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Your search keyword '"Niu, Xingjian"' showing total 32 results
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32 results on '"Niu, Xingjian"'

2. Preliminary safety and efficacy of TQB2930, a HER2-targeted bispecific antibody in patients with advanced breast cancer: Results from a phase 1b study.

Author

Zhang, Qingyuan, primary, Wang, Jingxuan, additional, Li, Liru, additional, Zeng, Xiaohua, additional, Zhang, Han, additional, Song, Ying, additional, Tang, Dabei, additional, Niu, Xingjian, additional, Ma, Wenjie, additional, Tu, Lifan, additional, Fu, Shuang, additional, and Pan, Zoucheng, additional

Published
2024
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3. Effect of taurine intervention on oleic acid-induced primary hepatocyte steatosis in orange-spotted grouper (Epinephelus coioides)

Author

Xiao Ruyi, Feng Hanmo, Niu Xingjian, Bai Fakai, and Ye Jidan

Subjects
epinephelus coioides, taurine, hepatocyte steatosis, differential expression gene, rna-seq, Biology (General), QH301-705.5
Abstract

Examination of the molecular mechanism of taurine regulation of lipid metabolism in fish is limited. In this study, an oleic acid (OA)-induced hepatocyte steatosis model of orange-spotted grouper (Epinephelus coioides) was established for the first time. The model was used to test the effect of taurine on steatosis hepatocytes in Control, High-fat (0.4 mM OA) and Taurine (0.4 mM OA + 2 mM taurine) experimental groups of fish. Hepatocyte samples were subjected to transcriptome analysis. A total of 99634 unigenes was assembled, 69982 unigenes were annotated and 1831 differentially expressed genes (DEGs) in Control vs High-fat group, and 526 DEGs in the High-fat vs Taurine group were identified, of which 824 DEGs (Control vs High-fat) and 237 DEGs (High-fat vs Taurine) were observed to be upregulated, and 1007 DEGs (Control vs High-fat) and 289 DEGs (High-fat vs Taurine) were downregulated after taurine intervention. These genes are involved in peroxisome proliferator-activated receptor (PPAR) and 5’ AMP-activated protein kinase (AMPK) signaling pathways, fatty acid elongation, primary bile acid biosynthesis, glycerophospholipid and glycerolipid metabolism. The findings provide new clues in understanding the regulatory role of taurine in lipid and fatty acid metabolism of fish. It is hoped that the obtained results will help in the design of feed formulations to improve grouper growth from the perspective of aquaculture nutrition.

Published
2021
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8. Characteristics and survival analysis of breast cancer survivors with metachronous double primary cancers: a retrospective cohort study

Author

Song, Ying, primary, Wang, Jinlu, additional, Wang, Xiuli, additional, Li, Rui, additional, Niu, Xingjian, additional, Yang, Yue, additional, Yang, Xudong, additional, Yin, Lei, additional, Wang, Yiran, additional, Zhang, Han, additional, Shui, Ruixue, additional, Zhang, Cuiying, additional, and An, Jing, additional

Published
2023
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10. Characteristics and survival analysis of breast cancer survivors with metachronous double primary cancers: a retrospective cohort study

Author

Ma, Jianli, primary, Wang, Jinlu, additional, Wang, Xiuli, additional, Li, Rui, additional, Niu, Xingjian, additional, Yang, Yue, additional, Yang, Xudong, additional, Yin, Lei, additional, Wang, Yiran, additional, Zhang, Han, additional, Shui, Ruixue, additional, Zhang, Cuiying, additional, and Song, Ying, additional

Published
2023
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12. Analyzing the multi-target pharmacological mechanism of folium Artemisia argyi acting on breast cancer: a network pharmacology approach

Author

Song, Ying, primary, Wang, Jinlu, additional, Wang, Xiuli, additional, Zhang, Han, additional, Niu, Xingjian, additional, Yang, Yue, additional, Yang, Xudong, additional, Yin, Lei, additional, Wang, Yiran, additional, Zhang, Cuiying, additional, Shui, Ruixue, additional, Zhang, Qingyuan, additional, and Ji, Hongfei, additional

Published
2022
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14. The Lipid-Lowering Effect of Dietary Taurine in Orange-Spotted Groupers (Epinephelus coioides) Involves Both Bile Acids and Lipid Metabolism

Author

Wang, Xuexi, Bai, Fakai, Niu, Xingjian, Sun, Yunzhang, and Ye, Jidan

Subjects
Global and Planetary Change, Ocean Engineering, Aquatic Science, Oceanography, Water Science and Technology
Abstract

An 8-week feeding trial was conducted to investigate how dietary taurine supplementation attenuates the lipid deposition induced by dietary high lipid in juvenile orange-spotted grouper (Epinephelus coioides). Three isonitrogenous (47% crude protein) semipurified diets were formulated to contain two levels of lipid and termed as 10% lipid diet, 15% lipid diet, and 15% lipid with 1% taurine (namely, diet 10L, diet 15L, and diet 15L + T, respectively). Groupers fed diet 15L + T showed higher weight gain and feed efficiency compared with diet 15L. Groupers fed diet 15L showed higher liver lipid contents, plasma total cholesterol (TC), and leptin contents vs. those fed diet 10L. Diet 15L + T decreased hepatosomatic index, liver lipid content, and plasma TC and adiponectin contents, and increased liver 3-hydroxy-3-methy1 glutary1 coenzyme A reductase content compared with diet 15L. Fish fed diet 15L had higher contents of chenodeoxycholic acid, deoxycholic acid, and lithocholic acid, and lower contents of glycodeoxycholic acid (GDCA), glycolithocholic acid, glycoursodeoxycholic acid, taurodeoxycholic acid (TDCA), and β-, γ-, and ω-muricholic acid (MCA) when compared with fish fed diet 10L. Diet 15L + T downregulated the contents of glycocholic acid, glycochenodeoxycholic acid, taurohyodeoxycholic acid, tauromuricholic acid, TDCA, ursodeoxycholic acid, GDCA, and β-MCA vs. diet 15L. Diet 15L upregulated expression of peroxisome proliferator-activated receptor α (pparα) gene but downregulated expression of acyl-CoA carboxylase (acc), fatty acid synthase (fas), and glucose-6-phosphate dehydrogenase (g6pd) genes in comparison with diet 10L. The gene expression level of fas and 6pgd was downregulated and the pparα gene expression level was upregulated in fish fed diet 15L + T compared with those in fish fed diet 15L. Overall, this study indicated that dietary taurine supplementation can attenuate the liver lipid deposition of groupers caused by feeding 15% lipid through accelerating lipid absorption of taurine-conjugated bile acids and fatty acid β-oxidation and inhibiting lipogenesis.

Published
2022

18. High dose and hepatobiliary dysfunction are associated with hand-foot syndrome in patients with lymphoma using pegylated liposomal doxorubicin : a retrospective study

Author

Zhao, Yanfang, primary, Su, Wenjia, additional, Zhang, Qingyuan, additional, Liang, Guohua Liang, additional, Shan, Xiaoyu, additional, Ma, Weiwei, additional, Tang, Dabei, additional, Li, Liru, additional, Niu, Xingjian, additional, Zhao, Shu, additional, and zhao, Wenhui, additional

Published
2021
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23. Sodium-Dependent Glucose Transporter 1 (SGLT1) Stabled by HER2 Promotes Breast Cancer Cell Proliferation by Activation of the PI3K/Akt/mTOR Signaling Pathway in HER2+ Breast Cancer

Author

Wang, Jinlu, primary, Ji, Hongfei, additional, Niu, Xingjian, additional, Yin, Lei, additional, Wang, Yiran, additional, Gu, Yucui, additional, Li, Dongbo, additional, Zhang, Han, additional, Lu, Minghui, additional, Zhang, Fengxia, additional, and Zhang, Qingyuan, additional

Published
2020
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26. High Expression of Plakoglobin Promotes Metastasis in Invasive Micropapillary Carcinoma of the Breast via Tumor Cluster Formation

Author

Huang, Lan, primary, Ji, Hongfei, additional, Yin, Lei, additional, Niu, Xingjian, additional, Wang, Yiran, additional, Liu, Yang, additional, Xuan, Qijia, additional, Li, Liru, additional, Zhang, Han, additional, Zhou, Xiaoping, additional, Li, Jingtong, additional, Cui, Chengwei, additional, Yang, Yue, additional, An, Weiwei, additional, and Zhang, Qingyuan, additional

Published
2019
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27. Tumor‐associated macrophages secrete CC‐chemokine ligand 2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancer.

Author

Li, Dongbo, Ji, Hongfei, Niu, Xingjian, Yin, Lei, Wang, Yiran, Gu, Yucui, Wang, Jinlu, Zhou, Xiaoping, Zhang, Han, and Zhang, Qingyuan

Abstract

Breast cancer is the most prevalent malignancy among women. Although endocrine therapy is effective, the development of endocrine resistance is a major clinical challenge. The tumor microenvironment (TME) promotes tumor malignancy, and tumor‐associated macrophages (TAM) within the TME play a crucial role in endocrine resistance. Herein, we aimed to elucidate the relationship between TAM and the endocrine‐resistant phenotype of breast cancer. Macrophages were cultured with conditioned medium (CM) from tamoxifen‐sensitive (MCF7‐S) or ‐resistant (MCF7‐R) MCF7 breast cancer cells. M2 polarization was detected by CD163 immunofluorescence. To determine the effect on endocrine resistance, MCF7 cells were cultured in the supernatant of different TAM, and then treated with tamoxifen. CC‐chemokine ligand 2 (CCL2) immunohistochemistry was carried out on pathological sections from 100 patients with invasive estrogen receptor‐positive breast cancer. We found that macrophages cultured in the CM of MCF7‐S and MCF7‐R cells were induced into TAM, with a more obvious M2 polarization in the latter. Tamoxifen resistance was increased by culture in TAM medium. TAM secreted CCL2, which increased endocrine resistance in breast cancer cells through activation of the PI3K/Akt/mTOR signaling pathway. High expression of CCL2 was correlated with infiltration of CD163+macrophages (r = 0.548, P <.001), and patients with high CCL2 expression presented shorter progression‐free survival than those with low CCL2 expression (P <.05). We conclude that CCL2 secreted by TAM activates PI3K/Akt/mTOR signaling and promotes an endocrine resistance feedback loop in the TME, suggesting that CCL2 and TAM may be novel therapeutic targets for patients with endocrine‐resistant breast cancer. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Systemic immune response associated with radiation therapy in B‑cell non‑Hodgkin's lymphoma of Waldeyer's ring

Author

Niu, Xingjian, primary, Ji, Hongfei, additional, Wang, Yiran, additional, Hu, Songliu, additional, Xuan, Qijia, additional, Huang, Lan, additional, Yin, Lei, additional, Su, Wenjia, additional, Li, Liru, additional, Zhang, Han, additional, Li, Jingtong, additional, Yang, Yue, additional, An, Weiwei, additional, and Zhang, Qingyuan, additional

Published
2018
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30. Correction: Corrigendum: Photothermal therapeutic application of gold nanorods-porphyrin-trastuzumab complexes in HER2-positive breast cancer

Author

Kang, Xinmei, primary, Guo, Ximing, additional, Niu, Xingjian, additional, An, Weiwei, additional, Li, Suhan, additional, Liu, Zhaoliang, additional, Yang, Yue, additional, Wang, Na, additional, Jiang, Qicheng, additional, Yan, Caichuan, additional, Wang, Hui, additional, and Zhang, Qingyuan, additional

Published
2017
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