized as a decreased oxygen enhancement ratio, diminished capacity for sublethal and potentially lethal damage repair, and diminished cell cycle-dependent radiosensitivity [4]. Thus, these advantages prompted us to use carbon beam therapy for bulky recurrent ovarian tumor, which is considered to have a large fraction of hypoxic tumor. The patient was a 68-year-old woman with ovarian cancer who was optimally treated by hysterectomy, bilateral salpingo-oophorectomy, omentectomy and pelvic and para-aortic lymphadenectomy in Feb.2003, followed by three courses of paclitaxel and carboplatin (TJ) for right ovarian cancer, endometrioid type, grade 2, pT1cN0M0. Since local recurrence of ovarian cancer at the site of the right internal-iliac artery lymph node was detected in Nov.2004, six more courses of TJ were performed. The recurrent tumor had grown to a maximum 8 cm in diameter despite several protocols of chemotherapy, including platinium, taxane, CPT-11 and gemcitabine. After we had confirmed no metastasis besides the recurrence site with positron emission tomography using fluorine-18 fluorodeoxyglucose /CT (FDG-PET/CT), we decided to treat the lesion with carbon beam therapy. Before the therapy, the patient gave written informed consent, and the study was approved by the local ethics committee and institutional review board of our hospital. Moreover, the patient underwent an operation in which a Goretex sheet was inserted, the lesion was partially excised and an artificial anus was constructed to protect the intestine and rectum adjacent to the tumor from injury by high LET particles. The heavy-ion medical accelerator in Chiba is the first heavy ion accelerator specially dedicated to medicine in the world, and its design variables are based on the radiological requirements [5]. The carbon beam energy used was 350 to 400 MeV. As shown in Figs. A and B, anteroposterior, posteroanterior and lateral opposing ports were used for 16 fractions over 4 weeks with 4 fractions weekly, consequently, the total dose was a 57.6 Gy equivalent dose. Through out the treatment, no severe side effects were observed. At ten months after treatment, the pelvic tumor had drastically shrunk (Fig.C), and the patient has continued clinical disease free for 2 years. This is the first report, to our knowledge, showing that carbon beam therapy was effective for recurrent ovarian cancer. The result is sufficiently encouraging to continue the therapy in patients with metastatic, anti-cancer-drug-resistant ovarian cancer, as well as other types of gynecologic cancer.

Published
2008

45. TCT-517 Effects Of Intravenous Human Atrial Natriuretic Peptide On Left Ventricular Function In Patients With Reperfused Acute Myocardial Infarction: An Assessment By Cardiac Magnetic Resonance Imaging

Author

Onishi, Takayuki, primary, Onishi, Yuko, additional, Umezawa, Shigeo, additional, Kobayashi, Isshi, additional, Otani, Hirofumi, additional, Tachibana, Keiko, additional, Kujiraoka, Ken, additional, Muramoto, Hirotaka, additional, Nagata, Yasutoshi, additional, and Niwa, Akihiro, additional

Published
2012
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47. Impact of right ventricular dysfunction assessed by cardiac magnetic resonance imaging on prediction of short term and long term prognoses after acute inferior myocardial infarction

Author

Onishi, Takayuki, primary, Kawashima, Tomoyuki, additional, Muramoto, Hirotaka, additional, Nakamura, Hiroaki, additional, Nagata, Yasutoshi, additional, Kobayashi, Isshi, additional, Onishi, Yuko, additional, Umezawa, Shigeo, additional, and Niwa, Akihiro, additional

Published
2011
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48. Safety and Stability of Right Ventricular Septal Pacing Compared with Right Ventricular Apex Pacing in Our Hospital

Author

Nakamura, Hiroaki, primary, Kobayashi, Isshi, additional, Otani, Hirofumi, additional, Tachibana, Keiko, additional, Kujiraoka, Ken, additional, Muramoto, Hirotaka, additional, Onishi, Takayuki, additional, Nagata, Yasutoshi, additional, Onishi, Yuko, additional, Umezawa, Shigeo, additional, Niwa, Akihiro, additional, and Isobe, Mitsuaki, additional

Published
2011
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