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268 results on '"Niu, Zhongwei"'

42. Combating Pseudomonas aeruginosaBiofilms by a Chitosan-PEG-Peptide Conjugate via Changes in Assembled Structure

Author

Ju, Xiaoyan, Chen, Jun, Zhou, Mengxue, Zhu, Meng, Li, Zhuang, Gao, Sijia, Ou, Jinzhao, Xu, Dandan, Wu, Man, Jiang, Shidong, Hu, Yi, Tian, Ye, and Niu, Zhongwei

Abstract

Pseudomonas aeruginosa(P. aeruginosa) biofilms are associated with a wide range of infections, from chronic tissue diseases to implanted medical devices. In a biofilm, the extracellular polymeric substance (EPS) causes an inhibited penetration of antibacterial agents, leading to a 100–1000 times tolerance of the bacteria. In view of the water-filled channels in biofilms and the highly negative charge of EPS, we design a chitosan-polyethylene glycol-peptide conjugate (CS-PEG-LK13) in this study. The CS-PEG-LK13prefers a neutrally charged assembly at a size of ∼100 nm in aqueous environment, while undergoes disassembly to expose the α-helical peptide at the bacterial cell membrane. This behavior provides CS-PEG-LK13superiorities in both penetrating the biofilms and inactivating the bacteria. At a concentration of 8 times the minimum inhibitory concentration, CS-PEG-LK13has a much higher antibacterial efficiency (72.70%) than LK13peptide (15.24%) and tobramycin (33.57%) in an in vitro P. aeruginosabiofilm. Moreover, CS-PEG-LK13behaves comparable capability of combating an implanted P. aeruginosabiofilm to highly excess tobramycin. This work has implications for the design of new antibacterial agents in biofilm combating.

Published
2020
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43. Programming Self-Assembly of Tobacco Mosaic Virus Coat Proteins at Pickering Emulsion Interfaces for Nanorod-Constructed Capsules

Author

Wang, Zhaocheng, Gao, Sijia, Liu, Xiangxiang, Tian, Ye, Wu, Man, and Niu, Zhongwei

Abstract

Pickering emulsion constructions on nanorods with high aspect ratio are a great challenge because of the geometry restrictions. On the basis of the theory that the stability of Pickering emulsion is highly dependent on the size and amphiphilicity of the nanoparticle at fluid interfaces, we report a novel strategy to fabricate long-time stable Pickering emulsion consisting of tobacco mosaic virus (TMV)-like nanorods through the programming self-assembly of TMV coat protein (TMVCP). The first step is the self-assembly of amphiphilic TMVCP at Pickering emulsion interfaces, and the second step is the in situ interfacial self-assembly of TMVCP into nanorods with increased particle size. The robust capsules can be further fabricated through cross-linking of the proteins. By taking advantage of both the amphiphilicity of TMVCP and the subsequent size growth induced by TMVCP self-assembly, this work provides a powerful strategy for constructing robust capsules consisting of nanorods with high aspect ratio, which may show potential applications for drug delivery and virus recognition.

Published
2024
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