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Solid-state batteries based on a metallic Li anode and nonflammable solid electrolytes (SEs) are anticipated to achieve high energy and power densities with absolute safety. In particular, cubic garnet-type Nb-doped Li 7 La 3 Zr 2 O 12 (Nb-LLZO) SEs possess superior ionic conductivity, are feasible to prepare under ambient conditions, have strong thermal stability, and are of low cost. However, the interfacial compatibility with Li metal and Li dendrite hazards still hinder the applications of Nb-LLZO. Herein, a quick and efficient solution was applied to address this issue, generating a nano-Li 3 PO 4 pre-reduction layer from the reaction of H 3 PO 4 with the ion-exchanged passivation layer (Li 2 CO 3 /LiOH) on the surface of Nb-LLZO. A lithiophilic, electrically insulating interlayer is in situ created when the Li 3 PO 4 modified layer interacts with molten Li, successfully preventing the reduction of Nb 5+ . The interlayer, which mostly consists of Li 3 P and Li 3 PO 4 , also has a high shear modulus and relatively high Li + conductivity, which effectively inhibit the growth of Li dendrites. The Li|Li 3 PO 4 |Nb-LLZO|Li 3 PO 4 |Li symmetric cells stably cycled for over 5000 h at 0.05 mA cm -2 and over 1000 h at a high rate of 0.15 mA cm -2 without any short circuits. The LiFePO 4 and S/C hybrid solid-state batteries using the modified Nb-LLZO electrolyte also demonstrated good electrochemical performances, confirming the practical application of this interfacial engineering in various solid-state battery systems. This work offers an efficient solution to the instability issue between the Nb-LLZO SE and metallic Li anode.

Lipid deposition induced various diseases including nonalcoholic fatty liver and hyperlipemia. The excessive accumulation of triglyceride (TG) and the deposition of fat were the two most critical causes. Here, we developed Fe 3 O 4 @OA@Poloxamer nanoparticles (NPs) with amphiphilic structures, which exhibited an excellent role in eliminating excess TG. Hydrophobic TG was adsorbed efficiently by Fe 3 O 4 @OA@Poloxamer NPs through the "liposuction effect" and the formation of NPs@TG complex was then conducted. The NPs@TG complex was further enclosed by the endosome based on the endocytosis and subsequently was taken into the lysosome, degrading with the help of lipases. Meanwhile, the "nano-enzyme effect" of Fe 3 O 4 NPs recovered the lipid-regulated proteins including PPARα, further triggering biodegradation pathways of TG, although the lipid-regulated proteins were obviously inhibited in the high-fat hepatocytes models. These two mechanisms of Fe 3 O 4 @OA@Poloxamer NPs together achieved the down-regulation of TG in vivo and in vitro. Therefore, our findings provided a novel thought in treating these diseases associated with lipid deposition, that is, nanoparticles modified by specific structure exhibit a superior TG removal., (Copyright © 2019 Elsevier B.V. All rights reserved.)