Search

Your search keyword '"Niu, Xuyan"' showing total 27 results
Start Over Author "Niu, Xuyan"
27 results on '"Niu, Xuyan"'

1. Activation of protein kinase A signaling and inhibitions of glycine/glutathione biosynthesis involves in the transition from prediabetes to diabetes based on metabolomics data analysis

Author

Zhao, Ning, primary, Gu, Zhan, additional, Li, Li, additional, Jiang, Miao, additional, Chen, Weini, additional, Liu, Biao, additional, Zhu, Junxuan, additional, Guo, Yuming, additional, He, Xiaojuan, additional, Zhang, Chi, additional, Niu, Xuyan, additional, Zhan, Junping, additional, Cheng, Shiping, additional, Kong, Hongwei, additional, Lu, Cheng, additional, and Lu, Aiping, additional

Published
2020
Full Text
View/download PDF

3. Mechanism of herbal pairs with the properties of Qi-tonifying, blood activation, blood-stasis breaking in treating coronary heart disease

Author

Zhao Ning, Niu Xuyan, Lei Yan, Li Li, Lü Aiping, He Xiaojuan, Li Jian, Jiang Miao, and Yang Jing

Subjects
0301 basic medicine, Qi, medicine.medical_treatment, Estrogen receptor, Coronary Disease, Traditional Chinese medicine, Blood stasis, Pharmacology, Retinoid X receptor, complex mixtures, 03 medical and health sciences, Humans, Medicine, Medicine, Chinese Traditional, Pregnane X receptor, Traditional medicine, business.industry, Mechanism (biology), food and beverages, General Medicine, Coronary heart disease, 030104 developmental biology, Cytokine, Blood Circulation, Drug Therapy, Combination, business, Drugs, Chinese Herbal
Abstract

Objective To investigating the molecular mechanism of herbal pairs in three types of Chinese medicinals: Qi-tonifying, blood activation, blood-stasis breaking in treatment of coronary heart disease (CHD). Methods The components of six herbs were searched in Chinese medicine dictionary and their target proteins were found in PubChem. CHD genes were obtained from PubMed gene database. Ingenuity Pathways Analysis was used to build the pharmacological network of three herbal pairs and CHD molecular network. The canonical pathways between each herbal pair network and CHD network was compared to decipher the molecular mechanism on three herbal pairs in treating CHD. Results The network analysis showed that there were the common signal pathways of three herbal pairs in treating CHD including hypoxia signaling in the cardiovascular system, Hypoxia-inducible factor 1-alpha signaling, glucocorticoid receptor signaling, G-Protein coupled receptor signaling and pregnane X receptor/retinoid X receptor (PXR/RXR) activation. Further to analyze cardiovascular signaling, cytokine signaling and cytokine signaling, the effective molecules for three herbal pairs in treating CHD included HIF1α and estrogen receptor 1, Qi-tonifying herbal pair included albumin and matrix metallopeptidase 2, and blood-activation herbal pair included estrogen receptor 2 and peroxisome proliferator-activated receptor-γ. Conclusion Each herbal pair can affect some respective CHD-related functions and pathways, meanwhile three herbal pairs exert some mutual effects on CHD-related functions and pathways. Mutual effects of three herbal pairs may be the key components of their total molecular mechanisms and respective effects of each herbal pair may be the characteristic components of their respective molecular mechanism.

Published
2017

5. Differential Amino Acid, Carbohydrate and Lipid Metabolism Perpetuations Involved in a Subtype of Rheumatoid Arthritis with Chinese Medicine Cold Pattern

Author

Guo, Hongtao, primary, Niu, Xuyan, additional, Gu, Yan, additional, Lu, Cheng, additional, Xiao, Cheng, additional, Yue, Kevin, additional, Zhang, Ge, additional, Pan, Xiaohua, additional, Jiang, Miao, additional, Tan, Yong, additional, Kong, Hongwei, additional, Liu, Zhenli, additional, Xu, Guowang, additional, and Lu, Aiping, additional

Published
2016
Full Text
View/download PDF

8. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery

Author

Li, Jian, Lu, Cheng, Jiang, Miao, Niu, Xuyan, Guo, Hongtao, Li, Li, Bian, Zhaoxiang, Lin, Na, and Lu, Aiping

Subjects
Article Subject
Abstract

Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery. Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases. Interestingly, traditional chinese medicine (TCM) has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification. Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed. In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery. A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks. Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug.

Published
2012
Full Text
View/download PDF

10. Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial

Author

Jiang, Miao, primary, Zha, Qinglin, additional, Zhang, Chi, additional, Lu, Cheng, additional, Yan, Xiaoping, additional, Zhu, Wanhua, additional, Liu, Wei, additional, Tu, Shenghao, additional, Hou, Liping, additional, Wang, Chengwu, additional, Zhang, Wandong, additional, Liang, Qinghua, additional, Fan, Bing, additional, Yu, Jiangping, additional, Zhang, Weidong, additional, Liu, Xinru, additional, Yang, Jing, additional, He, Xiaojuan, additional, Li, Li, additional, Niu, Xuyan, additional, Liu, Yan, additional, Guo, Hongtao, additional, He, Bing, additional, Zhang, Ge, additional, Bian, Zhaoxiang, additional, and Lu, Aiping, additional

Published
2015
Full Text
View/download PDF

11. Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers

Author

Kwan, Hiu Yee, primary, Niu, Xuyan, additional, Dai, Wenlin, additional, Tong, Tiejun, additional, Chao, Xiaojuan, additional, Su, Tao, additional, Chan, Chi Leung, additional, Lee, Kim Chung, additional, Fu, Xiuqiong, additional, Yi, Hua, additional, Yu, Hua, additional, Li, Ting, additional, Tse, Anfernee Kai Wing, additional, Fong, Wang Fun, additional, Pan, Si-Yuan, additional, Lu, Aiping, additional, and Yu, Zhi-Ling, additional

Published
2015
Full Text
View/download PDF

14. Serum metabolomics reveals betaine and phosphatidylcholine as potential biomarkers for the toxic responses of processed Aconitum carmichaelii Debx

Author

Tan, Yong, primary, Ko, Joshua, additional, Liu, Xinru, additional, Lu, Cheng, additional, Li, Jian, additional, Xiao, Cheng, additional, Li, Li, additional, Niu, Xuyan, additional, Jiang, Miao, additional, He, Xiaojuan, additional, Zhao, Hongyan, additional, Zhang, Zhongxiao, additional, Bian, Zhaoxiang, additional, Yang, Zhijun, additional, Zhang, Ge, additional, Zhang, Weidong, additional, and Lu, Aiping, additional

Published
2014
Full Text
View/download PDF

15. Serum Metabolic Signatures of Four Types of Human Arthritis

Author

Jiang, Miao, primary, Chen, Tianlu, additional, Feng, Hui, additional, Zhang, Yinan, additional, Li, Li, additional, Zhao, Aihua, additional, Niu, Xuyan, additional, Liang, Fei, additional, Wang, Minzhi, additional, Zhan, Junping, additional, Lu, Cheng, additional, He, Xiaojuan, additional, Xiao, Lianbo, additional, Jia, Wei, additional, and Lu, Aiping, additional

Published
2013
Full Text
View/download PDF

18. Deciphering the Differential Toxic Responses of Radix aconiti lateralis praeparata in Healthy and Hydrocortisone-Pretreated Rats Based on Serum Metabolic Profiles

Author

Tan, Yong, primary, Li, Jian, additional, Liu, Xinru, additional, Ko, Joshua, additional, He, Xiaojuan, additional, Lu, Cheng, additional, Liu, Zhenli, additional, Zhao, Hongyan, additional, Xiao, Cheng, additional, Niu, Xuyan, additional, Zha, Qingling, additional, Yu, Zhiling, additional, Zhang, Weidong, additional, and Lu, Aiping, additional

Published
2012
Full Text
View/download PDF

27. Deciphering the differential toxic responses of Radix aconiti lateralis praeparata in healthy and hydrocortisone-pretreated rats based on serum metabolic profiles.

Author

Tan Y, Li J, Liu X, Ko J, He X, Lu C, Liu Z, Zhao H, Xiao C, Niu X, Zha Q, Yu Z, Zhang W, and Lu A

Subjects
Aconitum chemistry, Animals, Drugs, Chinese Herbal pharmacology, Humans, Hydrocortisone administration & dosage, Kidney drug effects, Kidney metabolism, Liver drug effects, Liver metabolism, Mass Spectrometry, Rats, Yang Deficiency blood, Yang Deficiency metabolism, Drug-Related Side Effects and Adverse Reactions drug therapy, Drug-Related Side Effects and Adverse Reactions pathology, Drugs, Chinese Herbal adverse effects, Medicine, Chinese Traditional, Metabolome genetics
Abstract

Radix aconiti lateralis praeparata (Baifupian) has received great attention because of its excellent therapeutic effects as well as the associated adverse drug reactions. According to the traditional Chinese medicine (TCM) principle, Baifupian should only be used in patients with TCM "kidney-yang" deficiency pattern, a clinical state that can be mimicked by hydrocortisone induction in rats. This study aimed to decipher the differential toxic responses of Baifupian in healthy and hydrocortisone-pretreated rats based on serum metabolic profiles. Drug-treated rats received Baifupian intragastrically at the dose of 1.28 g/kg/day for 15 days. Serum metabolic profiles were obtained by using the LC-Q-TOF-MS technique. Our results show that Baifupian could induce severe toxicity in the heart, liver, and kidneys of healthy rats. These drug-induced toxic reactions were largely alleviated in hydrocortisone-pretreated animals. Changes of metabolic profiles in drug-treated healthy and hydrocortisone-pretreated rats were demonstrated, involving oxidative phosphorylation, amino acid and lipid metabolism as characterized by altered phosphate, betaine, and phosphatidyl choline. These metabolic alterations could be responsible at least in part for the differential toxic responses of Baifupian under various health conditions. This study provides a new paradigm for better understanding of the risks and limitations when using potentially toxic herbs in clinical applications.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results